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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000260197':
SORL1 - Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell (Probable). Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans- Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the e [...]
[a.k.a. 3WSY, E9PKB0, ENST00000260197.11]
2) '9606.ENSP00000407552':
GAS7 - Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons.
[a.k.a. AC005747.1, AC107938, ENST00000579140.5]
3) '9606.ENSP00000329880':
PHACTR1 - Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (By similarity).
[a.k.a. CH471087, NP_001309238, ENSP00000368631]
4) '9606.ENSP00000351059':
CX3CR1 - CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV- 1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
[a.k.a. R-HSA-388396, uc021wwb.2, NM_001171171.1]
5) '9606.ENSP00000291700':
S100B - Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...]
[a.k.a. NEF, CH471079, 6285]
6) '9606.ENSP00000312185':
ELMO1 - Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
[a.k.a. 2VSZ, ELMO1-208, XP_011513956]
7) '9606.ENSP00000258526':
PLXNC1 - Plexin-C1; Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity). Belongs to the plexin family.
[a.k.a. 3NVN, XM_017018671.2, Plexin C]
8) '9606.ENSP00000427114':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000400892':
TESPA1 - Protein TESPA1; Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.
[a.k.a. EAW96800.1, NP_001129502.1, EAW96802.1]
10) '9606.ENSP00000465261':
TMC6 - Transmembrane channel-like protein 6; Probable ion channel; Belongs to the TMC family.
[a.k.a. ENST00000591756, NM_001127198.2, ENSP00000468255]
11) '9606.ENSP00000356155':
PIK3C2B - Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades; Belongs to the PI3/PI4-kinase family.
[a.k.a. ENST00000367184, NP_002637, XR_241085]
12) '9606.ENSP00000283148':
UXS1 - UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
[a.k.a. ENST00000283148, 80146, EC 4.1.1.35]
13) '9606.ENSP00000443926':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
14) '9606.ENSP00000284073':
MSI2 - RNA-binding protein Musashi homolog 2; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity); Belongs to the Musashi family.
[a.k.a. XM_017024148.1, ENST00000579180, XM_005257015]
15) '9606.ENSP00000452746':
PSTPIP1 - Proline-serine-threonine phosphatase-interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T- cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). [...]
[a.k.a. XM_011522166.2, XM_011522165, NP_003969]
16) '9606.ENSP00000416523':
SEMA4D - Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induce [...]
[a.k.a. SEMA4D-205, ENST00000450295, SEMA4D-204]
17) '9606.ENSP00000305355':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
18) '9606.ENSP00000302935':
IL16 - Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintai [...]
[a.k.a. IL16-207, ENST00000559953, IL-16]
19) '9606.ENSP00000371535':
SEPSECS - O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family.
[a.k.a. O-phosphoseryl-tRNA(Sec) selenium transferase, UPI0001D3B1F7, CAB62209.1]
20) '9606.ENSP00000349770':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
101 query items
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