searching ... STRING: functional protein association networks

ARHGEF33 - Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor. [a.k.a. R-HSA-388396, ARHGEF33-206, ARHGEF33-205]

SCARB1 - Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. [a.k.a. Q52LZ5, UPI000189A7D4, NP_001076428.1]

SCARB2 - Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. [a.k.a. 4TVZ, ENST00000452464, Lysosome membrane protein 2]

GOLGA6L4 - Golgin subfamily A member 6-like protein 4; Golgin A6 family like 4; Belongs to the GOLGA6 family. [a.k.a. ENSP00000421586, NM_001267536, OTTHUMG00000163050]

SLC36A1 - Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid (By similarity). [a.k.a. XP_006714822.1, R-HSA-352230, XM_011537587]

ANAPC4 - Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. [a.k.a. R-HSA-2555396, R-HSA-174084, CAB89245.1]

DNAJB13 - DnaJ homolog subfamily B member 13; Plays a role in the formation of the central complex of ciliary and flagellar axonemes. [a.k.a. 374407, NX_P59910, Q8IZW5]

CD86 - T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [a.k.a. R-HSA-9006925, B70, NP_787058]

NCOA3 - Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via [...] [a.k.a. Q9Y6Q9, AAC51663.1, R-HSA-5619507]

GOLGA6L9 - Golgin subfamily A member 6-like protein 9; Golgin A6 family like 9. [a.k.a. AAH41854.1, ENST00000354519, GOLGA6L9-201]

RBMX - RNA-binding motif protein, X chromosome, N-terminally processed; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the suprasplic [...] [a.k.a. Z23064, NM_001164803.2, R-HSA-72203]

DPYS - Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate. [a.k.a. 1807, UPI000012986F, ENST00000521601]

TCP1 - T-complex protein 1 subunit alpha; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). [a.k.a. NP_110379, ENSP00000317334, TCPA_HUMAN]

ZNF678 - Zinc finger protein 678; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. [a.k.a. ENSP00000332575, MGC42493, ENSG00000181450]

SOAT1 - Sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. [a.k.a. CCDS58047, ENSG00000057252, STAT]

N4BP2 - NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination. [a.k.a. NP_060647.2, Q86UW6, XM_011513716.2]

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