searching ... STRING: functional protein association networks

TMPO - Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1. [a.k.a. R-HSA-2555396, U09087, ENSP00000376773]

SGO1 - Shugoshin 1; Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congressi [...] [a.k.a. AB193065, NP_001186182.1, R-HSA-2555396]

COLEC11 - Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] [a.k.a. NM_001255987.1, Q9BWP8, NM_001255986.1]

FAM110A - Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family. [a.k.a. OMIM:611393, ENSG00000125898, ENSP00000354163]

CEACAM19 - CEA cell adhesion molecule 19; Belongs to the immunoglobulin superfamily. CEA family. [a.k.a. Carcinoembryonic antigen-like 1, NX_Q7Z692, ENSP00000466592]

DHRS4 - Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. [a.k.a. NM_001282988.2, XP_006720068, B2RB10]

HSPA12B - Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family. [a.k.a. ENST00000379790, 116835, Q2TAK3]

TMEM47 - Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity); Belongs to the TMEM47 family. [a.k.a. HGNC:18515, BCMP1, transmembrane 4 superfamily member 10]

DYRK2 - Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosp [...] [a.k.a. 2.7.12.1, AAH05809.1, CHEMBL4376]

DHRS4L2 - Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase. [a.k.a. ENST00000534993, NP_932349.2, Q6PKH6]

HOGA1 - 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline; Belongs to the DapA family. [a.k.a. AAH45550.1, DHDPSL, EC 4.1.3.16]

HERPUD1 - Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. [a.k.a. ENSP00000457955, ENST00000563911.5, Mif1]

RXFP4 - Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to the G-protein coupled receptor 1 family. [a.k.a. NM_181885.2, R-HSA-388396, GPR100]

PGAP1 - GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). [a.k.a. ENST00000409475, ENST00000459896, AAX88854.1]

GOPC - Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes. [a.k.a. ENSP00000445690, ENST00000535237, ENSP00000357484]

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