searching ... STRING: functional protein association networks

CXCL10 - C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increas [...] [a.k.a. R-HSA-388396, CAA26370.1, INP10]

GRP - Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity). [a.k.a. CCDS11971.1, R-HSA-388396, ENST00000456142]

C2CD4B - C2 calcium-dependent domain-containing protein 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family. [a.k.a. XM_017022170.1, hsa:388125, A6NLJ0]

H2AC1 - Histone H2A type 1-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [a.k.a. 5GSU, R-HSA-5689880, 5GT0]

HECA - Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs. [a.k.a. NP_057301, ENST00000230165, OMIM:607977]

OXT - Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. [a.k.a. R-HSA-388396, Oxytocin/neurophysin I prepropeptide, AAA59979.1]

BHMT - Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. [a.k.a. CCDS4046.1, AC008502, ENSG00000145692]

CXCL6 - Small-inducible cytokine B6, N-processed variant 1; Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). [a.k.a. R-HSA-388396, NM_002993.3, ENST00000226317.9]

CCL13 - C-C motif chemokine 13, medium chain; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens; Belongs to the intercrine beta (chemokine CC) family. [a.k.a. R-HSA-388396, CK-beta-10, R-HSA-162582]

PLGLB1 - Plasminogen-like protein B; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasminogen and may result in the localization of activity at sites necessary for extracellular matrix destruction. [a.k.a. ENST00000355705.3, Q02325, PRGB]

LSM4 - U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. [a.k.a. LSM4-201, NM_001252129, 6AH0]

UCMA - Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. [a.k.a. uc057rts.1, NP_001290048.1, BC018068]

GAL - Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family. [a.k.a. ENSP00000265643, R-HSA-388396, R-HSA-162582]

AQP3 - Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] [a.k.a. Q92482, NM_001318144.1, ENSP00000297991]

GATD3A - Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial; Glutamine amidotransferase like class 1 domain containing 3A; Belongs to the GATD3 family. [a.k.a. XM_024452133, ENST00000389689, ES1 protein homolog]

BPIFA1 - BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid ho [...] [a.k.a. NP_001230122.1, E1P5M9, NM_130852.2]

KRT17 - Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state (By similarity). Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity). Involved in tissue repair. May be a mark [...] [a.k.a. PCHC1, ENSP00000497796, Cytokeratin-17]

TMSB15A - Thymosin beta-15A; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. [a.k.a. Thymosin-like protein 8, 11013, Q99406]

GATD3B - Glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial; Glutamine amidotransferase like class 1 domain containing 3B; Belongs to the GATD3 family. [a.k.a. GATD3B-209, ENSP00000485058, XP_011507208.1]

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