searching ... STRING: functional protein association networks

Version:
12.0

The following proteins in Homo sapiens appear to match your input.
Please review the list, then click 'Continue' to proceed.

<- Back ⤓ Mapping Continue ->

103 query items

showing page 1 of 6 • first • previous • next • last

1) '9606.ENSP00000306245':

FOS - Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentia [...] [a.k.a. ENSP00000306245, ENST00000303562.8, BAG53458.1]

2) '9606.ENSP00000384748':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

3) '9606.ENSP00000416040':

KIAA1549 - UPF0606 protein KIAA1549; KIAA1549; Belongs to the UPF0606 family. [a.k.a. UPI0001837EBD, CAQ43114.1, ENSG00000122778]

4) '9606.ENSP00000343246':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

5) '9606.ENSP00000367830':

PRKCZ - Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] [a.k.a. R-HSA-170834, ENST00000497183, PRKCZ-203]

6) '9606.ENSP00000336831':

PLS1 - Plastin-1; Actin-bundling protein in the absence of calcium. [a.k.a. XP_016862115, XP_011511202.1, ENST00000483507.1]

7) '9606.ENSP00000385727':

MAST4 - Microtubule associated serine/threonine kinase family member 4; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. [a.k.a. XM_017009449, CCDS75254.1, AK131421]

8) '9606.ENSP00000381857':

MROH6 - Maestro heat like repeat family member 6. [a.k.a. Maestro heat like repeat family member 6, XM_011517214.1, XP_006716678.1]

9) '9606.ENSP00000441765':

PTHLH - Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...] [a.k.a. R-HSA-388396, PTHRP, R-HSA-162582]

10) '9606.ENSP00000308576':

RHOD - Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution; Belongs to the small GTPase superfamily. Rho family. [a.k.a. 29984, 2J1L, R-HSA-162582]

11) '9606.ENSP00000431284':

LPXN - Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. [a.k.a. HPA043741, ENST00000412226, ENSP00000431284]

12) '9606.ENSP00000288025':

TMED6 - Transmembrane p24 trafficking protein 6. [a.k.a. Q8WW62, TMED6-201, p24g5]

13) '9606.ENSP00000478212':

AKAP1 - A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. [a.k.a. ENSP00000478212, protein phosphatase 1, regulatory subunit 43, ENST00000575322.1]

14) '9606.ENSP00000366748':

AUP1 - Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family. [a.k.a. AK023983, ENST00000244190, CCDS42702.1]

15) '9606.ENSP00000385450':

MAGI1 - Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). [a.k.a. AIP-3, ENST00000402939, 9223]

16) '9606.ENSP00000368589':

GFOD1 - Glucose-fructose oxidoreductase domain containing 1; Belongs to the Gfo/Idh/MocA family. [a.k.a. CH471087, NM_001242630.1, Q9H5K2]

17) '9606.ENSP00000368173':

DHRS13 - Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase. [a.k.a. ENSP00000291979, ENST00000581974, ENST00000581759]

18) '9606.ENSP00000391800':

APLN - Apelin-13; Endogenous ligand for the apelin receptor (APLNR). Drives internalization of the apelin receptor (By similarity). Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR (By similarity). Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis (By similarity). Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates (By similarity). Plays a role in early co [...] [a.k.a. R-HSA-388396, CHEMBL3232687, Q9ULZ1]

19) '9606.ENSP00000400341':

FOXA2 - Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] [a.k.a. TCF3B, ENST00000419308, EAX10175.1]

20) '9606.ENSP00000462099':

RASSF5 - Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras [...] [a.k.a. AAH04270.1, Ras association domain-containing protein 5, Ras association domain family member 5]

103 query items

showing page 1 of 6 • first • previous • next • last

<- Back ⤓ Mapping Continue ->

© STRING Consortium 2023

Credits

Access

Info

About