searching ... STRING: functional protein association networks

RFNG - Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. [a.k.a. ENST00000320924, R-HSA-162582, ENST00000580793]

MFSD11 - UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family. [a.k.a. MFSD11-215, XP_011523546, ENST00000262770]

CNFN - Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the cornifelin family. [a.k.a. AAI01199.1, Q9BYD5, 84518]

TGOLN2 - Trans-Golgi network integral membrane protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network. [a.k.a. TTGN2, ENSP00000386443, AAC39542.1]

GPS1 - COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kina [...] [a.k.a. NP_997657.1, UPI000268B263, R-HSA-6781823]

F13A1 - Coagulation factor XIII A chain; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. [a.k.a. UPI0003F48403, Coagulation factor XIII A chain, F13A]

XBP1 - X-box-binding protein 1, cytoplasmic form; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity). Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regio [...] [a.k.a. BC012841, NM_001079539, XBP-1]

NUDT22 - Uridine diphosphate glucose pyrophosphatase NUDT22; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose; Belongs to the Nudix hydrolase family. [a.k.a. XM_024448714.1, MGC13045, NP_001122085.1]

H6PD - GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes (By similarity). Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconola [...] [a.k.a. 9563, CAH18137.1, GDH/6PGL endoplasmic bifunctional protein]

SLC16A4 - Monocarboxylate transporter 5; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). [a.k.a. E7EPY8, NP_001188476, XP_005271374.1]

DPYSL3 - Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). [a.k.a. OTTHUMG00000163437, CAA69153.1, R-HSA-399956]

CSAG1 - Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. [a.k.a. ENSP00000359310, ENSG00000198930, NP_001096046]

DHX9 - ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo- nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA [...] [a.k.a. 1660, ENSP00000356520, DEAH box protein 9]

SLC25A1 - Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation (Probable). [a.k.a. SLC20A3, ENST00000451283, OMIM:190315]

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