searching ... STRING: functional protein association networks

VARS1 - Valine--tRNA ligase; valyl-tRNA synthetase 1; Belongs to the class-I aminoacyl-tRNA synthetase family. [a.k.a. XM_024446537, R-HSA-379716, UPI0000E5AD1A]

CHTOP - Chromatin target of PRMT1 protein; Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP- methylosome complex associated with 5hmC is recruited to sel [...] [a.k.a. chromosome 1 open reading frame 77, D3DV55, AAH02733.1]

SZT2 - KICSTOR complex protein SZT2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by gluc [...] [a.k.a. ENST00000310739, XR_001737075, chromosome 1 open reading frame 84]

SAMD1 - Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall. [a.k.a. ENSP00000269724, SAMD1-202, HGNC:17958]

MESP1 - Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). [a.k.a. AL357533, ENST00000559894, MESP1-201]

MEX3D - RNA-binding protein MEX3D; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms. [a.k.a. 399664, RNF193, NP_976049.3]

RRNAD1 - Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family. [a.k.a. ENST00000481920, OTTHUMG00000041302, UPI0003F4810D]

KCNK3 - Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [a.k.a. AF006823, 3777, TASK1]

KCNF1 - Potassium voltage-gated channel subfamily F member 1; Putative voltage-gated potassium channel. [a.k.a. Voltage-gated potassium channel subunit Kv5.1, AAG43055.1, EAX00946.1]

KLHDC10 - Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5. [a.k.a. CCDS5815, uc003vpj.3, UPI0001B7924B]

ETF1 - Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. [a.k.a. ENST00000360541, 2LLX, D6RCB3]

ADRB1 - Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling. Involved in the regulation of sleep/wake behaviors ; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB1 sub-subfamily. [a.k.a. R-HSA-388396, NM_000684.3, J03019]

GPC1 - Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting th [...] [a.k.a. R-HSA-388396, R-HSA-196854, R-HSA-202733]

BCL7C - B-cell CLL/lymphoma 7 protein family member C; May play an anti-apoptotic role. [a.k.a. XM_017023887.2, uc002dzv.5, XP_016879374]

NAT8L - N-acetylaspartate synthetase; Plays a role in the regulation of lipogenesis by producing N- acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and its hydrolysis plays a significant part in the maintenance of intact white matter. Promotes dopamine uptake by regulating TNF-alpha expression. Attenuates methamphetamine-induced inhibition of dopamine uptake. [a.k.a. NAT8-LIKE, NM_178557.4, 339983]

NAB2 - NGFI-A-binding protein 2; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity); Belongs to the NAB family. [a.k.a. Q15742, ENSP00000341491, ENST00000300131]

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