searching ... STRING: functional protein association networks

ZNF530 - Zinc finger protein 530; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. [a.k.a. ENSP00000472024, NM_001321981, Q9P220]

HSPG2 - Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. The LG3 peptide has anti-angiogenic properties that require [...] [a.k.a. R-HSA-388396, R-HSA-196854, NM_001291860]

KRTAP5-8 - Keratin-associated protein 5-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family. [a.k.a. ENSP00000420723, KRTAP5.8, UHS keratin B]

HLA-DMB - HLA class II histocompatibility antigen, DM beta chain; Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. [a.k.a. AL935042, CAA60782.1, uc003ocl.2]

LETM2 - LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2. [a.k.a. XP_016868541, ENSP00000429269, XP_011542708.1]

GNB2 - Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [a.k.a. R-HSA-388396, ENSG00000172354, NM_005273]

RPL18A - Ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family. [a.k.a. R-HSA-72737, UPI0002A472A0, R-HSA-2408522]

PTPA - Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the var [...] [a.k.a. 5524, ENST00000358994.8, ENST00000414510]

TMEM161A - Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis. [a.k.a. ENST00000587925, NM_017814.2, TMEM161A-215]

MSLN - Megakaryocyte-potentiating factor; Membrane-anchored forms may play a role in cellular adhesion; Belongs to the mesothelin family. [a.k.a. BC009272, Mesothelin, mesothelin]

TRPM4 - Transient receptor potential cation channel subfamily M member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating [...] [a.k.a. UPI0002A47369, R-HSA-3295583, NM_001321283.1]

F12 - Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. [a.k.a. 6QF7, M31315, FA12_HUMAN]

ALDH4A1 - Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes. [a.k.a. EAW94859.1, NM_001319218.1, aldehyde dehydrogenase 4 family member A1]

LAMTOR4 - Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated; Belongs to the LAMTOR4 family. [a.k.a. R-HSA-9006925, ENSG00000188186, R-HSA-8943724]

IRF7 - Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependen [...] [a.k.a. IRF7-202, ENSP00000434607, IRF7-204]

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