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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000334373':
KPNA4 - Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...]
[a.k.a. Karyopherin subunit alpha 4, R-HSA-168254, IPOA3]
2) '9606.ENSP00000209875':
CBX5 - Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
[a.k.a. AAA72327.1, HP1 alpha homolog (Drosophila), R-HSA-2990846]
3) '9606.ENSP00000255039':
HAPLN2 - Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid (By similarity).
[a.k.a. ENST00000487988.5, 60484, HAPLN2-202]
4) '9606.ENSP00000256969':
SPX - Spexin-1; Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity).
[a.k.a. NP_085049, ENSP00000256969, NM_030572]
5) '9606.ENSP00000354878':
KIF21A - Kinesin-like protein KIF21A; Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity).
[a.k.a. Q7Z4S6, KIF21A-209, FEOM1]
6) '9606.ENSP00000340465':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
7) '9606.ENSP00000347852':
SORBS2 - Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder.
[a.k.a. AK293400, ENSP00000416464, SORBS2-260]
8) '9606.ENSP00000220616':
TG - Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (By similarity). Following TG re- internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (By similarity).
[a.k.a. ENSP00000430523, NM_003235, XM_017013795.1]
9) '9606.ENSP00000229314':
GOLT1B - Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex.
[a.k.a. NP_057156.1, GOLT1B-202, ENST00000545113.1]
10) '9606.ENSP00000485078':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
11) '9606.ENSP00000479964':
SLC4A1AP - Kanadaptin; Solute carrier family 4 member 1 adaptor protein.
[a.k.a. HLC3, 4H87, AAH98302.1]
12) '9606.ENSP00000402301':
LAPTM4B - Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTOR [...]
[a.k.a. ENST00000517924, AAL17908.2, NM_018407.6]
13) '9606.ENSP00000262032':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
14) '9606.ENSP00000367498':
LRRC47 - Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47.
[a.k.a. ENST00000462356, Q8N1G4, ENSP00000367498]
15) '9606.ENSP00000354665':
MT-ND6 - NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
[a.k.a. ND6, JX152961, AHE79418.1]
16) '9606.ENSP00000379438':
UMOD - Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability (Probable). May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia.
[a.k.a. UPI00025A2F47, ENST00000396142, UMOD-201]
17) '9606.ENSP00000370966':
CRYZL1 - Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
[a.k.a. uc061zsg.1, QOH-1, ENST00000480893]
18) '9606.ENSP00000379619':
WDR72 - WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane.
[a.k.a. ENSP00000453378, AC024061, 256764]
19) '9606.ENSP00000265431':
CALB1 - Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
[a.k.a. ENST00000523716, AAC62230.1, BC006478]
20) '9606.ENSP00000379709':
ARHGAP21 - Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.
[a.k.a. ENST00000486374, XR_001747163.2, NR_160025.1]
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