searching ... STRING: functional protein association networks

HKDC1 - Hexokinase HKDC1; Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases. Has low glucose phosphorylating activity compared to other hexokinases. Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role (By similarity). [a.k.a. BC021278, FLJ22761, AAI10506.2]

PTPRC - Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily. [a.k.a. ENST00000367364, ENST00000367364.5, M23478]

PNPLA6 - Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. [a.k.a. ENSP00000394348, UPI0007699E5F, R-HSA-1483255]

DPYSL3 - Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). [a.k.a. OTTHUMG00000163437, CAA69153.1, R-HSA-399956]

ACSS3 - Acyl-CoA synthetase short-chain family member 3, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Propionate is the preferred substrate. Can utilize acetate and butyrate with a much lower affinity (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family. [a.k.a. A0A0B4J1R2, Propionate--CoA ligase, R-HSA-556833]

ZNF500 - Zinc finger protein 500; May be involved in transcriptional regulation. [a.k.a. ENSP00000379930, NM_001303450.1, ENST00000588602.1]

ARMCX1 - Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1. [a.k.a. Armadillo repeat containing X-linked 1, Q9H2Q0, ENSG00000126947]

ANGPT1 - Angiopoietin-1; Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells [...] [a.k.a. AK300319, HPA018816, R-HSA-202733]

ZNF451 - E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated ac [...] [a.k.a. NM_015555, ZNF451-207, XM_011514460]

YIPF5 - Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi. [a.k.a. CAH18295.1, BC007829, NP_001020118]

GOLGA1 - Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking. [a.k.a. HPA050555, ENST00000605438, ENST00000605438.1]

CD46 - Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) Acts as a receptor for Adenovirus [...] [a.k.a. XM_011509564.1, Q5VWT1, ENSP00000356008]

SCRN1 - Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity). [a.k.a. NM_014766, SCRN1-206, ENSP00000242059]

CD86 - T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. [a.k.a. R-HSA-9006925, B70, NP_787058]

RNASE12 - Probable inactive ribonuclease-like protein 12; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family. [a.k.a. CCDS32037.1, Q5GAN4, ENST00000556526.1]

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