searching ... STRING: functional protein association networks

SCN1B - Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of multiple pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A. [a.k.a. 6J8H, 6324, hsa:6324]

JAM3 - Junctional adhesion molecule C; Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (By similarity). Plays a role in spermatogenesis where JA [...] [a.k.a. ENSP00000299106, NM_032801, AP000911]

ULK2 - Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1 [...] [a.k.a. ENST00000571137.1, XP_016880914, XM_017025428]

FAXC - Failed axon connections homolog; May play a role in axonal development. [a.k.a. Failed axon connections homolog, BAG53301.1, ENSG00000146267]

MAP3K11 - Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. [a.k.a. ENST00000532507, E9PID4, R-HSA-162582]

GAS6 - Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. [a.k.a. R-HSA-202733, AXL receptor tyrosine kinase ligand, ENST00000327773.6]

POLL - DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. Belongs to the DNA polymerase type-X family. [a.k.a. NM_001174085.1, XM_011539667, DNA polymerase lambda]

TUBB3 - Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord. [a.k.a. R-HSA-2555396, ENST00000557262.5, ENSP00000451760]

PIDD1 - P53-induced death domain-containing protein 1; Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B. [a.k.a. XP_005253064.1, XP_011518515, ENSP00000322213]

ARHGEF10L - Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. [a.k.a. R-HSA-388396, ENSP00000326952, HPA026426]

CDC42BPA - Serine/threonine-protein kinase MRCK alpha; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. In concert with FAM89B/LRAP25 mediates the targeting [...] [a.k.a. ENST00000366764, OMIM:603412, ENST00000478573]

IDI1 - Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). [a.k.a. AAK29357.1, ENSP00000370748, NP_004499.2]

ASMTL - Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo- UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methy [...] [a.k.a. XP_005274840, uc004cpx.3, NM_001173473.1]

CEND1 - Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation. [a.k.a. BC034732, Q8N111, NM_016564]

IDI2 - Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). [a.k.a. Isopentenyl-diphosphate delta isomerase 2, ENST00000277517.1, ENSG00000148377]

MYO1B - Unconventional myosin-Ib; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. [a.k.a. CCDS2311, NM_001161819.3, ENSP00000376130]

PPP1R14B - Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity). [a.k.a. NX_Q96C90, 26472, ENSP00000310117]

FSD1 - Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization. [a.k.a. ENST00000598010, NM_024333, ENST00000221856]

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