searching ... STRING: functional protein association networks

SCARB1 - Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Belongs to the CD36 family. [a.k.a. Q52LZ5, UPI000189A7D4, NP_001076428.1]

SCARB2 - Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. [a.k.a. 4TVZ, ENST00000452464, Lysosome membrane protein 2]

NAV3 - Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family. [a.k.a. XP_016875654, AAM73757.1, OMIM:611629]

CCDC91 - Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes. [a.k.a. p56, ENSP00000440513, ENST00000541792.1]

RANGAP1 - Ran GTPase-activating protein 1; GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export. [a.k.a. R-HSA-162587, R-HSA-2555396, RANGAP1-207]

COL4A2 - Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. [a.k.a. ENST00000480771.5, COL4A2-201, ENSP00000353654]

ARAP2 - Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity). [a.k.a. ENST00000511416.1, CENTD1, centaurin, delta 1]

SMC6 - Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Req [...] [a.k.a. UPI000173A405, XM_011533107.3, structural maintenance of chromosomes 6]

SEZ6L2 - Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family. [a.k.a. SEZ6L2-202, NP_963869.2, Seizure related 6 homolog like 2]

PRKD3 - Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). [a.k.a. ENSG00000115825, ENSP00000368356, ENST00000469275.5]

PCDH1 - Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion. [a.k.a. ENST00000536585, ENST00000357517, ENST00000505937]

CPLX4 - Complexin-4; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). [...] [a.k.a. OTTHUMG00000132756, BC106887, AC067859]

APOO - MICOS complex subunit MIC26; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function. Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride trans [...] [a.k.a. BAG34806.1, UPI00002124C8, BC010102]

IL36A - Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and ce [...] [a.k.a. IL-1 epsilon, R-HSA-446652, XP_016859295]

FAM104A - Protein FAM104A; Family with sequence similarity 104 member A; Belongs to the FAM104 family. [a.k.a. ENSP00000462840, URS00008C2ADC, ENSP00000324317]

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