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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000363318':
IL2RG - Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Belongs to the type I cytokine receptor family. Type 5 subfamily.
[a.k.a. R-HSA-912526, L12179, ENST00000512747]
2) '9606.ENSP00000254323':
ZSWIM4 - Zinc finger SWIM-type containing 4.
[a.k.a. NM_001367834.2, ENSG00000132003, ENST00000254323.6]
3) '9606.ENSP00000386921':
TBC1D14 - TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
[a.k.a. AL833868, 57533, ENSP00000386921]
4) '9606.ENSP00000349252':
ITGAL - Integrin alpha-L; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R. Integin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutroph [...]
[a.k.a. M87662, R-HSA-202733, 6CKB]
5) '9606.ENSP00000416523':
SEMA4D - Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induce [...]
[a.k.a. SEMA4D-205, ENST00000450295, SEMA4D-204]
6) '9606.ENSP00000356224':
SYNE1 - Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment and nuclear migrati [...]
[a.k.a. ENSP00000318372, Q5JV19, Nesprin-1]
7) '9606.ENSP00000254667':
PTPRE - Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+); Belongs to the protein-tyrosine phosphatase family. Receptor class [...]
[a.k.a. ENST00000254667, NP_001310286.1, NP_006495.1]
8) '9606.ENSP00000399700':
PLAC8 - Placenta-specific gene 8 protein; Placenta associated 8.
[a.k.a. URS00008B6ED3, HGNC:19254, ENST00000505406.5]
9) '9606.ENSP00000228463':
SELPLG - P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
[a.k.a. Selectin P ligand, R-HSA-202733, NM_003006]
10) '9606.ENSP00000482604':
HSH2D - Hematopoietic SH2 domain-containing protein; May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.
[a.k.a. ENST00000591154, ENST00000355348, ENSP00000482604]
11) '9606.ENSP00000255945':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
12) '9606.ENSP00000262158':
SMAD7 - Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a [...]
[a.k.a. R-HSA-170834, ENST00000591805.5, CRCS3]
13) '9606.ENSP00000324890':
CD28 - T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
[a.k.a. CD28 molecule, ENST00000324167, R-HSA-9006925]
14) '9606.ENSP00000347847':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
15) '9606.ENSP00000265073':
SUB1 - Activated RNA polymerase II transcriptional coactivator p15; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
[a.k.a. SUB1 regulator of transcription, UPI0003F481DD, ENST00000506237]
16) '9606.ENSP00000296859':
RAPGEF6 - Rap guanine nucleotide exchange factor 6; Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
[a.k.a. Rap guanine nucleotide exchange factor 6, RA-GEF-2, A3KN82]
17) '9606.ENSP00000363040':
MEGF9 - Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9.
[a.k.a. AY358370, OMIM:604268, MEGF9_HUMAN]
18) '9606.ENSP00000336524':
CEP63 - Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to [...]
[a.k.a. ENSP00000427526, R-HSA-69278, NP_001340040]
19) '9606.ENSP00000252445':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
20) '9606.ENSP00000355991':
TRAF3IP3 - TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation.
[a.k.a. ENSP00000010338, ENSP00000355991, uc001hho.5]
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