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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000363318':
IL2RG - Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Belongs to the type I cytokine receptor family. Type 5 subfamily.
[a.k.a. R-HSA-912526, L12179, ENST00000512747]
2) '9606.ENSP00000380948':
ITGB2 - Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor [...]
[a.k.a. R-HSA-202733, ENST00000302347, E5RHE6]
3) '9606.ENSP00000386921':
TBC1D14 - TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy.
[a.k.a. AL833868, 57533, ENSP00000386921]
4) '9606.ENSP00000290341':
IGF2BP1 - Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Plays a direct role in the transport and translation of transcripts required for axonal regeneration in adult sensory neurons (By similarity). Regulates localized beta- actin/AC [...]
[a.k.a. XP_011522503.1, ABB46294.1, XM_005256955.3]
5) '9606.ENSP00000333657':
MX2 - Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression.
[a.k.a. 4600, ENST00000495892.1, MX2-204]
6) '9606.ENSP00000264972':
ZAP70 - Tyrosine-protein kinase ZAP-70; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B- lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated [...]
[a.k.a. ENST00000389516, 1M61, ENSP00000411141]
7) '9606.ENSP00000416523':
SEMA4D - Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induce [...]
[a.k.a. SEMA4D-205, ENST00000450295, SEMA4D-204]
8) '9606.ENSP00000258381':
SP110 - Sp110 nuclear body protein; Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
[a.k.a. XP_011509390, URS00008BD887, XM_017003968.2]
9) '9606.ENSP00000331614':
IKZF1 - DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus i [...]
[a.k.a. AC124014, CCDS59055.1, ENSP00000342378]
10) '9606.ENSP00000228463':
SELPLG - P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
[a.k.a. Selectin P ligand, R-HSA-202733, NM_003006]
11) '9606.ENSP00000458866':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
12) '9606.ENSP00000361345':
FAM78A - Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family.
[a.k.a. ENST00000372269, XM_011518567, CCDS6941]
13) '9606.ENSP00000354597':
DENND4B - DENN domain-containing protein 4B; Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab proteins into their active GTP-bound form.
[a.k.a. NM_014856, KIAA0476, DENND4B-202]
14) '9606.ENSP00000343273':
KLHL7 - Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
[a.k.a. UPI0000037B12, XP_006715817, XM_006715754]
15) '9606.ENSP00000386787':
TMEM131L - Transmembrane protein 131-like; [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
[a.k.a. ENST00000478919.1, ENST00000445960, NM_001131007]
16) '9606.ENSP00000255945':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
17) '9606.ENSP00000324890':
CD28 - T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.
[a.k.a. CD28 molecule, ENST00000324167, R-HSA-9006925]
18) '9606.ENSP00000325589':
PTPRCAP - Protein tyrosine phosphatase receptor type C associated protein.
[a.k.a. HPA043734, CR457429, 5790]
19) '9606.ENSP00000347847':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
20) '9606.ENSP00000309116':
PTPN7 - Tyrosine-protein phosphatase non-receptor type 7; Protein phosphatase that acts preferentially on tyrosine- phosphorylated MAPK1. Plays a role in the regulation of T and B- lymphocyte development and signal transduction. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.
[a.k.a. Q5SXQ1, 3D42, OMIM:176889]
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