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The following proteins in
Homo sapiens
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101 query items
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1) '9606.ENSP00000363436':
GPRIN2 - G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth.
[a.k.a. GPRIN2-202, ENST00000374317, XM_005277666.3]
2) '9606.ENSP00000377823':
NDRG4 - Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress (By similarity). May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner.
[a.k.a. BAB20068.1, ENST00000563022, H7C600]
3) '9606.ENSP00000362748':
TET1 - Methylcytosine dioxygenase TET1; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcription [...]
[a.k.a. XM_011540204, 80312, OMIM:607790]
4) '9606.ENSP00000479794':
H4C12 - H4 clustered histone 12.
[a.k.a. ENST00000611927, R-HSA-427359, 3A6N]
5) '9606.ENSP00000359292':
SLF2 - SMC5-SMC6 complex localization factor protein 2; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions ; Belongs to the FAM178 family.
[a.k.a. Q8IX21, ENSP00000238961, SLF2-202]
6) '9606.ENSP00000366956':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
7) '9606.ENSP00000181796':
FAM107B - Protein FAM107B; Family with sequence similarity 107 member B.
[a.k.a. ENSP00000420249, ENST00000378467.8, ENST00000378462]
8) '9606.ENSP00000265433':
NBN - Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]
[a.k.a. R-HSA-5633007, AT-V2, NBN-207]
9) '9606.ENSP00000334952':
ADGRA3 - Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
[a.k.a. ADGRA3-201, XM_011513811, ENST00000508133]
10) '9606.ENSP00000479461':
H4C4 - H4 clustered histone 4.
[a.k.a. R-HSA-427359, 3A6N, 3UVY]
11) '9606.ENSP00000265651':
FBXO3 - F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
[a.k.a. ENSP00000435165, ENST00000265651, F-box protein 3]
12) '9606.ENSP00000309233':
POMZP3 - POM121 and ZP3 fusion.
[a.k.a. U10099, POM (POM121 homolog, rat) and ZP3 fusion, ENST00000424818]
13) '9606.ENSP00000254898':
MATN2 - Matrilin-2; Involved in matrix assembly.
[a.k.a. A8K106, ENSP00000430487, UPI0001E8F2AA]
14) '9606.ENSP00000269187':
SLC39A6 - Zinc transporter ZIP6; May act as a zinc-influx transporter. Belongs to the ZIP transporter (TC 2.A.5) family.
[a.k.a. BAG61161.1, ZIP6, solute carrier family 39 member 6]
15) '9606.ENSP00000287394':
ATAD2 - ATPase family AAA domain-containing protein 2; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
[a.k.a. A0A0B4J211, 4TZ2, 4QST]
16) '9606.ENSP00000458954':
NUP88 - Nuclear pore complex protein Nup88; Component of nuclear pore complex.
[a.k.a. R-HSA-168333, NM_001320653, R-HSA-168271]
17) '9606.ENSP00000231509':
NR3C1 - Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand- dependent manner which recruits the RNA helicase UPF1 and the mRNA- decapping enzyme D [...]
[a.k.a. B0LPG8, AY436590, 3CLD]
18) '9606.ENSP00000332791':
KLHL15 - Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response, favoring DNA double-strand repair through e [...]
[a.k.a. NP_085127.2, 80311, Q32MN3]
19) '9606.ENSP00000345206':
RBPJ - Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling [...]
[a.k.a. ENST00000506903.1, uc003grx.3, R-HSA-5663202]
20) '9606.ENSP00000484789':
H4C5 - H4 clustered histone 5.
[a.k.a. R-HSA-427359, 3A6N, 3UVY]
101 query items
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