searching ... STRING: functional protein association networks

IL17RE - Interleukin-17 receptor E; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. [a.k.a. Q8TEC2, XM_011533361.3, IL17RE-207]

DTNA - Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. [a.k.a. XM_017025580.1, NM_032975, NM_032978.7]

MSANTD3 - Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family. [a.k.a. ENST00000374879, NP_001185736.1, Q5T726]

ADGRE5 - CD97 antigen subunit alpha; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity); Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. [a.k.a. K7EPE8, UPI0002840B4D, K7EKV5]

S100A14 - Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium. [a.k.a. Q9HCY8, AF426828, ENSG00000189334]

ABCD3 - ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched- chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity. [a.k.a. PMP70, EAW73050.1, PXMP1]

CNOT4 - CCR4-NOT transcription complex subunit 4; Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. [a.k.a. CHEMBL4105770, NP_037448.2, XM_024446772.1]

GOLGA8N - Golgin A8 family member N; Belongs to the GOLGA8 family. [a.k.a. golgin A8 family member N, Golgin subfamily A member 8N, F8WBI6]

POU2F2 - POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class-2 subfamily. [a.k.a. XM_005259010, uc002osn.4, ENST00000560804]

FBXO3 - F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. [a.k.a. ENSP00000435680, ENSG00000110429, ENSP00000435165]

TRIM17 - E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase. Belongs to the TRIM/RBCC family. [a.k.a. ENSG00000162931, ENST00000366697, NM_001024940]

OSBPL9 - Oxysterol binding protein like 9; Belongs to the OSBP family. [a.k.a. CCDS55598.1, oxysterol binding protein-like 9, ENSP00000354970]

KIF16B - Kinesin-like protein KIF16B; Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. Belongs to the TRAFAC class myosin-kines [...] [a.k.a. ENST00000635823.1, XM_017027926.1, XP_005260812.1]

CHUK - Inhibitor of nuclear factor kappa-B kinase subunit alpha; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into t [...] [a.k.a. 5TQW, R-HSA-9006925, conserved helix-loop-helix ubiquitous kinase]

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