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The following proteins in
Homo sapiens
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1) '9606.ENSP00000386306':
SCN9A - Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily.
[a.k.a. PN1, 6335, XM_011511617]
2) '9606.ENSP00000317379':
GLS - Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain ; Belongs to the glutaminase family.
[a.k.a. ENSP00000395596, 3VP1, URS0000D2DDCB]
3) '9606.ENSP00000441381':
MSLNL - Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family.
[a.k.a. H0YG18, ENSG00000162006, Mesothelin like]
4) '9606.ENSP00000302562':
HSPBAP1 - HSPB1-associated protein 1; May play a role in cellular stress response.
[a.k.a. BC063629, NM_024610, BC017763]
5) '9606.ENSP00000376786':
POU2AF1 - POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers; Belongs to the POU2AF1 family.
[a.k.a. XP_016873421.1, ENST00000530229.5, OBF1_HUMAN]
6) '9606.ENSP00000225792':
DDX5 - Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...]
[a.k.a. DDX5-206, ENSP00000225792, ENST00000583894.1]
7) '9606.ENSP00000362978':
EYA3 - Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX [...]
[a.k.a. R-HSA-5693565, BAG60409.1, eyes absent homolog 3 (Drosophila)]
8) '9606.ENSP00000357268':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
9) '9606.ENSP00000312277':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
10) '9606.ENSP00000453403':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
11) '9606.ENSP00000355778':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
12) '9606.ENSP00000271234':
FNBP1L - Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens; [...]
[a.k.a. NM_001164473, CCDS53343, NP_001157945.1]
13) '9606.ENSP00000228820':
PARP11 - Protein mono-ADP-ribosyltransferase PARP11; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity).
[a.k.a. XM_011520973.2, ENST00000476985, ENST00000427057]
14) '9606.ENSP00000310447':
GLS2 - Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
[a.k.a. 5U0K, GLS, AK289471]
15) '9606.ENSP00000326003':
PUS10 - Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.
[a.k.a. NP_653310.2, NM_144709.3, ENST00000316752]
16) '9606.ENSP00000318086':
MAP7D3 - MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules.
[a.k.a. NP_001166987.1, NM_001173517.1, HPA058101]
17) '9606.ENSP00000376335':
GPR155 - Integral membrane protein GPR155; G protein-coupled receptor 155.
[a.k.a. NP_001028217.1, AAO85040.1, ENST00000392551]
18) '9606.ENSP00000312021':
FUT1 - Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.
[a.k.a. KF906450, ENST00000599826.5, ENST00000599826]
19) '9606.ENSP00000334186':
VWCE - Von Willebrand factor C and EGF domain-containing protein; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma.
[a.k.a. URG11, AY205235, ENSG00000167992]
20) '9606.ENSP00000362702':
NEK6 - Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence.
[a.k.a. XM_024447387.1, XP_024303153, ENSG00000119408]
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