searching ... STRING: functional protein association networks

TSSK1B - Testis-specific serine/threonine-protein kinase 1; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. [a.k.a. TSSK-1, Testis-specific kinase 1, NP_114417.1]

METTL17 - Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family. [a.k.a. ENST00000554985, Methyltransferase-like protein 17, mitochondrial, METTL17-208]

LIMS4 - LIM and senescent cell antigen-like-containing domain protein 3; LIM zinc finger domain containing 4. [a.k.a. ENSP00000337266, NM_001371340.1, PINCH-3]

CDIPT - CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. [a.k.a. CDIPT-210, AK131349, Phosphatidylinositol synthase]

A2M - Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the c [...] [a.k.a. NM_001347424.1, URS00008BF993, R-HSA-162582]

ASMT - Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. [a.k.a. ENSP00000370627, NM_001171038.2, AAA75291.1]

EFCAB7 - EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia. [a.k.a. XR_001737487, XM_011542301.2, EF-hand calcium binding domain 7]

ANAPC1 - Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family. [a.k.a. ANAPC1-206, R-HSA-2555396, R-HSA-174084]

FBXO17 - F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins. [a.k.a. R-HSA-8951664, MGC9379, F-box only protein 26]

SLCO1B3 - Solute carrier organic anion transporter family member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver; Belongs to the organo anion transporter (TC 2.A.60) family. [a.k.a. NX_Q9NPD5, ENST00000544370, ENST00000545880]

TM4SF1 - Transmembrane 4 L six family member 1; Belongs to the L6 tetraspanin family. [a.k.a. UPI0000E5AA20, UPI000020A41D, ENST00000383054]

MEOX2 - Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle. [a.k.a. Growth arrest-specific homeobox, Mesenchyme homeobox 2, ENSP00000262041]

LIPC - Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. [a.k.a. EC 3.1.1.3, A2RUB4, M29190]

DMKN - Dermokine; May act as a soluble regulator of keratinocyte differentiation. [a.k.a. ABN11271.1, AAX48754.1, XP_006723547.1]

GABRR3 - Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. [a.k.a. ENST00000329044, ENST00000470589, NM_001105580.2]

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