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The following proteins in
Homo sapiens
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102 query items
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1) '9606.ENSP00000401303':
SHC1 - SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, [...]
[a.k.a. SHC-transforming protein 1, XP_024304851.1, R-HSA-9026519]
2) '9606.ENSP00000265857':
GET4 - Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of [...]
[a.k.a. GET4-201, ENST00000464468.1, CGI-20]
3) '9606.ENSP00000402033':
PDZD2 - Processed PDZ domain-containing protein 2; PDZ domain containing 2.
[a.k.a. PDZD2-210, AB002298, XP_011512294]
4) '9606.ENSP00000267415':
TINF2 - TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
[a.k.a. NM_012461.2, XP_016876705, R-HSA-1474165]
5) '9606.ENSP00000398083':
TMEM243 - Transmembrane protein 243; Belongs to the TMEM243 family.
[a.k.a. AK313794, AC005076, NM_001329475.1]
6) '9606.ENSP00000330509':
- - Sorry, STRING found no proteins by this name in Homo sapiens - -
7) '9606.ENSP00000382982':
TUBA3C - Tubulin alpha 3c.
[a.k.a. R-HSA-2555396, ENST00000355310, AK292253]
8) '9606.ENSP00000482674':
H2BC3 - Histone H2B type 1-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
[a.k.a. R-HSA-5693565, R-HSA-5619507, R-HSA-69278]
9) '9606.ENSP00000305852':
TM4SF4 - Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
[a.k.a. OMIM:606567, TM4SF4-202, CH471052]
10) '9606.ENSP00000257663':
TMEM60 - Transmembrane protein 60.
[a.k.a. hsa:85025, AF260336, C7orf35]
11) '9606.ENSP00000289228':
ACTR1B - Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.
[a.k.a. XM_005263854.5, NP_005726.1, P42025]
12) '9606.ENSP00000326042':
TUBA3D - Detyrosinated tubulin alpha-3C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
[a.k.a. R-HSA-2555396, NP_005992.1, AK292253]
13) '9606.ENSP00000216727':
PABPN1 - Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length (By similarity). Increases the affinity of poly(A) polymerase for RNA (By similarity). Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to syner [...]
[a.k.a. D3DS49, R-HSA-168254, NM_004643.3]
14) '9606.ENSP00000364028':
ECE1 - Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1. Belongs to the peptidase M13 family.
[a.k.a. D49471, BAG65053.1, ENSP00000364028]
15) '9606.ENSP00000312439':
RNF26 - E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle- associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating th [...]
[a.k.a. 79102, NP_114404, ENST00000311413.4]
16) '9606.ENSP00000387100':
TPRN - Taperin.
[a.k.a. ENSG00000176058, NP_001121700.2, TPRN-203]
17) '9606.ENSP00000401907':
BMPR1B - Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.
[a.k.a. ENST00000512312.5, BMR1B_HUMAN, R-HSA-162582]
18) '9606.ENSP00000351926':
AP2A1 - AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold [...]
[a.k.a. OTTHUMG00000183253, CCDS46148, ENST00000413690]
19) '9606.ENSP00000338860':
ZNF444 - Zinc finger protein 444; Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family.
[a.k.a. Q8N0Y2, EZF2, XP_005259093.1]
20) '9606.ENSP00000370129':
AKR1C2 - Aldo-keto reductase family 1 member C2; Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5- beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha- androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.
[a.k.a. P52895, ENSP00000397161, uc057rik.1]
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