searching ... STRING: functional protein association networks

TDO2 - Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. [a.k.a. 6A4I, TDO, ENSG00000151790]

SPANXN5 - Sperm protein associated with the nucleus on the X chromosome N5; SPANX family member N5; Belongs to the SPAN-X family. [a.k.a. SPANX-N5, Q5MJ07, CT11.10]

AFM - Afamin; Functions as carrier for hydrophobic molecules in body fluids (Probable). Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier. Belongs to the ALB/AFP/VDB family. [a.k.a. NP_001124.1, XM_017007843, XP_016863333.1]

DPP10 - Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity. [a.k.a. ENSP00000376854, ENST00000476155, NP_001308834.2]

SLC34A1 - Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx; Belongs to the SLC34A transporter family. [a.k.a. CHEMBL3769299, FRTS2, ENST00000512593.5]

TXNDC8 - Thioredoxin domain-containing protein 8; May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm. [a.k.a. NP_001273875, XM_017014581, ENSP00000363635]

F9 - Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. Belongs to the peptidase S1 family. [a.k.a. ENST00000394090, J00136, R-HSA-140834]

PRODH - Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. [a.k.a. uc002zok.5, Proline dehydrogenase, ENST00000399694]

RAPGEF5 - Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. [a.k.a. 9771, ENST00000401957, NP_036426]

RAB43 - Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga [...] [a.k.a. RAB43-204, RAB41, A8K4P9]

MUC3A - Mucin-3A; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling. [a.k.a. AF007193, MUC3A-204, A0A182DWF7]

LRRC73 - Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73. [a.k.a. C6orf154, 221424, NP_001012992.1]

CCL21 - C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. [a.k.a. NX_O00585, R-HSA-388396, NP_002980.1]

HRG - Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell [...] [a.k.a. NP_000403, AAI50592.1, XP_005247472]

FCRL4 - Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. [a.k.a. AF397452, CD307d, 83417]

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