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bepA bepA mutY mutY bamC bamC hcr hcr cca cca yggN yggN yiaM yiaM tufA tufA yhjJ yhjJ yfgD yfgD greA greA ygiM ygiM lhr lhr lpxD lpxD lgoR lgoR fadM fadM yqjA yqjA yraP yraP ftnB ftnB sgbU sgbU yiaN yiaN lyxK lyxK rpoH rpoH bamD bamD lpxP lpxP yiaO yiaO psd psd hcp hcp yiaK yiaK gspA gspA ytfJ ytfJ mscM mscM insK insK degP degP recJ recJ mzrA mzrA sgbE sgbE ahpF ahpF ibaG ibaG yfeX yfeX eptB eptB ybdG ybdG sgbH sgbH ecpR ecpR prfB prfB fusA fusA gspB gspB plsB plsB dsbC dsbC yfeY yfeY malQ malQ yiaL yiaL
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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bepAOM protein maintenance and assembly metalloprotease and chaperone, periplasmic; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state. Promotes disulfide rearrangement of LptD during its biogenesis, and proteolytic degradation of LptD and BamA when their proper assembly is compromised. May facilitate membrane attachment of LoiP under unfavorable conditions; Belongs to the peptidase M48 family. BepA subfamily. (487 aa)
mutYAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family. (350 aa)
bamCBamABCDE complex OM biogenesis lipoprotein; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex that stabilizes the interaction between the essential proteins BamA and BamD. Efficient substrate folding and insertion into the outer membrane requires all 5 subunits. A lateral gate may open between the first and last strands of the BamA beta-barrel that allows substrate to insert into the outer membrane; comparison of the structures of complete and nearly [...] (344 aa)
hcrHCP oxidoreductase, NADH-dependent; NADH oxidoreductase acting in concert with HCP. (322 aa)
ccaFused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi. Displays a metal-independent [...] (412 aa)
yggNDUF2884 family putative periplasmic protein. (239 aa)
yiaM2,3-diketo-L-gulonate TRAP transporter small permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. (157 aa)
tufATranslation elongation factor EF-Tu 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Plays a stimulatory role in trans-translation; binds tmRNA. (Microbial infection) Upon infection by bacteriophage Qbeta, part of the viral RNA-dependent RNA polymerase complex. With EF-Ts may provide a stabilizing scaffold for the beta (catalytic) subunit. Helps separate the double-stranded RNA of the template and growing RNA during elongation. With the beta subunit helps form the exit tunnel for template RNA. (Microbial infe [...] (394 aa)
yhjJPutative periplasmic M16 family chaperone; Belongs to the peptidase M16 family. (498 aa)
yfgDPutative oxidoreductase; Protein involved in xenobiotic metabolic process; Belongs to the ArsC family. (119 aa)
greATranscript cleavage factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa)
ygiMSH3 domain protein. (206 aa)
lhrMember of ATP-dependent helicase superfamily II; Protein involved in DNA-dependent DNA replication; Belongs to the helicase family. (1538 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O- (hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Prefers (3R)-3-hydroxytetradecanoyl-ACP over (3R)-3-hydroxyhexadecanoyl-ACP as the acyl donor in vitro, which is consistent with the structure of E.coli lipid A that contains over 95% (R)-3-hydroxytetradecanoate at the 2 and 2' positions. Belongs to the transferase [...] (341 aa)
lgoRPutative transcriptional activator for L-galactonate catabolism; May be a positive transcriptional regulator for lgoD and/or lgoT. Is essential for growth on L-galactonate as the sole carbon source. (304 aa)
fadMLong-chain acyl-CoA thioesterase III; Long-chain acyl-CoA thioesterase with a preference for 3,5- tetradecadienoyl-CoA. Could be involved in beta-oxidation of fatty acids; Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. (132 aa)
yqjAGeneral envelope maintenance protein; May be a membrane transporter required for proton motive force (PMF)-dependent drug efflux. Required, with YghB, for the proper export of certain periplasmic amidases and, possibly, other Tat substrates. May play a role in determining membrane lipid composition. Belongs to the DedA family. (220 aa)
yraPOuter membrane lipoprotein; Putative periplasmic protein. (191 aa)
ftnBFerritin B, putative ferrous iron reservoir; Ferritin-like protein; Protein involved in iron ion transport. (167 aa)
sgbUPutative L-xylulose 5-phosphate 3-epimerase; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate (Potential). May be involved in the utilization of 2,3-diketo-L-gulonate; Belongs to the L-ribulose-5-phosphate 3-epimerase family. (286 aa)
yiaN2,3-diketo-L-gulonate TRAP transporter large permease protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. (425 aa)
lyxKL-xylulose kinase; Catalyzes the phosphorylation of L-xylulose and 3-keto-L- gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate. (498 aa)
rpoHRNA polymerase, sigma 32 (sigma H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane functionality and homeostasis. RpoH is then quic [...] (284 aa)
bamDBamABCDE complex OM biogenesis lipoprotein; Part of the outer membrane protein assembly complex (Bam), which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. Probably involved in transient protein interactions. Efficient substrate folding and insertion into the outer membrane requires all 5 subunits. A lateral gate may open between the first and last strands of the BamA beta-barrel that allows substrate to insert into the outer membrane; comparison of the structures of complete a [...] (245 aa)
lpxPPalmitoleoyl-acyl carrier protein (ACP)-dependent acyltransferase; Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (palmitoleoyl)-lipid IV(A). Required for the biosynthesis of a distinct molecular species of lipid A, which is present only in cells grown at low temperatures. It may confer a selective advantage to cells growing at lower temperatures by making the outer membrane a more effective barrier to harmful chemicals. (306 aa)
yiaO2,3-diketo-L-gulonate-binding periplasmic protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L- gulonate. This protein specifically binds 2,3-diketo-L-gulonate. Is not able to bind either L-ascorbate or dehydroascorbate. Belongs to the bacterial solute-binding protein 7 family. (328 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Only decarboxylates the lipid-linked form of the serine moiety, and not serine alone or derivatives like phosphoserine or glycerophosphoserine. (322 aa)
hcpHybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. Is also able to reduce hydroxylamine analogs such as methylhydroxylamine and hydroxyquinone. Might have a role as a scavenger of potentially toxic by-products of nitrate metabolism. Belongs to the HCP family. (550 aa)
yiaK2,3-diketo-L-gulonate reductase, NADH-dependent; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate. (332 aa)
gspAGeneral secretory pathway component, cryptic; May play a regulatory role under conditions of derepressed gsp gene expression; Belongs to the ExeA family. (489 aa)
ytfJPutative transcriptional regulator. (184 aa)
mscMMechanosensitive channel protein, miniconductance; Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension. (1107 aa)
insKIS150 transposase B; Involved in the transposition of the insertion sequence IS150; Belongs to the transposase IS3/IS150/IS904 family. (283 aa)
degPSerine endoprotease (protease Do), membrane-associated; DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. Degrades transiently denatured and unfolded or misfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. [...] (474 aa)
recJssDNA exonuclease, 5' --> 3'-specific; Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available. (577 aa)
mzrAModulator of EnvZ/OmpR regulon; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR. Belongs to the MzrA family. (127 aa)
sgbEL-ribulose-5-phosphate 4-epimerase; Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). May be involved in the utilization of 2,3-diketo-L-gulonate. (231 aa)
ahpFAlkyl hydroperoxide reductase, F52a subunit, FAD/NAD(P)-binding; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (521 aa)
ibaGAcid stress protein; Involved in cell resistance against acid stress. (84 aa)
yfeXPorphyrinogen oxidase, cytoplasmic; Has both general peroxidase activity and dye-decolorizing activity. Can catalyze the oxidation of both protoporphyrinogen IX and coproporphyrinogen III to their corresponding porphyrins. Also efficiently decolorizes the dyes alizarin red and Cibacron blue F3GA. (299 aa)
eptBKDO phosphoethanolamine transferase, Ca(2+)-inducible; Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol; Belongs to the phosphoethanolamine transferase family. EptB subfamily. (563 aa)
ybdGMechanosensitive channel protein, miniconductance; Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks. (415 aa)
sgbH3-keto-L-gulonate 6-phosphate decarboxylase; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P. May be involved in the utilization of 2,3-diketo-L- gulonate. (220 aa)
ecpRPutative transcriptional regulator for the ecp operon; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP is found in both commensal and pathogenic strains and plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity). Also represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon (Probable); Belongs to the EcpR/MatA family. (196 aa)
prfBPeptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Acts as a peptidyl-tRNA hydrolase. In the presence of truncated mRNA in the 70S ribosome, ArfA and RF2 interact such that the GGQ peptide hydrolysis motif of RF2 rises into the peptidyl-transferase center and releases the ribosome. Recruited by ArfA to rescue stalled ribosomes in the absence of a normal stop codon. (365 aa)
fusAProtein chain elongation factor EF-G, GTP-binding; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase f [...] (704 aa)
gspBPart of gsp divergon involved in type II protein secretion; Part of a cryptic operon that encodes proteins involved in type II secretion pathway in other organisms, but is not expressed in strain K12 under standard laboratory conditions. May play a regulatory role under conditions of derepressed gsp gene expression. (139 aa)
plsBGlycerol-3-phosphate O-acyltransferase; Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor. Belongs to the GPAT/DAPAT family. (807 aa)
dsbCProtein disulfide isomerase II; Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD. (236 aa)
yfeYRpoE-regulated lipoprotein. (191 aa)
malQ4-alpha-glucanotransferase (amylomaltase); Protein involved in carbohydrate catabolic process and polysaccharide catabolic process; Belongs to the disproportionating enzyme family. (694 aa)
yiaLDUF386 family protein; Putative lipase; Belongs to the TabA/YhcH/YiaL family. (155 aa)
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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