searching ... STRING: functional protein association networks

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The following proteins in Homo sapiens appear to match your input.
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101 query items

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1) '9606.ENSP00000343818':

CDK5RAP2 - CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of [...] [a.k.a. ENSP00000400395, XM_017014921, URS0000D6E521]

2) '9606.ENSP00000206544':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

3) '9606.ENSP00000325817':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

4) '9606.ENSP00000393559':

PACS2 - Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinc [...] [a.k.a. NP_001094383.2, F8W0B1, XP_016876601]

5) '9606.ENSP00000345008':

FBLN5 - Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN. Belongs to the fibulin family. [a.k.a. R-HSA-2129379, ENST00000557088.5, ENST00000554121]

6) '9606.ENSP00000257895':

RDH5 - Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates. Belongs to the short-chain dehydrogenases/reductases (SDR) family. [a.k.a. ENST00000550608.1, R-HSA-388396, RDH5-204]

7) '9606.ENSP00000283243':

PLA2R1 - Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the p [...] [a.k.a. Soluble PLA2R, NM_001007267, ENSP00000376524]

8) '9606.ENSP00000242480':

EGR2 - E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Belongs to the EGR C2H2-type zinc-finger protein family. [a.k.a. ENST00000437594, URS0000EABDF3, hsa:1959]

9) '9606.ENSP00000434939':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

10) '9606.ENSP00000257857':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

11) '9606.ENSP00000295324':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

12) '9606.ENSP00000395328':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

13) '9606.ENSP00000362308':

SH3BGRL - SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like. [a.k.a. ENSP00000253481, uc004eef.4, HPA051248]

14) '9606.ENSP00000386043':

LTBP1 - Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta. Belongs to the LTBP family. [a.k.a. R-HSA-2129379, ENST00000261356, AAY14953.1]

15) '9606.ENSP00000295958':

SMIM14 - Small integral membrane protein 14. [a.k.a. LOC201895, UPI00000420ED, ENST00000512441]

16) '9606.ENSP00000280258':

PRSS23 - Serine protease 23; Belongs to the peptidase S1 family. [a.k.a. NP_001280109.1, AF015287, PRSS23-204]

17) '9606.ENSP00000339826':

PIK3AP1 - Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival o [...] [a.k.a. PIK3AP1-206, R-HSA-9006925, R-HSA-983705]

18) '9606.ENSP00000403975':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

19) '9606.ENSP00000354219':

- - Sorry, STRING found no proteins by this name in Homo sapiens - -

20) '9606.ENSP00000357307':

SYT11 - Synaptotagmin-11; Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+). Inhibits clathrin- mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of a [...] [a.k.a. AAH39205.1, ENST00000368324, CCDS1122]

101 query items

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