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There are several matches for 'Shh'.
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331 matches
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organism
protein
1)
Homo sapiens
SHH
- Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity).
2)
Mus musculus
Shh
- Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum.
3)
Homo sapiens
ULK3 - Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (
SHH
) signaling and autophagy. Acts as a negative regulator of
SHH
signaling in the absence of
SHH
ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates
SHH
signaling in the presence of
SHH
: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...]
[a.k.a. 6FDZ, UPI00000558DB, 6FDY]
4)
Homo sapiens
GPR161 - G-protein coupled receptor 161; Key negative regulator of
Shh
signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in
Shh
signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the
Shh
signaling. In presence of
SHH
, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the
Shh
signalin [...]
[a.k.a. XM_011509376.2, NM_001267610.1, ENSP00000315981]
5)
Homo sapiens
HSPB11 - Intraflagellar transport protein 25 homolog; Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of
SHH
components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the
SHH
pathway, suggesting it is involved in the dynamic transport of
SHH
signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male ferti [...]
[a.k.a. HPA030140, ENST00000371377.3, C1orf41]
6)
Homo sapiens
SCUBE2 - Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for
SHH
long-range signaling by binding to the dually lipid-modified
SHH
(ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase
SHH
secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
[a.k.a. NM_001170690.2, NP_066025.2, XP_005253094.2]
7)
Homo sapiens
KIF7 - Kinesin-like protein KIF7; Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (
Shh
) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU- dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes (By similarity). Required for localization of GLI3 to cilia in response to
Shh
. Negatively regulates
Shh
signaling by preventing inappropriate activation of the tran [...]
[a.k.a. BC104044, ENST00000558928.1, JBTS12]
8)
Homo sapiens
GLI1 - Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates
SHH
signaling. Plays a role in cell proliferation and differentiation via its role in
SHH
signaling. Belongs to the GLI C2H2-type zinc-finger protein family.
[a.k.a. ENST00000546141.5, 2735, ENSP00000436671]
9)
Homo sapiens
SIX3 - Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of
SHH
expression in the rostral diencephalon ventral midline and that in turn
SHH
maintains its expression. In addition, Six3 activity is re [...]
[a.k.a. AF092047, ENST00000260653.4, OTTHUMG00000152424]
10)
Homo sapiens
CDK20 - Cyclin-dependent kinase 20; Required for high-level
Shh
responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to
SHH
signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
[a.k.a. NP_001164110.1, CDCH, NP_848519.1]
11)
Homo sapiens
IRX3 - Iroquois-class homeodomain protein IRX-3; Transcription factor involved in
SHH
-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by
SHH
signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism.
[a.k.a. AY335942, hsa:79191, XM_005256139.3]
12)
Homo sapiens
ACTRT1 - Actin-related protein T1; Negatively regulates the Hedgehog (
SHH
) signaling. Binds to the promoter of the
SHH
signaling mediator, GLI1, and inhibits its expression; Belongs to the actin family.
[a.k.a. NX_Q8TDG2, ENSP00000360165, Q8TDG2]
13)
Homo sapiens
TULP3 - Tubby-related protein 3; Negative regulator of the
Shh
signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in
Shh
signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis; Belongs to the TUB family.
[a.k.a. ENSP00000443709, R-HSA-162582, ENST00000544943]
14)
Homo sapiens
TBC1D32 - Protein broad-minded; Required for high-level
Shh
responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to
Shh
signaling (By similarity).
[a.k.a. AK131446, XR_001743232.2, AK055461]
15)
Homo sapiens
HHAT - Protein-cysteine N-palmitoyltransferase HHAT; Catalyzes N-terminal palmitoylation of
SHH
; which is required for
SHH
signaling. May bind GTP; Belongs to the membrane-bound acyltransferase family. HHAT subfamily.
[a.k.a. NM_018194.6, AK316190, ENSP00000442625]
16)
Homo sapiens
IFT81 - Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of
SHH
signaling. Belongs to the IFT81 family.
[a.k.a. UPI00020CE46C, ENST00000551055.1, ENST00000242591.9]
17)
Homo sapiens
TTC21B - Tetratricopeptide repeat protein 21B; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Essential for retrograde trafficking of IFT- 1, IFT-B and GPCRs. Negatively modulates the
SHH
signal transduction (By similarity); Belongs to the TTC21 family.
[a.k.a. CCDS33315.1, XP_006712824.1, R-HSA-162582]
18)
Homo sapiens
SMO - Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (
SHH
) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).
[a.k.a. CRJS, Protein Gx, 4O9R]
19)
Homo sapiens
DISP1 - Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause an increase in
SHH
secretion ; Belongs to the dispatched family.
[a.k.a. DISPA, XP_011508376.1, NX_Q96F81]
20)
Homo sapiens
STK36 - Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (
Shh
) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...]
[a.k.a. Q9ULE2, XM_011510960, ENSG00000163482]
331 matches
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