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7080 matches
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organism
protein
1)
Homo sapiens
RIF1 - Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (
DSBs
) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of
DSBs
. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA
DSBs
. Once recruited to
DSBs
, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of
DSBs
. In the s [...]
[a.k.a. CCDS2194.1, AAV51403.1, RIF1-212]
2)
Homo sapiens
TP53BP1 - TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (
DSBs
) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of
DSBs
and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to
DSBs
, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to
DSBs
s [...]
[a.k.a. R-HSA-5693565, 6IU7, R-HSA-69620]
3)
Homo sapiens
RNF169 - E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (
DSBs
) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of
DSBs
repair. E3 ubiquitin-protein ligase activity is not required for regulation of
DSBs
repair.
[a.k.a. HPA058368, ENSP00000299563, Q8NCN4]
4)
Homo sapiens
ATM - Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (
DSBs
), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (
DSBs
), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...]
[a.k.a. XM_017017792, ATM-212, M0QXY8]
5)
Homo sapiens
PIF1 - ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (
DSBs
) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to
DSBs
via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]
[a.k.a. PIF1/RRM3 DNA helicase-like protein, OMIM:610953, UPI00005DB2E0]
6)
Homo sapiens
REC114 - Meiotic recombination protein REC114; Required for DNA double-strand breaks (
DSBs
) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates
DSBs
formation in unsynapsed regions, an essential step to ensure completion of synapsis; Belongs to the REC114 family.
[a.k.a. LOC283677, C15orf60, ENST00000560581.1]
7)
Homo sapiens
SMARCAD1 - ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (
DSBs
) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking
DSBs
. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restorat [...]
[a.k.a. B7Z799, AC096746, AK027490]
8)
Homo sapiens
BABAM1 - BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (
DSBs
). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at
DSBs
. Component of the BRISC complex, a multiprotein complex that specifically cl [...]
[a.k.a. 6H3C, ENST00000595632, AAH00788.1]
9)
Homo sapiens
RNF8 - E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (
DSBs
) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA
DSBs
, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]
[a.k.a. R-HSA-5693565, R-HSA-69620, 2CSW]
10)
Homo sapiens
DCLRE1C - Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (
DSBs
). These
DSBs
present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and [...]
[a.k.a. XR_001747185, NP_001029027.1, ENST00000418843]
11)
Homo sapiens
RBBP8 - DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs
DSBs
resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to
DSBs
in the S/G2 phas [...]
[a.k.a. CtBP-interacting protein, COM1, XP_006722584]
12)
Homo sapiens
CCDC36 - Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (
DSBs
) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates
DSBs
formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.
[a.k.a. ENST00000336384, Q8IYA8, ENSP00000391788]
13)
Homo sapiens
MEI4 - Meiosis-specific protein MEI4; Required for DNA double-strand breaks (
DSBs
) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates
DSBs
formation in unsynapsed regions, an essential step to ensure completion of synapsis.
[a.k.a. R4GMV8, OTTHUMG00000153472, ENSP00000473370]
14)
Homo sapiens
SLF1 - SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (
DSBs
) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions.
[a.k.a. ENST00000508130, ENST00000504099, Q9BQI6]
15)
Homo sapiens
ANKRD31 - Ankyrin repeat domain-containing protein 31; Required for DNA double-strand breaks (
DSBs
) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes.
[a.k.a. OMIM:618423, XM_017009319.1, XM_011543301.3]
16)
Homo sapiens
NIPBL - Nipped-B-like protein; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double- strand breaks (
DSBs
) sites occurs in a CBX3-, RNF8- and RNF168- dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration d [...]
[a.k.a. NM_015384, NIPBL-201, 25836]
17)
Homo sapiens
SHLD2 - Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (
DSBs
). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres ; Belongs to the SHLD2 family.
[a.k.a. XP_011538179, FAM35A, OTTHUMG00000018669]
18)
Homo sapiens
SHLD1 - Shieldin complex subunit 1; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (
DSBs
). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.
[a.k.a. RINN3, A8K9J3, ENST00000445603]
19)
Homo sapiens
MEIOB - Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (
DSBs
) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...]
[a.k.a. NX_Q8N635, Q8N635, ENSP00000457416]
20)
Homo sapiens
RNF168 - E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (
DSBs
) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]
[a.k.a. NP_689830.2, R-HSA-5693565, R-HSA-69620]
7080 matches
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