| ARF5 protein network | https://string-db.org/network/9606.ENSP00000000233 | ADP-ribosylation factor 5; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may m [...] |
| M6PR protein network | https://string-db.org/network/9606.ENSP00000000412 | Cation-dependent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl re [...] |
| FKBP4 protein network | https://string-db.org/network/9606.ENSP00000001008 | Peptidyl-prolyl cis-trans isomerase FKBP4; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein [...] |
| CYP26B1 protein network | https://string-db.org/network/9606.ENSP00000001146 | Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic [...] |
| NDUFAF7 protein network | https://string-db.org/network/9606.ENSP00000002125 | Protein arginine methyltransferase NDUFAF7, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Ac [...] |
| FUCA2 protein network | https://string-db.org/network/9606.ENSP00000002165 | Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoprote [...] |
| HS3ST1 protein network | https://string-db.org/network/9606.ENSP00000002596 | Heparan sulfate glucosamine 3-O-sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine res [...] |
| SEMA3F protein network | https://string-db.org/network/9606.ENSP00000002829 | Semaphorin-3F; May play a role in cell motility and cell adhesion; Immunoglobulin like domain containing |
| CFTR protein network | https://string-db.org/network/9606.ENSP00000003084 | Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates th [...] |
| CYP51A1 protein network | https://string-db.org/network/9606.ENSP00000003100 | Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol; it transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol; Cytochrome P450 family 51 |
| USP28 protein network | https://string-db.org/network/9606.ENSP00000003302 | Ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deub [...] |
| SLC7A2 protein network | https://string-db.org/network/9606.ENSP00000004531 | Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between is [...] |
| PDK4 protein network | https://string-db.org/network/9606.ENSP00000005178 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation [...] |
| USH1C protein network | https://string-db.org/network/9606.ENSP00000005226 | Harmonin; Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for nor [...] |
| RALA protein network | https://string-db.org/network/9606.ENSP00000005257 | Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane [...] |
| BAIAP2L1 protein network | https://string-db.org/network/9606.ENSP00000005260 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganiz [...] |
| CACNG3 protein network | https://string-db.org/network/9606.ENSP00000005284 | Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes thei [...] |
| TMEM132A protein network | https://string-db.org/network/9606.ENSP00000005286 | Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-i [...] |
| DVL2 protein network | https://string-db.org/network/9606.ENSP00000005340 | Segment polarity protein dishevelled homolog DVL-2; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling [...] |
| RPAP3 protein network | https://string-db.org/network/9606.ENSP00000005386 | RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to r [...] |
| SKAP2 protein network | https://string-db.org/network/9606.ENSP00000005587 | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a r [...] |
| PRSS21 protein network | https://string-db.org/network/9606.ENSP00000005995 | Testisin; Could regulate proteolytic events associated with testicular germ cell maturation; Serine proteases |
| HOXA11 protein network | https://string-db.org/network/9606.ENSP00000006015 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| CX3CL1 protein network | https://string-db.org/network/9606.ENSP00000006053 | Fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1. Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independ [...] |
| TRAPPC6A protein network | https://string-db.org/network/9606.ENSP00000006275 | Trafficking protein particle complex subunit 6A; May play a role in vesicular transport during the biogenesis of melanosomes; Trafficking protein particle complex |
| WDR54 protein network | https://string-db.org/network/9606.ENSP00000006526 | WD repeat-containing protein 54; WD repeat domain containing |
| SPATA20 protein network | https://string-db.org/network/9606.ENSP00000006658 | Spermatogenesis-associated protein 20; May play a role in fertility regulation |
| CEACAM7 protein network | https://string-db.org/network/9606.ENSP00000006724 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| RHBDD2 protein network | https://string-db.org/network/9606.ENSP00000006777 | Rhomboid domain containing 2; Belongs to the peptidase S54 family |
| TSR3 protein network | https://string-db.org/network/9606.ENSP00000007390 | Ribosome biogenesis protein TSR3 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis |
| OSBPL7 protein network | https://string-db.org/network/9606.ENSP00000007414 | Oxysterol-binding protein-related protein 7; Pleckstrin homology domain containing; Belongs to the OSBP family |
| YBX2 protein network | https://string-db.org/network/9606.ENSP00000007699 | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box cons [...] |
| ITGA3 protein network | https://string-db.org/network/9606.ENSP00000007722 | Integrin alpha-3; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) [...] |
| KRT33A protein network | https://string-db.org/network/9606.ENSP00000007735 | Keratin, type I cuticular Ha3-I; Keratins, type I; Belongs to the intermediate filament family |
| TFAP2D protein network | https://string-db.org/network/9606.ENSP00000008391 | Transcription factor AP-2-delta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...] |
| CRY1 protein network | https://string-db.org/network/9606.ENSP00000008527 | Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes thr [...] |
| PGLYRP1 protein network | https://string-db.org/network/9606.ENSP00000008938 | Peptidoglycan recognition protein 1; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...] |
| STARD3NL protein network | https://string-db.org/network/9606.ENSP00000009041 | STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic [...] |
| CAMK1G protein network | https://string-db.org/network/9606.ENSP00000009105 | Calcium/calmodulin-dependent protein kinase type 1G; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription [...] |
| CD74 protein network | https://string-db.org/network/9606.ENSP00000009530 | HLA class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after [...] |
| FAM76A protein network | https://string-db.org/network/9606.ENSP00000010299 | X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; Family with sequence similarity 76 member A |
| CPA1 protein network | https://string-db.org/network/9606.ENSP00000011292 | Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro; Belongs to the peptidase M14 family |
| SYPL1 protein network | https://string-db.org/network/9606.ENSP00000011473 | Synaptophysin-like protein 1; Synaptophysin like 1; Belongs to the synaptophysin/synaptobrevin family |
| RANBP9 protein network | https://string-db.org/network/9606.ENSP00000011619 | Ran-binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HG [...] |
| CD4 protein network | https://string-db.org/network/9606.ENSP00000011653 | T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal o [...] |
| TSPAN9 protein network | https://string-db.org/network/9606.ENSP00000011898 | Tetraspanin-9; Tetraspanin 9; Belongs to the tetraspanin (TM4SF) family |
| QPCTL protein network | https://string-db.org/network/9606.ENSP00000012049 | Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides |
| PPP5C protein network | https://string-db.org/network/9606.ENSP00000012443 | Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1 [...] |
| UBR7 protein network | https://string-db.org/network/9606.ENSP00000013070 | Putative E3 ubiquitin-protein ligase UBR7; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that a [...] |
| MAP4K5 protein network | https://string-db.org/network/9606.ENSP00000013125 | Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway; Mitogen-activated protein [...] |
| INMT protein network | https://string-db.org/network/9606.ENSP00000013222 | Indolethylamine N-methyltransferase; Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-meth [...] |
| ERCC1 protein network | https://string-db.org/network/9606.ENSP00000013807 | DNA excision repair protein ERCC-1; Isoform 1: Non-catalytic component of a structure- specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunct [...] |
| GPRC5A protein network | https://string-db.org/network/9606.ENSP00000014914 | Retinoic acid-induced protein 3; Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provide eviden [...] |
| HEBP1 protein network | https://string-db.org/network/9606.ENSP00000014930 | Heme-binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of [...] |
| COX15 protein network | https://string-db.org/network/9606.ENSP00000016171 | Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A; Mitochondrial respiratory chain complex assembly factors |
| MS4A12 protein network | https://string-db.org/network/9606.ENSP00000016913 | Membrane-spanning 4-domains subfamily A member 12; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family |
| RGPD5 protein network | https://string-db.org/network/9606.ENSP00000016946 | RANBP2-like and GRIP domain containing 5; Tetratricopeptide repeat domain containing |
| XYLT2 protein network | https://string-db.org/network/9606.ENSP00000017003 | Xylosyltransferase 2; Involved in the formation of heparan sulfate and chondroitin sulfate proteoglycans. Probably catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylos [...] |
| SCTR protein network | https://string-db.org/network/9606.ENSP00000019103 | Secretin receptor; This is a receptor for secretin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Glucagon receptor family |
| RALBP1 protein network | https://string-db.org/network/9606.ENSP00000019317 | RalA-binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxor [...] |
| PSD protein network | https://string-db.org/network/9606.ENSP00000020673 | PH and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling (By similarity); Belongs to the PSD family |
| SYT13 protein network | https://string-db.org/network/9606.ENSP00000020926 | Synaptotagmin-13; May be involved in transport vesicle docking to the plasma membrane; Belongs to the synaptotagmin family |
| SLC7A9 protein network | https://string-db.org/network/9606.ENSP00000023064 | B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be respo [...] |
| RTFDC1 protein network | https://string-db.org/network/9606.ENSP00000023939 | Protein RTF2 homolog; Replication termination factor 2 domain containing 1; Belongs to the rtf2 family |
| RB1CC1 protein network | https://string-db.org/network/9606.ENSP00000025008 | RB1-inducible coiled-coil protein 1; Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the format [...] |
| AKAP11 protein network | https://string-db.org/network/9606.ENSP00000025301 | A-kinase anchor protein 11; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; Belongs to the AKAP110 family |
| PIGQ protein network | https://string-db.org/network/9606.ENSP00000026218 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...] |
| CDH17 protein network | https://string-db.org/network/9606.ENSP00000027335 | Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| B4GALT7 protein network | https://string-db.org/network/9606.ENSP00000029410 | Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glyc [...] |
| FAM13B protein network | https://string-db.org/network/9606.ENSP00000033079 | Protein FAM13B; Family with sequence similarity 13 member B; Rho GTPase activating proteins |
| CHPF2 protein network | https://string-db.org/network/9606.ENSP00000035307 | Chondroitin sulfate glucuronyltransferase; Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N- acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has n [...] |
| LRRC7 protein network | https://string-db.org/network/9606.ENSP00000035383 | Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N- [...] |
| GABARAPL2 protein network | https://string-db.org/network/9606.ENSP00000037243 | Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAR [...] |
| MYOC protein network | https://string-db.org/network/9606.ENSP00000037502 | Myocilin; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskele [...] |
| FAM136A protein network | https://string-db.org/network/9606.ENSP00000037869 | Protein FAM136A; Family with sequence similarity 136 member A; Belongs to the FAM136 family |
| OTC protein network | https://string-db.org/network/9606.ENSP00000039007 | Ornithine carbamoyltransferase, mitochondrial; Ornithine carbamoyltransferase; Belongs to the ATCase/OTCase family |
| TTC17 protein network | https://string-db.org/network/9606.ENSP00000039989 | Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization; Tetratricopeptide repeat domain containing |
| HOXC8 protein network | https://string-db.org/network/9606.ENSP00000040584 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| MRI1 protein network | https://string-db.org/network/9606.ENSP00000040663 | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic acti [...] |
| BOD1L1 protein network | https://string-db.org/network/9606.ENSP00000040738 | Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent [...] |
| TARBP1 protein network | https://string-db.org/network/9606.ENSP00000040877 | Probable methyltransferase TARBP1; Probable S-adenosyl-L-methionine-dependent methyltransferase which methylates RNA molecules such as tRNAs. In case of infection by HIV-1, it binds to the loop r [...] |
| RTN4R protein network | https://string-db.org/network/9606.ENSP00000043402 | Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans (By [...] |
| PSMA4 protein network | https://string-db.org/network/9606.ENSP00000044462 | Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| ZPBP protein network | https://string-db.org/network/9606.ENSP00000046087 | Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization (By similarity); Immunoglobulin like [...] |
| LCP2 protein network | https://string-db.org/network/9606.ENSP00000046794 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling; SH2 domain containing |
| DCN protein network | https://string-db.org/network/9606.ENSP00000052754 | Decorin; May affect the rate of fibrils formation; Small leucine rich repeat proteoglycans |
| TNFRSF17 protein network | https://string-db.org/network/9606.ENSP00000053243 | Tumor necrosis factor receptor superfamily member 17; Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates [...] |
| MRPS10 protein network | https://string-db.org/network/9606.ENSP00000053468 | Mitochondrial ribosomal protein S10; Belongs to the universal ribosomal protein uS10 family |
| GRN protein network | https://string-db.org/network/9606.ENSP00000053867 | Granulins; Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling |
| THAP3 protein network | https://string-db.org/network/9606.ENSP00000054650 | THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1; THAP domain containing |
| VAMP3 protein network | https://string-db.org/network/9606.ENSP00000054666 | Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family |
| UTS2 protein network | https://string-db.org/network/9606.ENSP00000054668 | Urotensin 2; Endogenous ligands |
| RCN1 protein network | https://string-db.org/network/9606.ENSP00000054950 | Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; EF-hand domain containing |
| RFC2 protein network | https://string-db.org/network/9606.ENSP00000055077 | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...] |
| PPP1R3F protein network | https://string-db.org/network/9606.ENSP00000055335 | Protein phosphatase 1 regulatory subunit 3F; Glycogen-targeting subunit for protein phosphatase 1 (PP1) |
| KIAA2022 protein network | https://string-db.org/network/9606.ENSP00000055682 | Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding gen [...] |
| ARHGEF5 protein network | https://string-db.org/network/9606.ENSP00000056217 | Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and [...] |
| NFE2L3 protein network | https://string-db.org/network/9606.ENSP00000056233 | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins |
| TLL1 protein network | https://string-db.org/network/9606.ENSP00000061240 | Tolloid-like protein 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, whic [...] |
| NNAT protein network | https://string-db.org/network/9606.ENSP00000062104 | Neuronatin; May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system. May fu [...] |
| CBLN4 protein network | https://string-db.org/network/9606.ENSP00000064571 | Cerebellin-4; May be involved in synaptic functions in the CNS. May play a role in CBLN3 export from the endoplasmic reticulum and secretion (By similarity) |
| CLDN11 protein network | https://string-db.org/network/9606.ENSP00000064724 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| FAM168A protein network | https://string-db.org/network/9606.ENSP00000064778 | Protein FAM168A; In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decre [...] |
| RELT protein network | https://string-db.org/network/9606.ENSP00000064780 | Tumor necrosis factor receptor superfamily member 19L; Mediates activation of NF-kappa-B. May play a role in T- cell activation; RELT family |
| PKP2 protein network | https://string-db.org/network/9606.ENSP00000070846 | Plakophilin-2; May play a role in junctional plaques; Armadillo repeat containing |
| YIPF1 protein network | https://string-db.org/network/9606.ENSP00000072644 | Protein YIPF1; Yip1 domain family member 1; Belongs to the YIP1 family |
| ADCK2 protein network | https://string-db.org/network/9606.ENSP00000072869 | Uncharacterized aarF domain-containing protein kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosp [...] |
| INPP4A protein network | https://string-db.org/network/9606.ENSP00000074304 | Type I inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 3,4-bisph [...] |
| SLC2A3 protein network | https://string-db.org/network/9606.ENSP00000075120 | Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Med [...] |
| STYK1 protein network | https://string-db.org/network/9606.ENSP00000075503 | Tyrosine-protein kinase STYK1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion [...] |
| GNA11 protein network | https://string-db.org/network/9606.ENSP00000078429 | Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as [...] |
| CREB3L3 protein network | https://string-db.org/network/9606.ENSP00000078445 | Cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activat [...] |
| HDAC7 protein network | https://string-db.org/network/9606.ENSP00000080059 | Histone deacetylase 7; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| MRPS35 protein network | https://string-db.org/network/9606.ENSP00000081029 | Mitochondrial ribosomal protein S35 |
| APPBP2 protein network | https://string-db.org/network/9606.ENSP00000083182 | Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface |
| CA11 protein network | https://string-db.org/network/9606.ENSP00000084798 | Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Carbonic anhydrases |
| ISOC2 protein network | https://string-db.org/network/9606.ENSP00000085068 | Isochorismatase domain containing 2 |
| CD22 protein network | https://string-db.org/network/9606.ENSP00000085219 | B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially [...] |
| GSC2 protein network | https://string-db.org/network/9606.ENSP00000086933 | Homeobox protein goosecoid-2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC; Belongs to the paired homeobox family. Bicoid subf [...] |
| KCNQ1 protein network | https://string-db.org/network/9606.ENSP00000155840 | Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Assoc [...] |
| TRPM5 protein network | https://string-db.org/network/9606.ENSP00000155858 | Transient receptor potential cation channel subfamily M member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays [...] |
| TRIB2 protein network | https://string-db.org/network/9606.ENSP00000155926 | Tribbles homolog 2; Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr [...] |
| OTUD5 protein network | https://string-db.org/network/9606.ENSP00000156084 | OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I int [...] |
| GPKOW protein network | https://string-db.org/network/9606.ENSP00000156109 | RNA-binding protein involved in pre-mRNA splicing. |
| AQR protein network | https://string-db.org/network/9606.ENSP00000156471 | Intron-binding protein aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dep [...] |
| ST6GALNAC1 protein network | https://string-db.org/network/9606.ENSP00000156626 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Sialyltransferases |
| LMCD1 protein network | https://string-db.org/network/9606.ENSP00000157600 | LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstrea [...] |
| PSMC4 protein network | https://string-db.org/network/9606.ENSP00000157812 | 26S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| CAMKK1 protein network | https://string-db.org/network/9606.ENSP00000158166 | Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular p [...] |
| ACAP1 protein network | https://string-db.org/network/9606.ENSP00000158762 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins fr [...] |
| DERL2 protein network | https://string-db.org/network/9606.ENSP00000158771 | Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel [...] |
| NOX3 protein network | https://string-db.org/network/9606.ENSP00000159060 | NADPH oxidase 3; NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline st [...] |
| ANO8 protein network | https://string-db.org/network/9606.ENSP00000159087 | Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins |
| KDM4B protein network | https://string-db.org/network/9606.ENSP00000159111 | Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys [...] |
| ICAM3 protein network | https://string-db.org/network/9606.ENSP00000160262 | Intercellular adhesion molecule 3; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association [...] |
| CTTNBP2 protein network | https://string-db.org/network/9606.ENSP00000160373 | Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance; Ankyrin rep [...] |
| ACTL6B protein network | https://string-db.org/network/9606.ENSP00000160382 | Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remode [...] |
| KIF22 protein network | https://string-db.org/network/9606.ENSP00000160827 | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarit [...] |
| PRSS22 protein network | https://string-db.org/network/9606.ENSP00000161006 | Brain-specific serine protease 4; Preferentially cleaves the synthetic substrate H-D-Leu- Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA; Serine proteases |
| CEACAM1 protein network | https://string-db.org/network/9606.ENSP00000161559 | Carcinoembryonic antigen-related cell adhesion molecule 1; Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as [...] |
| YTHDC2 protein network | https://string-db.org/network/9606.ENSP00000161863 | Probable ATP-dependent RNA helicase YTHDC2; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs affecting the translation efficiency and mRNA abundance of its targets. Is r [...] |
| TMEM161A protein network | https://string-db.org/network/9606.ENSP00000162044 | Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis; Belongs to the TMEM161 fami [...] |
| FOXJ2 protein network | https://string-db.org/network/9606.ENSP00000162391 | Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S; Forkhead boxes |
| TNFRSF1A protein network | https://string-db.org/network/9606.ENSP00000162749 | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated recept [...] |
| GOLGA5 protein network | https://string-db.org/network/9606.ENSP00000163416 | Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport |
| CELSR3 protein network | https://string-db.org/network/9606.ENSP00000164024 | Cadherin EGF LAG seven-pass G-type receptor 3; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. [...] |
| PPP2R5B protein network | https://string-db.org/network/9606.ENSP00000164133 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine- protein phosphatase 2A (PP2A) holoenzyme, modulates substrate [...] |
| PYGM protein network | https://string-db.org/network/9606.ENSP00000164139 | Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their [...] |
| BCL3 protein network | https://string-db.org/network/9606.ENSP00000164227 | B-cell lymphoma 3 protein; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subun [...] |
| PIGB protein network | https://string-db.org/network/9606.ENSP00000164305 | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assemb [...] |
| PDZD4 protein network | https://string-db.org/network/9606.ENSP00000164640 | PDZ domain containing 4 |
| PRLH protein network | https://string-db.org/network/9606.ENSP00000165524 | Prolactin-releasing peptide; Stimulates prolactin (PRL) release and regulates the expression of prolactin through its receptor GPR10. May stimulate lactotrophs directly to secrete PRL; Endogenous [...] |
| FSTL3 protein network | https://string-db.org/network/9606.ENSP00000166139 | Follistatin-related protein 3; Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activi [...] |
| EPHA8 protein network | https://string-db.org/network/9606.ENSP00000166244 | Ephrin type-A receptor 8; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| TRIP13 protein network | https://string-db.org/network/9606.ENSP00000166345 | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that lea [...] |
| VASH1 protein network | https://string-db.org/network/9606.ENSP00000167106 | Vasohibin-1; Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells [...] |
| KRT14 protein network | https://string-db.org/network/9606.ENSP00000167586 | Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in re [...] |
| KRT20 protein network | https://string-db.org/network/9606.ENSP00000167588 | Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the [...] |
| SPP2 protein network | https://string-db.org/network/9606.ENSP00000168148 | Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover |
| HSD17B10 protein network | https://string-db.org/network/9606.ENSP00000168216 | 3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta- oxidation at position 17 of androgens and estrogens and has 3- alpha-hydroxysteroid dehydrogenase acti [...] |
| FGF4 protein network | https://string-db.org/network/9606.ENSP00000168712 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve developmen [...] |
| ST6GAL1 protein network | https://string-db.org/network/9606.ENSP00000169298 | Beta-galactoside alpha-2,6-sialyltransferase 1; Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates; Sialyltransferases |
| TIMM21 protein network | https://string-db.org/network/9606.ENSP00000169551 | Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for [...] |
| BPIFB2 protein network | https://string-db.org/network/9606.ENSP00000170150 | BPI fold containing family B member 2; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
| REXO1 protein network | https://string-db.org/network/9606.ENSP00000170168 | RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro; Belongs to the REXO1/REXO3 family |
| MKRN2 protein network | https://string-db.org/network/9606.ENSP00000170447 | Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Ring finger proteins |
| GPATCH1 protein network | https://string-db.org/network/9606.ENSP00000170564 | G-patch domain containing 1; Belongs to the GPATCH1 family |
| KEAP1 protein network | https://string-db.org/network/9606.ENSP00000171111 | Kelch-like ECH-associated protein 1; Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by [...] |
| P2RY10 protein network | https://string-db.org/network/9606.ENSP00000171757 | Putative P2Y purinoceptor 10; Putative receptor for purines coupled to G-proteins |
| TNS1 protein network | https://string-db.org/network/9606.ENSP00000171887 | Tensin-1; Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton; C2 tensin-type domain [...] |
| NGFR protein network | https://string-db.org/network/9606.ENSP00000172229 | Tumor necrosis factor receptor superfamily member 16; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insul [...] |
| NTN1 protein network | https://string-db.org/network/9606.ENSP00000173229 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectiv [...] |
| ISOC1 protein network | https://string-db.org/network/9606.ENSP00000173527 | Isochorismatase domain containing 1 |
| TRO protein network | https://string-db.org/network/9606.ENSP00000173898 | Trophinin; Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo [...] |
| MNT protein network | https://string-db.org/network/9606.ENSP00000174618 | Max-binding protein MNT; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'; Basic heli [...] |
| LAPTM4A protein network | https://string-db.org/network/9606.ENSP00000175091 | Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound comp [...] |
| ADAM7 protein network | https://string-db.org/network/9606.ENSP00000175238 | Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metallo [...] |
| ASNS protein network | https://string-db.org/network/9606.ENSP00000175506 | Asparagine synthetase |
| PTPN18 protein network | https://string-db.org/network/9606.ENSP00000175756 | Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues; Protein tyrosine phosph [...] |
| DRD4 protein network | https://string-db.org/network/9606.ENSP00000176183 | Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family |
| SCT protein network | https://string-db.org/network/9606.ENSP00000176195 | Secretin; Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach; Endogenous ligands |
| STK10 protein network | https://string-db.org/network/9606.ENSP00000176763 | Serine/threonine-protein kinase 10; Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte mig [...] |
| TBX21 protein network | https://string-db.org/network/9606.ENSP00000177694 | T-box transcription factor TBX21; Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repres [...] |
| MRPS34 protein network | https://string-db.org/network/9606.ENSP00000177742 | 28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for m [...] |
| CA12 protein network | https://string-db.org/network/9606.ENSP00000178638 | Carbonic anhydrase 12; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family |
| MAP2K5 protein network | https://string-db.org/network/9606.ENSP00000178640 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to p [...] |
| C12orf5 protein network | https://string-db.org/network/9606.ENSP00000179259 | Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intr [...] |
| FGF20 protein network | https://string-db.org/network/9606.ENSP00000180166 | Fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function |
| MTMR7 protein network | https://string-db.org/network/9606.ENSP00000180173 | Myotubularin-related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup; Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily |
| CPB2 protein network | https://string-db.org/network/9606.ENSP00000181383 | Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down [...] |
| FAM107B protein network | https://string-db.org/network/9606.ENSP00000181796 | Protein FAM107B; Family with sequence similarity 107 member B |
| CDK13 protein network | https://string-db.org/network/9606.ENSP00000181839 | Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptid [...] |
| TSPAN32 protein network | https://string-db.org/network/9606.ENSP00000182290 | Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family |
| TRAM2 protein network | https://string-db.org/network/9606.ENSP00000182527 | Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This couplin [...] |
| CLDN18 protein network | https://string-db.org/network/9606.ENSP00000183605 | Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family |
| ROPN1 protein network | https://string-db.org/network/9606.ENSP00000184183 | Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capaci [...] |
| NDUFB4 protein network | https://string-db.org/network/9606.ENSP00000184266 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| HEATR6 protein network | https://string-db.org/network/9606.ENSP00000184956 | HEAT repeat-containing protein 6; Amplification-dependent oncogene; Armadillo-like helical domain containing |
| ERLEC1 protein network | https://string-db.org/network/9606.ENSP00000185150 | Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-assoc [...] |
| CLIC5 protein network | https://string-db.org/network/9606.ENSP00000185206 | Chloride intracellular channel protein 5; Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarit [...] |
| TMEM131 protein network | https://string-db.org/network/9606.ENSP00000186436 | Transmembrane protein 131; May play a role in the immune response to viral infection |
| TMEM38A protein network | https://string-db.org/network/9606.ENSP00000187762 | Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions [...] |
| ACTR6 protein network | https://string-db.org/network/9606.ENSP00000188312 | ARP6 actin related protein 6 homolog; Belongs to the actin family. ARP6 subfamily |
| FAP protein network | https://string-db.org/network/9606.ENSP00000188790 | Prolyl endopeptidase FAP; Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibr [...] |
| DMRT3 protein network | https://string-db.org/network/9606.ENSP00000190165 | Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal spe [...] |
| GAL3ST2 protein network | https://string-db.org/network/9606.ENSP00000192314 | Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal- beta-1,3-GlcNAc) and type 2 (Gal-beta-1 [...] |
| UHRF1BP1 protein network | https://string-db.org/network/9606.ENSP00000192788 | UHRF1-binding protein 1; May act as a negative regulator of cell growth |
| OSTM1 protein network | https://string-db.org/network/9606.ENSP00000193322 | Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function |
| IMPG2 protein network | https://string-db.org/network/9606.ENSP00000193391 | Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and [...] |
| SLC13A1 protein network | https://string-db.org/network/9606.ENSP00000194130 | Solute carrier family 13 member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily |
| PCDHB4 protein network | https://string-db.org/network/9606.ENSP00000194152 | Protocadherin beta-4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| PCDHB2 protein network | https://string-db.org/network/9606.ENSP00000194155 | Protocadherin beta-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| HSPB11 protein network | https://string-db.org/network/9606.ENSP00000194214 | Intraflagellar transport protein 25 homolog; Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and [...] |
| STRADB protein network | https://string-db.org/network/9606.ENSP00000194530 | STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typ [...] |
| C4orf6 protein network | https://string-db.org/network/9606.ENSP00000195455 | Uncharacterized protein encoded by LINC01587; Chromosome 4 open reading frame 6 |
| PLOD1 protein network | https://string-db.org/network/9606.ENSP00000196061 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for [...] |
| OXCT1 protein network | https://string-db.org/network/9606.ENSP00000196371 | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA interm [...] |
| ZNF416 protein network | https://string-db.org/network/9606.ENSP00000196489 | Zinc finger protein 416; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| KIAA1467 protein network | https://string-db.org/network/9606.ENSP00000197268 | Protein FAM234B; KIAA1467 |
| PILRA protein network | https://string-db.org/network/9606.ENSP00000198536 | Paired immunoglobulin-like type 2 receptor alpha; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PI [...] |
| RRN3 protein network | https://string-db.org/network/9606.ENSP00000198767 | RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation comp [...] |
| MOGAT2 protein network | https://string-db.org/network/9606.ENSP00000198801 | 2-acylglycerol O-acyltransferase 2; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty a [...] |
| AQP2 protein network | https://string-db.org/network/9606.ENSP00000199280 | Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an os [...] |
| DIMT1 protein network | https://string-db.org/network/9606.ENSP00000199320 | Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-r [...] |
| EIF2AK1 protein network | https://string-db.org/network/9606.ENSP00000199389 | Eukaryotic translation initiation factor 2-alpha kinase 1; Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, he [...] |
| NME8 protein network | https://string-db.org/network/9606.ENSP00000199447 | Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (F [...] |
| EPDR1 protein network | https://string-db.org/network/9606.ENSP00000199448 | Mammalian ependymin-related protein 1; Ependymin related 1 |
| MRPL28 protein network | https://string-db.org/network/9606.ENSP00000199706 | Mitochondrial ribosomal protein L28 |
| HBQ1 protein network | https://string-db.org/network/9606.ENSP00000199708 | Hemoglobin subunit theta 1 |
| CEACAM6 protein network | https://string-db.org/network/9606.ENSP00000199764 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| RBM22 protein network | https://string-db.org/network/9606.ENSP00000199814 | Pre-mRNA-splicing factor RBM22; Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splic [...] |
| HSD17B2 protein network | https://string-db.org/network/9606.ENSP00000199936 | Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while [...] |
| ZW10 protein network | https://string-db.org/network/9606.ENSP00000200135 | Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin [...] |
| ITGB4 protein network | https://string-db.org/network/9606.ENSP00000200181 | Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polar [...] |
| PPP1R15A protein network | https://string-db.org/network/9606.ENSP00000200453 | Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut- [...] |
| TRIP6 protein network | https://string-db.org/network/9606.ENSP00000200457 | Thyroid receptor-interacting protein 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involv [...] |
| ADAM11 protein network | https://string-db.org/network/9606.ENSP00000200557 | Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein; ADAM metallopeptidase domain conta [...] |
| SLC22A4 protein network | https://string-db.org/network/9606.ENSP00000200652 | Solute carrier family 22 member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations suc [...] |
| CETP protein network | https://string-db.org/network/9606.ENSP00000200676 | Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl e [...] |
| MT3 protein network | https://string-db.org/network/9606.ENSP00000200691 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortica [...] |
| TFAP2C protein network | https://string-db.org/network/9606.ENSP00000201031 | Transcription factor AP-2 gamma; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...] |
| SULT2B1 protein network | https://string-db.org/network/9606.ENSP00000201586 | Sulfotransferase family cytosolic 2B member 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurot [...] |
| EPS8L1 protein network | https://string-db.org/network/9606.ENSP00000201647 | Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton; Be [...] |
| REM1 protein network | https://string-db.org/network/9606.ENSP00000201979 | GTP-binding protein REM 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling; RGK type GTPase family |
| PDRG1 protein network | https://string-db.org/network/9606.ENSP00000202017 | P53 and DNA damage-regulated protein 1; May play a role in chaperone-mediated protein folding; Belongs to the prefoldin subunit beta family |
| PPP1R13B protein network | https://string-db.org/network/9606.ENSP00000202556 | Apoptosis-stimulating of p53 protein 1; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transacti [...] |
| TGM6 protein network | https://string-db.org/network/9606.ENSP00000202625 | Protein-glutamine gamma-glutamyltransferase 6; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase [...] |
| RALGAPA2 protein network | https://string-db.org/network/9606.ENSP00000202677 | Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB; Armadillo-like [...] |
| ESF1 protein network | https://string-db.org/network/9606.ENSP00000202816 | ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity) |
| SIRT4 protein network | https://string-db.org/network/9606.ENSP00000202967 | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and b [...] |
| TRMT6 protein network | https://string-db.org/network/9606.ENSP00000203001 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at [...] |
| UQCRC1 protein network | https://string-db.org/network/9606.ENSP00000203407 | Cytochrome b-c1 complex subunit 1, mitochondrial; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial [...] |
| GMIP protein network | https://string-db.org/network/9606.ENSP00000203556 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA |
| LAG3 protein network | https://string-db.org/network/9606.ENSP00000203629 | Lymphocyte activation gene 3 protein; Involved in lymphocyte activation. Binds to HLA class-II antigens; CD molecules |
| MLF2 protein network | https://string-db.org/network/9606.ENSP00000203630 | Myeloid leukemia factor 2 |
| OTUB2 protein network | https://string-db.org/network/9606.ENSP00000203664 | Ubiquitin thioesterase OTUB2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by prevent [...] |
| TFAP4 protein network | https://string-db.org/network/9606.ENSP00000204517 | Transcription factor AP-4; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'; Basic helix-loop-helix proteins |
| PDCD7 protein network | https://string-db.org/network/9606.ENSP00000204549 | Programmed cell death protein 7; Promotes apoptosis when overexpressed; U11/U12 di-snRNP |
| SPG21 protein network | https://string-db.org/network/9606.ENSP00000204566 | Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation |
| CHRD protein network | https://string-db.org/network/9606.ENSP00000204604 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequest [...] |
| THPO protein network | https://string-db.org/network/9606.ENSP00000204615 | Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. [...] |
| GNPTG protein network | https://string-db.org/network/9606.ENSP00000204679 | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phospha [...] |
| GOLGA3 protein network | https://string-db.org/network/9606.ENSP00000204726 | Golgin subfamily A member 3; Golgi auto-antigen; probably involved in maintaining Golgi structure |
| EFNB1 protein network | https://string-db.org/network/9606.ENSP00000204961 | Ephrin-B1; Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation o [...] |
| GLG1 protein network | https://string-db.org/network/9606.ENSP00000205061 | Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell- adhesion lectin on endothelial cells mediating the binding of neutrophils) |
| DLL3 protein network | https://string-db.org/network/9606.ENSP00000205143 | Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmenta [...] |
| NAT14 protein network | https://string-db.org/network/9606.ENSP00000205194 | N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG- 3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro [...] |
| AASDH protein network | https://string-db.org/network/9606.ENSP00000205214 | Acyl-CoA synthetase family member 4; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA; Acyl-CoA synthetase family |
| DLD protein network | https://string-db.org/network/9606.ENSP00000205402 | Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruv [...] |
| ABCC6 protein network | https://string-db.org/network/9606.ENSP00000205557 | Multidrug resistance-associated protein 6; Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports g [...] |
| CMTM6 protein network | https://string-db.org/network/9606.ENSP00000205636 | CKLF like MARVEL transmembrane domain containing 6; Belongs to the chemokine-like factor family |
| MYO15A protein network | https://string-db.org/network/9606.ENSP00000205890 | Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| APOH protein network | https://string-db.org/network/9606.ENSP00000205948 | Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation casca [...] |
| SPAG7 protein network | https://string-db.org/network/9606.ENSP00000206020 | Sperm associated antigen 7 |
| CCDC80 protein network | https://string-db.org/network/9606.ENSP00000206423 | Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly |
| HAUS4 protein network | https://string-db.org/network/9606.ENSP00000206474 | HAUS augmin-like complex subunit 4; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| CEBPE protein network | https://string-db.org/network/9606.ENSP00000206513 | CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced [...] |
| OSGEP protein network | https://string-db.org/network/9606.ENSP00000206542 | Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) i [...] |
| G2E3 protein network | https://string-db.org/network/9606.ENSP00000206595 | G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers [...] |
| TGM1 protein network | https://string-db.org/network/9606.ENSP00000206765 | Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross- linking epidermal proteins during form [...] |
| TBX15 protein network | https://string-db.org/network/9606.ENSP00000207157 | T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchy [...] |
| TEKT2 protein network | https://string-db.org/network/9606.ENSP00000207457 | Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. [...] |
| UNC13D protein network | https://string-db.org/network/9606.ENSP00000207549 | Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates a [...] |
| XYLB protein network | https://string-db.org/network/9606.ENSP00000207870 | Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5- phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis |
| OR1I1 protein network | https://string-db.org/network/9606.ENSP00000209540 | Olfactory receptor 1I1; Odorant receptor; Olfactory receptors, family 1 |
| ADH1A protein network | https://string-db.org/network/9606.ENSP00000209668 | Alcohol dehydrogenase 1A, alpha polypeptide; Belongs to the zinc-containing alcohol dehydrogenase family |
| KRT23 protein network | https://string-db.org/network/9606.ENSP00000209718 | Keratin, type I cytoskeletal 23; Keratins, type I |
| CDC6 protein network | https://string-db.org/network/9606.ENSP00000209728 | Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiat [...] |
| AAAS protein network | https://string-db.org/network/9606.ENSP00000209873 | Aladin; Plays a role in the normal development of the peripheral and central nervous system; Nucleoporins |
| CBX5 protein network | https://string-db.org/network/9606.ENSP00000209875 | Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded [...] |
| KLHL20 protein network | https://string-db.org/network/9606.ENSP00000209884 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR [...] |
| FMO2 protein network | https://string-db.org/network/9606.ENSP00000209929 | Dimethylaniline monooxygenase [N-oxide-forming] 2; Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary a [...] |
| DHPS protein network | https://string-db.org/network/9606.ENSP00000210060 | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific ly [...] |
| RAB26 protein network | https://string-db.org/network/9606.ENSP00000210187 | Ras-related protein Rab-26; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| PSMD5 protein network | https://string-db.org/network/9606.ENSP00000210313 | 26S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the [...] |
| NANS protein network | https://string-db.org/network/9606.ENSP00000210444 | Sialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate a [...] |
| SEMA4G protein network | https://string-db.org/network/9606.ENSP00000210633 | Semaphorin-4G; Cell surface receptor for PLXNB2. May play a role in axon guidance (By similarity); Immunoglobulin like domain containing |
| TPSD1 protein network | https://string-db.org/network/9606.ENSP00000211076 | Tryptase delta; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 fami [...] |
| GSTA3 protein network | https://string-db.org/network/9606.ENSP00000211122 | Glutathione S-transferase A3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the b [...] |
| MAPK13 protein network | https://string-db.org/network/9606.ENSP00000211287 | Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an [...] |
| TMEM14A protein network | https://string-db.org/network/9606.ENSP00000211314 | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family |
| PRRT1 protein network | https://string-db.org/network/9606.ENSP00000211413 | Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family |
| ZNF184 protein network | https://string-db.org/network/9606.ENSP00000211936 | Zinc finger protein 184; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| VCL protein network | https://string-db.org/network/9606.ENSP00000211998 | Vinculin; Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-c [...] |
| SIRT1 protein network | https://string-db.org/network/9606.ENSP00000212015 | NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of s [...] |
| TGFBR3 protein network | https://string-db.org/network/9606.ENSP00000212355 | Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors; Proteoglycans |
| TMED1 protein network | https://string-db.org/network/9606.ENSP00000214869 | Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorp [...] |
| MZF1 protein network | https://string-db.org/network/9606.ENSP00000215057 | Myeloid zinc finger 1; Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional eve [...] |
| OCEL1 protein network | https://string-db.org/network/9606.ENSP00000215061 | occludin/ELL domain containing 1; Belongs to the ELL/occludin family |
| PSMD8 protein network | https://string-db.org/network/9606.ENSP00000215071 | 26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| STX1B protein network | https://string-db.org/network/9606.ENSP00000215095 | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity); Belongs to [...] |
| EFNA2 protein network | https://string-db.org/network/9606.ENSP00000215368 | Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...] |
| ATP5D protein network | https://string-db.org/network/9606.ENSP00000215375 | ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...] |
| FGF22 protein network | https://string-db.org/network/9606.ENSP00000215530 | Fibroblast growth factor 22; Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development |
| SMIM24 protein network | https://string-db.org/network/9606.ENSP00000215531 | Small integral membrane protein 24 |
| NDUFB7 protein network | https://string-db.org/network/9606.ENSP00000215565 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| TECR protein network | https://string-db.org/network/9606.ENSP00000215567 | Very-long-chain enoyl-CoA reductase; Catalyzes the last of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addi [...] |
| TIMM13 protein network | https://string-db.org/network/9606.ENSP00000215570 | Mitochondrial import inner membrane translocase subunit Tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into t [...] |
| CDC34 protein network | https://string-db.org/network/9606.ENSP00000215574 | Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Cooperat [...] |
| MISP protein network | https://string-db.org/network/9606.ENSP00000215582 | Mitotic interactor and substrate of PLK1; Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner [...] |
| GADD45B protein network | https://string-db.org/network/9606.ENSP00000215631 | Growth arrest and DNA damage-inducible protein GADD45 beta; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK |
| MADCAM1 protein network | https://string-db.org/network/9606.ENSP00000215637 | Mucosal addressin cell adhesion molecule 1; Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and [...] |
| MAPK12 protein network | https://string-db.org/network/9606.ENSP00000215659 | Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an [...] |
| SERPIND1 protein network | https://string-db.org/network/9606.ENSP00000215727 | Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place o [...] |
| SNAP29 protein network | https://string-db.org/network/9606.ENSP00000215730 | Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on o [...] |
| LZTR1 protein network | https://string-db.org/network/9606.ENSP00000215739 | Leucine-zipper-like transcriptional regulator 1; Probable transcriptional regulator that may play a crucial role in embryogenesis; BTB domain containing |
| THAP7 protein network | https://string-db.org/network/9606.ENSP00000215742 | THAP domain-containing protein 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors; THAP domain c [...] |
| MMP11 protein network | https://string-db.org/network/9606.ENSP00000215743 | Stromelysin-3; May play an important role in the progression of epithelial malignancies; M10 matrix metallopeptidases |
| MIF protein network | https://string-db.org/network/9606.ENSP00000215754 | Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as [...] |
| DDTL protein network | https://string-db.org/network/9606.ENSP00000215770 | D-dopachrome decarboxylase-like protein; May have lyase activity |
| OSM protein network | https://string-db.org/network/9606.ENSP00000215781 | Oncostatin-M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and [...] |
| SF3A1 protein network | https://string-db.org/network/9606.ENSP00000215793 | Splicing factor 3A subunit 1; Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequenc [...] |
| USP18 protein network | https://string-db.org/network/9606.ENSP00000215794 | Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked vi [...] |
| SEC14L3 protein network | https://string-db.org/network/9606.ENSP00000215812 | SEC14-like protein 3; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids; SEC14 family |
| SNRPD3 protein network | https://string-db.org/network/9606.ENSP00000215829 | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an im [...] |
| MAPK1 protein network | https://string-db.org/network/9606.ENSP00000215832 | Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which pla [...] |
| TCN2 protein network | https://string-db.org/network/9606.ENSP00000215838 | Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells; Belongs to the eukaryotic cobalamin transport proteins family |
| CRYBB3 protein network | https://string-db.org/network/9606.ENSP00000215855 | Beta-crystallin B3; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| MORC2 protein network | https://string-db.org/network/9606.ENSP00000215862 | MORC family CW-type zinc finger protein 2; Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing [...] |
| SLC25A1 protein network | https://string-db.org/network/9606.ENSP00000215882 | Tricarboxylate transport protein, mitochondrial; Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and stero [...] |
| PLA2G3 protein network | https://string-db.org/network/9606.ENSP00000215885 | Group 3 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosp [...] |
| LGALS2 protein network | https://string-db.org/network/9606.ENSP00000215886 | Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known; Galectins |
| PDXP protein network | https://string-db.org/network/9606.ENSP00000215904 | Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependen [...] |
| ASPHD2 protein network | https://string-db.org/network/9606.ENSP00000215906 | Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase |
| LGALS1 protein network | https://string-db.org/network/9606.ENSP00000215909 | Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein [...] |
| PIK3IP1 protein network | https://string-db.org/network/9606.ENSP00000215912 | Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity |
| SRRD protein network | https://string-db.org/network/9606.ENSP00000215917 | SRR1-like protein; May be involved in a circadian clock input pathway |
| CRYBB1 protein network | https://string-db.org/network/9606.ENSP00000215939 | Beta-crystallin B1; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| ANKRD54 protein network | https://string-db.org/network/9606.ENSP00000215941 | Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation; Ankyrin repeat domain contain [...] |
| MICALL1 protein network | https://string-db.org/network/9606.ENSP00000215957 | MICAL-like protein 1; Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream e [...] |
| CENPM protein network | https://string-db.org/network/9606.ENSP00000215980 | Centromere protein M; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| DMC1 protein network | https://string-db.org/network/9606.ENSP00000216024 | Meiotic recombination protein DMC1/LIM15 homolog; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double- [...] |
| HSCB protein network | https://string-db.org/network/9606.ENSP00000216027 | Iron-sulfur cluster co-chaperone protein HscB, mitochondrial; Acts as a co-chaperone in iron-sulfur cluster assembly in mitochondria; Belongs to the HscB family |
| TOMM22 protein network | https://string-db.org/network/9606.ENSP00000216034 | Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and transloc [...] |
| RTDR1 protein network | https://string-db.org/network/9606.ENSP00000216036 | Radial spoke head 14 homolog; Rhabdoid tumor deletion region gene 1; Belongs to the flagellar radial spoke RSP14 family |
| XBP1 protein network | https://string-db.org/network/9606.ENSP00000216037 | X-box-binding protein 1; Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepato [...] |
| RTCB protein network | https://string-db.org/network/9606.ENSP00000216038 | tRNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-der [...] |
| JOSD1 protein network | https://string-db.org/network/9606.ENSP00000216039 | Josephin-1; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinat [...] |
| GTPBP1 protein network | https://string-db.org/network/9606.ENSP00000216044 | GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) |
| DNAL4 protein network | https://string-db.org/network/9606.ENSP00000216068 | Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity); Dyneins, axonemal |
| C22orf31 protein network | https://string-db.org/network/9606.ENSP00000216071 | Uncharacterized protein C22orf31; Chromosome 22 open reading frame 31 |
| MIOX protein network | https://string-db.org/network/9606.ENSP00000216075 | Belongs to the myo-inositol oxygenase family. |
| RHBDD3 protein network | https://string-db.org/network/9606.ENSP00000216085 | Rhomboid domain containing 3 |
| APOBEC3D protein network | https://string-db.org/network/9606.ENSP00000216099 | DNA dC->dU-editing enzyme APOBEC-3D; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| RASL10A protein network | https://string-db.org/network/9606.ENSP00000216101 | Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family |
| HMGXB4 protein network | https://string-db.org/network/9606.ENSP00000216106 | HMG domain-containing protein 4; Negatively regulates Wnt/beta-catenin signaling during development; Non-canonical high mobility group |
| BIK protein network | https://string-db.org/network/9606.ENSP00000216115 | Bcl-2-interacting killer; Accelerates programmed cell death. Association to the apoptosis repressors Bcl-X(L), BHRF1, Bcl-2 or its adenovirus homolog E1B 19k protein suppresses this death-promoti [...] |
| HMOX1 protein network | https://string-db.org/network/9606.ENSP00000216117 | Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiologic [...] |
| NIPSNAP1 protein network | https://string-db.org/network/9606.ENSP00000216121 | Nipsnap homolog 1 |
| MCM5 protein network | https://string-db.org/network/9606.ENSP00000216122 | DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| ARSA protein network | https://string-db.org/network/9606.ENSP00000216124 | Arylsulfatase A; Hydrolyzes cerebroside sulfate; Belongs to the sulfatase family |
| RASD2 protein network | https://string-db.org/network/9606.ENSP00000216127 | GTP-binding protein Rhes; GTPase signaling protein that binds to and hydrolyzes GTP. Regulates signaling pathways involving G-proteins-coupled receptor and heterotrimeric proteins such as GNB1, G [...] |
| TTLL12 protein network | https://string-db.org/network/9606.ENSP00000216129 | Tubulin--tyrosine ligase-like protein 12; Tubulin tyrosine ligase like 12 |
| CBX7 protein network | https://string-db.org/network/9606.ENSP00000216133 | Chromobox protein homolog 7; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| ACR protein network | https://string-db.org/network/9606.ENSP00000216139 | Acrosin; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the ac [...] |
| CABP7 protein network | https://string-db.org/network/9606.ENSP00000216144 | Calcium-binding protein 7; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity; EF-hand domain containing |
| TAB1 protein network | https://string-db.org/network/9606.ENSP00000216160 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis |
| PNPLA5 protein network | https://string-db.org/network/9606.ENSP00000216177 | Patatin-like phospholipase domain-containing protein 5; Lipid hydrolase; Patatin like phospholipase domain containing |
| PNPLA3 protein network | https://string-db.org/network/9606.ENSP00000216180 | Patatin-like phospholipase domain-containing protein 3; Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities; Lipases |
| MYH9 protein network | https://string-db.org/network/9606.ENSP00000216181 | Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. During cell spreading, plays an important role in cytosk [...] |
| TXN2 protein network | https://string-db.org/network/9606.ENSP00000216185 | Thioredoxin, mitochondrial; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity; Belongs [...] |
| EIF3D protein network | https://string-db.org/network/9606.ENSP00000216190 | Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the ini [...] |
| PVALB protein network | https://string-db.org/network/9606.ENSP00000216200 | Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; EF-hand domain containing |
| UPK3A protein network | https://string-db.org/network/9606.ENSP00000216211 | Uroplakin-3a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoske [...] |
| FAM118A protein network | https://string-db.org/network/9606.ENSP00000216214 | Protein FAM118A; Family with sequence similarity 118 member A |
| ST13 protein network | https://string-db.org/network/9606.ENSP00000216218 | Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that h [...] |
| IL2RB protein network | https://string-db.org/network/9606.ENSP00000216223 | Interleukin-2 receptor subunit beta; Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2; Belongs to the type I [...] |
| RBX1 protein network | https://string-db.org/network/9606.ENSP00000216225 | E3 ubiquitin-protein ligase RBX1; E3 ubiquitin ligase component of multiple cullin-RING- based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteas [...] |
| L3MBTL2 protein network | https://string-db.org/network/9606.ENSP00000216237 | Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...] |
| CHADL protein network | https://string-db.org/network/9606.ENSP00000216241 | Chondroadherin-like protein; Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocyte's differentiation by acting on its [...] |
| PHF5A protein network | https://string-db.org/network/9606.ENSP00000216252 | PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryo [...] |
| ACO2 protein network | https://string-db.org/network/9606.ENSP00000216254 | Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis-aconitate; Belongs to the aconitase/IPM isomerase family |
| PMM1 protein network | https://string-db.org/network/9606.ENSP00000216259 | Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible fo [...] |
| CERK protein network | https://string-db.org/network/9606.ENSP00000216264 | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydrocerami [...] |
| BRD1 protein network | https://string-db.org/network/9606.ENSP00000216267 | Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity; Bromodomain containing |
| ZBED4 protein network | https://string-db.org/network/9606.ENSP00000216268 | Zinc finger BED-type containing 4 |
| HDAC10 protein network | https://string-db.org/network/9606.ENSP00000216271 | Histone deacetylase 10; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic re [...] |
| RIPK3 protein network | https://string-db.org/network/9606.ENSP00000216274 | Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necros [...] |
| PAPOLA protein network | https://string-db.org/network/9606.ENSP00000216277 | Poly(A) polymerase alpha; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity [...] |
| NID2 protein network | https://string-db.org/network/9606.ENSP00000216286 | Nidogen-2; Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role [...] |
| SNAPC1 protein network | https://string-db.org/network/9606.ENSP00000216294 | snRNA-activating protein complex subunit 1; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...] |
| SUPT16H protein network | https://string-db.org/network/9606.ENSP00000216297 | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a [...] |
| FKBP3 protein network | https://string-db.org/network/9606.ENSP00000216330 | Peptidyl-prolyl cis-trans isomerase FKBP3; FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arre [...] |
| CTSG protein network | https://string-db.org/network/9606.ENSP00000216336 | Cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial act [...] |
| GZMH protein network | https://string-db.org/network/9606.ENSP00000216338 | Granzyme H; Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for tar [...] |
| GZMB protein network | https://string-db.org/network/9606.ENSP00000216341 | Granzyme B; This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cy [...] |
| AP4S1 protein network | https://string-db.org/network/9606.ENSP00000216366 | AP-4 complex subunit sigma-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They [...] |
| POLE2 protein network | https://string-db.org/network/9606.ENSP00000216367 | DNA polymerase epsilon subunit 2; Participates in DNA repair and in chromosomal DNA replication |
| SOS2 protein network | https://string-db.org/network/9606.ENSP00000216373 | Son of sevenless homolog 2; Promotes the exchange of Ras-bound GDP by GTP; Pleckstrin homology domain containing |
| PYGL protein network | https://string-db.org/network/9606.ENSP00000216392 | Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their n [...] |
| GNPNAT1 protein network | https://string-db.org/network/9606.ENSP00000216410 | Glucosamine-phosphate N-acetyltransferase 1; Belongs to the acetyltransferase family. GNA1 subfamily |
| CNIH1 protein network | https://string-db.org/network/9606.ENSP00000216416 | Protein cornichon homolog 1; Involved in the selective transport and maturation of TGF-alpha family proteins; Belongs to the cornichon family |
| CGRRF1 protein network | https://string-db.org/network/9606.ENSP00000216420 | Cell growth regulator with RING finger domain protein 1; Able to inhibit growth in several cell lines; Ring finger proteins |
| ATP6V1D protein network | https://string-db.org/network/9606.ENSP00000216442 | V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, [...] |
| PLEK2 protein network | https://string-db.org/network/9606.ENSP00000216446 | Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation; Pleckstrin homology domain containing |
| PIGH protein network | https://string-db.org/network/9606.ENSP00000216452 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...] |
| PSMA3 protein network | https://string-db.org/network/9606.ENSP00000216455 | Proteasome subunit alpha type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| GSTZ1 protein network | https://string-db.org/network/9606.ENSP00000216465 | Maleylacetoacetate isomerase; Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomera [...] |
| TMED8 protein network | https://string-db.org/network/9606.ENSP00000216468 | Protein TMED8; Transmembrane p24 trafficking protein family member 8; GOLD domain containing |
| SAMD15 protein network | https://string-db.org/network/9606.ENSP00000216471 | Sterile alpha motif domain containing 15 |
| AHSA1 protein network | https://string-db.org/network/9606.ENSP00000216479 | Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with [...] |
| SPTLC2 protein network | https://string-db.org/network/9606.ENSP00000216484 | Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) [...] |
| RIN3 protein network | https://string-db.org/network/9606.ENSP00000216487 | Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function; [...] |
| ALKBH1 protein network | https://string-db.org/network/9606.ENSP00000216489 | Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been describ [...] |
| CHGA protein network | https://string-db.org/network/9606.ENSP00000216492 | Chromogranin-A; Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas; Belongs to the chromogranin/secretogranin protein family |
| DHRS7 protein network | https://string-db.org/network/9606.ENSP00000216500 | Dehydrogenase/reductase SDR family member 7; Short chain dehydrogenase/reductase superfamily |
| SIX4 protein network | https://string-db.org/network/9606.ENSP00000216513 | Homeobox protein SIX4; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like [...] |
| SLC10A1 protein network | https://string-db.org/network/9606.ENSP00000216540 | Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly depe [...] |
| EIF5 protein network | https://string-db.org/network/9606.ENSP00000216554 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S rib [...] |
| ZFYVE21 protein network | https://string-db.org/network/9606.ENSP00000216602 | Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtub [...] |
| MTHFD1 protein network | https://string-db.org/network/9606.ENSP00000216605 | C-1-tetrahydrofolate synthase, cytoplasmic; Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1; In the N-terminal section; belongs to the tetrahydrofo [...] |
| BDKRB1 protein network | https://string-db.org/network/9606.ENSP00000216629 | B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation |
| VRK1 protein network | https://string-db.org/network/9606.ENSP00000216639 | Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragm [...] |
| APEX1 protein network | https://string-db.org/network/9606.ENSP00000216714 | DNA-(apurinic or apyrimidinic site) lyase; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redo [...] |
| PABPN1 protein network | https://string-db.org/network/9606.ENSP00000216727 | Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product (By similarity). S [...] |
| EFS protein network | https://string-db.org/network/9606.ENSP00000216733 | Embryonal Fyn-associated substrate; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a do [...] |
| CINP protein network | https://string-db.org/network/9606.ENSP00000216756 | Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 [...] |
| PCK2 protein network | https://string-db.org/network/9606.ENSP00000216780 | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces [...] |
| NFKBIA protein network | https://string-db.org/network/9606.ENSP00000216797 | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular st [...] |
| PSME2 protein network | https://string-db.org/network/9606.ENSP00000216802 | Proteasome activator complex subunit 2; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I bindin [...] |
| BRMS1L protein network | https://string-db.org/network/9606.ENSP00000216807 | Breast cancer metastasis-suppressor 1-like protein; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lac [...] |
| PNN protein network | https://string-db.org/network/9606.ENSP00000216832 | Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription [...] |
| CYP24A1 protein network | https://string-db.org/network/9606.ENSP00000216862 | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25- hydroxyvitamin D(3)) and [...] |
| AURKA protein network | https://string-db.org/network/9606.ENSP00000216911 | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays [...] |
| ZFP64 protein network | https://string-db.org/network/9606.ENSP00000216923 | Zinc finger protein 64 homolog, isoforms 1 and 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| GSS protein network | https://string-db.org/network/9606.ENSP00000216951 | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family |
| PYGB protein network | https://string-db.org/network/9606.ENSP00000216962 | Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different [...] |
| PROCR protein network | https://string-db.org/network/9606.ENSP00000216968 | Endothelial protein C receptor; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulatio [...] |
| MYBL2 protein network | https://string-db.org/network/9606.ENSP00000217026 | Myb-related protein B; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene; Myb/SANT domain contain [...] |
| R3HDML protein network | https://string-db.org/network/9606.ENSP00000217043 | Peptidase inhibitor R3HDML; Putative serine protease inhibitor; CAP superfamily |
| SALL4 protein network | https://string-db.org/network/9606.ENSP00000217086 | Sal-like protein 4; Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells; Zinc fingers C2H2-type |
| CSTF1 protein network | https://string-db.org/network/9606.ENSP00000217109 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with oth [...] |
| TPD52L2 protein network | https://string-db.org/network/9606.ENSP00000217121 | Tumor protein D52 like 2 |
| CTSZ protein network | https://string-db.org/network/9606.ENSP00000217131 | Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy- dipeptidase activity; Cathepsins |
| TUBB1 protein network | https://string-db.org/network/9606.ENSP00000217133 | Tubulin beta-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...] |
| SLCO4A1 protein network | https://string-db.org/network/9606.ENSP00000217159 | Solute carrier organic anion transporter family member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT [...] |
| BIRC7 protein network | https://string-db.org/network/9606.ENSP00000217169 | Baculoviral IAP repeat-containing protein 7; Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell [...] |
| UBOX5 protein network | https://string-db.org/network/9606.ENSP00000217173 | RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substr [...] |
| EEF1A2 protein network | https://string-db.org/network/9606.ENSP00000217182 | Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation fact [...] |
| SRMS protein network | https://string-db.org/network/9606.ENSP00000217188 | Tyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. May be involved in proliferation or differentiation of keratinocytes in the skin [...] |
| C20orf27 protein network | https://string-db.org/network/9606.ENSP00000217195 | UPF0687 protein C20orf27; Chromosome 20 open reading frame 27 |
| TRIB3 protein network | https://string-db.org/network/9606.ENSP00000217233 | Tribbles homolog 3; Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to [...] |
| CSNK2A1 protein network | https://string-db.org/network/9606.ENSP00000217244 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C- [...] |
| MACROD2 protein network | https://string-db.org/network/9606.ENSP00000217246 | O-acetyl-ADP-ribose deacetylase MACROD2; Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates [...] |
| SLC52A3 protein network | https://string-db.org/network/9606.ENSP00000217254 | Solute carrier family 52, riboflavin transporter, member 3; Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption. Riboflavin transport is Na(+)- independent [...] |
| RSPO4 protein network | https://string-db.org/network/9606.ENSP00000217260 | R-spondin-4; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...] |
| PROKR2 protein network | https://string-db.org/network/9606.ENSP00000217270 | Prokineticin receptor 2; Receptor for prokineticin 2. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinosit [...] |
| FERMT1 protein network | https://string-db.org/network/9606.ENSP00000217289 | Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte prolifera [...] |
| TLDC2 protein network | https://string-db.org/network/9606.ENSP00000217320 | TLD domain-containing protein 2; TBC/LysM-associated domain containing 2; Belongs to the OXR1 family |
| CDK5RAP1 protein network | https://string-db.org/network/9606.ENSP00000217372 | CDK5 regulatory subunit-associated protein 1; Specifically inhibits CDK5 activation by CDK5R1 |
| SNTA1 protein network | https://string-db.org/network/9606.ENSP00000217381 | Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and t [...] |
| OXT protein network | https://string-db.org/network/9606.ENSP00000217386 | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin; Endogenous ligands |
| CHMP4B protein network | https://string-db.org/network/9606.ENSP00000217402 | Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| LBP protein network | https://string-db.org/network/9606.ENSP00000217407 | Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of a [...] |
| SLC32A1 protein network | https://string-db.org/network/9606.ENSP00000217420 | Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles; Solute carriers |
| CST4 protein network | https://string-db.org/network/9606.ENSP00000217423 | Cystatin-S; This protein strongly inhibits papain and ficin, partially inhibits stem bromelain and bovine cathepsin C, but does not inhibit porcine cathepsin B or clostripain. Papain is inhibited [...] |
| AHCY protein network | https://string-db.org/network/9606.ENSP00000217426 | Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in [...] |
| SPINT3 protein network | https://string-db.org/network/9606.ENSP00000217428 | Serine peptidase inhibitor, Kunitz type 3 |
| PIGU protein network | https://string-db.org/network/9606.ENSP00000217446 | Phosphatidylinositol glycan anchor biosynthesis class U protein; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid por [...] |
| ACOT8 protein network | https://string-db.org/network/9606.ENSP00000217455 | Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing [...] |
| APMAP protein network | https://string-db.org/network/9606.ENSP00000217456 | Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate. May play a role in adipocyte differentiation; Belongs to the str [...] |
| TXNL1 protein network | https://string-db.org/network/9606.ENSP00000217515 | Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV |
| MYL12A protein network | https://string-db.org/network/9606.ENSP00000217652 | Myosin regulatory light chain 12A; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Impl [...] |
| RNF125 protein network | https://string-db.org/network/9606.ENSP00000217740 | E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, [...] |
| IDH3G protein network | https://string-db.org/network/9606.ENSP00000217901 | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) in [...] |
| SLC25A43 protein network | https://string-db.org/network/9606.ENSP00000217909 | Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| MXRA5 protein network | https://string-db.org/network/9606.ENSP00000217939 | Matrix-remodeling-associated protein 5; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to T [...] |
| PSMD10 protein network | https://string-db.org/network/9606.ENSP00000217958 | 26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the b [...] |
| STS protein network | https://string-db.org/network/9606.ENSP00000217961 | Steryl-sulfatase; Conversion of sulfated steroid precursors to estrogens during pregnancy; Sulfatases |
| TBL1X protein network | https://string-db.org/network/9606.ENSP00000217964 | F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an e [...] |
| PGRMC1 protein network | https://string-db.org/network/9606.ENSP00000217971 | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction [...] |
| RHOXF1 protein network | https://string-db.org/network/9606.ENSP00000217999 | Rhox homeobox family member 1; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogene [...] |
| NXT2 protein network | https://string-db.org/network/9606.ENSP00000218004 | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export |
| GUCY2F protein network | https://string-db.org/network/9606.ENSP00000218006 | Retinal guanylyl cyclase 2; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of [...] |
| ATP1B4 protein network | https://string-db.org/network/9606.ENSP00000218008 | Protein ATP1B4; May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit; Belongs to the [...] |
| PAGE4 protein network | https://string-db.org/network/9606.ENSP00000218068 | Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reac [...] |
| GLRA2 protein network | https://string-db.org/network/9606.ENSP00000218075 | Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and bet [...] |
| STAG2 protein network | https://string-db.org/network/9606.ENSP00000218089 | Cohesin subunit SA-2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring [...] |
| F9 protein network | https://string-db.org/network/9606.ENSP00000218099 | Coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence [...] |
| ABCD1 protein network | https://string-db.org/network/9606.ENSP00000218104 | ATP-binding cassette sub-family D member 1; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity; Belongs to the ABC transporter superfamily. ABCD [...] |
| KCND1 protein network | https://string-db.org/network/9606.ENSP00000218176 | Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I( [...] |
| PQBP1 protein network | https://string-db.org/network/9606.ENSP00000218224 | Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innat [...] |
| PCSK1N protein network | https://string-db.org/network/9606.ENSP00000218230 | ProSAAS; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibit [...] |
| RAB40AL protein network | https://string-db.org/network/9606.ENSP00000218249 | Ras-related protein Rab-40A-like; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and su [...] |
| GPR50 protein network | https://string-db.org/network/9606.ENSP00000218316 | Melatonin-related receptor; Does not bind melatonin; G protein-coupled receptors, Class A orphans |
| RP2 protein network | https://string-db.org/network/9606.ENSP00000218340 | Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium memb [...] |
| USP11 protein network | https://string-db.org/network/9606.ENSP00000218348 | Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasom [...] |
| TIMP1 protein network | https://string-db.org/network/9606.ENSP00000218388 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them b [...] |
| ITIH6 protein network | https://string-db.org/network/9606.ENSP00000218436 | Inter-alpha-trypsin inhibitor heavy chain family member 6; Belongs to the ITIH family |
| GLA protein network | https://string-db.org/network/9606.ENSP00000218516 | Galactosidase alpha; Belongs to the glycosyl hydrolase 27 family |
| ATP12A protein network | https://string-db.org/network/9606.ENSP00000218548 | Potassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in va [...] |
| MLNR protein network | https://string-db.org/network/9606.ENSP00000218721 | Motilin receptor; Receptor for motilin; Belongs to the G-protein coupled receptor 1 family |
| SGCG protein network | https://string-db.org/network/9606.ENSP00000218867 | Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix |
| OLFM4 protein network | https://string-db.org/network/9606.ENSP00000219022 | Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell dif [...] |
| NTHL1 protein network | https://string-db.org/network/9606.ENSP00000219066 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary [...] |
| ZNF263 protein network | https://string-db.org/network/9606.ENSP00000219069 | Zinc finger protein 263; Might play an important role in basic cellular processes as a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| MMP2 protein network | https://string-db.org/network/9606.ENSP00000219070 | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, [...] |
| ORC6 protein network | https://string-db.org/network/9606.ENSP00000219097 | Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...] |
| C16orf70 protein network | https://string-db.org/network/9606.ENSP00000219139 | UPF0183 protein C16orf70; Chromosome 16 open reading frame 70; Belongs to the UPF0183 family |
| CORO1A protein network | https://string-db.org/network/9606.ENSP00000219150 | Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of th [...] |
| MT4 protein network | https://string-db.org/network/9606.ENSP00000219162 | Metallothionein-4; Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia; Metallothioneins |
| NUTF2 protein network | https://string-db.org/network/9606.ENSP00000219169 | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transp [...] |
| CBLN1 protein network | https://string-db.org/network/9606.ENSP00000219197 | Cerebellin-1; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at paralle [...] |
| ARL2BP protein network | https://string-db.org/network/9606.ENSP00000219204 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effec [...] |
| PLLP protein network | https://string-db.org/network/9606.ENSP00000219207 | Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are vo [...] |
| CCL22 protein network | https://string-db.org/network/9606.ENSP00000219235 | C-C motif chemokine 22; May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocy [...] |
| DHODH protein network | https://string-db.org/network/9606.ENSP00000219240 | Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor |
| CCL17 protein network | https://string-db.org/network/9606.ENSP00000219244 | C-C motif chemokine 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells [...] |
| POLR2C protein network | https://string-db.org/network/9606.ENSP00000219252 | DNA-directed RNA polymerase II subunit RPB3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| PARD6A protein network | https://string-db.org/network/9606.ENSP00000219255 | Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. A [...] |
| MMP15 protein network | https://string-db.org/network/9606.ENSP00000219271 | Matrix metalloproteinase-15; Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A; Belongs to the peptidase M10A family |
| USB1 protein network | https://string-db.org/network/9606.ENSP00000219281 | U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides [...] |
| CCDC113 protein network | https://string-db.org/network/9606.ENSP00000219299 | Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation |
| PRSS54 protein network | https://string-db.org/network/9606.ENSP00000219301 | Serine protease 54 |
| NME3 protein network | https://string-db.org/network/9606.ENSP00000219302 | Nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...] |
| PSMD7 protein network | https://string-db.org/network/9606.ENSP00000219313 | 26S proteasome non-ATPase regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| SETD6 protein network | https://string-db.org/network/9606.ENSP00000219315 | N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys- 310' of the RELA subunit of NF-kappa-B complex, leading to down- regulate NF-kappa-B transcription facto [...] |
| SMPD3 protein network | https://string-db.org/network/9606.ENSP00000219334 | Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arres [...] |
| PLA2G15 protein network | https://string-db.org/network/9606.ENSP00000219345 | Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phosph [...] |
| FA2H protein network | https://string-db.org/network/9606.ENSP00000219368 | Fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids; Belongs to the sterol desaturase family. SCS7 subfamily |
| CMC2 protein network | https://string-db.org/network/9606.ENSP00000219400 | COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis |
| PDIA2 protein network | https://string-db.org/network/9606.ENSP00000219406 | Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as [...] |
| ARHGDIG protein network | https://string-db.org/network/9606.ENSP00000219409 | Rho GDP-dissociation inhibitor 3; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post- translationally processed Rhob and Rhog proteins, b [...] |
| MPG protein network | https://string-db.org/network/9606.ENSP00000219431 | DNA-3-methyladenine glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions |
| HSDL1 protein network | https://string-db.org/network/9606.ENSP00000219439 | Inactive hydroxysteroid dehydrogenase-like protein 1; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily |
| WFDC1 protein network | https://string-db.org/network/9606.ENSP00000219454 | WAP four-disulfide core domain protein 1; Has growth inhibitory activity; WAP four-disulfide core domain containing |
| TSC2 protein network | https://string-db.org/network/9606.ENSP00000219476 | Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Act [...] |
| ZNF500 protein network | https://string-db.org/network/9606.ENSP00000219478 | Zinc finger protein 500; May be involved in transcriptional regulation; SCAN domain containing |
| NME4 protein network | https://string-db.org/network/9606.ENSP00000219479 | Nucleoside diphosphate kinase, mitochondrial; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-p [...] |
| DECR2 protein network | https://string-db.org/network/9606.ENSP00000219481 | Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered [...] |
| STUB1 protein network | https://string-db.org/network/9606.ENSP00000219548 | E3 ubiquitin-protein ligase CHIP; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded [...] |
| MEFV protein network | https://string-db.org/network/9606.ENSP00000219596 | Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, [...] |
| CRYM protein network | https://string-db.org/network/9606.ENSP00000219599 | Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyro [...] |
| CAPN15 protein network | https://string-db.org/network/9606.ENSP00000219611 | Calpain-15; Zinc fingers RANBP2-type ; Calpains |
| AQP8 protein network | https://string-db.org/network/9606.ENSP00000219660 | Aquaporin-8; Forms a water-specific channel; mercury-sensitive. Not permeable to glycerol or urea; Belongs to the MIP/aquaporin (TC 1.A.8) family |
| USP31 protein network | https://string-db.org/network/9606.ENSP00000219689 | Ubiquitin carboxyl-terminal hydrolase 31; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as tha [...] |
| TOX3 protein network | https://string-db.org/network/9606.ENSP00000219746 | TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Prote [...] |
| MAZ protein network | https://string-db.org/network/9606.ENSP00000219782 | Myc-associated zinc finger protein; May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promote [...] |
| CDIPT protein network | https://string-db.org/network/9606.ENSP00000219789 | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessi [...] |
| SLC6A2 protein network | https://string-db.org/network/9606.ENSP00000219833 | Sodium-dependent noradrenaline transporter; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sod [...] |
| KNOP1 protein network | https://string-db.org/network/9606.ENSP00000219837 | Lysine rich nucleolar protein 1 |
| MGA protein network | https://string-db.org/network/9606.ENSP00000219905 | MAX gene-associated protein; Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an acti [...] |
| AQP9 protein network | https://string-db.org/network/9606.ENSP00000219919 | Aquaporin-9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercur [...] |
| CSK protein network | https://string-db.org/network/9606.ENSP00000220003 | Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyr [...] |
| MTFMT protein network | https://string-db.org/network/9606.ENSP00000220058 | Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechani [...] |
| RASL12 protein network | https://string-db.org/network/9606.ENSP00000220062 | Ras-like protein family member 12; RAS type GTPase family |
| CTSH protein network | https://string-db.org/network/9606.ENSP00000220166 | Pro-cathepsin H; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family |
| EHD4 protein network | https://string-db.org/network/9606.ENSP00000220325 | EH domain-containing protein 4; ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport; EF-hand [...] |
| TGM5 protein network | https://string-db.org/network/9606.ENSP00000220420 | Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope o [...] |
| GABPB1 protein network | https://string-db.org/network/9606.ENSP00000220429 | GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Ankyrin repeat domain [...] |
| SCG3 protein network | https://string-db.org/network/9606.ENSP00000220478 | Member of the granin protein family that regulates the biogenesis of secretory granules . Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May [...] |
| DNAJC17 protein network | https://string-db.org/network/9606.ENSP00000220496 | DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription; DNAJ heat shock proteins |
| RHOV protein network | https://string-db.org/network/9606.ENSP00000220507 | Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family |
| VPS18 protein network | https://string-db.org/network/9606.ENSP00000220509 | Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...] |
| OIP5 protein network | https://string-db.org/network/9606.ENSP00000220514 | Protein Mis18-beta; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Belongs to the mis18 family |
| BLOC1S6 protein network | https://string-db.org/network/9606.ENSP00000220531 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| EXTL3 protein network | https://string-db.org/network/9606.ENSP00000220562 | Exostosin-like 3; Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycan [...] |
| AGO2 protein network | https://string-db.org/network/9606.ENSP00000220592 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a m [...] |
| PAG1 protein network | https://string-db.org/network/9606.ENSP00000220597 | Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin [...] |
| TG protein network | https://string-db.org/network/9606.ENSP00000220616 | Thyroglobulin; Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3); Belongs to the type-B carboxylesterase/lipase family |
| BRF2 protein network | https://string-db.org/network/9606.ENSP00000220659 | Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements u [...] |
| ZFAND1 protein network | https://string-db.org/network/9606.ENSP00000220669 | Zinc finger AN1-type containing 1 |
| RP1 protein network | https://string-db.org/network/9606.ENSP00000220676 | Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photorecepto [...] |
| RIPK2 protein network | https://string-db.org/network/9606.ENSP00000220751 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by ba [...] |
| CPQ protein network | https://string-db.org/network/9606.ENSP00000220763 | Carboxypeptidase Q; Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acid [...] |
| DECR1 protein network | https://string-db.org/network/9606.ENSP00000220764 | 2,4-dienoyl-CoA reductase, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-num [...] |
| SFRP1 protein network | https://string-db.org/network/9606.ENSP00000220772 | Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...] |
| PLAT protein network | https://string-db.org/network/9606.ENSP00000220809 | Tissue-type plasminogen activator; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteol [...] |
| DKK4 protein network | https://string-db.org/network/9606.ENSP00000220812 | Dickkopf-related protein 4; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...] |
| GDAP1 protein network | https://string-db.org/network/9606.ENSP00000220822 | Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission |
| EIF3E protein network | https://string-db.org/network/9606.ENSP00000220849 | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| EMC2 protein network | https://string-db.org/network/9606.ENSP00000220853 | ER membrane protein complex subunit 2; Tetratricopeptide repeat domain containing |
| CHRAC1 protein network | https://string-db.org/network/9606.ENSP00000220913 | Chromatin accessibility complex protein 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remode [...] |
| GML protein network | https://string-db.org/network/9606.ENSP00000220940 | Glycosyl-phosphatidylinositol-anchored molecule-like protein; May play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage; LY6/PLAUR domain containing |
| PYCRL protein network | https://string-db.org/network/9606.ENSP00000220966 | Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carb [...] |
| MTMR9 protein network | https://string-db.org/network/9606.ENSP00000221086 | Myotubularin-related protein 9; Probable pseudophosphatase. Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a p [...] |
| DCTN6 protein network | https://string-db.org/network/9606.ENSP00000221114 | Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily |
| GSR protein network | https://string-db.org/network/9606.ENSP00000221130 | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol |
| TNFRSF10A protein network | https://string-db.org/network/9606.ENSP00000221132 | Tumor necrosis factor receptor superfamily member 10A; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death [...] |
| PPP2CB protein network | https://string-db.org/network/9606.ENSP00000221138 | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase; P [...] |
| NEFM protein network | https://string-db.org/network/9606.ENSP00000221166 | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber |
| KCTD9 protein network | https://string-db.org/network/9606.ENSP00000221200 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to [...] |
| EXOSC5 protein network | https://string-db.org/network/9606.ENSP00000221233 | Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| PAF1 protein network | https://string-db.org/network/9606.ENSP00000221265 | RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of deve [...] |
| CYP4F3 protein network | https://string-db.org/network/9606.ENSP00000221307 | Docosahexaenoic acid omega-hydroxylase CYP4F3; Isoform CYP4F3A: Catalyzes the omega-hydroxylation of leukotriene-B(4), a potent chemoattractant for polymorphonuclear leukocytes, it has low activi [...] |
| ZNF180 protein network | https://string-db.org/network/9606.ENSP00000221327 | Zinc finger protein 180; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TULP2 protein network | https://string-db.org/network/9606.ENSP00000221399 | Tubby like protein 2; Belongs to the TUB family |
| DHDH protein network | https://string-db.org/network/9606.ENSP00000221403 | Dihydrodiol dehydrogenase; Belongs to the Gfo/Idh/MocA family |
| ECH1 protein network | https://string-db.org/network/9606.ENSP00000221418 | Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA |
| HNRNPL protein network | https://string-db.org/network/9606.ENSP00000221419 | Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for [...] |
| LHB protein network | https://string-db.org/network/9606.ENSP00000221421 | Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids; Endogenous ligands |
| KCNA7 protein network | https://string-db.org/network/9606.ENSP00000221444 | Potassium voltage-gated channel subfamily A member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...] |
| RELB protein network | https://string-db.org/network/9606.ENSP00000221452 | Transcription factor RelB; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, [...] |
| CLASRP protein network | https://string-db.org/network/9606.ENSP00000221455 | CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the [...] |
| LIN7B protein network | https://string-db.org/network/9606.ENSP00000221459 | Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...] |
| PPP1R37 protein network | https://string-db.org/network/9606.ENSP00000221462 | Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family |
| FCGRT protein network | https://string-db.org/network/9606.ENSP00000221466 | IgG receptor FcRn large subunit p51; Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunit [...] |
| CKM protein network | https://string-db.org/network/9606.ENSP00000221476 | Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy tran [...] |
| PEX11G protein network | https://string-db.org/network/9606.ENSP00000221480 | Peroxisomal membrane protein 11C; Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family |
| SLC17A7 protein network | https://string-db.org/network/9606.ENSP00000221485 | Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...] |
| RNASEH2A protein network | https://string-db.org/network/9606.ENSP00000221486 | Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the remova [...] |
| SF3A2 protein network | https://string-db.org/network/9606.ENSP00000221494 | Splicing factor 3A subunit 2; Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequenc [...] |
| AMH protein network | https://string-db.org/network/9606.ENSP00000221496 | Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived fro [...] |
| DKKL1 protein network | https://string-db.org/network/9606.ENSP00000221498 | Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may [...] |
| RETN protein network | https://string-db.org/network/9606.ENSP00000221515 | Resistin; Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells (By similarity). Potentially links obesity to diabetes (By similarity). Promotes chemotaxis [...] |
| RSPH6A protein network | https://string-db.org/network/9606.ENSP00000221538 | Radial spoke head 6 homolog A; Belongs to the flagellar radial spoke RSP4/6 family |
| TBC1D17 protein network | https://string-db.org/network/9606.ENSP00000221543 | TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transf [...] |
| AES protein network | https://string-db.org/network/9606.ENSP00000221561 | Amino-terminal enhancer of split; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the init [...] |
| SGTA protein network | https://string-db.org/network/9606.ENSP00000221566 | Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeti [...] |
| SNAPC2 protein network | https://string-db.org/network/9606.ENSP00000221573 | snRNA-activating protein complex subunit 2; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...] |
| FIZ1 protein network | https://string-db.org/network/9606.ENSP00000221665 | Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity); Zinc fingers C2H2-type |
| C19orf44 protein network | https://string-db.org/network/9606.ENSP00000221671 | Uncharacterized protein C19orf44; Chromosome 19 open reading frame 44 |
| CYP4F2 protein network | https://string-db.org/network/9606.ENSP00000221700 | Phylloquinone omega-hydroxylase CYP4F2; Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin [...] |
| EPHX3 protein network | https://string-db.org/network/9606.ENSP00000221730 | Epoxide hydrolase 3; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and [...] |
| SLC1A6 protein network | https://string-db.org/network/9606.ENSP00000221742 | Excitatory amino acid transporter 4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...] |
| LGALS13 protein network | https://string-db.org/network/9606.ENSP00000221797 | Galactoside-binding soluble lectin 13; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins |
| FBL protein network | https://string-db.org/network/9606.ENSP00000221801 | rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzin [...] |
| CLC protein network | https://string-db.org/network/9606.ENSP00000221804 | Galectin-10; Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg); Galectins |
| EBI3 protein network | https://string-db.org/network/9606.ENSP00000221847 | Interleukin-27 subunit beta; Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that [...] |
| TBCB protein network | https://string-db.org/network/9606.ENSP00000221855 | Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded [...] |
| FSD1 protein network | https://string-db.org/network/9606.ENSP00000221856 | Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization; Fibronectin type III domain containing |
| POLR2I protein network | https://string-db.org/network/9606.ENSP00000221859 | DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| APLP1 protein network | https://string-db.org/network/9606.ENSP00000221891 | Amyloid-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By sim [...] |
| CCDC9 protein network | https://string-db.org/network/9606.ENSP00000221922 | Coiled-coil domain containing 9 |
| TGFB1 protein network | https://string-db.org/network/9606.ENSP00000221930 | Transforming growth factor beta-1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific recep [...] |
| CEACAM4 protein network | https://string-db.org/network/9606.ENSP00000221954 | Carcinoembryonic antigen-related cell adhesion molecule 4; Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles; Carcinoembryonic antigen related cell [...] |
| PLIN3 protein network | https://string-db.org/network/9606.ENSP00000221957 | Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network; Perilipins |
| CD79A protein network | https://string-db.org/network/9606.ENSP00000221972 | B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell [...] |
| LIM2 protein network | https://string-db.org/network/9606.ENSP00000221973 | Lens intrinsic membrane protein 2 |
| NKG7 protein network | https://string-db.org/network/9606.ENSP00000221978 | Protein NKG7; Natural killer cell granule protein 7; Belongs to the PMP-22/EMP/MP20 family |
| ICAM5 protein network | https://string-db.org/network/9606.ENSP00000221980 | Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2); Ig-like cell adhesion molecule family |
| CEACAM5 protein network | https://string-db.org/network/9606.ENSP00000221992 | Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins; CD molecul [...] |
| CRX protein network | https://string-db.org/network/9606.ENSP00000221996 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin gen [...] |
| SULT2A1 protein network | https://string-db.org/network/9606.ENSP00000222002 | Bile salt sulfotransferase; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal [...] |
| CDC37 protein network | https://string-db.org/network/9606.ENSP00000222005 | Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits H [...] |
| RABAC1 protein network | https://string-db.org/network/9606.ENSP00000222008 | Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPas [...] |
| CNFN protein network | https://string-db.org/network/9606.ENSP00000222032 | Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia |
| ZNRF4 protein network | https://string-db.org/network/9606.ENSP00000222033 | E3 ubiquitin-protein ligase ZNRF4; E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum. Could have a role in [...] |
| HAS1 protein network | https://string-db.org/network/9606.ENSP00000222115 | Hyaluronan synthase 1; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...] |
| RAB3D protein network | https://string-db.org/network/9606.ENSP00000222120 | Ras-related protein Rab-3D; Protein transport. Probably involved in regulated exocytosis (By similarity); Belongs to the small GTPase superfamily. Rab family |
| DBP protein network | https://string-db.org/network/9606.ENSP00000222122 | D site-binding protein; This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential [...] |
| EPOR protein network | https://string-db.org/network/9606.ENSP00000222139 | Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STA [...] |
| RASIP1 protein network | https://string-db.org/network/9606.ENSP00000222145 | Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GT [...] |
| GCDH protein network | https://string-db.org/network/9606.ENSP00000222214 | Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptop [...] |
| DNASE2 protein network | https://string-db.org/network/9606.ENSP00000222219 | Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during deve [...] |
| LENG1 protein network | https://string-db.org/network/9606.ENSP00000222224 | Leukocyte receptor cluster member 1; Spliceosomal C complex |
| RPL18A protein network | https://string-db.org/network/9606.ENSP00000222247 | Belongs to the eukaryotic ribosomal protein eL20 family. |
| SLC5A5 protein network | https://string-db.org/network/9606.ENSP00000222248 | Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Solute carriers |
| ARRDC2 protein network | https://string-db.org/network/9606.ENSP00000222250 | Arrestin domain containing 2; Belongs to the arrestin family |
| PIK3R2 protein network | https://string-db.org/network/9606.ENSP00000222254 | Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) t [...] |
| RAB3A protein network | https://string-db.org/network/9606.ENSP00000222256 | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve ter [...] |
| COMP protein network | https://string-db.org/network/9606.ENSP00000222271 | Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. C [...] |
| TMEM147 protein network | https://string-db.org/network/9606.ENSP00000222284 | Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane . Negatively regulates CHRM3-mediated calcium mobilization and activation of R [...] |
| GAPDHS protein network | https://string-db.org/network/9606.ENSP00000222286 | Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the sp [...] |
| USF2 protein network | https://string-db.org/network/9606.ENSP00000222305 | Upstream stimulatory factor 2; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters; Basic helix-loop- [...] |
| ERF protein network | https://string-db.org/network/9606.ENSP00000222329 | ETS domain-containing transcription factor ERF; Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Re [...] |
| GSK3A protein network | https://string-db.org/network/9606.ENSP00000222330 | Glycogen synthase kinase-3 alpha; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcript [...] |
| SIPA1L3 protein network | https://string-db.org/network/9606.ENSP00000222345 | Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens; PDZ domain containi [...] |
| CADM4 protein network | https://string-db.org/network/9606.ENSP00000222374 | Cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity; C2-set domain containing |
| PON1 protein network | https://string-db.org/network/9606.ENSP00000222381 | Serum paraoxonase/arylesterase 1; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactone [...] |
| CYP3A43 protein network | https://string-db.org/network/9606.ENSP00000222382 | Cytochrome P450 3A43; Exhibits low testosterone 6-beta-hydroxylase activity; Cytochrome P450 family 3 |
| ABCF2 protein network | https://string-db.org/network/9606.ENSP00000222388 | ATP binding cassette subfamily F member 2 |
| HGF protein network | https://string-db.org/network/9606.ENSP00000222390 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. A [...] |
| LAMB1 protein network | https://string-db.org/network/9606.ENSP00000222399 | Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| UBE2D4 protein network | https://string-db.org/network/9606.ENSP00000222402 | Ubiquitin-conjugating enzyme E2 D4; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquiti [...] |
| WNT16 protein network | https://string-db.org/network/9606.ENSP00000222462 | Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| CPA2 protein network | https://string-db.org/network/9606.ENSP00000222481 | M14 carboxypeptidases |
| CPA4 protein network | https://string-db.org/network/9606.ENSP00000222482 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; B [...] |
| GTPBP10 protein network | https://string-db.org/network/9606.ENSP00000222511 | GTP-binding protein 10; May be involved in the ribosome maturation process. Complements an ObgE(CgtA) function in E.coli ribosome maturation. Plays a role of GTPase in vitro. When missing, disorg [...] |
| TFPI2 protein network | https://string-db.org/network/9606.ENSP00000222543 | Tissue factor pathway inhibitor 2; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effec [...] |
| BET1 protein network | https://string-db.org/network/9606.ENSP00000222547 | BET1 homolog; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER-derived vesicles with the cis-Golgi membrane (By simila [...] |
| NAMPT protein network | https://string-db.org/network/9606.ENSP00000222553 | Nicotinamide phosphoribosyltransferase; Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis [...] |
| TWISTNB protein network | https://string-db.org/network/9606.ENSP00000222567 | DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| PON2 protein network | https://string-db.org/network/9606.ENSP00000222572 | Serum paraoxonase/arylesterase 2; Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Preve [...] |
| ITGB8 protein network | https://string-db.org/network/9606.ENSP00000222573 | Integrin beta-8; Integrin alpha-V/beta-8 is a receptor for fibronectin |
| HBP1 protein network | https://string-db.org/network/9606.ENSP00000222574 | HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferent [...] |
| SP4 protein network | https://string-db.org/network/9606.ENSP00000222584 | Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator; Belongs to the Sp1 C2H2-type zinc-finger protein family |
| DLX5 protein network | https://string-db.org/network/9606.ENSP00000222598 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulat [...] |
| MPP6 protein network | https://string-db.org/network/9606.ENSP00000222644 | MAGUK p55 subfamily member 6; Membrane associated guanylate kinases; Belongs to the MAGUK family |
| OGDH protein network | https://string-db.org/network/9606.ENSP00000222673 | 2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of [...] |
| NPVF protein network | https://string-db.org/network/9606.ENSP00000222674 | Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-i [...] |
| CAV2 protein network | https://string-db.org/network/9606.ENSP00000222693 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein [...] |
| HOXA2 protein network | https://string-db.org/network/9606.ENSP00000222718 | Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| LFNG protein network | https://string-db.org/network/9606.ENSP00000222725 | Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of [...] |
| HOXA5 protein network | https://string-db.org/network/9606.ENSP00000222726 | Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| HOXA6 protein network | https://string-db.org/network/9606.ENSP00000222728 | Homeobox protein Hox-A6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| TSPAN12 protein network | https://string-db.org/network/9606.ENSP00000222747 | Tetraspanin-12; Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin [...] |
| HOXA13 protein network | https://string-db.org/network/9606.ENSP00000222753 | Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the [...] |
| CHN2 protein network | https://string-db.org/network/9606.ENSP00000222792 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression fr [...] |
| ABHD11 protein network | https://string-db.org/network/9606.ENSP00000222800 | Protein ABHD11; Abhydrolase domain containing 11; Belongs to the AB hydrolase superfamily |
| FKBP14 protein network | https://string-db.org/network/9606.ENSP00000222803 | Peptidyl-prolyl cis-trans isomerase FKBP14; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing |
| STX1A protein network | https://string-db.org/network/9606.ENSP00000222812 | Syntaxin-1A; Plays a role in hormone and neurotransmitter exocytosis (By similarity). Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)- regulat [...] |
| NOD1 protein network | https://string-db.org/network/9606.ENSP00000222823 | Nucleotide-binding oligomerization domain-containing protein 1; Enhances caspase-9-mediated apoptosis. Induces NF-kappa- B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellula [...] |
| PDAP1 protein network | https://string-db.org/network/9606.ENSP00000222968 | 28 kDa heat- and acid-stable phosphoprotein; Enhances PDGFA-stimulated cell growth in fibroblasts, but inhibits the mitogenic effect of PDGFB |
| CYP3A5 protein network | https://string-db.org/network/9606.ENSP00000222982 | Cytochrome P450 3A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| SNX8 protein network | https://string-db.org/network/9606.ENSP00000222990 | Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network; PX-BAR domain [...] |
| WASL protein network | https://string-db.org/network/9606.ENSP00000223023 | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in t [...] |
| HYAL4 protein network | https://string-db.org/network/9606.ENSP00000223026 | Hyaluronidase-4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic l [...] |
| AIMP2 protein network | https://string-db.org/network/9606.ENSP00000223029 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl- tRNA synthase complex. Mediates ubiquitination and degradation of FUBP [...] |
| PCOLCE protein network | https://string-db.org/network/9606.ENSP00000223061 | Procollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity |
| RBM28 protein network | https://string-db.org/network/9606.ENSP00000223073 | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes; RNA binding motif containing |
| SERPINE1 protein network | https://string-db.org/network/9606.ENSP00000223095 | Plasminogen activator inhibitor 1; Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction [...] |
| MOGAT3 protein network | https://string-db.org/network/9606.ENSP00000223114 | 2-acylglycerol O-acyltransferase 3; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by [...] |
| PLOD3 protein network | https://string-db.org/network/9606.ENSP00000223127 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units a [...] |
| RPA3 protein network | https://string-db.org/network/9606.ENSP00000223129 | Replication protein A 14 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates that form during DNA replicati [...] |
| FIS1 protein network | https://string-db.org/network/9606.ENSP00000223136 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission me [...] |
| GLCCI1 protein network | https://string-db.org/network/9606.ENSP00000223145 | Glucocorticoid-induced transcript 1 protein; Glucocorticoid induced 1 |
| MYL10 protein network | https://string-db.org/network/9606.ENSP00000223167 | Myosin regulatory light chain 10; EF-hand domain containing |
| CEP41 protein network | https://string-db.org/network/9606.ENSP00000223208 | Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the b [...] |
| ZNF862 protein network | https://string-db.org/network/9606.ENSP00000223210 | Zinc finger protein 862; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MEST protein network | https://string-db.org/network/9606.ENSP00000223215 | Mesoderm-specific transcript homolog protein; Mesoderm specific transcript; Belongs to the AB hydrolase superfamily |
| YAE1D1 protein network | https://string-db.org/network/9606.ENSP00000223273 | The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery . May be required for biogenesi [...] |
| GIMAP2 protein network | https://string-db.org/network/9606.ENSP00000223293 | GTPase IMAP family member 2; The heterodimer formed by GIMAP2 and GIMAP7 has GTPase activity. In contrast, GIMAP2 has no GTPase activity by itself |
| PSMA2 protein network | https://string-db.org/network/9606.ENSP00000223321 | Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| MRPL32 protein network | https://string-db.org/network/9606.ENSP00000223324 | Mitochondrial ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family |
| AEBP1 protein network | https://string-db.org/network/9606.ENSP00000223357 | Adipocyte enhancer-binding protein 1; May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positi [...] |
| MYL7 protein network | https://string-db.org/network/9606.ENSP00000223364 | Myosin regulatory light chain 2, atrial isoform; EF-hand domain containing |
| GCK protein network | https://string-db.org/network/9606.ENSP00000223366 | Glucokinase; Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective [...] |
| YKT6 protein network | https://string-db.org/network/9606.ENSP00000223369 | Synaptobrevin homolog YKT6; Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic [...] |
| CLIP2 protein network | https://string-db.org/network/9606.ENSP00000223398 | CAP-Gly domain-containing linker protein 2; Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons li [...] |
| ZNF688 protein network | https://string-db.org/network/9606.ENSP00000223459 | Zinc finger protein 688; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CHMP5 protein network | https://string-db.org/network/9606.ENSP00000223500 | Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodie [...] |
| FKTN protein network | https://string-db.org/network/9606.ENSP00000223528 | Fukutin; Glycosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carboh [...] |
| SEC61B protein network | https://string-db.org/network/9606.ENSP00000223641 | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SEC61-beta family |
| C5 protein network | https://string-db.org/network/9606.ENSP00000223642 | Complement C5; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site [...] |
| TNFSF8 protein network | https://string-db.org/network/9606.ENSP00000223795 | Tumor necrosis factor ligand superfamily member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells |
| RLN1 protein network | https://string-db.org/network/9606.ENSP00000223862 | Prorelaxin H1; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy [...] |
| PLGRKT protein network | https://string-db.org/network/9606.ENSP00000223864 | Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator-dependent cell surface plasminogen activa [...] |
| EDF1 protein network | https://string-db.org/network/9606.ENSP00000224073 | Endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity [...] |
| SETX protein network | https://string-db.org/network/9606.ENSP00000224140 | Probable helicase senataxin; Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA [...] |
| C8G protein network | https://string-db.org/network/9606.ENSP00000224181 | Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the pol [...] |
| BLNK protein network | https://string-db.org/network/9606.ENSP00000224337 | B-cell linker protein; Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outco [...] |
| CYP26A1 protein network | https://string-db.org/network/9606.ENSP00000224356 | Cytochrome P450 26A1; Plays a key role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA. Capable of both 4-hydroxylation and 18 [...] |
| ATE1 protein network | https://string-db.org/network/9606.ENSP00000224652 | Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradatio [...] |
| SFXN3 protein network | https://string-db.org/network/9606.ENSP00000224807 | Sideroflexin-3; Potential iron transporter; Sideroflexins |
| FBXL15 protein network | https://string-db.org/network/9606.ENSP00000224862 | F-box/LRR-repeat protein 15; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal d [...] |
| OBFC1 protein network | https://string-db.org/network/9606.ENSP00000224950 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...] |
| DNAJC12 protein network | https://string-db.org/network/9606.ENSP00000225171 | DnaJ heat shock protein family member C12 |
| PPIF protein network | https://string-db.org/network/9606.ENSP00000225174 | Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involv [...] |
| TBC1D12 protein network | https://string-db.org/network/9606.ENSP00000225235 | TBC1 domain family member 12; May act as a GTPase-activating protein for Rab family protein(s) |
| MPO protein network | https://string-db.org/network/9606.ENSP00000225275 | Myeloperoxidase; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyz [...] |
| ST6GALNAC2 protein network | https://string-db.org/network/9606.ENSP00000225276 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Sialyltransferases |
| DHX33 protein network | https://string-db.org/network/9606.ENSP00000225296 | Putative ATP-dependent RNA helicase DHX33; Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitmen [...] |
| UTP18 protein network | https://string-db.org/network/9606.ENSP00000225298 | U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex |
| P2RX5 protein network | https://string-db.org/network/9606.ENSP00000225328 | P2X purinoceptor 5; Receptor for ATP that acts as a ligand-gated ion channel; Minor histocompatibility antigens |
| EPX protein network | https://string-db.org/network/9606.ENSP00000225371 | Eosinophil peroxidase; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by i [...] |
| CRYBA1 protein network | https://string-db.org/network/9606.ENSP00000225387 | Beta-crystallin A3; Crystallins are the dominant structural components of the vertebrate eye lens |
| NUFIP2 protein network | https://string-db.org/network/9606.ENSP00000225388 | Nuclear fragile X mental retardation-interacting protein 2; Binds RNA |
| RPL19 protein network | https://string-db.org/network/9606.ENSP00000225430 | Ribosomal protein L19; Belongs to the eukaryotic ribosomal protein eL19 family |
| CSF3 protein network | https://string-db.org/network/9606.ENSP00000225474 | Granulocyte colony-stimulating factor; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 [...] |
| SUPT4H1 protein network | https://string-db.org/network/9606.ENSP00000225504 | Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. D [...] |
| WNT3 protein network | https://string-db.org/network/9606.ENSP00000225512 | Proto-oncogene Wnt-3; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developin [...] |
| SHPK protein network | https://string-db.org/network/9606.ENSP00000225519 | Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism |
| TAX1BP3 protein network | https://string-db.org/network/9606.ENSP00000225525 | Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling path [...] |
| P2RX1 protein network | https://string-db.org/network/9606.ENSP00000225538 | P2X purinoceptor 1; Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to b [...] |
| KRT37 protein network | https://string-db.org/network/9606.ENSP00000225550 | Keratin, type I cuticular Ha7; Keratins, type I; Belongs to the intermediate filament family |
| GOSR2 protein network | https://string-db.org/network/9606.ENSP00000225567 | Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial- Golgi to the trans-Golgi network; Belongs to the GOSR2 family |
| PNPO protein network | https://string-db.org/network/9606.ENSP00000225573 | Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) |
| TVP23C protein network | https://string-db.org/network/9606.ENSP00000225576 | Trans-golgi network vesicle protein 23 homolog C; Belongs to the TVP23 family |
| RPS6KB1 protein network | https://string-db.org/network/9606.ENSP00000225577 | Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth a [...] |
| PIGL protein network | https://string-db.org/network/9606.ENSP00000225609 | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol; Belongs to the PIGL fami [...] |
| PFN1 protein network | https://string-db.org/network/9606.ENSP00000225655 | Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By b [...] |
| SLC25A11 protein network | https://string-db.org/network/9606.ENSP00000225665 | Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxyl [...] |
| RASD1 protein network | https://string-db.org/network/9606.ENSP00000225688 | Dexamethasone-induced Ras-related protein 1; Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similar [...] |
| C1QBP protein network | https://string-db.org/network/9606.ENSP00000225698 | Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome [...] |
| CPD protein network | https://string-db.org/network/9606.ENSP00000225719 | M14 carboxypeptidases |
| GOSR1 protein network | https://string-db.org/network/9606.ENSP00000225724 | Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or sol [...] |
| CCDC47 protein network | https://string-db.org/network/9606.ENSP00000225726 | Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum . Required for proper protein degradation via the ERAD pathway . Has an essential role in the maintenance of end [...] |
| MED31 protein network | https://string-db.org/network/9606.ENSP00000225728 | Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| DRG2 protein network | https://string-db.org/network/9606.ENSP00000225729 | Developmentally-regulated GTP-binding protein 2; May play a role in cell proliferation, differentiation and death; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family |
| AKAP10 protein network | https://string-db.org/network/9606.ENSP00000225737 | A-kinase anchor protein 10, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma m [...] |
| SYNGR2 protein network | https://string-db.org/network/9606.ENSP00000225777 | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the f [...] |
| DDX5 protein network | https://string-db.org/network/9606.ENSP00000225792 | Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a [...] |
| ASIC2 protein network | https://string-db.org/network/9606.ENSP00000225823 | Acid sensing ion channel subunit 2 |
| CCL2 protein network | https://string-db.org/network/9606.ENSP00000225831 | C-C motif chemokine 2; Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis [...] |
| CCL1 protein network | https://string-db.org/network/9606.ENSP00000225842 | C-C motif chemokine 1; Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8; Belongs to the intercrine beta (chemokine CC) family |
| CCL13 protein network | https://string-db.org/network/9606.ENSP00000225844 | C-C motif chemokine 13; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accu [...] |
| KRT32 protein network | https://string-db.org/network/9606.ENSP00000225899 | Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family |
| KAT2A protein network | https://string-db.org/network/9606.ENSP00000225916 | Histone acetyltransferase KAT2A; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription ac [...] |
| NAGLU protein network | https://string-db.org/network/9606.ENSP00000225927 | Alpha-N-acetylglucosaminidase; Involved in the degradation of heparan sulfate |
| ABI3 protein network | https://string-db.org/network/9606.ENSP00000225941 | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family |
| COL1A1 protein network | https://string-db.org/network/9606.ENSP00000225964 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Collagens |
| MRPL27 protein network | https://string-db.org/network/9606.ENSP00000225969 | Mitochondrial ribosomal protein L27 |
| LRRC59 protein network | https://string-db.org/network/9606.ENSP00000225972 | Leucine-rich repeat-containing protein 59; Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear [...] |
| HDAC5 protein network | https://string-db.org/network/9606.ENSP00000225983 | Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| DUSP3 protein network | https://string-db.org/network/9606.ENSP00000226004 | Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dep [...] |
| CACNG1 protein network | https://string-db.org/network/9606.ENSP00000226021 | Voltage-dependent calcium channel gamma-1 subunit; This protein is a subunit of the dihydropyridine (DHP) sensitive calcium channel. Plays a role in excitation-contraction coupling. The skeletal [...] |
| HLF protein network | https://string-db.org/network/9606.ENSP00000226067 | Hepatic leukemia factor; HLF, PAR bZIP transcription factor; Belongs to the bZIP family. PAR subfamily |
| EFNB3 protein network | https://string-db.org/network/9606.ENSP00000226091 | Ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithel [...] |
| RANGRF protein network | https://string-db.org/network/9606.ENSP00000226105 | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. In cardiac cells seems to regulate the cell surface localization of SCN5A |
| RCVRN protein network | https://string-db.org/network/9606.ENSP00000226193 | Recoverin; Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent mann [...] |
| MYH1 protein network | https://string-db.org/network/9606.ENSP00000226207 | Myosin-1; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family |
| VTN protein network | https://string-db.org/network/9606.ENSP00000226218 | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of th [...] |
| TNFAIP1 protein network | https://string-db.org/network/9606.ENSP00000226225 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of c [...] |
| TMEM97 protein network | https://string-db.org/network/9606.ENSP00000226230 | Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, w [...] |
| FOXN1 protein network | https://string-db.org/network/9606.ENSP00000226247 | Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts [...] |
| ALDOC protein network | https://string-db.org/network/9606.ENSP00000226253 | Belongs to the class I fructose-bisphosphate aldolase family |
| CD38 protein network | https://string-db.org/network/9606.ENSP00000226279 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-indu [...] |
| IBSP protein network | https://string-db.org/network/9606.ENSP00000226284 | Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cel [...] |
| LAP3 protein network | https://string-db.org/network/9606.ENSP00000226299 | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; [...] |
| CXCL6 protein network | https://string-db.org/network/9606.ENSP00000226317 | C-X-C motif chemokine 6; Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properti [...] |
| JADE1 protein network | https://string-db.org/network/9606.ENSP00000226319 | Protein Jade-1; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acety [...] |
| AFM protein network | https://string-db.org/network/9606.ENSP00000226355 | Afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitam [...] |
| PHOX2B protein network | https://string-db.org/network/9606.ENSP00000226382 | Paired mesoderm homeobox protein 2B; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neu [...] |
| GNRHR protein network | https://string-db.org/network/9606.ENSP00000226413 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing ho [...] |
| CWH43 protein network | https://string-db.org/network/9606.ENSP00000226432 | PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation |
| SULT1E1 protein network | https://string-db.org/network/9606.ENSP00000226444 | Estrogen sulfotransferase; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in [...] |
| SMR3A protein network | https://string-db.org/network/9606.ENSP00000226460 | Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification |
| PF4V1 protein network | https://string-db.org/network/9606.ENSP00000226524 | Platelet factor 4 variant; Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro) |
| NFKB1 protein network | https://string-db.org/network/9606.ENSP00000226574 | Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are in [...] |
| MANBA protein network | https://string-db.org/network/9606.ENSP00000226578 | Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides; Mannosidases type beta |
| IL2 protein network | https://string-db.org/network/9606.ENSP00000226730 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune re [...] |
| WFS1 protein network | https://string-db.org/network/9606.ENSP00000226760 | Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store; Deafness associated genes |
| GAR1 protein network | https://string-db.org/network/9606.ENSP00000226796 | H/ACA ribonucleoprotein complex subunit 1; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...] |
| FRG1 protein network | https://string-db.org/network/9606.ENSP00000226798 | Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transp [...] |
| CLNK protein network | https://string-db.org/network/9606.ENSP00000226951 | Cytokine-dependent hematopoietic cell linker; Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-me [...] |
| FAM149A protein network | https://string-db.org/network/9606.ENSP00000227065 | Protein FAM149A; Family with sequence similarity 149 member A |
| CD82 protein network | https://string-db.org/network/9606.ENSP00000227155 | CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway; Belongs to the tetraspanin (TM4SF) family |
| SPI1 protein network | https://string-db.org/network/9606.ENSP00000227163 | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'- GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be sp [...] |
| CTSC protein network | https://string-db.org/network/9606.ENSP00000227266 | Dipeptidyl peptidase 1; Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot o [...] |
| ZPR1 protein network | https://string-db.org/network/9606.ENSP00000227322 | Zinc finger protein ZPR1; Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the [...] |
| CRTAM protein network | https://string-db.org/network/9606.ENSP00000227348 | Cytotoxic and regulatory T-cell molecule; Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cel [...] |
| C11orf63 protein network | https://string-db.org/network/9606.ENSP00000227349 | Jhy protein homolog; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces |
| DTX4 protein network | https://string-db.org/network/9606.ENSP00000227451 | E3 ubiquitin-protein ligase DTX4; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity [...] |
| UNC93B1 protein network | https://string-db.org/network/9606.ENSP00000227471 | Protein unc-93 homolog B1; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of T [...] |
| PUS3 protein network | https://string-db.org/network/9606.ENSP00000227474 | tRNA pseudouridine(38/39) synthase; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family |
| CCND1 protein network | https://string-db.org/network/9606.ENSP00000227507 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...] |
| CCDC86 protein network | https://string-db.org/network/9606.ENSP00000227520 | Coiled-coil domain containing 86 |
| PRPF19 protein network | https://string-db.org/network/9606.ENSP00000227524 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex [...] |
| TMEM109 protein network | https://string-db.org/network/9606.ENSP00000227525 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By s [...] |
| PANX1 protein network | https://string-db.org/network/9606.ENSP00000227638 | Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis; Pannexins |
| APOC3 protein network | https://string-db.org/network/9606.ENSP00000227667 | Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Int [...] |
| IL10RA protein network | https://string-db.org/network/9606.ENSP00000227752 | Interleukin-10 receptor subunit alpha; Receptor for IL10; binds IL10 with a high affinity; CD molecules |
| GALNT18 protein network | https://string-db.org/network/9606.ENSP00000227756 | Polypeptide N-acetylgalactosaminyltransferase 18; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| PDHX protein network | https://string-db.org/network/9606.ENSP00000227868 | Pyruvate dehydrogenase protein X component, mitochondrial; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenas [...] |
| SLC15A3 protein network | https://string-db.org/network/9606.ENSP00000227880 | Solute carrier family 15 member 3; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity); Solute carriers |
| SCGB2A2 protein network | https://string-db.org/network/9606.ENSP00000227918 | Mammaglobin-A; Secretoglobin family 2A member 2; Secretoglobins |
| DGAT2 protein network | https://string-db.org/network/9606.ENSP00000228027 | Diacylglycerol O-acyltransferase 2; Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substr [...] |
| C11orf58 protein network | https://string-db.org/network/9606.ENSP00000228136 | Small acidic protein; Chromosome 11 open reading frame 58; Belongs to the SMAP family |
| YBX3 protein network | https://string-db.org/network/9606.ENSP00000228251 | Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor. Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have [...] |
| KITLG protein network | https://string-db.org/network/9606.ENSP00000228280 | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogen [...] |
| SART3 protein network | https://string-db.org/network/9606.ENSP00000228284 | Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRN [...] |
| SLC25A3 protein network | https://string-db.org/network/9606.ENSP00000228318 | Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitoc [...] |
| POLR3B protein network | https://string-db.org/network/9606.ENSP00000228347 | DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest co [...] |
| CD69 protein network | https://string-db.org/network/9606.ENSP00000228434 | Early activation antigen CD69; Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets; C-type lectin domain [...] |
| PRDM4 protein network | https://string-db.org/network/9606.ENSP00000228437 | PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily |
| CLEC2B protein network | https://string-db.org/network/9606.ENSP00000228438 | C-type lectin domain family 2 member B |
| SELPLG protein network | https://string-db.org/network/9606.ENSP00000228463 | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over va [...] |
| ASIC1 protein network | https://string-db.org/network/9606.ENSP00000228468 | Acid-sensing ion channel 1; Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channe [...] |
| DAO protein network | https://string-db.org/network/9606.ENSP00000228476 | D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent whi [...] |
| KCTD10 protein network | https://string-db.org/network/9606.ENSP00000228495 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiqui [...] |
| MLEC protein network | https://string-db.org/network/9606.ENSP00000228506 | Malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity); Oligosaccharyltransferase [...] |
| CSRNP2 protein network | https://string-db.org/network/9606.ENSP00000228515 | Cysteine/serine-rich nuclear protein 2; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May play a role in apoptosis; Protein phosphatase [...] |
| IL23A protein network | https://string-db.org/network/9606.ENSP00000228534 | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acu [...] |
| SYT10 protein network | https://string-db.org/network/9606.ENSP00000228567 | Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)- dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required f [...] |
| CYP27B1 protein network | https://string-db.org/network/9606.ENSP00000228606 | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyv [...] |
| MYF6 protein network | https://string-db.org/network/9606.ENSP00000228641 | Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein; Basic helix-loop-heli [...] |
| MYF5 protein network | https://string-db.org/network/9606.ENSP00000228644 | Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occ [...] |
| GLI1 protein network | https://string-db.org/network/9606.ENSP00000228682 | Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'- GACCACCCA-3'. May regulate the transcription of specific genes during normal development. Ma [...] |
| PPM1H protein network | https://string-db.org/network/9606.ENSP00000228705 | Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation; Belongs to the PP2C family |
| LTA4H protein network | https://string-db.org/network/9606.ENSP00000228740 | Leukotriene A-4 hydrolase; Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity; M1 metallopeptidas [...] |
| ELK3 protein network | https://string-db.org/network/9606.ENSP00000228741 | ETS domain-containing protein Elk-3; May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum res [...] |
| ITFG2 protein network | https://string-db.org/network/9606.ENSP00000228799 | KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 [...] |
| PRR4 protein network | https://string-db.org/network/9606.ENSP00000228811 | Proline-rich protein 4; Proline rich 4 |
| PARP11 protein network | https://string-db.org/network/9606.ENSP00000228820 | Poly [ADP-ribose] polymerase 11; Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). In vitro, exhibits mono(ADP-ribosyl) transferase activity [...] |
| ARPC3 protein network | https://string-db.org/network/9606.ENSP00000228825 | Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promot [...] |
| FGF6 protein network | https://string-db.org/network/9606.ENSP00000228837 | Fibroblast growth factor 6; Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration; Bel [...] |
| MYL2 protein network | https://string-db.org/network/9606.ENSP00000228841 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a ro [...] |
| RAD51AP1 protein network | https://string-db.org/network/9606.ENSP00000228843 | RAD51-associated protein 1; May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally coopera [...] |
| AKAP3 protein network | https://string-db.org/network/9606.ENSP00000228850 | A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins |
| CREBL2 protein network | https://string-db.org/network/9606.ENSP00000228865 | cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cel [...] |
| CDKN1B protein network | https://string-db.org/network/9606.ENSP00000228872 | Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SP [...] |
| GPRC5D protein network | https://string-db.org/network/9606.ENSP00000228887 | G protein-coupled receptor class C group 5 member D |
| LTBR protein network | https://string-db.org/network/9606.ENSP00000228918 | Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a r [...] |
| OAS3 protein network | https://string-db.org/network/9606.ENSP00000228928 | 2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in ot [...] |
| ART4 protein network | https://string-db.org/network/9606.ENSP00000228936 | ADP-ribosyltransferase 4; Belongs to the Arg-specific ADP-ribosyltransferase family |
| MGP protein network | https://string-db.org/network/9606.ENSP00000228938 | Matrix Gla protein; Gla domain containing |
| ARHGDIB protein network | https://string-db.org/network/9606.ENSP00000228945 | Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates [...] |
| RERGL protein network | https://string-db.org/network/9606.ENSP00000229002 | Ras-related and estrogen-regulated growth inhibitor-like protein; Binds GDP/GTP and may possess intrinsic GTPase activity; RAS type GTPase family |
| FZD10 protein network | https://string-db.org/network/9606.ENSP00000229030 | Frizzled-10; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| IL26 protein network | https://string-db.org/network/9606.ENSP00000229134 | Interleukin-26; May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAP [...] |
| IFNG protein network | https://string-db.org/network/9606.ENSP00000229135 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent [...] |
| NUP107 protein network | https://string-db.org/network/9606.ENSP00000229179 | Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to [...] |
| CNOT2 protein network | https://string-db.org/network/9606.ENSP00000229195 | CCR4-NOT transcription complex subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...] |
| KRR1 protein network | https://string-db.org/network/9606.ENSP00000229214 | KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) |
| MRPL51 protein network | https://string-db.org/network/9606.ENSP00000229238 | Mitochondrial ribosomal protein L51; Belongs to the mitochondrion-specific ribosomal protein mL51 family |
| GAPDH protein network | https://string-db.org/network/9606.ENSP00000229239 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. P [...] |
| ACRBP protein network | https://string-db.org/network/9606.ENSP00000229243 | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin; Armadillo-like helical domain containing |
| GNB3 protein network | https://string-db.org/network/9606.ENSP00000229264 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...] |
| CHPT1 protein network | https://string-db.org/network/9606.ENSP00000229266 | Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP- choline. It thereby plays a central role in the formation and maintenance of vesicular membranes |
| USP5 protein network | https://string-db.org/network/9606.ENSP00000229268 | Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin d [...] |
| TPI1 protein network | https://string-db.org/network/9606.ENSP00000229270 | Triosephosphate isomerase 1; Belongs to the triosephosphate isomerase family |
| C12orf57 protein network | https://string-db.org/network/9606.ENSP00000229281 | Protein C10; In brain, may be required for corpus callusum development; Belongs to the UPF0456 family |
| APOBEC1 protein network | https://string-db.org/network/9606.ENSP00000229304 | C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon [...] |
| NANOG protein network | https://string-db.org/network/9606.ENSP00000229307 | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their diffe [...] |
| GOLT1B protein network | https://string-db.org/network/9606.ENSP00000229314 | Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex |
| PRKAB1 protein network | https://string-db.org/network/9606.ENSP00000229328 | 5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy m [...] |
| CMAS protein network | https://string-db.org/network/9606.ENSP00000229329 | N-acylneuraminate cytidylyltransferase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for th [...] |
| HCFC2 protein network | https://string-db.org/network/9606.ENSP00000229330 | Host cell factor C2 |
| CLEC4A protein network | https://string-db.org/network/9606.ENSP00000229332 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via [...] |
| AICDA protein network | https://string-db.org/network/9606.ENSP00000229335 | Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lympho [...] |
| RAB35 protein network | https://string-db.org/network/9606.ENSP00000229340 | Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| COX6A1 protein network | https://string-db.org/network/9606.ENSP00000229379 | Cytochrome c oxidase subunit 6A1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| SRSF9 protein network | https://string-db.org/network/9606.ENSP00000229390 | Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10; Belongs to th [...] |
| FGFR1OP2 protein network | https://string-db.org/network/9606.ENSP00000229395 | FGFR1 oncogene partner 2; May be involved in wound healing pathway; Belongs to the SIKE family |
| KLRB1 protein network | https://string-db.org/network/9606.ENSP00000229402 | Killer cell lectin-like receptor subfamily B member 1; Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation w [...] |
| GCLC protein network | https://string-db.org/network/9606.ENSP00000229416 | Glutamate-cysteine ligase catalytic subunit |
| IYD protein network | https://string-db.org/network/9606.ENSP00000229447 | Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodi [...] |
| RSPH4A protein network | https://string-db.org/network/9606.ENSP00000229554 | Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head. Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin st [...] |
| ADTRP protein network | https://string-db.org/network/9606.ENSP00000229583 | Androgen-dependent TFPI-regulating protein; Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) |
| ASF1A protein network | https://string-db.org/network/9606.ENSP00000229595 | Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly fact [...] |
| HINT3 protein network | https://string-db.org/network/9606.ENSP00000229633 | Histidine triad nucleotide-binding protein 3; Hydrolyzes phosphoramidate and acyl-adenylate substrates; Belongs to the HINT family |
| ULBP1 protein network | https://string-db.org/network/9606.ENSP00000229708 | UL16-binding protein 1; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family |
| SLC44A4 protein network | https://string-db.org/network/9606.ENSP00000229729 | Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundl [...] |
| FBXO5 protein network | https://string-db.org/network/9606.ENSP00000229758 | F-box only protein 5; Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC acti [...] |
| FANCE protein network | https://string-db.org/network/9606.ENSP00000229769 | Fanconi anemia group E protein; As part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. Required for the nuclear accumulation of FANCC and provides a critical bridge betwe [...] |
| TULP1 protein network | https://string-db.org/network/9606.ENSP00000229771 | Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with c [...] |
| MAPK14 protein network | https://string-db.org/network/9606.ENSP00000229795 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an [...] |
| STK38 protein network | https://string-db.org/network/9606.ENSP00000229812 | Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K [...] |
| HLA-DOA protein network | https://string-db.org/network/9606.ENSP00000229829 | HLA class II histocompatibility antigen, DO alpha chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifi [...] |
| SAYSD1 protein network | https://string-db.org/network/9606.ENSP00000229903 | SAYSVFN motif domain containing 1 |
| CAP2 protein network | https://string-db.org/network/9606.ENSP00000229922 | Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family |
| GPR63 protein network | https://string-db.org/network/9606.ENSP00000229955 | Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans |
| GPLD1 protein network | https://string-db.org/network/9606.ENSP00000230036 | Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these [...] |
| ACOT13 protein network | https://string-db.org/network/9606.ENSP00000230048 | Acyl-coenzyme A thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to [...] |
| RPS12 protein network | https://string-db.org/network/9606.ENSP00000230050 | Ribosomal protein S12 |
| B3GAT2 protein network | https://string-db.org/network/9606.ENSP00000230053 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins; Beta-1,3-glucuronyltransf [...] |
| GMNN protein network | https://string-db.org/network/9606.ENSP00000230056 | Geminin; Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction [...] |
| SNX3 protein network | https://string-db.org/network/9606.ENSP00000230085 | Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol [...] |
| ZBTB24 protein network | https://string-db.org/network/9606.ENSP00000230122 | Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription; BTB domain containing |
| FIG4 protein network | https://string-db.org/network/9606.ENSP00000230124 | Polyphosphoinositide phosphatase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all thr [...] |
| UNC93A protein network | https://string-db.org/network/9606.ENSP00000230256 | Unc-93 homolog A; Belongs to the unc-93 family |
| C6orf118 protein network | https://string-db.org/network/9606.ENSP00000230301 | Uncharacterized protein C6orf118; Chromosome 6 open reading frame 118 |
| MDFI protein network | https://string-db.org/network/9606.ENSP00000230321 | MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in th [...] |
| BYSL protein network | https://string-db.org/network/9606.ENSP00000230340 | Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of huma [...] |
| GUCA1B protein network | https://string-db.org/network/9606.ENSP00000230361 | Guanylyl cyclase-activating protein 2; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. T [...] |
| PRPH2 protein network | https://string-db.org/network/9606.ENSP00000230381 | Peripherin-2; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morp [...] |
| DNPH1 protein network | https://string-db.org/network/9606.ENSP00000230431 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5- phosphate and a purine or pyrimidin [...] |
| EXOC2 protein network | https://string-db.org/network/9606.ENSP00000230449 | Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC5 family |
| TMEM30A protein network | https://string-db.org/network/9606.ENSP00000230461 | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inne [...] |
| LAMA4 protein network | https://string-db.org/network/9606.ENSP00000230538 | Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| PRSS16 protein network | https://string-db.org/network/9606.ENSP00000230582 | Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family |
| MEP1A protein network | https://string-db.org/network/9606.ENSP00000230588 | Meprin A subunit alpha; Belongs to the peptidase M12A family |
| SKIV2L2 protein network | https://string-db.org/network/9606.ENSP00000230640 | Superkiller viralicidic activity 2-like 2; Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-codin [...] |
| ISL1 protein network | https://string-db.org/network/9606.ENSP00000230658 | Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamen [...] |
| SLC6A7 protein network | https://string-db.org/network/9606.ENSP00000230671 | Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium-dependent reuptake into presynaptic terminals; Solute carriers |
| POU4F3 protein network | https://string-db.org/network/9606.ENSP00000230732 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of i [...] |
| HARS2 protein network | https://string-db.org/network/9606.ENSP00000230771 | Probable histidine--tRNA ligase, mitochondrial; histidyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class II |
| NUDT12 protein network | https://string-db.org/network/9606.ENSP00000230792 | Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine tripho [...] |
| PAPD7 protein network | https://string-db.org/network/9606.ENSP00000230859 | Non-canonical poly(A) RNA polymerase PAPD7; Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechan [...] |
| DAP protein network | https://string-db.org/network/9606.ENSP00000230895 | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death |
| HBEGF protein network | https://string-db.org/network/9606.ENSP00000230990 | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smoot [...] |
| LOX protein network | https://string-db.org/network/9606.ENSP00000231004 | Protein-lysine 6-oxidase; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May [...] |
| GZMK protein network | https://string-db.org/network/9606.ENSP00000231009 | Granzyme K; Belongs to the peptidase S1 family. Granzyme subfamily |
| CDH9 protein network | https://string-db.org/network/9606.ENSP00000231021 | Cadherin-9; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| SPARC protein network | https://string-db.org/network/9606.ENSP00000231061 | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cel [...] |
| HAND1 protein network | https://string-db.org/network/9606.ENSP00000231121 | Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adu [...] |
| PCDHB3 protein network | https://string-db.org/network/9606.ENSP00000231130 | Protocadherin beta-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| PCDHB5 protein network | https://string-db.org/network/9606.ENSP00000231134 | Protocadherin beta-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| PCDHB6 protein network | https://string-db.org/network/9606.ENSP00000231136 | Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of speci [...] |
| PCDHB7 protein network | https://string-db.org/network/9606.ENSP00000231137 | Protocadherin beta-7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| PCDHB15 protein network | https://string-db.org/network/9606.ENSP00000231173 | Protocadherin beta-15; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| GRM6 protein network | https://string-db.org/network/9606.ENSP00000231188 | Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| THG1L protein network | https://string-db.org/network/9606.ENSP00000231198 | Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidel [...] |
| IL12B protein network | https://string-db.org/network/9606.ENSP00000231228 | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated killer cells, and stimulate the producti [...] |
| TTC1 protein network | https://string-db.org/network/9606.ENSP00000231238 | Tetratricopeptide repeat domain containing |
| LNPEP protein network | https://string-db.org/network/9606.ENSP00000231368 | Leucyl-cystinyl aminopeptidase; Release of an N-terminal amino acid, cleaves before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and ang [...] |
| AGXT2 protein network | https://string-db.org/network/9606.ENSP00000231420 | Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is [...] |
| IL4 protein network | https://string-db.org/network/9606.ENSP00000231449 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecu [...] |
| IL5 protein network | https://string-db.org/network/9606.ENSP00000231454 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells; Belongs to the IL-5 family |
| ST8SIA4 protein network | https://string-db.org/network/9606.ENSP00000231461 | CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on t [...] |
| PCDH12 protein network | https://string-db.org/network/9606.ENSP00000231484 | Protocadherin-12; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium-dependent aggregation and adhesion [...] |
| SKP1 protein network | https://string-db.org/network/9606.ENSP00000231487 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progre [...] |
| NUP155 protein network | https://string-db.org/network/9606.ENSP00000231498 | Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins [...] |
| NR3C1 protein network | https://string-db.org/network/9606.ENSP00000231509 | Glucocorticoid receptor; Isoform Alpha-D3: Has lowest transcriptional activation activity of all isoforms created by alternative initiation. Has transcriptional repression activity; Nuclear hormo [...] |
| C5orf15 protein network | https://string-db.org/network/9606.ENSP00000231512 | Keratinocyte-associated transmembrane protein 2; Chromosome 5 open reading frame 15 |
| TRIM23 protein network | https://string-db.org/network/9606.ENSP00000231524 | E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination [...] |
| RARS protein network | https://string-db.org/network/9606.ENSP00000231572 | Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion [...] |
| CDX1 protein network | https://string-db.org/network/9606.ENSP00000231656 | Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 pr [...] |
| BNIP1 protein network | https://string-db.org/network/9606.ENSP00000231668 | BCL2/adenovirus E1B 19kDa interacting protein 1; BCL2 homology region 3 only |
| SLC7A14 protein network | https://string-db.org/network/9606.ENSP00000231706 | Probable cationic amino acid transporter; May be involved in arginine transport; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A. [...] |
| SEMA3G protein network | https://string-db.org/network/9606.ENSP00000231721 | Semaphorin-3G; Has chemorepulsive activities for sympathetic axons. Ligand of NRP2 (By similarity); Immunoglobulin like domain containing |
| ZMYND10 protein network | https://string-db.org/network/9606.ENSP00000231749 | Zinc finger MYND domain-containing protein 10; Required for motile ciliary function. Probably involved in axonemal assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper a [...] |
| LTF protein network | https://string-db.org/network/9606.ENSP00000231751 | Lactotransferrin; Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of prefere [...] |
| MLH1 protein network | https://string-db.org/network/9606.ENSP00000231790 | DNA mismatch repair protein Mlh1; Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-M [...] |
| EHHADH protein network | https://string-db.org/network/9606.ENSP00000231887 | Peroxisomal bifunctional enzyme; enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family |
| CRBN protein network | https://string-db.org/network/9606.ENSP00000231948 | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, [...] |
| HRG protein network | https://string-db.org/network/9606.ENSP00000232003 | Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and hep [...] |
| UBE3A protein network | https://string-db.org/network/9606.ENSP00000232165 | Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several su [...] |
| RBP2 protein network | https://string-db.org/network/9606.ENSP00000232217 | Retinol-binding protein 2; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family |
| RBP1 protein network | https://string-db.org/network/9606.ENSP00000232219 | Retinol-binding protein 1; Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis; Belo [...] |
| PFKFB4 protein network | https://string-db.org/network/9606.ENSP00000232375 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family |
| HES1 protein network | https://string-db.org/network/9606.ENSP00000232424 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MY [...] |
| GNAT1 protein network | https://string-db.org/network/9606.ENSP00000232461 | Guanine nucleotide-binding protein G(t) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Tra [...] |
| TUSC2 protein network | https://string-db.org/network/9606.ENSP00000232496 | Tumor suppressor candidate 2; May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cel [...] |
| NPRL2 protein network | https://string-db.org/network/9606.ENSP00000232501 | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrol [...] |
| GNB4 protein network | https://string-db.org/network/9606.ENSP00000232564 | Guanine nucleotide-binding protein subunit beta-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta [...] |
| MORC1 protein network | https://string-db.org/network/9606.ENSP00000232603 | MORC family CW-type zinc finger protein 1; Required for spermatogenesis; Zinc fingers CW-type |
| UMPS protein network | https://string-db.org/network/9606.ENSP00000232607 | Uridine 5'-monophosphate synthase; Uridine monophosphate synthetase; In the C-terminal section; belongs to the OMP decarboxylase family |
| ABTB1 protein network | https://string-db.org/network/9606.ENSP00000232744 | Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes; Ankyrin repeat domain c [...] |
| KLHL18 protein network | https://string-db.org/network/9606.ENSP00000232766 | Kelch-like protein 18; Kelch like family member 18; BTB domain containing |
| RRP9 protein network | https://string-db.org/network/9606.ENSP00000232888 | U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal [...] |
| AADAC protein network | https://string-db.org/network/9606.ENSP00000232892 | Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stor [...] |
| EIF1B protein network | https://string-db.org/network/9606.ENSP00000232905 | Eukaryotic translation initiation factor 1b; Probably involved in translation |
| ZBTB47 protein network | https://string-db.org/network/9606.ENSP00000232974 | Zinc finger and BTB domain-containing protein 47; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TNNC1 protein network | https://string-db.org/network/9606.ENSP00000232975 | Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosi [...] |
| NKTR protein network | https://string-db.org/network/9606.ENSP00000232978 | NK-tumor recognition protein; Component of a putative tumor-recognition complex. Involved in the function of NK cells; Cyclophilin peptidylprolyl isomerases |
| NEK4 protein network | https://string-db.org/network/9606.ENSP00000233027 | Serine/threonine-protein kinase Nek4; Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited num [...] |
| TMEM159 protein network | https://string-db.org/network/9606.ENSP00000233047 | Promethin; Transmembrane protein 159; Belongs to the TMEM159 family |
| WDFY1 protein network | https://string-db.org/network/9606.ENSP00000233055 | WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand [...] |
| EIF2AK2 protein network | https://string-db.org/network/9606.ENSP00000233057 | Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infecti [...] |
| DAZAP1 protein network | https://string-db.org/network/9606.ENSP00000233078 | DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis |
| HEATR5B protein network | https://string-db.org/network/9606.ENSP00000233099 | HEAT repeat-containing protein 5B; Armadillo-like helical domain containing |
| MAPRE3 protein network | https://string-db.org/network/9606.ENSP00000233121 | Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Prom [...] |
| TMSB10 protein network | https://string-db.org/network/9606.ENSP00000233143 | Thymosin beta-10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Be [...] |
| MSH2 protein network | https://string-db.org/network/9606.ENSP00000233146 | DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2- MSH6 heterodimer) and MutS beta (MSH2-MSH [...] |
| NCK2 protein network | https://string-db.org/network/9606.ENSP00000233154 | Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by pr [...] |
| TFPI protein network | https://string-db.org/network/9606.ENSP00000233156 | Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It [...] |
| SLC11A1 protein network | https://string-db.org/network/9606.ENSP00000233202 | Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-spe [...] |
| APOB protein network | https://string-db.org/network/9606.ENSP00000233242 | Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellula [...] |
| INO80B protein network | https://string-db.org/network/9606.ENSP00000233331 | INO80 complex subunit B; Induces growth and cell cycle arrests at the G1 phase of the cell cycle; INO80 complex |
| TTL protein network | https://string-db.org/network/9606.ENSP00000233336 | Tubulin--tyrosine ligase; Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin |
| FAHD2A protein network | https://string-db.org/network/9606.ENSP00000233379 | Fumarylacetoacetate hydrolase domain-containing protein 2A; May have hydrolase activity |
| SF3B6 protein network | https://string-db.org/network/9606.ENSP00000233468 | Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| SLC30A3 protein network | https://string-db.org/network/9606.ENSP00000233535 | Zinc transporter 3; Involved in accumulation of zinc in synaptic vesicles; Solute carriers |
| NRBP1 protein network | https://string-db.org/network/9606.ENSP00000233557 | Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the N [...] |
| SNX17 protein network | https://string-db.org/network/9606.ENSP00000233575 | Sorting nexin-17; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. P [...] |
| REEP6 protein network | https://string-db.org/network/9606.ENSP00000233596 | Receptor accessory protein 6 |
| WBP1 protein network | https://string-db.org/network/9606.ENSP00000233615 | WW domain binding protein 1; WBP1/VOPP1 family |
| MOGS protein network | https://string-db.org/network/9606.ENSP00000233616 | Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner; Belongs to the glyc [...] |
| TTC31 protein network | https://string-db.org/network/9606.ENSP00000233623 | Tetratricopeptide repeat domain containing |
| NDUFS7 protein network | https://string-db.org/network/9606.ENSP00000233627 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...] |
| PCGF1 protein network | https://string-db.org/network/9606.ENSP00000233630 | Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as [...] |
| TLX2 protein network | https://string-db.org/network/9606.ENSP00000233638 | T-cell leukemia homeobox protein 2; Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of ent [...] |
| DOK1 protein network | https://string-db.org/network/9606.ENSP00000233668 | Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be [...] |
| ACADL protein network | https://string-db.org/network/9606.ENSP00000233710 | Long-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-CoA dehydrogenase long chain; Belongs to the acyl-CoA dehydrogenase family |
| EVA1A protein network | https://string-db.org/network/9606.ENSP00000233712 | Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis |
| REG1A protein network | https://string-db.org/network/9606.ENSP00000233735 | Lithostathine-1-alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration; C-ty [...] |
| IGFBP2 protein network | https://string-db.org/network/9606.ENSP00000233809 | Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or [...] |
| IGFBP5 protein network | https://string-db.org/network/9606.ENSP00000233813 | Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...] |
| KCNJ13 protein network | https://string-db.org/network/9606.ENSP00000233826 | Inward rectifier potassium channel 13; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...] |
| GGCX protein network | https://string-db.org/network/9606.ENSP00000233838 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversio [...] |
| NEU2 protein network | https://string-db.org/network/9606.ENSP00000233840 | Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides |
| HSPE1 protein network | https://string-db.org/network/9606.ENSP00000233893 | 10 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported pr [...] |
| WNT6 protein network | https://string-db.org/network/9606.ENSP00000233948 | Protein Wnt-6; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete re [...] |
| IL1RL1 protein network | https://string-db.org/network/9606.ENSP00000233954 | Interleukin-1 receptor-like 1; Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by p [...] |
| SLC9A2 protein network | https://string-db.org/network/9606.ENSP00000233969 | Sodium/hydrogen exchanger 2; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| AZU1 protein network | https://string-db.org/network/9606.ENSP00000233997 | Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gr [...] |
| PPP1R7 protein network | https://string-db.org/network/9606.ENSP00000234038 | Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family |
| PROC protein network | https://string-db.org/network/9606.ENSP00000234071 | Vitamin K-dependent protein C; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospho [...] |
| ID2 protein network | https://string-db.org/network/9606.ENSP00000234091 | DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...] |
| ODC1 protein network | https://string-db.org/network/9606.ENSP00000234111 | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and sp [...] |
| GORASP2 protein network | https://string-db.org/network/9606.ENSP00000234160 | Golgi reassembly-stacking protein 2; Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regula [...] |
| CEBPZ protein network | https://string-db.org/network/9606.ENSP00000234170 | CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Armadillo-like helical domain containing |
| RMDN2 protein network | https://string-db.org/network/9606.ENSP00000234195 | Regulator of microtubule dynamics 2; Belongs to the RMDN family |
| DLX2 protein network | https://string-db.org/network/9606.ENSP00000234198 | Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play [...] |
| SLC1A4 protein network | https://string-db.org/network/9606.ENSP00000234256 | Neutral amino acid transporter A; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence; Solute carriers |
| ORC2 protein network | https://string-db.org/network/9606.ENSP00000234296 | Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...] |
| PPP3R1 protein network | https://string-db.org/network/9606.ENSP00000234310 | Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity; EF-hand domain containing |
| PLEK protein network | https://string-db.org/network/9606.ENSP00000234313 | Pleckstrin; Major protein kinase C substrate of platelets; Pleckstrin homology domain containing |
| PRTN3 protein network | https://string-db.org/network/9606.ENSP00000234347 | Myeloblastin; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances end [...] |
| KISS1R protein network | https://string-db.org/network/9606.ENSP00000234371 | KiSS-1 receptor; Receptor for metastin (kisspeptin-54 or kp-54), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein that suppresses metastases in malignant melano [...] |
| GRIN3B protein network | https://string-db.org/network/9606.ENSP00000234389 | Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivi [...] |
| VAX2 protein network | https://string-db.org/network/9606.ENSP00000234392 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression [...] |
| ATP6V1B1 protein network | https://string-db.org/network/9606.ENSP00000234396 | V-type proton ATPase subunit B, kidney isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartmen [...] |
| MSH6 protein network | https://string-db.org/network/9606.ENSP00000234420 | DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiatin [...] |
| PLEKHA3 protein network | https://string-db.org/network/9606.ENSP00000234453 | Pleckstrin homology domain-containing family A member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate [...] |
| SPR protein network | https://string-db.org/network/9606.ENSP00000234454 | Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin; Belongs to the sepiapterin reductase family |
| CLCN6 protein network | https://string-db.org/network/9606.ENSP00000234488 | Chloride transport protein 6; Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is function [...] |
| ENO1 protein network | https://string-db.org/network/9606.ENSP00000234590 | Alpha-enolase; Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also functio [...] |
| SARS protein network | https://string-db.org/network/9606.ENSP00000234677 | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser- AMP and then transferred to the acceptor en [...] |
| CLCA1 protein network | https://string-db.org/network/9606.ENSP00000234701 | Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cysti [...] |
| BCL9 protein network | https://string-db.org/network/9606.ENSP00000234739 | B-cell CLL/lymphoma 9 protein; Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity); Belongs to the BCL9 family |
| TPSG1 protein network | https://string-db.org/network/9606.ENSP00000234798 | Tryptase gamma; Serine proteases |
| ANGPTL1 protein network | https://string-db.org/network/9606.ENSP00000234816 | Angiopoietin-related protein 1; Fibrinogen C domain containing; Angiopoietin like |
| TCEANC2 protein network | https://string-db.org/network/9606.ENSP00000234827 | Transcription elongation factor A N-terminal and central domain containing 2 |
| TMEM59 protein network | https://string-db.org/network/9606.ENSP00000234831 | Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, lea [...] |
| OPRD1 protein network | https://string-db.org/network/9606.ENSP00000234961 | Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that tr [...] |
| WDR77 protein network | https://string-db.org/network/9606.ENSP00000235090 | Methylosome protein 50; Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins a [...] |
| C1orf21 protein network | https://string-db.org/network/9606.ENSP00000235307 | Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21 |
| MAD2L2 protein network | https://string-db.org/network/9606.ENSP00000235310 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the er [...] |
| MFN2 protein network | https://string-db.org/network/9606.ENSP00000235329 | Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibri [...] |
| MIIP protein network | https://string-db.org/network/9606.ENSP00000235332 | Migration and invasion-inhibitory protein; Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 o [...] |
| SLC35D1 protein network | https://string-db.org/network/9606.ENSP00000235345 | UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic retic [...] |
| PRAMEF10 protein network | https://string-db.org/network/9606.ENSP00000235347 | PRAME family member 10; Belongs to the PRAME family |
| PRAMEF4 protein network | https://string-db.org/network/9606.ENSP00000235349 | PRAME family member 4; Belongs to the PRAME family |
| PRDM2 protein network | https://string-db.org/network/9606.ENSP00000235372 | PR domain zinc finger protein 2; S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor [...] |
| RGS2 protein network | https://string-db.org/network/9606.ENSP00000235382 | Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...] |
| WARS2 protein network | https://string-db.org/network/9606.ENSP00000235521 | Tryptophan--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial gen [...] |
| OSCP1 protein network | https://string-db.org/network/9606.ENSP00000235532 | Protein OSCP1; May be involved in drug clearance in the placenta |
| NT5C1A protein network | https://string-db.org/network/9606.ENSP00000235628 | Cytosolic 5'-nucleotidase 1A; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ische [...] |
| AKR7A2 protein network | https://string-db.org/network/9606.ENSP00000235835 | Aflatoxin B1 aldehyde reductase member 2; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gam [...] |
| CD160 protein network | https://string-db.org/network/9606.ENSP00000235933 | CD160 antigen; Receptor showing broad specificity for both classical and non-classical MHC class I molecules |
| LEPRE1 protein network | https://string-db.org/network/9606.ENSP00000236040 | Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in [...] |
| SLC19A2 protein network | https://string-db.org/network/9606.ENSP00000236137 | Thiamine transporter 1; High-affinity transporter for the intake of thiamine; Solute carriers |
| SELL protein network | https://string-db.org/network/9606.ENSP00000236147 | L-selectin; Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling [...] |
| FMO6P protein network | https://string-db.org/network/9606.ENSP00000236166 | Putative dimethylaniline monooxygenase [N-oxide-forming] 6; It is probable that this protein is only produced in very small quantity or not at all as the gene coding for it seems to be unable to [...] |
| VAMP4 protein network | https://string-db.org/network/9606.ENSP00000236192 | Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory [...] |
| SYF2 protein network | https://string-db.org/network/9606.ENSP00000236273 | Pre-mRNA-splicing factor SYF2; May be involved in pre-mRNA splicing; Belongs to the SYF2 family |
| SLC5A9 protein network | https://string-db.org/network/9606.ENSP00000236495 | Sodium/glucose cotransporter 4; Involved in sodium-dependent transport of D-mannose, D- glucose and D-fructose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family |
| CTSD protein network | https://string-db.org/network/9606.ENSP00000236671 | Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pa [...] |
| A4GNT protein network | https://string-db.org/network/9606.ENSP00000236709 | Alpha-1,4-N-acetylglucosaminyltransferase; Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically [...] |
| MMP8 protein network | https://string-db.org/network/9606.ENSP00000236826 | Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens; Belongs to the peptidase M10A family |
| APOA1 protein network | https://string-db.org/network/9606.ENSP00000236850 | Apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the l [...] |
| SLC8A2 protein network | https://string-db.org/network/9606.ENSP00000236877 | Sodium/calcium exchanger 2; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca [...] |
| TNNT2 protein network | https://string-db.org/network/9606.ENSP00000236918 | Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase [...] |
| CAMSAP2 protein network | https://string-db.org/network/9606.ENSP00000236925 | Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...] |
| ATIC protein network | https://string-db.org/network/9606.ENSP00000236959 | Bifunctional purine biosynthesis protein PURH; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family |
| TNP1 protein network | https://string-db.org/network/9606.ENSP00000236979 | Spermatid nuclear transition protein 1; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes [...] |
| FASTKD2 protein network | https://string-db.org/network/9606.ENSP00000236980 | FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit; FASTK mitochondrial RNA binding family |
| TTR protein network | https://string-db.org/network/9606.ENSP00000237014 | Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain; Gla domain containing |
| DOPEY1 protein network | https://string-db.org/network/9606.ENSP00000237163 | Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes |
| FILIP1 protein network | https://string-db.org/network/9606.ENSP00000237172 | Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation o [...] |
| SPACA1 protein network | https://string-db.org/network/9606.ENSP00000237201 | Sperm acrosome membrane-associated protein 1; May be involved in sperm-egg fusion |
| TBPL1 protein network | https://string-db.org/network/9606.ENSP00000237264 | TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter [...] |
| ZC2HC1B protein network | https://string-db.org/network/9606.ENSP00000237275 | Zinc finger C2HC-type containing 1B; Belongs to the ZC2HC1 family |
| FBXO30 protein network | https://string-db.org/network/9606.ENSP00000237281 | F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation; F-boxes other |
| ADAT2 protein network | https://string-db.org/network/9606.ENSP00000237283 | tRNA-specific adenosine deaminase 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily |
| PMFBP1 protein network | https://string-db.org/network/9606.ENSP00000237353 | Polyamine-modulated factor 1-binding protein 1; May play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization o [...] |
| MED28 protein network | https://string-db.org/network/9606.ENSP00000237380 | Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| RNF103 protein network | https://string-db.org/network/9606.ENSP00000237455 | E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway; Ring finger proteins |
| RPN2 protein network | https://string-db.org/network/9606.ENSP00000237530 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligos [...] |
| SOGA1 protein network | https://string-db.org/network/9606.ENSP00000237536 | Protein SOGA1; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner; Belongs to the SOGA family |
| PKD2 protein network | https://string-db.org/network/9606.ENSP00000237596 | Polycystin-2; Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable [...] |
| ABCG2 protein network | https://string-db.org/network/9606.ENSP00000237612 | ATP-binding cassette sub-family G member 2; High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates [...] |
| STBD1 protein network | https://string-db.org/network/9606.ENSP00000237642 | Starch-binding domain-containing protein 1; Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosom [...] |
| CCNI protein network | https://string-db.org/network/9606.ENSP00000237654 | Cyclin-I; Cyclin I; Belongs to the cyclin family |
| RARRES1 protein network | https://string-db.org/network/9606.ENSP00000237696 | Retinoic acid receptor responder protein 1; Inhibitor of the cytoplasmic carboxypeptidase AGBL2, may regulate the alpha-tubulin tyrosination cycle |
| C2orf43 protein network | https://string-db.org/network/9606.ENSP00000237822 | Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote c [...] |
| FGF23 protein network | https://string-db.org/network/9606.ENSP00000237837 | Fibroblast growth factor 23; Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By simil [...] |
| ELL2 protein network | https://string-db.org/network/9606.ENSP00000237853 | RNA polymerase II elongation factor ELL2; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription b [...] |
| NDUFB3 protein network | https://string-db.org/network/9606.ENSP00000237889 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| ZFAND5 protein network | https://string-db.org/network/9606.ENSP00000237937 | AN1-type zinc finger protein 5; Involved in protein degradation via the ubiquitin- proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-medi [...] |
| GDA protein network | https://string-db.org/network/9606.ENSP00000238018 | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family |
| C2orf40 protein network | https://string-db.org/network/9606.ENSP00000238044 | Augurin; Probable hormone that may induce senescence of oligodendrocyte and neural precursor cells, characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal d [...] |
| CPSF3 protein network | https://string-db.org/network/9606.ENSP00000238112 | Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...] |
| DDX55 protein network | https://string-db.org/network/9606.ENSP00000238146 | ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase; DEAD-box helicases |
| CCDC92 protein network | https://string-db.org/network/9606.ENSP00000238156 | Coiled-coil domain containing 92 |
| FKBP15 protein network | https://string-db.org/network/9606.ENSP00000238256 | FK506-binding protein 15; May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes [...] |
| HDHD3 protein network | https://string-db.org/network/9606.ENSP00000238379 | Haloacid dehalogenase like hydrolase domain containing 3 |
| VPS4B protein network | https://string-db.org/network/9606.ENSP00000238497 | Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes thei [...] |
| SERPINB10 protein network | https://string-db.org/network/9606.ENSP00000238508 | Serpin B10; Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm a [...] |
| GSC protein network | https://string-db.org/network/9606.ENSP00000238558 | Homeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, [...] |
| ADCK1 protein network | https://string-db.org/network/9606.ENSP00000238561 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosp [...] |
| IFI27L2 protein network | https://string-db.org/network/9606.ENSP00000238609 | Interferon alpha inducible protein 27 like 2 |
| NEK9 protein network | https://string-db.org/network/9606.ENSP00000238616 | Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, [...] |
| ACYP1 protein network | https://string-db.org/network/9606.ENSP00000238618 | Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family |
| IFT43 protein network | https://string-db.org/network/9606.ENSP00000238628 | Intraflagellar transport proteins |
| IRF2BPL protein network | https://string-db.org/network/9606.ENSP00000238647 | Interferon regulatory factor 2-binding protein-like; May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 [...] |
| ACOT2 protein network | https://string-db.org/network/9606.ENSP00000238651 | Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...] |
| FLVCR2 protein network | https://string-db.org/network/9606.ENSP00000238667 | Feline leukemia virus subgroup C receptor-related protein 2; Acts as an importer of heme. Also acts as a transporter for a calcium-chelator complex, important for growth and calcium metabolism; S [...] |
| TGFB3 protein network | https://string-db.org/network/9606.ENSP00000238682 | Transforming growth factor beta-3; Involved in embryogenesis and cell differentiation; Belongs to the TGF-beta family |
| PAPOLG protein network | https://string-db.org/network/9606.ENSP00000238714 | Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclea [...] |
| TP53I3 protein network | https://string-db.org/network/9606.ENSP00000238721 | Quinone oxidoreductase PIG3; May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-nap [...] |
| RHOQ protein network | https://string-db.org/network/9606.ENSP00000238738 | Rho-related GTP-binding protein RhoQ; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effec [...] |
| TMEM214 protein network | https://string-db.org/network/9606.ENSP00000238788 | Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum str [...] |
| ATAD2B protein network | https://string-db.org/network/9606.ENSP00000238789 | ATPase family, AAA domain containing 2B |
| FAM98A protein network | https://string-db.org/network/9606.ENSP00000238823 | Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation. Involved in skeletal homeostasis (By similarity). Positively regulates lysosome peripheral distribution and ruffl [...] |
| YIPF4 protein network | https://string-db.org/network/9606.ENSP00000238831 | Protein YIPF4; Involved in the maintenance of the Golgi structure; Belongs to the YIP1 family |
| AFTPH protein network | https://string-db.org/network/9606.ENSP00000238855 | Aftiphilin; May play a role in membrane trafficking |
| LGALSL protein network | https://string-db.org/network/9606.ENSP00000238875 | Galectin-related protein; Does not bind lactose, and may not bind carbohydrates |
| CRIPT protein network | https://string-db.org/network/9606.ENSP00000238892 | Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses |
| TMEM180 protein network | https://string-db.org/network/9606.ENSP00000238936 | Transmembrane protein 180 |
| PPP1R3C protein network | https://string-db.org/network/9606.ENSP00000238994 | Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limi [...] |
| PRLHR protein network | https://string-db.org/network/9606.ENSP00000239032 | Prolactin-releasing peptide receptor; Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing; Belongs to the G-protein coup [...] |
| HOXB8 protein network | https://string-db.org/network/9606.ENSP00000239144 | Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| HOXB5 protein network | https://string-db.org/network/9606.ENSP00000239151 | Homeobox protein Hox-B5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| HOXB7 protein network | https://string-db.org/network/9606.ENSP00000239165 | Homeobox protein Hox-B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| DUSP1 protein network | https://string-db.org/network/9606.ENSP00000239223 | Dual specificity protein phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell c [...] |
| PANK3 protein network | https://string-db.org/network/9606.ENSP00000239231 | Pantothenate kinase 3; Plays a role in the physiological regulation of the intracellular CoA concentration |
| MSX2 protein network | https://string-db.org/network/9606.ENSP00000239243 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during oste [...] |
| INSL4 protein network | https://string-db.org/network/9606.ENSP00000239316 | Early placenta insulin-like peptide; May play an important role in trophoblast development and in the regulation of bone formation; Belongs to the insulin family |
| IFNA7 protein network | https://string-db.org/network/9606.ENSP00000239347 | Interferon alpha-7; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfero [...] |
| LRP11 protein network | https://string-db.org/network/9606.ENSP00000239367 | Low-density lipoprotein receptor-related protein 11; Low density lipoprotein receptors; Belongs to the LDLR family |
| CCDC170 protein network | https://string-db.org/network/9606.ENSP00000239374 | Coiled-coil domain containing 170 |
| ARAP3 protein network | https://string-db.org/network/9606.ENSP00000239440 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeli [...] |
| PCDHB8 protein network | https://string-db.org/network/9606.ENSP00000239444 | Protocadherin beta-8; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of speci [...] |
| PCDHB10 protein network | https://string-db.org/network/9606.ENSP00000239446 | Protocadherin beta-10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| PCDHB14 protein network | https://string-db.org/network/9606.ENSP00000239449 | Protocadherin beta-14; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| PCDHB12 protein network | https://string-db.org/network/9606.ENSP00000239450 | Protocadherin beta-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| SLC25A2 protein network | https://string-db.org/network/9606.ENSP00000239451 | Mitochondrial ornithine transporter 2; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| PRRX1 protein network | https://string-db.org/network/9606.ENSP00000239461 | Paired mesoderm homeobox protein 1; Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein bind [...] |
| TNN protein network | https://string-db.org/network/9606.ENSP00000239462 | Tenascin-N; Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity). Involved in neurite outgrowth and cell migration in hippocampal ex [...] |
| TTLL2 protein network | https://string-db.org/network/9606.ENSP00000239587 | Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin [...] |
| MSANTD2 protein network | https://string-db.org/network/9606.ENSP00000239614 | Myb/SANT-like DNA-binding domain-containing protein 2; Myb/SANT DNA binding domain containing 2 |
| PDZD11 protein network | https://string-db.org/network/9606.ENSP00000239666 | Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33 |
| NUDCD1 protein network | https://string-db.org/network/9606.ENSP00000239690 | NudC domain containing 1 |
| CCDC77 protein network | https://string-db.org/network/9606.ENSP00000239830 | Coiled-coil domain containing 77 |
| ELF1 protein network | https://string-db.org/network/9606.ENSP00000239882 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expre [...] |
| ALG5 protein network | https://string-db.org/network/9606.ENSP00000239891 | ALG5, dolichyl-phosphate beta-glucosyltransferase; Glycosyltransferase family 2 |
| FAM53C protein network | https://string-db.org/network/9606.ENSP00000239906 | Protein FAM53C; Family with sequence similarity 53 member C |
| MYOT protein network | https://string-db.org/network/9606.ENSP00000239926 | Myotilin; Component of a complex of multiple actin cross-linking proteins. Involved in the control of myofibril assembly and stability at the Z lines in muscle cells; I-set domain containing |
| EGR1 protein network | https://string-db.org/network/9606.ENSP00000239938 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds do [...] |
| PFN2 protein network | https://string-db.org/network/9606.ENSP00000239940 | Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By b [...] |
| NFYB protein network | https://string-db.org/network/9606.ENSP00000240055 | Nuclear transcription factor Y subunit beta; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the prom [...] |
| CCDC53 protein network | https://string-db.org/network/9606.ENSP00000240079 | WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...] |
| DUSP4 protein network | https://string-db.org/network/9606.ENSP00000240100 | Dual specificity protein phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2 |
| SORBS3 protein network | https://string-db.org/network/9606.ENSP00000240123 | Vinexin; Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to E [...] |
| TARDBP protein network | https://string-db.org/network/9606.ENSP00000240185 | TAR DNA-binding protein 43; DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the [...] |
| PRAMEF2 protein network | https://string-db.org/network/9606.ENSP00000240189 | PRAME family member 2; Belongs to the PRAME family |
| RDH10 protein network | https://string-db.org/network/9606.ENSP00000240285 | Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol [...] |
| DLX4 protein network | https://string-db.org/network/9606.ENSP00000240306 | Homeobox protein DLX-4; May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis; Belongs to the distal-l [...] |
| COIL protein network | https://string-db.org/network/9606.ENSP00000240316 | Coilin; Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs; Belongs to the coilin family |
| TBX2 protein network | https://string-db.org/network/9606.ENSP00000240328 | T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative reg [...] |
| SLC35B1 protein network | https://string-db.org/network/9606.ENSP00000240333 | Solute carrier family 35 member B1; Probable sugar transporter; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily |
| TBX4 protein network | https://string-db.org/network/9606.ENSP00000240335 | T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation; T-boxes |
| TEX14 protein network | https://string-db.org/network/9606.ENSP00000240361 | Inactive serine/threonine-protein kinase TEX14; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular br [...] |
| FAM117A protein network | https://string-db.org/network/9606.ENSP00000240364 | Protein FAM117A; Family with sequence similarity 117 member A |
| NCAPH protein network | https://string-db.org/network/9606.ENSP00000240423 | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...] |
| MND1 protein network | https://string-db.org/network/9606.ENSP00000240488 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis (By similarity). Stimulates both [...] |
| ZNF141 protein network | https://string-db.org/network/9606.ENSP00000240499 | Zinc finger protein 141; May be involved in transcriptional regulation as a repressor. Plays a role in limb development; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TSHZ3 protein network | https://string-db.org/network/9606.ENSP00000240587 | Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expre [...] |
| TAS2R8 protein network | https://string-db.org/network/9606.ENSP00000240615 | Taste receptor type 2 member 8; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| PLBD1 protein network | https://string-db.org/network/9606.ENSP00000240617 | Phospholipase B-like 1; In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase [...] |
| KLRK1 protein network | https://string-db.org/network/9606.ENSP00000240618 | Killer cell lectin-like receptor subfamily K, member 1; Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligan [...] |
| TAS2R10 protein network | https://string-db.org/network/9606.ENSP00000240619 | Taste receptor type 2 member 10; Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 an [...] |
| PYROXD1 protein network | https://string-db.org/network/9606.ENSP00000240651 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Involved in cellular response to oxidative stress; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase fa [...] |
| IAPP protein network | https://string-db.org/network/9606.ENSP00000240652 | Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calciton [...] |
| KCNJ8 protein network | https://string-db.org/network/9606.ENSP00000240662 | ATP-sensitive inward rectifier potassium channel 8; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potass [...] |
| TAS2R7 protein network | https://string-db.org/network/9606.ENSP00000240687 | Taste receptor type 2 member 7; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...] |
| TAS2R9 protein network | https://string-db.org/network/9606.ENSP00000240691 | Taste receptor type 2 member 9; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...] |
| TFG protein network | https://string-db.org/network/9606.ENSP00000240851 | Protein TFG; Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules |
| KALRN protein network | https://string-db.org/network/9606.ENSP00000240874 | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, thr [...] |
| NAA50 protein network | https://string-db.org/network/9606.ENSP00000240922 | N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate th [...] |
| MAPK8IP1 protein network | https://string-db.org/network/9606.ENSP00000241014 | C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...] |
| PEX16 protein network | https://string-db.org/network/9606.ENSP00000241041 | Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and P [...] |
| DEPDC7 protein network | https://string-db.org/network/9606.ENSP00000241051 | DEP domain containing 7; Belongs to the DEPDC7 family |
| CAT protein network | https://string-db.org/network/9606.ENSP00000241052 | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloi [...] |
| GJA3 protein network | https://string-db.org/network/9606.ENSP00000241125 | Gap junction alpha-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| GHSR protein network | https://string-db.org/network/9606.ENSP00000241256 | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) ( [...] |
| TNFSF10 protein network | https://string-db.org/network/9606.ENSP00000241261 | Tumor necrosis factor ligand superfamily member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces a [...] |
| CPXM2 protein network | https://string-db.org/network/9606.ENSP00000241305 | Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions; M14 carboxypeptidases |
| GSTM2 protein network | https://string-db.org/network/9606.ENSP00000241337 | Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family |
| ACVR2A protein network | https://string-db.org/network/9606.ENSP00000241416 | Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate [...] |
| POLK protein network | https://string-db.org/network/9606.ENSP00000241436 | DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA s [...] |
| FLT3 protein network | https://string-db.org/network/9606.ENSP00000241453 | Receptor-type tyrosine-protein kinase FLT3; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematop [...] |
| RASL11A protein network | https://string-db.org/network/9606.ENSP00000241463 | Ras-like protein family member 11A; Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription (By similarity); Belongs to the small GTP [...] |
| FYTTD1 protein network | https://string-db.org/network/9606.ENSP00000241502 | UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to [...] |
| MYOG protein network | https://string-db.org/network/9606.ENSP00000241651 | Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential [...] |
| AHR protein network | https://string-db.org/network/9606.ENSP00000242057 | Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemi [...] |
| BBS9 protein network | https://string-db.org/network/9606.ENSP00000242067 | Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis [...] |
| OCM protein network | https://string-db.org/network/9606.ENSP00000242104 | Oncomodulin-1; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions; EF-hand domain containing |
| EEPD1 protein network | https://string-db.org/network/9606.ENSP00000242108 | Endonuclease/exonuclease/phosphatase family domain containing 1 |
| WIPF3 protein network | https://string-db.org/network/9606.ENSP00000242140 | WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization. May have a role in spermatogenesis (By similarity); Belongs to the verprolin family |
| HOXA7 protein network | https://string-db.org/network/9606.ENSP00000242159 | Homeobox protein Hox-A7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| INHBA protein network | https://string-db.org/network/9606.ENSP00000242208 | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...] |
| RAMP3 protein network | https://string-db.org/network/9606.ENSP00000242249 | Receptor activity-modifying protein 3; Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-relat [...] |
| FTSJ2 protein network | https://string-db.org/network/9606.ENSP00000242257 | rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methyluridine at position 1369 (Um1369) in the 16S m [...] |
| TWIST1 protein network | https://string-db.org/network/9606.ENSP00000242261 | Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through phy [...] |
| CLTA protein network | https://string-db.org/network/9606.ENSP00000242285 | Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabili [...] |
| KIAA1045 protein network | https://string-db.org/network/9606.ENSP00000242315 | PHD finger protein 24; KIAA1045 |
| ZC3HAV1 protein network | https://string-db.org/network/9606.ENSP00000242351 | Zinc finger CCCH-type antiviral protein 1; Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to [...] |
| AKR1D1 protein network | https://string-db.org/network/9606.ENSP00000242375 | 3-oxo-5-beta-steroid 4-dehydrogenase; Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile a [...] |
| NEUROG3 protein network | https://string-db.org/network/9606.ENSP00000242462 | Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a commo [...] |
| SRGN protein network | https://string-db.org/network/9606.ENSP00000242465 | Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tis [...] |
| EGR2 protein network | https://string-db.org/network/9606.ENSP00000242480 | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4; Belongs to the EGR C2H2-type zinc-finger [...] |
| FAM149B1 protein network | https://string-db.org/network/9606.ENSP00000242505 | Protein FAM149B1; Family with sequence similarity 149 member B1 |
| UNG protein network | https://string-db.org/network/9606.ENSP00000242576 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the u [...] |
| IFT81 protein network | https://string-db.org/network/9606.ENSP00000242591 | Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of [...] |
| ACADS protein network | https://string-db.org/network/9606.ENSP00000242592 | Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Introduces a double bond at position 2 in saturated acyl-CoA's of short chain length, i.e. less than 6 carbon atoms; Belongs to the acy [...] |
| RNF11 protein network | https://string-db.org/network/9606.ENSP00000242719 | RING finger protein 11; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways [...] |
| BHLHE41 protein network | https://string-db.org/network/9606.ENSP00000242728 | Class E basic helix-loop-helix protein 41; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controll [...] |
| SSPN protein network | https://string-db.org/network/9606.ENSP00000242729 | Sarcospan; Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. [...] |
| DDX39A protein network | https://string-db.org/network/9606.ENSP00000242776 | ATP-dependent RNA helicase DDX39A; Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus; Belongs to the DEAD box helicase family. DECD subfamily |
| C19orf43 protein network | https://string-db.org/network/9606.ENSP00000242784 | Telomerase RNA component interacting RNase; Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end [...] |
| CD97 protein network | https://string-db.org/network/9606.ENSP00000242786 | CD97 antigen; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity); Belongs to t [...] |
| ZNF442 protein network | https://string-db.org/network/9606.ENSP00000242804 | Zinc finger protein 442; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CCDC70 protein network | https://string-db.org/network/9606.ENSP00000242819 | Coiled-coil domain containing 70 |
| EBPL protein network | https://string-db.org/network/9606.ENSP00000242827 | Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands |
| ATP7B protein network | https://string-db.org/network/9606.ENSP00000242839 | Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile; ATPase copper transportin [...] |
| NEUROD4 protein network | https://string-db.org/network/9606.ENSP00000242994 | Neurogenic differentiation factor 4; Probably acts as a transcriptional activator. Mediates neuronal differentiation. Required for the regulation of amacrine cell fate specification in the retina [...] |
| ORMDL2 protein network | https://string-db.org/network/9606.ENSP00000243045 | ORM1-like protein 2; Negative regulator of sphingolipid synthesis |
| PDE1B protein network | https://string-db.org/network/9606.ENSP00000243052 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regu [...] |
| HOXC13 protein network | https://string-db.org/network/9606.ENSP00000243056 | Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity); Belongs to th [...] |
| LRP1 protein network | https://string-db.org/network/9606.ENSP00000243077 | Prolow-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cel [...] |
| HOXC12 protein network | https://string-db.org/network/9606.ENSP00000243103 | Homeobox protein Hox-C12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| HOXC6 protein network | https://string-db.org/network/9606.ENSP00000243108 | Homeobox protein Hox-C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| FAAH protein network | https://string-db.org/network/9606.ENSP00000243167 | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to termin [...] |
| RSRP1 protein network | https://string-db.org/network/9606.ENSP00000243189 | Arginine and serine rich protein 1; Belongs to the RSRP family |
| SEC61A1 protein network | https://string-db.org/network/9606.ENSP00000243253 | Protein transport protein Sec61 subunit alpha isoform 1; Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory [...] |
| RAB9B protein network | https://string-db.org/network/9606.ENSP00000243298 | Ras-related protein Rab-9B; Involved in the transport of proteins between the endosomes and the trans Golgi network; Belongs to the small GTPase superfamily. Rab family |
| ENSG00000123584 protein network | https://string-db.org/network/9606.ENSP00000243314 | Melanoma antigen family A, 9B; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family |
| RIF1 protein network | https://string-db.org/network/9606.ENSP00000243326 | Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end j [...] |
| TTC21B protein network | https://string-db.org/network/9606.ENSP00000243344 | Tetratricopeptide repeat protein 21B; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Negatively modulates the SHH signal transduction (By similarity) [...] |
| NMI protein network | https://string-db.org/network/9606.ENSP00000243346 | N-myc-interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/ [...] |
| TNFAIP6 protein network | https://string-db.org/network/9606.ENSP00000243347 | Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis |
| ACVR1C protein network | https://string-db.org/network/9606.ENSP00000243349 | Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonin [...] |
| SLC36A1 protein network | https://string-db.org/network/9606.ENSP00000243389 | Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Beside [...] |
| BATF3 protein network | https://string-db.org/network/9606.ENSP00000243440 | Basic leucine zipper transcriptional factor ATF-like 3; AP-1 family transcription factor that controls the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Requ [...] |
| KCNJ2 protein network | https://string-db.org/network/9606.ENSP00000243457 | Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are char [...] |
| PLA2G12A protein network | https://string-db.org/network/9606.ENSP00000243501 | Group XIIA secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoy [...] |
| SNRPA protein network | https://string-db.org/network/9606.ENSP00000243563 | U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 [...] |
| B9D2 protein network | https://string-db.org/network/9606.ENSP00000243578 | B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...] |
| C4BPB protein network | https://string-db.org/network/9606.ENSP00000243611 | C4b-binding protein beta chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. [...] |
| ZNF350 protein network | https://string-db.org/network/9606.ENSP00000243644 | Zinc finger protein 350; Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3; Zinc fingers C2H2-type |
| RAB38 protein network | https://string-db.org/network/9606.ENSP00000243662 | Ras-related protein Rab-38; May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; [...] |
| GPR83 protein network | https://string-db.org/network/9606.ENSP00000243673 | Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor; G protein-coupled receptors, Class A orphans |
| HAUS3 protein network | https://string-db.org/network/9606.ENSP00000243706 | HAUS augmin-like complex subunit 3; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| CHPF protein network | https://string-db.org/network/9606.ENSP00000243776 | Chondroitin sulfate synthase 2; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...] |
| INHA protein network | https://string-db.org/network/9606.ENSP00000243786 | Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of divers [...] |
| ENKD1 protein network | https://string-db.org/network/9606.ENSP00000243878 | Enkurin domain containing 1 |
| ACTR5 protein network | https://string-db.org/network/9606.ENSP00000243903 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DN [...] |
| MC3R protein network | https://string-db.org/network/9606.ENSP00000243911 | Melanocortin receptor 3; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patte [...] |
| SYS1 protein network | https://string-db.org/network/9606.ENSP00000243918 | Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1; Belongs to the SYS1 family |
| PI3 protein network | https://string-db.org/network/9606.ENSP00000243924 | Elafin; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis; WAP four-disulfide core domain containing |
| WFDC3 protein network | https://string-db.org/network/9606.ENSP00000243938 | WAP four-disulfide core domain containing |
| ATP5E protein network | https://string-db.org/network/9606.ENSP00000243997 | ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membran [...] |
| PLCG1 protein network | https://string-db.org/network/9606.ENSP00000244007 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an [...] |
| SRSF6 protein network | https://string-db.org/network/9606.ENSP00000244020 | Serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10 [...] |
| RAB22A protein network | https://string-db.org/network/9606.ENSP00000244040 | Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF-mediated end [...] |
| PTGIS protein network | https://string-db.org/network/9606.ENSP00000244043 | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Cytochrome P450 family 8 |
| SNAI1 protein network | https://string-db.org/network/9606.ENSP00000244050 | Zinc finger protein SNAI1; Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Bi [...] |
| MOCS3 protein network | https://string-db.org/network/9606.ENSP00000244051 | Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential durin [...] |
| RNF114 protein network | https://string-db.org/network/9606.ENSP00000244061 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stim [...] |
| MAGEA10 protein network | https://string-db.org/network/9606.ENSP00000244096 | Melanoma-associated antigen 10; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family |
| PEPD protein network | https://string-db.org/network/9606.ENSP00000244137 | Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in co [...] |
| IL9R protein network | https://string-db.org/network/9606.ENSP00000244174 | Interleukin-9 receptor; This is a receptor for interleukin-9; Belongs to the type I cytokine receptor family. Type 4 subfamily |
| MCEE protein network | https://string-db.org/network/9606.ENSP00000244217 | Methylmalonyl-CoA epimerase, mitochondrial; methylmalonyl-CoA epimerase; Belongs to the glyoxalase I family |
| PAIP2B protein network | https://string-db.org/network/9606.ENSP00000244221 | Polyadenylate-binding protein-interacting protein 2B; Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail; Belongs to the PAIP2 family |
| SNRNP27 protein network | https://string-db.org/network/9606.ENSP00000244227 | U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein; May play a role in mRNA splicing |
| MPHOSPH10 protein network | https://string-db.org/network/9606.ENSP00000244230 | U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA process [...] |
| IL17C protein network | https://string-db.org/network/9606.ENSP00000244241 | Interleukin-17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibac [...] |
| LIPE protein network | https://string-db.org/network/9606.ENSP00000244289 | Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters [...] |
| IRGC protein network | https://string-db.org/network/9606.ENSP00000244314 | Interferon-inducible GTPase 5; Immunity related GTPase cinema |
| LYPD3 protein network | https://string-db.org/network/9606.ENSP00000244333 | Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression; LY6/PLAUR domain containing |
| CEACAM8 protein network | https://string-db.org/network/9606.ENSP00000244336 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| RNF39 protein network | https://string-db.org/network/9606.ENSP00000244360 | RING finger protein 39; May play a role in prolonged long term-potentiation (LTP) maintenance; Ring finger proteins |
| FBXO9 protein network | https://string-db.org/network/9606.ENSP00000244426 | F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...] |
| RRP36 protein network | https://string-db.org/network/9606.ENSP00000244496 | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family |
| BTN1A1 protein network | https://string-db.org/network/9606.ENSP00000244513 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the api [...] |
| BTN3A3 protein network | https://string-db.org/network/9606.ENSP00000244519 | Butyrophilin subfamily 3 member A3; Plays a role in T-cell responses in the adaptive immune response; Belongs to the immunoglobulin superfamily. BTN/MOG family |
| SNRPC protein network | https://string-db.org/network/9606.ENSP00000244520 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNR [...] |
| SLC17A1 protein network | https://string-db.org/network/9606.ENSP00000244527 | Sodium-dependent phosphate transport protein 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the [...] |
| HIST1H1D protein network | https://string-db.org/network/9606.ENSP00000244534 | Histone H1.3; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...] |
| HIST1H4F protein network | https://string-db.org/network/9606.ENSP00000244537 | Histone cluster 1 H4 family member f; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| UNC5CL protein network | https://string-db.org/network/9606.ENSP00000244565 | UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF-kappa-B binding to its targets; Belongs to the unc-5 family |
| AARS2 protein network | https://string-db.org/network/9606.ENSP00000244571 | Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the accept [...] |
| HIST1H1A protein network | https://string-db.org/network/9606.ENSP00000244573 | Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...] |
| ZNF391 protein network | https://string-db.org/network/9606.ENSP00000244576 | Zinc finger protein 391; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR2B6 protein network | https://string-db.org/network/9606.ENSP00000244623 | Olfactory receptor 2B6; Odorant receptor; Olfactory receptors, family 2 |
| APOBEC2 protein network | https://string-db.org/network/9606.ENSP00000244669 | C->U-editing enzyme APOBEC-2; Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase [...] |
| TREM1 protein network | https://string-db.org/network/9606.ENSP00000244709 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as inc [...] |
| MEA1 protein network | https://string-db.org/network/9606.ENSP00000244711 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development |
| COL21A1 protein network | https://string-db.org/network/9606.ENSP00000244728 | Collagen type XXI alpha 1 chain; Collagens |
| SOX4 protein network | https://string-db.org/network/9606.ENSP00000244745 | Transcription factor SOX-4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif; SRY-boxes |
| CPNE5 protein network | https://string-db.org/network/9606.ENSP00000244751 | Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocyt [...] |
| SSR1 protein network | https://string-db.org/network/9606.ENSP00000244763 | Translocon-associated protein subunit alpha; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. M [...] |
| ATXN1 protein network | https://string-db.org/network/9606.ENSP00000244769 | Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along wit [...] |
| EREG protein network | https://string-db.org/network/9606.ENSP00000244869 | Proepiregulin; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation. Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by r [...] |
| SCGB1D2 protein network | https://string-db.org/network/9606.ENSP00000244926 | Secretoglobin family 1D member 2; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of [...] |
| SCGB2A1 protein network | https://string-db.org/network/9606.ENSP00000244930 | Mammaglobin-B; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones; B [...] |
| EMC3 protein network | https://string-db.org/network/9606.ENSP00000245046 | ER membrane protein complex subunit 3 |
| SH3TC1 protein network | https://string-db.org/network/9606.ENSP00000245105 | SH3 domain and tetratricopeptide repeats 1 |
| KATNAL2 protein network | https://string-db.org/network/9606.ENSP00000245121 | Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays; AAA ATPases |
| BBS2 protein network | https://string-db.org/network/9606.ENSP00000245157 | Bardet-Biedl syndrome 2 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...] |
| MT2A protein network | https://string-db.org/network/9606.ENSP00000245185 | Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoid [...] |
| GOT2 protein network | https://string-db.org/network/9606.ENSP00000245206 | Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metab [...] |
| SPHK2 protein network | https://string-db.org/network/9606.ENSP00000245222 | Sphingosine kinase 2; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- di [...] |
| PIWIL1 protein network | https://string-db.org/network/9606.ENSP00000245255 | Piwi-like protein 1; Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline [...] |
| RAP2A protein network | https://string-db.org/network/9606.ENSP00000245304 | Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors inc [...] |
| SLC10A2 protein network | https://string-db.org/network/9606.ENSP00000245312 | Ileal sodium/bile acid cotransporter; Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism; B [...] |
| EFNB2 protein network | https://string-db.org/network/9606.ENSP00000245323 | Ephrin-B2; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithel [...] |
| SLC22A5 protein network | https://string-db.org/network/9606.ENSP00000245407 | Solute carrier family 22 member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of c [...] |
| IRF1 protein network | https://string-db.org/network/9606.ENSP00000245414 | Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-ind [...] |
| BMP4 protein network | https://string-db.org/network/9606.ENSP00000245451 | Bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stim [...] |
| PTGER2 protein network | https://string-db.org/network/9606.ENSP00000245457 | Prostaglandin E2 receptor EP2 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in i [...] |
| SOX9 protein network | https://string-db.org/network/9606.ENSP00000245479 | Transcription factor SOX-9; Transcriptional regulator. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (By similarity). Plays a role in chondrocyte [...] |
| MYH2 protein network | https://string-db.org/network/9606.ENSP00000245503 | Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity); Myosin heavy chains |
| MRPS7 protein network | https://string-db.org/network/9606.ENSP00000245539 | Mitochondrial ribosomal protein S7; Belongs to the universal ribosomal protein uS7 family |
| ARMC7 protein network | https://string-db.org/network/9606.ENSP00000245543 | Armadillo repeat containing 7 |
| NUP85 protein network | https://string-db.org/network/9606.ENSP00000245544 | Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex play [...] |
| NT5C protein network | https://string-db.org/network/9606.ENSP00000245552 | 5'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and l [...] |
| MSTO1 protein network | https://string-db.org/network/9606.ENSP00000245564 | Protein misato homolog 1; Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation; Belongs to the misato fam [...] |
| MBOAT7 protein network | https://string-db.org/network/9606.ENSP00000245615 | Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion [...] |
| LILRB3 protein network | https://string-db.org/network/9606.ENSP00000245620 | Leukocyte immunoglobulin-like receptor subfamily B member 3; May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the [...] |
| SLC35F5 protein network | https://string-db.org/network/9606.ENSP00000245680 | Solute carrier family 35 member F5; Putative solute transporter; Belongs to the SLC35F solute transporter family |
| INSIG2 protein network | https://string-db.org/network/9606.ENSP00000245787 | Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding protein [...] |
| PSD4 protein network | https://string-db.org/network/9606.ENSP00000245796 | PH and SEC7 domain-containing protein 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the [...] |
| PSPN protein network | https://string-db.org/network/9606.ENSP00000245810 | Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons; GDNF family ligands |
| ALKBH7 protein network | https://string-db.org/network/9606.ENSP00000245812 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due [...] |
| CLPP protein network | https://string-db.org/network/9606.ENSP00000245816 | ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase acti [...] |
| TNFSF9 protein network | https://string-db.org/network/9606.ENSP00000245817 | Tumor necrosis factor ligand superfamily member 9; Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell deat [...] |
| THOC2 protein network | https://string-db.org/network/9606.ENSP00000245838 | THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcript [...] |
| CD70 protein network | https://string-db.org/network/9606.ENSP00000245903 | CD70 antigen; Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells; Belongs to the tu [...] |
| C3 protein network | https://string-db.org/network/9606.ENSP00000245907 | Complement C3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. A [...] |
| SH2D3A protein network | https://string-db.org/network/9606.ENSP00000245908 | SH2 domain-containing protein 3A; May play a role in JNK activation; NSP adaptor proteins |
| FOSB protein network | https://string-db.org/network/9606.ENSP00000245919 | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity; Belongs to the bZIP family. Fos subfamily |
| RTN2 protein network | https://string-db.org/network/9606.ENSP00000245923 | Reticulon-2; Reticulon 2 |
| VASP protein network | https://string-db.org/network/9606.ENSP00000245932 | Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidanc [...] |
| SYMPK protein network | https://string-db.org/network/9606.ENSP00000245934 | Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might n [...] |
| CFAP61 protein network | https://string-db.org/network/9606.ENSP00000245957 | Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; Cilia and flagella associated |
| CDC25B protein network | https://string-db.org/network/9606.ENSP00000245960 | M-phase inducer phosphatase 2; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscis [...] |
| GNRH2 protein network | https://string-db.org/network/9606.ENSP00000245983 | Progonadoliberin-2; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family |
| CD93 protein network | https://string-db.org/network/9606.ENSP00000246006 | Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement [...] |
| CST8 protein network | https://string-db.org/network/9606.ENSP00000246012 | Cystatin-8; Performs a specialized role during sperm development and maturation; Cystatins, type 2 |
| TMX4 protein network | https://string-db.org/network/9606.ENSP00000246024 | Thioredoxin related transmembrane protein 4; Protein disulfide isomerases |
| MKKS protein network | https://string-db.org/network/9606.ENSP00000246062 | McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex plays a role in the [...] |
| DSTN protein network | https://string-db.org/network/9606.ENSP00000246069 | Destrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner |
| LAMP5 protein network | https://string-db.org/network/9606.ENSP00000246070 | Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain |
| SNRPB2 protein network | https://string-db.org/network/9606.ENSP00000246071 | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A' protein; RNA binding [...] |
| TCF15 protein network | https://string-db.org/network/9606.ENSP00000246080 | Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm; Basic [...] |
| OTOR protein network | https://string-db.org/network/9606.ENSP00000246081 | Otoraplin; MIA family; Belongs to the MIA/OTOR family |
| SCRT2 protein network | https://string-db.org/network/9606.ENSP00000246104 | Transcriptional repressor scratch 2; May be involved in transcriptional regulation; SNAG transcriptional repressors |
| DEFB129 protein network | https://string-db.org/network/9606.ENSP00000246105 | Beta-defensin 129; Has antibacterial activity; Defensins, beta |
| TLE6 protein network | https://string-db.org/network/9606.ENSP00000246112 | Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to t [...] |
| S1PR4 protein network | https://string-db.org/network/9606.ENSP00000246115 | Sphingosine 1-phosphate receptor 4; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types o [...] |
| NCLN protein network | https://string-db.org/network/9606.ENSP00000246117 | Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning; Belongs to the nicastrin family |
| PITHD1 protein network | https://string-db.org/network/9606.ENSP00000246151 | Promotes megakaryocyte differentiation by up-regulating RUNX1 expression . Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activi [...] |
| FNTB protein network | https://string-db.org/network/9606.ENSP00000246166 | Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth p [...] |
| MMP24 protein network | https://string-db.org/network/9606.ENSP00000246186 | Matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cel [...] |
| NECAB3 protein network | https://string-db.org/network/9606.ENSP00000246190 | N-terminal EF-hand calcium-binding protein 3; Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid- beta. May enhance the activity of [...] |
| RALY protein network | https://string-db.org/network/9606.ENSP00000246194 | RNA-binding protein Raly; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is requi [...] |
| PLAGL2 protein network | https://string-db.org/network/9606.ENSP00000246229 | Zinc finger protein PLAGL2; Shows weak transcriptional activatory activity; Zinc fingers C2H2-type |
| UROD protein network | https://string-db.org/network/9606.ENSP00000246337 | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III |
| SLC35E2 protein network | https://string-db.org/network/9606.ENSP00000246421 | Solute carrier family 35 member E2; Putative transporter; Solute carriers |
| SLURP1 protein network | https://string-db.org/network/9606.ENSP00000246515 | Secreted Ly-6/uPAR-related protein 1; Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity [...] |
| IGFLR1 protein network | https://string-db.org/network/9606.ENSP00000246532 | IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2 |
| CAPNS1 protein network | https://string-db.org/network/9606.ENSP00000246533 | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal [...] |
| PDCD2L protein network | https://string-db.org/network/9606.ENSP00000246535 | Programmed cell death protein 2-like; Over-expression suppresses AP1, CREB, NFAT, and NF-kB transcriptional activation, and delays cell cycle progression at S phase |
| UBA2 protein network | https://string-db.org/network/9606.ENSP00000246548 | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of [...] |
| HCST protein network | https://string-db.org/network/9606.ENSP00000246551 | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a majo [...] |
| FFAR1 protein network | https://string-db.org/network/9606.ENSP00000246553 | Free fatty acid receptor 1; G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding incr [...] |
| COX6B1 protein network | https://string-db.org/network/9606.ENSP00000246554 | Cytochrome c oxidase subunit 6B1; Connects the two COX monomers into the physiological dimeric form; Mitochondrial complex IV: cytochrome c oxidase subunits |
| KRT13 protein network | https://string-db.org/network/9606.ENSP00000246635 | Keratin, type I cytoskeletal 13; Keratins, type I |
| KRT38 protein network | https://string-db.org/network/9606.ENSP00000246646 | Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family |
| CCR7 protein network | https://string-db.org/network/9606.ENSP00000246657 | C-C chemokine receptor type 7; Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions; Belongs to the G-protein coupled recepto [...] |
| KRT9 protein network | https://string-db.org/network/9606.ENSP00000246662 | Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Play [...] |
| NR1D1 protein network | https://string-db.org/network/9606.ENSP00000246672 | Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex tr [...] |
| ARL2 protein network | https://string-db.org/network/9606.ENSP00000246747 | ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleoti [...] |
| RRAS protein network | https://string-db.org/network/9606.ENSP00000246792 | Ras-related protein R-Ras; Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity; Belongs to the small GTPase superfamily. Ras family |
| PRRG2 protein network | https://string-db.org/network/9606.ENSP00000246794 | Transmembrane gamma-carboxyglutamic acid protein 2; Proline rich and Gla domain containing |
| TSKS protein network | https://string-db.org/network/9606.ENSP00000246801 | Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development; Protein phosphatase 1 regulatory subun [...] |
| GLTSCR2 protein network | https://string-db.org/network/9606.ENSP00000246802 | Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may al [...] |
| FLRT1 protein network | https://string-db.org/network/9606.ENSP00000246841 | Leucine-rich repeat transmembrane protein FLRT1; Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FG [...] |
| SBDS protein network | https://string-db.org/network/9606.ENSP00000246868 | Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in [...] |
| CSN1S1 protein network | https://string-db.org/network/9606.ENSP00000246891 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate; Belongs to the alpha-casein family |
| STATH protein network | https://string-db.org/network/9606.ENSP00000246895 | Statherin; Salivary protein that stabilizes saliva supersaturated with calcium salts by inhibiting the precipitation of calcium phosphate salts. It also modulates hydroxyapatite crystal formation [...] |
| MLX protein network | https://string-db.org/network/9606.ENSP00000246912 | Max-like protein X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TC [...] |
| WNK4 protein network | https://string-db.org/network/9606.ENSP00000246914 | Serine/threonine-protein kinase WNK4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an ac [...] |
| TRAP1 protein network | https://string-db.org/network/9606.ENSP00000246957 | Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial compl [...] |
| SUGP1 protein network | https://string-db.org/network/9606.ENSP00000247001 | SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing; G-patch domain containing |
| DDX49 protein network | https://string-db.org/network/9606.ENSP00000247003 | Probable ATP-dependent RNA helicase DDX49; DEAD-box helicase 49; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily |
| GDF1 protein network | https://string-db.org/network/9606.ENSP00000247005 | Growth differentiation factor 1; May mediate cell differentiation events during embryonic development; Endogenous ligands |
| SDF2 protein network | https://string-db.org/network/9606.ENSP00000247020 | Stromal cell derived factor 2 |
| NSRP1 protein network | https://string-db.org/network/9606.ENSP00000247026 | Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation |
| CFP protein network | https://string-db.org/network/9606.ENSP00000247153 | Properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes |
| ATG14 protein network | https://string-db.org/network/9606.ENSP00000247178 | Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a r [...] |
| SIX1 protein network | https://string-db.org/network/9606.ENSP00000247182 | Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several or [...] |
| DLGAP5 protein network | https://string-db.org/network/9606.ENSP00000247191 | Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key [...] |
| L3HYPDH protein network | https://string-db.org/network/9606.ENSP00000247194 | Trans-3-hydroxy-L-proline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline fro [...] |
| TBPL2 protein network | https://string-db.org/network/9606.ENSP00000247219 | TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at [...] |
| SGPP1 protein network | https://string-db.org/network/9606.ENSP00000247225 | Sphingosine-1-phosphate phosphatase 1; Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1- phoshate, lysophosphatidic acid or phos [...] |
| PLEKHG3 protein network | https://string-db.org/network/9606.ENSP00000247226 | Pleckstrin homology and RhoGEF domain containing G3 |
| EVI2A protein network | https://string-db.org/network/9606.ENSP00000247270 | Protein EVI2A; May complex with itself or/and other proteins within the membrane, to function as part of a cell-surface receptor |
| OMG protein network | https://string-db.org/network/9606.ENSP00000247271 | Oligodendrocyte-myelin glycoprotein; Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system |
| CTAG2 protein network | https://string-db.org/network/9606.ENSP00000247306 | Belongs to the CTAG/PCC1 family |
| CANX protein network | https://string-db.org/network/9606.ENSP00000247461 | Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER [...] |
| PYCARD protein network | https://string-db.org/network/9606.ENSP00000247470 | Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also [...] |
| PHPT1 protein network | https://string-db.org/network/9606.ENSP00000247665 | 14 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity; Protein phosphatases |
| TRAF2 protein network | https://string-db.org/network/9606.ENSP00000247668 | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switch [...] |
| ABHD8 protein network | https://string-db.org/network/9606.ENSP00000247706 | Protein ABHD8; Abhydrolase domain containing 8; Belongs to the AB hydrolase superfamily |
| HELB protein network | https://string-db.org/network/9606.ENSP00000247815 | DNA helicase B; 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit [...] |
| YEATS4 protein network | https://string-db.org/network/9606.ENSP00000247843 | YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] |
| TAS2R3 protein network | https://string-db.org/network/9606.ENSP00000247879 | Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calciu [...] |
| TAS2R4 protein network | https://string-db.org/network/9606.ENSP00000247881 | Taste receptor type 2 member 4; Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestina [...] |
| TAS2R5 protein network | https://string-db.org/network/9606.ENSP00000247883 | Taste receptor type 2 member 5; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| ZNF777 protein network | https://string-db.org/network/9606.ENSP00000247930 | Zinc finger protein 777; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IDUA protein network | https://string-db.org/network/9606.ENSP00000247933 | Alpha-L-iduronidase; Iduronidase, alpha-L- |
| ZNF317 protein network | https://string-db.org/network/9606.ENSP00000247956 | Zinc finger protein 317; May function as a transcription factor. May play an important role in erythroid maturation and lymphoid proliferation; Zinc fingers C2H2-type |
| PIN1 protein network | https://string-db.org/network/9606.ENSP00000247970 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr- Pro) motifs. By in [...] |
| FBXL12 protein network | https://string-db.org/network/9606.ENSP00000247977 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of [...] |
| KIF17 protein network | https://string-db.org/network/9606.ENSP00000247986 | Kinesin-like protein KIF17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin famil [...] |
| PLA2G2C protein network | https://string-db.org/network/9606.ENSP00000247992 | Putative inactive group IIC secretory phospholipase A2; Inactive phospholipase; Phospholipases |
| OR7A10 protein network | https://string-db.org/network/9606.ENSP00000248058 | Olfactory receptor 7A10; Odorant receptor; Olfactory receptors, family 7 |
| KLF2 protein network | https://string-db.org/network/9606.ENSP00000248071 | Krueppel-like factor 2; Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription; Kruppel like factors |
| OR7C2 protein network | https://string-db.org/network/9606.ENSP00000248072 | Olfactory receptor 7C2; Odorant receptor; Olfactory receptors, family 7 |
| OR7C1 protein network | https://string-db.org/network/9606.ENSP00000248073 | Olfactory receptor 7C1; Odorant receptor; Olfactory receptors, family 7 |
| F2RL3 protein network | https://string-db.org/network/9606.ENSP00000248076 | Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to t [...] |
| HCFC1R1 protein network | https://string-db.org/network/9606.ENSP00000248089 | Host cell factor C1 regulator 1; Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated e [...] |
| HN1L protein network | https://string-db.org/network/9606.ENSP00000248098 | Jupiter microtubule associated homolog 2; Hematological and neurological expressed 1-like; Belongs to the JUPITER family |
| GFER protein network | https://string-db.org/network/9606.ENSP00000248114 | FAD-linked sulfhydryl oxidase ALR; Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formatio [...] |
| SYNGR3 protein network | https://string-db.org/network/9606.ENSP00000248121 | Synaptogyrin-3; May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from [...] |
| GNG13 protein network | https://string-db.org/network/9606.ENSP00000248150 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...] |
| ZNF10 protein network | https://string-db.org/network/9606.ENSP00000248211 | Zinc finger protein 10; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TICAM1 protein network | https://string-db.org/network/9606.ENSP00000248244 | TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3 and TLR4 (through TICAM2) to mediate NF- kappa-B and interferon-regulatory f [...] |
| MON1B protein network | https://string-db.org/network/9606.ENSP00000248248 | MON1 homolog B, secretory trafficking associated; Belongs to the MON1/SAND family |
| METTL25 protein network | https://string-db.org/network/9606.ENSP00000248306 | Methyltransferase-like protein 25; Putative methyltransferase |
| EIF3K protein network | https://string-db.org/network/9606.ENSP00000248342 | Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| OR1E2 protein network | https://string-db.org/network/9606.ENSP00000248384 | Olfactory receptor 1E2; Odorant receptor; Olfactory receptors, family 1 |
| TUBA4A protein network | https://string-db.org/network/9606.ENSP00000248437 | Tubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| VIL1 protein network | https://string-db.org/network/9606.ENSP00000248444 | Villin-1; Epithelial cell-specific Ca(2+)-regulated actin- modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament [...] |
| AAMP protein network | https://string-db.org/network/9606.ENSP00000248450 | Angio-associated migratory cell protein; Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway; WD repeat domain containing |
| HSPB1 protein network | https://string-db.org/network/9606.ENSP00000248553 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistan [...] |
| GNG11 protein network | https://string-db.org/network/9606.ENSP00000248564 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...] |
| GNGT1 protein network | https://string-db.org/network/9606.ENSP00000248572 | Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. Th [...] |
| PTPN12 protein network | https://string-db.org/network/9606.ENSP00000248594 | Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERB [...] |
| FGL2 protein network | https://string-db.org/network/9606.ENSP00000248598 | Fibroleukin; May play a role in physiologic lymphocyte functions at mucosal sites; Fibrinogen C domain containing |
| STYXL1 protein network | https://string-db.org/network/9606.ENSP00000248600 | Serine/threonine/tyrosine-interacting-like protein 1; Probable pseudophosphatase. Contains a Ser residue instead of a conserved Cys residue in the dsPTPase catalytic loop which probably renders i [...] |
| PEX1 protein network | https://string-db.org/network/9606.ENSP00000248633 | Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase co [...] |
| MTERF1 protein network | https://string-db.org/network/9606.ENSP00000248643 | Transcription termination factor 1, mitochondrial; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of [...] |
| LRFN1 protein network | https://string-db.org/network/9606.ENSP00000248668 | Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Ind [...] |
| RASL11B protein network | https://string-db.org/network/9606.ENSP00000248706 | Ras-like protein family member 11B; RAS like family 11 member B |
| TUBGCP6 protein network | https://string-db.org/network/9606.ENSP00000248846 | Gamma-tubulin complex component 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome |
| DGCR6L protein network | https://string-db.org/network/9606.ENSP00000248879 | Protein DGCR6L; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family |
| CYTH4 protein network | https://string-db.org/network/9606.ENSP00000248901 | Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP; Pleckstrin homology domain containing |
| SGSM3 protein network | https://string-db.org/network/9606.ENSP00000248929 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators |
| SEZ6L protein network | https://string-db.org/network/9606.ENSP00000248933 | Seizure 6-like protein; May contribute to specialized endoplasmic reticulum functions in neurons; Sushi domain containing |
| VPREB3 protein network | https://string-db.org/network/9606.ENSP00000248948 | Pre-B lymphocyte protein 3; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells; V-set domain containing |
| SDF2L1 protein network | https://string-db.org/network/9606.ENSP00000248958 | Stromal cell derived factor 2 like 1 |
| YWHAH protein network | https://string-db.org/network/9606.ENSP00000248975 | 14-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognitio [...] |
| C22orf24 protein network | https://string-db.org/network/9606.ENSP00000248984 | Uncharacterized protein C22orf24; Chromosome 22 open reading frame 24 |
| RFPL3 protein network | https://string-db.org/network/9606.ENSP00000249007 | Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins |
| CDC42EP1 protein network | https://string-db.org/network/9606.ENSP00000249014 | Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts; CDC42 effector proteins |
| MCHR1 protein network | https://string-db.org/network/9606.ENSP00000249016 | Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrol [...] |
| GALR3 protein network | https://string-db.org/network/9606.ENSP00000249041 | Galanin receptor type 3; Receptor for the hormone galanin. Receptor for the hormone spexin-1 |
| APOL5 protein network | https://string-db.org/network/9606.ENSP00000249044 | Apolipoprotein L5; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins |
| CCDC117 protein network | https://string-db.org/network/9606.ENSP00000249064 | Coiled-coil domain containing 117 |
| APOL2 protein network | https://string-db.org/network/9606.ENSP00000249066 | Apolipoprotein L2; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins |
| RAC2 protein network | https://string-db.org/network/9606.ENSP00000249071 | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of ef [...] |
| LIF protein network | https://string-db.org/network/9606.ENSP00000249075 | Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid [...] |
| C22orf23 protein network | https://string-db.org/network/9606.ENSP00000249079 | UPF0193 protein EVG1; Chromosome 22 open reading frame 23 |
| PMPCB protein network | https://string-db.org/network/9606.ENSP00000249269 | Mitochondrial-processing peptidase subunit beta; Cleaves presequences (transit peptides) from mitochondrial protein precursors; M16 metallopeptidases |
| TAS2R16 protein network | https://string-db.org/network/9606.ENSP00000249284 | Taste receptor type 2 member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calci [...] |
| LSM8 protein network | https://string-db.org/network/9606.ENSP00000249299 | U6 snRNA-associated Sm-like protein LSm8; Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome; Belongs to the snRNP Sm proteins family |
| VGF protein network | https://string-db.org/network/9606.ENSP00000249330 | Neurosecretory protein VGF; May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system; Granins |
| STRIP2 protein network | https://string-db.org/network/9606.ENSP00000249344 | Striatin-interacting protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Belongs to the STRIP family |
| DNAJB9 protein network | https://string-db.org/network/9606.ENSP00000249356 | DnaJ homolog subfamily B member 9; Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein; DNAJ heat shock proteins |
| LRRC4 protein network | https://string-db.org/network/9606.ENSP00000249363 | Leucine-rich repeat-containing protein 4; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pa [...] |
| SMO protein network | https://string-db.org/network/9606.ENSP00000249373 | Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its recepto [...] |
| OPN1SW protein network | https://string-db.org/network/9606.ENSP00000249389 | Short-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal; Belongs to the G-prote [...] |
| SIRT2 protein network | https://string-db.org/network/9606.ENSP00000249396 | NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcr [...] |
| MTX2 protein network | https://string-db.org/network/9606.ENSP00000249442 | Metaxin-2; Involved in transport of proteins into the mitochondrion |
| HOXD9 protein network | https://string-db.org/network/9606.ENSP00000249499 | Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| HOXD10 protein network | https://string-db.org/network/9606.ENSP00000249501 | Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| HOXD11 protein network | https://string-db.org/network/9606.ENSP00000249504 | Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| PIAS1 protein network | https://string-db.org/network/9606.ENSP00000249636 | E3 SUMO-protein ligase PIAS1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...] |
| SNAP23 protein network | https://string-db.org/network/9606.ENSP00000249647 | Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion; [...] |
| TMOD2 protein network | https://string-db.org/network/9606.ENSP00000249700 | Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...] |
| DLL4 protein network | https://string-db.org/network/9606.ENSP00000249749 | Delta-like protein 4; Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migra [...] |
| ALDH1A2 protein network | https://string-db.org/network/9606.ENSP00000249750 | Retinal dehydrogenase 2; Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde [...] |
| KNSTRN protein network | https://string-db.org/network/9606.ENSP00000249776 | Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase tra [...] |
| CLN6 protein network | https://string-db.org/network/9606.ENSP00000249806 | CLN6, transmembrane ER protein |
| ISLR protein network | https://string-db.org/network/9606.ENSP00000249842 | Immunoglobulin superfamily containing leucine rich repeat; I-set domain containing |
| THAP10 protein network | https://string-db.org/network/9606.ENSP00000249861 | THAP domain containing 10 |
| ACKR4 protein network | https://string-db.org/network/9606.ENSP00000249887 | Atypical chemokine receptor 4; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...] |
| MBD4 protein network | https://string-db.org/network/9606.ENSP00000249910 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethyl [...] |
| COPB1 protein network | https://string-db.org/network/9606.ENSP00000249923 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynth [...] |
| MYOD1 protein network | https://string-db.org/network/9606.ENSP00000250003 | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 an [...] |
| TPH1 protein network | https://string-db.org/network/9606.ENSP00000250018 | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family |
| FAM64A protein network | https://string-db.org/network/9606.ENSP00000250056 | Protein PIMREG; During mitosis, may play a role in the control of metaphase-to-anaphase transition |
| ZNF232 protein network | https://string-db.org/network/9606.ENSP00000250076 | Zinc finger protein 232; May be involved in transcriptional regulation; SCAN domain containing |
| CD68 protein network | https://string-db.org/network/9606.ENSP00000250092 | Macrosialin; Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tiss [...] |
| TXNDC17 protein network | https://string-db.org/network/9606.ENSP00000250101 | Thioredoxin domain-containing protein 17; Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze [...] |
| ATP1B2 protein network | https://string-db.org/network/9606.ENSP00000250111 | Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...] |
| FXR2 protein network | https://string-db.org/network/9606.ENSP00000250113 | Fragile X mental retardation syndrome-related protein 2; RNA-binding protein |
| MPDU1 protein network | https://string-db.org/network/9606.ENSP00000250124 | Mannose-P-dolichol utilization defect 1 protein; Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI ancho [...] |
| WISP1 protein network | https://string-db.org/network/9606.ENSP00000250160 | WNT1-inducible-signaling pathway protein 1; Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage [...] |
| QTRT1 protein network | https://string-db.org/network/9606.ENSP00000250237 | Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at p [...] |
| AP1M2 protein network | https://string-db.org/network/9606.ENSP00000250244 | AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate t [...] |
| CLEC11A protein network | https://string-db.org/network/9606.ENSP00000250340 | C-type lectin domain family 11 member A; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult [...] |
| KLK12 protein network | https://string-db.org/network/9606.ENSP00000250351 | Kallikrein-12; Kallikrein related peptidase 12; Belongs to the peptidase S1 family. Kallikrein subfamily |
| CMA1 protein network | https://string-db.org/network/9606.ENSP00000250378 | Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion |
| BCL2L2 protein network | https://string-db.org/network/9606.ENSP00000250405 | Bcl-2-like protein 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX; Belongs to the [...] |
| PARP2 protein network | https://string-db.org/network/9606.ENSP00000250416 | Poly [ADP-ribose] polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin archite [...] |
| FOXA1 protein network | https://string-db.org/network/9606.ENSP00000250448 | Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differenti [...] |
| EAPP protein network | https://string-db.org/network/9606.ENSP00000250454 | E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry [...] |
| EGLN3 protein network | https://string-db.org/network/9606.ENSP00000250457 | Egl nine homolog 3; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...] |
| NEDD8 protein network | https://string-db.org/network/9606.ENSP00000250495 | NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP [...] |
| DAD1 protein network | https://string-db.org/network/9606.ENSP00000250498 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oli [...] |
| CDO1 protein network | https://string-db.org/network/9606.ENSP00000250535 | Cysteine dioxygenase type 1; Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of c [...] |
| RAP1B protein network | https://string-db.org/network/9606.ENSP00000250559 | Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct [...] |
| AANAT protein network | https://string-db.org/network/9606.ENSP00000250615 | Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in [...] |
| ARHGEF6 protein network | https://string-db.org/network/9606.ENSP00000250617 | Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF); Pleckstrin homology domain containing |
| ART1 protein network | https://string-db.org/network/9606.ENSP00000250693 | GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R; CD molecules |
| CHRNA10 protein network | https://string-db.org/network/9606.ENSP00000250699 | Neuronal acetylcholine receptor subunit alpha-10; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation th [...] |
| DAZL protein network | https://string-db.org/network/9606.ENSP00000250863 | Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRN [...] |
| MAPK8IP3 protein network | https://string-db.org/network/9606.ENSP00000250894 | C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...] |
| MKNK2 protein network | https://string-db.org/network/9606.ENSP00000250896 | MAP kinase-interacting serine/threonine-protein kinase 2; Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress [...] |
| KLF16 protein network | https://string-db.org/network/9606.ENSP00000250916 | Krueppel-like factor 16; Transcription factor that binds GC and GT boxes and displaces Sp1 and Sp3 from these sequences. Modulates dopaminergic transmission in the brain (By similarity); Kruppel [...] |
| ABHD17A protein network | https://string-db.org/network/9606.ENSP00000250974 | Protein ABHD17A; Abhydrolase domain containing 17A |
| SALL1 protein network | https://string-db.org/network/9606.ENSP00000251020 | Sal-like protein 1; Transcriptional repressor involved in organogenesis; Zinc fingers C2H2-type |
| ZC3H14 protein network | https://string-db.org/network/9606.ENSP00000251038 | Zinc finger CCCH domain-containing protein 14; Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides; Zinc fingers CCCH-type |
| LMAN1 protein network | https://string-db.org/network/9606.ENSP00000251047 | Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of [...] |
| ANGEL1 protein network | https://string-db.org/network/9606.ENSP00000251089 | Angel homolog 1; Belongs to the CCR4/nocturin family |
| CNGB1 protein network | https://string-db.org/network/9606.ENSP00000251102 | Cyclic nucleotide-gated cation channel beta-1; Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal tran [...] |
| CDADC1 protein network | https://string-db.org/network/9606.ENSP00000251108 | Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis; Belongs to the cytidine and deoxycytidylate deaminase family |
| ZFYVE26 protein network | https://string-db.org/network/9606.ENSP00000251119 | Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and act [...] |
| NALCN protein network | https://string-db.org/network/9606.ENSP00000251127 | Sodium leak channel non-selective protein; Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and [...] |
| C16orf62 protein network | https://string-db.org/network/9606.ENSP00000251143 | UPF0505 protein C16orf62; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association [...] |
| DOCK7 protein network | https://string-db.org/network/9606.ENSP00000251157 | Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a [...] |
| CORO7 protein network | https://string-db.org/network/9606.ENSP00000251166 | Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interact [...] |
| SEC14L5 protein network | https://string-db.org/network/9606.ENSP00000251170 | SEC14-like protein 5; SEC14 like lipid binding 5; PRELI domain containing |
| PBX4 protein network | https://string-db.org/network/9606.ENSP00000251203 | Pre-B-cell leukemia transcription factor 4; TALE class homeoboxes and pseudogenes; Belongs to the TALE/PBX homeobox family |
| DHX40 protein network | https://string-db.org/network/9606.ENSP00000251241 | Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily |
| DTWD1 protein network | https://string-db.org/network/9606.ENSP00000251250 | DTW domain containing 1; Belongs to the DTW family |
| MEGF8 protein network | https://string-db.org/network/9606.ENSP00000251268 | Multiple epidermal growth factor-like domains protein 8; Multiple EGF like domains 8 |
| ZNF221 protein network | https://string-db.org/network/9606.ENSP00000251269 | Zinc finger protein 221; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HCN2 protein network | https://string-db.org/network/9606.ENSP00000251287 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to [...] |
| IGSF21 protein network | https://string-db.org/network/9606.ENSP00000251296 | Immunoglobulin superfamily member 21; Immunoglobulin like domain containing |
| SLX1A protein network | https://string-db.org/network/9606.ENSP00000251303 | SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae); Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during [...] |
| GNAT2 protein network | https://string-db.org/network/9606.ENSP00000251337 | Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Tra [...] |
| KHNYN protein network | https://string-db.org/network/9606.ENSP00000251343 | Protein KHNYN; KH and NYN domain containing; Belongs to the N4BP1 family |
| CERS4 protein network | https://string-db.org/network/9606.ENSP00000251363 | Ceramide synthase 4; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing dif [...] |
| LILRA1 protein network | https://string-db.org/network/9606.ENSP00000251372 | Leukocyte immunoglobulin-like receptor subfamily A member 1; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors |
| LILRA2 protein network | https://string-db.org/network/9606.ENSP00000251377 | Leukocyte immunoglobulin-like receptor subfamily A member 2; Part of the innate immune responses against microbial infection. Specifically recognizes a set of N-terminally truncated immunoglobuli [...] |
| TUBG2 protein network | https://string-db.org/network/9606.ENSP00000251412 | Tubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentrio [...] |
| TUBG1 protein network | https://string-db.org/network/9606.ENSP00000251413 | Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentrio [...] |
| RPS16 protein network | https://string-db.org/network/9606.ENSP00000251453 | Ribosomal protein S16 |
| MAST1 protein network | https://string-db.org/network/9606.ENSP00000251472 | Microtubule-associated serine/threonine-protein kinase 1; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modula [...] |
| NCAPG protein network | https://string-db.org/network/9606.ENSP00000251496 | Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...] |
| RABGAP1L protein network | https://string-db.org/network/9606.ENSP00000251507 | Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A- GDP. Plays a role in endocytosis a [...] |
| ESYT2 protein network | https://string-db.org/network/9606.ENSP00000251527 | Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glyceroph [...] |
| ALOX12 protein network | https://string-db.org/network/9606.ENSP00000251535 | Arachidonate 12-lipoxygenase, 12S-type; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectr [...] |
| UGT2A3 protein network | https://string-db.org/network/9606.ENSP00000251566 | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...] |
| ADAMTS2 protein network | https://string-db.org/network/9606.ENSP00000251582 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a ro [...] |
| NARFL protein network | https://string-db.org/network/9606.ENSP00000251588 | Cytosolic Fe-S cluster assembly factor NARFL; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster [...] |
| HBA2 protein network | https://string-db.org/network/9606.ENSP00000251595 | Hemoglobin subunit alpha 2; Involved in oxygen transport from the lung to the various peripheral tissues; Hemoglobin subunits |
| TRNT1 protein network | https://string-db.org/network/9606.ENSP00000251607 | CCA tRNA nucleotidyltransferase 1, mitochondrial; Isoform 1: Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using [...] |
| DHX29 protein network | https://string-db.org/network/9606.ENSP00000251636 | ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher [...] |
| DHX58 protein network | https://string-db.org/network/9606.ENSP00000251642 | Probable ATP-dependent RNA helicase DHX58; Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required [...] |
| KRT12 protein network | https://string-db.org/network/9606.ENSP00000251643 | Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (B [...] |
| KRT31 protein network | https://string-db.org/network/9606.ENSP00000251645 | Keratin, type I cuticular Ha1; Keratins, type I |
| KRT33B protein network | https://string-db.org/network/9606.ENSP00000251646 | Keratin, type I cuticular Ha3-II; Keratins, type I; Belongs to the intermediate filament family |
| KIAA1244 protein network | https://string-db.org/network/9606.ENSP00000251691 | Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic [...] |
| SLC4A5 protein network | https://string-db.org/network/9606.ENSP00000251768 | Electrogenic sodium bicarbonate cotransporter 4; Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a hous [...] |
| SNX4 protein network | https://string-db.org/network/9606.ENSP00000251775 | Sorting nexin-4; May be involved in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation; Belongs to the sorting nex [...] |
| GRHL2 protein network | https://string-db.org/network/9606.ENSP00000251808 | Grainyhead-like protein 2 homolog; Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' [...] |
| RRM2B protein network | https://string-db.org/network/9606.ENSP00000251810 | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in c [...] |
| RAF1 protein network | https://string-db.org/network/9606.ENSP00000251849 | RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this c [...] |
| TDRD1 protein network | https://string-db.org/network/9606.ENSP00000251864 | Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for t [...] |
| MED17 protein network | https://string-db.org/network/9606.ENSP00000251871 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| SCML2 protein network | https://string-db.org/network/9606.ENSP00000251900 | Sex comb on midleg-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...] |
| NXPE1 protein network | https://string-db.org/network/9606.ENSP00000251921 | NXPE family member 1; Neurexophilin and PC-esterase domain family member 1; Belongs to the NXPE family |
| TSG101 protein network | https://string-db.org/network/9606.ENSP00000251968 | Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of end [...] |
| KIAA0930 protein network | https://string-db.org/network/9606.ENSP00000251993 | Uncharacterized protein KIAA0930; KIAA0930 |
| DHX35 protein network | https://string-db.org/network/9606.ENSP00000252011 | Probable ATP-dependent RNA helicase DHX35; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily |
| TRPC4AP protein network | https://string-db.org/network/9606.ENSP00000252015 | Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX [...] |
| C20orf194 protein network | https://string-db.org/network/9606.ENSP00000252032 | Uncharacterized protein C20orf194; May act as an effector for ARL3 |
| FKBP6 protein network | https://string-db.org/network/9606.ENSP00000252037 | Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germli [...] |
| CUL9 protein network | https://string-db.org/network/9606.ENSP00000252050 | Cullin-9; Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynami [...] |
| ACTR3C protein network | https://string-db.org/network/9606.ENSP00000252071 | Actin-related protein 3C; May play a role in the suppression of metastatic potential in lung adenoma carcinoma cells; Actin related proteins |
| PCDHGA12 protein network | https://string-db.org/network/9606.ENSP00000252085 | Protocadherin gamma-A12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadh [...] |
| PCDHGC5 protein network | https://string-db.org/network/9606.ENSP00000252087 | Protocadherin gamma-C5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| TMCO6 protein network | https://string-db.org/network/9606.ENSP00000252100 | Transmembrane and coiled-coil domain-containing protein 6; Armadillo-like helical domain containing |
| NDUFA2 protein network | https://string-db.org/network/9606.ENSP00000252102 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| TRMT2A protein network | https://string-db.org/network/9606.ENSP00000252136 | tRNA (uracil-5-)-methyltransferase homolog A; May be involved in nucleic acid metabolism and/or modifications; tRNA methyltransferases |
| DGCR14 protein network | https://string-db.org/network/9606.ENSP00000252137 | Protein DGCR14; May be involved in pre-mRNA splicing |
| MICB protein network | https://string-db.org/network/9606.ENSP00000252229 | MHC class I polypeptide-related sequence B; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NK [...] |
| KRT5 protein network | https://string-db.org/network/9606.ENSP00000252242 | Keratin, type II cytoskeletal 5; Keratins, type II |
| KRT1 protein network | https://string-db.org/network/9606.ENSP00000252244 | Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In comple [...] |
| KRT75 protein network | https://string-db.org/network/9606.ENSP00000252245 | Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle |
| KRT6C protein network | https://string-db.org/network/9606.ENSP00000252250 | Keratin, type II cytoskeletal 6C; Keratins, type II; Belongs to the intermediate filament family |
| KRT6B protein network | https://string-db.org/network/9606.ENSP00000252252 | Keratin, type II cytoskeletal 6B; Keratins, type II; Belongs to the intermediate filament family |
| GALNT8 protein network | https://string-db.org/network/9606.ENSP00000252318 | Probable polypeptide N-acetylgalactosaminyltransferase 8; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-select [...] |
| KCNA5 protein network | https://string-db.org/network/9606.ENSP00000252321 | Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective [...] |
| FAM155B protein network | https://string-db.org/network/9606.ENSP00000252338 | Transmembrane protein FAM155B; Family with sequence similarity 155 member B; Belongs to the FAM155 family |
| ELOF1 protein network | https://string-db.org/network/9606.ENSP00000252445 | Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions |
| CNN1 protein network | https://string-db.org/network/9606.ENSP00000252456 | Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...] |
| ZSCAN10 protein network | https://string-db.org/network/9606.ENSP00000252463 | Zinc finger and SCAN domain-containing protein 10; Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression o [...] |
| PVRL2 protein network | https://string-db.org/network/9606.ENSP00000252483 | Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell prolife [...] |
| APOE protein network | https://string-db.org/network/9606.ENSP00000252486 | Apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chyl [...] |
| ENSG00000224916 protein network | https://string-db.org/network/9606.ENSP00000252490 | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism a [...] |
| ALLC protein network | https://string-db.org/network/9606.ENSP00000252505 | Probable allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals |
| GADD45G protein network | https://string-db.org/network/9606.ENSP00000252506 | Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 [...] |
| XPO7 protein network | https://string-db.org/network/9606.ENSP00000252512 | Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. [...] |
| FAM98C protein network | https://string-db.org/network/9606.ENSP00000252530 | Protein FAM98C; Family with sequence similarity 98 member C |
| SAFB2 protein network | https://string-db.org/network/9606.ENSP00000252542 | Scaffold attachment factor B2; Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation; RNA binding motif [...] |
| NCAN protein network | https://string-db.org/network/9606.ENSP00000252575 | Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; bind [...] |
| PLVAP protein network | https://string-db.org/network/9606.ENSP00000252590 | Plasmalemma vesicle-associated protein; Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability |
| BST2 protein network | https://string-db.org/network/9606.ENSP00000252593 | Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to t [...] |
| SLC27A1 protein network | https://string-db.org/network/9606.ENSP00000252595 | Long-chain fatty acid transport protein 1; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-speci [...] |
| USHBP1 protein network | https://string-db.org/network/9606.ENSP00000252597 | Usher syndrome type-1C protein-binding protein 1; USH1 protein network component harmonin binding protein 1; Belongs to the MCC family |
| COLGALT1 protein network | https://string-db.org/network/9606.ENSP00000252599 | Procollagen galactosyltransferase 1; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the fo [...] |
| MRPL34 protein network | https://string-db.org/network/9606.ENSP00000252602 | Mitochondrial ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family |
| PGLS protein network | https://string-db.org/network/9606.ENSP00000252603 | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate |
| LSM7 protein network | https://string-db.org/network/9606.ENSP00000252622 | U6 snRNA-associated Sm-like protein LSm7; Binds specifically to the 3'-terminal U-tract of U6 snRNA and is probably a component of the spliceosome; Belongs to the snRNP Sm proteins family |
| RSPH3 protein network | https://string-db.org/network/9606.ENSP00000252655 | Radial spoke head protein 3 homolog; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK an [...] |
| MAS1 protein network | https://string-db.org/network/9606.ENSP00000252660 | Proto-oncogene Mas; Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor le [...] |
| MLLT1 protein network | https://string-db.org/network/9606.ENSP00000252674 | Protein ENL; Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymera [...] |
| BMP15 protein network | https://string-db.org/network/9606.ENSP00000252677 | Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morp [...] |
| ACTN4 protein network | https://string-db.org/network/9606.ENSP00000252699 | Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular tra [...] |
| NDUFA10 protein network | https://string-db.org/network/9606.ENSP00000252711 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed no [...] |
| EPO protein network | https://string-db.org/network/9606.ENSP00000252723 | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR lea [...] |
| CACNG6 protein network | https://string-db.org/network/9606.ENSP00000252729 | Voltage-dependent calcium channel gamma-6 subunit; Thought to stabilize the calcium channel in an inactivated (closed) state; Calcium channel auxiliary gamma subunits |
| ZSWIM6 protein network | https://string-db.org/network/9606.ENSP00000252744 | Zinc finger SWIM-type containing 6 |
| ZNF764 protein network | https://string-db.org/network/9606.ENSP00000252797 | Zinc finger protein 764; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF747 protein network | https://string-db.org/network/9606.ENSP00000252799 | KRAB domain-containing protein ZNF747; Zinc finger protein 747; Zinc fingers C2H2-type |
| PXDN protein network | https://string-db.org/network/9606.ENSP00000252804 | Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system. Plays a role in extracellular ma [...] |
| GDF15 protein network | https://string-db.org/network/9606.ENSP00000252809 | Growth differentiation factor 15; Belongs to the TGF-beta family |
| JUND protein network | https://string-db.org/network/9606.ENSP00000252818 | Transcription factor jun-D; Transcription factor binding AP-1 sites; Belongs to the bZIP family. Jun subfamily |
| HRC protein network | https://string-db.org/network/9606.ENSP00000252825 | Sarcoplasmic reticulum histidine-rich calcium-binding protein; May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle |
| TRPM4 protein network | https://string-db.org/network/9606.ENSP00000252826 | Transient receptor potential cation channel subfamily M member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in [...] |
| OR11H1 protein network | https://string-db.org/network/9606.ENSP00000252835 | Olfactory receptor 11H1; Odorant receptor; Olfactory receptors, family 11 |
| ZNF557 protein network | https://string-db.org/network/9606.ENSP00000252840 | Zinc finger protein 557; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NUMBL protein network | https://string-db.org/network/9606.ENSP00000252891 | Numb-like protein; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing [...] |
| ATXN10 protein network | https://string-db.org/network/9606.ENSP00000252934 | Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycos [...] |
| CALY protein network | https://string-db.org/network/9606.ENSP00000252939 | Neuron-specific vesicular protein calcyon; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis |
| HBZ protein network | https://string-db.org/network/9606.ENSP00000252951 | Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin |
| MNX1 protein network | https://string-db.org/network/9606.ENSP00000252971 | Motor neuron and pancreas homeobox protein 1; Putative transcription factor involved in pancreas development and function; HOXL subclass homeoboxes |
| CEP85 protein network | https://string-db.org/network/9606.ENSP00000252992 | Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belon [...] |
| TAF4 protein network | https://string-db.org/network/9606.ENSP00000252996 | Transcription initiation factor TFIID subunit 4; Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repres [...] |
| GATA5 protein network | https://string-db.org/network/9606.ENSP00000252997 | Transcription factor GATA-5; Transcription factor required during cardiovascular development. Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity [...] |
| RBBP8NL protein network | https://string-db.org/network/9606.ENSP00000252998 | RBBP8 N-terminal-like protein; RBBP8 N-terminal like |
| LAMA5 protein network | https://string-db.org/network/9606.ENSP00000252999 | Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| PRDM12 protein network | https://string-db.org/network/9606.ENSP00000253008 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; PR/SET domain family |
| UBE2M protein network | https://string-db.org/network/9606.ENSP00000253023 | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the [...] |
| TRIM28 protein network | https://string-db.org/network/9606.ENSP00000253024 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome [...] |
| YIPF2 protein network | https://string-db.org/network/9606.ENSP00000253031 | Protein YIPF2; Yip1 domain family member 2 |
| EIF2S3 protein network | https://string-db.org/network/9606.ENSP00000253039 | Eukaryotic translation initiation factor 2 subunit 3; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a [...] |
| TMEM160 protein network | https://string-db.org/network/9606.ENSP00000253047 | Transmembrane protein 160 |
| ZC3H4 protein network | https://string-db.org/network/9606.ENSP00000253048 | Zinc finger CCCH domain-containing protein 4; Armadillo-like helical domain containing |
| MAP3K10 protein network | https://string-db.org/network/9606.ENSP00000253055 | Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway; Mitogen-activated protein kinase kinase kinases |
| SESN2 protein network | https://string-db.org/network/9606.ENSP00000253063 | Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 a [...] |
| CCDC62 protein network | https://string-db.org/network/9606.ENSP00000253079 | Coiled-coil domain-containing protein 62; Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocort [...] |
| HIP1R protein network | https://string-db.org/network/9606.ENSP00000253083 | Huntingtin-interacting protein 1-related protein; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via [...] |
| MRPL4 protein network | https://string-db.org/network/9606.ENSP00000253099 | Mitochondrial ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family |
| PPAN protein network | https://string-db.org/network/9606.ENSP00000253107 | Suppressor of SWI4 1 homolog; May have a role in cell growth |
| EIF3G protein network | https://string-db.org/network/9606.ENSP00000253108 | Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...] |
| ANGPTL6 protein network | https://string-db.org/network/9606.ENSP00000253109 | Angiopoietin-related protein 6; May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial [...] |
| C19orf66 protein network | https://string-db.org/network/9606.ENSP00000253110 | Repressor of yield of DENV protein; Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA vi [...] |
| SLC6A8 protein network | https://string-db.org/network/9606.ENSP00000253122 | Sodium- and chloride-dependent creatine transporter 1; Required for the uptake of creatine in muscles and brain; Solute carriers |
| ZNF331 protein network | https://string-db.org/network/9606.ENSP00000253144 | Zinc finger protein 331; May be involved in transcriptional regulation. May play a role in spermatogenesis; Zinc fingers C2H2-type |
| ZNF236 protein network | https://string-db.org/network/9606.ENSP00000253159 | Zinc finger protein 236; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SLC7A10 protein network | https://string-db.org/network/9606.ENSP00000253188 | Asc-type amino acid transporter 1; Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobil [...] |
| LRP3 protein network | https://string-db.org/network/9606.ENSP00000253193 | Low-density lipoprotein receptor-related protein 3; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however [...] |
| C12orf65 protein network | https://string-db.org/network/9606.ENSP00000253233 | Probable peptide chain release factor C12orf65, mitochondrial; May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of tr [...] |
| GRWD1 protein network | https://string-db.org/network/9606.ENSP00000253237 | Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting [...] |
| NOL11 protein network | https://string-db.org/network/9606.ENSP00000253247 | Nucleolar protein 11; Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b; UTPa subcomplex |
| PKDREJ protein network | https://string-db.org/network/9606.ENSP00000253255 | Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acro [...] |
| NUTM2F protein network | https://string-db.org/network/9606.ENSP00000253262 | NUT family member 2F; Belongs to the NUT family |
| SLC35D2 protein network | https://string-db.org/network/9606.ENSP00000253270 | UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-M [...] |
| PPIL4 protein network | https://string-db.org/network/9606.ENSP00000253329 | Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); [...] |
| BPIFB1 protein network | https://string-db.org/network/9606.ENSP00000253354 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs t [...] |
| BPIFA2 protein network | https://string-db.org/network/9606.ENSP00000253362 | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family |
| RBM39 protein network | https://string-db.org/network/9606.ENSP00000253363 | RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1 (By similarity). May be involved in pre-mRNA splicing process; RNA b [...] |
| DEFB118 protein network | https://string-db.org/network/9606.ENSP00000253381 | Beta-defensin 118; Has antibacterial activity; Defensins, beta |
| ACSS2 protein network | https://string-db.org/network/9606.ENSP00000253382 | Acetyl-coenzyme A synthetase, cytoplasmic; Activates acetate so that it can be used for lipid synthesis or for energy generation; Acyl-CoA synthetase family |
| ARHGEF9 protein network | https://string-db.org/network/9606.ENSP00000253401 | Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters; Pleckstrin homology domain containing |
| C1QL1 protein network | https://string-db.org/network/9606.ENSP00000253407 | C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related |
| HIGD1B protein network | https://string-db.org/network/9606.ENSP00000253410 | HIG1 hypoxia inducible domain family member 1B |
| ATP6V1E1 protein network | https://string-db.org/network/9606.ENSP00000253413 | V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intrace [...] |
| EMC8 protein network | https://string-db.org/network/9606.ENSP00000253457 | ER membrane protein complex subunit 8 |
| GSE1 protein network | https://string-db.org/network/9606.ENSP00000253458 | Genetic suppressor element 1; Gse1 coiled-coil protein |
| GINS2 protein network | https://string-db.org/network/9606.ENSP00000253462 | DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind pref [...] |
| F12 protein network | https://string-db.org/network/9606.ENSP00000253496 | Coagulation factor XII; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein [...] |
| ABCB7 protein network | https://string-db.org/network/9606.ENSP00000253577 | ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iro [...] |
| HAUS8 protein network | https://string-db.org/network/9606.ENSP00000253669 | HAUS augmin-like complex subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| EMR3 protein network | https://string-db.org/network/9606.ENSP00000253673 | Adhesion G protein-coupled receptor E3; Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor [...] |
| MRPS25 protein network | https://string-db.org/network/9606.ENSP00000253686 | Mitochondrial ribosomal protein S25 |
| CAPN7 protein network | https://string-db.org/network/9606.ENSP00000253693 | Calpain-7; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family |
| C3orf20 protein network | https://string-db.org/network/9606.ENSP00000253697 | Uncharacterized protein C3orf20; Chromosome 3 open reading frame 20 |
| ZFYVE20 protein network | https://string-db.org/network/9606.ENSP00000253699 | Rabenosyn-5; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathr [...] |
| NAPSA protein network | https://string-db.org/network/9606.ENSP00000253719 | Napsin-A; May be involved in processing of pneumocyte surfactant precursors |
| NR1H2 protein network | https://string-db.org/network/9606.ENSP00000253727 | Oxysterols receptor LXR-beta; Nuclear receptor. Binds preferentially to double- stranded oligonucleotide direct repeats having the consensus half- site sequence 5'-AGGTCA-3' and 4-nt spacing (DR- [...] |
| PDLIM4 protein network | https://string-db.org/network/9606.ENSP00000253754 | PDZ and LIM domain protein 4; Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inac [...] |
| GFPT2 protein network | https://string-db.org/network/9606.ENSP00000253778 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N [...] |
| ACLY protein network | https://string-db.org/network/9606.ENSP00000253792 | ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous t [...] |
| VPS25 protein network | https://string-db.org/network/9606.ENSP00000253794 | Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation [...] |
| RAMP2 protein network | https://string-db.org/network/9606.ENSP00000253796 | Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CAL [...] |
| AOC2 protein network | https://string-db.org/network/9606.ENSP00000253799 | Retina-specific copper amine oxidase; Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulat [...] |
| G6PC protein network | https://string-db.org/network/9606.ENSP00000253801 | Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose pr [...] |
| PCDHAC1 protein network | https://string-db.org/network/9606.ENSP00000253807 | Protocadherin alpha-C1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| PCDHGA3 protein network | https://string-db.org/network/9606.ENSP00000253812 | Protocadherin gamma-A3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| NDFIP1 protein network | https://string-db.org/network/9606.ENSP00000253814 | NEDD4 family-interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result [...] |
| EXOC4 protein network | https://string-db.org/network/9606.ENSP00000253861 | Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane |
| PPFIA1 protein network | https://string-db.org/network/9606.ENSP00000253925 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...] |
| BARX1 protein network | https://string-db.org/network/9606.ENSP00000253968 | Homeobox protein BarH-like 1; Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars [...] |
| WDR44 protein network | https://string-db.org/network/9606.ENSP00000254029 | WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling (By similarity); WD repeat domain containing |
| ZCCHC9 protein network | https://string-db.org/network/9606.ENSP00000254037 | Zinc finger CCHC domain-containing protein 9; May down-regulate transcription mediated by NF-kappa-B and the serum response element; Protein phosphatase 1 regulatory subunits |
| KRT15 protein network | https://string-db.org/network/9606.ENSP00000254043 | Keratin, type I cytoskeletal 15; Keratins, type I |
| TNS4 protein network | https://string-db.org/network/9606.ENSP00000254051 | Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by casp [...] |
| RARA protein network | https://string-db.org/network/9606.ENSP00000254066 | Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic [...] |
| KRTAP9-8 protein network | https://string-db.org/network/9606.ENSP00000254072 | Keratin-associated protein 9-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| PPP1R1B protein network | https://string-db.org/network/9606.ENSP00000254079 | Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1 |
| FMO5 protein network | https://string-db.org/network/9606.ENSP00000254090 | Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme |
| PRKAB2 protein network | https://string-db.org/network/9606.ENSP00000254101 | 5'-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy m [...] |
| FUS protein network | https://string-db.org/network/9606.ENSP00000254108 | RNA-binding protein FUS; Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single- stranded DNAs and D-loop formation in superhelical doub [...] |
| ZNF132 protein network | https://string-db.org/network/9606.ENSP00000254166 | Zinc finger protein 132; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| USP29 protein network | https://string-db.org/network/9606.ENSP00000254181 | Ubiquitin specific peptidase 29 |
| CHSY1 protein network | https://string-db.org/network/9606.ENSP00000254190 | Chondroitin sulfate synthase 1; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...] |
| SNRPA1 protein network | https://string-db.org/network/9606.ENSP00000254193 | U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA; Belongs to the U2 small nuclear ribonucleoprotein A fami [...] |
| NR0B2 protein network | https://string-db.org/network/9606.ENSP00000254227 | Nuclear receptor subfamily 0 group B member 2; Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of [...] |
| THAP1 protein network | https://string-db.org/network/9606.ENSP00000254250 | THAP domain-containing protein 1; DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT [...] |
| RHPN2 protein network | https://string-db.org/network/9606.ENSP00000254260 | Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA [...] |
| ACTR10 protein network | https://string-db.org/network/9606.ENSP00000254286 | Actin related protein 10 homolog; Belongs to the actin family |
| LGALS3 protein network | https://string-db.org/network/9606.ENSP00000254301 | Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for ter [...] |
| DNAJB1 protein network | https://string-db.org/network/9606.ENSP00000254322 | DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 trans [...] |
| ZSWIM4 protein network | https://string-db.org/network/9606.ENSP00000254323 | Zinc finger SWIM-type containing 4 |
| HGNC:9982 protein network | https://string-db.org/network/9606.ENSP00000254325 | MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required fo [...] |
| C19orf57 protein network | https://string-db.org/network/9606.ENSP00000254336 | Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 |
| DCAF15 protein network | https://string-db.org/network/9606.ENSP00000254337 | DDB1- and CUL4-associated factor 15; May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase; DDB1 and CUL4 associated factors |
| TRIM21 protein network | https://string-db.org/network/9606.ENSP00000254436 | E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with [...] |
| WDR7 protein network | https://string-db.org/network/9606.ENSP00000254442 | WD repeat-containing protein 7; Armadillo-like helical domain containing |
| SMARCC1 protein network | https://string-db.org/network/9606.ENSP00000254480 | SWI/SNF complex subunit SMARCC1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chroma [...] |
| SLC6A11 protein network | https://string-db.org/network/9606.ENSP00000254488 | Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter [...] |
| NUP210 protein network | https://string-db.org/network/9606.ENSP00000254508 | Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity; Nucleoporins |
| HSD17B7 protein network | https://string-db.org/network/9606.ENSP00000254521 | 3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Short chain dehydrogenase/reductase superfamily |
| EMILIN2 protein network | https://string-db.org/network/9606.ENSP00000254528 | EMILIN-2; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vesse [...] |
| DNHD1 protein network | https://string-db.org/network/9606.ENSP00000254579 | Dynein heavy chain domain 1 |
| RRP8 protein network | https://string-db.org/network/9606.ENSP00000254605 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy [...] |
| TIMM10B protein network | https://string-db.org/network/9606.ENSP00000254616 | Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mit [...] |
| EFR3A protein network | https://string-db.org/network/9606.ENSP00000254624 | Protein EFR3 homolog A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphat [...] |
| OC90 protein network | https://string-db.org/network/9606.ENSP00000254627 | Otoconin 90; It is unlikely that this protein has phospholipase A2 activity |
| PTCD3 protein network | https://string-db.org/network/9606.ENSP00000254630 | Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation |
| ILKAP protein network | https://string-db.org/network/9606.ENSP00000254654 | Integrin-linked kinase-associated serine/threonine phosphatase 2C; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose a [...] |
| PER2 protein network | https://string-db.org/network/9606.ENSP00000254657 | Period circadian protein homolog 2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiol [...] |
| RAMP1 protein network | https://string-db.org/network/9606.ENSP00000254661 | Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP [...] |
| SCLY protein network | https://string-db.org/network/9606.ENSP00000254663 | Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L- alanine and elemental selenium; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family |
| PTPRE protein network | https://string-db.org/network/9606.ENSP00000254667 | Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in o [...] |
| CARD6 protein network | https://string-db.org/network/9606.ENSP00000254691 | Caspase recruitment domain-containing protein 6; May be involved in apoptosis; Caspase recruitment domain containing |
| RAP1GAP2 protein network | https://string-db.org/network/9606.ENSP00000254695 | Rap1 GTPase-activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state |
| RPA1 protein network | https://string-db.org/network/9606.ENSP00000254719 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during [...] |
| SERPINF1 protein network | https://string-db.org/network/9606.ENSP00000254722 | Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stress [...] |
| EEFSEC protein network | https://string-db.org/network/9606.ENSP00000254730 | Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine direc [...] |
| COQ3 protein network | https://string-db.org/network/9606.ENSP00000254759 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-bi [...] |
| POPDC3 protein network | https://string-db.org/network/9606.ENSP00000254765 | Popeye domain-containing protein 3; May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding |
| LANCL2 protein network | https://string-db.org/network/9606.ENSP00000254770 | LanC-like protein 2; Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes |
| GRSF1 protein network | https://string-db.org/network/9606.ENSP00000254799 | G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs c [...] |
| IGJ protein network | https://string-db.org/network/9606.ENSP00000254801 | Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it in [...] |
| UTP3 protein network | https://string-db.org/network/9606.ENSP00000254803 | Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity); Belongs to the SAS10 f [...] |
| H3F3B protein network | https://string-db.org/network/9606.ENSP00000254810 | H3 histone, family 3B (H3.3B); Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cel [...] |
| TRIM47 protein network | https://string-db.org/network/9606.ENSP00000254816 | Tripartite motif containing 47; Ring finger proteins |
| KDM6B protein network | https://string-db.org/network/9606.ENSP00000254846 | Lysine-specific demethylase 6B; Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethyl [...] |
| GUCY2D protein network | https://string-db.org/network/9606.ENSP00000254854 | Retinal guanylyl cyclase 1; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of [...] |
| CLEC10A protein network | https://string-db.org/network/9606.ENSP00000254868 | C-type lectin domain family 10 member A; Probable role in regulating adaptive and innate immune responses. Binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine unit [...] |
| HRSP12 protein network | https://string-db.org/network/9606.ENSP00000254878 | 2-iminobutanoate/2-iminopropanoate deaminase; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of a [...] |
| MATN2 protein network | https://string-db.org/network/9606.ENSP00000254898 | Matrilin-2; Involved in matrix assembly; Matrilins |
| BRD8 protein network | https://string-db.org/network/9606.ENSP00000254900 | Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHT [...] |
| ERAL1 protein network | https://string-db.org/network/9606.ENSP00000254928 | GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide [...] |
| NIP7 protein network | https://string-db.org/network/9606.ENSP00000254940 | 60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family |
| TERF2 protein network | https://string-db.org/network/9606.ENSP00000254942 | Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes [...] |
| VPS4A protein network | https://string-db.org/network/9606.ENSP00000254950 | Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes thei [...] |
| JAG1 protein network | https://string-db.org/network/9606.ENSP00000254958 | Protein jagged-1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early [...] |
| HSPA12B protein network | https://string-db.org/network/9606.ENSP00000254963 | Heat shock protein family A member 12B; Belongs to the heat shock protein 70 family |
| SNAP25 protein network | https://string-db.org/network/9606.ENSP00000254976 | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Ass [...] |
| NXT1 protein network | https://string-db.org/network/9606.ENSP00000254998 | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved [...] |
| RIN2 protein network | https://string-db.org/network/9606.ENSP00000255006 | Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF [...] |
| SSTR4 protein network | https://string-db.org/network/9606.ENSP00000255008 | Somatostatin receptor type 4; Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibit [...] |
| CRP protein network | https://string-db.org/network/9606.ENSP00000255030 | C-reactive protein; Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-depen [...] |
| HAPLN2 protein network | https://string-db.org/network/9606.ENSP00000255039 | Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan- associated matrix in the central [...] |
| APCS protein network | https://string-db.org/network/9606.ENSP00000255040 | Serum amyloid P-component; Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin; Belongs t [...] |
| IGHMBP2 protein network | https://string-db.org/network/9606.ENSP00000255078 | DNA-binding protein SMUBP-2; 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of th [...] |
| ACY3 protein network | https://string-db.org/network/9606.ENSP00000255082 | N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acid [...] |
| ALDH3B2 protein network | https://string-db.org/network/9606.ENSP00000255084 | Aldehyde dehydrogenase family 3 member B2; Oxidizes medium and long chain aldehydes into non-toxic fatty acids; Belongs to the aldehyde dehydrogenase family |
| MTL5 protein network | https://string-db.org/network/9606.ENSP00000255087 | Tesmin; May have a role in spermatogenesis; Belongs to the lin-54 family |
| DPH2 protein network | https://string-db.org/network/9606.ENSP00000255108 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation el [...] |
| NASP protein network | https://string-db.org/network/9606.ENSP00000255120 | Nuclear autoantigenic sperm protein; Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulat [...] |
| ZNF334 protein network | https://string-db.org/network/9606.ENSP00000255129 | Zinc finger protein 334; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PABPC1L protein network | https://string-db.org/network/9606.ENSP00000255136 | Polyadenylate-binding protein 1-like; poly(A) binding protein cytoplasmic 1 like; RNA binding motif containing |
| ZSWIM3 protein network | https://string-db.org/network/9606.ENSP00000255152 | Zinc finger SWIM-type containing 3 |
| DMGDH protein network | https://string-db.org/network/9606.ENSP00000255189 | Dimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro |
| BHMT2 protein network | https://string-db.org/network/9606.ENSP00000255192 | S-methylmethionine--homocysteine S-methyltransferase BHMT2; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl d [...] |
| AP3B1 protein network | https://string-db.org/network/9606.ENSP00000255194 | AP-3 complex subunit beta-1; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and [...] |
| ZBED3 protein network | https://string-db.org/network/9606.ENSP00000255198 | Zinc finger BED domain-containing protein 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved i [...] |
| SYT4 protein network | https://string-db.org/network/9606.ENSP00000255224 | Synaptotagmin-4; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...] |
| SLC14A2 protein network | https://string-db.org/network/9606.ENSP00000255226 | Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major rol [...] |
| NMUR2 protein network | https://string-db.org/network/9606.ENSP00000255262 | Neuromedin-U receptor 2; Receptor for the neuromedin-U and neuromedin-S neuropeptides; Belongs to the G-protein coupled receptor 1 family |
| PDE6A protein network | https://string-db.org/network/9606.ENSP00000255266 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal; Belongs to the cyclic nucleotide pho [...] |
| USPL1 protein network | https://string-db.org/network/9606.ENSP00000255304 | SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more e [...] |
| XPO4 protein network | https://string-db.org/network/9606.ENSP00000255305 | Exportin-4; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. [...] |
| RNF17 protein network | https://string-db.org/network/9606.ENSP00000255324 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad- MAX heterodimers. Can recruit Mad transcriptional re [...] |
| CHRM3 protein network | https://string-db.org/network/9606.ENSP00000255380 | Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...] |
| MYH4 protein network | https://string-db.org/network/9606.ENSP00000255381 | Myosin-4; Muscle contraction; Myosin heavy chains |
| PEMT protein network | https://string-db.org/network/9606.ENSP00000255389 | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidyleth [...] |
| SCO1 protein network | https://string-db.org/network/9606.ENSP00000255390 | Protein SCO1 homolog, mitochondrial; Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX; Belongs to the SCO1/2 [...] |
| CHI3L1 protein network | https://string-db.org/network/9606.ENSP00000255409 | Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to an [...] |
| MYBPH protein network | https://string-db.org/network/9606.ENSP00000255416 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Fibronectin type III domain containing |
| DCLK1 protein network | https://string-db.org/network/9606.ENSP00000255448 | Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium- signaling pathway controlling neuronal migration in the developing brain. May also participate in functio [...] |
| CCNA1 protein network | https://string-db.org/network/9606.ENSP00000255465 | Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additi [...] |
| RFXAP protein network | https://string-db.org/network/9606.ENSP00000255476 | Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters |
| RNF128 protein network | https://string-db.org/network/9606.ENSP00000255499 | E3 ubiquitin-protein ligase RNF128; E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcripti [...] |
| BTBD2 protein network | https://string-db.org/network/9606.ENSP00000255608 | BTB/POZ domain-containing protein 2; BTB domain containing 2 |
| SUV420H2 protein network | https://string-db.org/network/9606.ENSP00000255613 | Histone-lysine N-methyltransferase KMT5C; Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic tra [...] |
| HSPBP1 protein network | https://string-db.org/network/9606.ENSP00000255631 | Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination media [...] |
| CSNK1G2 protein network | https://string-db.org/network/9606.ENSP00000255641 | Casein kinase I isoform gamma-2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...] |
| RTTN protein network | https://string-db.org/network/9606.ENSP00000255674 | Rotatin; Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, [...] |
| MACROD1 protein network | https://string-db.org/network/9606.ENSP00000255681 | O-acetyl-ADP-ribose deacetylase MACROD1; Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates [...] |
| RARRES3 protein network | https://string-db.org/network/9606.ENSP00000255688 | Retinoic acid receptor responder protein 3; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolami [...] |
| HRASLS2 protein network | https://string-db.org/network/9606.ENSP00000255695 | HRAS-like suppressor 2; Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most su [...] |
| FOPNL protein network | https://string-db.org/network/9606.ENSP00000255759 | LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia. Required for the recruitement of PLK1 to centrosomes and S phase progression |
| MED10 protein network | https://string-db.org/network/9606.ENSP00000255764 | Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| CCDC134 protein network | https://string-db.org/network/9606.ENSP00000255784 | Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tu [...] |
| SEC14L4 protein network | https://string-db.org/network/9606.ENSP00000255858 | SEC14-like protein 4; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids; SEC14 family |
| PI4KA protein network | https://string-db.org/network/9606.ENSP00000255882 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate; Belongs to the PI3 [...] |
| GIMAP4 protein network | https://string-db.org/network/9606.ENSP00000255945 | GTPase IMAP family member 4; May play a role in regulating lymphocyte apoptosis (By similarity). Exhibits intrisinic GTPase activity. Shows a higher affinity for GDP over GTP (about 12-fold highe [...] |
| MKRN1 protein network | https://string-db.org/network/9606.ENSP00000255977 | E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and [...] |
| ACTR3B protein network | https://string-db.org/network/9606.ENSP00000256001 | Actin-related protein 3B; Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymeri [...] |
| NTS protein network | https://string-db.org/network/9606.ENSP00000256010 | Neurotensin/neuromedin N; Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle; Belongs to the neurotensin family |
| BTG1 protein network | https://string-db.org/network/9606.ENSP00000256015 | Protein BTG1; Anti-proliferative protein; BTG/Tob family |
| KRAS protein network | https://string-db.org/network/9606.ENSP00000256078 | GTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by induci [...] |
| IPO8 protein network | https://string-db.org/network/9606.ENSP00000256079 | Importin-8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPN [...] |
| PMP2 protein network | https://string-db.org/network/9606.ENSP00000256103 | Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family |
| FABP4 protein network | https://string-db.org/network/9606.ENSP00000256104 | Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cogna [...] |
| CCDC59 protein network | https://string-db.org/network/9606.ENSP00000256151 | Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein N [...] |
| LYVE1 protein network | https://string-db.org/network/9606.ENSP00000256178 | Lymphatic vessel endothelial hyaluronic acid receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulati [...] |
| MICALCL protein network | https://string-db.org/network/9606.ENSP00000256186 | MICAL C-terminal-like protein; May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab e [...] |
| SBF2 protein network | https://string-db.org/network/9606.ENSP00000256190 | Myotubularin-related protein 13; Guanine nucleotide exchange factor (GEF) which may activate RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their acti [...] |
| MICAL2 protein network | https://string-db.org/network/9606.ENSP00000256194 | [F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resul [...] |
| RRAS2 protein network | https://string-db.org/network/9606.ENSP00000256196 | Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect th [...] |
| TEX15 protein network | https://string-db.org/network/9606.ENSP00000256246 | Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chro [...] |
| SARAF protein network | https://string-db.org/network/9606.ENSP00000256255 | Store-operated calcium entry-associated regulatory factor; Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic [...] |
| RNF122 protein network | https://string-db.org/network/9606.ENSP00000256257 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability; Ring finger proteins |
| DUSP26 protein network | https://string-db.org/network/9606.ENSP00000256261 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kina [...] |
| C14orf1 protein network | https://string-db.org/network/9606.ENSP00000256319 | Probable ergosterol biosynthetic protein 28; Chromosome 14 open reading frame 1; Belongs to the ERG28 family |
| UNC79 protein network | https://string-db.org/network/9606.ENSP00000256339 | Protein unc-79 homolog; Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability; Belongs t [...] |
| CATSPERB protein network | https://string-db.org/network/9606.ENSP00000256343 | Cation channel sperm-associated protein subunit beta; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility wh [...] |
| VRTN protein network | https://string-db.org/network/9606.ENSP00000256362 | Vertnin; Vertebrae development associated; Belongs to the vertnin family |
| SYNJ2BP protein network | https://string-db.org/network/9606.ENSP00000256366 | Synaptojanin-2-binding protein; Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal tran [...] |
| TTC9 protein network | https://string-db.org/network/9606.ENSP00000256367 | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family |
| EIF2S1 protein network | https://string-db.org/network/9606.ENSP00000256383 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribos [...] |
| ADAM20 protein network | https://string-db.org/network/9606.ENSP00000256389 | Disintegrin and metalloproteinase domain-containing protein 20; May be involved in sperm maturation and/or fertilization; ADAM metallopeptidase domain containing |
| ELP3 protein network | https://string-db.org/network/9606.ENSP00000256398 | Elongator complex protein 3; Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is invol [...] |
| PEBP4 protein network | https://string-db.org/network/9606.ENSP00000256404 | Phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine e [...] |
| ADAMDEC1 protein network | https://string-db.org/network/9606.ENSP00000256412 | ADAM DEC1; May play an important role in the control of the immune response and during pregnancy |
| MBD2 protein network | https://string-db.org/network/9606.ENSP00000256429 | Methyl-CpG-binding domain protein 2; Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits hist [...] |
| IER3IP1 protein network | https://string-db.org/network/9606.ENSP00000256433 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By simi [...] |
| MRPS36 protein network | https://string-db.org/network/9606.ENSP00000256441 | Mitochondrial ribosomal protein S36 |
| CCNB1 protein network | https://string-db.org/network/9606.ENSP00000256442 | G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily |
| CDK7 protein network | https://string-db.org/network/9606.ENSP00000256443 | Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin- dependent kinases (CDKs) are activated by the bindin [...] |
| CD180 protein network | https://string-db.org/network/9606.ENSP00000256447 | CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/d [...] |
| IRAK2 protein network | https://string-db.org/network/9606.ENSP00000256458 | Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation [...] |
| CAMK1 protein network | https://string-db.org/network/9606.ENSP00000256460 | Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regu [...] |
| VHL protein network | https://string-db.org/network/9606.ENSP00000256474 | Von Hippel-Lindau disease tumor suppressor; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recrui [...] |
| BHLHE40 protein network | https://string-db.org/network/9606.ENSP00000256495 | Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controll [...] |
| ARL8B protein network | https://string-db.org/network/9606.ENSP00000256496 | ADP-ribosylation factor-like protein 8B; May play a role in lysosome motility. May play a role in chromosome segregation; ARF GTPase family |
| EDEM1 protein network | https://string-db.org/network/9606.ENSP00000256497 | ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved [...] |
| CHL1 protein network | https://string-db.org/network/9606.ENSP00000256509 | Neural cell adhesion molecule L1-like protein; Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membrano [...] |
| DPH6 protein network | https://string-db.org/network/9606.ENSP00000256538 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue i [...] |
| KATNBL1 protein network | https://string-db.org/network/9606.ENSP00000256544 | KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro |
| EMC7 protein network | https://string-db.org/network/9606.ENSP00000256545 | ER membrane protein complex subunit 7 |
| AMPD2 protein network | https://string-db.org/network/9606.ENSP00000256578 | AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle; Belongs to the metal [...] |
| TSHB protein network | https://string-db.org/network/9606.ENSP00000256592 | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands |
| GSTM5 protein network | https://string-db.org/network/9606.ENSP00000256593 | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Soluble glutathione S-transferases |
| GSTM3 protein network | https://string-db.org/network/9606.ENSP00000256594 | Glutathione S-transferase Mu 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous [...] |
| SORT1 protein network | https://string-db.org/network/9606.ENSP00000256637 | Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a p [...] |
| LAMTOR5 protein network | https://string-db.org/network/9606.ENSP00000256644 | Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...] |
| NOTCH2 protein network | https://string-db.org/network/9606.ENSP00000256646 | Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...] |
| TRIM45 protein network | https://string-db.org/network/9606.ENSP00000256649 | Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen- activated protein kinase signaling pathway; Ring finger proteins |
| ARF3 protein network | https://string-db.org/network/9606.ENSP00000256682 | ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may m [...] |
| SLC38A2 protein network | https://string-db.org/network/9606.ENSP00000256689 | Sodium-coupled neutral amino acid transporter 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids a [...] |
| KIDINS220 protein network | https://string-db.org/network/9606.ENSP00000256707 | Kinase D-interacting substrate of 220 kDa; Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G co [...] |
| CMPK2 protein network | https://string-db.org/network/9606.ENSP00000256722 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs [...] |
| ANO3 protein network | https://string-db.org/network/9606.ENSP00000256737 | Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signali [...] |
| FST protein network | https://string-db.org/network/9606.ENSP00000256759 | Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) |
| CFHR5 protein network | https://string-db.org/network/9606.ENSP00000256785 | Complement factor H-related protein 5; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...] |
| ERN2 protein network | https://string-db.org/network/9606.ENSP00000256797 | Serine/threonine-protein kinase/endoribonuclease IRE2; Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the [...] |
| NARS protein network | https://string-db.org/network/9606.ENSP00000256854 | Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II |
| GRP protein network | https://string-db.org/network/9606.ENSP00000256857 | Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch [...] |
| CCNH protein network | https://string-db.org/network/9606.ENSP00000256897 | Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphory [...] |
| HRH4 protein network | https://string-db.org/network/9606.ENSP00000256906 | Histamine H4 receptor; The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activit [...] |
| CABLES1 protein network | https://string-db.org/network/9606.ENSP00000256925 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activ [...] |
| DOCK2 protein network | https://string-db.org/network/9606.ENSP00000256935 | Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as [...] |
| EMP1 protein network | https://string-db.org/network/9606.ENSP00000256951 | Epithelial membrane protein 1 |
| RERG protein network | https://string-db.org/network/9606.ENSP00000256953 | Ras-related and estrogen-regulated growth inhibitor; Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduc [...] |
| SLCO1B1 protein network | https://string-db.org/network/9606.ENSP00000256958 | Solute carrier organic anion transporter family member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate [...] |
| SPX protein network | https://string-db.org/network/9606.ENSP00000256969 | Spexin; Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation wi [...] |
| DDB2 protein network | https://string-db.org/network/9606.ENSP00000256996 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA dam [...] |
| ACP2 protein network | https://string-db.org/network/9606.ENSP00000256997 | Acid phosphatase 2, lysosomal; Belongs to the histidine acid phosphatase family |
| FOLH1 protein network | https://string-db.org/network/9606.ENSP00000256999 | Glutamate carboxypeptidase 2; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestin [...] |
| FAM127A protein network | https://string-db.org/network/9606.ENSP00000257013 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member A; Belongs to the FAM127 family |
| RAB33A protein network | https://string-db.org/network/9606.ENSP00000257017 | Ras-related protein Rab-33A; RAB33A, member RAS oncogene family |
| MTNR1B protein network | https://string-db.org/network/9606.ENSP00000257068 | Melatonin receptor type 1B; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis tox [...] |
| PHC2 protein network | https://string-db.org/network/9606.ENSP00000257118 | Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| ZCCHC11 protein network | https://string-db.org/network/9606.ENSP00000257177 | Terminal uridylyltransferase 4; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Invo [...] |
| PRPF38A protein network | https://string-db.org/network/9606.ENSP00000257181 | Pre-mRNA-splicing factor 38A; May be required for pre-mRNA splicing; Belongs to the PRP38 family |
| DSG3 protein network | https://string-db.org/network/9606.ENSP00000257189 | Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins |
| DSG1 protein network | https://string-db.org/network/9606.ENSP00000257192 | Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins |
| DSC1 protein network | https://string-db.org/network/9606.ENSP00000257198 | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...] |
| DAGLA protein network | https://string-db.org/network/9606.ENSP00000257215 | Sn1-specific diacylglycerol lipase alpha; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal gr [...] |
| TIMM10 protein network | https://string-db.org/network/9606.ENSP00000257245 | Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mi [...] |
| GIF protein network | https://string-db.org/network/9606.ENSP00000257248 | Gastric intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated e [...] |
| TCN1 protein network | https://string-db.org/network/9606.ENSP00000257264 | Transcobalamin-1; Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach; Belongs to the eukaryotic cobalamin transport proteins family |
| CEP135 protein network | https://string-db.org/network/9606.ENSP00000257287 | Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole sate [...] |
| PDGFRA protein network | https://string-db.org/network/9606.ENSP00000257290 | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic d [...] |
| DZIP1 protein network | https://string-db.org/network/9606.ENSP00000257312 | Zinc finger protein DZIP1; May participate in spermatogenesis via its interaction with DAZ. Has a role in primary cilium formation; Belongs to the DZIP C2H2-type zinc-finger protein family |
| BIVM protein network | https://string-db.org/network/9606.ENSP00000257336 | Basic, immunoglobulin-like variable motif containing |
| CARS2 protein network | https://string-db.org/network/9606.ENSP00000257347 | Probable cysteine--tRNA ligase, mitochondrial; cysteinyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family |
| ADAMTS8 protein network | https://string-db.org/network/9606.ENSP00000257359 | A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties; ADAM metallopeptidases with thrombospondin type 1 motif |
| KLB protein network | https://string-db.org/network/9606.ENSP00000257408 | Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increa [...] |
| SEMA6A protein network | https://string-db.org/network/9606.ENSP00000257414 | Semaphorin-6A; Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganizati [...] |
| APC protein network | https://string-db.org/network/9606.ENSP00000257430 | Adenomatous polyposis coli protein; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphory [...] |
| FAM189A2 protein network | https://string-db.org/network/9606.ENSP00000257515 | Protein FAM189A2; Family with sequence similarity 189 member A2 |
| ADAM19 protein network | https://string-db.org/network/9606.ENSP00000257527 | Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, [...] |
| USP30 protein network | https://string-db.org/network/9606.ENSP00000257548 | Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRK [...] |
| SDS protein network | https://string-db.org/network/9606.ENSP00000257549 | L-serine dehydratase/L-threonine deaminase; Serine dehydratase |
| MSI1 protein network | https://string-db.org/network/9606.ENSP00000257552 | RNA-binding protein Musashi homolog 1; RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA co [...] |
| HNF1A protein network | https://string-db.org/network/9606.ENSP00000257555 | Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Required for the e [...] |
| TBX3 protein network | https://string-db.org/network/9606.ENSP00000257566 | T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in ce [...] |
| OASL protein network | https://string-db.org/network/9606.ENSP00000257570 | 2'-5'-oligoadenylate synthase-like protein; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatiti [...] |
| HRK protein network | https://string-db.org/network/9606.ENSP00000257572 | Activator of apoptosis harakiri; Promotes apoptosis; BCL2 homology region 3 only |
| RNFT2 protein network | https://string-db.org/network/9606.ENSP00000257575 | Ring finger protein, transmembrane 2 |
| DTX1 protein network | https://string-db.org/network/9606.ENSP00000257600 | E3 ubiquitin-protein ligase DTX1; Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway v [...] |
| TRAFD1 protein network | https://string-db.org/network/9606.ENSP00000257604 | TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like heli [...] |
| GSAP protein network | https://string-db.org/network/9606.ENSP00000257626 | Gamma-secretase-activating protein; Regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42 [...] |
| OCM2 protein network | https://string-db.org/network/9606.ENSP00000257627 | Putative oncomodulin-2; EF-hand domain containing; Belongs to the parvalbumin family |
| UPK3B protein network | https://string-db.org/network/9606.ENSP00000257632 | Uroplakin-3b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoske [...] |
| TMEM60 protein network | https://string-db.org/network/9606.ENSP00000257663 | Transmembrane protein 60 |
| HILPDA protein network | https://string-db.org/network/9606.ENSP00000257696 | Hypoxia-inducible lipid droplet-associated protein; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and prolifera [...] |
| RINT1 protein network | https://string-db.org/network/9606.ENSP00000257700 | RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ comp [...] |
| BACH2 protein network | https://string-db.org/network/9606.ENSP00000257749 | Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important [...] |
| NT5E protein network | https://string-db.org/network/9606.ENSP00000257770 | 5'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities; Belongs to the 5'-nucleotidase family |
| MRAP2 protein network | https://string-db.org/network/9606.ENSP00000257776 | Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and [...] |
| AKIRIN2 protein network | https://string-db.org/network/9606.ENSP00000257787 | Akirin-2; Required for the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6. Forms a complex wit [...] |
| ORC3 protein network | https://string-db.org/network/9606.ENSP00000257789 | Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...] |
| LMO2 protein network | https://string-db.org/network/9606.ENSP00000257818 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state; LIM domain containing |
| NAT10 protein network | https://string-db.org/network/9606.ENSP00000257829 | RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1337 and 1842 in [...] |
| PRRG4 protein network | https://string-db.org/network/9606.ENSP00000257836 | Transmembrane gamma-carboxyglutamic acid protein 4; Proline rich and Gla domain containing |
| PRPH protein network | https://string-db.org/network/9606.ENSP00000257860 | Peripherin; Class-III neuronal intermediate filament protein |
| AVIL protein network | https://string-db.org/network/9606.ENSP00000257861 | Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outg [...] |
| AMHR2 protein network | https://string-db.org/network/9606.ENSP00000257863 | Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphoryla [...] |
| LACRT protein network | https://string-db.org/network/9606.ENSP00000257867 | Extracellular glycoprotein lacritin; Modulates secretion by lacrimal acinar cells |
| GDF11 protein network | https://string-db.org/network/9606.ENSP00000257868 | Growth/differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning bot [...] |
| FAM186B protein network | https://string-db.org/network/9606.ENSP00000257894 | Protein FAM186B; Family with sequence similarity 186 member B |
| RDH5 protein network | https://string-db.org/network/9606.ENSP00000257895 | 11-cis retinol dehydrogenase; Stereospecific 11-cis retinol dehydrogenase, which catalyzes the final step in the biosynthesis of 11-cis retinaldehyde, the universal chromophore of visual pigments [...] |
| KRT85 protein network | https://string-db.org/network/9606.ENSP00000257901 | Keratin, type II cuticular Hb5; Keratins, type II |
| CDK4 protein network | https://string-db.org/network/9606.ENSP00000257904 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the [...] |
| PPP1R1A protein network | https://string-db.org/network/9606.ENSP00000257905 | Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP [...] |
| TROAP protein network | https://string-db.org/network/9606.ENSP00000257909 | Tastin; Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo [...] |
| TSPAN31 protein network | https://string-db.org/network/9606.ENSP00000257910 | Tetraspanin-31; Tetraspanin 31; Tetraspanins |
| TFCP2 protein network | https://string-db.org/network/9606.ENSP00000257915 | Alpha-globin transcription factor CP2; Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in ery [...] |
| ESPL1 protein network | https://string-db.org/network/9606.ENSP00000257934 | Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cel [...] |
| ZC3H10 protein network | https://string-db.org/network/9606.ENSP00000257940 | Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1-type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and [...] |
| KRT84 protein network | https://string-db.org/network/9606.ENSP00000257951 | Keratin, type II cuticular Hb4; Keratins, type II |
| KRT82 protein network | https://string-db.org/network/9606.ENSP00000257974 | Keratin, type II cuticular Hb2; Keratins, type II |
| MIP protein network | https://string-db.org/network/9606.ENSP00000257979 | Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the [...] |
| KCNH3 protein network | https://string-db.org/network/9606.ENSP00000257981 | Potassium voltage-gated channel subfamily H member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be [...] |
| TAAR5 protein network | https://string-db.org/network/9606.ENSP00000258034 | Trace amine-associated receptor 5; Olfactory receptor specific for trimethylamine, a trace amine. Also activated at lower level by dimethylethylamine. Trimethylamine is a bacterial metabolite fou [...] |
| NMBR protein network | https://string-db.org/network/9606.ENSP00000258042 | Neuromedin-B receptor; Receptor for neuromedin-B; Bombesin receptors |
| SMPD2 protein network | https://string-db.org/network/9606.ENSP00000258052 | Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-plate [...] |
| HTRA2 protein network | https://string-db.org/network/9606.ENSP00000258080 | Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and [...] |
| PRADC1 protein network | https://string-db.org/network/9606.ENSP00000258083 | Protease-associated domain-containing protein 1; Protease associated domain containing 1 |
| CCT7 protein network | https://string-db.org/network/9606.ENSP00000258091 | T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); Cha [...] |
| RAB11FIP5 protein network | https://string-db.org/network/9606.ENSP00000258098 | Rab11 family-interacting protein 5; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulat [...] |
| MRPL53 protein network | https://string-db.org/network/9606.ENSP00000258105 | Mitochondrial ribosomal protein L53 |
| EMX1 protein network | https://string-db.org/network/9606.ENSP00000258106 | Homeobox protein EMX1; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations [...] |
| KCNMB4 protein network | https://string-db.org/network/9606.ENSP00000258111 | Calcium-activated potassium channel subunit beta-4; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...] |
| GNS protein network | https://string-db.org/network/9606.ENSP00000258145 | N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; Belongs to the sulfatase family |
| MDM2 protein network | https://string-db.org/network/9606.ENSP00000258149 | E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell [...] |
| BCO1 protein network | https://string-db.org/network/9606.ENSP00000258168 | Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family |
| MPHOSPH6 protein network | https://string-db.org/network/9606.ENSP00000258169 | M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiti [...] |
| TMEM231 protein network | https://string-db.org/network/9606.ENSP00000258173 | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of tra [...] |
| DYNC1LI2 protein network | https://string-db.org/network/9606.ENSP00000258198 | Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to [...] |
| FBXL8 protein network | https://string-db.org/network/9606.ENSP00000258200 | F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| FHOD1 protein network | https://string-db.org/network/9606.ENSP00000258201 | FH1/FH2 domain-containing protein 1; Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of m [...] |
| CCDC102A protein network | https://string-db.org/network/9606.ENSP00000258214 | Coiled-coil domain containing 102A |
| PCNXL2 protein network | https://string-db.org/network/9606.ENSP00000258229 | Pecanex-like protein 2; May play a role in tumorigenesis of colorectal carcinomas with high microsatellite instability (MSI-H); Belongs to the pecanex family |
| URB2 protein network | https://string-db.org/network/9606.ENSP00000258243 | URB2 ribosome biogenesis 2 homolog |
| TAF5L protein network | https://string-db.org/network/9606.ENSP00000258281 | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating hi [...] |
| STX6 protein network | https://string-db.org/network/9606.ENSP00000258301 | Syntaxin-6; Involved in intracellular vesicle trafficking; Syntaxins |
| RGS8 protein network | https://string-db.org/network/9606.ENSP00000258302 | Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similar [...] |
| NPL protein network | https://string-db.org/network/9606.ENSP00000258317 | N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from b [...] |
| LAMC1 protein network | https://string-db.org/network/9606.ENSP00000258341 | Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| SP110 protein network | https://string-db.org/network/9606.ENSP00000258381 | Sp110 nuclear body protein; Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE); Bromodomain containin [...] |
| MRPL44 protein network | https://string-db.org/network/9606.ENSP00000258383 | 39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the r [...] |
| CHRND protein network | https://string-db.org/network/9606.ENSP00000258385 | Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...] |
| DOCK10 protein network | https://string-db.org/network/9606.ENSP00000258390 | Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Pu [...] |
| USP37 protein network | https://string-db.org/network/9606.ENSP00000258399 | Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2) [...] |
| HTR2B protein network | https://string-db.org/network/9606.ENSP00000258400 | 5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. L [...] |
| SLC19A3 protein network | https://string-db.org/network/9606.ENSP00000258403 | Thiamine transporter 2; Mediates high affinity thiamine uptake, probably via a proton anti-port mechanism. Has no folate transport activity; Belongs to the reduced folate carrier (RFC) transporte [...] |
| WNT10A protein network | https://string-db.org/network/9606.ENSP00000258411 | Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to [...] |
| CYP27A1 protein network | https://string-db.org/network/9606.ENSP00000258415 | Sterol 26-hydroxylase, mitochondrial; Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-trio [...] |
| EIF4E2 protein network | https://string-db.org/network/9606.ENSP00000258416 | Eukaryotic translation initiation factor 4E type 2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initi [...] |
| CAB39 protein network | https://string-db.org/network/9606.ENSP00000258418 | Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25bet [...] |
| COX5B protein network | https://string-db.org/network/9606.ENSP00000258424 | Cytochrome c oxidase subunit 5B, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| REV1 protein network | https://string-db.org/network/9606.ENSP00000258428 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the firs [...] |
| MFSD9 protein network | https://string-db.org/network/9606.ENSP00000258436 | Major facilitator superfamily domain containing 9 |
| TMEM127 protein network | https://string-db.org/network/9606.ENSP00000258439 | Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor |
| EDAR protein network | https://string-db.org/network/9606.ENSP00000258443 | Tumor necrosis factor receptor superfamily member EDAR; Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cel [...] |
| MRPS9 protein network | https://string-db.org/network/9606.ENSP00000258455 | Mitochondrial ribosomal protein S9 |
| GPR45 protein network | https://string-db.org/network/9606.ENSP00000258456 | Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function; G protein-coupled receptors, Class A orphans |
| C2orf49 protein network | https://string-db.org/network/9606.ENSP00000258457 | Ashwin; Chromosome 2 open reading frame 49; Belongs to the ashwin family |
| EPC2 protein network | https://string-db.org/network/9606.ENSP00000258484 | Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair |
| ALDH1L2 protein network | https://string-db.org/network/9606.ENSP00000258494 | Mitochondrial 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L2; In the N-terminal section; belongs to the GART family |
| USP44 protein network | https://string-db.org/network/9606.ENSP00000258499 | Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by [...] |
| PLXNC1 protein network | https://string-db.org/network/9606.ENSP00000258526 | Plexin-C1; Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the re [...] |
| DRAM1 protein network | https://string-db.org/network/9606.ENSP00000258534 | DNA damage-regulated autophagy modulator protein 1; Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy |
| SLC41A2 protein network | https://string-db.org/network/9606.ENSP00000258538 | Solute carrier family 41 member 2; Acts as a plasma-membrane magnesium transporter; Solute carriers |
| THSD1 protein network | https://string-db.org/network/9606.ENSP00000258613 | Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1 |
| MED4 protein network | https://string-db.org/network/9606.ENSP00000258648 | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| COG3 protein network | https://string-db.org/network/9606.ENSP00000258654 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport; Belongs to the COG3 family |
| NUDT15 protein network | https://string-db.org/network/9606.ENSP00000258662 | Nucleotide triphosphate diphosphatase NUDT15; May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine d [...] |
| SPDYE1 protein network | https://string-db.org/network/9606.ENSP00000258704 | Speedy protein E1; speedy/RINGO cell cycle regulator family member E1 |
| IGF2BP3 protein network | https://string-db.org/network/9606.ENSP00000258729 | Insulin-like growth factor 2 mRNA-binding protein 3; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allow [...] |
| KDELR2 protein network | https://string-db.org/network/9606.ENSP00000258739 | ER lumen protein-retaining receptor 2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required f [...] |
| NUPL2 protein network | https://string-db.org/network/9606.ENSP00000258742 | Nucleoporin-like protein 2; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. In case of infection by HIV-1, it may participate in the docking of vira [...] |
| TBRG4 protein network | https://string-db.org/network/9606.ENSP00000258770 | Protein TBRG4; May play a role in cell cycle progression; FASTK mitochondrial RNA binding family |
| DDX56 protein network | https://string-db.org/network/9606.ENSP00000258772 | Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre-ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity [...] |
| HUS1 protein network | https://string-db.org/network/9606.ENSP00000258774 | Checkpoint protein HUS1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17 [...] |
| C7orf69 protein network | https://string-db.org/network/9606.ENSP00000258776 | Uncharacterized protein C7orf69; Chromosome 7 open reading frame 69 |
| MYO1G protein network | https://string-db.org/network/9606.ENSP00000258787 | Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T- cell migration. Unconventional myosins are actin-ba [...] |
| TTYH3 protein network | https://string-db.org/network/9606.ENSP00000258796 | Protein tweety homolog 3; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction; Belongs to the tweety family |
| TTC5 protein network | https://string-db.org/network/9606.ENSP00000258821 | Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interac [...] |
| NKX2-8 protein network | https://string-db.org/network/9606.ENSP00000258829 | Homeobox protein Nkx-2.8; NKL subclass homeoboxes and pseudogenes |
| ACSBG1 protein network | https://string-db.org/network/9606.ENSP00000258873 | Long-chain-fatty-acid--CoA ligase ACSBG1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatt [...] |
| MTHFS protein network | https://string-db.org/network/9606.ENSP00000258874 | 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for th [...] |
| ABHD17C protein network | https://string-db.org/network/9606.ENSP00000258884 | Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95. |
| IREB2 protein network | https://string-db.org/network/9606.ENSP00000258886 | Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'- UTR of ferritin, and delta aminolevul [...] |
| ALPK3 protein network | https://string-db.org/network/9606.ENSP00000258888 | Alpha-protein kinase 3; Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Plays a role in cardiomyocyte differentiation (By simila [...] |
| CIB2 protein network | https://string-db.org/network/9606.ENSP00000258930 | Calcium and integrin-binding family member 2; Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreas [...] |
| RSAD1 protein network | https://string-db.org/network/9606.ENSP00000258955 | Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; May be involved in porphyrin cofactor biosynthesis; Belongs to the anaerobic coproporphyrinogen-III oxidase family |
| SRSF1 protein network | https://string-db.org/network/9606.ENSP00000258962 | Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal componen [...] |
| TACO1 protein network | https://string-db.org/network/9606.ENSP00000258975 | Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially- encoded cytochrome c oxidase 1; Belongs to the TACO1 family |
| TEX2 protein network | https://string-db.org/network/9606.ENSP00000258991 | Testis-expressed protein 2; Testis expressed 2 |
| LIMD2 protein network | https://string-db.org/network/9606.ENSP00000259006 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility; LIM domain containing |
| BRIP1 protein network | https://string-db.org/network/9606.ENSP00000259008 | Fanconi anemia group J protein; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquit [...] |
| KAT7 protein network | https://string-db.org/network/9606.ENSP00000259021 | Histone acetyltransferase KAT7; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of [...] |
| RTP4 protein network | https://string-db.org/network/9606.ENSP00000259030 | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional e [...] |
| NDUFB5 protein network | https://string-db.org/network/9606.ENSP00000259037 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...] |
| MARCH7 protein network | https://string-db.org/network/9606.ENSP00000259050 | E3 ubiquitin-protein ligase MARCH7; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzy [...] |
| CD302 protein network | https://string-db.org/network/9606.ENSP00000259053 | CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration |
| GALNT5 protein network | https://string-db.org/network/9606.ENSP00000259056 | Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| BLK protein network | https://string-db.org/network/9606.ENSP00000259089 | Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of sever [...] |
| KCTD3 protein network | https://string-db.org/network/9606.ENSP00000259154 | BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and c [...] |
| CBWD2 protein network | https://string-db.org/network/9606.ENSP00000259199 | COBW domain containing 2; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily |
| IL36G protein network | https://string-db.org/network/9606.ENSP00000259205 | Interleukin-36 gamma; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signa [...] |
| IL1RN protein network | https://string-db.org/network/9606.ENSP00000259206 | Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no inte [...] |
| IL36A protein network | https://string-db.org/network/9606.ENSP00000259211 | Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflamma [...] |
| IL36B protein network | https://string-db.org/network/9606.ENSP00000259213 | Interleukin-36 beta; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammat [...] |
| CFC1 protein network | https://string-db.org/network/9606.ENSP00000259216 | Cryptic protein; NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm and/or neural patterning during gastrulation; Belongs to the EGF-CFC (C [...] |
| CCDC115 protein network | https://string-db.org/network/9606.ENSP00000259229 | Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, requi [...] |
| IMP4 protein network | https://string-db.org/network/9606.ENSP00000259239 | U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processi [...] |
| HS6ST1 protein network | https://string-db.org/network/9606.ENSP00000259241 | Heparan-sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...] |
| UGGT1 protein network | https://string-db.org/network/9606.ENSP00000259253 | UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality [...] |
| GYPC protein network | https://string-db.org/network/9606.ENSP00000259254 | Glycophorin-C; This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely locate [...] |
| LRRC8A protein network | https://string-db.org/network/9606.ENSP00000259324 | Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell vo [...] |
| KIAA0368 protein network | https://string-db.org/network/9606.ENSP00000259335 | Proteasome-associated protein ECM29 homolog; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to dif [...] |
| TOR1B protein network | https://string-db.org/network/9606.ENSP00000259339 | Torsin-1B; May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non-neural cells nuclear envelope and endoplasmic reticulum int [...] |
| RALGPS1 protein network | https://string-db.org/network/9606.ENSP00000259351 | Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine [...] |
| OR1J1 protein network | https://string-db.org/network/9606.ENSP00000259357 | Olfactory receptor 1J1; Odorant receptor; Olfactory receptors, family 1 |
| OR13C9 protein network | https://string-db.org/network/9606.ENSP00000259362 | Olfactory receptor 13C9; Odorant receptor; Olfactory receptors, family 13 |
| TMOD1 protein network | https://string-db.org/network/9606.ENSP00000259365 | Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...] |
| DAB2IP protein network | https://string-db.org/network/9606.ENSP00000259371 | Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several pr [...] |
| SLC31A2 protein network | https://string-db.org/network/9606.ENSP00000259392 | Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake; Solute carriers |
| ORM1 protein network | https://string-db.org/network/9606.ENSP00000259396 | Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their d [...] |
| STX17 protein network | https://string-db.org/network/9606.ENSP00000259400 | Syntaxin-17; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assem [...] |
| BAAT protein network | https://string-db.org/network/9606.ENSP00000259407 | Bile acid-CoA:amino acid N-acyltransferase; Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taur [...] |
| GABBR2 protein network | https://string-db.org/network/9606.ENSP00000259455 | Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABB [...] |
| PSMB7 protein network | https://string-db.org/network/9606.ENSP00000259457 | Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| OR1L4 protein network | https://string-db.org/network/9606.ENSP00000259466 | Olfactory receptor 1L4; Odorant receptor; Olfactory receptors, family 1 |
| PDCL protein network | https://string-db.org/network/9606.ENSP00000259467 | Phosducin-like protein; Isoform 1: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodi [...] |
| RPL35 protein network | https://string-db.org/network/9606.ENSP00000259469 | 60S ribosomal protein L35; Component of the large ribosomal subunit |
| ENPP2 protein network | https://string-db.org/network/9606.ENSP00000259486 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylc [...] |
| DERL1 protein network | https://string-db.org/network/9606.ENSP00000259512 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded [...] |
| NOV protein network | https://string-db.org/network/9606.ENSP00000259526 | Protein NOV homolog; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins [...] |
| RANBP6 protein network | https://string-db.org/network/9606.ENSP00000259569 | Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Armadillo-like helical domain containing |
| RNF38 protein network | https://string-db.org/network/9606.ENSP00000259605 | E3 ubiquitin-protein ligase RNF38; Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhi [...] |
| CCL21 protein network | https://string-db.org/network/9606.ENSP00000259607 | C-C motif chemokine 21; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Shows preferen [...] |
| SIT1 protein network | https://string-db.org/network/9606.ENSP00000259608 | Signaling threshold-regulating transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells. Involved in positive selection of T-cells |
| CCL27 protein network | https://string-db.org/network/9606.ENSP00000259631 | C-C motif chemokine 27; Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10; Belongs to th [...] |
| DCTN3 protein network | https://string-db.org/network/9606.ENSP00000259632 | Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis; Dynactin |
| HINT2 protein network | https://string-db.org/network/9606.ENSP00000259667 | Histidine triad nucleotide-binding protein 2, mitochondrial; Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity; Belongs to [...] |
| KLC4 protein network | https://string-db.org/network/9606.ENSP00000259708 | Kinesin light chain 4; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...] |
| KIF13A protein network | https://string-db.org/network/9606.ENSP00000259711 | Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) [...] |
| GMPR protein network | https://string-db.org/network/9606.ENSP00000259727 | GMP reductase 1; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, a [...] |
| TMEM63B protein network | https://string-db.org/network/9606.ENSP00000259746 | CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel |
| TTBK1 protein network | https://string-db.org/network/9606.ENSP00000259750 | Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU; Belongs to the protein kinase superfamily. [...] |
| TINAG protein network | https://string-db.org/network/9606.ENSP00000259782 | Tubulointerstitial nephritis antigen; Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein |
| GCM1 protein network | https://string-db.org/network/9606.ENSP00000259803 | Chorion-specific transcription factor GCMa; Transcription factor involved in the control of expression of placental growth factor (PGF) and other placenta- specific genes. Binds to the trophoblas [...] |
| FOXF2 protein network | https://string-db.org/network/9606.ENSP00000259806 | Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes; Forkhead boxes |
| RIPK1 protein network | https://string-db.org/network/9606.ENSP00000259808 | Receptor-interacting serine/threonine-protein kinase 1; Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, acti [...] |
| TUBB2B protein network | https://string-db.org/network/9606.ENSP00000259818 | Tubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...] |
| PSORS1C2 protein network | https://string-db.org/network/9606.ENSP00000259845 | Psoriasis susceptibility 1 candidate 2 |
| C6orf15 protein network | https://string-db.org/network/9606.ENSP00000259870 | Uncharacterized protein C6orf15; Chromosome 6 open reading frame 15 |
| MRPS18B protein network | https://string-db.org/network/9606.ENSP00000259873 | Mitochondrial ribosomal protein S18B; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily |
| IER3 protein network | https://string-db.org/network/9606.ENSP00000259874 | Radiation-inducible immediate-early gene IEX-1; May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A- PPP2R5C holoenzyme. Acts also as an ER [...] |
| PSORS1C1 protein network | https://string-db.org/network/9606.ENSP00000259881 | Psoriasis susceptibility 1 candidate 1 |
| PGBD1 protein network | https://string-db.org/network/9606.ENSP00000259883 | PiggyBac transposable element-derived protein 1; Scavenger receptor cysteine rich domain containing; DNA transposon derived genes |
| GTF2H4 protein network | https://string-db.org/network/9606.ENSP00000259895 | General transcription factor IIH subunit 4; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcrip [...] |
| POU5F1 protein network | https://string-db.org/network/9606.ENSP00000259915 | POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a numb [...] |
| CLPS protein network | https://string-db.org/network/9606.ENSP00000259938 | Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an i [...] |
| RNF144B protein network | https://string-db.org/network/9606.ENSP00000259939 | E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly trans [...] |
| HLA-F protein network | https://string-db.org/network/9606.ENSP00000259951 | HLA class I histocompatibility antigen, alpha chain F; Involved in the presentation of foreign antigens to the immune system; C1-set domain containing |
| NRM protein network | https://string-db.org/network/9606.ENSP00000259953 | Nurim |
| FAM8A1 protein network | https://string-db.org/network/9606.ENSP00000259963 | Protein FAM8A1; Family with sequence similarity 8 member A1 |
| C6orf52 protein network | https://string-db.org/network/9606.ENSP00000259983 | Putative uncharacterized protein C6orf52; Chromosome 6 open reading frame 52 |
| FGFBP2 protein network | https://string-db.org/network/9606.ENSP00000259989 | Fibroblast growth factor binding protein 2 |
| TLR2 protein network | https://string-db.org/network/9606.ENSP00000260010 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the in [...] |
| PRKRIR protein network | https://string-db.org/network/9606.ENSP00000260045 | 52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of DNAJC3, result [...] |
| MRPL15 protein network | https://string-db.org/network/9606.ENSP00000260102 | Mitochondrial ribosomal protein L15 |
| PI15 protein network | https://string-db.org/network/9606.ENSP00000260113 | Peptidase inhibitor 15; Serine protease inhibitor which displays weak inhibitory activity against trypsin. May play a role in facial patterning during embryonic development (By similarity); Belon [...] |
| TTPA protein network | https://string-db.org/network/9606.ENSP00000260116 | Alpha-tocopherol transfer protein; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosph [...] |
| GGH protein network | https://string-db.org/network/9606.ENSP00000260118 | Gamma-glutamyl hydrolase; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- [...] |
| SLCO5A1 protein network | https://string-db.org/network/9606.ENSP00000260126 | Solute carrier organic anion transporter family member 5A1; Belongs to the organo anion transporter (TC 2.A.60) family |
| SULF1 protein network | https://string-db.org/network/9606.ENSP00000260128 | Extracellular sulfatase Sulf-1; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specifi [...] |
| TGS1 protein network | https://string-db.org/network/9606.ENSP00000260129 | Trimethylguanosine synthase; Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) [...] |
| SDCBP protein network | https://string-db.org/network/9606.ENSP00000260130 | Syntenin-1; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenes [...] |
| DDX60L protein network | https://string-db.org/network/9606.ENSP00000260184 | Probable ATP-dependent RNA helicase DDX60-like; Ski2 like RNA helicases; Belongs to the helicase family |
| USP2 protein network | https://string-db.org/network/9606.ENSP00000260187 | Ubiquitin carboxyl-terminal hydrolase 2; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific pep [...] |
| HTR3B protein network | https://string-db.org/network/9606.ENSP00000260191 | 5-hydroxytryptamine receptor 3B; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| SORL1 protein network | https://string-db.org/network/9606.ENSP00000260197 | Sortilin-related receptor; Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipo [...] |
| BUD13 protein network | https://string-db.org/network/9606.ENSP00000260210 | BUD13 homolog; Spliceosomal P complex; Belongs to the CWC26 family |
| MMP7 protein network | https://string-db.org/network/9606.ENSP00000260227 | Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase; M10 matrix metallopeptidases |
| MMP20 protein network | https://string-db.org/network/9606.ENSP00000260228 | Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and th [...] |
| MMP27 protein network | https://string-db.org/network/9606.ENSP00000260229 | Matrix metalloproteinase-27; Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens; M10 matrix metallopeptidases |
| DCUN1D5 protein network | https://string-db.org/network/9606.ENSP00000260247 | DCN1-like protein 5; Defective in cullin neddylation 1 domain containing 5 |
| FDXACB1 protein network | https://string-db.org/network/9606.ENSP00000260257 | Ferredoxin-fold anticodon-binding domain-containing protein 1; Ferredoxin-fold anticodon binding domain containing 1 |
| POU2F3 protein network | https://string-db.org/network/9606.ENSP00000260264 | POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Regulated the expression of a number of genes such as SPRR2A or placental lacto [...] |
| FDX1 protein network | https://string-db.org/network/9606.ENSP00000260270 | Adrenodoxin, mitochondrial; Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P [...] |
| C11orf1 protein network | https://string-db.org/network/9606.ENSP00000260276 | UPF0686 protein C11orf1; Chromosome 11 open reading frame 1; Belongs to the UPF0686 family |
| ARHGAP20 protein network | https://string-db.org/network/9606.ENSP00000260283 | Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state |
| MMP13 protein network | https://string-db.org/network/9606.ENSP00000260302 | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type I [...] |
| UNC13C protein network | https://string-db.org/network/9606.ENSP00000260323 | Protein unc-13 homolog C; May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmi [...] |
| SQRDL protein network | https://string-db.org/network/9606.ENSP00000260324 | Sulfide:quinone oxidoreductase, mitochondrial; Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (mo [...] |
| CTDSPL2 protein network | https://string-db.org/network/9606.ENSP00000260327 | CTD small phosphatase-like protein 2; Probable phosphatase; CTD family phosphatases |
| THBS1 protein network | https://string-db.org/network/9606.ENSP00000260356 | Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp ( [...] |
| NDUFAF1 protein network | https://string-db.org/network/9606.ENSP00000260361 | Complex I intermediate-associated protein 30, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I); Belongs to the CIA [...] |
| KIF23 protein network | https://string-db.org/network/9606.ENSP00000260363 | Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during th [...] |
| HAUS2 protein network | https://string-db.org/network/9606.ENSP00000260372 | HAUS augmin-like complex subunit 2; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| TUBGCP4 protein network | https://string-db.org/network/9606.ENSP00000260383 | Gamma-tubulin complex component 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome |
| RMDN3 protein network | https://string-db.org/network/9606.ENSP00000260385 | Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptos [...] |
| ITPKA protein network | https://string-db.org/network/9606.ENSP00000260386 | Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family |
| PLCB2 protein network | https://string-db.org/network/9606.ENSP00000260402 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...] |
| TMEM62 protein network | https://string-db.org/network/9606.ENSP00000260403 | Transmembrane protein 62 |
| ADAM10 protein network | https://string-db.org/network/9606.ENSP00000260408 | Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytica [...] |
| BCL2L10 protein network | https://string-db.org/network/9606.ENSP00000260442 | Bcl-2-like protein 10; Promotes cell survival. Suppresses apoptosis induced by BAX but not BAK; BCL2 family |
| RSL24D1 protein network | https://string-db.org/network/9606.ENSP00000260443 | Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity); Belongs to the eukary [...] |
| GCHFR protein network | https://string-db.org/network/9606.ENSP00000260447 | GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine |
| MNS1 protein network | https://string-db.org/network/9606.ENSP00000260453 | Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis |
| TTLL7 protein network | https://string-db.org/network/9606.ENSP00000260505 | Tubulin polyglutamylase TTLL7; Polyglutamylase which preferentially modifies beta- tubulin. Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules. Required fo [...] |
| CCBL2 protein network | https://string-db.org/network/9606.ENSP00000260508 | Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S [...] |
| ARHGAP29 protein network | https://string-db.org/network/9606.ENSP00000260526 | Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and [...] |
| RTCA protein network | https://string-db.org/network/9606.ENSP00000260563 | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adeny [...] |
| IFT172 protein network | https://string-db.org/network/9606.ENSP00000260570 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the [...] |
| EPT1 protein network | https://string-db.org/network/9606.ENSP00000260585 | Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. I [...] |
| KHK protein network | https://string-db.org/network/9606.ENSP00000260599 | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate; Belongs to the carbohydrate kinase PfkB family |
| ADCY3 protein network | https://string-db.org/network/9606.ENSP00000260600 | Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its func [...] |
| PREB protein network | https://string-db.org/network/9606.ENSP00000260643 | Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat compon [...] |
| ABCG5 protein network | https://string-db.org/network/9606.ENSP00000260645 | ATP-binding cassette sub-family G member 5; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role [...] |
| SLC3A1 protein network | https://string-db.org/network/9606.ENSP00000260649 | Neutral and basic amino acid transport protein rBAT; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May [...] |
| SIX3 protein network | https://string-db.org/network/9606.ENSP00000260653 | Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. Dur [...] |
| LRPPRC protein network | https://string-db.org/network/9606.ENSP00000260665 | Leucine-rich PPR motif-containing protein, mitochondrial; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of [...] |
| CYP2C9 protein network | https://string-db.org/network/9606.ENSP00000260682 | Cytochrome P450 2C9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| LOXL4 protein network | https://string-db.org/network/9606.ENSP00000260702 | Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix; Scavenger receptor cysteine rich domain containing |
| BTBD16 protein network | https://string-db.org/network/9606.ENSP00000260723 | BTB/POZ domain-containing protein 16; BTB domain containing 16 |
| KIF11 protein network | https://string-db.org/network/9606.ENSP00000260731 | Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to t [...] |
| CALHM2 protein network | https://string-db.org/network/9606.ENSP00000260743 | Calcium homeostasis modulator protein 2; Pore-forming subunit of a voltage-gated ion channel; Calcium homeostasis modulators |
| ARL3 protein network | https://string-db.org/network/9606.ENSP00000260746 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleoti [...] |
| EXOC6 protein network | https://string-db.org/network/9606.ENSP00000260762 | Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PR [...] |
| DBR1 protein network | https://string-db.org/network/9606.ENSP00000260803 | Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently deg [...] |
| TOPBP1 protein network | https://string-db.org/network/9606.ENSP00000260810 | DNA topoisomerase 2-binding protein 1; Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double- stranded DNA breaks and nicks as [...] |
| DNAJC13 protein network | https://string-db.org/network/9606.ENSP00000260818 | DnaJ homolog subfamily C member 13; Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin [...] |
| GPR87 protein network | https://string-db.org/network/9606.ENSP00000260843 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage; Belongs to the G-protein coupled receptor 1 family |
| BARD1 protein network | https://string-db.org/network/9606.ENSP00000260947 | BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diver [...] |
| MSTN protein network | https://string-db.org/network/9606.ENSP00000260950 | Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family |
| ASNSD1 protein network | https://string-db.org/network/9606.ENSP00000260952 | Asparagine synthetase domain containing 1 |
| METTL5 protein network | https://string-db.org/network/9606.ENSP00000260953 | Methyltransferase-like protein 5; Probable methyltransferase |
| PPIG protein network | https://string-db.org/network/9606.ENSP00000260970 | Peptidyl-prolyl cis-trans isomerase G; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in [...] |
| HECW2 protein network | https://string-db.org/network/9606.ENSP00000260983 | E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regula [...] |
| CRYGB protein network | https://string-db.org/network/9606.ENSP00000260988 | Gamma-crystallin B; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| CHRNA1 protein network | https://string-db.org/network/9606.ENSP00000261007 | Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...] |
| WDR12 protein network | https://string-db.org/network/9606.ENSP00000261015 | Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; WD repeat domain containing |
| ITGAV protein network | https://string-db.org/network/9606.ENSP00000261023 | Integrin alpha-V; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, th [...] |
| SLC40A1 protein network | https://string-db.org/network/9606.ENSP00000261024 | Solute carrier family 40 member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the pr [...] |
| COL8A1 protein network | https://string-db.org/network/9606.ENSP00000261037 | Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the en [...] |
| DIRC2 protein network | https://string-db.org/network/9606.ENSP00000261038 | Disrupted in renal carcinoma protein 2; Electrogenic metabolite transporter; Belongs to the major facilitator superfamily |
| GUCA1C protein network | https://string-db.org/network/9606.ENSP00000261047 | Guanylyl cyclase-activating protein 3; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration [...] |
| CCDC54 protein network | https://string-db.org/network/9606.ENSP00000261058 | Coiled-coil domain containing 54 |
| COX17 protein network | https://string-db.org/network/9606.ENSP00000261070 | Cytochrome c oxidase copper chaperone; Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX (By similarity); Mitochondrial respiratory [...] |
| WBP11 protein network | https://string-db.org/network/9606.ENSP00000261167 | WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity; Protein phosphatase 1 regulatory subunits |
| GUCY2C protein network | https://string-db.org/network/9606.ENSP00000261170 | Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activa [...] |
| EPYC protein network | https://string-db.org/network/9606.ENSP00000261172 | Epiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization; Belongs to the small leucine-rich proteoglycan (SLRP) family. [...] |
| TSPAN11 protein network | https://string-db.org/network/9606.ENSP00000261177 | Tetraspanin-11; Tetraspanin 11; Tetraspanins |
| TRHDE protein network | https://string-db.org/network/9606.ENSP00000261180 | Thyrotropin-releasing hormone-degrading ectoenzyme; Specific inactivation of TRH after its release; Belongs to the peptidase M1 family |
| OSBPL8 protein network | https://string-db.org/network/9606.ENSP00000261183 | Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylser [...] |
| SLC16A7 protein network | https://string-db.org/network/9606.ENSP00000261187 | Monocarboxylate transporter 2; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-ch [...] |
| ASUN protein network | https://string-db.org/network/9606.ENSP00000261191 | Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucl [...] |
| GYS2 protein network | https://string-db.org/network/9606.ENSP00000261195 | Glycogen [starch] synthase, liver; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Glycosyl transferases group 1 domain containing |
| SLCO1B3 protein network | https://string-db.org/network/9606.ENSP00000261196 | Solute carrier organic anion transporter family member 1B3; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), le [...] |
| ABCC9 protein network | https://string-db.org/network/9606.ENSP00000261200 | ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore wh [...] |
| SYT1 protein network | https://string-db.org/network/9606.ENSP00000261205 | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificit [...] |
| HAL protein network | https://string-db.org/network/9606.ENSP00000261208 | Histidine ammonia-lyase |
| CDK17 protein network | https://string-db.org/network/9606.ENSP00000261211 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity); Cyclin dependent kinases |
| TMCC3 protein network | https://string-db.org/network/9606.ENSP00000261226 | Transmembrane and coiled-coil domain containing; Belongs to the TEX28 family |
| IRAK3 protein network | https://string-db.org/network/9606.ENSP00000261233 | Interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or [...] |
| TMEM5 protein network | https://string-db.org/network/9606.ENSP00000261234 | UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase; UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-ac [...] |
| MNAT1 protein network | https://string-db.org/network/9606.ENSP00000261245 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CD [...] |
| TRMT5 protein network | https://string-db.org/network/9606.ENSP00000261249 | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the [...] |
| C12orf4 protein network | https://string-db.org/network/9606.ENSP00000261250 | Protein C12orf4; Plays a role in mast cell degranulation |
| CCND2 protein network | https://string-db.org/network/9606.ENSP00000261254 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...] |
| RAB21 protein network | https://string-db.org/network/9606.ENSP00000261263 | Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell a [...] |
| LYZ protein network | https://string-db.org/network/9606.ENSP00000261267 | Lysozyme C; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents; Lysoz [...] |
| FAM189A1 protein network | https://string-db.org/network/9606.ENSP00000261275 | Protein FAM189A1; Family with sequence similarity 189 member A1; Belongs to the FAM189 family |
| LIPG protein network | https://string-db.org/network/9606.ENSP00000261292 | Endothelial lipase; Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin; Belongs to the AB hyd [...] |
| TGDS protein network | https://string-db.org/network/9606.ENSP00000261296 | dTDP-D-glucose 4,6-dehydratase; Short chain dehydrogenase/reductase superfamily |
| PSMC1 protein network | https://string-db.org/network/9606.ENSP00000261303 | 26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| GALC protein network | https://string-db.org/network/9606.ENSP00000261304 | Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible [...] |
| PPWD1 protein network | https://string-db.org/network/9606.ENSP00000261308 | Peptidylprolyl isomerase domain and WD repeat-containing protein 1; Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerizatio [...] |
| PEBP1 protein network | https://string-db.org/network/9606.ENSP00000261313 | Phosphatidylethanolamine-binding protein 1; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which i [...] |
| C12orf49 protein network | https://string-db.org/network/9606.ENSP00000261318 | UPF0454 protein C12orf49; Chromosome 12 open reading frame 49; Belongs to the UPF0454 family |
| MOCOS protein network | https://string-db.org/network/9606.ENSP00000261326 | Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cof [...] |
| ZNF24 protein network | https://string-db.org/network/9606.ENSP00000261332 | Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinatin [...] |
| PZP protein network | https://string-db.org/network/9606.ENSP00000261336 | Pregnancy zone protein; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific c [...] |
| CLEC2D protein network | https://string-db.org/network/9606.ENSP00000261340 | C-type lectin domain family 2 member D; Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulate [...] |
| LRP6 protein network | https://string-db.org/network/9606.ENSP00000261349 | Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into [...] |
| LMNB1 protein network | https://string-db.org/network/9606.ENSP00000261366 | Lamin-B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope an [...] |
| SNCAIP protein network | https://string-db.org/network/9606.ENSP00000261368 | Synphilin-1; Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation o [...] |
| SNX24 protein network | https://string-db.org/network/9606.ENSP00000261369 | Sorting nexin-24; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family |
| HS3ST2 protein network | https://string-db.org/network/9606.ENSP00000261374 | Heparan sulfate glucosamine 3-O-sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosami [...] |
| LOC81691 protein network | https://string-db.org/network/9606.ENSP00000261377 | Putative RNA exonuclease NEF-sp |
| XYLT1 protein network | https://string-db.org/network/9606.ENSP00000261381 | Xylosyltransferase 1; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the bi [...] |
| DNAH3 protein network | https://string-db.org/network/9606.ENSP00000261383 | Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| GDE1 protein network | https://string-db.org/network/9606.ENSP00000261386 | Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding [...] |
| NUP133 protein network | https://string-db.org/network/9606.ENSP00000261396 | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport; Belongs to the nucleoporin Nup133 family |
| NUAK1 protein network | https://string-db.org/network/9606.ENSP00000261402 | NUAK family SNF1-like kinase 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progres [...] |
| VWF protein network | https://string-db.org/network/9606.ENSP00000261405 | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen [...] |
| LPCAT3 protein network | https://string-db.org/network/9606.ENSP00000261407 | Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-gl [...] |
| HEXB protein network | https://string-db.org/network/9606.ENSP00000261416 | Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues; B [...] |
| UBE2K protein network | https://string-db.org/network/9606.ENSP00000261427 | Ubiquitin-conjugating enzyme E2 K; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubi [...] |
| LIAS protein network | https://string-db.org/network/9606.ENSP00000261434 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent [...] |
| N4BP2 protein network | https://string-db.org/network/9606.ENSP00000261435 | NEDD4-binding protein 2; Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination |
| KLF3 protein network | https://string-db.org/network/9606.ENSP00000261438 | Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family |
| TBC1D1 protein network | https://string-db.org/network/9606.ENSP00000261439 | TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the traffickin [...] |
| RSBN1 protein network | https://string-db.org/network/9606.ENSP00000261441 | Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round [...] |
| CASQ2 protein network | https://string-db.org/network/9606.ENSP00000261448 | Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic re [...] |
| PPP2R5A protein network | https://string-db.org/network/9606.ENSP00000261461 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...] |
| TRAF5 protein network | https://string-db.org/network/9606.ENSP00000261464 | TNF receptor-associated factor 5; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the rec [...] |
| PPP2R3C protein network | https://string-db.org/network/9606.ENSP00000261475 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 express [...] |
| PSMA6 protein network | https://string-db.org/network/9606.ENSP00000261479 | Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| MAN2A1 protein network | https://string-db.org/network/9606.ENSP00000261483 | Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-g [...] |
| EPB41L4A protein network | https://string-db.org/network/9606.ENSP00000261486 | Erythrocyte membrane protein band 4.1 like 4A; FERM domain containing |
| ENOX1 protein network | https://string-db.org/network/9606.ENSP00000261488 | Ecto-NOX disulfide-thiol exchanger 1; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxid [...] |
| USP22 protein network | https://string-db.org/network/9606.ENSP00000261497 | Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histone [...] |
| B9D1 protein network | https://string-db.org/network/9606.ENSP00000261499 | B9 domain-containing protein 1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...] |
| SPECC1 protein network | https://string-db.org/network/9606.ENSP00000261503 | Cytospin-B; Sperm antigen with calponin homology and coiled-coil domains 1 |
| MSMO1 protein network | https://string-db.org/network/9606.ENSP00000261507 | Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family |
| CLCN3 protein network | https://string-db.org/network/9606.ENSP00000261514 | H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, [...] |
| VPS13C protein network | https://string-db.org/network/9606.ENSP00000261517 | Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-med [...] |
| ICE2 protein network | https://string-db.org/network/9606.ENSP00000261520 | Little elongation complex subunit 2; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III; Be [...] |
| RORA protein network | https://string-db.org/network/9606.ENSP00000261523 | Nuclear receptor ROR-alpha; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequenc [...] |
| GPATCH2L protein network | https://string-db.org/network/9606.ENSP00000261530 | G patch domain-containing protein 2-like; G-patch domain containing 2 like |
| SNW1 protein network | https://string-db.org/network/9606.ENSP00000261531 | SNW domain-containing protein 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via associatio [...] |
| POMT2 protein network | https://string-db.org/network/9606.ENSP00000261534 | Protein O-mannosyl-transferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, express [...] |
| MIB1 protein network | https://string-db.org/network/9606.ENSP00000261537 | E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notc [...] |
| TMEM260 protein network | https://string-db.org/network/9606.ENSP00000261556 | Transmembrane protein 260; Belongs to the TMEM260 family |
| AP5M1 protein network | https://string-db.org/network/9606.ENSP00000261558 | AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death; Bel [...] |
| ZNF430 protein network | https://string-db.org/network/9606.ENSP00000261560 | Zinc finger protein 430; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IPO5 protein network | https://string-db.org/network/9606.ENSP00000261574 | Importin-5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...] |
| PALB2 protein network | https://string-db.org/network/9606.ENSP00000261584 | Partner and localizer of BRCA2; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-inv [...] |
| KIAA0556 protein network | https://string-db.org/network/9606.ENSP00000261588 | Protein KIAA0556; May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex |
| DSG2 protein network | https://string-db.org/network/9606.ENSP00000261590 | Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; Desmosomal cadherins |
| NOL4 protein network | https://string-db.org/network/9606.ENSP00000261592 | Nucleolar protein 4 |
| RNF138 protein network | https://string-db.org/network/9606.ENSP00000261593 | E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double- strand break [...] |
| LPIN2 protein network | https://string-db.org/network/9606.ENSP00000261596 | Phosphatidate phosphatase LPIN2; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catal [...] |
| NDC80 protein network | https://string-db.org/network/9606.ENSP00000261597 | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Requir [...] |
| THOC1 protein network | https://string-db.org/network/9606.ENSP00000261600 | THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing a [...] |
| USP14 protein network | https://string-db.org/network/9606.ENSP00000261601 | Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin [...] |
| HERC2 protein network | https://string-db.org/network/9606.ENSP00000261609 | E3 ubiquitin-protein ligase HERC2; E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in respons [...] |
| SLC7A5 protein network | https://string-db.org/network/9606.ENSP00000261622 | Large neutral amino acids transporter small subunit 1; Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, [...] |
| CYBA protein network | https://string-db.org/network/9606.ENSP00000261623 | Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively gene [...] |
| ARL1 protein network | https://string-db.org/network/9606.ENSP00000261636 | ADP-ribosylation factor-like protein 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate ph [...] |
| UTP20 protein network | https://string-db.org/network/9606.ENSP00000261637 | Small subunit processome component 20 homolog; Involved in 18S pre-rRNA processing. Associates with U3 snoRNA; Armadillo-like helical domain containing |
| COX10 protein network | https://string-db.org/network/9606.ENSP00000261643 | Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O; Mitochondrial respiratory chain complex assembly factors |
| TTC19 protein network | https://string-db.org/network/9606.ENSP00000261647 | Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological [...] |
| TNFRSF13B protein network | https://string-db.org/network/9606.ENSP00000261652 | Tumor necrosis factor receptor superfamily member 13B; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent a [...] |
| GPR133 protein network | https://string-db.org/network/9606.ENSP00000261654 | Adhesion G-protein coupled receptor D1; Orphan receptor. Signals via G(s)-alpha family of G- proteins. Has protumorigenic function especially in glioblastoma |
| RIMBP2 protein network | https://string-db.org/network/9606.ENSP00000261655 | RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B; Protein phosphatase 1 regulatory sub [...] |
| BFAR protein network | https://string-db.org/network/9606.ENSP00000261658 | Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors; Ring finger proteins |
| KPNA3 protein network | https://string-db.org/network/9606.ENSP00000261667 | Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| MPP5 protein network | https://string-db.org/network/9606.ENSP00000261681 | MAGUK p55 subfamily member 5; May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabiliz [...] |
| CDK2AP1 protein network | https://string-db.org/network/9606.ENSP00000261692 | Cyclin-dependent kinase 2-associated protein 1; Specific inhibitor of the cell-cycle kinase CDK2 |
| SCARB1 protein network | https://string-db.org/network/9606.ENSP00000261693 | Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Receptor for HDL, mediating sel [...] |
| C14orf166 protein network | https://string-db.org/network/9606.ENSP00000261700 | RNA transcription, translation and transport factor protein; RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and i [...] |
| SLC6A4 protein network | https://string-db.org/network/9606.ENSP00000261707 | Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin mol [...] |
| UTP6 protein network | https://string-db.org/network/9606.ENSP00000261708 | U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA; UTPb subcomplex |
| PSMD11 protein network | https://string-db.org/network/9606.ENSP00000261712 | 26S proteasome non-ATPase regulatory subunit 11; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...] |
| BLMH protein network | https://string-db.org/network/9606.ENSP00000261714 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of [...] |
| TAOK1 protein network | https://string-db.org/network/9606.ENSP00000261716 | Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoske [...] |
| BTBD1 protein network | https://string-db.org/network/9606.ENSP00000261721 | BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tar [...] |
| CUX2 protein network | https://string-db.org/network/9606.ENSP00000261726 | Homeobox protein cut-like 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity); CUT class homeoboxes and pseudogenes |
| LHX5 protein network | https://string-db.org/network/9606.ENSP00000261731 | LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system; LIM class homeoboxes |
| ALDH2 protein network | https://string-db.org/network/9606.ENSP00000261733 | Aldehyde dehydrogenase, mitochondrial; Aldehyde dehydrogenase 2 family member; Belongs to the aldehyde dehydrogenase family |
| ERP29 protein network | https://string-db.org/network/9606.ENSP00000261735 | Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possib [...] |
| ANKRD13A protein network | https://string-db.org/network/9606.ENSP00000261739 | Ankyrin repeat domain-containing protein 13A; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...] |
| NAA25 protein network | https://string-db.org/network/9606.ENSP00000261745 | N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-As [...] |
| ZFAND6 protein network | https://string-db.org/network/9606.ENSP00000261749 | AN1-type zinc finger protein 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'- linked polyubiquitination status of TRAF2 and [...] |
| CHRNB4 protein network | https://string-db.org/network/9606.ENSP00000261751 | Neuronal acetylcholine receptor subunit beta-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...] |
| MESDC2 protein network | https://string-db.org/network/9606.ENSP00000261758 | LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt path [...] |
| CDH1 protein network | https://string-db.org/network/9606.ENSP00000261769 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| AARS protein network | https://string-db.org/network/9606.ENSP00000261772 | Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor [...] |
| VAC14 protein network | https://string-db.org/network/9606.ENSP00000261776 | Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve [...] |
| TANGO6 protein network | https://string-db.org/network/9606.ENSP00000261778 | Transport and golgi organization 6 homolog; Armadillo-like helical domain containing |
| ARG2 protein network | https://string-db.org/network/9606.ENSP00000261783 | Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regu [...] |
| TM9SF1 protein network | https://string-db.org/network/9606.ENSP00000261789 | Transmembrane 9 superfamily member; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family |
| IL17B protein network | https://string-db.org/network/9606.ENSP00000261796 | Interleukin-17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1; Interleukins |
| NDST1 protein network | https://string-db.org/network/9606.ENSP00000261797 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...] |
| PDGFRB protein network | https://string-db.org/network/9606.ENSP00000261799 | Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays [...] |
| FAT2 protein network | https://string-db.org/network/9606.ENSP00000261800 | Protocadherin Fat 2; Plays a role in the migration of epidermal cells. May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity); Cadherin r [...] |
| CYSTM1 protein network | https://string-db.org/network/9606.ENSP00000261811 | Cysteine-rich and transmembrane domain-containing protein 1; Cysteine rich transmembrane module containing 1 |
| PFDN1 protein network | https://string-db.org/network/9606.ENSP00000261813 | Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| ANAPC5 protein network | https://string-db.org/network/9606.ENSP00000261819 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...] |
| CYP46A1 protein network | https://string-db.org/network/9606.ENSP00000261835 | Cholesterol 24-hydroxylase; Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xen [...] |
| GNB5 protein network | https://string-db.org/network/9606.ENSP00000261837 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the s [...] |
| MYO5C protein network | https://string-db.org/network/9606.ENSP00000261839 | Unconventional myosin-Vc; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues; Myosins, class V |
| AP4E1 protein network | https://string-db.org/network/9606.ENSP00000261842 | AP-4 complex subunit epsilon-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. Th [...] |
| MAPK6 protein network | https://string-db.org/network/9606.ENSP00000261845 | Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still uncl [...] |
| SPPL2A protein network | https://string-db.org/network/9606.ENSP00000261854 | Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM [...] |
| GLCE protein network | https://string-db.org/network/9606.ENSP00000261858 | D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N- sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is [...] |
| SPG11 protein network | https://string-db.org/network/9606.ENSP00000261866 | Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport |
| SLC30A4 protein network | https://string-db.org/network/9606.ENSP00000261867 | Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment; Belongs to the cation diffusion facilitator (CDF) transport [...] |
| EIF3J protein network | https://string-db.org/network/9606.ENSP00000261868 | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| PTPLAD1 protein network | https://string-db.org/network/9606.ENSP00000261875 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic proces [...] |
| APH1B protein network | https://string-db.org/network/9606.ENSP00000261879 | Gamma-secretase subunit APH-1B; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and [...] |
| AAGAB protein network | https://string-db.org/network/9606.ENSP00000261880 | Alpha- and gamma-adaptin-binding protein p34; May be involved in endocytic recycling of growth factor receptors such as EGFR |
| TIPIN protein network | https://string-db.org/network/9606.ENSP00000261881 | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replicat [...] |
| CILP protein network | https://string-db.org/network/9606.ENSP00000261883 | Cartilage intermediate layer protein 1; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced prol [...] |
| TRIP4 protein network | https://string-db.org/network/9606.ENSP00000261884 | Activating signal cointegrator 1; Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factor [...] |
| PARP16 protein network | https://string-db.org/network/9606.ENSP00000261888 | Mono [ADP-ribose] polymerase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processe [...] |
| SNX1 protein network | https://string-db.org/network/9606.ENSP00000261889 | Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphospha [...] |
| RAB11A protein network | https://string-db.org/network/9606.ENSP00000261890 | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle be [...] |
| DAPK2 protein network | https://string-db.org/network/9606.ENSP00000261891 | Death-associated protein kinase 2; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regu [...] |
| SLC24A1 protein network | https://string-db.org/network/9606.ENSP00000261892 | Sodium/potassium/calcium exchanger 1; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapi [...] |
| LACTB protein network | https://string-db.org/network/9606.ENSP00000261893 | Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism. Acts by decreasing protein levels of PISD, a mit [...] |
| CCNT1 protein network | https://string-db.org/network/9606.ENSP00000261900 | Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the tr [...] |
| HCN4 protein network | https://string-db.org/network/9606.ENSP00000261917 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for [...] |
| SEMA7A protein network | https://string-db.org/network/9606.ENSP00000261918 | Semaphorin-7A; Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activat [...] |
| LOXL1 protein network | https://string-db.org/network/9606.ENSP00000261921 | Lysyl oxidase homolog 1; Active on elastin and collagen substrates |
| FLT4 protein network | https://string-db.org/network/9606.ENSP00000261937 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the [...] |
| FAF2 protein network | https://string-db.org/network/9606.ENSP00000261942 | FAS-associated factor 2; Plays an important role in endoplasmic reticulum- associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. [...] |
| TUBGCP3 protein network | https://string-db.org/network/9606.ENSP00000261965 | Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome |
| RBM25 protein network | https://string-db.org/network/9606.ENSP00000261973 | RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isofo [...] |
| LTBP2 protein network | https://string-db.org/network/9606.ENSP00000261978 | Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly; Latent transforming growth factor beta [...] |
| VSX2 protein network | https://string-db.org/network/9606.ENSP00000261980 | Visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, p [...] |
| SERPINA10 protein network | https://string-db.org/network/9606.ENSP00000261994 | Protein Z-dependent protease inhibitor; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofa [...] |
| SPAG9 protein network | https://string-db.org/network/9606.ENSP00000262013 | C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...] |
| SGCA protein network | https://string-db.org/network/9606.ENSP00000262018 | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix |
| MARS protein network | https://string-db.org/network/9606.ENSP00000262027 | Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...] |
| ATP5B protein network | https://string-db.org/network/9606.ENSP00000262030 | ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane w [...] |
| RBMS2 protein network | https://string-db.org/network/9606.ENSP00000262031 | RNA-binding motif, single-stranded-interacting protein 2; RNA binding motif single stranded interacting protein 2 |
| IKZF4 protein network | https://string-db.org/network/9606.ENSP00000262032 | Zinc finger protein Eos; DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK [...] |
| PIK3C3 protein network | https://string-db.org/network/9606.ENSP00000262039 | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to [...] |
| MEOX2 protein network | https://string-db.org/network/9606.ENSP00000262041 | Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2 [...] |
| PHF3 protein network | https://string-db.org/network/9606.ENSP00000262043 | PHD finger protein 3 |
| ATF1 protein network | https://string-db.org/network/9606.ENSP00000262053 | Cyclic AMP-dependent transcription factor ATF-1; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Bi [...] |
| MMD protein network | https://string-db.org/network/9606.ENSP00000262065 | Monocyte to macrophage differentiation factor; Involved in the dynamics of lysosomal membranes associated with microglial activation following brain lesion; Progestin and adipoQ receptor family |
| TSPAN13 protein network | https://string-db.org/network/9606.ENSP00000262067 | Tetraspanin-13; Tetraspanin 13; Tetraspanins |
| RAB27B protein network | https://string-db.org/network/9606.ENSP00000262094 | Ras-related protein Rab-27B; May be involved in targeting uroplakins to urothelial apical membranes; RAB, member RAS oncogene GTPases |
| ZDHHC2 protein network | https://string-db.org/network/9606.ENSP00000262096 | Palmitoyltransferase ZDHHC2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95; Zinc fingers DHHC-type |
| MSR1 protein network | https://string-db.org/network/9606.ENSP00000262101 | Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits [...] |
| MTUS1 protein network | https://string-db.org/network/9606.ENSP00000262102 | Microtubule-associated tumor suppressor 1; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces [...] |
| EFCAB1 protein network | https://string-db.org/network/9606.ENSP00000262103 | EF-hand calcium-binding domain-containing protein 1; EF-hand calcium binding domain 1 |
| MCM4 protein network | https://string-db.org/network/9606.ENSP00000262105 | DNA replication licensing factor MCM4; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| ERICH1 protein network | https://string-db.org/network/9606.ENSP00000262109 | Glutamate-rich protein 1; Glutamate rich 1 |
| MYOM2 protein network | https://string-db.org/network/9606.ENSP00000262113 | Myomesin-2; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent; Fibronectin type III domain containing |
| TWSG1 protein network | https://string-db.org/network/9606.ENSP00000262120 | Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs [...] |
| ANKRD12 protein network | https://string-db.org/network/9606.ENSP00000262126 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing |
| CEP76 protein network | https://string-db.org/network/9606.ENSP00000262127 | Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplic [...] |
| RBL2 protein network | https://string-db.org/network/9606.ENSP00000262133 | Retinoblastoma-like protein 2; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of con [...] |
| LPCAT2 protein network | https://string-db.org/network/9606.ENSP00000262134 | Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthes [...] |
| CACNG4 protein network | https://string-db.org/network/9606.ENSP00000262138 | Voltage-dependent calcium channel gamma-4 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane a [...] |
| WIPI1 protein network | https://string-db.org/network/9606.ENSP00000262139 | WD repeat domain phosphoinositide-interacting protein 1; Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upst [...] |
| WDR59 protein network | https://string-db.org/network/9606.ENSP00000262144 | GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC [...] |
| MTFR1 protein network | https://string-db.org/network/9606.ENSP00000262146 | Mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) |
| CDH19 protein network | https://string-db.org/network/9606.ENSP00000262150 | Cadherin-19; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| SMAD7 protein network | https://string-db.org/network/9606.ENSP00000262158 | Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming g [...] |
| SMAD2 protein network | https://string-db.org/network/9606.ENSP00000262160 | Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth fac [...] |
| DNAJB6 protein network | https://string-db.org/network/9606.ENSP00000262177 | DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. S [...] |
| VIPR2 protein network | https://string-db.org/network/9606.ENSP00000262178 | Vasoactive intestinal polypeptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can [...] |
| KCNH2 protein network | https://string-db.org/network/9606.ENSP00000262186 | Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit ass [...] |
| RHEB protein network | https://string-db.org/network/9606.ENSP00000262187 | GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through act [...] |
| SMARCD3 protein network | https://string-db.org/network/9606.ENSP00000262188 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...] |
| KMT2C protein network | https://string-db.org/network/9606.ENSP00000262189 | Histone-lysine N-methyltransferase 2C; Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Cen [...] |
| PSMB1 protein network | https://string-db.org/network/9606.ENSP00000262193 | Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| ADNP2 protein network | https://string-db.org/network/9606.ENSP00000262198 | Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes |
| CRISPLD1 protein network | https://string-db.org/network/9606.ENSP00000262207 | Cysteine rich secretory protein LCCL domain containing 1; Belongs to the CRISP family |
| TRPA1 protein network | https://string-db.org/network/9606.ENSP00000262209 | Transient receptor potential cation channel subfamily A member 1; Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear [...] |
| CSPP1 protein network | https://string-db.org/network/9606.ENSP00000262210 | Centrosome and spindle pole-associated protein 1; May play a role in cell-cycle-dependent microtubule organization |
| TRAM1 protein network | https://string-db.org/network/9606.ENSP00000262213 | Translocating chain-associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; TLC domain containing |
| ARFGEF1 protein network | https://string-db.org/network/9606.ENSP00000262215 | Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Invol [...] |
| ANXA13 protein network | https://string-db.org/network/9606.ENSP00000262219 | Annexin A13; Belongs to the annexin family |
| TMED2 protein network | https://string-db.org/network/9606.ENSP00000262225 | Transmembrane emp24 domain-containing protein 2; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as car [...] |
| RIMS2 protein network | https://string-db.org/network/9606.ENSP00000262231 | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing |
| YY1 protein network | https://string-db.org/network/9606.ENSP00000262238 | Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlappi [...] |
| RCOR1 protein network | https://string-db.org/network/9606.ENSP00000262241 | REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/ [...] |
| MOB3B protein network | https://string-db.org/network/9606.ENSP00000262244 | MOB kinase activator 3B; May regulate the activity of kinases; MOB kinase activators |
| ZNF175 protein network | https://string-db.org/network/9606.ENSP00000262259 | Zinc finger protein 175; Down-regulates the expression of several chemokine receptors. Interferes with HIV-1 replication by suppressing Tat- induced viral LTR promoter activity; Zinc fingers C2H2 [...] |
| CD33 protein network | https://string-db.org/network/9606.ENSP00000262262 | Myeloid cell surface antigen CD33; Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic [...] |
| PIH1D1 protein network | https://string-db.org/network/9606.ENSP00000262265 | PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enh [...] |
| ENSG00000253117 protein network | https://string-db.org/network/9606.ENSP00000262283 | Otoconin-90; It is unlikely that this protein has phospholipase A2 activity |
| SCPEP1 protein network | https://string-db.org/network/9606.ENSP00000262288 | Retinoid-inducible serine carboxypeptidase; May be involved in vascular wall and kidney homeostasis; M14 carboxypeptidases |
| LPO protein network | https://string-db.org/network/9606.ENSP00000262290 | Lactoperoxidase; Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to [...] |
| VMP1 protein network | https://string-db.org/network/9606.ENSP00000262291 | Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization [...] |
| PRR11 protein network | https://string-db.org/network/9606.ENSP00000262293 | Proline-rich protein 11; Plays a critical role in cell cycle progression |
| TRIM37 protein network | https://string-db.org/network/9606.ENSP00000262294 | E3 ubiquitin-protein ligase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediat [...] |
| PKMYT1 protein network | https://string-db.org/network/9606.ENSP00000262300 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specific [...] |
| LMF1 protein network | https://string-db.org/network/9606.ENSP00000262301 | Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secr [...] |
| NUBP2 protein network | https://string-db.org/network/9606.ENSP00000262302 | Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP [...] |
| PKD1 protein network | https://string-db.org/network/9606.ENSP00000262304 | Polycystin-1; Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity). Acts as a regulator of cilium length, together wi [...] |
| RAB11FIP3 protein network | https://string-db.org/network/9606.ENSP00000262305 | Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'addre [...] |
| TCEB2 protein network | https://string-db.org/network/9606.ENSP00000262306 | Elongin-B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...] |
| CHTF18 protein network | https://string-db.org/network/9606.ENSP00000262315 | Chromosome transmission fidelity protein 18 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear [...] |
| RHBDF1 protein network | https://string-db.org/network/9606.ENSP00000262316 | Inactive rhomboid protein 1; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activ [...] |
| TELO2 protein network | https://string-db.org/network/9606.ENSP00000262319 | Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kin [...] |
| AXIN1 protein network | https://string-db.org/network/9606.ENSP00000262320 | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral pat [...] |
| RPE65 protein network | https://string-db.org/network/9606.ENSP00000262340 | Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomeriza [...] |
| IL12RB2 protein network | https://string-db.org/network/9606.ENSP00000262345 | Interleukin-12 receptor subunit beta-2; Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as N [...] |
| SLC1A1 protein network | https://string-db.org/network/9606.ENSP00000262352 | Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cyst [...] |
| FAM86B2 protein network | https://string-db.org/network/9606.ENSP00000262365 | Putative protein N-methyltransferase FAM86B2; Seven-beta-strand methyltransferase motif containing |
| GLIS2 protein network | https://string-db.org/network/9606.ENSP00000262366 | Zinc finger protein GLIS2; Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway (B [...] |
| CREBBP protein network | https://string-db.org/network/9606.ENSP00000262367 | CREB-binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated C [...] |
| MGRN1 protein network | https://string-db.org/network/9606.ENSP00000262370 | E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in th [...] |
| ALG1 protein network | https://string-db.org/network/9606.ENSP00000262374 | Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyropho [...] |
| DNAJA3 protein network | https://string-db.org/network/9606.ENSP00000262375 | DnaJ homolog subfamily A member 3, mitochondrial; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria [...] |
| N4BP1 protein network | https://string-db.org/network/9606.ENSP00000262384 | NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquiti [...] |
| WSB1 protein network | https://string-db.org/network/9606.ENSP00000262394 | WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitina [...] |
| TRAF4 protein network | https://string-db.org/network/9606.ENSP00000262395 | TNF receptor-associated factor 4; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the [...] |
| RGS9 protein network | https://string-db.org/network/9606.ENSP00000262406 | Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G( [...] |
| ITGA2B protein network | https://string-db.org/network/9606.ENSP00000262407 | Integrin alpha-IIb; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array [...] |
| DHX8 protein network | https://string-db.org/network/9606.ENSP00000262415 | ATP-dependent RNA helicase DHX8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subf [...] |
| SLC4A1 protein network | https://string-db.org/network/9606.ENSP00000262418 | Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprot [...] |
| KANSL1 protein network | https://string-db.org/network/9606.ENSP00000262419 | KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...] |
| CRISPLD2 protein network | https://string-db.org/network/9606.ENSP00000262424 | Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly; Belongs to the CRISP family |
| FOXF1 protein network | https://string-db.org/network/9606.ENSP00000262426 | Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes; Forkhead boxes |
| COTL1 protein network | https://string-db.org/network/9606.ENSP00000262428 | Coactosin-like protein; Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and a [...] |
| MLYCD protein network | https://string-db.org/network/9606.ENSP00000262430 | Malonyl-CoA decarboxylase, mitochondrial; Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-ma [...] |
| METTL2B protein network | https://string-db.org/network/9606.ENSP00000262432 | Methyltransferase-like protein 2B; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs |
| SMURF2 protein network | https://string-db.org/network/9606.ENSP00000262435 | E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...] |
| GLP2R protein network | https://string-db.org/network/9606.ENSP00000262441 | Glucagon-like peptide 2 receptor; This is a receptor for glucagon-like peptide 2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase |
| DNAH9 protein network | https://string-db.org/network/9606.ENSP00000262442 | Dynein heavy chain 9, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| CHD5 protein network | https://string-db.org/network/9606.ENSP00000262450 | Chromodomain-helicase-DNA-binding protein 5; Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys- [...] |
| ERP44 protein network | https://string-db.org/network/9606.ENSP00000262455 | Endoplasmic reticulum resident protein 44; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. In [...] |
| INVS protein network | https://string-db.org/network/9606.ENSP00000262457 | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt path [...] |
| GINS1 protein network | https://string-db.org/network/9606.ENSP00000262460 | DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind pref [...] |
| SLC12A2 protein network | https://string-db.org/network/9606.ENSP00000262461 | Solute carrier family 12 member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume; Belong [...] |
| SLC27A6 protein network | https://string-db.org/network/9606.ENSP00000262462 | Long-chain fatty acid transport protein 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transpo [...] |
| RNF167 protein network | https://string-db.org/network/9606.ENSP00000262482 | E3 ubiquitin-protein ligase RNF167; May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1 [...] |
| PITPNM3 protein network | https://string-db.org/network/9606.ENSP00000262483 | Membrane-associated phosphatidylinositol transfer protein 3; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro) (By similarity). Binds calcium ion [...] |
| ISM1 protein network | https://string-db.org/network/9606.ENSP00000262487 | Isthmin-1; Acts as an angiogenesis inhibitor; Belongs to the isthmin family |
| GNAO1 protein network | https://string-db.org/network/9606.ENSP00000262494 | Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G [...] |
| CFAP20 protein network | https://string-db.org/network/9606.ENSP00000262498 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and mor [...] |
| CSNK2A2 protein network | https://string-db.org/network/9606.ENSP00000262506 | Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C- [...] |
| COQ9 protein network | https://string-db.org/network/9606.ENSP00000262507 | Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for a [...] |
| NLRC5 protein network | https://string-db.org/network/9606.ENSP00000262510 | Protein NLRC5; Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of in [...] |
| SRCAP protein network | https://string-db.org/network/9606.ENSP00000262518 | Helicase SRCAP; Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of sel [...] |
| SETD1A protein network | https://string-db.org/network/9606.ENSP00000262519 | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if [...] |
| ZNF629 protein network | https://string-db.org/network/9606.ENSP00000262525 | Zinc finger protein 629; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PCSK2 protein network | https://string-db.org/network/9606.ENSP00000262545 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon f [...] |
| DZANK1 protein network | https://string-db.org/network/9606.ENSP00000262547 | Double zinc ribbon and ankyrin repeat domains 1 |
| OGN protein network | https://string-db.org/network/9606.ENSP00000262551 | Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2; Small leucine rich repeat proteoglycans |
| SPTLC1 protein network | https://string-db.org/network/9606.ENSP00000262554 | Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase ( [...] |
| CHCHD3 protein network | https://string-db.org/network/9606.ENSP00000262570 | MICOS complex subunit MIC19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| ZC3H3 protein network | https://string-db.org/network/9606.ENSP00000262577 | Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus. Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA [...] |
| RPL8 protein network | https://string-db.org/network/9606.ENSP00000262584 | 60S ribosomal protein L8; Component of the large ribosomal subunit |
| DENND3 protein network | https://string-db.org/network/9606.ENSP00000262585 | DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound for [...] |
| DOK5 protein network | https://string-db.org/network/9606.ENSP00000262593 | Docking protein 5; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in [...] |
| SLC9A3R1 protein network | https://string-db.org/network/9606.ENSP00000262613 | Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the acti [...] |
| CHST8 protein network | https://string-db.org/network/9606.ENSP00000262622 | Carbohydrate sulfotransferase 8; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Required for biosynthesi [...] |
| ATP4A protein network | https://string-db.org/network/9606.ENSP00000262623 | Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the sto [...] |
| HPN protein network | https://string-db.org/network/9606.ENSP00000262626 | Serine protease hepsin; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell gro [...] |
| TYROBP protein network | https://string-db.org/network/9606.ENSP00000262629 | TYRO protein tyrosine kinase-binding protein; Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Invo [...] |
| RBM42 protein network | https://string-db.org/network/9606.ENSP00000262633 | RNA-binding protein 42; Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA; RNA binding motif containing |
| VAMP7 protein network | https://string-db.org/network/9606.ENSP00000262640 | Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. [...] |
| CCNE1 protein network | https://string-db.org/network/9606.ENSP00000262643 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily |
| IMPAD1 protein network | https://string-db.org/network/9606.ENSP00000262644 | Inositol monophosphatase 3; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi su [...] |
| RAB2A protein network | https://string-db.org/network/9606.ENSP00000262646 | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases |
| KAL1 protein network | https://string-db.org/network/9606.ENSP00000262648 | Anosmin-1; Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Che [...] |
| CBFA2T2 protein network | https://string-db.org/network/9606.ENSP00000262653 | Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...] |
| CCM2L protein network | https://string-db.org/network/9606.ENSP00000262659 | Cerebral cavernous malformations 2 protein-like; CCM2 like scaffolding protein |
| CDKN2C protein network | https://string-db.org/network/9606.ENSP00000262662 | Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; [...] |
| ACIN1 protein network | https://string-db.org/network/9606.ENSP00000262710 | Apoptotic chromatin condensation inducer in the nucleus; Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a [...] |
| AJUBA protein network | https://string-db.org/network/9606.ENSP00000262713 | LIM domain-containing protein ajuba; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate d [...] |
| TEP1 protein network | https://string-db.org/network/9606.ENSP00000262715 | Telomerase protein component 1; Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini. Also component of the ribonucleoprotein vaults p [...] |
| CDH20 protein network | https://string-db.org/network/9606.ENSP00000262717 | Cadherin-20; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| PHLPP1 protein network | https://string-db.org/network/9606.ENSP00000262719 | PH domain leucine-rich repeat-containing protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobi [...] |
| EFCAB6 protein network | https://string-db.org/network/9606.ENSP00000262726 | EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogati [...] |
| CELSR1 protein network | https://string-db.org/network/9606.ENSP00000262738 | Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation; Adhesion G protein-coupled receptors, subfamily C |
| PIK3R3 protein network | https://string-db.org/network/9606.ENSP00000262741 | Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin sti [...] |
| PRDX1 protein network | https://string-db.org/network/9606.ENSP00000262746 | Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...] |
| RPS6KA6 protein network | https://string-db.org/network/9606.ENSP00000262752 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent c [...] |
| POF1B protein network | https://string-db.org/network/9606.ENSP00000262753 | Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development |
| PGS1 protein network | https://string-db.org/network/9606.ENSP00000262764 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the [...] |
| QRICH2 protein network | https://string-db.org/network/9606.ENSP00000262765 | Glutamine-rich protein 2; Glutamine rich 2 |
| TIMP2 protein network | https://string-db.org/network/9606.ENSP00000262768 | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2 [...] |
| LGALS3BP protein network | https://string-db.org/network/9606.ENSP00000262776 | Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells; BTB domain containing |
| MOV10L1 protein network | https://string-db.org/network/9606.ENSP00000262794 | RNA helicase Mov10l1; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts v [...] |
| ELL protein network | https://string-db.org/network/9606.ENSP00000262809 | RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by [...] |
| MAST3 protein network | https://string-db.org/network/9606.ENSP00000262811 | Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family |
| COPE protein network | https://string-db.org/network/9606.ENSP00000262812 | Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosy [...] |
| MAU2 protein network | https://string-db.org/network/9606.ENSP00000262815 | MAU2 chromatid cohesion factor homolog; Required for association of the cohesin complex with chromatin during interphase. Plays a role in sister chromatid cohesion and normal progression through [...] |
| TRPC5 protein network | https://string-db.org/network/9606.ENSP00000262839 | Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...] |
| MID2 protein network | https://string-db.org/network/9606.ENSP00000262843 | Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization; Belongs to the TRIM/RBCC family |
| AMMECR1 protein network | https://string-db.org/network/9606.ENSP00000262844 | AMME syndrome candidate gene 1 protein; Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 |
| PRKX protein network | https://string-db.org/network/9606.ENSP00000262848 | cAMP-dependent protein kinase catalytic subunit PRKX; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that m [...] |
| RRAGB protein network | https://string-db.org/network/9606.ENSP00000262850 | Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling casc [...] |
| BPI protein network | https://string-db.org/network/9606.ENSP00000262865 | Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very [...] |
| SLA2 protein network | https://string-db.org/network/9606.ENSP00000262866 | Src-like-adapter 2; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May ac [...] |
| MYH7B protein network | https://string-db.org/network/9606.ENSP00000262873 | Myosin-7B; Involved in muscle contraction; Myosin heavy chains |
| SAMHD1 protein network | https://string-db.org/network/9606.ENSP00000262878 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Host restriction nuclease involved in defense response to virus. Has dNTPase activity and reduces cellular dNTP levels to levels too low f [...] |
| RALGAPB protein network | https://string-db.org/network/9606.ENSP00000262879 | Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB; A [...] |
| XRCC1 protein network | https://string-db.org/network/9606.ENSP00000262887 | DNA repair protein XRCC1; Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose l [...] |
| KCNN4 protein network | https://string-db.org/network/9606.ENSP00000262888 | Intermediate conductance calcium-activated potassium channel protein 4; Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membran [...] |
| MARK4 protein network | https://string-db.org/network/9606.ENSP00000262891 | MAP/microtubule affinity-regulating kinase 4; Serine/threonine-protein kinase. Phosphorylates the microtubule-associated protein MAPT. Also phosphorylates the microtubule-associated proteins MAP2 [...] |
| ZNF225 protein network | https://string-db.org/network/9606.ENSP00000262894 | Zinc finger protein 225; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GRIK5 protein network | https://string-db.org/network/9606.ENSP00000262895 | Glutamate receptor ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Gl [...] |
| HACE1 protein network | https://string-db.org/network/9606.ENSP00000262903 | E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cy [...] |
| E2F3 protein network | https://string-db.org/network/9606.ENSP00000262904 | Transcription factor E2F3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of ge [...] |
| ST3GAL3 protein network | https://string-db.org/network/9606.ENSP00000262915 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Sialyltransferases |
| KCNQ4 protein network | https://string-db.org/network/9606.ENSP00000262916 | Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of [...] |
| ATRN protein network | https://string-db.org/network/9606.ENSP00000262919 | Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that [...] |
| CNPY4 protein network | https://string-db.org/network/9606.ENSP00000262932 | Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4 |
| RASA4 protein network | https://string-db.org/network/9606.ENSP00000262940 | Ras GTPase-activating protein 4; Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an a [...] |
| ARPC1A protein network | https://string-db.org/network/9606.ENSP00000262942 | Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleat [...] |
| C19orf10 protein network | https://string-db.org/network/9606.ENSP00000262947 | Myeloid-derived growth factor; Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair afte [...] |
| MAP2K2 protein network | https://string-db.org/network/9606.ENSP00000262948 | Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activ [...] |
| GNA15 protein network | https://string-db.org/network/9606.ENSP00000262958 | Guanine nucleotide-binding protein subunit alpha-15; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G prote [...] |
| DPP9 protein network | https://string-db.org/network/9606.ENSP00000262960 | Dipeptidyl peptidase 9; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2; Belongs to the peptidase S9B family. DPPIV subfamily |
| ZFR2 protein network | https://string-db.org/network/9606.ENSP00000262961 | Zinc finger RNA binding protein 2 |
| CCDC94 protein network | https://string-db.org/network/9606.ENSP00000262962 | Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form t [...] |
| TCF3 protein network | https://string-db.org/network/9606.ENSP00000262965 | Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) prot [...] |
| PIAS4 protein network | https://string-db.org/network/9606.ENSP00000262971 | E3 SUMO-protein ligase PIAS4; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...] |
| CSE1L protein network | https://string-db.org/network/9606.ENSP00000262982 | Exportin-2; Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In t [...] |
| ZNF330 protein network | https://string-db.org/network/9606.ENSP00000262990 | Zinc finger protein 330; Zinc fingers C2H2-type |
| GAB1 protein network | https://string-db.org/network/9606.ENSP00000262995 | GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably in [...] |
| UCP1 protein network | https://string-db.org/network/9606.ENSP00000262999 | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non- [...] |
| MAPK3 protein network | https://string-db.org/network/9606.ENSP00000263025 | Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which pla [...] |
| EEF2K protein network | https://string-db.org/network/9606.ENSP00000263026 | Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases incl [...] |
| DHTKD1 protein network | https://string-db.org/network/9606.ENSP00000263035 | Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It [...] |
| PHYH protein network | https://string-db.org/network/9606.ENSP00000263038 | Phytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA |
| SORCS1 protein network | https://string-db.org/network/9606.ENSP00000263054 | Sortilin related VPS10 domain containing receptor 1; Belongs to the VPS10-related sortilin family. SORCS subfamily |
| MAP3K8 protein network | https://string-db.org/network/9606.ENSP00000263056 | Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for producti [...] |
| EPC1 protein network | https://string-db.org/network/9606.ENSP00000263062 | Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleos [...] |
| MTPAP protein network | https://string-db.org/network/9606.ENSP00000263063 | Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). [...] |
| SCARF1 protein network | https://string-db.org/network/9606.ENSP00000263071 | Scavenger receptor class F member 1; Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion pro [...] |
| SMG6 protein network | https://string-db.org/network/9606.ENSP00000263073 | Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regu [...] |
| ASPA protein network | https://string-db.org/network/9606.ENSP00000263080 | Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant [...] |
| DPH1 protein network | https://string-db.org/network/9606.ENSP00000263083 | 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation el [...] |
| ITGAE protein network | https://string-db.org/network/9606.ENSP00000263087 | Integrin alpha-E; Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers |
| PLD2 protein network | https://string-db.org/network/9606.ENSP00000263088 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Phospholipases |
| METTL16 protein network | https://string-db.org/network/9606.ENSP00000263092 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L- methionine homeos [...] |
| SLC27A5 protein network | https://string-db.org/network/9606.ENSP00000263093 | Bile acyl-CoA synthetase; Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine befor [...] |
| ABCA7 protein network | https://string-db.org/network/9606.ENSP00000263094 | ATP-binding cassette sub-family A member 7; Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. [...] |
| ZNF264 protein network | https://string-db.org/network/9606.ENSP00000263095 | Zinc finger protein 264; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CNN2 protein network | https://string-db.org/network/9606.ENSP00000263097 | Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...] |
| A1BG protein network | https://string-db.org/network/9606.ENSP00000263100 | Alpha-1B-glycoprotein; Immunoglobulin like domain containing |
| CCDC6 protein network | https://string-db.org/network/9606.ENSP00000263102 | Coiled-coil domain containing 6 |
| RAB36 protein network | https://string-db.org/network/9606.ENSP00000263116 | Ras-related protein Rab-36; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family |
| SMARCB1 protein network | https://string-db.org/network/9606.ENSP00000263121 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays [...] |
| PRKCQ protein network | https://string-db.org/network/9606.ENSP00000263125 | Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non- redundant functions in T-cell receptor (TCR) [...] |
| SLC17A6 protein network | https://string-db.org/network/9606.ENSP00000263160 | Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...] |
| CAPZA1 protein network | https://string-db.org/network/9606.ENSP00000263168 | F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...] |
| PALMD protein network | https://string-db.org/network/9606.ENSP00000263174 | Palmdelphin |
| LPPR5 protein network | https://string-db.org/network/9606.ENSP00000263177 | Phospholipid phosphatase-related protein type 5; Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory- mediated axonal retracti [...] |
| KIF18A protein network | https://string-db.org/network/9606.ENSP00000263181 | Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement du [...] |
| BBOX1 protein network | https://string-db.org/network/9606.ENSP00000263182 | Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family |
| MSH4 protein network | https://string-db.org/network/9606.ENSP00000263187 | MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis; Belongs to the DNA mismatch repair Mu [...] |
| DGCR2 protein network | https://string-db.org/network/9606.ENSP00000263196 | Integral membrane protein DGCR2/IDD; Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration; C-type lec [...] |
| UFD1L protein network | https://string-db.org/network/9606.ENSP00000263202 | Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary compl [...] |
| MED15 protein network | https://string-db.org/network/9606.ENSP00000263205 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| ARVCF protein network | https://string-db.org/network/9606.ENSP00000263207 | Armadillo repeat protein deleted in velo-cardio-facial syndrome; Involved in protein-protein interactions at adherens junctions; Belongs to the beta-catenin family |
| HIRA protein network | https://string-db.org/network/9606.ENSP00000263208 | Protein HIRA; Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for t [...] |
| DGCR8 protein network | https://string-db.org/network/9606.ENSP00000263209 | Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Com [...] |
| PPM1F protein network | https://string-db.org/network/9606.ENSP00000263212 | Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM- kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kin [...] |
| UBE2R2 protein network | https://string-db.org/network/9606.ENSP00000263228 | Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyub [...] |
| SYP protein network | https://string-db.org/network/9606.ENSP00000263233 | Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and [...] |
| ACTR3 protein network | https://string-db.org/network/9606.ENSP00000263238 | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting fact [...] |
| DDX18 protein network | https://string-db.org/network/9606.ENSP00000263239 | ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily |
| ARFGAP3 protein network | https://string-db.org/network/9606.ENSP00000263245 | ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from G [...] |
| PACSIN2 protein network | https://string-db.org/network/9606.ENSP00000263246 | Protein kinase C and casein kinase substrate in neurons protein 2; Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially bin [...] |
| EP300 protein network | https://string-db.org/network/9606.ENSP00000263253 | Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation [...] |
| DESI1 protein network | https://string-db.org/network/9606.ENSP00000263256 | Desumoylating isopeptidase 1; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46 (By similarit [...] |
| NOVA2 protein network | https://string-db.org/network/9606.ENSP00000263257 | RNA-binding protein Nova-2; May regulate RNA splicing or metabolism in a specific subset of developing neurons (By similarity). Binds single strand RNA |
| PLEKHA4 protein network | https://string-db.org/network/9606.ENSP00000263265 | Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides; Pleckstrin homology domain containi [...] |
| FAM83E protein network | https://string-db.org/network/9606.ENSP00000263266 | Protein FAM83E; May play a role in MAPK signaling |
| GRIN2D protein network | https://string-db.org/network/9606.ENSP00000263269 | Glutamate receptor ionotropic, NMDA 2D; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...] |
| AP2S1 protein network | https://string-db.org/network/9606.ENSP00000263270 | AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathway [...] |
| LIG1 protein network | https://string-db.org/network/9606.ENSP00000263274 | DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family |
| EHD2 protein network | https://string-db.org/network/9606.ENSP00000263277 | EH domain-containing protein 2; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking betwee [...] |
| HSD17B14 protein network | https://string-db.org/network/9606.ENSP00000263278 | 17-beta-hydroxysteroid dehydrogenase 14; Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestra [...] |
| LY9 protein network | https://string-db.org/network/9606.ENSP00000263285 | T-lymphocyte surface antigen Ly-9; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are [...] |
| P2RX3 protein network | https://string-db.org/network/9606.ENSP00000263314 | P2X purinoceptor 3; Receptor for ATP that acts as a ligand-gated ion channel; Purinergic receptors P2X |
| NOX4 protein network | https://string-db.org/network/9606.ENSP00000263317 | NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases in [...] |
| TYR protein network | https://string-db.org/network/9606.ENSP00000263321 | Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the [...] |
| IL37 protein network | https://string-db.org/network/9606.ENSP00000263326 | Interleukin-37; Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine p [...] |
| PAX8 protein network | https://string-db.org/network/9606.ENSP00000263334 | Paired box protein Pax-8; Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such [...] |
| IL1A protein network | https://string-db.org/network/9606.ENSP00000263339 | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activit [...] |
| IL1B protein network | https://string-db.org/network/9606.ENSP00000263341 | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and [...] |
| TCF25 protein network | https://string-db.org/network/9606.ENSP00000263346 | Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart develo [...] |
| NAPA protein network | https://string-db.org/network/9606.ENSP00000263354 | Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus (Probable). Together with GNA12 promotes CDH5 localization to plas [...] |
| EED protein network | https://string-db.org/network/9606.ENSP00000263360 | Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affe [...] |
| BLVRB protein network | https://string-db.org/network/9606.ENSP00000263368 | Flavin reductase (NADPH); Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ [...] |
| MIA protein network | https://string-db.org/network/9606.ENSP00000263369 | Melanoma-derived growth regulatory protein; Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas; Belongs to the MIA/OTOR family |
| ITPKC protein network | https://string-db.org/network/9606.ENSP00000263370 | Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate; Belongs to the inositol phosphokinase (IPK) family |
| KCNK6 protein network | https://string-db.org/network/9606.ENSP00000263372 | Potassium channel subfamily K member 6; Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions; Belongs to the two pore domai [...] |
| SPTBN4 protein network | https://string-db.org/network/9606.ENSP00000263373 | Spectrin beta chain, non-erythrocytic 4; Pleckstrin homology domain containing |
| BRD4 protein network | https://string-db.org/network/9606.ENSP00000263377 | Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transc [...] |
| IL27RA protein network | https://string-db.org/network/9606.ENSP00000263379 | Interleukin-27 receptor subunit alpha; Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in [...] |
| WIZ protein network | https://string-db.org/network/9606.ENSP00000263381 | Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization (By similarity); Zinc fi [...] |
| ASF1B protein network | https://string-db.org/network/9606.ENSP00000263382 | Histone chaperone ASF1B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly fact [...] |
| ILVBL protein network | https://string-db.org/network/9606.ENSP00000263383 | Acetolactate synthase-like protein; ilvB acetolactate synthase like |
| FAM32A protein network | https://string-db.org/network/9606.ENSP00000263384 | Protein FAM32A; Isoform 1, but not isoform 2 or isoform 3, may induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli; Spliceosomal C complex |
| NOTCH3 protein network | https://string-db.org/network/9606.ENSP00000263388 | Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...] |
| MED26 protein network | https://string-db.org/network/9606.ENSP00000263390 | Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| COMMD9 protein network | https://string-db.org/network/9606.ENSP00000263401 | COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cel [...] |
| C9 protein network | https://string-db.org/network/9606.ENSP00000263408 | Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. [...] |
| LIFR protein network | https://string-db.org/network/9606.ENSP00000263409 | Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to recepto [...] |
| C6 protein network | https://string-db.org/network/9606.ENSP00000263413 | Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; [...] |
| PRKCG protein network | https://string-db.org/network/9606.ENSP00000263431 | Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such a [...] |
| PPP1R12C protein network | https://string-db.org/network/9606.ENSP00000263433 | Protein phosphatase 1 regulatory subunit 12C; Regulates myosin phosphatase activity; Ankyrin repeat domain containing |
| WDR11 protein network | https://string-db.org/network/9606.ENSP00000263461 | WD repeat-containing protein 11; WD repeat domain containing |
| BIRC3 protein network | https://string-db.org/network/9606.ENSP00000263464 | Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase sig [...] |
| KIAA1377 protein network | https://string-db.org/network/9606.ENSP00000263468 | Centrosomal protein of 126 kDa; Participates in cytokinesis. Necessary for microtubules and mitotic spindle organization. Involved in primary cilium formation |
| SLC10A3 protein network | https://string-db.org/network/9606.ENSP00000263512 | P3 protein; The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions; Solute carriers |
| ATP2B3 protein network | https://string-db.org/network/9606.ENSP00000263519 | Plasma membrane calcium-transporting ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting |
| PARP12 protein network | https://string-db.org/network/9606.ENSP00000263549 | poly(ADP-ribose) polymerase family member 12 |
| P4HA1 protein network | https://string-db.org/network/9606.ENSP00000263556 | Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family |
| PALD1 protein network | https://string-db.org/network/9606.ENSP00000263563 | Paladin; Phosphatase domain containing, paladin 1 |
| APLP2 protein network | https://string-db.org/network/9606.ENSP00000263574 | Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signalin [...] |
| DDX25 protein network | https://string-db.org/network/9606.ENSP00000263576 | ATP-dependent RNA helicase DDX25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity); DEAD-box helicases |
| FOXRED1 protein network | https://string-db.org/network/9606.ENSP00000263578 | FAD-dependent oxidoreductase domain-containing protein 1; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of [...] |
| DCPS protein network | https://string-db.org/network/9606.ENSP00000263579 | m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hyd [...] |
| SIAE protein network | https://string-db.org/network/9606.ENSP00000263593 | Sialate O-acetylesterase; Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid |
| LCN1 protein network | https://string-db.org/network/9606.ENSP00000263598 | Lipocalin-1; Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical struct [...] |
| BARHL1 protein network | https://string-db.org/network/9606.ENSP00000263610 | BarH-like 1 homeobox protein; NKL subclass homeoboxes and pseudogenes |
| ARID3A protein network | https://string-db.org/network/9606.ENSP00000263620 | AT-rich interactive domain-containing protein 3A; Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation; AT-ric [...] |
| MTIF2 protein network | https://string-db.org/network/9606.ENSP00000263629 | Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes [...] |
| ENSG00000115239 protein network | https://string-db.org/network/9606.ENSP00000263634 | GPR75-ASB3 readthrough; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subs [...] |
| TANC1 protein network | https://string-db.org/network/9606.ENSP00000263635 | Protein TANC1; May be a scaffold component in the postsynaptic density; Ankyrin repeat domain containing |
| LY75 protein network | https://string-db.org/network/9606.ENSP00000263636 | Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen- processing compartment (By similarity). Causes reduced prol [...] |
| ACVR1 protein network | https://string-db.org/network/9606.ENSP00000263640 | Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate [...] |
| IFIH1 protein network | https://string-db.org/network/9606.ENSP00000263642 | Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and i [...] |
| CD81 protein network | https://string-db.org/network/9606.ENSP00000263645 | CD81 antigen; May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as t [...] |
| OSBPL5 protein network | https://string-db.org/network/9606.ENSP00000263650 | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylser [...] |
| CNRIP1 protein network | https://string-db.org/network/9606.ENSP00000263655 | CB1 cannabinoid receptor-interacting protein 1; Isoform 1 suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. Isoform 2 does not have this effect |
| PNO1 protein network | https://string-db.org/network/9606.ENSP00000263657 | RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA |
| TAF1B protein network | https://string-db.org/network/9606.ENSP00000263663 | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple st [...] |
| CNTN3 protein network | https://string-db.org/network/9606.ENSP00000263665 | Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfami [...] |
| PDZRN3 protein network | https://string-db.org/network/9606.ENSP00000263666 | E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its en [...] |
| CHRDL2 protein network | https://string-db.org/network/9606.ENSP00000263671 | Chordin-related protein 2 variant III; Chordin like 2 |
| SPCS2 protein network | https://string-db.org/network/9606.ENSP00000263672 | Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endopla [...] |
| ARHGEF17 protein network | https://string-db.org/network/9606.ENSP00000263674 | Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases |
| POLD3 protein network | https://string-db.org/network/9606.ENSP00000263681 | DNA polymerase delta subunit 3; As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replic [...] |
| SELP protein network | https://string-db.org/network/9606.ENSP00000263686 | P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocy [...] |
| SNRNP40 protein network | https://string-db.org/network/9606.ENSP00000263694 | U5 small nuclear ribonucleoprotein 40 kDa protein; Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that cataly [...] |
| DNAJC8 protein network | https://string-db.org/network/9606.ENSP00000263697 | DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells; DNAJ heat shock proteins |
| MECR protein network | https://string-db.org/network/9606.ENSP00000263702 | Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fa [...] |
| TFCP2L1 protein network | https://string-db.org/network/9606.ENSP00000263707 | Transcription factor CP2-like protein 1; Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With KLF2, acts as the major effector [...] |
| PTPN4 protein network | https://string-db.org/network/9606.ENSP00000263708 | Tyrosine-protein phosphatase non-receptor type 4; May act at junctions between the membrane and the cytoskeleton; Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily |
| CLASP1 protein network | https://string-db.org/network/9606.ENSP00000263710 | CLIP-associating protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating fr [...] |
| EPB41L5 protein network | https://string-db.org/network/9606.ENSP00000263713 | Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells; FERM domain containing |
| LHX4 protein network | https://string-db.org/network/9606.ENSP00000263726 | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes |
| FAM20B protein network | https://string-db.org/network/9606.ENSP00000263733 | Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG cha [...] |
| EPAS1 protein network | https://string-db.org/network/9606.ENSP00000263734 | Endothelial PAS domain-containing protein 1; Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response elemen [...] |
| EPCAM protein network | https://string-db.org/network/9606.ENSP00000263735 | Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epitheliu [...] |
| SRBD1 protein network | https://string-db.org/network/9606.ENSP00000263736 | S1 RNA-binding domain-containing protein 1; S1 RNA binding domain 1 |
| SGOL1 protein network | https://string-db.org/network/9606.ENSP00000263753 | Shugoshin 1; Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex disso [...] |
| KAT2B protein network | https://string-db.org/network/9606.ENSP00000263754 | Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 an [...] |
| FNBP4 protein network | https://string-db.org/network/9606.ENSP00000263773 | Formin binding protein 4 |
| NDUFS3 protein network | https://string-db.org/network/9606.ENSP00000263774 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...] |
| ACCS protein network | https://string-db.org/network/9606.ENSP00000263776 | 1-aminocyclopropane-1-carboxylate synthase-like protein 1; Does not catalyze the synthesis of 1-aminocyclopropane- 1-carboxylate but is capable of catalyzing the deamination of L- vinylglycine |
| CHMP2B protein network | https://string-db.org/network/9606.ENSP00000263780 | Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| EIF2AK4 protein network | https://string-db.org/network/9606.ENSP00000263791 | eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response t [...] |
| WDR76 protein network | https://string-db.org/network/9606.ENSP00000263795 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC; WD repeat domain containing |
| TYRO3 protein network | https://string-db.org/network/9606.ENSP00000263798 | Tyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Re [...] |
| LTK protein network | https://string-db.org/network/9606.ENSP00000263800 | Leukocyte tyrosine kinase receptor; Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular [...] |
| ZNF106 protein network | https://string-db.org/network/9606.ENSP00000263805 | Zinc finger protein 106; WD repeat domain containing |
| LRP2 protein network | https://string-db.org/network/9606.ENSP00000263816 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Me [...] |
| ABCB11 protein network | https://string-db.org/network/9606.ENSP00000263817 | Bile salt export pump; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exp [...] |
| AKT3 protein network | https://string-db.org/network/9606.ENSP00000263826 | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includ [...] |
| OSBP protein network | https://string-db.org/network/9606.ENSP00000263847 | Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphat [...] |
| ZC2HC1A protein network | https://string-db.org/network/9606.ENSP00000263849 | Zinc finger C2HC-type containing 1A |
| IL7 protein network | https://string-db.org/network/9606.ENSP00000263851 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs [...] |
| POLR1A protein network | https://string-db.org/network/9606.ENSP00000263857 | DNA-directed RNA polymerase I subunit RPA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalyt [...] |
| GNLY protein network | https://string-db.org/network/9606.ENSP00000263863 | Granulysin; Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Myc [...] |
| VAMP8 protein network | https://string-db.org/network/9606.ENSP00000263864 | Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized o [...] |
| CAPG protein network | https://string-db.org/network/9606.ENSP00000263867 | Macrophage-capping protein; Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrop [...] |
| MAP4K3 protein network | https://string-db.org/network/9606.ENSP00000263881 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway; Mitogen-activated protein [...] |
| USE1 protein network | https://string-db.org/network/9606.ENSP00000263897 | Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; SNAREs |
| STAM2 protein network | https://string-db.org/network/9606.ENSP00000263904 | Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leadi [...] |
| GRB14 protein network | https://string-db.org/network/9606.ENSP00000263915 | Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the act [...] |
| STRN protein network | https://string-db.org/network/9606.ENSP00000263918 | Striatin; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling; Belongs to the WD repeat striatin family |
| CHIC2 protein network | https://string-db.org/network/9606.ENSP00000263921 | Cysteine-rich hydrophobic domain-containing protein 2; Cysteine rich hydrophobic domain 2; Belongs to the CHIC family |
| KDR protein network | https://string-db.org/network/9606.ENSP00000263923 | Vascular endothelial growth factor receptor 2; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, [...] |
| LNX1 protein network | https://string-db.org/network/9606.ENSP00000263925 | E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquiti [...] |
| TNFRSF8 protein network | https://string-db.org/network/9606.ENSP00000263932 | Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene e [...] |
| KIF1B protein network | https://string-db.org/network/9606.ENSP00000263934 | Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis; Kinesins |
| PKP1 protein network | https://string-db.org/network/9606.ENSP00000263946 | Plakophilin-1; Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis; Armadillo repeat containing |
| STK17B protein network | https://string-db.org/network/9606.ENSP00000263955 | Serine/threonine-protein kinase 17B; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein [...] |
| GTF3C3 protein network | https://string-db.org/network/9606.ENSP00000263956 | General transcription factor 3C polypeptide 3; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...] |
| COQ10B protein network | https://string-db.org/network/9606.ENSP00000263960 | Coenzyme Q-binding protein COQ10 homolog B, mitochondrial; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 fro [...] |
| USP13 protein network | https://string-db.org/network/9606.ENSP00000263966 | Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autopha [...] |
| PIK3CA protein network | https://string-db.org/network/9606.ENSP00000263967 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol [...] |
| TAF12 protein network | https://string-db.org/network/9606.ENSP00000263974 | Transcription initiation factor TFIID subunit 12; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs compo [...] |
| SLC9A1 protein network | https://string-db.org/network/9606.ENSP00000263980 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| GATB protein network | https://string-db.org/network/9606.ENSP00000263985 | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...] |
| EHBP1 protein network | https://string-db.org/network/9606.ENSP00000263991 | EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle tr [...] |
| SLC7A6OS protein network | https://string-db.org/network/9606.ENSP00000263997 | Probable RNA polymerase II nuclear localization protein SLC7A6OS; Directs RNA polymerase II nuclear import |
| CKLF protein network | https://string-db.org/network/9606.ENSP00000264001 | Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10 |
| LCAT protein network | https://string-db.org/network/9606.ENSP00000264005 | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts chole [...] |
| HSF4 protein network | https://string-db.org/network/9606.ENSP00000264009 | Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription |
| CTCF protein network | https://string-db.org/network/9606.ENSP00000264010 | Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing intera [...] |
| CDH3 protein network | https://string-db.org/network/9606.ENSP00000264012 | Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| IFT46 protein network | https://string-db.org/network/9606.ENSP00000264020 | Intraflagellar transport proteins; Cilia and flagella associated |
| PVRL1 protein network | https://string-db.org/network/9606.ENSP00000264025 | Nectin-1; Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. [...] |
| SC5D protein network | https://string-db.org/network/9606.ENSP00000264027 | Lathosterol oxidase; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol; Belongs to the sterol desaturase family |
| ARCN1 protein network | https://string-db.org/network/9606.ENSP00000264028 | Coatomer subunit delta; Component of the coatomer, a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further media [...] |
| TREH protein network | https://string-db.org/network/9606.ENSP00000264029 | Trehalase; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose; Belongs to the glycosyl hydrolase 37 family |
| UPK2 protein network | https://string-db.org/network/9606.ENSP00000264031 | Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating t [...] |
| CBL protein network | https://string-db.org/network/9606.ENSP00000264033 | E3 ubiquitin-protein ligase CBL; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiqui [...] |
| MCAM protein network | https://string-db.org/network/9606.ENSP00000264036 | Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells [...] |
| GPC1 protein network | https://string-db.org/network/9606.ENSP00000264039 | Glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). Ma [...] |
| FARP2 protein network | https://string-db.org/network/9606.ENSP00000264042 | FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to cla [...] |
| SLC5A7 protein network | https://string-db.org/network/9606.ENSP00000264047 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space into the neuron with high affinity. Choline uptake is the rate-limiting step in ac [...] |
| NGEF protein network | https://string-db.org/network/9606.ENSP00000264051 | Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone [...] |
| DGKD protein network | https://string-db.org/network/9606.ENSP00000264057 | Diacylglycerol kinase delta; May function as signaling molecule; Diacylglycerol kinases |
| EFHD1 protein network | https://string-db.org/network/9606.ENSP00000264059 | EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production. May play a rol [...] |
| DNAJC10 protein network | https://string-db.org/network/9606.ENSP00000264065 | DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient foldin [...] |
| TUBB4A protein network | https://string-db.org/network/9606.ENSP00000264071 | Tubulin beta-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...] |
| FCER2 protein network | https://string-db.org/network/9606.ENSP00000264072 | Low affinity immunoglobulin epsilon Fc receptor; Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation [...] |
| MCOLN1 protein network | https://string-db.org/network/9606.ENSP00000264079 | Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from la [...] |
| GPR108 protein network | https://string-db.org/network/9606.ENSP00000264080 | G protein-coupled receptor 108; 7TM orphan receptors |
| DGUOK protein network | https://string-db.org/network/9606.ENSP00000264093 | Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where [...] |
| LOXL3 protein network | https://string-db.org/network/9606.ENSP00000264094 | Lysyl oxidase homolog 3; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post- translational oxidative deamination o [...] |
| HAT1 protein network | https://string-db.org/network/9606.ENSP00000264108 | Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at [...] |
| ATF2 protein network | https://string-db.org/network/9606.ENSP00000264110 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti- apoptosis, cell growth, and DNA da [...] |
| CBLB protein network | https://string-db.org/network/9606.ENSP00000264122 | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their de [...] |
| LAMC2 protein network | https://string-db.org/network/9606.ENSP00000264144 | Laminin subunit gamma-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| OSGEPL1 protein network | https://string-db.org/network/9606.ENSP00000264151 | Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that r [...] |
| MCM6 protein network | https://string-db.org/network/9606.ENSP00000264156 | DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| CCNT2 protein network | https://string-db.org/network/9606.ENSP00000264157 | Cyclin-T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the tra [...] |
| ZRANB3 protein network | https://string-db.org/network/9606.ENSP00000264159 | DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restar [...] |
| DARS protein network | https://string-db.org/network/9606.ENSP00000264161 | Aspartate--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...] |
| LCT protein network | https://string-db.org/network/9606.ENSP00000264162 | Lactase-phlorizin hydrolase; LPH splits lactose in the small intestine |
| AGPS protein network | https://string-db.org/network/9606.ENSP00000264167 | Alkyldihydroxyacetonephosphate synthase, peroxisomal; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids [...] |
| KYNU protein network | https://string-db.org/network/9606.ENSP00000264170 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preferen [...] |
| ARID4B protein network | https://string-db.org/network/9606.ENSP00000264183 | AT-rich interactive domain-containing protein 4B; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating inte [...] |
| NID1 protein network | https://string-db.org/network/9606.ENSP00000264187 | Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellula [...] |
| CYTIP protein network | https://string-db.org/network/9606.ENSP00000264192 | Cytohesin-interacting protein; By its binding to cytohesin-1 (CYTH1), it modifies activation of ARFs by CYTH1 and its precise function may be to sequester CYTH1 in the cytoplasm; PDZ domain conta [...] |
| CPOX protein network | https://string-db.org/network/9606.ENSP00000264193 | Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of copropo [...] |
| MUL1 protein network | https://string-db.org/network/9606.ENSP00000264198 | Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form o [...] |
| NMU protein network | https://string-db.org/network/9606.ENSP00000264218 | Neuromedin-U; Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder; Belongs to the NmU family |
| PPAT protein network | https://string-db.org/network/9606.ENSP00000264220 | Amidophosphoribosyltransferase; Phosphoribosyl pyrophosphate amidotransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family |
| SRD5A3 protein network | https://string-db.org/network/9606.ENSP00000264228 | Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis [...] |
| NOA1 protein network | https://string-db.org/network/9606.ENSP00000264230 | Nitric oxide-associated protein 1; Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein [...] |
| POPDC2 protein network | https://string-db.org/network/9606.ENSP00000264231 | Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, pro [...] |
| POLQ protein network | https://string-db.org/network/9606.ENSP00000264233 | DNA polymerase theta; DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand br [...] |
| UPK1B protein network | https://string-db.org/network/9606.ENSP00000264234 | Uroplakin-1b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal blad [...] |
| ARHGAP31 protein network | https://string-db.org/network/9606.ENSP00000264245 | Rho GTPase-activating protein 31; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration |
| CD80 protein network | https://string-db.org/network/9606.ENSP00000264246 | T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, [...] |
| CHST10 protein network | https://string-db.org/network/9606.ENSP00000264249 | Carbohydrate sulfotransferase 10; Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of H [...] |
| PDCL3 protein network | https://string-db.org/network/9606.ENSP00000264254 | Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, controlling its abundance and inhibiting its ubiquitination and degradation. Modulates the activation of [...] |
| TXNDC9 protein network | https://string-db.org/network/9606.ENSP00000264255 | Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin |
| IL1RL2 protein network | https://string-db.org/network/9606.ENSP00000264257 | Interleukin-1 receptor-like 2; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor comp [...] |
| IL18RAP protein network | https://string-db.org/network/9606.ENSP00000264260 | Interleukin-18 receptor accessory protein; Within the IL18 receptor complex, does not mediate IL18- binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK acti [...] |
| LXN protein network | https://string-db.org/network/9606.ENSP00000264265 | Latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation; Belongs to the protease inhibitor I47 (latexin) family |
| ALS2 protein network | https://string-db.org/network/9606.ENSP00000264276 | Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity); Rho guanine nucleotide exchange factors |
| NOP58 protein network | https://string-db.org/network/9606.ENSP00000264279 | Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of [...] |
| SLAIN2 protein network | https://string-db.org/network/9606.ENSP00000264313 | SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation [...] |
| TXK protein network | https://string-db.org/network/9606.ENSP00000264316 | Tyrosine-protein kinase TXK; Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiati [...] |
| GABRA4 protein network | https://string-db.org/network/9606.ENSP00000264318 | Gamma-aminobutyric acid receptor subunit alpha-4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| YWHAE protein network | https://string-db.org/network/9606.ENSP00000264335 | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recogn [...] |
| FAM13A protein network | https://string-db.org/network/9606.ENSP00000264344 | Protein FAM13A; Family with sequence similarity 13 member A; Belongs to the FAM13 family |
| HERC6 protein network | https://string-db.org/network/9606.ENSP00000264346 | Probable E3 ubiquitin-protein ligase HERC6; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...] |
| HERC5 protein network | https://string-db.org/network/9606.ENSP00000264350 | E3 ISG15--protein ligase HERC5; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Functions as part of the ISGylatio [...] |
| PCDH10 protein network | https://string-db.org/network/9606.ENSP00000264360 | Protocadherin-10; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| NDST4 protein network | https://string-db.org/network/9606.ENSP00000264363 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...] |
| CRYGD protein network | https://string-db.org/network/9606.ENSP00000264376 | Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens |
| ADAM23 protein network | https://string-db.org/network/9606.ENSP00000264377 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein; ADAM metallopeptid [...] |
| PIKFYVE protein network | https://string-db.org/network/9606.ENSP00000264380 | 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the pho [...] |
| BCHE protein network | https://string-db.org/network/9606.ENSP00000264381 | Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the typ [...] |
| SI protein network | https://string-db.org/network/9606.ENSP00000264382 | Sucrase-isomaltase, intestinal; Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides; Belongs t [...] |
| C2orf83 protein network | https://string-db.org/network/9606.ENSP00000264387 | Folate transporter-like protein C2orf83; Chromosome 2 open reading frame 83 |
| COPS4 protein network | https://string-db.org/network/9606.ENSP00000264389 | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| PRKG2 protein network | https://string-db.org/network/9606.ENSP00000264399 | cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth (By similarity). Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestina [...] |
| RASGEF1B protein network | https://string-db.org/network/9606.ENSP00000264400 | Ras-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro) |
| CUL3 protein network | https://string-db.org/network/9606.ENSP00000264414 | Cullin-3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target [...] |
| GUCY1B3 protein network | https://string-db.org/network/9606.ENSP00000264424 | Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP; Belongs to the adenylyl cyclase class-4/guanylyl c [...] |
| GLRB protein network | https://string-db.org/network/9606.ENSP00000264428 | Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride chann [...] |
| RAPGEF2 protein network | https://string-db.org/network/9606.ENSP00000264431 | Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cA [...] |
| FNIP2 protein network | https://string-db.org/network/9606.ENSP00000264433 | Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client pr [...] |
| C2orf42 protein network | https://string-db.org/network/9606.ENSP00000264434 | Uncharacterized protein C2orf42; Chromosome 2 open reading frame 42 |
| ADD2 protein network | https://string-db.org/network/9606.ENSP00000264436 | Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide [...] |
| MXD1 protein network | https://string-db.org/network/9606.ENSP00000264444 | Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus anta [...] |
| SLC30A9 protein network | https://string-db.org/network/9606.ENSP00000264451 | Zinc transporter 9; Acts as a zinc transporter involved in intracellular zinc homeostasis. Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtype [...] |
| SEC22C protein network | https://string-db.org/network/9606.ENSP00000264454 | Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs |
| CDH10 protein network | https://string-db.org/network/9606.ENSP00000264463 | Cadherin-10; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| CSTA protein network | https://string-db.org/network/9606.ENSP00000264474 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis; Belongs to the cystatin famil [...] |
| IL21 protein network | https://string-db.org/network/9606.ENSP00000264497 | Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). M [...] |
| FGF2 protein network | https://string-db.org/network/9606.ENSP00000264498 | Fibroblast growth factor 2; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. [...] |
| BBS7 protein network | https://string-db.org/network/9606.ENSP00000264499 | Bardet-Biedl syndrome 7 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...] |
| KIAA1109 protein network | https://string-db.org/network/9606.ENSP00000264501 | Uncharacterized protein KIAA1109; KIAA1109 |
| RBBP5 protein network | https://string-db.org/network/9606.ENSP00000264515 | Retinoblastoma-binding protein 5; In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys [...] |
| IFT57 protein network | https://string-db.org/network/9606.ENSP00000264538 | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway [...] |
| UBE2S protein network | https://string-db.org/network/9606.ENSP00000264552 | Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essentia [...] |
| GZMM protein network | https://string-db.org/network/9606.ENSP00000264553 | Granzyme M; Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha- tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspas [...] |
| SHC2 protein network | https://string-db.org/network/9606.ENSP00000264554 | SHC-transforming protein 2; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activate [...] |
| PHRF1 protein network | https://string-db.org/network/9606.ENSP00000264555 | PHD and RING finger domain-containing protein 1; Protein phosphatase 1 regulatory subunits; PHD finger proteins |
| IL11 protein network | https://string-db.org/network/9606.ENSP00000264563 | Interleukin-11; Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet prod [...] |
| AGA protein network | https://string-db.org/network/9606.ENSP00000264595 | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins; Belongs to the Ntn-hydrolase family |
| NEIL3 protein network | https://string-db.org/network/9606.ENSP00000264596 | Endonuclease 8-like 3; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displ [...] |
| RAB17 protein network | https://string-db.org/network/9606.ENSP00000264601 | Ras-related protein Rab-17; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| MLPH protein network | https://string-db.org/network/9606.ENSP00000264605 | Melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A |
| HDAC4 protein network | https://string-db.org/network/9606.ENSP00000264606 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| ASB1 protein network | https://string-db.org/network/9606.ENSP00000264607 | Ankyrin repeat and SOCS box protein 1; May play a role in testis development (By similarity). Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligas [...] |
| CP protein network | https://string-db.org/network/9606.ENSP00000264613 | Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It i [...] |
| WNT5A protein network | https://string-db.org/network/9606.ENSP00000264634 | Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4 [...] |
| THRA protein network | https://string-db.org/network/9606.ENSP00000264637 | Thyroid hormone receptor alpha; Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodo [...] |
| CNTNAP1 protein network | https://string-db.org/network/9606.ENSP00000264638 | Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for sal [...] |
| PSMD3 protein network | https://string-db.org/network/9606.ENSP00000264639 | 26S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| RAPGEFL1 protein network | https://string-db.org/network/9606.ENSP00000264644 | Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF) |
| CASC3 protein network | https://string-db.org/network/9606.ENSP00000264645 | Protein CASC3; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins [...] |
| ATP6V0A1 protein network | https://string-db.org/network/9606.ENSP00000264649 | V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific o [...] |
| KRT24 protein network | https://string-db.org/network/9606.ENSP00000264651 | Keratin, type I cytoskeletal 24; Keratins, type I |
| STAT3 protein network | https://string-db.org/network/9606.ENSP00000264657 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once a [...] |
| FBXL20 protein network | https://string-db.org/network/9606.ENSP00000264658 | F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity); F-box and leucine [...] |
| KCNH4 protein network | https://string-db.org/network/9606.ENSP00000264661 | Potassium voltage-gated channel subfamily H member 4; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties ma [...] |
| NNT protein network | https://string-db.org/network/9606.ENSP00000264663 | NAD(P) transhydrogenase, mitochondrial; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a ro [...] |
| FGF10 protein network | https://string-db.org/network/9606.ENSP00000264664 | Fibroblast growth factor 10; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play [...] |
| MTRR protein network | https://string-db.org/network/9606.ENSP00000264668 | Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary f [...] |
| FASTKD3 protein network | https://string-db.org/network/9606.ENSP00000264669 | FAST kinase domain-containing protein 3, mitochondrial; Required for normal mitochondrial respiration; Belongs to the FAST kinase family |
| NSUN2 protein network | https://string-db.org/network/9606.ENSP00000264670 | tRNA (cytosine(34)-C(5))-methyltransferase; RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5- methylcytosine (m5C) at positions 3 [...] |
| MECOM protein network | https://string-db.org/network/9606.ENSP00000264674 | MDS1 and EVI1 complex locus protein EVI1; Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their ex [...] |
| UFSP2 protein network | https://string-db.org/network/9606.ENSP00000264689 | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Do [...] |
| KLKB1 protein network | https://string-db.org/network/9606.ENSP00000264690 | Plasma kallikrein; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin [...] |
| FNDC4 protein network | https://string-db.org/network/9606.ENSP00000264703 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expressio [...] |
| CAD protein network | https://string-db.org/network/9606.ENSP00000264705 | CAD protein; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase); In the central section; belongs to the metallo- d [...] |
| DNMT3A protein network | https://string-db.org/network/9606.ENSP00000264709 | DNA (cytosine-5)-methyltransferase 3A; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coord [...] |
| RAB10 protein network | https://string-db.org/network/9606.ENSP00000264710 | Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| DNAJC27 protein network | https://string-db.org/network/9606.ENSP00000264711 | DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by associati [...] |
| KIF3C protein network | https://string-db.org/network/9606.ENSP00000264712 | Kinesin-like protein KIF3C; Microtubule-based anterograde translocator for membranous organelles; Kinesins |
| FOSL2 protein network | https://string-db.org/network/9606.ENSP00000264716 | Fos-related antigen 2; Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts; Basic leucine zipper p [...] |
| GCKR protein network | https://string-db.org/network/9606.ENSP00000264717 | Glucokinase regulatory protein; Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fruc [...] |
| GPN1 protein network | https://string-db.org/network/9606.ENSP00000264718 | GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA poly [...] |
| TP63 protein network | https://string-db.org/network/9606.ENSP00000264731 | Tumor protein 63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibit [...] |
| CLDN16 protein network | https://string-db.org/network/9606.ENSP00000264734 | Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorp [...] |
| HRASLS protein network | https://string-db.org/network/9606.ENSP00000264735 | Phospholipid-metabolizing enzyme A-C1; Exhibits calcium-independent phospholipase activity towards phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Also shows acyltransferase activitie [...] |
| ITGA9 protein network | https://string-db.org/network/9606.ENSP00000264741 | Integrin alpha-9; Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E- I-D-G-I-E-L in cytotactin |
| ADD1 protein network | https://string-db.org/network/9606.ENSP00000264758 | Alpha-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin |
| TMEM175 protein network | https://string-db.org/network/9606.ENSP00000264771 | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak [...] |
| PPAP2A protein network | https://string-db.org/network/9606.ENSP00000264775 | Phospholipid phosphatase 1; Phosphatidic acid phosphatase type 2A |
| GPBP1 protein network | https://string-db.org/network/9606.ENSP00000264779 | Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor; Belongs to the vasculin family |
| SLC2A9 protein network | https://string-db.org/network/9606.ENSP00000264784 | Solute carrier family 2, facilitated glucose transporter member 9; Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate [...] |
| PRDM5 protein network | https://string-db.org/network/9606.ENSP00000264808 | PR domain zinc finger protein 5; Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone [...] |
| MIER2 protein network | https://string-db.org/network/9606.ENSP00000264819 | Mesoderm induction early response protein 2; Transcriptional repressor; Myb/SANT domain containing |
| LYL1 protein network | https://string-db.org/network/9606.ENSP00000264824 | Protein lyl-1; LYL1, basic helix-loop-helix family member |
| COL5A3 protein network | https://string-db.org/network/9606.ENSP00000264828 | Collagen alpha-3(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...] |
| ICAM1 protein network | https://string-db.org/network/9606.ENSP00000264832 | Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans- endothelial migration, ICAM1 engagement pr [...] |
| OLFM2 protein network | https://string-db.org/network/9606.ENSP00000264833 | Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SR [...] |
| KLF1 protein network | https://string-db.org/network/9606.ENSP00000264834 | Krueppel-like factor 1; Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin swit [...] |
| SIDT1 protein network | https://string-db.org/network/9606.ENSP00000264852 | SID1 transmembrane family member 1; In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which [...] |
| PI4K2B protein network | https://string-db.org/network/9606.ENSP00000264864 | Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be [...] |
| TBC1D19 protein network | https://string-db.org/network/9606.ENSP00000264866 | TBC1 domain family member 19; May act as a GTPase-activating protein for Rab family protein(s) |
| PPARGC1A protein network | https://string-db.org/network/9606.ENSP00000264867 | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PP [...] |
| F13A1 protein network | https://string-db.org/network/9606.ENSP00000264870 | Coagulation factor XIII A chain; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibr [...] |
| NUP54 protein network | https://string-db.org/network/9606.ENSP00000264883 | Nucleoporin p54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Nucleoporins |
| SEPT11 protein network | https://string-db.org/network/9606.ENSP00000264893 | Septin-11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spi [...] |
| SCARB2 protein network | https://string-db.org/network/9606.ENSP00000264896 | Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting; Belongs to the CD36 family |
| ANXA3 protein network | https://string-db.org/network/9606.ENSP00000264908 | Annexin A3; Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate; Annexins |
| ARSB protein network | https://string-db.org/network/9606.ENSP00000264914 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation. Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithel [...] |
| PDE8B protein network | https://string-db.org/network/9606.ENSP00000264917 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May b [...] |
| RAD18 protein network | https://string-db.org/network/9606.ENSP00000264926 | E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on repli [...] |
| SLC12A7 protein network | https://string-db.org/network/9606.ENSP00000264930 | Solute carrier family 12 member 7; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribut [...] |
| SDHA protein network | https://string-db.org/network/9606.ENSP00000264932 | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron t [...] |
| PDCD6 protein network | https://string-db.org/network/9606.ENSP00000264933 | Programmed cell death protein 6; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as a [...] |
| CEP72 protein network | https://string-db.org/network/9606.ENSP00000264935 | Centrosomal protein of 72 kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes [...] |
| SLC9A3 protein network | https://string-db.org/network/9606.ENSP00000264938 | Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| XRN1 protein network | https://string-db.org/network/9606.ENSP00000264951 | 5'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is [...] |
| GRK7 protein network | https://string-db.org/network/9606.ENSP00000264952 | Rhodopsin kinase; Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO) |
| GRPEL1 protein network | https://string-db.org/network/9606.ENSP00000264954 | GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mit [...] |
| EVC protein network | https://string-db.org/network/9606.ENSP00000264956 | Ellis-van Creveld syndrome protein; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development |
| MGAT4A protein network | https://string-db.org/network/9606.ENSP00000264968 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- [...] |
| ZAP70 protein network | https://string-db.org/network/9606.ENSP00000264972 | Tyrosine-protein kinase ZAP-70; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, [...] |
| PPP2R3A protein network | https://string-db.org/network/9606.ENSP00000264977 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the local [...] |
| CEP70 protein network | https://string-db.org/network/9606.ENSP00000264982 | Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of [...] |
| ACAD11 protein network | https://string-db.org/network/9606.ENSP00000264990 | Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA |
| CDV3 protein network | https://string-db.org/network/9606.ENSP00000264993 | CDV3 homolog |
| MRPL3 protein network | https://string-db.org/network/9606.ENSP00000264995 | Mitochondrial ribosomal protein L3 |
| GALNT7 protein network | https://string-db.org/network/9606.ENSP00000265000 | N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already [...] |
| SOX30 protein network | https://string-db.org/network/9606.ENSP00000265007 | Transcription factor SOX-30; Transcriptional activator. Binds to the DNA sequence 5'- ACAAT-3' and shows a preference for guanine residues surrounding this core motif; SRY-boxes |
| BST1 protein network | https://string-db.org/network/9606.ENSP00000265016 | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits cal [...] |
| FAM184B protein network | https://string-db.org/network/9606.ENSP00000265018 | Protein FAM184B; Family with sequence similarity 184 member B; Belongs to the FAM184 family |
| DGKG protein network | https://string-db.org/network/9606.ENSP00000265022 | Diacylglycerol kinase gamma; Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid; Belongs to the eukaryotic diacylglycerol kinase fam [...] |
| KNG1 protein network | https://string-db.org/network/9606.ENSP00000265023 | Kininogen-1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to [...] |
| MAP3K13 protein network | https://string-db.org/network/9606.ENSP00000265026 | Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activat [...] |
| FETUB protein network | https://string-db.org/network/9606.ENSP00000265029 | Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a p [...] |
| DEPDC1B protein network | https://string-db.org/network/9606.ENSP00000265036 | DEP domain containing 1B |
| ERCC8 protein network | https://string-db.org/network/9606.ENSP00000265038 | DNA excision repair protein ERCC-8; Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide e [...] |
| SSR3 protein network | https://string-db.org/network/9606.ENSP00000265044 | Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; B [...] |
| MGLL protein network | https://string-db.org/network/9606.ENSP00000265052 | Monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabi [...] |
| MCM2 protein network | https://string-db.org/network/9606.ENSP00000265056 | DNA replication licensing factor MCM2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| RAB7A protein network | https://string-db.org/network/9606.ENSP00000265062 | Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and pos [...] |
| KIAA1257 protein network | https://string-db.org/network/9606.ENSP00000265068 | Uncharacterized protein KIAA1257; KIAA1257 |
| ZFR protein network | https://string-db.org/network/9606.ENSP00000265069 | Zinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development. Involved in the nucleocytoplasmic shuttling of STAU2. Binds to DNA and RNA (By similarity) |
| GOLPH3 protein network | https://string-db.org/network/9606.ENSP00000265070 | Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from [...] |
| CDH6 protein network | https://string-db.org/network/9606.ENSP00000265071 | Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| SUB1 protein network | https://string-db.org/network/9606.ENSP00000265073 | Activated RNA polymerase II transcriptional coactivator p15; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the ge [...] |
| NPR3 protein network | https://string-db.org/network/9606.ENSP00000265074 | Atrial natriuretic peptide receptor 3; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and [...] |
| VCAN protein network | https://string-db.org/network/9606.ENSP00000265077 | Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiati [...] |
| RASGRF2 protein network | https://string-db.org/network/9606.ENSP00000265080 | Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentia [...] |
| MSH3 protein network | https://string-db.org/network/9606.ENSP00000265081 | DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating [...] |
| CPEB4 protein network | https://string-db.org/network/9606.ENSP00000265085 | Cytoplasmic polyadenylation element-binding protein 4; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consens [...] |
| STC2 protein network | https://string-db.org/network/9606.ENSP00000265087 | Stanniocalcin-2; Has an anti-hypocalcemic action on calcium and phosphate homeostasis; Belongs to the stanniocalcin family |
| FBXW11 protein network | https://string-db.org/network/9606.ENSP00000265094 | F-box/WD repeat-containing protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent pro [...] |
| THOC3 protein network | https://string-db.org/network/9606.ENSP00000265097 | THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcript [...] |
| DNAH5 protein network | https://string-db.org/network/9606.ENSP00000265104 | Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| WDR70 protein network | https://string-db.org/network/9606.ENSP00000265107 | WD repeat-containing protein 70; WD repeat domain containing; Belongs to the WD repeat GAD-1 family |
| SLC1A3 protein network | https://string-db.org/network/9606.ENSP00000265113 | Excitatory amino acid transporter 1; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...] |
| TNC protein network | https://string-db.org/network/9606.ENSP00000265131 | Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outg [...] |
| AMBP protein network | https://string-db.org/network/9606.ENSP00000265132 | Protein AMBP; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; Lipocalins |
| ARRDC3 protein network | https://string-db.org/network/9606.ENSP00000265138 | Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell- surface expression of adrenergic receptors and probably also other G protein-coupled receptors. Plays a [...] |
| ANKRD32 protein network | https://string-db.org/network/9606.ENSP00000265140 | SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. Th [...] |
| CENPE protein network | https://string-db.org/network/9606.ENSP00000265148 | Centromere-associated protein E; Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule- kinetochore conjugation and spindle assembly [...] |
| ENPEP protein network | https://string-db.org/network/9606.ENSP00000265162 | Glutamyl aminopeptidase; Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells; [...] |
| CASP6 protein network | https://string-db.org/network/9606.ENSP00000265164 | Caspase-6; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed [...] |
| LEF1 protein network | https://string-db.org/network/9606.ENSP00000265165 | Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differenti [...] |
| EGF protein network | https://string-db.org/network/9606.ENSP00000265171 | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimul [...] |
| PAPSS1 protein network | https://string-db.org/network/9606.ENSP00000265174 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. T [...] |
| NME5 protein network | https://string-db.org/network/9606.ENSP00000265191 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes includi [...] |
| IQCG protein network | https://string-db.org/network/9606.ENSP00000265239 | IQ domain-containing protein G; Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin- dependent protein kinase IV (CAMK4) activ [...] |
| LSG1 protein network | https://string-db.org/network/9606.ENSP00000265245 | Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subun [...] |
| PCNP protein network | https://string-db.org/network/9606.ENSP00000265260 | PEST proteolytic signal-containing nuclear protein; May be involved in cell cycle regulation |
| RBM27 protein network | https://string-db.org/network/9606.ENSP00000265271 | RNA-binding protein 27; RNA binding motif containing |
| GPAM protein network | https://string-db.org/network/9606.ENSP00000265276 | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis |
| SPDL1 protein network | https://string-db.org/network/9606.ENSP00000265295 | Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle [...] |
| FAM188B protein network | https://string-db.org/network/9606.ENSP00000265299 | Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins |
| TRPV5 protein network | https://string-db.org/network/9606.ENSP00000265310 | Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Req [...] |
| ABCB6 protein network | https://string-db.org/network/9606.ENSP00000265316 | ATP-binding cassette sub-family B member 6, mitochondrial; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis; Be [...] |
| PECR protein network | https://string-db.org/network/9606.ENSP00000265322 | Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity; Short chain dehydrogenase/reductase superfamily |
| VDAC1 protein network | https://string-db.org/network/9606.ENSP00000265333 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows [...] |
| CDKL3 protein network | https://string-db.org/network/9606.ENSP00000265334 | Cyclin-dependent kinase-like 3; Cyclin dependent kinase like 3 |
| UBE2B protein network | https://string-db.org/network/9606.ENSP00000265339 | Ubiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it p [...] |
| PITX1 protein network | https://string-db.org/network/9606.ENSP00000265340 | Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particu [...] |
| FSTL4 protein network | https://string-db.org/network/9606.ENSP00000265342 | Follistatin-related protein 4; Immunoglobulin like domain containing |
| AFF4 protein network | https://string-db.org/network/9606.ENSP00000265343 | AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausin [...] |
| MED20 protein network | https://string-db.org/network/9606.ENSP00000265350 | Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| XPO5 protein network | https://string-db.org/network/9606.ENSP00000265351 | Exportin-5; Mediates the nuclear export of proteins bearing a double-stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and [...] |
| SRF protein network | https://string-db.org/network/9606.ENSP00000265354 | Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initia [...] |
| SEMA3C protein network | https://string-db.org/network/9606.ENSP00000265361 | Semaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functi [...] |
| SEMA3A protein network | https://string-db.org/network/9606.ENSP00000265362 | Semaphorin-3A; Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that gu [...] |
| NRP1 protein network | https://string-db.org/network/9606.ENSP00000265371 | Neuropilin-1; The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogene [...] |
| CREM protein network | https://string-db.org/network/9606.ENSP00000265372 | cAMP responsive element modulator; Basic leucine zipper proteins |
| COL6A5 protein network | https://string-db.org/network/9606.ENSP00000265379 | Collagen alpha-5(VI) chain; Collagen VI acts as a cell-binding protein; Collagens |
| APBA1 protein network | https://string-db.org/network/9606.ENSP00000265381 | Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic mac [...] |
| PIP5K1B protein network | https://string-db.org/network/9606.ENSP00000265382 | Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contri [...] |
| TNPO3 protein network | https://string-db.org/network/9606.ENSP00000265388 | Transportin-3; Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizin [...] |
| HIBADH protein network | https://string-db.org/network/9606.ENSP00000265395 | 3-hydroxyisobutyrate dehydrogenase, mitochondrial; 3-hydroxyisobutyrate dehydrogenase |
| UGT2B10 protein network | https://string-db.org/network/9606.ENSP00000265403 | UDP-glucuronosyltransferase 2B10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyl [...] |
| STAP1 protein network | https://string-db.org/network/9606.ENSP00000265404 | Signal-transducing adaptor protein 1; In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity o [...] |
| POLB protein network | https://string-db.org/network/9606.ENSP00000265421 | DNA polymerase beta; Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts a [...] |
| CALB1 protein network | https://string-db.org/network/9606.ENSP00000265431 | Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase; EF-hand domain containing |
| NBN protein network | https://string-db.org/network/9606.ENSP00000265433 | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in d [...] |
| ST7 protein network | https://string-db.org/network/9606.ENSP00000265437 | Suppressor of tumorigenicity 7 protein; May act as a tumor suppressor; Belongs to the ST7 family |
| TFEC protein network | https://string-db.org/network/9606.ENSP00000265440 | Transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box s [...] |
| WNT2 protein network | https://string-db.org/network/9606.ENSP00000265441 | Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete re [...] |
| NRXN2 protein network | https://string-db.org/network/9606.ENSP00000265459 | Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins |
| PRDX5 protein network | https://string-db.org/network/9606.ENSP00000265462 | Peroxiredoxin-5, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell pr [...] |
| POLA2 protein network | https://string-db.org/network/9606.ENSP00000265465 | DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery |
| B3GAT3 protein network | https://string-db.org/network/9606.ENSP00000265471 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin su [...] |
| ADH4 protein network | https://string-db.org/network/9606.ENSP00000265512 | Alcohol dehydrogenase 4, pi polypeptide |
| USP4 protein network | https://string-db.org/network/9606.ENSP00000265560 | Ubiquitin carboxyl-terminal hydrolase 4; Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functio [...] |
| PTPN23 protein network | https://string-db.org/network/9606.ENSP00000265562 | Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endoso [...] |
| PRKAR2A protein network | https://string-db.org/network/9606.ENSP00000265563 | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate mem [...] |
| EXOSC7 protein network | https://string-db.org/network/9606.ENSP00000265564 | Exosome complex component RRP42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| SCAP protein network | https://string-db.org/network/9606.ENSP00000265565 | Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER [...] |
| OPRK1 protein network | https://string-db.org/network/9606.ENSP00000265572 | Kappa-type opioid receptor; G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also function [...] |
| CLCN2 protein network | https://string-db.org/network/9606.ENSP00000265593 | Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction [...] |
| MCCC1 protein network | https://string-db.org/network/9606.ENSP00000265594 | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA t [...] |
| LAMP3 protein network | https://string-db.org/network/9606.ENSP00000265598 | Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity; CD molecules |
| ALDH8A1 protein network | https://string-db.org/network/9606.ENSP00000265605 | Aldehyde dehydrogenase family 8 member A1; Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest [...] |
| PON3 protein network | https://string-db.org/network/9606.ENSP00000265627 | Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hyd [...] |
| NPTX2 protein network | https://string-db.org/network/9606.ENSP00000265634 | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity) |
| CPT1A protein network | https://string-db.org/network/9606.ENSP00000265641 | Carnitine O-palmitoyltransferase 1, liver isoform; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake [...] |
| GAL protein network | https://string-db.org/network/9606.ENSP00000265643 | Galanin peptides; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may reg [...] |
| FBXO3 protein network | https://string-db.org/network/9606.ENSP00000265651 | F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, lead [...] |
| TCIRG1 protein network | https://string-db.org/network/9606.ENSP00000265686 | V-type proton ATPase 116 kDa subunit a isoform 3; Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation; Belongs to the V-ATPase 116 kDa subu [...] |
| CHKA protein network | https://string-db.org/network/9606.ENSP00000265689 | Choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidy [...] |
| ADAM18 protein network | https://string-db.org/network/9606.ENSP00000265707 | Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-l [...] |
| ADAM2 protein network | https://string-db.org/network/9606.ENSP00000265708 | Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could hav [...] |
| ANK1 protein network | https://string-db.org/network/9606.ENSP00000265709 | Ankyrin-1; Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cy [...] |
| SLC26A4 protein network | https://string-db.org/network/9606.ENSP00000265715 | Pendrin; Sodium-independent transporter of chloride and iodide; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family |
| PRKAR2B protein network | https://string-db.org/network/9606.ENSP00000265717 | cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate memb [...] |
| DUS4L protein network | https://string-db.org/network/9606.ENSP00000265720 | tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs |
| ABCB4 protein network | https://string-db.org/network/9606.ENSP00000265723 | Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates s [...] |
| ADAM22 protein network | https://string-db.org/network/9606.ENSP00000265727 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adh [...] |
| DBF4 protein network | https://string-db.org/network/9606.ENSP00000265728 | Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S pha [...] |
| SRI protein network | https://string-db.org/network/9606.ENSP00000265729 | Sorcin; Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR [...] |
| RBM48 protein network | https://string-db.org/network/9606.ENSP00000265732 | RNA-binding protein 48; RNA binding motif containing |
| CDK6 protein network | https://string-db.org/network/9606.ENSP00000265734 | Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with [...] |
| ANKIB1 protein network | https://string-db.org/network/9606.ENSP00000265742 | Ankyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin- conjugating enzymes [...] |
| ANLN protein network | https://string-db.org/network/9606.ENSP00000265748 | Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase a [...] |
| EIF4H protein network | https://string-db.org/network/9606.ENSP00000265753 | Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA; RNA binding motif containing |
| ADAM28 protein network | https://string-db.org/network/9606.ENSP00000265769 | Disintegrin and metalloproteinase domain-containing protein 28; May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain sheddi [...] |
| SMARCA2 protein network | https://string-db.org/network/9606.ENSP00000265773 | Probable global transcription activator SNF2L2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of [...] |
| R3HCC1 protein network | https://string-db.org/network/9606.ENSP00000265806 | R3H domain and coiled-coil containing 1 |
| SH2D4A protein network | https://string-db.org/network/9606.ENSP00000265807 | SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced [...] |
| FSCN3 protein network | https://string-db.org/network/9606.ENSP00000265825 | Fascin-3; Acts as an actin bundling protein; Belongs to the fascin family |
| ACAT1 protein network | https://string-db.org/network/9606.ENSP00000265838 | Acetyl-CoA acetyltransferase, mitochondrial; Plays a major role in ketone body metabolism |
| ELMOD1 protein network | https://string-db.org/network/9606.ENSP00000265840 | ELMO domain-containing protein 1; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family |
| EXPH5 protein network | https://string-db.org/network/9606.ENSP00000265843 | Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking |
| PMS2 protein network | https://string-db.org/network/9606.ENSP00000265849 | Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MS [...] |
| GET4 protein network | https://string-db.org/network/9606.ENSP00000265857 | Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble [...] |
| HNRNPH3 protein network | https://string-db.org/network/9606.ENSP00000265866 | Heterogeneous nuclear ribonucleoprotein H3; Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different i [...] |
| CCAR1 protein network | https://string-db.org/network/9606.ENSP00000265872 | Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals [...] |
| REXO2 protein network | https://string-db.org/network/9606.ENSP00000265881 | Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. M [...] |
| SQLE protein network | https://string-db.org/network/9606.ENSP00000265896 | Squalene monooxygenase; Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway; Belongs to the squalene monooxygenase [...] |
| SNX19 protein network | https://string-db.org/network/9606.ENSP00000265909 | Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin-containing dense core vesicles in pancreatic beta-cells and in preventin [...] |
| BRINP1 protein network | https://string-db.org/network/9606.ENSP00000265922 | BMP/retinoic acid-inducible neural-specific protein 1; Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type [...] |
| MYO3A protein network | https://string-db.org/network/9606.ENSP00000265944 | Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing. Required for normal cochlear hair bundle development and hearing. Plays an imp [...] |
| MAPKAP1 protein network | https://string-db.org/network/9606.ENSP00000265960 | Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast [...] |
| GTF2H1 protein network | https://string-db.org/network/9606.ENSP00000265963 | General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcrip [...] |
| SERGEF protein network | https://string-db.org/network/9606.ENSP00000265965 | Secretion-regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process |
| HPS5 protein network | https://string-db.org/network/9606.ENSP00000265967 | Hermansky-Pudlak syndrome 5 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracel [...] |
| KCNC1 protein network | https://string-db.org/network/9606.ENSP00000265969 | Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in r [...] |
| PIK3C2A protein network | https://string-db.org/network/9606.ENSP00000265970 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that [...] |
| FAM160A2 protein network | https://string-db.org/network/9606.ENSP00000265978 | FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular prote [...] |
| RNF141 protein network | https://string-db.org/network/9606.ENSP00000265981 | RING finger protein 141; May be involved in spermatogenesis; Ring finger proteins |
| HPX protein network | https://string-db.org/network/9606.ENSP00000265983 | Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation |
| IDE protein network | https://string-db.org/network/9606.ENSP00000265986 | Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. [...] |
| BTAF1 protein network | https://string-db.org/network/9606.ENSP00000265990 | TATA-binding protein-associated factor 172; Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner; Belongs to the SNF2/R [...] |
| GLT8D1 protein network | https://string-db.org/network/9606.ENSP00000266014 | Glycosyltransferase 8 domain containing 1; Belongs to the glycosyltransferase 8 family |
| RBM6 protein network | https://string-db.org/network/9606.ENSP00000266022 | RNA-binding protein 6; Specifically binds poly(G) RNA homopolymers in vitro; G-patch domain containing |
| TMEM115 protein network | https://string-db.org/network/9606.ENSP00000266025 | Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi; Rhomb [...] |
| HYAL1 protein network | https://string-db.org/network/9606.ENSP00000266031 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth |
| DOCK3 protein network | https://string-db.org/network/9606.ENSP00000266037 | Dedicator of cytokinesis protein 3; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with preseni [...] |
| ITIH4 protein network | https://string-db.org/network/9606.ENSP00000266041 | Inter-alpha-trypsin inhibitor heavy chain H4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration |
| SLIT1 protein network | https://string-db.org/network/9606.ENSP00000266058 | Slit homolog 1 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural develop [...] |
| SFRP5 protein network | https://string-db.org/network/9606.ENSP00000266066 | Secreted frizzled-related protein 5; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...] |
| GMEB2 protein network | https://string-db.org/network/9606.ENSP00000266068 | Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increas [...] |
| GID8 protein network | https://string-db.org/network/9606.ENSP00000266069 | Glucose-induced degradation protein 8 homolog; GID complex subunit 8 homolog |
| DIDO1 protein network | https://string-db.org/network/9606.ENSP00000266070 | Death-inducer obliterator 1; Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development; PHD fing [...] |
| SLC2A4RG protein network | https://string-db.org/network/9606.ENSP00000266077 | SLC2A4 regulator; Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3' |
| PRPF6 protein network | https://string-db.org/network/9606.ENSP00000266079 | Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced tr [...] |
| TIMP3 protein network | https://string-db.org/network/9606.ENSP00000266085 | Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-sp [...] |
| SLC5A4 protein network | https://string-db.org/network/9606.ENSP00000266086 | Solute carrier family 5 member 4; Has electrogenic activity in response to glucose, and may function as a glucose sensor. Mediates influx of sodium ions into the cell but does not transport sugar [...] |
| FBXO7 protein network | https://string-db.org/network/9606.ENSP00000266087 | F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradat [...] |
| SLC5A1 protein network | https://string-db.org/network/9606.ENSP00000266088 | Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is pro [...] |
| EIF2B2 protein network | https://string-db.org/network/9606.ENSP00000266126 | Translation initiation factor eIF-2B subunit beta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family |
| TTLL1 protein network | https://string-db.org/network/9606.ENSP00000266254 | Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carbo [...] |
| MTFP1 protein network | https://string-db.org/network/9606.ENSP00000266263 | Mitochondrial fission process protein 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function induces the release of cytochrome c, which activates the [...] |
| PATZ1 protein network | https://string-db.org/network/9606.ENSP00000266269 | POZ-, AT hook-, and zinc finger-containing protein 1; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TEF protein network | https://string-db.org/network/9606.ENSP00000266304 | Thyrotroph embryonic factor; Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'- [TC][AG][AG]TTA[TC][AG]-3'; Belongs to the bZIP f [...] |
| CACNA1C protein network | https://string-db.org/network/9606.ENSP00000266376 | Voltage-dependent L-type calcium channel subunit alpha-1C; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| B4GALNT3 protein network | https://string-db.org/network/9606.ENSP00000266383 | Beta-1,4-N-acetylgalactosaminyltransferase 3; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediami [...] |
| PDE6H protein network | https://string-db.org/network/9606.ENSP00000266395 | Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector mo [...] |
| ERP27 protein network | https://string-db.org/network/9606.ENSP00000266397 | Endoplasmic reticulum protein 27; Belongs to the protein disulfide isomerase family |
| GABARAPL1 protein network | https://string-db.org/network/9606.ENSP00000266458 | Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracell [...] |
| ALG10 protein network | https://string-db.org/network/9606.ENSP00000266483 | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose fr [...] |
| ARNTL2 protein network | https://string-db.org/network/9606.ENSP00000266503 | Aryl hydrocarbon receptor nuclear translocator-like protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system [...] |
| PLCZ1 protein network | https://string-db.org/network/9606.ENSP00000266505 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...] |
| ETNK1 protein network | https://string-db.org/network/9606.ENSP00000266517 | Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis |
| ZCRB1 protein network | https://string-db.org/network/9606.ENSP00000266529 | Zinc finger CCHC-type and RNA binding motif containing 1 |
| TMEM117 protein network | https://string-db.org/network/9606.ENSP00000266534 | Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway |
| C1RL protein network | https://string-db.org/network/9606.ENSP00000266542 | Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum; Belongs to the peptidase S1 family |
| NDUFA9 protein network | https://string-db.org/network/9606.ENSP00000266544 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...] |
| CLSTN3 protein network | https://string-db.org/network/9606.ENSP00000266546 | Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, [...] |
| TAPBPL protein network | https://string-db.org/network/9606.ENSP00000266556 | Tapasin-related protein; Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2- microglobulin/B2M. Association between TAPBPR and MHC class I [...] |
| CD27 protein network | https://string-db.org/network/9606.ENSP00000266557 | CD27 antigen; Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1 |
| RBP5 protein network | https://string-db.org/network/9606.ENSP00000266560 | Retinol-binding protein 5; Intracellular transport of retinol; Fatty acid binding protein family |
| AMIGO2 protein network | https://string-db.org/network/9606.ENSP00000266581 | Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIG [...] |
| ANP32D protein network | https://string-db.org/network/9606.ENSP00000266594 | Acidic nuclear phosphoprotein 32 family member D; Belongs to the ANP32 family |
| LLPH protein network | https://string-db.org/network/9606.ENSP00000266604 | Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission |
| MARCH9 protein network | https://string-db.org/network/9606.ENSP00000266643 | E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via mult [...] |
| INHBE protein network | https://string-db.org/network/9606.ENSP00000266646 | Inhibin beta E chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...] |
| GLIPR1 protein network | https://string-db.org/network/9606.ENSP00000266659 | Glioma pathogenesis-related protein 1; GLI pathogenesis related family 1 |
| PHLDA1 protein network | https://string-db.org/network/9606.ENSP00000266671 | Pleckstrin homology-like domain family A member 1; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neur [...] |
| TMEM19 protein network | https://string-db.org/network/9606.ENSP00000266673 | Transmembrane protein 19 |
| LGR5 protein network | https://string-db.org/network/9606.ENSP00000266674 | Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epitheli [...] |
| CPSF6 protein network | https://string-db.org/network/9606.ENSP00000266679 | Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/ [...] |
| SLC6A15 protein network | https://string-db.org/network/9606.ENSP00000266682 | Sodium-dependent neutral amino acid transporter B(0)AT2; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leuci [...] |
| TMTC3 protein network | https://string-db.org/network/9606.ENSP00000266712 | Transmembrane and TPR repeat-containing protein 3; Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response; [...] |
| LUM protein network | https://string-db.org/network/9606.ENSP00000266718 | Lumican; Small leucine rich repeat proteoglycans; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily |
| KERA protein network | https://string-db.org/network/9606.ENSP00000266719 | Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Small leucine rich repeat proteoglycans |
| TMPO protein network | https://string-db.org/network/9606.ENSP00000266732 | Lamina-associated polypeptide 2, isoform alpha; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA [...] |
| SNRPF protein network | https://string-db.org/network/9606.ENSP00000266735 | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an import [...] |
| AMDHD1 protein network | https://string-db.org/network/9606.ENSP00000266736 | Probable imidazolonepropionase; Amidohydrolase domain containing 1 |
| ASCL1 protein network | https://string-db.org/network/9606.ENSP00000266744 | Achaete-scute homolog 1; Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind [...] |
| SLC15A4 protein network | https://string-db.org/network/9606.ENSP00000266771 | Solute carrier family 15 member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides; Solute carriers |
| CDK2 protein network | https://string-db.org/network/9606.ENSP00000266970 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, N [...] |
| SLC39A5 protein network | https://string-db.org/network/9606.ENSP00000266980 | Zinc transporter ZIP5; May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic p [...] |
| TARBP2 protein network | https://string-db.org/network/9606.ENSP00000266987 | RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading c [...] |
| DHH protein network | https://string-db.org/network/9606.ENSP00000266991 | Desert hedgehog protein; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes d [...] |
| BIN2 protein network | https://string-db.org/network/9606.ENSP00000267012 | Bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulat [...] |
| NPFF protein network | https://string-db.org/network/9606.ENSP00000267017 | Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pre [...] |
| SMARCC2 protein network | https://string-db.org/network/9606.ENSP00000267064 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chroma [...] |
| ITGB7 protein network | https://string-db.org/network/9606.ENSP00000267082 | Integrin beta-7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (G [...] |
| CSAD protein network | https://string-db.org/network/9606.ENSP00000267085 | Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- s [...] |
| ERBB3 protein network | https://string-db.org/network/9606.ENSP00000267101 | Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand [...] |
| LMBR1L protein network | https://string-db.org/network/9606.ENSP00000267102 | Protein LMBR1L; Probable LCN1 receptor. May mediate LCN1 endocytosis |
| C12orf10 protein network | https://string-db.org/network/9606.ENSP00000267103 | UPF0160 protein MYG1, mitochondrial; Chromosome 12 open reading frame 10 |
| ESYT1 protein network | https://string-db.org/network/9606.ENSP00000267113 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates t [...] |
| ANKRD52 protein network | https://string-db.org/network/9606.ENSP00000267116 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...] |
| KRT71 protein network | https://string-db.org/network/9606.ENSP00000267119 | Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle |
| RB1 protein network | https://string-db.org/network/9606.ENSP00000267163 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcripti [...] |
| VPS33A protein network | https://string-db.org/network/9606.ENSP00000267199 | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. [...] |
| VPS37B protein network | https://string-db.org/network/9606.ENSP00000267202 | Vacuolar protein sorting-associated protein 37B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...] |
| RHOF protein network | https://string-db.org/network/9606.ENSP00000267205 | Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich su [...] |
| PXN protein network | https://string-db.org/network/9606.ENSP00000267257 | Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion); Belongs to the paxillin family |
| SRRM4 protein network | https://string-db.org/network/9606.ENSP00000267260 | Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjuction with nPTB/PTBP2 by binding directly to its regulated target [...] |
| METTL21C protein network | https://string-db.org/network/9606.ENSP00000267273 | Protein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase; Belongs to the methyltransferase superfamily. METTL21 family |
| MBNL2 protein network | https://string-db.org/network/9606.ENSP00000267287 | Muscleblind-like protein 2; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...] |
| RNF113B protein network | https://string-db.org/network/9606.ENSP00000267291 | Ring finger protein 113B |
| ZIC5 protein network | https://string-db.org/network/9606.ENSP00000267294 | Zinc finger protein ZIC 5; Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity); Zinc fingers C2H2-type |
| RAB20 protein network | https://string-db.org/network/9606.ENSP00000267328 | Ras-related protein Rab-20; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis [...] |
| ANKRD10 protein network | https://string-db.org/network/9606.ENSP00000267339 | Ankyrin repeat domain-containing protein 10; Ankyrin repeat domain containing |
| SSTR1 protein network | https://string-db.org/network/9606.ENSP00000267377 | Somatostatin receptor type 1; Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adeny [...] |
| REM2 protein network | https://string-db.org/network/9606.ENSP00000267396 | GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis; Belongs to the small GTPase superfamily. RGK family |
| CBLN3 protein network | https://string-db.org/network/9606.ENSP00000267406 | Cerebellin-3; May be involved in synaptic functions in the CNS |
| TINF2 protein network | https://string-db.org/network/9606.ENSP00000267415 | TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double- [...] |
| NOP9 protein network | https://string-db.org/network/9606.ENSP00000267425 | Nucleolar protein 9; Armadillo-like helical domain containing |
| FITM1 protein network | https://string-db.org/network/9606.ENSP00000267426 | Fat storage-inducing transmembrane protein 1; Plays an important role in lipid droplet accumulation; Belongs to the FIT family |
| FANCM protein network | https://string-db.org/network/9606.ENSP00000267430 | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the [...] |
| L2HGDH protein network | https://string-db.org/network/9606.ENSP00000267436 | L-2-hydroxyglutarate dehydrogenase, mitochondrial; L-2-hydroxyglutarate dehydrogenase; Belongs to the L2HGDH family |
| PELI2 protein network | https://string-db.org/network/9606.ENSP00000267460 | E3 ubiquitin-protein ligase pellino homolog 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathway [...] |
| RTN1 protein network | https://string-db.org/network/9606.ENSP00000267484 | Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells |
| C14orf37 protein network | https://string-db.org/network/9606.ENSP00000267485 | Uncharacterized protein C14orf37; Chromosome 14 open reading frame 37 |
| RAB15 protein network | https://string-db.org/network/9606.ENSP00000267512 | Ras-related protein Rab-15; RAB15, member RAS oncogene family |
| GPR65 protein network | https://string-db.org/network/9606.ENSP00000267549 | Psychosine receptor; Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and supporting ph [...] |
| JDP2 protein network | https://string-db.org/network/9606.ENSP00000267569 | Jun dimerization protein 2; Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses as [...] |
| AK7 protein network | https://string-db.org/network/9606.ENSP00000267584 | Adenylate kinase 7; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest a [...] |
| FAM181A protein network | https://string-db.org/network/9606.ENSP00000267594 | Protein FAM181A; Family with sequence similarity 181 member A |
| ITPK1 protein network | https://string-db.org/network/9606.ENSP00000267615 | Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1 [...] |
| TRIP11 protein network | https://string-db.org/network/9606.ENSP00000267622 | Thyroid receptor-interacting protein 11; Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB- modulated transcription. Golgi auto- [...] |
| EMC4 protein network | https://string-db.org/network/9606.ENSP00000267750 | ER membrane protein complex subunit 4; May mediate anti-apoptotic activity |
| DUOXA1 protein network | https://string-db.org/network/9606.ENSP00000267803 | Dual oxidase maturation factor 1; May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1 |
| ZNF280D protein network | https://string-db.org/network/9606.ENSP00000267807 | Zinc finger protein 280D; May function as a transcription factor |
| MFAP1 protein network | https://string-db.org/network/9606.ENSP00000267812 | Microfibrillar-associated protein 1; May be required for pre-mRNA splicing; Spliceosomal B complex |
| SORD protein network | https://string-db.org/network/9606.ENSP00000267814 | Sorbitol dehydrogenase; Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic [...] |
| LYSMD2 protein network | https://string-db.org/network/9606.ENSP00000267838 | LysM and putative peptidoglycan-binding domain-containing protein 2; LysM domain containing 2 |
| SLC27A2 protein network | https://string-db.org/network/9606.ENSP00000267842 | Very long-chain acyl-CoA synthetase; Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precursors of bile acids to their CoA thioesters derivatives before si [...] |
| FGF7 protein network | https://string-db.org/network/9606.ENSP00000267843 | Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth fa [...] |
| HDC protein network | https://string-db.org/network/9606.ENSP00000267845 | Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine; Belongs to the group II decarboxylase family |
| MYZAP protein network | https://string-db.org/network/9606.ENSP00000267853 | Myocardial zonula adherens protein; Plays a role in cellular signaling via Rho-related GTP- binding proteins and subsequent activation of transcription factor SRF (By similarity). Targets TJP1 to [...] |
| BNIP2 protein network | https://string-db.org/network/9606.ENSP00000267859 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins; BCH domain containing |
| SRP14 protein network | https://string-db.org/network/9606.ENSP00000267884 | Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with [...] |
| DISP2 protein network | https://string-db.org/network/9606.ENSP00000267889 | Dispatched RND transporter family member 2 |
| TTBK2 protein network | https://string-db.org/network/9606.ENSP00000267890 | Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting th [...] |
| COMMD4 protein network | https://string-db.org/network/9606.ENSP00000267935 | COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B |
| UBE2Q2 protein network | https://string-db.org/network/9606.ENSP00000267938 | Ubiquitin-conjugating enzyme E2 Q2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination; Ubiquiti [...] |
| BCL2A1 protein network | https://string-db.org/network/9606.ENSP00000267953 | Bcl-2-related protein A1; Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infec [...] |
| TSPAN3 protein network | https://string-db.org/network/9606.ENSP00000267970 | Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair; Belongs to the tetraspanin (TM4SF) family |
| WDR61 protein network | https://string-db.org/network/9606.ENSP00000267973 | WD repeat-containing protein 61; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and ma [...] |
| MESDC1 protein network | https://string-db.org/network/9606.ENSP00000267984 | Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells |
| IGF1R protein network | https://string-db.org/network/9606.ENSP00000268035 | Insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lowe [...] |
| ARRDC4 protein network | https://string-db.org/network/9606.ENSP00000268042 | Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein [...] |
| CYP11A1 protein network | https://string-db.org/network/9606.ENSP00000268053 | Cholesterol side-chain cleavage enzyme, mitochondrial; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone; Cytochrome P450 family 11 |
| BBS4 protein network | https://string-db.org/network/9606.ENSP00000268057 | Bardet-Biedl syndrome 4 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...] |
| PML protein network | https://string-db.org/network/9606.ENSP00000268058 | Protein PML; Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, s [...] |
| ADAMTS17 protein network | https://string-db.org/network/9606.ENSP00000268070 | ADAM metallopeptidase with thrombospondin type 1 motif 17 |
| HEXA protein network | https://string-db.org/network/9606.ENSP00000268097 | Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. [...] |
| SCAMP2 protein network | https://string-db.org/network/9606.ENSP00000268099 | Secretory carrier-associated membrane protein 2; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family |
| RHCG protein network | https://string-db.org/network/9606.ENSP00000268122 | Ammonium transporter Rh type C; Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion; Solute carriers |
| POLG protein network | https://string-db.org/network/9606.ENSP00000268124 | DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA; Belongs to the DNA polymerase type-A family |
| RLBP1 protein network | https://string-db.org/network/9606.ENSP00000268125 | Retinaldehyde-binding protein 1; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-r [...] |
| ABHD2 protein network | https://string-db.org/network/9606.ENSP00000268129 | Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone recepto [...] |
| WDR93 protein network | https://string-db.org/network/9606.ENSP00000268130 | WD repeat-containing protein 93; WD repeat domain containing |
| TICRR protein network | https://string-db.org/network/9606.ENSP00000268138 | Treslin; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loadin [...] |
| MFGE8 protein network | https://string-db.org/network/9606.ENSP00000268150 | Lactadherin; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Cont [...] |
| ZNF710 protein network | https://string-db.org/network/9606.ENSP00000268154 | Zinc finger protein 710; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ST8SIA2 protein network | https://string-db.org/network/9606.ENSP00000268164 | Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may [...] |
| IQGAP1 protein network | https://string-db.org/network/9606.ENSP00000268182 | Ras GTPase-activating-like protein IQGAP1; Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organiza [...] |
| CRTC3 protein network | https://string-db.org/network/9606.ENSP00000268184 | CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...] |
| EFTUD1 protein network | https://string-db.org/network/9606.ENSP00000268206 | Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 [...] |
| SEPT12 protein network | https://string-db.org/network/9606.ENSP00000268231 | Septin-12; Filament-forming cytoskeletal GTPase (By similarity). Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating t [...] |
| PMM2 protein network | https://string-db.org/network/9606.ENSP00000268261 | Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions; HAD Asp-based non-protein phosphat [...] |
| PRSS36 protein network | https://string-db.org/network/9606.ENSP00000268281 | Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln- Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a pre [...] |
| UQCRC2 protein network | https://string-db.org/network/9606.ENSP00000268379 | Cytochrome b-c1 complex subunit 2, mitochondrial; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial [...] |
| CDR2 protein network | https://string-db.org/network/9606.ENSP00000268383 | Cerebellar degeneration related protein 2 |
| IGSF6 protein network | https://string-db.org/network/9606.ENSP00000268389 | Immunoglobulin superfamily member 6; V-set domain containing |
| NKD1 protein network | https://string-db.org/network/9606.ENSP00000268459 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity; EF-hand domain [...] |
| DHX38 protein network | https://string-db.org/network/9606.ENSP00000268482 | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subf [...] |
| TXNL4B protein network | https://string-db.org/network/9606.ENSP00000268483 | Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family |
| ZFHX3 protein network | https://string-db.org/network/9606.ENSP00000268489 | Zinc finger homeobox protein 3; Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In c [...] |
| NUDT7 protein network | https://string-db.org/network/9606.ENSP00000268533 | Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the correspo [...] |
| CMTM2 protein network | https://string-db.org/network/9606.ENSP00000268595 | CKLF like MARVEL transmembrane domain containing 2; Belongs to the chemokine-like factor family |
| CDH11 protein network | https://string-db.org/network/9606.ENSP00000268603 | Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| MAP1LC3B protein network | https://string-db.org/network/9606.ENSP00000268607 | Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to reg [...] |
| CDH13 protein network | https://string-db.org/network/9606.ENSP00000268613 | Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| ZCCHC14 protein network | https://string-db.org/network/9606.ENSP00000268616 | Zinc finger CCHC domain-containing protein 14; Sterile alpha motif domain containing |
| ADAD2 protein network | https://string-db.org/network/9606.ENSP00000268624 | Adenosine deaminase domain containing 2; Adenosine deaminases acting on RNA |
| IRF8 protein network | https://string-db.org/network/9606.ENSP00000268638 | Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (t [...] |
| ZNF174 protein network | https://string-db.org/network/9606.ENSP00000268655 | Zinc finger protein 174; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| RPL3L protein network | https://string-db.org/network/9606.ENSP00000268661 | Ribosomal protein L3 like; Belongs to the universal ribosomal protein uL3 family |
| NDUFB10 protein network | https://string-db.org/network/9606.ENSP00000268668 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| DEF8 protein network | https://string-db.org/network/9606.ENSP00000268676 | Differentially expressed in FDCP 8 homolog; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption |
| CBFA2T3 protein network | https://string-db.org/network/9606.ENSP00000268679 | Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...] |
| GALNS protein network | https://string-db.org/network/9606.ENSP00000268695 | N-acetylgalactosamine-6-sulfatase; Galactosamine-6-sulfatase; Belongs to the sulfatase family |
| GAS8 protein network | https://string-db.org/network/9606.ENSP00000268699 | Growth arrest-specific protein 8; Cytoskeletal linker which binds microtubules and probably functions in axonemal and non-axonemal dynein regulation. May play a role in the spermatozoa motility ( [...] |
| SPG7 protein network | https://string-db.org/network/9606.ENSP00000268704 | Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable f [...] |
| MED9 protein network | https://string-db.org/network/9606.ENSP00000268711 | Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| NCOR1 protein network | https://string-db.org/network/9606.ENSP00000268712 | Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin [...] |
| COPS3 protein network | https://string-db.org/network/9606.ENSP00000268717 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| GID4 protein network | https://string-db.org/network/9606.ENSP00000268719 | Glucose-induced degradation protein 4 homolog; GID complex subunit 4 homolog; Belongs to the GID4/VID24 family |
| CPNE7 protein network | https://string-db.org/network/9606.ENSP00000268720 | Copine-7; Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family |
| NEK8 protein network | https://string-db.org/network/9606.ENSP00000268766 | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through ta [...] |
| DPEP3 protein network | https://string-db.org/network/9606.ENSP00000268793 | Dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 [...] |
| GFOD2 protein network | https://string-db.org/network/9606.ENSP00000268797 | Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly |
| NOB1 protein network | https://string-db.org/network/9606.ENSP00000268802 | RNA-binding protein NOB1; May play a role in mRNA degradation; Belongs to the NOB1 family |
| PRPSAP2 protein network | https://string-db.org/network/9606.ENSP00000268835 | Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis |
| UNC45B protein network | https://string-db.org/network/9606.ENSP00000268876 | Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is ne [...] |
| PCTP protein network | https://string-db.org/network/9606.ENSP00000268896 | Phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule; StAR related lipid transfer domain containing |
| KIF2B protein network | https://string-db.org/network/9606.ENSP00000268919 | Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. Plays a role in chromos [...] |
| EPN3 protein network | https://string-db.org/network/9606.ENSP00000268933 | Epsin-3; Epsin 3; Belongs to the epsin family |
| SGSM2 protein network | https://string-db.org/network/9606.ENSP00000268989 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosome [...] |
| LRRC46 protein network | https://string-db.org/network/9606.ENSP00000269025 | Leucine-rich repeat-containing protein 46; Leucine rich repeat containing 46 |
| RHBDL3 protein network | https://string-db.org/network/9606.ENSP00000269051 | Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 [...] |
| SPACA3 protein network | https://string-db.org/network/9606.ENSP00000269053 | Sperm acrosome membrane-associated protein 3; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential re [...] |
| ABCA10 protein network | https://string-db.org/network/9606.ENSP00000269081 | ATP-binding cassette sub-family A member 10; Probable transporter which may play a role in macrophage lipid homeostasis; ATP binding cassette subfamily A |
| G6PC3 protein network | https://string-db.org/network/9606.ENSP00000269097 | Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex [...] |
| C17orf64 protein network | https://string-db.org/network/9606.ENSP00000269127 | Uncharacterized protein C17orf64; Chromosome 17 open reading frame 64 |
| CDH2 protein network | https://string-db.org/network/9606.ENSP00000269141 | Cadherin-2; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| TAF4B protein network | https://string-db.org/network/9606.ENSP00000269142 | Transcription initiation factor TFIID subunit 4B; Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is [...] |
| AFG3L2 protein network | https://string-db.org/network/9606.ENSP00000269143 | AFG3-like protein 2; ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, li [...] |
| IMPA2 protein network | https://string-db.org/network/9606.ENSP00000269159 | Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the [...] |
| SLC39A6 protein network | https://string-db.org/network/9606.ENSP00000269187 | Zinc transporter ZIP6; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family |
| GALNT1 protein network | https://string-db.org/network/9606.ENSP00000269195 | Polypeptide N-acetylgalactosaminyltransferase 1; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| ASXL3 protein network | https://string-db.org/network/9606.ENSP00000269197 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive s [...] |
| MEP1B protein network | https://string-db.org/network/9606.ENSP00000269202 | Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, [...] |
| GAREM protein network | https://string-db.org/network/9606.ENSP00000269209 | GRB2-associated and regulator of MAPK protein 1; Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epiderm [...] |
| ESCO1 protein network | https://string-db.org/network/9606.ENSP00000269214 | N-acetyltransferase ESCO1; Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chroma [...] |
| GATA6 protein network | https://string-db.org/network/9606.ENSP00000269216 | Transcription factor GATA-6; Transcriptional activator. Regulates SEMA3C and PLXNA2. Involved in gene regulation specifically in the gastric epithelium. May regulate genes that protect epithelial [...] |
| C18orf8 protein network | https://string-db.org/network/9606.ENSP00000269221 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family |
| NPC1 protein network | https://string-db.org/network/9606.ENSP00000269228 | Niemann-Pick C1 protein; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. B [...] |
| ZMYND15 protein network | https://string-db.org/network/9606.ENSP00000269289 | Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May be important for spermiogenesis; Zinc fingers MYND-ty [...] |
| SAT2 protein network | https://string-db.org/network/9606.ENSP00000269298 | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine; GCN5 related N- [...] |
| ASGR1 protein network | https://string-db.org/network/9606.ENSP00000269299 | Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor rec [...] |
| TP53 protein network | https://string-db.org/network/9606.ENSP00000269305 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle r [...] |
| ARHGDIA protein network | https://string-db.org/network/9606.ENSP00000269321 | Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequen [...] |
| TTYH2 protein network | https://string-db.org/network/9606.ENSP00000269346 | Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation; [...] |
| EIF4A3 protein network | https://string-db.org/network/9606.ENSP00000269349 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC [...] |
| FN3KRP protein network | https://string-db.org/network/9606.ENSP00000269373 | Ketosamine-3-kinase; Phosphorylates psicosamines and ribulosamines, but not fructosamines, on the third carbon of the sugar moiety. Protein- bound psicosamine 3-phosphates and ribulosamine 3-phos [...] |
| TRIM65 protein network | https://string-db.org/network/9606.ENSP00000269383 | Tripartite motif containing 65; Belongs to the TRIM/RBCC family |
| CBX8 protein network | https://string-db.org/network/9606.ENSP00000269385 | Chromobox protein homolog 8; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| SECTM1 protein network | https://string-db.org/network/9606.ENSP00000269389 | Secreted and transmembrane protein 1; May be involved in thymocyte signaling |
| RNF157 protein network | https://string-db.org/network/9606.ENSP00000269391 | E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neu [...] |
| ZNF750 protein network | https://string-db.org/network/9606.ENSP00000269394 | Zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late [...] |
| CBX4 protein network | https://string-db.org/network/9606.ENSP00000269397 | E3 SUMO-protein ligase CBX4; E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly r [...] |
| RNF165 protein network | https://string-db.org/network/9606.ENSP00000269439 | E3 ubiquitin-protein ligase RNF165; E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing [...] |
| DYM protein network | https://string-db.org/network/9606.ENSP00000269445 | Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development; Belongs to the dymeclin family |
| ELAC1 protein network | https://string-db.org/network/9606.ENSP00000269466 | Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from p [...] |
| SERPINB12 protein network | https://string-db.org/network/9606.ENSP00000269491 | Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily |
| ZCCHC2 protein network | https://string-db.org/network/9606.ENSP00000269499 | Zinc finger CCHC-type containing 2 |
| CBLN2 protein network | https://string-db.org/network/9606.ENSP00000269503 | Cerebellin-2; May play role in synaptogenesis induction |
| ERBB2 protein network | https://string-db.org/network/9606.ENSP00000269571 | Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential comp [...] |
| KRT10 protein network | https://string-db.org/network/9606.ENSP00000269576 | Keratin, type I cytoskeletal 10; Keratins, type I |
| PNMT protein network | https://string-db.org/network/9606.ENSP00000269582 | Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family |
| ARL5C protein network | https://string-db.org/network/9606.ENSP00000269586 | Putative ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP; ARF GTPase family |
| IGFBP4 protein network | https://string-db.org/network/9606.ENSP00000269593 | Insulin-like growth factor-binding protein 4; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...] |
| TXNL4A protein network | https://string-db.org/network/9606.ENSP00000269601 | Thioredoxin-like protein 4A; Essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly; Belongs to the DIM1 famil [...] |
| AKAP8 protein network | https://string-db.org/network/9606.ENSP00000269701 | A-kinase anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mito [...] |
| CYP4F22 protein network | https://string-db.org/network/9606.ENSP00000269703 | Cytochrome P450 family 4 subfamily F member 22 |
| MIR1199 protein network | https://string-db.org/network/9606.ENSP00000269720 | Uncharacterized protein MISP3; microRNA 1199; Belongs to the MISP family |
| SLC39A3 protein network | https://string-db.org/network/9606.ENSP00000269740 | Zinc transporter ZIP3; Acts as a zinc-influx transporter; Solute carriers |
| ZNF544 protein network | https://string-db.org/network/9606.ENSP00000269829 | Zinc finger protein 544; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZIM3 protein network | https://string-db.org/network/9606.ENSP00000269834 | Zinc finger imprinted 3; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PRDM15 protein network | https://string-db.org/network/9606.ENSP00000269844 | PR domain zinc finger protein 15; May be involved in transcriptional regulation; PR/SET domain family |
| PFKL protein network | https://string-db.org/network/9606.ENSP00000269848 | ATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to t [...] |
| FEM1A protein network | https://string-db.org/network/9606.ENSP00000269856 | Protein fem-1 homolog A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit (By similarity). May participate in antiinflammatory [...] |
| CIB3 protein network | https://string-db.org/network/9606.ENSP00000269878 | Calcium and integrin binding family member 3; EF-hand domain containing |
| CALR3 protein network | https://string-db.org/network/9606.ENSP00000269881 | Calreticulin-3; During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility (By similarity). CALR3 capacity for calc [...] |
| SH3GL1 protein network | https://string-db.org/network/9606.ENSP00000269886 | Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity); Belongs to the endophilin family |
| PGPEP1 protein network | https://string-db.org/network/9606.ENSP00000269919 | Pyroglutamyl-peptidase 1; Removes 5-oxoproline from various penultimate amino acid residues except L-proline |
| DMRTC2 protein network | https://string-db.org/network/9606.ENSP00000269945 | Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family |
| CCDC97 protein network | https://string-db.org/network/9606.ENSP00000269967 | Coiled-coil domain containing 97 |
| ZNF45 protein network | https://string-db.org/network/9606.ENSP00000269973 | Zinc finger protein 45; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| BCKDHA protein network | https://string-db.org/network/9606.ENSP00000269980 | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It con [...] |
| ZFP14 protein network | https://string-db.org/network/9606.ENSP00000270001 | Zinc finger protein 14 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SSBP4 protein network | https://string-db.org/network/9606.ENSP00000270061 | Single stranded DNA binding protein 4 |
| SMG9 protein network | https://string-db.org/network/9606.ENSP00000270066 | Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SM [...] |
| PSG9 protein network | https://string-db.org/network/9606.ENSP00000270077 | Pregnancy specific beta-1-glycoprotein 9 |
| HUNK protein network | https://string-db.org/network/9606.ENSP00000270112 | Hormonally up-regulated Neu-associated kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily |
| LRRC56 protein network | https://string-db.org/network/9606.ENSP00000270115 | Leucine-rich repeat-containing protein 56; Leucine rich repeat containing 56 |
| IFNAR1 protein network | https://string-db.org/network/9606.ENSP00000270139 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interfero [...] |
| SOD1 protein network | https://string-db.org/network/9606.ENSP00000270142 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems |
| SIK1 protein network | https://string-db.org/network/9606.ENSP00000270162 | Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and di [...] |
| DNMT3L protein network | https://string-db.org/network/9606.ENSP00000270172 | DNA (cytosine-5)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By simil [...] |
| SCYL1 protein network | https://string-db.org/network/9606.ENSP00000270176 | N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the G [...] |
| EMP3 protein network | https://string-db.org/network/9606.ENSP00000270221 | Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions |
| DMWD protein network | https://string-db.org/network/9606.ENSP00000270223 | Dystrophia myotonica WD repeat-containing protein; DM1 locus, WD repeat containing |
| SAE1 protein network | https://string-db.org/network/9606.ENSP00000270225 | SUMO-activating enzyme subunit 1; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of [...] |
| BCAM protein network | https://string-db.org/network/9606.ENSP00000270233 | Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling; Blood group antigens |
| NTN5 protein network | https://string-db.org/network/9606.ENSP00000270235 | Plays a role in neurogenesis. Prevents motor neuron cell body migration out of the neural tube |
| LMTK3 protein network | https://string-db.org/network/9606.ENSP00000270238 | Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT- [...] |
| GEMIN7 protein network | https://string-db.org/network/9606.ENSP00000270257 | Gem-associated protein 7; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...] |
| CBLC protein network | https://string-db.org/network/9606.ENSP00000270279 | E3 ubiquitin-protein ligase CBL-C; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting th [...] |
| FXYD7 protein network | https://string-db.org/network/9606.ENSP00000270310 | FXYD domain containing ion transport regulator 7; Belongs to the FXYD family |
| ADAMTS10 protein network | https://string-db.org/network/9606.ENSP00000270328 | A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independen [...] |
| SLC6A3 protein network | https://string-db.org/network/9606.ENSP00000270349 | Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals; Solute carriers |
| RNPEPL1 protein network | https://string-db.org/network/9606.ENSP00000270357 | Aminopeptidase RNPEPL1; Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine; Belongs to the peptidase M1 family |
| CACNG8 protein network | https://string-db.org/network/9606.ENSP00000270458 | Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane a [...] |
| C19orf52 protein network | https://string-db.org/network/9606.ENSP00000270502 | Mitochondrial import inner membrane translocase subunit Tim29; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitoc [...] |
| ECSIT protein network | https://string-db.org/network/9606.ENSP00000270517 | Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa [...] |
| TIMM44 protein network | https://string-db.org/network/9606.ENSP00000270538 | Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inn [...] |
| TM4SF5 protein network | https://string-db.org/network/9606.ENSP00000270560 | Transmembrane 4 L six family member 5; Belongs to the L6 tetraspanin family |
| SLC47A1 protein network | https://string-db.org/network/9606.ENSP00000270570 | Multidrug and toxin extrusion protein 1; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanid [...] |
| KLHDC4 protein network | https://string-db.org/network/9606.ENSP00000270583 | Kelch domain containing 4 |
| PSMB6 protein network | https://string-db.org/network/9606.ENSP00000270586 | Proteasome subunit beta type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| GPR32 protein network | https://string-db.org/network/9606.ENSP00000270590 | Probable G-protein coupled receptor 32; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ACPT protein network | https://string-db.org/network/9606.ENSP00000270593 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis |
| RPS11 protein network | https://string-db.org/network/9606.ENSP00000270625 | Ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family |
| PTH2 protein network | https://string-db.org/network/9606.ENSP00000270631 | Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces prote [...] |
| IGLON5 protein network | https://string-db.org/network/9606.ENSP00000270642 | IgLON family member 5; Immunoglobulin like domain containing; IgLON cell adhesion molecules |
| RCN3 protein network | https://string-db.org/network/9606.ENSP00000270645 | Reticulocalbin-3; EF-hand domain containing; Belongs to the CREC family |
| ZNF614 protein network | https://string-db.org/network/9606.ENSP00000270649 | Zinc finger protein 614; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| WRAP73 protein network | https://string-db.org/network/9606.ENSP00000270708 | WD repeat-containing protein WRAP73; The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP [...] |
| PRDM16 protein network | https://string-db.org/network/9606.ENSP00000270722 | PR domain zinc finger protein 16; Binds DNA and functions as a transcriptional regulator. Functions in the differentiation of brown adipose tissue (BAT) which is specialized in dissipating chemic [...] |
| ARHGEF19 protein network | https://string-db.org/network/9606.ENSP00000270747 | Rho guanine nucleotide exchange factor 19; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase |
| PGD protein network | https://string-db.org/network/9606.ENSP00000270776 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH; B [...] |
| SH3BGRL3 protein network | https://string-db.org/network/9606.ENSP00000270792 | SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity |
| IL22RA1 protein network | https://string-db.org/network/9606.ENSP00000270800 | Interleukin-22 receptor subunit alpha-1; Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. [...] |
| EVA1B protein network | https://string-db.org/network/9606.ENSP00000270824 | Eva-1 homolog B; Belongs to the EVA1 family |
| PLK4 protein network | https://string-db.org/network/9606.ENSP00000270861 | Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental cen [...] |
| FCN3 protein network | https://string-db.org/network/9606.ENSP00000270879 | Ficolin-3; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/o [...] |
| TINAGL1 protein network | https://string-db.org/network/9606.ENSP00000271064 | Tubulointerstitial nephritis antigen-like; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non cat [...] |
| MOB3C protein network | https://string-db.org/network/9606.ENSP00000271139 | MOB kinase activator 3C; May regulate the activity of kinases; MOB kinase activators |
| SLC44A3 protein network | https://string-db.org/network/9606.ENSP00000271227 | Choline transporter-like protein 3; Solute carrier family 44 member 3 |
| FNBP1L protein network | https://string-db.org/network/9606.ENSP00000271234 | Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bis [...] |
| CTTNBP2NL protein network | https://string-db.org/network/9606.ENSP00000271277 | CTTNBP2 N-terminal-like protein; CTTNBP2 N-terminal like; STRIPAK complex |
| PSMA5 protein network | https://string-db.org/network/9606.ENSP00000271308 | Proteasome subunit alpha type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| CD53 protein network | https://string-db.org/network/9606.ENSP00000271324 | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By s [...] |
| PROK1 protein network | https://string-db.org/network/9606.ENSP00000271331 | Prokineticin-1; Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cell [...] |
| CELSR2 protein network | https://string-db.org/network/9606.ENSP00000271332 | Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. [...] |
| SFT2D2 protein network | https://string-db.org/network/9606.ENSP00000271375 | Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex |
| ILDR2 protein network | https://string-db.org/network/9606.ENSP00000271417 | Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways |
| FCGR2A protein network | https://string-db.org/network/9606.ENSP00000271450 | Low affinity immunoglobulin gamma Fc region receptor II-a; Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathog [...] |
| NUF2 protein network | https://string-db.org/network/9606.ENSP00000271452 | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for ki [...] |
| PRCC protein network | https://string-db.org/network/9606.ENSP00000271526 | Proline-rich protein PRCC; May regulate cell cycle progression through interaction with MAD2L2; Spliceosomal Bact complex |
| FCRL4 protein network | https://string-db.org/network/9606.ENSP00000271532 | Fc receptor-like protein 4; May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response; CD molecules |
| MEF2D protein network | https://string-db.org/network/9606.ENSP00000271555 | Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-ind [...] |
| HMCN1 protein network | https://string-db.org/network/9606.ENSP00000271588 | Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a [...] |
| PRUNE protein network | https://string-db.org/network/9606.ENSP00000271620 | Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a n [...] |
| SF3B4 protein network | https://string-db.org/network/9606.ENSP00000271628 | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| CGN protein network | https://string-db.org/network/9606.ENSP00000271636 | Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family |
| S100A11 protein network | https://string-db.org/network/9606.ENSP00000271638 | Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes; Belongs to the S-100 family |
| SETDB1 protein network | https://string-db.org/network/9606.ENSP00000271640 | Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic tran [...] |
| CTSK protein network | https://string-db.org/network/9606.ENSP00000271651 | Cathepsin K; Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH [...] |
| CERS2 protein network | https://string-db.org/network/9606.ENSP00000271688 | Ceramide synthase 2; Suppresses the growth of cancer cells. May be involved in sphingolipid synthesis; CERS class homeoboxes |
| POGZ protein network | https://string-db.org/network/9606.ENSP00000271715 | Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its assoc [...] |
| GOLPH3L protein network | https://string-db.org/network/9606.ENSP00000271732 | Golgi phosphoprotein 3-like; Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and antero [...] |
| KCNH1 protein network | https://string-db.org/network/9606.ENSP00000271751 | Potassium voltage-gated channel subfamily H member 1; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Me [...] |
| EIF2D protein network | https://string-db.org/network/9606.ENSP00000271764 | Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tR [...] |
| CRNN protein network | https://string-db.org/network/9606.ENSP00000271835 | Cornulin; Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calciu [...] |
| JTB protein network | https://string-db.org/network/9606.ENSP00000271843 | Protein JTB; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that ac [...] |
| CAPN9 protein network | https://string-db.org/network/9606.ENSP00000271971 | Calpain-9; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family |
| ACP1 protein network | https://string-db.org/network/9606.ENSP00000272067 | Low molecular weight phosphotyrosine protein phosphatase; Class II Cys-based phosphatases |
| SDE2 protein network | https://string-db.org/network/9606.ENSP00000272091 | Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monou [...] |
| CNIH3 protein network | https://string-db.org/network/9606.ENSP00000272133 | Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modula [...] |
| LEFTY1 protein network | https://string-db.org/network/9606.ENSP00000272134 | Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL |
| C1orf35 protein network | https://string-db.org/network/9606.ENSP00000272139 | Multiple myeloma tumor-associated protein 2; Chromosome 1 open reading frame 35 |
| WNT9A protein network | https://string-db.org/network/9606.ENSP00000272164 | Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| REN protein network | https://string-db.org/network/9606.ENSP00000272190 | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an eleva [...] |
| PPFIA4 protein network | https://string-db.org/network/9606.ENSP00000272198 | Liprin-alpha-4; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...] |
| PLEKHA6 protein network | https://string-db.org/network/9606.ENSP00000272203 | Pleckstrin homology domain containing A6 |
| ARL8A protein network | https://string-db.org/network/9606.ENSP00000272217 | ADP-ribosylation factor-like protein 8A; May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity); Belongs to the small GTPase superfamily. [...] |
| OSR1 protein network | https://string-db.org/network/9606.ENSP00000272223 | Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development; Zinc fingers C2H2-type |
| GDF7 protein network | https://string-db.org/network/9606.ENSP00000272224 | Growth/differentiation factor 7; May play an active role in the motor area of the primate neocortex |
| RHOB protein network | https://string-db.org/network/9606.ENSP00000272233 | Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling [...] |
| ATP6V1C2 protein network | https://string-db.org/network/9606.ENSP00000272238 | V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a sp [...] |
| GALM protein network | https://string-db.org/network/9606.ENSP00000272252 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) |
| ABCG8 protein network | https://string-db.org/network/9606.ENSP00000272286 | ATP-binding cassette sub-family G member 8; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role [...] |
| CALM2 protein network | https://string-db.org/network/9606.ENSP00000272298 | Calmodulin 2 (phosphorylase kinase, delta); EF-hand domain containing |
| RPS27A protein network | https://string-db.org/network/9606.ENSP00000272317 | Ubiquitin-40S ribosomal protein S27a; Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isop [...] |
| WDPCP protein network | https://string-db.org/network/9606.ENSP00000272321 | WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both cilio [...] |
| VPS54 protein network | https://string-db.org/network/9606.ENSP00000272322 | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The [...] |
| REG3G protein network | https://string-db.org/network/9606.ENSP00000272324 | Regenerating islet-derived protein 3-gamma; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydr [...] |
| ETAA1 protein network | https://string-db.org/network/9606.ENSP00000272342 | Ewing's tumor-associated antigen 1; Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replicat [...] |
| SNRPG protein network | https://string-db.org/network/9606.ENSP00000272348 | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an import [...] |
| CLEC4F protein network | https://string-db.org/network/9606.ENSP00000272367 | C-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis (By similarity); C-type lectin domain containing |
| MEIS1 protein network | https://string-db.org/network/9606.ENSP00000272369 | Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage dev [...] |
| OTOF protein network | https://string-db.org/network/9606.ENSP00000272371 | Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a [...] |
| TRIM43 protein network | https://string-db.org/network/9606.ENSP00000272395 | Tripartite motif containing 43; Ring finger proteins |
| MRPS5 protein network | https://string-db.org/network/9606.ENSP00000272418 | Belongs to the universal ribosomal protein uS5 family. |
| TPRKB protein network | https://string-db.org/network/9606.ENSP00000272424 | EKC/KEOPS complex subunit TPRKB; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...] |
| NAT8 protein network | https://string-db.org/network/9606.ENSP00000272425 | N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of r [...] |
| EXOC6B protein network | https://string-db.org/network/9606.ENSP00000272427 | Exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC15 family |
| RTKN protein network | https://string-db.org/network/9606.ENSP00000272430 | Rhotekin; Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin str [...] |
| SFXN5 protein network | https://string-db.org/network/9606.ENSP00000272433 | Sideroflexin-5; Transports citrate. Potential iron transporter (By similarity); Sideroflexins |
| TEX261 protein network | https://string-db.org/network/9606.ENSP00000272438 | Protein TEX261; Testis expressed 261 |
| DUSP11 protein network | https://string-db.org/network/9606.ENSP00000272444 | RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase ac [...] |
| SULT1C4 protein network | https://string-db.org/network/9606.ENSP00000272452 | Sulfotransferase 1C4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neu [...] |
| MALL protein network | https://string-db.org/network/9606.ENSP00000272462 | MAL-like protein; Mal, T cell differentiation protein like; Belongs to the MAL family |
| RALB protein network | https://string-db.org/network/9606.ENSP00000272519 | Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane [...] |
| C1QL2 protein network | https://string-db.org/network/9606.ENSP00000272520 | Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity); C1q and TNF related |
| SLC20A1 protein network | https://string-db.org/network/9606.ENSP00000272542 | Sodium-dependent phosphate transporter 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for no [...] |
| UBXN4 protein network | https://string-db.org/network/9606.ENSP00000272638 | UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD; UBX domain conta [...] |
| NXPH2 protein network | https://string-db.org/network/9606.ENSP00000272641 | Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family |
| THSD7B protein network | https://string-db.org/network/9606.ENSP00000272643 | Thrombospondin type-1 domain-containing protein 7B; Thrombospondin type 1 domain containing 7B |
| POLR2D protein network | https://string-db.org/network/9606.ENSP00000272645 | DNA-directed RNA polymerase II subunit RPB4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| AMMECR1L protein network | https://string-db.org/network/9606.ENSP00000272647 | AMMECR1-like protein; AMMECR1 like |
| SCRN3 protein network | https://string-db.org/network/9606.ENSP00000272732 | Secernin-3; Secernin 3 |
| KIAA1715 protein network | https://string-db.org/network/9606.ENSP00000272748 | Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nas [...] |
| TMEFF2 protein network | https://string-db.org/network/9606.ENSP00000272771 | Tomoregulin-2; May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation |
| PTH2R protein network | https://string-db.org/network/9606.ENSP00000272847 | Parathyroid hormone 2 receptor; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsi [...] |
| CPO protein network | https://string-db.org/network/9606.ENSP00000272852 | Carboxypeptidase O; Carboxypeptidase which preferentially cleaves C-terminal acidic residues from peptides and proteins. Can also cleave C- terminal hydrophobic amino acids, with a preference for [...] |
| ABCA12 protein network | https://string-db.org/network/9606.ENSP00000272895 | ATP-binding cassette sub-family A member 12; Probable transporter involved in lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family |
| SUMF1 protein network | https://string-db.org/network/9606.ENSP00000272902 | Sulfatase-modifying factor 1; Using molecular oxygen and an unidentified reducing agent, oxidizes a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is al [...] |
| NYAP2 protein network | https://string-db.org/network/9606.ENSP00000272907 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesi [...] |
| ACKR3 protein network | https://string-db.org/network/9606.ENSP00000272928 | Atypical chemokine receptor 3; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...] |
| HES6 protein network | https://string-db.org/network/9606.ENSP00000272937 | Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1- mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-m [...] |
| RAB5A protein network | https://string-db.org/network/9606.ENSP00000273047 | Ras-related protein Rab-5A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| CTDSP1 protein network | https://string-db.org/network/9606.ENSP00000273062 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domai [...] |
| SLC4A3 protein network | https://string-db.org/network/9606.ENSP00000273063 | Anion exchange protein 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transpo [...] |
| RQCD1 protein network | https://string-db.org/network/9606.ENSP00000273064 | CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...] |
| MARCH4 protein network | https://string-db.org/network/9606.ENSP00000273067 | E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicu [...] |
| DNPEP protein network | https://string-db.org/network/9606.ENSP00000273075 | Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism |
| PNKD protein network | https://string-db.org/network/9606.ENSP00000273077 | Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa- B signaling pathway; Belongs to the metallo-be [...] |
| DYNC1LI1 protein network | https://string-db.org/network/9606.ENSP00000273130 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to [...] |
| CSRNP1 protein network | https://string-db.org/network/9606.ENSP00000273153 | Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity (By similarity). May have a tumor-suppressor function. May play a r [...] |
| SLC25A38 protein network | https://string-db.org/network/9606.ENSP00000273158 | Solute carrier family 25 member 38; Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) productio [...] |
| SLC22A14 protein network | https://string-db.org/network/9606.ENSP00000273173 | Solute carrier family 22 member 14; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
| CTDSPL protein network | https://string-db.org/network/9606.ENSP00000273179 | CTD small phosphatase-like protein; Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially cataly [...] |
| STAC protein network | https://string-db.org/network/9606.ENSP00000273183 | SH3 and cysteine-rich domain-containing protein; Probably involved in a neuron-specific signal transduction |
| ARL6IP5 protein network | https://string-db.org/network/9606.ENSP00000273258 | PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in [...] |
| LRIG1 protein network | https://string-db.org/network/9606.ENSP00000273261 | Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of r [...] |
| ITIH1 protein network | https://string-db.org/network/9606.ENSP00000273283 | Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...] |
| LRTM1 protein network | https://string-db.org/network/9606.ENSP00000273286 | Leucine rich repeats and transmembrane domains 1 |
| CNPY2 protein network | https://string-db.org/network/9606.ENSP00000273308 | Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal [...] |
| LIMD1 protein network | https://string-db.org/network/9606.ENSP00000273317 | LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate deter [...] |
| ZKSCAN7 protein network | https://string-db.org/network/9606.ENSP00000273320 | Zinc finger protein with KRAB and SCAN domains 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| GPR128 protein network | https://string-db.org/network/9606.ENSP00000273352 | Adhesion G-protein coupled receptor G7; Orphan receptor |
| MYH15 protein network | https://string-db.org/network/9606.ENSP00000273353 | Myosin-15; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family |
| ABHD10 protein network | https://string-db.org/network/9606.ENSP00000273359 | Mycophenolic acid acyl-glucuronide esterase, mitochondrial; Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate; Belong [...] |
| PLA1A protein network | https://string-db.org/network/9606.ENSP00000273371 | Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposome [...] |
| RABL3 protein network | https://string-db.org/network/9606.ENSP00000273375 | Rab-like protein 3; RAB, member of RAS oncogene family like 3; Belongs to the small GTPase superfamily. Rab family |
| MAATS1 protein network | https://string-db.org/network/9606.ENSP00000273390 | Cilia- and flagella-associated protein 91; May regulate cilium motility through its role in the assembly of the axonemal radial spokes |
| ATP6V1A protein network | https://string-db.org/network/9606.ENSP00000273398 | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular comp [...] |
| ALDH1L1 protein network | https://string-db.org/network/9606.ENSP00000273450 | Cytosolic 10-formyltetrahydrofolate dehydrogenase; Aldehyde dehydrogenase 1 family member L1; In the N-terminal section; belongs to the GART family |
| RNF7 protein network | https://string-db.org/network/9606.ENSP00000273480 | RING-box protein 2; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins [...] |
| ISY1 protein network | https://string-db.org/network/9606.ENSP00000273541 | Pre-mRNA-splicing factor ISY1 homolog; May play a role in pre-mRNA splicing; Spliceosomal B complex |
| FTH1 protein network | https://string-db.org/network/9606.ENSP00000273550 | Ferritin heavy chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as [...] |
| AMT protein network | https://string-db.org/network/9606.ENSP00000273588 | Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine |
| TCTA protein network | https://string-db.org/network/9606.ENSP00000273590 | T-cell leukemia translocation-altered gene protein; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family |
| ABHD14A protein network | https://string-db.org/network/9606.ENSP00000273596 | Protein ABHD14A; Possible role in granule neuron development; Abhydrolase domain containing |
| NICN1 protein network | https://string-db.org/network/9606.ENSP00000273598 | Nicolin-1; Nicolin 1 |
| UCN2 protein network | https://string-db.org/network/9606.ENSP00000273610 | Urocortin-2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress; Belongs to the sauvag [...] |
| STXBP5L protein network | https://string-db.org/network/9606.ENSP00000273666 | Syntaxin-binding protein 5-like; May play a role in vesicle trafficking and exocytosis; Belongs to the WD repeat L(2)GL family |
| EAF2 protein network | https://string-db.org/network/9606.ENSP00000273668 | ELL-associated factor 2; Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity). Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Pot [...] |
| TM4SF19 protein network | https://string-db.org/network/9606.ENSP00000273695 | Transmembrane 4 L six family member 19; Belongs to the L6 tetraspanin family |
| EIF2B5 protein network | https://string-db.org/network/9606.ENSP00000273783 | Translation initiation factor eIF-2B subunit epsilon; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family |
| DGKQ protein network | https://string-db.org/network/9606.ENSP00000273814 | Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two sig [...] |
| CENPC protein network | https://string-db.org/network/9606.ENSP00000273853 | Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| CORIN protein network | https://string-db.org/network/9606.ENSP00000273857 | Atrial natriuretic peptide-converting enzyme; Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional [...] |
| ATP10D protein network | https://string-db.org/network/9606.ENSP00000273859 | Probable phospholipid-transporting ATPase VD; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...] |
| SLC10A4 protein network | https://string-db.org/network/9606.ENSP00000273861 | Sodium/bile acid cotransporter 4; Transporter for bile acids; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family |
| SLC10A6 protein network | https://string-db.org/network/9606.ENSP00000273905 | Solute carrier family 10 member 6; Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner; Belongs to the [...] |
| ENOPH1 protein network | https://string-db.org/network/9606.ENSP00000273920 | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1- [...] |
| CABS1 protein network | https://string-db.org/network/9606.ENSP00000273936 | Calcium-binding and spermatid-specific protein 1; Calcium binding protein, spermatid associated 1 |
| TRMT10A protein network | https://string-db.org/network/9606.ENSP00000273962 | tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs. Probably [...] |
| KLHL8 protein network | https://string-db.org/network/9606.ENSP00000273963 | Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation [...] |
| PYURF protein network | https://string-db.org/network/9606.ENSP00000273968 | Protein preY, mitochondrial; PIGY upstream reading frame; Belongs to the PREY family |
| TBCK protein network | https://string-db.org/network/9606.ENSP00000273980 | TBC domain-containing protein kinase-like protein; Involved in the modulation of mTOR signaling and expression of mTOR complex components. Involved in the regulation of cell proliferation and gro [...] |
| CISD2 protein network | https://string-db.org/network/9606.ENSP00000273986 | CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interactio [...] |
| AP1AR protein network | https://string-db.org/network/9606.ENSP00000274000 | AP-1 complex-associated regulatory protein; Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of [...] |
| SPATA5 protein network | https://string-db.org/network/9606.ENSP00000274008 | Spermatogenesis-associated protein 5; May be involved in morphological and functional mitochondrial transformations during spermatogenesis; Belongs to the AAA ATPase family. AFG2 subfamily |
| FABP2 protein network | https://string-db.org/network/9606.ENSP00000274024 | Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglycer [...] |
| CCNA2 protein network | https://string-db.org/network/9606.ENSP00000274026 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes w [...] |
| SETD7 protein network | https://string-db.org/network/9606.ENSP00000274031 | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcr [...] |
| NAF1 protein network | https://string-db.org/network/9606.ENSP00000274054 | H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs c [...] |
| SFRP2 protein network | https://string-db.org/network/9606.ENSP00000274063 | Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...] |
| GLRA3 protein network | https://string-db.org/network/9606.ENSP00000274093 | Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit compos [...] |
| NDUFS6 protein network | https://string-db.org/network/9606.ENSP00000274137 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be [...] |
| MARCH6 protein network | https://string-db.org/network/9606.ENSP00000274140 | E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjug [...] |
| ADAMTS16 protein network | https://string-db.org/network/9606.ENSP00000274181 | ADAM metallopeptidase with thrombospondin type 1 motif 16 |
| SRD5A1 protein network | https://string-db.org/network/9606.ENSP00000274192 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a cent [...] |
| FAM105A protein network | https://string-db.org/network/9606.ENSP00000274217 | Inactive ubiquitin thioesterase FAM105A; Family with sequence similarity 105 member A; Belongs to the peptidase C65 family. Otulin subfamily |
| RPL37 protein network | https://string-db.org/network/9606.ENSP00000274242 | 60S ribosomal protein L37; Binds to the 23S rRNA; L ribosomal proteins |
| SKP2 protein network | https://string-db.org/network/9606.ENSP00000274255 | S-phase kinase-associated protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent prote [...] |
| OSMR protein network | https://string-db.org/network/9606.ENSP00000274276 | Oncostatin-M-specific receptor subunit beta; Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signa [...] |
| UGT3A1 protein network | https://string-db.org/network/9606.ENSP00000274278 | UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...] |
| PLK2 protein network | https://string-db.org/network/9606.ENSP00000274289 | Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by b [...] |
| GZMA protein network | https://string-db.org/network/9606.ENSP00000274306 | Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered in [...] |
| PELO protein network | https://string-db.org/network/9606.ENSP00000274311 | Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability (By similarity). May function in recognizing stalled ribosomes and triggering endonuc [...] |
| HAPLN1 protein network | https://string-db.org/network/9606.ENSP00000274341 | Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix; V-set domain containing |
| BHMT protein network | https://string-db.org/network/9606.ENSP00000274353 | Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reactio [...] |
| ANKRD31 protein network | https://string-db.org/network/9606.ENSP00000274361 | Putative ankyrin repeat domain-containing protein 31; Ankyrin repeat domain containing |
| IQGAP2 protein network | https://string-db.org/network/9606.ENSP00000274364 | Ras GTPase-activating-like protein IQGAP2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin |
| CRHBP protein network | https://string-db.org/network/9606.ENSP00000274368 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy |
| RASA1 protein network | https://string-db.org/network/9606.ENSP00000274376 | Ras GTPase-activating protein 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the pr [...] |
| LIX1 protein network | https://string-db.org/network/9606.ENSP00000274382 | Protein limb expression 1 homolog; Limb and CNS expressed 1; Belongs to the LIX1 family |
| SPATA9 protein network | https://string-db.org/network/9606.ENSP00000274432 | Spermatogenesis-associated protein 9; May play a role in testicular development/spermatogenesis and may be an important factor in male infertility |
| FEM1C protein network | https://string-db.org/network/9606.ENSP00000274457 | Protein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family |
| COMMD10 protein network | https://string-db.org/network/9606.ENSP00000274458 | COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B |
| MEGF10 protein network | https://string-db.org/network/9606.ENSP00000274473 | Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that bin [...] |
| ADAMTS19 protein network | https://string-db.org/network/9606.ENSP00000274487 | ADAM metallopeptidase with thrombospondin type 1 motif 19 |
| YIPF5 protein network | https://string-db.org/network/9606.ENSP00000274496 | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing |
| ARHGAP26 protein network | https://string-db.org/network/9606.ENSP00000274498 | Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42 |
| LECT2 protein network | https://string-db.org/network/9606.ENSP00000274507 | Leukocyte cell-derived chemotaxin-2; Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation. Does not show metalloendopeptidase activity; Belongs to the LEC [...] |
| IL9 protein network | https://string-db.org/network/9606.ENSP00000274520 | Interleukin-9; Supports IL-2 independent and IL-4 independent growth of helper T-cells; Interleukins |
| TIMD4 protein network | https://string-db.org/network/9606.ENSP00000274532 | T-cell immunoglobulin and mucin domain-containing protein 4; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotox [...] |
| GABRA6 protein network | https://string-db.org/network/9606.ENSP00000274545 | Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| GABRB2 protein network | https://string-db.org/network/9606.ENSP00000274547 | Gamma-aminobutyric acid receptor subunit beta-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine re [...] |
| SPINK7 protein network | https://string-db.org/network/9606.ENSP00000274565 | Serine protease inhibitor Kazal-type 7; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type |
| PCYOX1L protein network | https://string-db.org/network/9606.ENSP00000274569 | Prenylcysteine oxidase-like; Probable oxidoreductase; Belongs to the prenylcysteine oxidase family |
| N4BP3 protein network | https://string-db.org/network/9606.ENSP00000274605 | NEDD4-binding protein 3; Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior [...] |
| NHP2 protein network | https://string-db.org/network/9606.ENSP00000274606 | H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...] |
| FGF18 protein network | https://string-db.org/network/9606.ENSP00000274625 | Fibroblast growth factor 18; Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimu [...] |
| KCNMB1 protein network | https://string-db.org/network/9606.ENSP00000274629 | Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...] |
| MYLK4 protein network | https://string-db.org/network/9606.ENSP00000274643 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family |
| FAM217A protein network | https://string-db.org/network/9606.ENSP00000274673 | Protein FAM217A; Family with sequence similarity 217 member A; Belongs to the FAM217 family |
| CDKAL1 protein network | https://string-db.org/network/9606.ENSP00000274695 | Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladen [...] |
| PSD2 protein network | https://string-db.org/network/9606.ENSP00000274710 | Pleckstrin and Sec7 domain containing 2 |
| LRRTM2 protein network | https://string-db.org/network/9606.ENSP00000274711 | Leucine-rich repeat transmembrane neuronal protein 2; Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA rece [...] |
| ZMAT2 protein network | https://string-db.org/network/9606.ENSP00000274712 | Zinc finger matrin-type 2; Spliceosomal B complex |
| GFRA3 protein network | https://string-db.org/network/9606.ENSP00000274721 | GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyr [...] |
| HIST1H2BA protein network | https://string-db.org/network/9606.ENSP00000274764 | Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical h [...] |
| KAAG1 protein network | https://string-db.org/network/9606.ENSP00000274766 | Kidney associated antigen 1 |
| TRIM7 protein network | https://string-db.org/network/9606.ENSP00000274773 | E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling [...] |
| HIGD2A protein network | https://string-db.org/network/9606.ENSP00000274787 | HIG1 domain family member 2A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the [...] |
| PLA2G7 protein network | https://string-db.org/network/9606.ENSP00000274793 | Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specific [...] |
| RNF44 protein network | https://string-db.org/network/9606.ENSP00000274811 | Ring finger protein 44 |
| MUT protein network | https://string-db.org/network/9606.ENSP00000274813 | Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has diff [...] |
| ABT1 protein network | https://string-db.org/network/9606.ENSP00000274849 | Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II g [...] |
| PPP1R18 protein network | https://string-db.org/network/9606.ENSP00000274853 | Phostensin; Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton |
| SCUBE3 protein network | https://string-db.org/network/9606.ENSP00000274938 | Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TG [...] |
| FGD2 protein network | https://string-db.org/network/9606.ENSP00000274963 | FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not [...] |
| ANO7 protein network | https://string-db.org/network/9606.ENSP00000274979 | Anoctamin-7; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated [...] |
| NFKBIE protein network | https://string-db.org/network/9606.ENSP00000275015 | NF-kappa-B inhibitor epsilon; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes |
| CYP39A1 protein network | https://string-db.org/network/9606.ENSP00000275016 | 24-hydroxycholesterol 7-alpha-hydroxylase; Involved in the bile acid metabolism. Has a preference for 24-hydroxycholesterol, and converts it into a 7-alpha- hydroxylated product; Cytochrome P450 [...] |
| PHIP protein network | https://string-db.org/network/9606.ENSP00000275034 | PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an an [...] |
| MMS22L protein network | https://string-db.org/network/9606.ENSP00000275053 | Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is requ [...] |
| PM20D2 protein network | https://string-db.org/network/9606.ENSP00000275072 | Peptidase M20 domain containing 2 |
| CLVS2 protein network | https://string-db.org/network/9606.ENSP00000275162 | Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) |
| TAAR6 protein network | https://string-db.org/network/9606.ENSP00000275198 | Trace amine-associated receptor 6; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...] |
| TAAR8 protein network | https://string-db.org/network/9606.ENSP00000275200 | Trace amine-associated receptor 8; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...] |
| TAAR1 protein network | https://string-db.org/network/9606.ENSP00000275216 | Trace amine-associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. U [...] |
| SLC18B1 protein network | https://string-db.org/network/9606.ENSP00000275227 | MFS-type transporter SLC18B1; Solute carrier family 18 member B1 |
| SLC2A12 protein network | https://string-db.org/network/9606.ENSP00000275230 | Solute carrier family 2, facilitated glucose transporter member 12; Facilitative glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose [...] |
| SLC22A3 protein network | https://string-db.org/network/9606.ENSP00000275300 | Solute carrier family 22 member 3; Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmit [...] |
| VWDE protein network | https://string-db.org/network/9606.ENSP00000275358 | Von Willebrand factor D and EGF domains |
| GNA12 protein network | https://string-db.org/network/9606.ENSP00000275364 | Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activat [...] |
| GGCT protein network | https://string-db.org/network/9606.ENSP00000275428 | Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c [...] |
| FERD3L protein network | https://string-db.org/network/9606.ENSP00000275461 | Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation [...] |
| EGFR protein network | https://string-db.org/network/9606.ENSP00000275493 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular resp [...] |
| CDCA5 protein network | https://string-db.org/network/9606.ENSP00000275517 | Sororin; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chr [...] |
| IGFBP1 protein network | https://string-db.org/network/9606.ENSP00000275525 | Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...] |
| KCTD7 protein network | https://string-db.org/network/9606.ENSP00000275532 | BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons |
| SSC4D protein network | https://string-db.org/network/9606.ENSP00000275560 | Scavenger receptor cysteine-rich domain-containing group B protein; Scavenger receptor cysteine rich family member with 4 domains |
| CCT6A protein network | https://string-db.org/network/9606.ENSP00000275603 | T-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP [...] |
| SLC12A9 protein network | https://string-db.org/network/9606.ENSP00000275730 | Solute carrier family 12 member 9; May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function [...] |
| GIGYF1 protein network | https://string-db.org/network/9606.ENSP00000275732 | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phos [...] |
| STRA8 protein network | https://string-db.org/network/9606.ENSP00000275764 | Stimulated by retinoic acid gene 8 protein homolog; Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA [...] |
| ZC3HAV1L protein network | https://string-db.org/network/9606.ENSP00000275766 | Zinc finger CCCH-type containing, antiviral 1 like |
| TMEM140 protein network | https://string-db.org/network/9606.ENSP00000275767 | Transmembrane protein 140 |
| EPHA1 protein network | https://string-db.org/network/9606.ENSP00000275815 | Ephrin type-A receptor 1; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalin [...] |
| NOM1 protein network | https://string-db.org/network/9606.ENSP00000275820 | Nucleolar MIF4G domain-containing protein 1; Plays a role in targeting PPP1CA to the nucleolus; Protein phosphatase 1 regulatory subunits |
| DENND2A protein network | https://string-db.org/network/9606.ENSP00000275884 | DENN domain-containing protein 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...] |
| TMEM47 protein network | https://string-db.org/network/9606.ENSP00000275954 | Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polym [...] |
| CDK16 protein network | https://string-db.org/network/9606.ENSP00000276052 | Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regula [...] |
| CHST7 protein network | https://string-db.org/network/9606.ENSP00000276055 | Carbohydrate sulfotransferase 7; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...] |
| NDUFB11 protein network | https://string-db.org/network/9606.ENSP00000276062 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...] |
| RAB41 protein network | https://string-db.org/network/9606.ENSP00000276066 | Ras-related protein Rab-41; Required for normal Golgi ribbon organization and ER-to- Golgi trafficking; RAB, member RAS oncogene GTPases |
| GPR174 protein network | https://string-db.org/network/9606.ENSP00000276077 | Probable G-protein coupled receptor 174; Putative receptor for purines coupled to G-proteins; G protein-coupled receptors, Class A orphans |
| NONO protein network | https://string-db.org/network/9606.ENSP00000276079 | Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds [...] |
| CPXCR1 protein network | https://string-db.org/network/9606.ENSP00000276127 | CPX chromosome region, candidate 1 |
| RIPPLY1 protein network | https://string-db.org/network/9606.ENSP00000276173 | Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, a [...] |
| FRMPD3 protein network | https://string-db.org/network/9606.ENSP00000276185 | FERM and PDZ domain containing 3 |
| HTR2C protein network | https://string-db.org/network/9606.ENSP00000276198 | 5-hydroxytryptamine receptor 2C; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkalo [...] |
| UPF3B protein network | https://string-db.org/network/9606.ENSP00000276201 | Regulator of nonsense transcripts 3B; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving a [...] |
| DOCK11 protein network | https://string-db.org/network/9606.ENSP00000276202 | Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is ass [...] |
| ARHGAP36 protein network | https://string-db.org/network/9606.ENSP00000276211 | Rho GTPase-activating protein 36; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state |
| GPR119 protein network | https://string-db.org/network/9606.ENSP00000276218 | Glucose-dependent insulinotropic receptor; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulin [...] |
| CT55 protein network | https://string-db.org/network/9606.ENSP00000276241 | Cancer/testis antigen 55 |
| MFHAS1 protein network | https://string-db.org/network/9606.ENSP00000276282 | Malignant fibrous histiocytoma amplified sequence 1; Roco domain containing |
| DLC1 protein network | https://string-db.org/network/9606.ENSP00000276297 | Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological chan [...] |
| ATP6V1B2 protein network | https://string-db.org/network/9606.ENSP00000276390 | V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartment [...] |
| CHRNA6 protein network | https://string-db.org/network/9606.ENSP00000276410 | Neuronal acetylcholine receptor subunit alpha-6; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| GNRH1 protein network | https://string-db.org/network/9606.ENSP00000276414 | Progonadoliberin-1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Endogenous ligands |
| BIN3 protein network | https://string-db.org/network/9606.ENSP00000276416 | Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin; N-BAR domain containing |
| DOK2 protein network | https://string-db.org/network/9606.ENSP00000276420 | Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate [...] |
| TNFRSF10B protein network | https://string-db.org/network/9606.ENSP00000276431 | Tumor necrosis factor receptor superfamily member 10B; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death [...] |
| DOCK5 protein network | https://string-db.org/network/9606.ENSP00000276440 | Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with [...] |
| STAR protein network | https://string-db.org/network/9606.ENSP00000276449 | Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholest [...] |
| ERLIN2 protein network | https://string-db.org/network/9606.ENSP00000276461 | Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes st [...] |
| ST18 protein network | https://string-db.org/network/9606.ENSP00000276480 | Suppression of tumorigenicity 18 protein; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleot [...] |
| GINS4 protein network | https://string-db.org/network/9606.ENSP00000276533 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS com [...] |
| ARMC1 protein network | https://string-db.org/network/9606.ENSP00000276569 | Armadillo repeat containing 1 |
| DNAJC5B protein network | https://string-db.org/network/9606.ENSP00000276570 | DnaJ heat shock protein family member C5 beta |
| CRH protein network | https://string-db.org/network/9606.ENSP00000276571 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By [...] |
| MRPS28 protein network | https://string-db.org/network/9606.ENSP00000276585 | Mitochondrial ribosomal protein S28; Belongs to the bacterial ribosomal protein bS1 family |
| LACTB2 protein network | https://string-db.org/network/9606.ENSP00000276590 | Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no ac [...] |
| PRDM14 protein network | https://string-db.org/network/9606.ENSP00000276594 | PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisitio [...] |
| TERF1 protein network | https://string-db.org/network/9606.ENSP00000276603 | Telomeric repeat-binding factor 1; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component o [...] |
| PSKH2 protein network | https://string-db.org/network/9606.ENSP00000276616 | Protein serine kinase H2 |
| DPYS protein network | https://string-db.org/network/9606.ENSP00000276651 | Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6- dihydro [...] |
| LRP12 protein network | https://string-db.org/network/9606.ENSP00000276654 | Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppres [...] |
| RSPO2 protein network | https://string-db.org/network/9606.ENSP00000276659 | R-spondin-2; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...] |
| NDUFB9 protein network | https://string-db.org/network/9606.ENSP00000276689 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved [...] |
| TATDN1 protein network | https://string-db.org/network/9606.ENSP00000276692 | Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family |
| C8orf76 protein network | https://string-db.org/network/9606.ENSP00000276704 | Uncharacterized protein C8orf76; Chromosome 8 open reading frame 76 |
| GSDMC protein network | https://string-db.org/network/9606.ENSP00000276708 | Gasdermin-C; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Proba [...] |
| ZNF16 protein network | https://string-db.org/network/9606.ENSP00000276816 | Zinc finger protein 16; Acts as a transcriptional activator. Promotes cell proliferation by facilitating the cell cycle phase transition from the S to G2/M phase. Involved in both the hemin- and [...] |
| UHRF2 protein network | https://string-db.org/network/9606.ENSP00000276893 | E3 ubiquitin-protein ligase UHRF2; E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a ti [...] |
| PLIN2 protein network | https://string-db.org/network/9606.ENSP00000276914 | Perilipin-2; May be involved in development and maintenance of adipose tissue; Perilipins |
| CDKN2B protein network | https://string-db.org/network/9606.ENSP00000276925 | Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest; Belongs to the CDKN2 cyclin-dependent kin [...] |
| IFNA1 protein network | https://string-db.org/network/9606.ENSP00000276927 | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belong [...] |
| IFNK protein network | https://string-db.org/network/9606.ENSP00000276943 | Interferon kappa; May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interfer [...] |
| SIGMAR1 protein network | https://string-db.org/network/9606.ENSP00000277010 | Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the bio [...] |
| NTRK2 protein network | https://string-db.org/network/9606.ENSP00000277120 | BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, [...] |
| FAM120A protein network | https://string-db.org/network/9606.ENSP00000277165 | Constitutive coactivator of PPAR-gamma-like protein 1; May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. A [...] |
| OR13C4 protein network | https://string-db.org/network/9606.ENSP00000277216 | Olfactory receptor 13C4; Odorant receptor; Olfactory receptors, family 13 |
| ZNF462 protein network | https://string-db.org/network/9606.ENSP00000277225 | Zinc finger protein 462; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR1K1 protein network | https://string-db.org/network/9606.ENSP00000277309 | Olfactory receptor 1K1; Odorant receptor; Olfactory receptors, family 1 |
| ASB6 protein network | https://string-db.org/network/9606.ENSP00000277458 | Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...] |
| IDI2 protein network | https://string-db.org/network/9606.ENSP00000277517 | Isopentenyl-diphosphate delta-isomerase 2; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosp [...] |
| LCN9 protein network | https://string-db.org/network/9606.ENSP00000277526 | Epididymal-specific lipocalin-9; Lipocalin 9; Lipocalins |
| DPH7 protein network | https://string-db.org/network/9606.ENSP00000277540 | Diphthine methyltransferase; Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine whi [...] |
| NOTCH1 protein network | https://string-db.org/network/9606.ENSP00000277541 | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...] |
| NACC2 protein network | https://string-db.org/network/9606.ENSP00000277554 | Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the r [...] |
| PROSER2 protein network | https://string-db.org/network/9606.ENSP00000277570 | Proline and serine rich 2 |
| USP6NL protein network | https://string-db.org/network/9606.ENSP00000277575 | USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrogr [...] |
| FAM188A protein network | https://string-db.org/network/9606.ENSP00000277632 | Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins |
| NRBF2 protein network | https://string-db.org/network/9606.ENSP00000277746 | Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) |
| GLUD1 protein network | https://string-db.org/network/9606.ENSP00000277865 | Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-k [...] |
| ABLIM1 protein network | https://string-db.org/network/9606.ENSP00000277895 | Actin-binding LIM protein 1; May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance; LIM domain containi [...] |
| HABP2 protein network | https://string-db.org/network/9606.ENSP00000277903 | Hyaluronan-binding protein 2; Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the [...] |
| NPFFR1 protein network | https://string-db.org/network/9606.ENSP00000277942 | Neuropeptide FF receptor 1; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occu [...] |
| FUOM protein network | https://string-db.org/network/9606.ENSP00000278025 | Fucose mutarotase; Involved in the interconversion between alpha- and beta- L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is [...] |
| PAOX protein network | https://string-db.org/network/9606.ENSP00000278060 | Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can als [...] |
| PPRC1 protein network | https://string-db.org/network/9606.ENSP00000278070 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and ce [...] |
| ITPRIP protein network | https://string-db.org/network/9606.ENSP00000278071 | Inositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release; Belongs to the ITPRIP family |
| LIN7C protein network | https://string-db.org/network/9606.ENSP00000278193 | Protein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...] |
| LRRC4C protein network | https://string-db.org/network/9606.ENSP00000278198 | Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons; I-set domain containing |
| IMMP1L protein network | https://string-db.org/network/9606.ENSP00000278200 | Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into th [...] |
| SAA4 protein network | https://string-db.org/network/9606.ENSP00000278222 | Serum amyloid A-4 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family |
| PGAP2 protein network | https://string-db.org/network/9606.ENSP00000278243 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similari [...] |
| SCGB1A1 protein network | https://string-db.org/network/9606.ENSP00000278282 | Uteroglobin; Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2; Secretoglobins |
| ZNF214 protein network | https://string-db.org/network/9606.ENSP00000278314 | Zinc finger protein 214; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TNNT3 protein network | https://string-db.org/network/9606.ENSP00000278317 | Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin A [...] |
| ZNF215 protein network | https://string-db.org/network/9606.ENSP00000278319 | Zinc finger protein 215; May be involved in transcriptional regulation; SCAN domain containing |
| HSD17B12 protein network | https://string-db.org/network/9606.ENSP00000278353 | Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows th [...] |
| SLC1A2 protein network | https://string-db.org/network/9606.ENSP00000278379 | Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter [...] |
| SERPING1 protein network | https://string-db.org/network/9606.ENSP00000278407 | Plasma protease C1 inhibitor; Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May pla [...] |
| OR5F1 protein network | https://string-db.org/network/9606.ENSP00000278409 | Olfactory receptor 5F1; Odorant receptor; Olfactory receptors, family 5 |
| SSRP1 protein network | https://string-db.org/network/9606.ENSP00000278412 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a [...] |
| TMX2 protein network | https://string-db.org/network/9606.ENSP00000278422 | Thioredoxin related transmembrane protein 2; Protein disulfide isomerases |
| SLC43A1 protein network | https://string-db.org/network/9606.ENSP00000278426 | Large neutral amino acids transporter small subunit 3; Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 a [...] |
| C11orf73 protein network | https://string-db.org/network/9606.ENSP00000278483 | Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins in [...] |
| ENDOD1 protein network | https://string-db.org/network/9606.ENSP00000278505 | Endonuclease domain-containing 1 protein; May act as a DNase and a RNase |
| CCDC82 protein network | https://string-db.org/network/9606.ENSP00000278520 | Coiled-coil domain containing 82 |
| TENM4 protein network | https://string-db.org/network/9606.ENSP00000278550 | Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during [...] |
| CAPN5 protein network | https://string-db.org/network/9606.ENSP00000278559 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease; C2 domain containing |
| PAK1 protein network | https://string-db.org/network/9606.ENSP00000278568 | Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton d [...] |
| RPS3 protein network | https://string-db.org/network/9606.ENSP00000278572 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bo [...] |
| ZC3H12C protein network | https://string-db.org/network/9606.ENSP00000278590 | Probable ribonuclease ZC3H12C; May function as RNase and regulate the levels of target RNA species; Belongs to the ZC3H12 family |
| C11orf52 protein network | https://string-db.org/network/9606.ENSP00000278601 | Uncharacterized protein C11orf52; Chromosome 11 open reading frame 52 |
| NPAT protein network | https://string-db.org/network/9606.ENSP00000278612 | Protein NPAT; Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 gene [...] |
| ATM protein network | https://string-db.org/network/9606.ENSP00000278616 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A l [...] |
| AASDHPPT protein network | https://string-db.org/network/9606.ENSP00000278618 | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopant [...] |
| LAMTOR1 protein network | https://string-db.org/network/9606.ENSP00000278671 | Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...] |
| HMBS protein network | https://string-db.org/network/9606.ENSP00000278715 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family |
| ST14 protein network | https://string-db.org/network/9606.ENSP00000278742 | Suppressor of tumorigenicity 14 protein; Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of [...] |
| OVOL2 protein network | https://string-db.org/network/9606.ENSP00000278780 | Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal tran [...] |
| MTA2 protein network | https://string-db.org/network/9606.ENSP00000278823 | Metastasis-associated protein MTA2; May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins; [...] |
| TMEM138 protein network | https://string-db.org/network/9606.ENSP00000278826 | Transmembrane protein 138; Required for ciliogenesis |
| FADS3 protein network | https://string-db.org/network/9606.ENSP00000278829 | Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturate [...] |
| ROM1 protein network | https://string-db.org/network/9606.ENSP00000278833 | Rod outer segment membrane protein 1; May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is [...] |
| MYRF protein network | https://string-db.org/network/9606.ENSP00000278836 | Myelin regulatory factor; Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal [...] |
| FADS2 protein network | https://string-db.org/network/9606.ENSP00000278840 | Fatty acid desaturase 2; Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) li [...] |
| ZP1 protein network | https://string-db.org/network/9606.ENSP00000278853 | Zona pellucida sperm-binding protein 1; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy [...] |
| OOSP2 protein network | https://string-db.org/network/9606.ENSP00000278855 | Oocyte secreted protein 2 |
| MS4A3 protein network | https://string-db.org/network/9606.ENSP00000278865 | Membrane-spanning 4-domains subfamily A member 3; Hematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through i [...] |
| FRG1B protein network | https://string-db.org/network/9606.ENSP00000278882 | FSHD region gene 1 family, member B |
| NINL protein network | https://string-db.org/network/9606.ENSP00000278886 | Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell peripher [...] |
| MS4A2 protein network | https://string-db.org/network/9606.ENSP00000278888 | High affinity immunoglobulin epsilon receptor subunit beta; High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required [...] |
| EI24 protein network | https://string-db.org/network/9606.ENSP00000278903 | Etoposide-induced protein 2.4 homolog; Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity); B [...] |
| FEZ1 protein network | https://string-db.org/network/9606.ENSP00000278919 | Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to re [...] |
| ESAM protein network | https://string-db.org/network/9606.ENSP00000278927 | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction; IgCAM CXADR-related subfamily |
| CEP164 protein network | https://string-db.org/network/9606.ENSP00000278935 | Centrosomal protein of 164 kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface [...] |
| MPZL2 protein network | https://string-db.org/network/9606.ENSP00000278937 | Myelin protein zero-like protein 2; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family |
| SCN2B protein network | https://string-db.org/network/9606.ENSP00000278947 | Sodium channel subunit beta-2; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the pla [...] |
| MPZL3 protein network | https://string-db.org/network/9606.ENSP00000278949 | Myelin protein zero-like protein 3; Mediates homophilic cell-cell adhesion; Belongs to the myelin P0 protein family |
| COMMD7 protein network | https://string-db.org/network/9606.ENSP00000278980 | COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity |
| MYL9 protein network | https://string-db.org/network/9606.ENSP00000279022 | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. [...] |
| KIAA1755 protein network | https://string-db.org/network/9606.ENSP00000279024 | Uncharacterized protein KIAA1755; KIAA1755 |
| SLC13A3 protein network | https://string-db.org/network/9606.ENSP00000279027 | Solute carrier family 13 member 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent [...] |
| OCSTAMP protein network | https://string-db.org/network/9606.ENSP00000279028 | Osteoclast stimulatory transmembrane protein; Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion [...] |
| PIGT protein network | https://string-db.org/network/9606.ENSP00000279036 | GPI transamidase component PIG-T; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates; Belongs to the PIGT f [...] |
| SPINT4 protein network | https://string-db.org/network/9606.ENSP00000279058 | Serine peptidase inhibitor, Kunitz type 4 |
| LSM14B protein network | https://string-db.org/network/9606.ENSP00000279068 | Protein LSM14 homolog B; May play a role in control of mRNA translation; LSm proteins |
| CABLES2 protein network | https://string-db.org/network/9606.ENSP00000279101 | CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition |
| AIP protein network | https://string-db.org/network/9606.ENSP00000279146 | AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targetin [...] |
| ORAOV1 protein network | https://string-db.org/network/9606.ENSP00000279147 | The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery . May be required for biogenesi [...] |
| GPHA2 protein network | https://string-db.org/network/9606.ENSP00000279168 | Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP pro [...] |
| SLC22A9 protein network | https://string-db.org/network/9606.ENSP00000279178 | Solute carrier family 22 member 9; Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specificall [...] |
| NUDT22 protein network | https://string-db.org/network/9606.ENSP00000279206 | Nucleoside diphosphate-linked moiety X motif 22; Nudix hydrolase family |
| FERMT3 protein network | https://string-db.org/network/9606.ENSP00000279227 | Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-m [...] |
| MRPL49 protein network | https://string-db.org/network/9606.ENSP00000279242 | Mitochondrial ribosomal protein L49 |
| CDC42EP2 protein network | https://string-db.org/network/9606.ENSP00000279249 | Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...] |
| TM7SF2 protein network | https://string-db.org/network/9606.ENSP00000279263 | Delta(14)-sterol reductase; Involved in the conversion of lanosterol to cholesterol |
| VPS51 protein network | https://string-db.org/network/9606.ENSP00000279281 | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...] |
| PPP4C protein network | https://string-db.org/network/9606.ENSP00000279387 | Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs [...] |
| HIRIP3 protein network | https://string-db.org/network/9606.ENSP00000279392 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones |
| MMP10 protein network | https://string-db.org/network/9606.ENSP00000279441 | Stromelysin-2; Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase; Belongs to the peptidase M10A family |
| DUSP6 protein network | https://string-db.org/network/9606.ENSP00000279488 | Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal [...] |
| PRB4 protein network | https://string-db.org/network/9606.ENSP00000279575 | Basic salivary proline-rich protein 4; Proline rich protein BstNI subfamily 4 |
| OR8K1 protein network | https://string-db.org/network/9606.ENSP00000279783 | Olfactory receptor 8K1; Odorant receptor; Olfactory receptors, family 8 |
| OR5M9 protein network | https://string-db.org/network/9606.ENSP00000279791 | Olfactory receptor 5M9; Odorant receptor; Olfactory receptors, family 5 |
| CTF1 protein network | https://string-db.org/network/9606.ENSP00000279804 | Cardiotrophin-1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor; Interleukin 6 type cytokine family |
| ARID5B protein network | https://string-db.org/network/9606.ENSP00000279873 | AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by for [...] |
| UHRF1BP1L protein network | https://string-db.org/network/9606.ENSP00000279907 | UHRF1-binding protein 1-like; UHRF1 binding protein 1 like |
| KIAA1328 protein network | https://string-db.org/network/9606.ENSP00000280020 | Protein hinderin; Competes with SMC1 for binding to SMC3. May affect the availability of SMC3 to engage in the formation of multimeric protein complexes |
| FAM124A protein network | https://string-db.org/network/9606.ENSP00000280057 | Protein FAM124A; Family with sequence similarity 124 member A; Belongs to the FAM124 family |
| MIA2 protein network | https://string-db.org/network/9606.ENSP00000280082 | Endoplasmic reticulum export factor CTAGE5; Melanoma inhibitory activity 2; MIA family |
| HNMT protein network | https://string-db.org/network/9606.ENSP00000280097 | Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine; Belongs to the class I-li [...] |
| SPOPL protein network | https://string-db.org/network/9606.ENSP00000280098 | Speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of [...] |
| PDCD4 protein network | https://string-db.org/network/9606.ENSP00000280154 | Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicas [...] |
| ADRA2A protein network | https://string-db.org/network/9606.ENSP00000280155 | Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agoni [...] |
| GPM6A protein network | https://string-db.org/network/9606.ENSP00000280187 | Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in n [...] |
| WDR17 protein network | https://string-db.org/network/9606.ENSP00000280190 | WD repeat-containing protein 17; WD repeat domain containing |
| SPATA4 protein network | https://string-db.org/network/9606.ENSP00000280191 | Spermatogenesis-associated protein 4; Spermatogenesis associated 4 |
| CD226 protein network | https://string-db.org/network/9606.ENSP00000280200 | CD226 antigen; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECT [...] |
| FSIP1 protein network | https://string-db.org/network/9606.ENSP00000280236 | Fibrous sheath interacting protein 1; Belongs to the FSIP1 family |
| CCDC83 protein network | https://string-db.org/network/9606.ENSP00000280245 | Coiled-coil domain containing 83 |
| PRSS23 protein network | https://string-db.org/network/9606.ENSP00000280258 | Serine protease 23; Belongs to the peptidase S1 family |
| PPP1R1C protein network | https://string-db.org/network/9606.ENSP00000280295 | Protein phosphatase 1 regulatory subunit 1C; Inhibitor of protein-phosphatase 1. Promotes cell growth and cell cycle progress at the G1/S transition. May increase cell susceptibility to TNF-induc [...] |
| C11orf53 protein network | https://string-db.org/network/9606.ENSP00000280325 | Uncharacterized protein C11orf53; Chromosome 11 open reading frame 53 |
| CCT5 protein network | https://string-db.org/network/9606.ENSP00000280326 | T-complex protein 1 subunit epsilon; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex [...] |
| DOCK1 protein network | https://string-db.org/network/9606.ENSP00000280333 | Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epith [...] |
| DLAT protein network | https://string-db.org/network/9606.ENSP00000280346 | Dihydrolipoamide S-acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tric [...] |
| PIH1D2 protein network | https://string-db.org/network/9606.ENSP00000280350 | PIH1 domain containing 2; Belongs to the PIH1 family |
| IL18 protein network | https://string-db.org/network/9606.ENSP00000280357 | Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells; Belongs to the IL-1 family |
| TEX12 protein network | https://string-db.org/network/9606.ENSP00000280358 | Testis-expressed protein 12; Testis expressed 12 |
| PTS protein network | https://string-db.org/network/9606.ENSP00000280362 | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydr [...] |
| USP15 protein network | https://string-db.org/network/9606.ENSP00000280377 | Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and R [...] |
| FREM2 protein network | https://string-db.org/network/9606.ENSP00000280481 | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required [...] |
| CRIM1 protein network | https://string-db.org/network/9606.ENSP00000280527 | Cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary f [...] |
| SEC24D protein network | https://string-db.org/network/9606.ENSP00000280551 | Protein transport protein Sec24D; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| DENR protein network | https://string-db.org/network/9606.ENSP00000280557 | Density-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of amin [...] |
| RILPL2 protein network | https://string-db.org/network/9606.ENSP00000280571 | RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, in [...] |
| TKTL2 protein network | https://string-db.org/network/9606.ENSP00000280605 | Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activit [...] |
| PRSS53 protein network | https://string-db.org/network/9606.ENSP00000280606 | Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Serine proteases |
| SLC7A11 protein network | https://string-db.org/network/9606.ENSP00000280612 | Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate; Belongs to the amino acid-polyami [...] |
| CCRN4L protein network | https://string-db.org/network/9606.ENSP00000280614 | Nocturnin; Circadian deadenylase which plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Degrades poly(A) tails of specific target mRNAs leadi [...] |
| DCP1B protein network | https://string-db.org/network/9606.ENSP00000280665 | mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7-methyl guanine cap structure from mRNA mo [...] |
| KCNA6 protein network | https://string-db.org/network/9606.ENSP00000280684 | Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective [...] |
| NGLY1 protein network | https://string-db.org/network/9606.ENSP00000280700 | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degra [...] |
| OXSM protein network | https://string-db.org/network/9606.ENSP00000280701 | 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function; Belon [...] |
| LDHAL6A protein network | https://string-db.org/network/9606.ENSP00000280706 | L-lactate dehydrogenase A-like 6A; Displays an lactate dehydrogenase activity. Significantly increases the transcriptional activity of JUN, when overexpressed |
| TMEM86A protein network | https://string-db.org/network/9606.ENSP00000280734 | Lysoplasmalogenase-like protein TMEM86A; Transmembrane protein 86A |
| TMEM263 protein network | https://string-db.org/network/9606.ENSP00000280756 | Transmembrane protein 263 |
| BTBD11 protein network | https://string-db.org/network/9606.ENSP00000280758 | Ankyrin repeat and BTB/POZ domain-containing protein BTBD11; Ankyrin repeat domain containing |
| ANK3 protein network | https://string-db.org/network/9606.ENSP00000280772 | Ankyrin-3; In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels [...] |
| PLBD2 protein network | https://string-db.org/network/9606.ENSP00000280800 | Putative phospholipase B-like 2; Putative phospholipase |
| SLC2A13 protein network | https://string-db.org/network/9606.ENSP00000280871 | Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family |
| DIP2C protein network | https://string-db.org/network/9606.ENSP00000280886 | Disco interacting protein 2 homolog C |
| DSC2 protein network | https://string-db.org/network/9606.ENSP00000280904 | Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...] |
| AKAP6 protein network | https://string-db.org/network/9606.ENSP00000280979 | A-kinase anchor protein 6; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assemblin [...] |
| FAM177A1 protein network | https://string-db.org/network/9606.ENSP00000280987 | Protein FAM177A1; Family with sequence similarity 177 member A1 |
| TMEM18 protein network | https://string-db.org/network/9606.ENSP00000281017 | Transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-s [...] |
| THRSP protein network | https://string-db.org/network/9606.ENSP00000281030 | Thyroid hormone-inducible hepatic protein; Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length [...] |
| NDUFC2 protein network | https://string-db.org/network/9606.ENSP00000281031 | NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. C [...] |
| NARS2 protein network | https://string-db.org/network/9606.ENSP00000281038 | Probable asparagine--tRNA ligase, mitochondrial; asparaginyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family |
| MYCN protein network | https://string-db.org/network/9606.ENSP00000281043 | N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells; Basic helix-loop-helix proteins |
| MSGN1 protein network | https://string-db.org/network/9606.ENSP00000281047 | Mesogenin-1; Involved in specifying the paraxial, but not dorsal, mesoderm. May regulate the expression of T-box transcription factors required for mesoderm formation and differentiation (By simi [...] |
| NUBPL protein network | https://string-db.org/network/9606.ENSP00000281081 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits [...] |
| ATP6V1G3 protein network | https://string-db.org/network/9606.ENSP00000281087 | V-type proton ATPase subunit G 3; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...] |
| FER protein network | https://string-db.org/network/9606.ENSP00000281092 | Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule as [...] |
| CDC123 protein network | https://string-db.org/network/9606.ENSP00000281141 | Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle |
| SCLT1 protein network | https://string-db.org/network/9606.ENSP00000281142 | Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) |
| C4orf33 protein network | https://string-db.org/network/9606.ENSP00000281146 | UPF0462 protein C4orf33; Chromosome 4 open reading frame 33 |
| SLC25A31 protein network | https://string-db.org/network/9606.ENSP00000281154 | ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming proces [...] |
| KHDRBS2 protein network | https://string-db.org/network/9606.ENSP00000281156 | KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site select [...] |
| PTPRO protein network | https://string-db.org/network/9606.ENSP00000281171 | Receptor-type tyrosine-protein phosphatase O; Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyt [...] |
| EPS8 protein network | https://string-db.org/network/9606.ENSP00000281172 | Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its asso [...] |
| ACAD8 protein network | https://string-db.org/network/9606.ENSP00000281182 | Isobutyryl-CoA dehydrogenase, mitochondrial; Has very high activity toward isobutyryl-CoA. Is an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Plays a role in transcriptional [...] |
| VPS26B protein network | https://string-db.org/network/9606.ENSP00000281187 | Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...] |
| QDPR protein network | https://string-db.org/network/9606.ENSP00000281243 | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Short chain dehydrogenase/re [...] |
| CGNL1 protein network | https://string-db.org/network/9606.ENSP00000281282 | Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons |
| MMAA protein network | https://string-db.org/network/9606.ENSP00000281317 | Methylmalonic aciduria type A protein, mitochondrial; GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondr [...] |
| POU4F2 protein network | https://string-db.org/network/9606.ENSP00000281321 | POU domain, class 4, transcription factor 2; DNA-binding transcriptional regulator and coregulator that recognizes and binds to the consensus octamer binding site 5'-AT[A/T]A[T/A]T[A/T]A-3' in pr [...] |
| PIGF protein network | https://string-db.org/network/9606.ENSP00000281382 | Phosphatidylinositol-glycan biosynthesis class F protein; Involved in GPI-anchor biosynthesis through the transfer of ethanolamine phosphate to the third mannose of GPI |
| ASAP2 protein network | https://string-db.org/network/9606.ENSP00000281419 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive [...] |
| BARX2 protein network | https://string-db.org/network/9606.ENSP00000281437 | Homeobox protein BarH-like 2; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM [...] |
| TMEM45B protein network | https://string-db.org/network/9606.ENSP00000281441 | Transmembrane protein 45B |
| CENPU protein network | https://string-db.org/network/9606.ENSP00000281453 | Centromere protein U; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| SLC25A4 protein network | https://string-db.org/network/9606.ENSP00000281456 | ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane; Belongs to the mitoch [...] |
| AMN1 protein network | https://string-db.org/network/9606.ENSP00000281471 | Protein AMN1 homolog; Antagonist of mitotic exit network 1 homolog |
| BICD1 protein network | https://string-db.org/network/9606.ENSP00000281474 | Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the B [...] |
| NBAS protein network | https://string-db.org/network/9606.ENSP00000281513 | Neuroblastoma-amplified sequence; Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed [...] |
| ZNF385D protein network | https://string-db.org/network/9606.ENSP00000281523 | Zinc finger protein 385D |
| TJP1 protein network | https://string-db.org/network/9606.ENSP00000281537 | Tight junction protein ZO-1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The [...] |
| GUF1 protein network | https://string-db.org/network/9606.ENSP00000281543 | Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one- codon backward translocation of tR [...] |
| PABPC3 protein network | https://string-db.org/network/9606.ENSP00000281589 | Polyadenylate-binding protein 3; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared t [...] |
| FBXO4 protein network | https://string-db.org/network/9606.ENSP00000281623 | F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradati [...] |
| PARP8 protein network | https://string-db.org/network/9606.ENSP00000281631 | poly(ADP-ribose) polymerase family member 8 |
| NVL protein network | https://string-db.org/network/9606.ENSP00000281701 | Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. May play a role in 60S ribos [...] |
| GLT1D1 protein network | https://string-db.org/network/9606.ENSP00000281703 | Glycosyltransferase 1 domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily |
| FBXW7 protein network | https://string-db.org/network/9606.ENSP00000281708 | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent prot [...] |
| RBM46 protein network | https://string-db.org/network/9606.ENSP00000281722 | Probable RNA-binding protein 46; RNA binding motif containing |
| TXNDC16 protein network | https://string-db.org/network/9606.ENSP00000281741 | Thioredoxin domain containing 16 |
| KANSL1L protein network | https://string-db.org/network/9606.ENSP00000281772 | KAT8 regulatory NSL complex subunit 1 like |
| MCHR2 protein network | https://string-db.org/network/9606.ENSP00000281806 | Melanin-concentrating hormone receptor 2; Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis |
| EPHA4 protein network | https://string-db.org/network/9606.ENSP00000281821 | Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighbori [...] |
| FARSB protein network | https://string-db.org/network/9606.ENSP00000281828 | phenylalanyl-tRNA synthetase beta subunit; Aminoacyl tRNA synthetases, Class II |
| KCNE4 protein network | https://string-db.org/network/9606.ENSP00000281830 | Potassium voltage-gated channel subfamily E member 4; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...] |
| TNFSF4 protein network | https://string-db.org/network/9606.ENSP00000281834 | Tumor necrosis factor ligand superfamily member 4; Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production; CD molecules |
| MZT2B protein network | https://string-db.org/network/9606.ENSP00000281871 | Mitotic spindle organizing protein 2B |
| CFC1B protein network | https://string-db.org/network/9606.ENSP00000281882 | Cripto, FRL-1, cryptic family 1B |
| TMEM163 protein network | https://string-db.org/network/9606.ENSP00000281924 | Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles |
| MED13L protein network | https://string-db.org/network/9606.ENSP00000281928 | Mediator of RNA polymerase II transcription subunit 13-like; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent gen [...] |
| HSPB8 protein network | https://string-db.org/network/9606.ENSP00000281938 | Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family |
| GEMIN6 protein network | https://string-db.org/network/9606.ENSP00000281950 | Gem-associated protein 6; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...] |
| TMEM178A protein network | https://string-db.org/network/9606.ENSP00000281961 | Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the i [...] |
| RNF219 protein network | https://string-db.org/network/9606.ENSP00000282003 | E3 ubiquitin ligase essential for DNA replication origin activation during S phase . Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono-ubiqu [...] |
| ZC3H13 protein network | https://string-db.org/network/9606.ENSP00000282007 | Zinc finger CCCH domain-containing protein 13; Acts as component of the WTAP complex that is involved in RNA processing and cell cycle |
| CYSLTR2 protein network | https://string-db.org/network/9606.ENSP00000282018 | Cysteinyl leukotriene receptor 2; Receptor for cysteinyl leukotrienes. The response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system. Stimulation [...] |
| GRID2 protein network | https://string-db.org/network/9606.ENSP00000282020 | Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu [...] |
| ARL11 protein network | https://string-db.org/network/9606.ENSP00000282026 | ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor; Belongs to the small GTPase superfamily. Arf family |
| SETBP1 protein network | https://string-db.org/network/9606.ENSP00000282030 | SET binding protein 1 |
| ARL14EP protein network | https://string-db.org/network/9606.ENSP00000282032 | ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicl [...] |
| EPG5 protein network | https://string-db.org/network/9606.ENSP00000282041 | Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo |
| HAUS1 protein network | https://string-db.org/network/9606.ENSP00000282058 | HAUS augmin-like complex subunit 1; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| SPC25 protein network | https://string-db.org/network/9606.ENSP00000282074 | Kinetochore protein Spc25; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for k [...] |
| PTH protein network | https://string-db.org/network/9606.ENSP00000282091 | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis [...] |
| PDE3B protein network | https://string-db.org/network/9606.ENSP00000282096 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important p [...] |
| TCF7L1 protein network | https://string-db.org/network/9606.ENSP00000282111 | Transcription factor 7-like 1; Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the ter [...] |
| CRYGC protein network | https://string-db.org/network/9606.ENSP00000282141 | Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| KCNK13 protein network | https://string-db.org/network/9606.ENSP00000282146 | Potassium channel subfamily K member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family |
| ATG10 protein network | https://string-db.org/network/9606.ENSP00000282185 | Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for [...] |
| FAM151B protein network | https://string-db.org/network/9606.ENSP00000282226 | Protein FAM151B; Family with sequence similarity 151 member B |
| GUCY1A2 protein network | https://string-db.org/network/9606.ENSP00000282249 | Guanylate cyclase soluble subunit alpha-2; Has guanylyl cyclase on binding to the beta-1 subunit |
| CWF19L2 protein network | https://string-db.org/network/9606.ENSP00000282251 | CWF19-like protein 2; CWF19 like 2, cell cycle control; Belongs to the CWF19 family |
| ANKRD44 protein network | https://string-db.org/network/9606.ENSP00000282272 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...] |
| MARS2 protein network | https://string-db.org/network/9606.ENSP00000282276 | Methionine--tRNA ligase, mitochondrial; methionyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I |
| ZNF547 protein network | https://string-db.org/network/9606.ENSP00000282282 | Zinc finger protein 547; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF773 protein network | https://string-db.org/network/9606.ENSP00000282292 | Zinc finger protein 773; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF551 protein network | https://string-db.org/network/9606.ENSP00000282296 | Zinc finger protein 551; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF256 protein network | https://string-db.org/network/9606.ENSP00000282308 | Zinc finger protein 256; Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZSCAN1 protein network | https://string-db.org/network/9606.ENSP00000282326 | Zinc finger and SCAN domain-containing protein 1; May be involved in transcriptional regulation; SCAN domain containing |
| USP12 protein network | https://string-db.org/network/9606.ENSP00000282344 | Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not [...] |
| CAMK4 protein network | https://string-db.org/network/9606.ENSP00000282356 | Calcium/calmodulin-dependent protein kinase type IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phos [...] |
| TRIM36 protein network | https://string-db.org/network/9606.ENSP00000282369 | E3 ubiquitin-protein ligase TRIM36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cel [...] |
| TMED7-TICAM2 protein network | https://string-db.org/network/9606.ENSP00000282382 | Transmembrane emp24 domain-containing protein 7; TMED7-TICAM2 readthrough |
| ZFP36L2 protein network | https://string-db.org/network/9606.ENSP00000282388 | mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail remov [...] |
| FLT1 protein network | https://string-db.org/network/9606.ENSP00000282397 | Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic v [...] |
| PLEKHH2 protein network | https://string-db.org/network/9606.ENSP00000282406 | Pleckstrin homology domain-containing family H member 2; In the kidney glomerulus may play a role in linking podocyte foot processes to the glomerular basement membrane. May be involved in stabil [...] |
| PPM1B protein network | https://string-db.org/network/9606.ENSP00000282412 | Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylati [...] |
| IGSF10 protein network | https://string-db.org/network/9606.ENSP00000282466 | Immunoglobulin superfamily member 10; Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons) (By similarity). May be involved in the mainte [...] |
| MBNL1 protein network | https://string-db.org/network/9606.ENSP00000282486 | Muscleblind-like protein 1; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...] |
| GRIA4 protein network | https://string-db.org/network/9606.ENSP00000282499 | Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...] |
| UGT3A2 protein network | https://string-db.org/network/9606.ENSP00000282507 | UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...] |
| NIPBL protein network | https://string-db.org/network/9606.ENSP00000282516 | Nipped-B-like protein; Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promot [...] |
| GADL1 protein network | https://string-db.org/network/9606.ENSP00000282538 | Acidic amino acid decarboxylase GADL1; May catalyze the decarboxylation of aspartate, cysteine sulfinic acid, and cysteic acid to beta-alanine, hypotaurine and taurine, respectively. Does not exh [...] |
| GPD1L protein network | https://string-db.org/network/9606.ENSP00000282541 | Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activati [...] |
| OTX1 protein network | https://string-db.org/network/9606.ENSP00000282549 | Homeobox protein OTX1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'; PRD class homeoboxes and pseudogenes |
| GJA1 protein network | https://string-db.org/network/9606.ENSP00000282561 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connex [...] |
| GMCL1 protein network | https://string-db.org/network/9606.ENSP00000282570 | Germ cell-less protein-like 1; Possible function in spermatogenesis. Enhances the degradation of MDM2 and increases the amount of p53 probably by modulating the nucleocytoplasmic transport (By si [...] |
| CCNO protein network | https://string-db.org/network/9606.ENSP00000282572 | Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS t [...] |
| ITGA1 protein network | https://string-db.org/network/9606.ENSP00000282588 | Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Involved in anchorage-dependent, negati [...] |
| CATSPER3 protein network | https://string-db.org/network/9606.ENSP00000282611 | Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...] |
| FAM21A protein network | https://string-db.org/network/9606.ENSP00000282633 | WASH complex subunit 2A; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruit [...] |
| TCTEX1D1 protein network | https://string-db.org/network/9606.ENSP00000282670 | Tctex1 domain containing 1; Belongs to the dynein light chain Tctex-type family |
| BMP3 protein network | https://string-db.org/network/9606.ENSP00000282701 | Bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification; Bone morphogenetic [...] |
| HHEX protein network | https://string-db.org/network/9606.ENSP00000282728 | Hematopoietically-expressed homeobox protein HHEX; Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior ident [...] |
| GGPS1 protein network | https://string-db.org/network/9606.ENSP00000282841 | Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and gerany [...] |
| ADAMTS18 protein network | https://string-db.org/network/9606.ENSP00000282849 | ADAM metallopeptidase with thrombospondin type 1 motif 18 |
| ZNF117 protein network | https://string-db.org/network/9606.ENSP00000282869 | Zinc finger protein 117; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RAB3C protein network | https://string-db.org/network/9606.ENSP00000282878 | Ras-related protein Rab-3C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family |
| MED21 protein network | https://string-db.org/network/9606.ENSP00000282892 | Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| PLOD2 protein network | https://string-db.org/network/9606.ENSP00000282903 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units a [...] |
| STK32B protein network | https://string-db.org/network/9606.ENSP00000282908 | Serine/threonine kinase 32B |
| ZIC1 protein network | https://string-db.org/network/9606.ENSP00000282928 | Zinc finger protein ZIC 1; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cor [...] |
| CENPH protein network | https://string-db.org/network/9606.ENSP00000283006 | Centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| TEKT5 protein network | https://string-db.org/network/9606.ENSP00000283025 | Tektin-5; May be a structural component of the sperm flagellum; Tektins |
| NUBP1 protein network | https://string-db.org/network/9606.ENSP00000283027 | Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP [...] |
| TXNDC11 protein network | https://string-db.org/network/9606.ENSP00000283033 | Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex co [...] |
| RIOK2 protein network | https://string-db.org/network/9606.ENSP00000283109 | Serine/threonine-protein kinase RIO2; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre- ribosome particles (pre-40S) from the [...] |
| SMARCA5 protein network | https://string-db.org/network/9606.ENSP00000283131 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing [...] |
| SYCP2L protein network | https://string-db.org/network/9606.ENSP00000283141 | Synaptonemal complex protein 2-like; Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes; Belongs to the SYCP2 family |
| BMP6 protein network | https://string-db.org/network/9606.ENSP00000283147 | Bone morphogenetic protein 6; Induces cartilage and bone formation; Bone morphogenetic proteins |
| UXS1 protein network | https://string-db.org/network/9606.ENSP00000283148 | UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminogl [...] |
| HNRNPU protein network | https://string-db.org/network/9606.ENSP00000283179 | Heterogeneous nuclear ribonucleoprotein U; DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, m [...] |
| RANBP2 protein network | https://string-db.org/network/9606.ENSP00000283195 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F [...] |
| TMEM87B protein network | https://string-db.org/network/9606.ENSP00000283206 | Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN); Belongs to the LU7TM family. TMEM87 subfamily |
| OR14K1 protein network | https://string-db.org/network/9606.ENSP00000283225 | Olfactory receptor 14K1; Odorant receptor; Olfactory receptors, family 14 |
| PTPRR protein network | https://string-db.org/network/9606.ENSP00000283228 | Receptor-type tyrosine-protein phosphatase R; Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephos [...] |
| CCDC148 protein network | https://string-db.org/network/9606.ENSP00000283233 | Coiled-coil domain containing 148 |
| PLA2R1 protein network | https://string-db.org/network/9606.ENSP00000283243 | Secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2- IIA/PLA2G2A. Also able to bind to snake P [...] |
| ITGB6 protein network | https://string-db.org/network/9606.ENSP00000283249 | Integrin beta-6; Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-med [...] |
| SCN3A protein network | https://string-db.org/network/9606.ENSP00000283254 | Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| FEZF2 protein network | https://string-db.org/network/9606.ENSP00000283268 | Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neu [...] |
| CD96 protein network | https://string-db.org/network/9606.ENSP00000283285 | T-cell surface protein tactile; May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting [...] |
| ATG3 protein network | https://string-db.org/network/9606.ENSP00000283290 | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent [...] |
| GPR116 protein network | https://string-db.org/network/9606.ENSP00000283296 | Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function; Belongs to the G-protein coupled rec [...] |
| GPR115 protein network | https://string-db.org/network/9606.ENSP00000283303 | Adhesion G protein-coupled receptor F4; Orphan receptor |
| FRMD1 protein network | https://string-db.org/network/9606.ENSP00000283309 | FERM domain containing 1 |
| TRAPPC8 protein network | https://string-db.org/network/9606.ENSP00000283351 | Trafficking protein particle complex subunit 8; May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex |
| FAM81B protein network | https://string-db.org/network/9606.ENSP00000283357 | Protein FAM81B; Family with sequence similarity 81 member B |
| LPCAT1 protein network | https://string-db.org/network/9606.ENSP00000283415 | Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent (By similarity). Mediates the conversion of 1- acyl-sn- [...] |
| PLEKHG4B protein network | https://string-db.org/network/9606.ENSP00000283426 | Pleckstrin homology and RhoGEF domain containing G4B |
| ZDHHC11 protein network | https://string-db.org/network/9606.ENSP00000283441 | Probable palmitoyltransferase ZDHHC11; Zinc finger DHHC-type containing 11; Belongs to the DHHC palmitoyltransferase family |
| UBALD1 protein network | https://string-db.org/network/9606.ENSP00000283474 | UBA-like domain-containing protein 1; UBA like domain containing 1 |
| TEX29 protein network | https://string-db.org/network/9606.ENSP00000283547 | Testis-expressed protein 29; Testis expressed 29 |
| SPACA7 protein network | https://string-db.org/network/9606.ENSP00000283550 | Sperm acrosome-associated protein 7; Involved in fertilization. Seems not to play a direct role in sperm-egg binding or gamete fusion |
| UBP1 protein network | https://string-db.org/network/9606.ENSP00000283629 | Upstream-binding protein 1; Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-glo [...] |
| RMND5A protein network | https://string-db.org/network/9606.ENSP00000283632 | Protein RMD5 homolog A; Required for meiotic nuclear division 5 homolog A; CTLH complex |
| RPIA protein network | https://string-db.org/network/9606.ENSP00000283646 | Ribose 5-phosphate isomerase A; Belongs to the ribose 5-phosphate isomerase family |
| VILL protein network | https://string-db.org/network/9606.ENSP00000283713 | Villin-like protein; Possible tumor suppressor; Gelsolin/villins |
| SERPINB3 protein network | https://string-db.org/network/9606.ENSP00000283752 | Serpin B3; May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of [...] |
| HGD protein network | https://string-db.org/network/9606.ENSP00000283871 | Homogentisate 1,2-dioxygenase |
| GTF2E1 protein network | https://string-db.org/network/9606.ENSP00000283875 | General transcription factor IIE subunit 1; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Bo [...] |
| CFDP1 protein network | https://string-db.org/network/9606.ENSP00000283882 | Craniofacial development protein 1; May play a role during embryogenesis |
| TMPRSS11D protein network | https://string-db.org/network/9606.ENSP00000283916 | Transmembrane protease serine 11D; May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bro [...] |
| HOXA10 protein network | https://string-db.org/network/9606.ENSP00000283921 | Homeobox protein Hox-A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| JAZF1 protein network | https://string-db.org/network/9606.ENSP00000283928 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of [...] |
| FBXO36 protein network | https://string-db.org/network/9606.ENSP00000283946 | F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| CEBPG protein network | https://string-db.org/network/9606.ENSP00000284000 | CCAAT/enhancer-binding protein gamma; Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) [...] |
| DDAH1 protein network | https://string-db.org/network/9606.ENSP00000284031 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in t [...] |
| DGKE protein network | https://string-db.org/network/9606.ENSP00000284061 | Diacylglycerol kinase epsilon; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the sy [...] |
| MSI2 protein network | https://string-db.org/network/9606.ENSP00000284073 | RNA-binding protein Musashi homolog 2; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cel [...] |
| HS3ST3A1 protein network | https://string-db.org/network/9606.ENSP00000284110 | Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosa [...] |
| GDPD1 protein network | https://string-db.org/network/9606.ENSP00000284116 | Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (l [...] |
| SEMA3D protein network | https://string-db.org/network/9606.ENSP00000284136 | Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity); Sema [...] |
| ASB17 protein network | https://string-db.org/network/9606.ENSP00000284142 | Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| GRAP protein network | https://string-db.org/network/9606.ENSP00000284154 | GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway; SH2 domain containing |
| IMPACT protein network | https://string-db.org/network/9606.ENSP00000284202 | Protein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor [...] |
| THY1 protein network | https://string-db.org/network/9606.ENSP00000284240 | Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain; CD molecules |
| C16orf74 protein network | https://string-db.org/network/9606.ENSP00000284245 | Uncharacterized protein C16orf74; Chromosome 16 open reading frame 74 |
| JPH3 protein network | https://string-db.org/network/9606.ENSP00000284262 | Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...] |
| ANKH protein network | https://string-db.org/network/9606.ENSP00000284268 | Progressive ankylosis protein homolog; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family |
| UBASH3B protein network | https://string-db.org/network/9606.ENSP00000284273 | Ubiquitin-associated and SH3 domain-containing protein B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target [...] |
| OTULIN protein network | https://string-db.org/network/9606.ENSP00000284274 | Ubiquitin thioesterase otulin; Deubiquitinase that specifically removes linear ('Met- 1'-linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune respo [...] |
| OR8A1 protein network | https://string-db.org/network/9606.ENSP00000284287 | Olfactory receptor 8A1; Odorant receptor; Olfactory receptors, family 8 |
| PANX3 protein network | https://string-db.org/network/9606.ENSP00000284288 | Pannexin-3; Structural component of the gap junctions and the hemichannels; Pannexins |
| NRGN protein network | https://string-db.org/network/9606.ENSP00000284292 | Neurogranin; Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By si [...] |
| GPR15 protein network | https://string-db.org/network/9606.ENSP00000284311 | G-protein coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection; G protein-coupled receptors, Class A orphans |
| TOMM70A protein network | https://string-db.org/network/9606.ENSP00000284320 | Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins |
| ABI3BP protein network | https://string-db.org/network/9606.ENSP00000284322 | Target of Nesh-SH3; Fibronectin type III domain containing |
| CERS3 protein network | https://string-db.org/network/9606.ENSP00000284382 | Ceramide synthase 3; Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarit [...] |
| ABCA6 protein network | https://string-db.org/network/9606.ENSP00000284425 | ATP-binding cassette sub-family A member 6; Probable transporter which may play a role in macrophage lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family |
| C4orf19 protein network | https://string-db.org/network/9606.ENSP00000284437 | Uncharacterized protein C4orf19; Chromosome 4 open reading frame 19 |
| UCHL1 protein network | https://string-db.org/network/9606.ENSP00000284440 | Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol proteas [...] |
| DISP1 protein network | https://string-db.org/network/9606.ENSP00000284476 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effect [...] |
| FAM167A protein network | https://string-db.org/network/9606.ENSP00000284486 | Protein FAM167A; Family with sequence similarity 167 member A; Belongs to the FAM167 (SEC) family |
| NEIL2 protein network | https://string-db.org/network/9606.ENSP00000284503 | Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of [...] |
| ATP8B4 protein network | https://string-db.org/network/9606.ENSP00000284509 | Probable phospholipid-transporting ATPase IM; Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| WNT3A protein network | https://string-db.org/network/9606.ENSP00000284523 | Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neur [...] |
| TRIM11 protein network | https://string-db.org/network/9606.ENSP00000284551 | E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly- [...] |
| PPP1R3A protein network | https://string-db.org/network/9606.ENSP00000284601 | Protein phosphatase 1 regulatory subunit 3A; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, m [...] |
| CCSAP protein network | https://string-db.org/network/9606.ENSP00000284617 | Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with pol [...] |
| ASZ1 protein network | https://string-db.org/network/9606.ENSP00000284629 | Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which [...] |
| SH3RF1 protein network | https://string-db.org/network/9606.ENSP00000284637 | E3 ubiquitin-protein ligase SH3RF1; Acts as a scaffold protein, contributes to Rac-induced signal transduction such as JNKs (MAPK8 and MAPK9) activation and induces apoptosis. Within a signaling [...] |
| KLHL41 protein network | https://string-db.org/network/9606.ENSP00000284669 | Kelch-like protein 41; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting la [...] |
| GPR26 protein network | https://string-db.org/network/9606.ENSP00000284674 | G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in [...] |
| DHX32 protein network | https://string-db.org/network/9606.ENSP00000284690 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; DEAH-box helicase 32; Belongs to the DEAD box helicase family. DEAH subfamily |
| C10orf90 protein network | https://string-db.org/network/9606.ENSP00000284694 | Centrosomal protein C10orf90; Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner (By similarity [...] |
| OLA1 protein network | https://string-db.org/network/9606.ENSP00000284719 | Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. Y [...] |
| ATP5G3 protein network | https://string-db.org/network/9606.ENSP00000284727 | ATP synthase F(0) complex subunit C3, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...] |
| PDLIM3 protein network | https://string-db.org/network/9606.ENSP00000284770 | PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells; LIM domain containing |
| LY96 protein network | https://string-db.org/network/9606.ENSP00000284818 | Lymphocyte antigen 96; Binds bacterial lipopolysaccharide (LPS). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wa [...] |
| CXADR protein network | https://string-db.org/network/9606.ENSP00000284878 | Coxsackievirus and adenovirus receptor; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. [...] |
| C21orf91 protein network | https://string-db.org/network/9606.ENSP00000284881 | Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post- migratory cortical projection neurons by modulating [...] |
| TMPRSS15 protein network | https://string-db.org/network/9606.ENSP00000284885 | Enteropeptidase; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin w [...] |
| APP protein network | https://string-db.org/network/9606.ENSP00000284981 | Amyloid-beta A4 protein; N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6); Endogenous ligands |
| ADAMTS1 protein network | https://string-db.org/network/9606.ENSP00000284984 | A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), [...] |
| ADAMTS5 protein network | https://string-db.org/network/9606.ENSP00000284987 | A disintegrin and metalloproteinase with thrombospondin motifs 5; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell [...] |
| TSEN2 protein network | https://string-db.org/network/9606.ENSP00000284995 | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splic [...] |
| SLFN13 protein network | https://string-db.org/network/9606.ENSP00000285013 | Endoribonuclease that cleaves tRNAs and rRNAs . Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem . Does not act on tRNA(Sec) . Able to restrict HIV-1 virus replication; abil [...] |
| WNT7A protein network | https://string-db.org/network/9606.ENSP00000285018 | Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. Signaling by Wnt-7a allows sexually dimorphic development of the muller [...] |
| XPC protein network | https://string-db.org/network/9606.ENSP00000285021 | DNA repair protein complementing XP-C cells; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has onl [...] |
| MYO5B protein network | https://string-db.org/network/9606.ENSP00000285039 | Unconventional myosin-Vb; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not fo [...] |
| FGD5 protein network | https://string-db.org/network/9606.ENSP00000285046 | FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activ [...] |
| FLCN protein network | https://string-db.org/network/9606.ENSP00000285071 | Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; DENN/MADD domain co [...] |
| OXNAD1 protein network | https://string-db.org/network/9606.ENSP00000285083 | Oxidoreductase NAD-binding domain-containing protein 1; Oxidoreductase NAD binding domain containing 1 |
| ACAA2 protein network | https://string-db.org/network/9606.ENSP00000285093 | 3-ketoacyl-CoA thiolase, mitochondrial; Abolishes BNIP3-mediated apoptosis and mitochondrial damage |
| SKA1 protein network | https://string-db.org/network/9606.ENSP00000285116 | Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Require [...] |
| USP43 protein network | https://string-db.org/network/9606.ENSP00000285199 | Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as tha [...] |
| RAB6B protein network | https://string-db.org/network/9606.ENSP00000285208 | Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells; Belongs to the small GTP [...] |
| ABCC3 protein network | https://string-db.org/network/9606.ENSP00000285238 | Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export o [...] |
| ANKRD40 protein network | https://string-db.org/network/9606.ENSP00000285243 | Ankyrin repeat domain-containing protein 40; Ankyrin repeat domain containing |
| VOPP1 protein network | https://string-db.org/network/9606.ENSP00000285279 | Vesicular, overexpressed in cancer, prosurvival protein 1; Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response [...] |
| RPMS17 protein network | https://string-db.org/network/9606.ENSP00000285298 | Mitochondrial ribosomal protein S17; Belongs to the universal ribosomal protein uS17 family |
| DKK2 protein network | https://string-db.org/network/9606.ENSP00000285311 | Dickkopf-related protein 2; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...] |
| CA2 protein network | https://string-db.org/network/9606.ENSP00000285379 | Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulati [...] |
| CA3 protein network | https://string-db.org/network/9606.ENSP00000285381 | Carbonic anhydrase 3; Reversible hydration of carbon dioxide; Carbonic anhydrases |
| ATP6V0D2 protein network | https://string-db.org/network/9606.ENSP00000285393 | V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryot [...] |
| ERCC3 protein network | https://string-db.org/network/9606.ENSP00000285398 | TFIIH basal transcription factor complex helicase XPB subunit; ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (N [...] |
| ODF1 protein network | https://string-db.org/network/9606.ENSP00000285402 | Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of [...] |
| KLF10 protein network | https://string-db.org/network/9606.ENSP00000285407 | Krueppel-like factor 10; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the p [...] |
| TMEM55A protein network | https://string-db.org/network/9606.ENSP00000285419 | Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol [...] |
| OTUD6B protein network | https://string-db.org/network/9606.ENSP00000285420 | [Isoform 1]: Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 . May associate with the protein synthesis initiation co [...] |
| AGPAT5 protein network | https://string-db.org/network/9606.ENSP00000285518 | 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. [...] |
| MAN2B2 protein network | https://string-db.org/network/9606.ENSP00000285599 | Epididymis-specific alpha-mannosidase; Mannosidase alpha class 2B member 2; Belongs to the glycosyl hydrolase 38 family |
| OR4K1 protein network | https://string-db.org/network/9606.ENSP00000285600 | Olfactory receptor 4K1; Odorant receptor; Olfactory receptors, family 4 |
| HSPA13 protein network | https://string-db.org/network/9606.ENSP00000285667 | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Heat shock 70kDa proteins |
| SAMSN1 protein network | https://string-db.org/network/9606.ENSP00000285670 | SAM domain-containing protein SAMSN-1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization [...] |
| C16orf87 protein network | https://string-db.org/network/9606.ENSP00000285697 | UPF0547 protein C16orf87; Chromosome 16 open reading frame 87; Belongs to the UPF0547 family |
| RHOC protein network | https://string-db.org/network/9606.ENSP00000285735 | Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule [...] |
| LONP2 protein network | https://string-db.org/network/9606.ENSP00000285737 | Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type [...] |
| TRIM74 protein network | https://string-db.org/network/9606.ENSP00000285805 | Tripartite motif containing 74; Belongs to the TRIM/RBCC family |
| NIFK protein network | https://string-db.org/network/9606.ENSP00000285814 | Nucleolar protein interacting with the FHA domain of MKI67; RNA binding motif containing |
| CCDC146 protein network | https://string-db.org/network/9606.ENSP00000285871 | Coiled-coil domain containing 146 |
| GEMIN5 protein network | https://string-db.org/network/9606.ENSP00000285873 | Gem-associated protein 5; Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceos [...] |
| MAGEC1 protein network | https://string-db.org/network/9606.ENSP00000285879 | Melanoma-associated antigen C1; MAGE family member C1 |
| LRGUK protein network | https://string-db.org/network/9606.ENSP00000285928 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspect [...] |
| AKR1B1 protein network | https://string-db.org/network/9606.ENSP00000285930 | Aldose reductase; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies; Belongs [...] |
| SETD9 protein network | https://string-db.org/network/9606.ENSP00000285947 | SET domain containing 9 |
| CYP26C1 protein network | https://string-db.org/network/9606.ENSP00000285949 | Cytochrome P450 26C1; Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate); Belongs to the cytoc [...] |
| NUP205 protein network | https://string-db.org/network/9606.ENSP00000285968 | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC; Armad [...] |
| CYP2C18 protein network | https://string-db.org/network/9606.ENSP00000285979 | Cytochrome P450 2C18; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a va [...] |
| C1orf112 protein network | https://string-db.org/network/9606.ENSP00000286031 | Uncharacterized protein C1orf112; Chromosome 1 open reading frame 112 |
| XAGE2B protein network | https://string-db.org/network/9606.ENSP00000286049 | X antigen family, member 2B |
| PDE11A protein network | https://string-db.org/network/9606.ENSP00000286063 | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolys [...] |
| C10orf12 protein network | https://string-db.org/network/9606.ENSP00000286067 | Ligand-dependent corepressor; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcriptio [...] |
| RBM45 protein network | https://string-db.org/network/9606.ENSP00000286070 | RNA-binding protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development |
| PDIA4 protein network | https://string-db.org/network/9606.ENSP00000286091 | Protein disulfide-isomerase A4; Protein disulfide isomerase family A member 4; Belongs to the protein disulfide isomerase family |
| PPIL3 protein network | https://string-db.org/network/9606.ENSP00000286175 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylpro [...] |
| CASP10 protein network | https://string-db.org/network/9606.ENSP00000286186 | Caspase-10; Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the gran [...] |
| FZD7 protein network | https://string-db.org/network/9606.ENSP00000286201 | Frizzled-7; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| DEPTOR protein network | https://string-db.org/network/9606.ENSP00000286234 | DEP domain-containing mTOR-interacting protein; Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes; PDZ domain containing |
| SLC26A2 protein network | https://string-db.org/network/9606.ENSP00000286298 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Solute carriers |
| CSF1R protein network | https://string-db.org/network/9606.ENSP00000286301 | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferat [...] |
| LSM11 protein network | https://string-db.org/network/9606.ENSP00000286307 | U7 snRNA-associated Sm-like protein LSm11; Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (By similarity). Increases U7 snRNA levels but not histone [...] |
| MED7 protein network | https://string-db.org/network/9606.ENSP00000286317 | Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| TRIM42 protein network | https://string-db.org/network/9606.ENSP00000286349 | Tripartite motif-containing protein 42; Protein phosphatase 1 regulatory subunits; Belongs to the TRIM/RBCC family |
| PXYLP1 protein network | https://string-db.org/network/9606.ENSP00000286353 | 2-phosphoxylose phosphatase 1; Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosa [...] |
| ADCY8 protein network | https://string-db.org/network/9606.ENSP00000286355 | Adenylate cyclase type 8; This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity); Adenylate cyclases |
| RASA2 protein network | https://string-db.org/network/9606.ENSP00000286364 | Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4); C2 and RasGAP domain containing |
| ATP1B3 protein network | https://string-db.org/network/9606.ENSP00000286371 | Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...] |
| SMC2 protein network | https://string-db.org/network/9606.ENSP00000286398 | Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The [...] |
| TMBIM4 protein network | https://string-db.org/network/9606.ENSP00000286424 | Transmembrane BAX inhibitor motif containing 4; Belongs to the BI1 family |
| VBP1 protein network | https://string-db.org/network/9606.ENSP00000286428 | Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| NAT2 protein network | https://string-db.org/network/9606.ENSP00000286479 | Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine s [...] |
| ELMSAN1 protein network | https://string-db.org/network/9606.ENSP00000286523 | ELM2 and Myb/SANT domain containing 1 |
| FAM161B protein network | https://string-db.org/network/9606.ENSP00000286544 | Protein FAM161B; Family with sequence similarity 161 member B; Belongs to the FAM161 family |
| GNAQ protein network | https://string-db.org/network/9606.ENSP00000286548 | Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regul [...] |
| WIF1 protein network | https://string-db.org/network/9606.ENSP00000286574 | Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation |
| MMP16 protein network | https://string-db.org/network/9606.ENSP00000286614 | Matrix metalloproteinase-16; Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matr [...] |
| ADK protein network | https://string-db.org/network/9606.ENSP00000286621 | Adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular [...] |
| KCNMA1 protein network | https://string-db.org/network/9606.ENSP00000286628 | Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated [...] |
| BATF protein network | https://string-db.org/network/9606.ENSP00000286639 | Basic leucine zipper transcriptional factor ATF-like; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the [...] |
| DCK protein network | https://string-db.org/network/9606.ENSP00000286648 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not d [...] |
| ADAMTS3 protein network | https://string-db.org/network/9606.ENSP00000286657 | A disintegrin and metalloproteinase with thrombospondin motifs 3; Cleaves the propeptides of type II collagen prior to fibril assembly. Does not act on types I and III collagens; ADAM metallopept [...] |
| C8orf37 protein network | https://string-db.org/network/9606.ENSP00000286688 | Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated |
| DRAM2 protein network | https://string-db.org/network/9606.ENSP00000286692 | DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to pr [...] |
| STOM protein network | https://string-db.org/network/9606.ENSP00000286713 | Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity; Belongs to the band 7/mec-2 family |
| PPEF2 protein network | https://string-db.org/network/9606.ENSP00000286719 | Serine/threonine-protein phosphatase with EF-hands 2; May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic curr [...] |
| C15orf26 protein network | https://string-db.org/network/9606.ENSP00000286732 | Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly |
| NAAA protein network | https://string-db.org/network/9606.ENSP00000286733 | N-acylethanolamine-hydrolyzing acid amidase; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > [...] |
| ADAMTSL3 protein network | https://string-db.org/network/9606.ENSP00000286744 | ADAMTS-like protein 3; Immunoglobulin like domain containing |
| CXCL13 protein network | https://string-db.org/network/9606.ENSP00000286758 | C-X-C motif chemokine 13; Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5; Chemokine lig [...] |
| WHAMM protein network | https://string-db.org/network/9606.ENSP00000286760 | WASP homolog-associated protein with actin, membranes and microtubules; Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatu [...] |
| CCT8 protein network | https://string-db.org/network/9606.ENSP00000286788 | T-complex protein 1 subunit theta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex in [...] |
| NAA11 protein network | https://string-db.org/network/9606.ENSP00000286794 | N-alpha-acetyltransferase 11; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex; Belongs to the a [...] |
| CLDN17 protein network | https://string-db.org/network/9606.ENSP00000286808 | Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tub [...] |
| TIAM1 protein network | https://string-db.org/network/9606.ENSP00000286827 | T-lymphoma invasion and metastasis-inducing protein 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimu [...] |
| SCAF4 protein network | https://string-db.org/network/9606.ENSP00000286835 | Splicing factor, arginine/serine-rich 15; May act to physically and functionally link transcription and pre-mRNA processing; Belongs to the splicing factor SR family |
| ANKRD9 protein network | https://string-db.org/network/9606.ENSP00000286918 | Ankyrin repeat domain-containing protein 9; Ankyrin repeat domain containing |
| PCDH1 protein network | https://string-db.org/network/9606.ENSP00000287008 | Protocadherin-1; May be involved in cell-cell interaction processes and in cell adhesion; Non-clustered protocadherins |
| GDF6 protein network | https://string-db.org/network/9606.ENSP00000287020 | Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal d [...] |
| MTERF3 protein network | https://string-db.org/network/9606.ENSP00000287025 | Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription. Required for normal mitochondrial transcription and translation, and for normal as [...] |
| KCNS2 protein network | https://string-db.org/network/9606.ENSP00000287042 | Potassium voltage-gated channel subfamily S member 2; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB [...] |
| TYSND1 protein network | https://string-db.org/network/9606.ENSP00000287078 | Peroxisomal leader peptide-processing protease; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS [...] |
| CD109 protein network | https://string-db.org/network/9606.ENSP00000287097 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family |
| NODAL protein network | https://string-db.org/network/9606.ENSP00000287139 | Nodal homolog; Essential for mesoderm formation and axial patterning during embryonic development; Belongs to the TGF-beta family |
| PRG3 protein network | https://string-db.org/network/9606.ENSP00000287143 | Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 rel [...] |
| KIF6 protein network | https://string-db.org/network/9606.ENSP00000287152 | Kinesin-like protein KIF6; Kinesin family member 6; Kinesins |
| UBE2L6 protein network | https://string-db.org/network/9606.ENSP00000287156 | Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquit [...] |
| ZDHHC5 protein network | https://string-db.org/network/9606.ENSP00000287169 | Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5. Also palmitoylates FLOT2 (By similarity); Zinc fingers DHHC-type |
| CELF6 protein network | https://string-db.org/network/9606.ENSP00000287202 | CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissu [...] |
| ZFAND3 protein network | https://string-db.org/network/9606.ENSP00000287218 | Zinc finger AN1-type containing 3 |
| KAT6B protein network | https://string-db.org/network/9606.ENSP00000287239 | Histone acetyltransferase KAT6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation [...] |
| GLYATL2 protein network | https://string-db.org/network/9606.ENSP00000287275 | Glycine N-acyltransferase-like protein 2; Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and s [...] |
| AIFM1 protein network | https://string-db.org/network/9606.ENSP00000287295 | Apoptosis-inducing factor 1, mitochondrial; Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembr [...] |
| BAG4 protein network | https://string-db.org/network/9606.ENSP00000287322 | BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regul [...] |
| TBC1D31 protein network | https://string-db.org/network/9606.ENSP00000287380 | TBC1 domain family member 31; WD repeat domain containing |
| WDYHV1 protein network | https://string-db.org/network/9606.ENSP00000287387 | Protein N-terminal glutamine amidohydrolase; Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Con [...] |
| ATAD2 protein network | https://string-db.org/network/9606.ENSP00000287394 | ATPase family AAA domain-containing protein 2; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as C [...] |
| NSMCE2 protein network | https://string-db.org/network/9606.ENSP00000287437 | E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for th [...] |
| ZNF689 protein network | https://string-db.org/network/9606.ENSP00000287461 | Zinc finger protein 689; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FRRS1 protein network | https://string-db.org/network/9606.ENSP00000287474 | Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm; Belongs to the FRRS1 family |
| SASS6 protein network | https://string-db.org/network/9606.ENSP00000287482 | Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for [...] |
| COX6A2 protein network | https://string-db.org/network/9606.ENSP00000287490 | Cytochrome c oxidase subunit 6A2, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| ZIC3 protein network | https://string-db.org/network/9606.ENSP00000287538 | Zinc finger protein ZIC 3; Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal G [...] |
| LHFPL4 protein network | https://string-db.org/network/9606.ENSP00000287585 | LHFPL tetraspan subfamily member 4 |
| B3GNT7 protein network | https://string-db.org/network/9606.ENSP00000287590 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a [...] |
| BUB1B protein network | https://string-db.org/network/9606.ENSP00000287598 | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until [...] |
| PDE6D protein network | https://string-db.org/network/9606.ENSP00000287600 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated [...] |
| SST protein network | https://string-db.org/network/9606.ENSP00000287641 | Somatostatin; Somatostatin inhibits the release of somatotropin; Endogenous ligands |
| FANCD2 protein network | https://string-db.org/network/9606.ENSP00000287647 | Fanconi anemia group D2 protein; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand [...] |
| TATDN2 protein network | https://string-db.org/network/9606.ENSP00000287652 | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease |
| NOMO1 protein network | https://string-db.org/network/9606.ENSP00000287667 | Nodal modulator 1; May antagonize Nodal signaling |
| EXOG protein network | https://string-db.org/network/9606.ENSP00000287675 | Nuclease EXOG, mitochondrial; Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity |
| NTAN1 protein network | https://string-db.org/network/9606.ENSP00000287706 | Protein N-terminal asparagine amidohydrolase; Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that i [...] |
| NMNAT2 protein network | https://string-db.org/network/9606.ENSP00000287713 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic aci [...] |
| ZFYVE9 protein network | https://string-db.org/network/9606.ENSP00000287727 | Zinc finger FYVE domain-containing protein 9; Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TG [...] |
| LYZL4 protein network | https://string-db.org/network/9606.ENSP00000287748 | Lysozyme-like protein 4; May be involved in fertilization (By similarity). Has no detectable bacteriolytic and lysozyme activities in vitro (By similarity); Belongs to the glycosyl hydrolase 22 f [...] |
| SLC6A1 protein network | https://string-db.org/network/9606.ENSP00000287766 | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter [...] |
| KLHL40 protein network | https://string-db.org/network/9606.ENSP00000287777 | Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by [...] |
| TIMP4 protein network | https://string-db.org/network/9606.ENSP00000287814 | Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2 [...] |
| PPARG protein network | https://string-db.org/network/9606.ENSP00000287820 | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear recepto [...] |
| C1orf27 protein network | https://string-db.org/network/9606.ENSP00000287859 | Protein odr-4 homolog; May play a role in the trafficking of a subset of G- protein coupled receptors; Belongs to the ODR-4 family |
| PRKAG2 protein network | https://string-db.org/network/9606.ENSP00000287878 | 5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...] |
| HTR5A protein network | https://string-db.org/network/9606.ENSP00000287907 | 5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| CLDN12 protein network | https://string-db.org/network/9606.ENSP00000287916 | Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| FZD1 protein network | https://string-db.org/network/9606.ENSP00000287934 | Frizzled-1; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| HMGCR protein network | https://string-db.org/network/9606.ENSP00000287936 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids th [...] |
| GATAD1 protein network | https://string-db.org/network/9606.ENSP00000287957 | GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me) |
| IPPK protein network | https://string-db.org/network/9606.ENSP00000287996 | Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homo [...] |
| THTPA protein network | https://string-db.org/network/9606.ENSP00000288014 | Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP); Belongs to the ThTPase family |
| PDF protein network | https://string-db.org/network/9606.ENSP00000288022 | Peptide deformylase, mitochondrial; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family |
| TMED6 protein network | https://string-db.org/network/9606.ENSP00000288025 | Transmembrane p24 trafficking protein 6 |
| PDPR protein network | https://string-db.org/network/9606.ENSP00000288050 | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine; Belongs to th [...] |
| ARMC12 protein network | https://string-db.org/network/9606.ENSP00000288065 | Armadillo repeat containing 12 |
| DDX19B protein network | https://string-db.org/network/9606.ENSP00000288071 | ATP-dependent RNA helicase DDX19B; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein pa [...] |
| FUK protein network | https://string-db.org/network/9606.ENSP00000288078 | L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides |
| MDP1 protein network | https://string-db.org/network/9606.ENSP00000288087 | Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase; HAD Asp-based protein phosphatases |
| DHRS1 protein network | https://string-db.org/network/9606.ENSP00000288111 | Dehydrogenase/reductase SDR family member 1; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| KIT protein network | https://string-db.org/network/9606.ENSP00000288135 | Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and [...] |
| CACNA1D protein network | https://string-db.org/network/9606.ENSP00000288139 | Voltage-dependent L-type calcium channel subunit alpha-1D; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| IL17RB protein network | https://string-db.org/network/9606.ENSP00000288167 | Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells; Interleukin recepto [...] |
| ZNF19 protein network | https://string-db.org/network/9606.ENSP00000288177 | Zinc finger protein 19; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CCNB2 protein network | https://string-db.org/network/9606.ENSP00000288207 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily |
| ERC2 protein network | https://string-db.org/network/9606.ENSP00000288221 | ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May [...] |
| FAM81A protein network | https://string-db.org/network/9606.ENSP00000288228 | Protein FAM81A; Family with sequence similarity 81 member A; Belongs to the FAM81 family |
| MYO1E protein network | https://string-db.org/network/9606.ENSP00000288235 | Unconventional myosin-Ie; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous co [...] |
| APPL1 protein network | https://string-db.org/network/9606.ENSP00000288266 | DCC-interacting protein 13-alpha; Adapter protein that interacts with proteins involved in different cellular signaling pathways. Required for the regulation of cell proliferation in response to [...] |
| PREX2 protein network | https://string-db.org/network/9606.ENSP00000288368 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free [...] |
| C9orf43 protein network | https://string-db.org/network/9606.ENSP00000288462 | Uncharacterized protein C9orf43; Chromosome 9 open reading frame 43 |
| ZNF618 protein network | https://string-db.org/network/9606.ENSP00000288466 | Zinc finger protein 618; Zinc fingers C2H2-type |
| DGKI protein network | https://string-db.org/network/9606.ENSP00000288490 | Diacylglycerol kinase iota; Ankyrin repeat domain containing |
| C9orf91 protein network | https://string-db.org/network/9606.ENSP00000288502 | Transmembrane protein 268; Chromosome 9 open reading frame 91 |
| COQ5 protein network | https://string-db.org/network/9606.ENSP00000288532 | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-meth [...] |
| BRAF protein network | https://string-db.org/network/9606.ENSP00000288602 | Serine/threonine-protein kinase B-raf; Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hip [...] |
| PSMG3 protein network | https://string-db.org/network/9606.ENSP00000288607 | Proteasome assembly chaperone 3; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes |
| FMNL2 protein network | https://string-db.org/network/9606.ENSP00000288670 | Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics; Belongs to the formin homology family |
| SPPL3 protein network | https://string-db.org/network/9606.ENSP00000288680 | Signal peptide peptidase-like 3; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. A [...] |
| DPYSL5 protein network | https://string-db.org/network/9606.ENSP00000288699 | Dihydropyrimidinase-related protein 5; May have a function in neuronal differentiation and/or axon growth; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinas [...] |
| DRC1 protein network | https://string-db.org/network/9606.ENSP00000288710 | Dynein regulatory complex protein 1; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Required for the assembly and regulation of specific classes of [...] |
| PEX10 protein network | https://string-db.org/network/9606.ENSP00000288774 | Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes; Peroxins |
| WIPI2 protein network | https://string-db.org/network/9606.ENSP00000288828 | WD repeat domain phosphoinositide-interacting protein 2; Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature ph [...] |
| SMAD6 protein network | https://string-db.org/network/9606.ENSP00000288840 | Mothers against decapentaplegic homolog 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-ka [...] |
| CIB4 protein network | https://string-db.org/network/9606.ENSP00000288861 | Calcium and integrin binding family member 4; EF-hand domain containing |
| WDR66 protein network | https://string-db.org/network/9606.ENSP00000288912 | Cilia- and flagella-associated protein 251; May regulate cilium motility through its role in the assembly of the axonemal radial spokes; WD repeat domain containing |
| MRPL17 protein network | https://string-db.org/network/9606.ENSP00000288937 | Mitochondrial ribosomal protein L17 |
| DUSP2 protein network | https://string-db.org/network/9606.ENSP00000288943 | Dual specificity protein phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2; Belongs to the protein-tyrosine phosph [...] |
| GRHL3 protein network | https://string-db.org/network/9606.ENSP00000288955 | Grainyhead-like protein 3 homolog; Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin [...] |
| ERCC6L2 protein network | https://string-db.org/network/9606.ENSP00000288985 | DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response |
| HPD protein network | https://string-db.org/network/9606.ENSP00000289004 | 4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family |
| RHPN1 protein network | https://string-db.org/network/9606.ENSP00000289013 | Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules (By similarity); PDZ [...] |
| FANCC protein network | https://string-db.org/network/9606.ENSP00000289081 | Fanconi anemia group C protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...] |
| MRAS protein network | https://string-db.org/network/9606.ENSP00000289104 | Ras-related protein M-Ras; May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway; Belongs to the smal [...] |
| ABHD3 protein network | https://string-db.org/network/9606.ENSP00000289119 | Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 [...] |
| PIK3CB protein network | https://string-db.org/network/9606.ENSP00000289153 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4 [...] |
| FAM46B protein network | https://string-db.org/network/9606.ENSP00000289166 | Putative nucleotidyltransferase FAM46B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase |
| ACTR1B protein network | https://string-db.org/network/9606.ENSP00000289228 | Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins |
| RHBDL2 protein network | https://string-db.org/network/9606.ENSP00000289248 | Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3; Rhomboid fam [...] |
| PCDHAC2 protein network | https://string-db.org/network/9606.ENSP00000289269 | Protocadherin alpha-C2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| PCDHA13 protein network | https://string-db.org/network/9606.ENSP00000289272 | Protocadherin alpha-13; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| HIST1H2BD protein network | https://string-db.org/network/9606.ENSP00000289316 | Histone H2B type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| MITD1 protein network | https://string-db.org/network/9606.ENSP00000289359 | MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex |
| BTN3A1 protein network | https://string-db.org/network/9606.ENSP00000289361 | Butyrophilin subfamily 3 member A1; Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and [...] |
| EIF5B protein network | https://string-db.org/network/9606.ENSP00000289371 | Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex [...] |
| TMSNB protein network | https://string-db.org/network/9606.ENSP00000289373 | Thymosin beta 15a; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); B [...] |
| CNOT11 protein network | https://string-db.org/network/9606.ENSP00000289382 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA d [...] |
| CATIP protein network | https://string-db.org/network/9606.ENSP00000289388 | Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization |
| ACSM3 protein network | https://string-db.org/network/9606.ENSP00000289416 | Acyl-coenzyme A synthetase ACSM3, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspon [...] |
| CD1A protein network | https://string-db.org/network/9606.ENSP00000289429 | T-cell surface glycoprotein CD1a; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells; C1-set dom [...] |
| HMHB1 protein network | https://string-db.org/network/9606.ENSP00000289448 | Minor histocompatibility protein HB-1; Precursor of the histocomplatibility antigen HB-1. More generally, minor histocomplatibility antigens (mHags) refer to immunogenic peptide which, when compl [...] |
| OR10K1 protein network | https://string-db.org/network/9606.ENSP00000289451 | Olfactory receptor 10K1; Odorant receptor; Olfactory receptors, family 10 |
| NCF1 protein network | https://string-db.org/network/9606.ENSP00000289473 | Neutrophil cytosol factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production) |
| ZFAND2B protein network | https://string-db.org/network/9606.ENSP00000289528 | Zinc finger AN1-type containing 2B |
| NPC1L1 protein network | https://string-db.org/network/9606.ENSP00000289547 | Niemann-Pick C1-like protein 1; Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct mol [...] |
| SLCO2B1 protein network | https://string-db.org/network/9606.ENSP00000289575 | Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, t [...] |
| PAGE5 protein network | https://string-db.org/network/9606.ENSP00000289619 | PAGE family member 5; Belongs to the GAGE family |
| PKD1L1 protein network | https://string-db.org/network/9606.ENSP00000289672 | Polycystic kidney disease protein 1-like 1; Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Fo [...] |
| SLAMF8 protein network | https://string-db.org/network/9606.ENSP00000289707 | SLAM family member 8; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor; CD molecules |
| CDH15 protein network | https://string-db.org/network/9606.ENSP00000289746 | Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| NBL1 protein network | https://string-db.org/network/9606.ENSP00000289749 | Neuroblastoma suppressor of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) o [...] |
| HTR6 protein network | https://string-db.org/network/9606.ENSP00000289753 | 5-hydroxytryptamine receptor 6; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...] |
| ZSCAN23 protein network | https://string-db.org/network/9606.ENSP00000289788 | Zinc finger and SCAN domain-containing protein 23; May be involved in transcriptional regulation; SCAN domain containing |
| SPATA2L protein network | https://string-db.org/network/9606.ENSP00000289805 | Spermatogenesis-associated protein 2-like protein; Spermatogenesis associated 2 like |
| SLC45A1 protein network | https://string-db.org/network/9606.ENSP00000289877 | Proton-associated sugar transporter A; Proton-associated glucose transporter in the brain; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family |
| FCER1G protein network | https://string-db.org/network/9606.ENSP00000289902 | High affinity immunoglobulin epsilon receptor subunit gamma; Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response [...] |
| FAM160B2 protein network | https://string-db.org/network/9606.ENSP00000289921 | Protein FAM160B2; Family with sequence similarity 160 member B2; Belongs to the UPF0518 family |
| SLC5A11 protein network | https://string-db.org/network/9606.ENSP00000289932 | Sodium/myo-inositol cotransporter 2; Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and a [...] |
| CHRNB3 protein network | https://string-db.org/network/9606.ENSP00000289957 | Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...] |
| ARHGAP17 protein network | https://string-db.org/network/9606.ENSP00000289968 | Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarit [...] |
| C8orf58 protein network | https://string-db.org/network/9606.ENSP00000289989 | Uncharacterized protein C8orf58; Chromosome 8 open reading frame 58 |
| WNT9B protein network | https://string-db.org/network/9606.ENSP00000290015 | Protein Wnt-9b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| CACHD1 protein network | https://string-db.org/network/9606.ENSP00000290039 | VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels |
| TMEM141 protein network | https://string-db.org/network/9606.ENSP00000290079 | Transmembrane protein 141 |
| CELA3A protein network | https://string-db.org/network/9606.ENSP00000290122 | Chymotrypsin-like elastase family member 3A; Efficient protease with alanine specificity but only little elastolytic activity |
| MIS18A protein network | https://string-db.org/network/9606.ENSP00000290130 | Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis |
| C21orf59 protein network | https://string-db.org/network/9606.ENSP00000290155 | UPF0769 protein C21orf59; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility [...] |
| KPNB1 protein network | https://string-db.org/network/9606.ENSP00000290158 | Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in c [...] |
| WNT4 protein network | https://string-db.org/network/9606.ENSP00000290167 | Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete re [...] |
| IL10RB protein network | https://string-db.org/network/9606.ENSP00000290200 | Interleukin-10 receptor subunit beta; Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor [...] |
| MRPL10 protein network | https://string-db.org/network/9606.ENSP00000290208 | Mitochondrial ribosomal protein L10; Belongs to the universal ribosomal protein uL10 family |
| SCRN2 protein network | https://string-db.org/network/9606.ENSP00000290216 | Secernin-2; Secernin 2; Belongs to the peptidase C69 family. Secernin subfamily |
| IFNGR2 protein network | https://string-db.org/network/9606.ENSP00000290219 | Interferon gamma receptor 2; Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required f [...] |
| NCOA5 protein network | https://string-db.org/network/9606.ENSP00000290231 | Nuclear receptor coactivator 5; Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently [...] |
| ELMO2 protein network | https://string-db.org/network/9606.ENSP00000290246 | Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...] |
| STC1 protein network | https://string-db.org/network/9606.ENSP00000290271 | Stanniocalcin-1; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia |
| ARAF protein network | https://string-db.org/network/9606.ENSP00000290277 | Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade; Belongs to the protein [...] |
| OGFR protein network | https://string-db.org/network/9606.ENSP00000290291 | Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met-enkephalin. Seems to be involved in growth regulation |
| PRAC1 protein network | https://string-db.org/network/9606.ENSP00000290294 | PRAC1 small nuclear protein |
| HOXB13 protein network | https://string-db.org/network/9606.ENSP00000290295 | Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| ATP5O protein network | https://string-db.org/network/9606.ENSP00000290299 | ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...] |
| KCNE2 protein network | https://string-db.org/network/9606.ENSP00000290310 | Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...] |
| CLIC6 protein network | https://string-db.org/network/9606.ENSP00000290332 | Chloride intracellular channel protein 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride [...] |
| IGF2BP1 protein network | https://string-db.org/network/9606.ENSP00000290341 | Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows m [...] |
| CBR1 protein network | https://string-db.org/network/9606.ENSP00000290349 | Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menad [...] |
| CBR3 protein network | https://string-db.org/network/9606.ENSP00000290354 | Carbonyl reductase [NADPH] 3; Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro); Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| CIART protein network | https://string-db.org/network/9606.ENSP00000290363 | Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptiona [...] |
| GJD2 protein network | https://string-db.org/network/9606.ENSP00000290374 | Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| ACTC1 protein network | https://string-db.org/network/9606.ENSP00000290378 | Actin, alpha cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the acti [...] |
| C2orf81 protein network | https://string-db.org/network/9606.ENSP00000290390 | Uncharacterized protein C2orf81; Chromosome 2 open reading frame 81 |
| SIM2 protein network | https://string-db.org/network/9606.ENSP00000290399 | Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development; B [...] |
| NPTN protein network | https://string-db.org/network/9606.ENSP00000290401 | Neuroplastin; Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate ne [...] |
| CCDC142 protein network | https://string-db.org/network/9606.ENSP00000290418 | Coiled-coil domain containing 142 |
| MCAT protein network | https://string-db.org/network/9606.ENSP00000290429 | Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondri [...] |
| PKD2L2 protein network | https://string-db.org/network/9606.ENSP00000290431 | Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization; Belongs to the polycystin family |
| GOLGA6A protein network | https://string-db.org/network/9606.ENSP00000290438 | Golgin A6 family member A; Belongs to the GOLGA6 family |
| PLA2G4D protein network | https://string-db.org/network/9606.ENSP00000290472 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. May have a substrate specificity for linoleic acid at t [...] |
| RFX5 protein network | https://string-db.org/network/9606.ENSP00000290524 | DNA-binding protein RFX5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters; Bel [...] |
| M1AP protein network | https://string-db.org/network/9606.ENSP00000290536 | Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis |
| PSMB4 protein network | https://string-db.org/network/9606.ENSP00000290541 | Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| BTG2 protein network | https://string-db.org/network/9606.ENSP00000290551 | Protein BTG2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent ma [...] |
| IRX6 protein network | https://string-db.org/network/9606.ENSP00000290552 | Iroquois-class homeodomain protein IRX-6; TALE class homeoboxes and pseudogenes |
| HK2 protein network | https://string-db.org/network/9606.ENSP00000290573 | Hexokinase-2; Hexokinase 2; Belongs to the hexokinase family |
| CELF3 protein network | https://string-db.org/network/9606.ENSP00000290583 | CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue- [...] |
| STARD9 protein network | https://string-db.org/network/9606.ENSP00000290607 | StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM); Kinesins |
| AMFR protein network | https://string-db.org/network/9606.ENSP00000290649 | E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Compone [...] |
| UBR1 protein network | https://string-db.org/network/9606.ENSP00000290650 | E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destab [...] |
| MED8 protein network | https://string-db.org/network/9606.ENSP00000290663 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| RGL4 protein network | https://string-db.org/network/9606.ENSP00000290691 | Ral-GDS-related protein; Ral guanine nucleotide dissociation stimulator like 4 |
| PGLYRP3 protein network | https://string-db.org/network/9606.ENSP00000290722 | Peptidoglycan recognition protein 3; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...] |
| ISL2 protein network | https://string-db.org/network/9606.ENSP00000290759 | Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways; LIM class home [...] |
| GSTT2B protein network | https://string-db.org/network/9606.ENSP00000290765 | Glutathione S-transferase theta-2B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity; Soluble glutathione S-tran [...] |
| CPNE2 protein network | https://string-db.org/network/9606.ENSP00000290776 | Copine-2; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties; Belongs to the [...] |
| TRMU protein network | https://string-db.org/network/9606.ENSP00000290846 | Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation o [...] |
| ACE protein network | https://string-db.org/network/9606.ENSP00000290866 | Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able t [...] |
| TEPP protein network | https://string-db.org/network/9606.ENSP00000290871 | Testis, prostate and placenta expressed |
| SHF protein network | https://string-db.org/network/9606.ENSP00000290894 | SH2 domain-containing adapter protein F; Adapter protein which may play a role in the regulation of apoptosis in response to PDGF; SH2 domain containing |
| CHCHD6 protein network | https://string-db.org/network/9606.ENSP00000290913 | MICOS complex subunit MIC25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| CTBP1 protein network | https://string-db.org/network/9606.ENSP00000290921 | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and [...] |
| ANKRD18B protein network | https://string-db.org/network/9606.ENSP00000290943 | Ankyrin repeat domain-containing protein 18B; Ankyrin repeat domain containing |
| ATP6V0D1 protein network | https://string-db.org/network/9606.ENSP00000290949 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryot [...] |
| AGRP protein network | https://string-db.org/network/9606.ENSP00000290953 | Agouti-related protein; Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antag [...] |
| ZFYVE28 protein network | https://string-db.org/network/9606.ENSP00000290974 | Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated; Be [...] |
| PIP protein network | https://string-db.org/network/9606.ENSP00000291009 | Prolactin induced protein; Belongs to the PIP family |
| PSKH1 protein network | https://string-db.org/network/9606.ENSP00000291041 | Serine/threonine-protein kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors [...] |
| ZNF235 protein network | https://string-db.org/network/9606.ENSP00000291182 | Zinc finger protein 235; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR3A3 protein network | https://string-db.org/network/9606.ENSP00000291231 | Olfactory receptor 3A3; Odorant receptor; Olfactory receptors, family 3 |
| TNFRSF13C protein network | https://string-db.org/network/9606.ENSP00000291232 | Tumor necrosis factor receptor superfamily member 13C; B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response; CD molecules |
| PTGIR protein network | https://string-db.org/network/9606.ENSP00000291294 | Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase |
| CALM3 protein network | https://string-db.org/network/9606.ENSP00000291295 | Calmodulin 3 (phosphorylase kinase, delta); Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to [...] |
| SSU72 protein network | https://string-db.org/network/9606.ENSP00000291386 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA proces [...] |
| TRIM62 protein network | https://string-db.org/network/9606.ENSP00000291416 | E3 ubiquitin-protein ligase TRIM62; E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2; Ring finger proteins |
| NR2F6 protein network | https://string-db.org/network/9606.ENSP00000291442 | Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5 [...] |
| CCDC58 protein network | https://string-db.org/network/9606.ENSP00000291458 | Coiled-coil domain containing 58; Belongs to the CCDC58 family |
| HAPLN4 protein network | https://string-db.org/network/9606.ENSP00000291481 | Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix; V-set domain containing |
| CILP2 protein network | https://string-db.org/network/9606.ENSP00000291495 | Cartilage intermediate layer protein 2; May play a role in cartilage scaffolding; Immunoglobulin like domain containing |
| TFF2 protein network | https://string-db.org/network/9606.ENSP00000291526 | Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel [...] |
| TFF1 protein network | https://string-db.org/network/9606.ENSP00000291527 | Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate cry [...] |
| TMPRSS3 protein network | https://string-db.org/network/9606.ENSP00000291532 | Transmembrane protease serine 3; Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is r [...] |
| RSPH1 protein network | https://string-db.org/network/9606.ENSP00000291536 | Radial spoke head 1 homolog; May play an important role in male meiosis (By similarity). It is necessary for proper building of the axonemal central pair and radial spokes |
| PDE9A protein network | https://string-db.org/network/9606.ENSP00000291539 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specif [...] |
| PKNOX1 protein network | https://string-db.org/network/9606.ENSP00000291547 | Homeobox protein PKNOX1; TALE class homeoboxes and pseudogenes |
| U2AFBP protein network | https://string-db.org/network/9606.ENSP00000291552 | U2 small nuclear RNA auxiliary factor 1; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions require [...] |
| HSPB4 protein network | https://string-db.org/network/9606.ENSP00000291554 | Crystallin, alpha A; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditi [...] |
| HSF2BP protein network | https://string-db.org/network/9606.ENSP00000291560 | Heat shock factor 2-binding protein; May be involved in modulating HSF2 activation in testis. Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cyt [...] |
| PDXK protein network | https://string-db.org/network/9606.ENSP00000291565 | Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family |
| CSTB protein network | https://string-db.org/network/9606.ENSP00000291568 | Cystatin-B; This is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B; Belongs to the cystatin family |
| TRAPPC10 protein network | https://string-db.org/network/9606.ENSP00000291574 | Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TMEM1 family |
| PWP2 protein network | https://string-db.org/network/9606.ENSP00000291576 | Periodic tryptophan protein 2 homolog; PWP2, small subunit processome component; UTPb subcomplex |
| C21orf33 protein network | https://string-db.org/network/9606.ENSP00000291577 | ES1 protein homolog, mitochondrial; Glutamine amidotransferase like class 1 domain containing |
| AIRE protein network | https://string-db.org/network/9606.ENSP00000291582 | Autoimmune regulator; Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonalit [...] |
| LRRC3 protein network | https://string-db.org/network/9606.ENSP00000291592 | Leucine-rich repeat-containing protein 3; Leucine rich repeat containing 3 |
| FAM207A protein network | https://string-db.org/network/9606.ENSP00000291634 | Protein FAM207A; Family with sequence similarity 207 member A |
| FTCD protein network | https://string-db.org/network/9606.ENSP00000291670 | Formimidoyltransferase-cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate poo [...] |
| SPATC1L protein network | https://string-db.org/network/9606.ENSP00000291672 | Speriolin-like protein; Spermatogenesis and centriole associated 1 like |
| C21orf58 protein network | https://string-db.org/network/9606.ENSP00000291691 | Uncharacterized protein C21orf58; Chromosome 21 open reading frame 58 |
| S100B protein network | https://string-db.org/network/9606.ENSP00000291700 | Protein S100-B; Weakly binds calcium but binds zinc very tightly- distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium i [...] |
| SIGLEC12 protein network | https://string-db.org/network/9606.ENSP00000291707 | Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sia [...] |
| CLDND2 protein network | https://string-db.org/network/9606.ENSP00000291715 | Claudin domain containing 2 |
| FCN2 protein network | https://string-db.org/network/9606.ENSP00000291744 | Ficolin-2; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils [...] |
| LILRA4 protein network | https://string-db.org/network/9606.ENSP00000291759 | Leukocyte immunoglobulin-like receptor subfamily A member 4; Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the product [...] |
| HIPK4 protein network | https://string-db.org/network/9606.ENSP00000291823 | Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of t [...] |
| SHKBP1 protein network | https://string-db.org/network/9606.ENSP00000291842 | SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits [...] |
| KIR3DL3 protein network | https://string-db.org/network/9606.ENSP00000291860 | Killer cell immunoglobulin-like receptor 3DL3; Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis; CD molecules |
| NCR1 protein network | https://string-db.org/network/9606.ENSP00000291890 | Natural cytotoxicity triggering receptor 1; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis |
| ZER1 protein network | https://string-db.org/network/9606.ENSP00000291900 | Protein zer-1 homolog; Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC; Armadillo-like helical domain containing |
| PKN3 protein network | https://string-db.org/network/9606.ENSP00000291906 | Serine/threonine-protein kinase N3; Contributes to invasiveness in malignant prostate cancer; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily |
| TMEM190 protein network | https://string-db.org/network/9606.ENSP00000291934 | Transmembrane protein 190 |
| NLRP8 protein network | https://string-db.org/network/9606.ENSP00000291971 | NACHT, LRR and PYD domains-containing protein 8; Involved in inflammation; NLR family |
| MED27 protein network | https://string-db.org/network/9606.ENSP00000292035 | Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| FXYD2 protein network | https://string-db.org/network/9606.ENSP00000292079 | Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase; Belongs [...] |
| TLCD1 protein network | https://string-db.org/network/9606.ENSP00000292090 | Calfacilitin; Calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CACNA1C/CaV1.2 channel. Regulation of intracellu [...] |
| TMEM199 protein network | https://string-db.org/network/9606.ENSP00000292114 | Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)-ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracel [...] |
| PSG6 protein network | https://string-db.org/network/9606.ENSP00000292125 | Pregnancy specific beta-1-glycoprotein 6 |
| PHLDB3 protein network | https://string-db.org/network/9606.ENSP00000292140 | Pleckstrin homology like domain family B member 3 |
| ETHE1 protein network | https://string-db.org/network/9606.ENSP00000292147 | Persulfide dioxygenase ETHE1, mitochondrial; Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized [...] |
| S100A1 protein network | https://string-db.org/network/9606.ENSP00000292169 | Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational [...] |
| CXCR5 protein network | https://string-db.org/network/9606.ENSP00000292174 | C-X-C chemokine receptor type 5; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into th [...] |
| FLAD1 protein network | https://string-db.org/network/9606.ENSP00000292180 | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 su [...] |
| UBE2Q1 protein network | https://string-db.org/network/9606.ENSP00000292211 | Ubiquitin-conjugating enzyme E2 Q1; Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell su [...] |
| ANO10 protein network | https://string-db.org/network/9606.ENSP00000292246 | Anoctamin-10; Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1; Belongs to the anoctamin family |
| CCR2 protein network | https://string-db.org/network/9606.ENSP00000292301 | C-C chemokine receptor type 2; Receptor for the CCL2, CCL7 and CCL13 chemokines. Receptor for the beta-defensin DEFB106A/DEFB106B. Transduces a signal by increasing intracellular calcium ion leve [...] |
| CCR5 protein network | https://string-db.org/network/9606.ENSP00000292303 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellula [...] |
| CCDC12 protein network | https://string-db.org/network/9606.ENSP00000292314 | Coiled-coil domain containing 12; Spliceosomal Bact complex |
| PPP1R35 protein network | https://string-db.org/network/9606.ENSP00000292330 | Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity; Protein phosphatase 1 regulatory subunits |
| RNF126 protein network | https://string-db.org/network/9606.ENSP00000292363 | E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked poly [...] |
| GPC2 protein network | https://string-db.org/network/9606.ENSP00000292377 | Glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Glypicans |
| DBN1 protein network | https://string-db.org/network/9606.ENSP00000292385 | Drebrin; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXC [...] |
| AZGP1 protein network | https://string-db.org/network/9606.ENSP00000292401 | Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids; Belongs to t [...] |
| FGFR4 protein network | https://string-db.org/network/9606.ENSP00000292408 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentia [...] |
| CYP11B1 protein network | https://string-db.org/network/9606.ENSP00000292427 | Cytochrome P450 11B1, mitochondrial; Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estr [...] |
| LY6K protein network | https://string-db.org/network/9606.ENSP00000292430 | Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida (By similarity). May play a role in cell growth; LY6/PLAU [...] |
| NACC1 protein network | https://string-db.org/network/9606.ENSP00000292431 | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Cont [...] |
| HK3 protein network | https://string-db.org/network/9606.ENSP00000292432 | Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) . Mediates the initial step of g [...] |
| ZSCAN21 protein network | https://string-db.org/network/9606.ENSP00000292450 | Zinc finger and SCAN domain-containing protein 21; Strong transcriptional activator; SCAN domain containing |
| ATP5J2 protein network | https://string-db.org/network/9606.ENSP00000292475 | ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...] |
| CPSF4 protein network | https://string-db.org/network/9606.ENSP00000292476 | Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...] |
| PTCD1 protein network | https://string-db.org/network/9606.ENSP00000292478 | Pentatricopeptide repeat-containing protein 1, mitochondrial; Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria-encode [...] |
| PTGER1 protein network | https://string-db.org/network/9606.ENSP00000292513 | Prostaglandin E2 receptor EP1 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messen [...] |
| LRRC14 protein network | https://string-db.org/network/9606.ENSP00000292524 | Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF- kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB; Belongs [...] |
| ZNF333 protein network | https://string-db.org/network/9606.ENSP00000292530 | Zinc finger protein 333; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PPP1R16A protein network | https://string-db.org/network/9606.ENSP00000292539 | Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates; Ankyrin repeat domain containing |
| ZNF251 protein network | https://string-db.org/network/9606.ENSP00000292562 | Zinc finger protein 251; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ALKBH4 protein network | https://string-db.org/network/9606.ENSP00000292566 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-process [...] |
| CCDC105 protein network | https://string-db.org/network/9606.ENSP00000292574 | Coiled-coil domain containing 105 |
| ZNF250 protein network | https://string-db.org/network/9606.ENSP00000292579 | Zinc finger protein 250; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| C5orf45 protein network | https://string-db.org/network/9606.ENSP00000292586 | MRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes [...] |
| LTC4S protein network | https://string-db.org/network/9606.ENSP00000292596 | Leukotriene C4 synthase; Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 |
| MAML1 protein network | https://string-db.org/network/9606.ENSP00000292599 | Mastermind-like protein 1; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnov [...] |
| POLR2J protein network | https://string-db.org/network/9606.ENSP00000292614 | DNA-directed RNA polymerase II subunit RPB11-a; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RN [...] |
| LRWD1 protein network | https://string-db.org/network/9606.ENSP00000292616 | Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replic [...] |
| SCGB3A1 protein network | https://string-db.org/network/9606.ENSP00000292641 | Secretoglobin family 3A member 1; Secreted cytokine-like protein. Inhibits cell growth in vitro; Belongs to the secretoglobin family. UGRP subfamily |
| CELF5 protein network | https://string-db.org/network/9606.ENSP00000292672 | CUGBP Elav-like family member 5; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissu [...] |
| YDJC protein network | https://string-db.org/network/9606.ENSP00000292778 | Carbohydrate deacetylase; Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides |
| CCDC116 protein network | https://string-db.org/network/9606.ENSP00000292779 | Coiled-coil domain containing 116 |
| DCUN1D1 protein network | https://string-db.org/network/9606.ENSP00000292782 | DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 [...] |
| AP2M1 protein network | https://string-db.org/network/9606.ENSP00000292807 | AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. [...] |
| PCYT1A protein network | https://string-db.org/network/9606.ENSP00000292823 | Choline-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family |
| ZNF585A protein network | https://string-db.org/network/9606.ENSP00000292841 | Zinc finger protein 585A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FBXO17 protein network | https://string-db.org/network/9606.ENSP00000292852 | F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modifi [...] |
| FBXO27 protein network | https://string-db.org/network/9606.ENSP00000292853 | F-box only protein 27; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modifi [...] |
| U2AF1L4 protein network | https://string-db.org/network/9606.ENSP00000292879 | Splicing factor U2AF 35 kDa subunit-like protein; U2 small nuclear RNA auxiliary factor 1 like 4; RNA binding motif containing |
| THAP8 protein network | https://string-db.org/network/9606.ENSP00000292894 | THAP domain containing 8 |
| COX7A1 protein network | https://string-db.org/network/9606.ENSP00000292907 | Cytochrome c oxidase subunit 7A1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| ZNF382 protein network | https://string-db.org/network/9606.ENSP00000292928 | Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| GRIN2C protein network | https://string-db.org/network/9606.ENSP00000293190 | Glutamate receptor ionotropic, NMDA 2C; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...] |
| ACOX1 protein network | https://string-db.org/network/9606.ENSP00000293217 | Peroxisomal acyl-coenzyme A oxidase 1; Catalyzes the desaturation of acyl-CoAs to 2-trans- enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases [...] |
| CYGB protein network | https://string-db.org/network/9606.ENSP00000293230 | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer |
| CABP5 protein network | https://string-db.org/network/9606.ENSP00000293255 | Calcium-binding protein 5; Inhibits calcium-dependent inactivation of L-type calcium channel and shifts voltage dependence of activation to more depolarized membrane potentials. Involved in the t [...] |
| TMEM143 protein network | https://string-db.org/network/9606.ENSP00000293261 | Transmembrane protein 143 |
| BAX protein network | https://string-db.org/network/9606.ENSP00000293288 | Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergo [...] |
| KLHL10 protein network | https://string-db.org/network/9606.ENSP00000293303 | Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target p [...] |
| STAT5B protein network | https://string-db.org/network/9606.ENSP00000293328 | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and ot [...] |
| HCRT protein network | https://string-db.org/network/9606.ENSP00000293330 | Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these compl [...] |
| ALDH16A1 protein network | https://string-db.org/network/9606.ENSP00000293350 | Aldehyde dehydrogenase 16 family member A1 |
| PSME3 protein network | https://string-db.org/network/9606.ENSP00000293362 | Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-ga [...] |
| NCKAP1L protein network | https://string-db.org/network/9606.ENSP00000293373 | Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythro [...] |
| ITGA5 protein network | https://string-db.org/network/9606.ENSP00000293379 | Integrin alpha-5; Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is [...] |
| NAGS protein network | https://string-db.org/network/9606.ENSP00000293404 | N-acetylglutamate synthase, mitochondrial; Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I [...] |
| IZUMO2 protein network | https://string-db.org/network/9606.ENSP00000293405 | Izumo sperm-egg fusion protein 2; IZUMO family member 2 |
| ASB16 protein network | https://string-db.org/network/9606.ENSP00000293414 | Ankyrin repeat and SOCS box protein 16; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| SHANK1 protein network | https://string-db.org/network/9606.ENSP00000293441 | SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membran [...] |
| FAM171A2 protein network | https://string-db.org/network/9606.ENSP00000293443 | Protein FAM171A2; Family with sequence similarity 171 member A2 |
| ZNF613 protein network | https://string-db.org/network/9606.ENSP00000293471 | Zinc finger protein 613; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SDR9C7 protein network | https://string-db.org/network/9606.ENSP00000293502 | Short-chain dehydrogenase/reductase family 9C member 7; Displays weak conversion of all-trans-retinal to all- trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activi [...] |
| WNT1 protein network | https://string-db.org/network/9606.ENSP00000293549 | Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional a [...] |
| AQP5 protein network | https://string-db.org/network/9606.ENSP00000293599 | Aquaporin-5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls [...] |
| C6orf136 protein network | https://string-db.org/network/9606.ENSP00000293604 | Uncharacterized protein C6orf136; Chromosome 6 open reading frame 136 |
| CELA1 protein network | https://string-db.org/network/9606.ENSP00000293636 | Chymotrypsin-like elastase family member 1; Acts upon elastin |
| GRASP protein network | https://string-db.org/network/9606.ENSP00000293662 | General receptor for phosphoinositides 1-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamat [...] |
| KRT83 protein network | https://string-db.org/network/9606.ENSP00000293670 | Keratin, type II cuticular Hb3; Keratins, type II |
| RAVER1 protein network | https://string-db.org/network/9606.ENSP00000293677 | Ribonucleoprotein PTB-binding 1; Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually excl [...] |
| SYCE2 protein network | https://string-db.org/network/9606.ENSP00000293695 | Synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...] |
| ZNF563 protein network | https://string-db.org/network/9606.ENSP00000293725 | Zinc finger protein 563; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| KRT72 protein network | https://string-db.org/network/9606.ENSP00000293745 | Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) |
| LEMD2 protein network | https://string-db.org/network/9606.ENSP00000293760 | LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope; LEM domain containing |
| ZNF653 protein network | https://string-db.org/network/9606.ENSP00000293771 | Zinc finger protein 653; Transcriptional repressor. May repress NR5A1, PPARG, NR1H3, NR4A2, ESR1 and NR3C1 transcriptional activity; Zinc fingers C2H2-type |
| MED11 protein network | https://string-db.org/network/9606.ENSP00000293777 | Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| CXCL16 protein network | https://string-db.org/network/9606.ENSP00000293778 | C-X-C motif chemokine 16; Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology [...] |
| CHRNE protein network | https://string-db.org/network/9606.ENSP00000293780 | Acetylcholine receptor subunit epsilon; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting c [...] |
| BCL6B protein network | https://string-db.org/network/9606.ENSP00000293805 | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. May function in a narrow stage or be related to some events in the early B- [...] |
| TNFSF12 protein network | https://string-db.org/network/9606.ENSP00000293825 | Tumor necrosis factor ligand superfamily member 12; Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiog [...] |
| TNFSF12-TNFSF13 protein network | https://string-db.org/network/9606.ENSP00000293826 | TNFSF12-TNFSF13 readthrough; Belongs to the tumor necrosis factor family |
| FGF11 protein network | https://string-db.org/network/9606.ENSP00000293829 | Fibroblast growth factor 11; Probably involved in nervous system development and function |
| EIF4A1 protein network | https://string-db.org/network/9606.ENSP00000293831 | Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current mode [...] |
| CCDC42 protein network | https://string-db.org/network/9606.ENSP00000293845 | Coiled-coil domain-containing protein 42; Required for sperm development |
| PRSS33 protein network | https://string-db.org/network/9606.ENSP00000293851 | Serine protease 33; Serine protease that has amidolytic activity, cleaving its substrates before Arg residues |
| POLR3K protein network | https://string-db.org/network/9606.ENSP00000293860 | DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA [...] |
| LUC7L protein network | https://string-db.org/network/9606.ENSP00000293872 | Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain; Belongs to the Luc7 family |
| WDR90 protein network | https://string-db.org/network/9606.ENSP00000293879 | WD repeat-containing protein 90; WD repeat domain containing |
| WDR24 protein network | https://string-db.org/network/9606.ENSP00000293883 | GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC [...] |
| CCDC78 protein network | https://string-db.org/network/9606.ENSP00000293889 | Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles [...] |
| SOX8 protein network | https://string-db.org/network/9606.ENSP00000293894 | Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3' (By [...] |
| SSTR5 protein network | https://string-db.org/network/9606.ENSP00000293897 | Somatostatin receptor type 5; Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Incr [...] |
| PTX4 protein network | https://string-db.org/network/9606.ENSP00000293922 | Pentraxin-4; Long pentraxins |
| TBC1D24 protein network | https://string-db.org/network/9606.ENSP00000293970 | TBC1 domain family member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 functi [...] |
| NTN3 protein network | https://string-db.org/network/9606.ENSP00000293973 | Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons |
| SLX4 protein network | https://string-db.org/network/9606.ENSP00000294008 | Structure-specific endonuclease subunit SLX4; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protec [...] |
| ADCY9 protein network | https://string-db.org/network/9606.ENSP00000294016 | Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein- coupled receptors. Contributes to signaling cascades [...] |
| CLPB protein network | https://string-db.org/network/9606.ENSP00000294053 | Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; AAA ATPases |
| NEU3 protein network | https://string-db.org/network/9606.ENSP00000294064 | Sialidase-3; Plays a role in modulating the ganglioside content of the lipid bilayer at the level of membrane-bound sialyl glycoconjugates; Belongs to the glycosyl hydrolase 33 family |
| MAP4K2 protein network | https://string-db.org/network/9606.ENSP00000294066 | Mitogen-activated protein kinase kinase kinase kinase 2; Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase [...] |
| GNG3 protein network | https://string-db.org/network/9606.ENSP00000294117 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| UBXN1 protein network | https://string-db.org/network/9606.ENSP00000294119 | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Follo [...] |
| NCKIPSD protein network | https://string-db.org/network/9606.ENSP00000294129 | NCK-interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarit [...] |
| TAF6L protein network | https://string-db.org/network/9606.ENSP00000294168 | TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating hi [...] |
| STX5 protein network | https://string-db.org/network/9606.ENSP00000294179 | Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked [...] |
| C11orf84 protein network | https://string-db.org/network/9606.ENSP00000294244 | SPIN1-docking protein; Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-reg [...] |
| ZFPL1 protein network | https://string-db.org/network/9606.ENSP00000294258 | Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with [...] |
| CABP2 protein network | https://string-db.org/network/9606.ENSP00000294288 | Calcium binding protein 2; EF-hand domain containing |
| LRP5 protein network | https://string-db.org/network/9606.ENSP00000294304 | Low-density lipoprotein receptor-related protein 5; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into [...] |
| TPCN2 protein network | https://string-db.org/network/9606.ENSP00000294309 | Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal [...] |
| FGF19 protein network | https://string-db.org/network/9606.ENSP00000294312 | Fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stim [...] |
| PDZK1IP1 protein network | https://string-db.org/network/9606.ENSP00000294338 | PDZK1-interacting protein 1; May play an important role in tumor biology |
| TAL1 protein network | https://string-db.org/network/9606.ENSP00000294339 | T-cell acute lymphocytic leukemia protein 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of [...] |
| ZYG11B protein network | https://string-db.org/network/9606.ENSP00000294353 | Protein zyg-11 homolog B; Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC; Armadillo-like helical domain containing |
| C1orf123 protein network | https://string-db.org/network/9606.ENSP00000294360 | UPF0587 protein C1orf123; Chromosome 1 open reading frame 123; Belongs to the UPF0587 family |
| USP24 protein network | https://string-db.org/network/9606.ENSP00000294383 | Ubiquitin carboxyl-terminal hydrolase 24; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation [...] |
| GMEB1 protein network | https://string-db.org/network/9606.ENSP00000294409 | Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increas [...] |
| RHCE protein network | https://string-db.org/network/9606.ENSP00000294413 | Blood group Rh(CE) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane; Blood group antigens |
| RBP7 protein network | https://string-db.org/network/9606.ENSP00000294435 | Retinoid-binding protein 7; Intracellular transport of retinol; Fatty acid binding protein family |
| SLC25A34 protein network | https://string-db.org/network/9606.ENSP00000294454 | Solute carrier family 25 member 34 |
| PTCHD2 protein network | https://string-db.org/network/9606.ENSP00000294484 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid [...] |
| DRAXIN protein network | https://string-db.org/network/9606.ENSP00000294485 | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during developm [...] |
| PDPN protein network | https://string-db.org/network/9606.ENSP00000294489 | Podoplanin; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering [...] |
| LAPTM5 protein network | https://string-db.org/network/9606.ENSP00000294507 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family |
| AZIN2 protein network | https://string-db.org/network/9606.ENSP00000294517 | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that cou [...] |
| TMCO4 protein network | https://string-db.org/network/9606.ENSP00000294543 | Transmembrane and coiled-coil domains 4; Belongs to the TMCO4 family |
| CCDC27 protein network | https://string-db.org/network/9606.ENSP00000294600 | Coiled-coil domain containing 27 |
| DOCK6 protein network | https://string-db.org/network/9606.ENSP00000294618 | Dedicator of cytokinesis protein 6; Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By [...] |
| LHX8 protein network | https://string-db.org/network/9606.ENSP00000294638 | LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells; LIM class homeoboxes |
| WDR63 protein network | https://string-db.org/network/9606.ENSP00000294664 | WD repeat-containing protein 63; WD repeat domain containing |
| GBP7 protein network | https://string-db.org/network/9606.ENSP00000294671 | Guanylate-binding protein 7; Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host [...] |
| AGL protein network | https://string-db.org/network/9606.ENSP00000294724 | Glycogen debranching enzyme; Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4- alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6- glucosidase in glycogen degradation; Belongs to t [...] |
| KCNT2 protein network | https://string-db.org/network/9606.ENSP00000294725 | Potassium channel subfamily T member 2; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride leve [...] |
| VCAM1 protein network | https://string-db.org/network/9606.ENSP00000294728 | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocyte [...] |
| ZNF281 protein network | https://string-db.org/network/9606.ENSP00000294740 | Zinc finger protein 281; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepres [...] |
| ARPC5 protein network | https://string-db.org/network/9606.ENSP00000294742 | Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promot [...] |
| ZNF496 protein network | https://string-db.org/network/9606.ENSP00000294753 | Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| NCSTN protein network | https://string-db.org/network/9606.ENSP00000294785 | Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amylo [...] |
| C1orf74 protein network | https://string-db.org/network/9606.ENSP00000294811 | UPF0739 protein C1orf74; Chromosome 1 open reading frame 74; Belongs to the UPF0739 family |
| LRRC52 protein network | https://string-db.org/network/9606.ENSP00000294818 | Leucine-rich repeat-containing protein 52; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...] |
| FAM71A protein network | https://string-db.org/network/9606.ENSP00000294829 | Protein FAM71A; Family with sequence similarity 71 member A; Belongs to the FAM71 family |
| C1orf115 protein network | https://string-db.org/network/9606.ENSP00000294889 | Uncharacterized protein C1orf115; Chromosome 1 open reading frame 115 |
| RBMS1 protein network | https://string-db.org/network/9606.ENSP00000294904 | RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif [...] |
| PPP1R21 protein network | https://string-db.org/network/9606.ENSP00000294952 | Protein phosphatase 1 regulatory subunit 21 |
| LHCGR protein network | https://string-db.org/network/9606.ENSP00000294954 | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Glycoprot [...] |
| PKDCC protein network | https://string-db.org/network/9606.ENSP00000294964 | Extracellular tyrosine-protein kinase PKDCC; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is es [...] |
| HAAO protein network | https://string-db.org/network/9606.ENSP00000294973 | 3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belon [...] |
| CAPN2 protein network | https://string-db.org/network/9606.ENSP00000295006 | Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteoly [...] |
| C1orf145 protein network | https://string-db.org/network/9606.ENSP00000295012 | Uncharacterized protein OBSCN-AS1; Chromosome 1 open reading frame 145 |
| REL protein network | https://string-db.org/network/9606.ENSP00000295025 | Proto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is i [...] |
| PEX13 protein network | https://string-db.org/network/9606.ENSP00000295030 | Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10 [...] |
| RFTN2 protein network | https://string-db.org/network/9606.ENSP00000295049 | Raftlin-2; Raftlin family member 2; Belongs to the raftlin family |
| SPRTN protein network | https://string-db.org/network/9606.ENSP00000295050 | SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion [...] |
| CAPN13 protein network | https://string-db.org/network/9606.ENSP00000295055 | Calpain-13; Probable non-lysosomal thiol-protease; Calpains |
| LRRTM1 protein network | https://string-db.org/network/9606.ENSP00000295057 | Leucine-rich repeat transmembrane neuronal protein 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level; Belo [...] |
| MEMO1 protein network | https://string-db.org/network/9606.ENSP00000295065 | Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays [...] |
| C2orf47 protein network | https://string-db.org/network/9606.ENSP00000295079 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor p [...] |
| KCNF1 protein network | https://string-db.org/network/9606.ENSP00000295082 | Potassium voltage-gated channel subfamily F member 1; Putative voltage-gated potassium channel; Belongs to the potassium channel family. F (TC 1.A.1.2) subfamily. Kv5.1/KCNF1 sub-subfamily |
| PQLC3 protein network | https://string-db.org/network/9606.ENSP00000295083 | PQ-loop repeat-containing protein 3; PQ loop repeat containing 3 |
| ARL5A protein network | https://string-db.org/network/9606.ENSP00000295087 | ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity; ARF GTPase family |
| FAM84A protein network | https://string-db.org/network/9606.ENSP00000295092 | Protein FAM84A; Family with sequence similarity 84 member A |
| ARHGAP15 protein network | https://string-db.org/network/9606.ENSP00000295095 | Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in a [...] |
| KCNJ3 protein network | https://string-db.org/network/9606.ENSP00000295101 | G protein-activated inward rectifier potassium channel 1; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow [...] |
| NEUROD1 protein network | https://string-db.org/network/9606.ENSP00000295108 | Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associ [...] |
| FRZB protein network | https://string-db.org/network/9606.ENSP00000295113 | Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...] |
| NUP35 protein network | https://string-db.org/network/9606.ENSP00000295119 | Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs). Can play the role of both NPC structural components [...] |
| WDR92 protein network | https://string-db.org/network/9606.ENSP00000295121 | Uncharacterized protein DKFZp434B156; Seems to act as a modulator of apoptosis; WD repeat domain containing |
| CCDC138 protein network | https://string-db.org/network/9606.ENSP00000295124 | Coiled-coil domain containing 138 |
| ZSWIM2 protein network | https://string-db.org/network/9606.ENSP00000295131 | E3 ubiquitin-protein ligase ZSWIM2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 [...] |
| C2orf44 protein network | https://string-db.org/network/9606.ENSP00000295148 | WD repeat and coiled-coil-containing protein; Chromosome 2 open reading frame 44 |
| FAM228A protein network | https://string-db.org/network/9606.ENSP00000295150 | Protein FAM228A; Family with sequence similarity 228 member A; Belongs to the FAM228 family |
| CCDC74A protein network | https://string-db.org/network/9606.ENSP00000295171 | Coiled-coil domain containing 74A |
| SLC16A14 protein network | https://string-db.org/network/9606.ENSP00000295190 | Monocarboxylate transporter 14; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers |
| TEKT4 protein network | https://string-db.org/network/9606.ENSP00000295201 | Tektin-4; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity); Tektins |
| EN1 protein network | https://string-db.org/network/9606.ENSP00000295206 | Homeobox protein engrailed-1; NKL subclass homeoboxes and pseudogenes |
| ZNF514 protein network | https://string-db.org/network/9606.ENSP00000295208 | Zinc finger protein 514; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SPATA18 protein network | https://string-db.org/network/9606.ENSP00000295213 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochond [...] |
| KCNIP3 protein network | https://string-db.org/network/9606.ENSP00000295225 | Calsenilin; Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding [...] |
| CCDC140 protein network | https://string-db.org/network/9606.ENSP00000295226 | Coiled-coil domain containing 140 |
| INHBB protein network | https://string-db.org/network/9606.ENSP00000295228 | Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...] |
| BBS5 protein network | https://string-db.org/network/9606.ENSP00000295240 | Bardet-Biedl syndrome 5 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...] |
| HPGDS protein network | https://string-db.org/network/9606.ENSP00000295256 | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhi [...] |
| PDHA2 protein network | https://string-db.org/network/9606.ENSP00000295266 | Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), an [...] |
| STPG2 protein network | https://string-db.org/network/9606.ENSP00000295268 | Sperm-tail PG-rich repeat-containing protein 2; Sperm tail PG-rich repeat containing 2 |
| SLC9A4 protein network | https://string-db.org/network/9606.ENSP00000295269 | Sodium/hydrogen exchanger 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| C1QTNF7 protein network | https://string-db.org/network/9606.ENSP00000295297 | Complement C1q tumor necrosis factor-related protein 7; C1q and TNF related 7 |
| CHAC2 protein network | https://string-db.org/network/9606.ENSP00000295304 | Glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamm [...] |
| TMOD4 protein network | https://string-db.org/network/9606.ENSP00000295314 | Tropomodulin-4; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...] |
| RNF149 protein network | https://string-db.org/network/9606.ENSP00000295317 | E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation; Ring finger proteins |
| IWS1 protein network | https://string-db.org/network/9606.ENSP00000295321 | Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA [...] |
| CDC42EP3 protein network | https://string-db.org/network/9606.ENSP00000295324 | Cdc42 effector protein 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...] |
| BMP10 protein network | https://string-db.org/network/9606.ENSP00000295379 | Bone morphogenetic protein 10; Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KI [...] |
| TGFA protein network | https://string-db.org/network/9606.ENSP00000295400 | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent c [...] |
| MERTK protein network | https://string-db.org/network/9606.ENSP00000295408 | Tyrosine-protein kinase Mer; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. [...] |
| GNPDA2 protein network | https://string-db.org/network/9606.ENSP00000295448 | Glucosamine-6-phosphate deaminase 2 |
| GABRG1 protein network | https://string-db.org/network/9606.ENSP00000295452 | Gamma-aminobutyric acid receptor subunit gamma-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| ALPPL2 protein network | https://string-db.org/network/9606.ENSP00000295453 | Alkaline phosphatase, placental like 2 |
| GABRB1 protein network | https://string-db.org/network/9606.ENSP00000295454 | Gamma-aminobutyric acid receptor subunit beta-1; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine re [...] |
| NIPAL1 protein network | https://string-db.org/network/9606.ENSP00000295461 | Magnesium transporter NIPA3; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+), Cu(2+) and Co(2+) but to a much less extent than Mg(2+ [...] |
| ALPI protein network | https://string-db.org/network/9606.ENSP00000295463 | Alkaline phosphatase, intestinal |
| HELQ protein network | https://string-db.org/network/9606.ENSP00000295488 | Helicase POLQ-like; Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross- links and double-strand break (DSB) resistance. Participates in FANCD2-med [...] |
| MRPS18C protein network | https://string-db.org/network/9606.ENSP00000295491 | Mitochondrial ribosomal protein S18C |
| CLDN1 protein network | https://string-db.org/network/9606.ENSP00000295522 | Claudin-1; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the forma [...] |
| DCST1 protein network | https://string-db.org/network/9606.ENSP00000295542 | E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'- linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I [...] |
| COL6A3 protein network | https://string-db.org/network/9606.ENSP00000295550 | Collagen alpha-3(VI) chain; Collagen VI acts as a cell-binding protein; Collagens |
| FAM19A4 protein network | https://string-db.org/network/9606.ENSP00000295569 | Protein FAM19A4; Family with sequence similarity 19 member A4, C-C motif chemokine like |
| POGLUT1 protein network | https://string-db.org/network/9606.ENSP00000295588 | Protein O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in [...] |
| CCKAR protein network | https://string-db.org/network/9606.ENSP00000295589 | Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher a [...] |
| MITF protein network | https://string-db.org/network/9606.ENSP00000295600 | Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-bo [...] |
| PROK2 protein network | https://string-db.org/network/9606.ENSP00000295619 | Prokineticin-2; May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize outpu [...] |
| C3orf30 protein network | https://string-db.org/network/9606.ENSP00000295622 | Uncharacterized protein C3orf30; Chromosome 3 open reading frame 30 |
| LRRC58 protein network | https://string-db.org/network/9606.ENSP00000295628 | Leucine-rich repeat-containing protein 58; Leucine rich repeat containing 58 |
| FSTL1 protein network | https://string-db.org/network/9606.ENSP00000295633 | Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity); SPARC family |
| RNPEP protein network | https://string-db.org/network/9606.ENSP00000295640 | Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin a [...] |
| STK11IP protein network | https://string-db.org/network/9606.ENSP00000295641 | Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization |
| PDCL2 protein network | https://string-db.org/network/9606.ENSP00000295645 | Phosducin-like protein 2; May play a role in germ cell maturation |
| IGFBP7 protein network | https://string-db.org/network/9606.ENSP00000295666 | Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion; I-set domain containing |
| KRTCAP2 protein network | https://string-db.org/network/9606.ENSP00000295682 | Keratinocyte-associated protein 2; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked [...] |
| CXCR1 protein network | https://string-db.org/network/9606.ENSP00000295683 | C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is [...] |
| ARPC2 protein network | https://string-db.org/network/9606.ENSP00000295685 | Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nuc [...] |
| CCT3 protein network | https://string-db.org/network/9606.ENSP00000295688 | T-complex protein 1 subunit gamma; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex in [...] |
| SSR2 protein network | https://string-db.org/network/9606.ENSP00000295702 | Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Be [...] |
| RNF25 protein network | https://string-db.org/network/9606.ENSP00000295704 | E3 ubiquitin-protein ligase RNF25; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF [...] |
| STK36 protein network | https://string-db.org/network/9606.ENSP00000295709 | Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Cont [...] |
| PTPRN protein network | https://string-db.org/network/9606.ENSP00000295718 | Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancr [...] |
| FEV protein network | https://string-db.org/network/9606.ENSP00000295727 | Protein FEV; Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the centr [...] |
| CRYBA2 protein network | https://string-db.org/network/9606.ENSP00000295728 | Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens |
| IHH protein network | https://string-db.org/network/9606.ENSP00000295731 | Indian hedgehog protein; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened [...] |
| SLC4A7 protein network | https://string-db.org/network/9606.ENSP00000295736 | Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarb [...] |
| KIAA1524 protein network | https://string-db.org/network/9606.ENSP00000295746 | Protein CIP2A; Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation |
| RETNLB protein network | https://string-db.org/network/9606.ENSP00000295755 | Resistin-like beta; Probable hormone; Belongs to the resistin/FIZZ family |
| TRAT1 protein network | https://string-db.org/network/9606.ENSP00000295756 | T-cell receptor-associated transmembrane adapter 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells |
| HDAC11 protein network | https://string-db.org/network/9606.ENSP00000295757 | Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic re [...] |
| GLB1L protein network | https://string-db.org/network/9606.ENSP00000295759 | Beta-galactosidase-1-like protein; Probable glycosyl hydrolase |
| CHCHD4 protein network | https://string-db.org/network/9606.ENSP00000295767 | Mitochondrial intermembrane space import and assembly protein 40; Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1. Required for [...] |
| STT3B protein network | https://string-db.org/network/9606.ENSP00000295770 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose ol [...] |
| SERPINI1 protein network | https://string-db.org/network/9606.ENSP00000295777 | Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for [...] |
| PRKCI protein network | https://string-db.org/network/9606.ENSP00000295797 | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B acti [...] |
| RETSAT protein network | https://string-db.org/network/9606.ENSP00000295802 | All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any activity toward all-trans-retinoic acid, nor 9-cis, 11-ci [...] |
| EIF5A2 protein network | https://string-db.org/network/9606.ENSP00000295822 | Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of deca [...] |
| EFHB protein network | https://string-db.org/network/9606.ENSP00000295824 | EF-hand domain family member B; Cilia and flagella associated |
| FABP1 protein network | https://string-db.org/network/9606.ENSP00000295834 | Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, a [...] |
| ABI2 protein network | https://string-db.org/network/9606.ENSP00000295851 | Abl interactor 2; May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia f [...] |
| SPICE1 protein network | https://string-db.org/network/9606.ENSP00000295872 | Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis |
| KIAA1407 protein network | https://string-db.org/network/9606.ENSP00000295878 | Coiled-coil domain-containing protein 191; KIAA1407 |
| NKX6-1 protein network | https://string-db.org/network/9606.ENSP00000295886 | Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta ce [...] |
| CDS1 protein network | https://string-db.org/network/9606.ENSP00000295887 | Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression [...] |
| WDFY3 protein network | https://string-db.org/network/9606.ENSP00000295888 | WD repeat and FYVE domain-containing protein 3; Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core au [...] |
| C3orf49 protein network | https://string-db.org/network/9606.ENSP00000295896 | Putative uncharacterized protein C3orf49; Chromosome 3 open reading frame 49 |
| ALB protein network | https://string-db.org/network/9606.ENSP00000295897 | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulati [...] |
| THOC7 protein network | https://string-db.org/network/9606.ENSP00000295899 | THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, proc [...] |
| PRICKLE2 protein network | https://string-db.org/network/9606.ENSP00000295902 | Prickle planar cell polarity protein 2; LIM domain containing |
| ERICH6 protein network | https://string-db.org/network/9606.ENSP00000295910 | Glutamate-rich protein 6; Glutamate rich 6 |
| CCNL1 protein network | https://string-db.org/network/9606.ENSP00000295926 | Cyclin-L1; Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of R [...] |
| PTX3 protein network | https://string-db.org/network/9606.ENSP00000295927 | Pentraxin-related protein PTX3; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility; Long pentrax [...] |
| HESX1 protein network | https://string-db.org/network/9606.ENSP00000295934 | Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcripti [...] |
| SLMAP protein network | https://string-db.org/network/9606.ENSP00000295951 | Sarcolemmal membrane-associated protein; May play a role during myoblast fusion; STRIPAK complex |
| SMIM14 protein network | https://string-db.org/network/9606.ENSP00000295958 | Small integral membrane protein 14 |
| C3orf67 protein network | https://string-db.org/network/9606.ENSP00000295966 | Uncharacterized protein C3orf67; Chromosome 3 open reading frame 67 |
| IL17RC protein network | https://string-db.org/network/9606.ENSP00000295981 | Interleukin-17 receptor C; Isoform 8: Receptor for both IL17A and IL17F; Interleukin receptors |
| SYN1 protein network | https://string-db.org/network/9606.ENSP00000295987 | Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS [...] |
| PCOLCE2 protein network | https://string-db.org/network/9606.ENSP00000295992 | Procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1 |
| MTMR14 protein network | https://string-db.org/network/9606.ENSP00000296003 | Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIn [...] |
| TTC14 protein network | https://string-db.org/network/9606.ENSP00000296015 | Belongs to the TTC14 family |
| CXCL3 protein network | https://string-db.org/network/9606.ENSP00000296026 | C-X-C motif chemokine 3; Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fas [...] |
| CXCL5 protein network | https://string-db.org/network/9606.ENSP00000296027 | C-X-C motif chemokine 5; Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes; Chemokine ligands |
| PPBP protein network | https://string-db.org/network/9606.ENSP00000296028 | Platelet basic protein; LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosamin [...] |
| PF4 protein network | https://string-db.org/network/9606.ENSP00000296029 | Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the [...] |
| SHROOM3 protein network | https://string-db.org/network/9606.ENSP00000296043 | Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and [...] |
| CPA3 protein network | https://string-db.org/network/9606.ENSP00000296046 | M14 carboxypeptidases |
| HPS3 protein network | https://string-db.org/network/9606.ENSP00000296051 | Hermansky-Pudlak syndrome 3 protein; Involved in early stages of melanosome biogenesis and maturation; Biogenesis of lysosomal organelles complex 2 |
| TM4SF18 protein network | https://string-db.org/network/9606.ENSP00000296059 | Transmembrane 4 L six family member 18 |
| SNRK protein network | https://string-db.org/network/9606.ENSP00000296088 | SNF-related serine/threonine-protein kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis; Belongs to the protein kinase superf [...] |
| ZNF502 protein network | https://string-db.org/network/9606.ENSP00000296091 | Zinc finger protein 502; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TCF23 protein network | https://string-db.org/network/9606.ENSP00000296096 | Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodim [...] |
| DNAJC5G protein network | https://string-db.org/network/9606.ENSP00000296097 | DnaJ heat shock protein family member C5 gamma |
| TRIM54 protein network | https://string-db.org/network/9606.ENSP00000296098 | Tripartite motif containing 54; Ring finger proteins |
| UCN protein network | https://string-db.org/network/9606.ENSP00000296099 | Urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Plays a role in the establishment [...] |
| MRPL33 protein network | https://string-db.org/network/9606.ENSP00000296102 | Mitochondrial ribosomal protein L33 |
| KIAA1143 protein network | https://string-db.org/network/9606.ENSP00000296121 | Uncharacterized protein KIAA1143; KIAA1143 |
| TGM4 protein network | https://string-db.org/network/9606.ENSP00000296125 | Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins i [...] |
| ZDHHC3 protein network | https://string-db.org/network/9606.ENSP00000296127 | Palmitoyltransferase ZDHHC3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/ [...] |
| CDCP1 protein network | https://string-db.org/network/9606.ENSP00000296129 | CUB domain-containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiat [...] |
| CLEC3B protein network | https://string-db.org/network/9606.ENSP00000296130 | Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis; C-type lectin domain containing |
| LZTFL1 protein network | https://string-db.org/network/9606.ENSP00000296135 | Leucine zipper transcription factor-like protein 1; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the [...] |
| FYCO1 protein network | https://string-db.org/network/9606.ENSP00000296137 | FYVE and coiled-coil domain-containing protein 1; May mediate microtubule plus end-directed vesicle transport; GOLD domain containing |
| CCR1 protein network | https://string-db.org/network/9606.ENSP00000296140 | C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a [...] |
| RTP3 protein network | https://string-db.org/network/9606.ENSP00000296142 | Receptor-transporting protein 3; Promotes functional cell surface expression of the bitter taste receptors TAS2R16 and TAS2R43; Belongs to the TMEM7 family |
| TDGF1 protein network | https://string-db.org/network/9606.ENSP00000296145 | Teratocarcinoma-derived growth factor 1; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modul [...] |
| ELP6 protein network | https://string-db.org/network/9606.ENSP00000296149 | Elongator complex protein 6; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involve [...] |
| DTX3L protein network | https://string-db.org/network/9606.ENSP00000296161 | E3 ubiquitin-protein ligase DTX3L; E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral resp [...] |
| ITGB5 protein network | https://string-db.org/network/9606.ENSP00000296181 | Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand |
| SNIP1 protein network | https://string-db.org/network/9606.ENSP00000296215 | Smad nuclear-interacting protein 1; Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/ [...] |
| DNALI1 protein network | https://string-db.org/network/9606.ENSP00000296218 | Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family |
| OSBPL11 protein network | https://string-db.org/network/9606.ENSP00000296220 | Oxysterol-binding protein-related protein 11; Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage [...] |
| KLF15 protein network | https://string-db.org/network/9606.ENSP00000296233 | Krueppel-like factor 15; Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By sim [...] |
| CAMK2N2 protein network | https://string-db.org/network/9606.ENSP00000296238 | Calcium/calmodulin-dependent protein kinase II inhibitor 2; Potent and specific cellular inhibitor of CaM-kinase II (CAMK2). Traps Ca(2+)/calmodulin on CAMK2. May play an important role in the re [...] |
| LIPH protein network | https://string-db.org/network/9606.ENSP00000296252 | Lipase member H; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholi [...] |
| RPN1 protein network | https://string-db.org/network/9606.ENSP00000296255 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligos [...] |
| SENP2 protein network | https://string-db.org/network/9606.ENSP00000296257 | Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ub [...] |
| IFT122 protein network | https://string-db.org/network/9606.ENSP00000296266 | Intraflagellar transport protein 122 homolog; Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (B [...] |
| RHO protein network | https://string-db.org/network/9606.ENSP00000296271 | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retina [...] |
| RPL39L protein network | https://string-db.org/network/9606.ENSP00000296277 | Ribosomal protein L39 like; Belongs to the eukaryotic ribosomal protein eL39 family |
| MASP1 protein network | https://string-db.org/network/9606.ENSP00000296280 | Mannan binding lectin serine peptidase 1 |
| RFT1 protein network | https://string-db.org/network/9606.ENSP00000296292 | Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmi [...] |
| IL17RD protein network | https://string-db.org/network/9606.ENSP00000296318 | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuc [...] |
| ZDHHC19 protein network | https://string-db.org/network/9606.ENSP00000296326 | Probable palmitoyltransferase ZDHHC19; Zinc finger DHHC-type containing 19; Belongs to the DHHC palmitoyltransferase family |
| SLC51A protein network | https://string-db.org/network/9606.ENSP00000296327 | Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export [...] |
| UBXN7 protein network | https://string-db.org/network/9606.ENSP00000296328 | UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitinati [...] |
| PIGX protein network | https://string-db.org/network/9606.ENSP00000296333 | Phosphatidylinositol-glycan biosynthesis class X protein; Essential component of glycosylphosphatidylinositol- mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor [...] |
| KIAA0226 protein network | https://string-db.org/network/9606.ENSP00000296343 | Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophag [...] |
| MFI2 protein network | https://string-db.org/network/9606.ENSP00000296350 | Melanotransferrin; Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc |
| OTOP1 protein network | https://string-db.org/network/9606.ENSP00000296358 | Otopetrin-1; Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By simil [...] |
| S100P protein network | https://string-db.org/network/9606.ENSP00000296370 | Protein S100-P; May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, an [...] |
| CLDN19 protein network | https://string-db.org/network/9606.ENSP00000296387 | Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| METAP1 protein network | https://string-db.org/network/9606.ENSP00000296411 | Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence [...] |
| ADH5 protein network | https://string-db.org/network/9606.ENSP00000296412 | Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxym [...] |
| H2AFZ protein network | https://string-db.org/network/9606.ENSP00000296417 | Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machiner [...] |
| EMCN protein network | https://string-db.org/network/9606.ENSP00000296420 | Endomucin; Endothelial sialomucin, also called endomucin or mucin- like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells an [...] |
| SLC9B1 protein network | https://string-db.org/network/9606.ENSP00000296422 | Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility; Belongs to the monovalent cati [...] |
| BDH2 protein network | https://string-db.org/network/9606.ENSP00000296424 | 3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial entero [...] |
| CAMP protein network | https://string-db.org/network/9606.ENSP00000296435 | Cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity; Endogenous ligands |
| FBXW12 protein network | https://string-db.org/network/9606.ENSP00000296438 | F-box/WD repeat-containing protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing |
| TREX1 protein network | https://string-db.org/network/9606.ENSP00000296443 | Three-prime repair exonuclease 1; Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intri [...] |
| SHISA5 protein network | https://string-db.org/network/9606.ENSP00000296444 | Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis; Shisa family members |
| BSN protein network | https://string-db.org/network/9606.ENSP00000296452 | Protein bassoon; Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to [...] |
| APEH protein network | https://string-db.org/network/9606.ENSP00000296456 | Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N- acetylated amino acid and a peptide with a free N [...] |
| HSPA4L protein network | https://string-db.org/network/9606.ENSP00000296464 | Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase; Belongs to the heat shock protein 70 family |
| MFSD8 protein network | https://string-db.org/network/9606.ENSP00000296468 | Major facilitator superfamily domain-containing protein 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients; Belongs to the major facilitator superfamily |
| MON1A protein network | https://string-db.org/network/9606.ENSP00000296473 | Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts i [...] |
| MST1R protein network | https://string-db.org/network/9606.ENSP00000296474 | Macrophage-stimulating protein receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological [...] |
| POC1A protein network | https://string-db.org/network/9606.ENSP00000296484 | POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps [...] |
| ETNPPL protein network | https://string-db.org/network/9606.ENSP00000296486 | Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde |
| WDR82 protein network | https://string-db.org/network/9606.ENSP00000296490 | WD repeat-containing protein 82; Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4 [...] |
| PRSS12 protein network | https://string-db.org/network/9606.ENSP00000296498 | Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations; Belongs to the peptidase S1 fa [...] |
| NDST3 protein network | https://string-db.org/network/9606.ENSP00000296499 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...] |
| HMGB2 protein network | https://string-db.org/network/9606.ENSP00000296503 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associa [...] |
| SAP30 protein network | https://string-db.org/network/9606.ENSP00000296504 | Histone deacetylase complex subunit SAP30; Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of t [...] |
| SCRG1 protein network | https://string-db.org/network/9606.ENSP00000296506 | Scrapie-responsive protein 1; Stimulator of chondrogenesis 1 |
| MAD2L1 protein network | https://string-db.org/network/9606.ENSP00000296509 | Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase pla [...] |
| ANXA5 protein network | https://string-db.org/network/9606.ENSP00000296511 | Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade; Annexins |
| ADAD1 protein network | https://string-db.org/network/9606.ENSP00000296513 | Adenosine deaminase domain-containing protein 1; Plays a role in spermatogenesis. Binds to RNA but not to DNA (By similarity); Adenosine deaminases acting on RNA |
| GUCY1A3 protein network | https://string-db.org/network/9606.ENSP00000296518 | Guanylate cyclase 1, soluble, alpha 3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family |
| HPGD protein network | https://string-db.org/network/9606.ENSP00000296522 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent [...] |
| ASB5 protein network | https://string-db.org/network/9606.ENSP00000296525 | Ankyrin repeat and SOCS box protein 5; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...] |
| GRIA2 protein network | https://string-db.org/network/9606.ENSP00000296526 | Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...] |
| TMEM144 protein network | https://string-db.org/network/9606.ENSP00000296529 | Transmembrane protein 144; Belongs to the TMEM144 family |
| NAA15 protein network | https://string-db.org/network/9606.ENSP00000296543 | N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT [...] |
| IL15 protein network | https://string-db.org/network/9606.ENSP00000296545 | Interleukin-15; Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R [...] |
| ICE1 protein network | https://string-db.org/network/9606.ENSP00000296564 | Little elongation complex subunit 1; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Sp [...] |
| HHIP protein network | https://string-db.org/network/9606.ENSP00000296575 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family |
| ABCE1 protein network | https://string-db.org/network/9606.ENSP00000296577 | ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhib [...] |
| TMEM184C protein network | https://string-db.org/network/9606.ENSP00000296582 | Transmembrane protein 184C; Possible tumor suppressor which may play a role in cell growth; Belongs to the TMEM184 family |
| ITGA2 protein network | https://string-db.org/network/9606.ENSP00000296585 | Integrin alpha-2; Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in c [...] |
| SLC45A2 protein network | https://string-db.org/network/9606.ENSP00000296589 | Membrane-associated transporter protein; Melanocyte differentiation antigen. May transport substances required for melanin biosynthesis (By similarity); Belongs to the glycoside-pentoside-hexuron [...] |
| EDIL3 protein network | https://string-db.org/network/9606.ENSP00000296591 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascu [...] |
| NDUFAF2 protein network | https://string-db.org/network/9606.ENSP00000296597 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NAD [...] |
| ZNF474 protein network | https://string-db.org/network/9606.ENSP00000296600 | Zinc finger protein 474; Zinc fingers C2H2-type |
| LMBRD2 protein network | https://string-db.org/network/9606.ENSP00000296603 | Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway . May also regulate other G-protein coupled receptors including t [...] |
| STARD4 protein network | https://string-db.org/network/9606.ENSP00000296632 | StAR-related lipid transfer protein 4; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfe [...] |
| F2RL2 protein network | https://string-db.org/network/9606.ENSP00000296641 | Proteinase-activated receptor 3; Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis; F2R receptors |
| ANKRD33B protein network | https://string-db.org/network/9606.ENSP00000296657 | Ankyrin repeat domain-containing protein 33B; Ankyrin repeat domain containing |
| CMBL protein network | https://string-db.org/network/9606.ENSP00000296658 | Carboxymethylenebutenolidase homolog; Cysteine hydrolase. Can convert the prodrug olmesartan medoxomil into its pharmacologically active metabolite olmerstatan, an angiotensin receptor blocker, i [...] |
| RPS23 protein network | https://string-db.org/network/9606.ENSP00000296674 | 40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RN [...] |
| F2RL1 protein network | https://string-db.org/network/9606.ENSP00000296677 | Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phosp [...] |
| WDR41 protein network | https://string-db.org/network/9606.ENSP00000296679 | WD repeat-containing protein 41; Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SM [...] |
| PRDM9 protein network | https://string-db.org/network/9606.ENSP00000296682 | Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. [...] |
| NDUFS4 protein network | https://string-db.org/network/9606.ENSP00000296684 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be [...] |
| SCGB3A2 protein network | https://string-db.org/network/9606.ENSP00000296694 | Secretoglobin family 3A member 2; Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram [...] |
| SPINK1 protein network | https://string-db.org/network/9606.ENSP00000296695 | Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By si [...] |
| TCERG1 protein network | https://string-db.org/network/9606.ENSP00000296702 | Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a T [...] |
| AFAP1L1 protein network | https://string-db.org/network/9606.ENSP00000296721 | Actin filament-associated protein 1-like 1; May be involved in podosome and invadosome formation; Pleckstrin homology domain containing |
| TIGD6 protein network | https://string-db.org/network/9606.ENSP00000296736 | Tigger transposable element-derived protein 6; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| ENPP6 protein network | https://string-db.org/network/9606.ENSP00000296741 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydro [...] |
| ERAP1 protein network | https://string-db.org/network/9606.ENSP00000296754 | Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is [...] |
| MAP1B protein network | https://string-db.org/network/9606.ENSP00000296755 | Microtubule-associated protein 1B; Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accomp [...] |
| TMEM174 protein network | https://string-db.org/network/9606.ENSP00000296776 | Transmembrane protein 174 |
| CARTPT protein network | https://string-db.org/network/9606.ENSP00000296777 | Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation- [...] |
| RICTOR protein network | https://string-db.org/network/9606.ENSP00000296782 | Rapamycin-insensitive companion of mTOR; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mT [...] |
| ANKRA2 protein network | https://string-db.org/network/9606.ENSP00000296785 | Ankyrin repeat family A protein 2; May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5. May also regulate LRP2/megalin (By similarity); Ankyrin repeat [...] |
| UBLCP1 protein network | https://string-db.org/network/9606.ENSP00000296786 | Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core [...] |
| UTP15 protein network | https://string-db.org/network/9606.ENSP00000296792 | U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription [...] |
| TLR3 protein network | https://string-db.org/network/9606.ENSP00000296795 | Toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific t [...] |
| GFM2 protein network | https://string-db.org/network/9606.ENSP00000296805 | Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in co [...] |
| CCDC127 protein network | https://string-db.org/network/9606.ENSP00000296824 | Coiled-coil domain containing 127 |
| FOXQ1 protein network | https://string-db.org/network/9606.ENSP00000296839 | Forkhead box protein Q1; Plays a role in hair follicle differentiation; Forkhead boxes |
| NKD2 protein network | https://string-db.org/network/9606.ENSP00000296849 | Protein naked cuticle homolog 2; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). [...] |
| RAPGEF6 protein network | https://string-db.org/network/9606.ENSP00000296859 | Rap guanine nucleotide exchange factor 6; Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP; PDZ domain containing |
| TNFRSF21 protein network | https://string-db.org/network/9606.ENSP00000296861 | Tumor necrosis factor receptor superfamily member 21; Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the [...] |
| GPR111 protein network | https://string-db.org/network/9606.ENSP00000296862 | Adhesion G-protein coupled receptor F2; Orphan receptor |
| IL3 protein network | https://string-db.org/network/9606.ENSP00000296870 | Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell popul [...] |
| CSF2 protein network | https://string-db.org/network/9606.ENSP00000296871 | Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophag [...] |
| LEAP2 protein network | https://string-db.org/network/9606.ENSP00000296877 | Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity |
| TLX3 protein network | https://string-db.org/network/9606.ENSP00000296921 | T-cell leukemia homeobox protein 3; NKL subclass homeoboxes and pseudogenes |
| NPM1 protein network | https://string-db.org/network/9606.ENSP00000296930 | Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppr [...] |
| T protein network | https://string-db.org/network/9606.ENSP00000296946 | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcri [...] |
| CREBRF protein network | https://string-db.org/network/9606.ENSP00000296953 | CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the U [...] |
| DCBLD1 protein network | https://string-db.org/network/9606.ENSP00000296955 | Discoidin, CUB and LCCL domain containing 1 |
| IL22RA2 protein network | https://string-db.org/network/9606.ENSP00000296980 | Interleukin-22 receptor subunit alpha-2; Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May p [...] |
| C7orf72 protein network | https://string-db.org/network/9606.ENSP00000297001 | Spermatogenesis-associated protein 48; Chromosome 7 open reading frame 72 |
| HIST1H2AA protein network | https://string-db.org/network/9606.ENSP00000297012 | Histone H2A type 1-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| SCIN protein network | https://string-db.org/network/9606.ENSP00000297029 | Adseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. [...] |
| CYTH3 protein network | https://string-db.org/network/9606.ENSP00000297044 | Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By simi [...] |
| DAGLB protein network | https://string-db.org/network/9606.ENSP00000297056 | Sn1-specific diacylglycerol lipase beta; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal gro [...] |
| KIAA0895 protein network | https://string-db.org/network/9606.ENSP00000297063 | Uncharacterized protein KIAA0895; KIAA0895 |
| TRA2A protein network | https://string-db.org/network/9606.ENSP00000297071 | Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing |
| GALNT10 protein network | https://string-db.org/network/9606.ENSP00000297107 | Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| SAP30L protein network | https://string-db.org/network/9606.ENSP00000297109 | Histone deacetylase complex subunit SAP30L; Isoform 1: Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitmen [...] |
| MYOZ3 protein network | https://string-db.org/network/9606.ENSP00000297130 | Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...] |
| COG5 protein network | https://string-db.org/network/9606.ENSP00000297135 | Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function; Belongs to the COG5 family |
| NEUROD6 protein network | https://string-db.org/network/9606.ENSP00000297142 | Neurogenic differentiation factor 6; Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammal [...] |
| C7orf60 protein network | https://string-db.org/network/9606.ENSP00000297145 | Probable methyltransferase BMT2 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase |
| GPR85 protein network | https://string-db.org/network/9606.ENSP00000297146 | Probable G-protein coupled receptor 85; Orphan receptor; Belongs to the G-protein coupled receptor 1 family |
| SLU7 protein network | https://string-db.org/network/9606.ENSP00000297151 | Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'- splice site to generate spliced mRNA and the [...] |
| CAMLG protein network | https://string-db.org/network/9606.ENSP00000297156 | Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B |
| RP9 protein network | https://string-db.org/network/9606.ENSP00000297157 | Retinitis pigmentosa 9 protein; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) |
| BMPER protein network | https://string-db.org/network/9606.ENSP00000297161 | BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes |
| RELL2 protein network | https://string-db.org/network/9606.ENSP00000297164 | Induces activation of MAPK14/p38 cascade, when overexpressed . Induces apoptosis, when overexpressed |
| HSPA9 protein network | https://string-db.org/network/9606.ENSP00000297185 | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly protein [...] |
| C7orf62 protein network | https://string-db.org/network/9606.ENSP00000297203 | Testis-expressed protein 47; Chromosome 7 open reading frame 62 |
| STEAP1 protein network | https://string-db.org/network/9606.ENSP00000297205 | Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity); Belongs to the STEAP family |
| FABP5 protein network | https://string-db.org/network/9606.ENSP00000297258 | Fatty acid-binding protein, epidermal; High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May b [...] |
| SHH protein network | https://string-db.org/network/9606.ENSP00000297261 | Sonic hedgehog protein; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Bot [...] |
| CHMP4C protein network | https://string-db.org/network/9606.ENSP00000297265 | Charged multivesicular body protein 4c; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| FNDC1 protein network | https://string-db.org/network/9606.ENSP00000297267 | Fibronectin type III domain-containing protein 1; May be an activator of G protein signaling; Fibronectin type III domain containing |
| COL1A2 protein network | https://string-db.org/network/9606.ENSP00000297268 | Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family |
| CASD1 protein network | https://string-db.org/network/9606.ENSP00000297273 | N-acetylneuraminate 9-O-acetyltransferase; O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and ar [...] |
| SLC13A4 protein network | https://string-db.org/network/9606.ENSP00000297282 | Solute carrier family 13 member 4; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the high endothelial venules (HEV); Solute carriers |
| PGAM2 protein network | https://string-db.org/network/9606.ENSP00000297283 | Phosphoglycerate mutase 2; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but w [...] |
| BRI3 protein network | https://string-db.org/network/9606.ENSP00000297290 | Brain protein I3; Participates in tumor necrosis factor-alpha (TNF)- induced cell death. May be a target of Wnt/beta- catenin signaling in the liver; Belongs to the BRI3 family |
| LMTK2 protein network | https://string-db.org/network/9606.ENSP00000297293 | Serine/threonine-protein kinase LMTK2; Phosphorylates PPP1C, phosphorylase b and CFTR; Protein phosphatase 1 regulatory subunits |
| SLC35G3 protein network | https://string-db.org/network/9606.ENSP00000297307 | Solute carrier family 35 member G3 |
| RGS20 protein network | https://string-db.org/network/9606.ENSP00000297313 | Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds sele [...] |
| SOX17 protein network | https://string-db.org/network/9606.ENSP00000297316 | Transcription factor SOX-17; Acts as transcription regulator that binds target promoter DNA and bends the DNA. Binds to the sequences 5'- AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional reg [...] |
| ADCY1 protein network | https://string-db.org/network/9606.ENSP00000297323 | Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similari [...] |
| C8orf48 protein network | https://string-db.org/network/9606.ENSP00000297324 | Uncharacterized protein C8orf48; Chromosome 8 open reading frame 48 |
| SUN3 protein network | https://string-db.org/network/9606.ENSP00000297325 | SUN domain-containing protein 3; As a probable component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleto [...] |
| RAD21 protein network | https://string-db.org/network/9606.ENSP00000297338 | Double-strand-break repair protein rad21 homolog; Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin compl [...] |
| MED30 protein network | https://string-db.org/network/9606.ENSP00000297347 | Mediator of RNA polymerase II transcription subunit 30; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| TNFRSF11B protein network | https://string-db.org/network/9606.ENSP00000297350 | Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts [...] |
| SBSPON protein network | https://string-db.org/network/9606.ENSP00000297354 | Somatomedin-B and thrombospondin type-1 domain-containing protein; Somatomedin B and thrombospondin type 1 domain containing; Belongs to the thrombospondin family |
| EN2 protein network | https://string-db.org/network/9606.ENSP00000297375 | Homeobox protein engrailed-2; NKL subclass homeoboxes and pseudogenes; Belongs to the engrailed homeobox family |
| CSMD3 protein network | https://string-db.org/network/9606.ENSP00000297405 | CUB and sushi domain-containing protein 3; Involved in dendrite development; Sushi domain containing |
| SPIDR protein network | https://string-db.org/network/9606.ENSP00000297423 | DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DN [...] |
| ORC5 protein network | https://string-db.org/network/9606.ENSP00000297431 | Origin recognition complex subunit 5; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...] |
| DEFA4 protein network | https://string-db.org/network/9606.ENSP00000297435 | Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Protects blood cells against infection with [...] |
| DEFA6 protein network | https://string-db.org/network/9606.ENSP00000297436 | Defensin-6; Has very low antimicrobial activity against Gram- negative and Gram-positive bacteria. May protect cells against infection with HIV-1; Defensins, alpha |
| DEFB1 protein network | https://string-db.org/network/9606.ENSP00000297439 | Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Bind [...] |
| HEATR2 protein network | https://string-db.org/network/9606.ENSP00000297440 | Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and out [...] |
| TMEM74 protein network | https://string-db.org/network/9606.ENSP00000297459 | Transmembrane protein 74; Plays an essential role in autophagy. TMEM74-induced autophagy may involve PI3K signal transduction; Belongs to the TMEM74 family |
| TMEM184A protein network | https://string-db.org/network/9606.ENSP00000297477 | Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity) |
| NOS3 protein network | https://string-db.org/network/9606.ENSP00000297494 | Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular e [...] |
| ABCB8 protein network | https://string-db.org/network/9606.ENSP00000297504 | ATP-binding cassette sub-family B member 8, mitochondrial; ATP binding cassette subfamily B member 8; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3. [...] |
| MICALL2 protein network | https://string-db.org/network/9606.ENSP00000297508 | MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin [...] |
| ASIC3 protein network | https://string-db.org/network/9606.ENSP00000297512 | Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast [...] |
| SLC7A13 protein network | https://string-db.org/network/9606.ENSP00000297524 | Solute carrier family 7 member 13; Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner; Belongs to the amino acid-polyamine-organocation (APC) superfamily |
| FASTK protein network | https://string-db.org/network/9606.ENSP00000297532 | Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the recep [...] |
| C7orf55 protein network | https://string-db.org/network/9606.ENSP00000297534 | Protein FMC1 homolog; Chromosome 7 open reading frame 55 |
| GBX1 protein network | https://string-db.org/network/9606.ENSP00000297537 | Homeobox protein GBX-1; Gastrulation brain homeobox 1; HOXL subclass homeoboxes |
| PHAX protein network | https://string-db.org/network/9606.ENSP00000297540 | Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding c [...] |
| AP5Z1 protein network | https://string-db.org/network/9606.ENSP00000297562 | AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required f [...] |
| SLC25A32 protein network | https://string-db.org/network/9606.ENSP00000297578 | Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| DCAF13 protein network | https://string-db.org/network/9606.ENSP00000297579 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CU [...] |
| DCSTAMP protein network | https://string-db.org/network/9606.ENSP00000297581 | Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF [...] |
| KIAA1429 protein network | https://string-db.org/network/9606.ENSP00000297591 | Protein virilizer homolog; Required for N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and processing. Involved in mRNA splicin [...] |
| GEM protein network | https://string-db.org/network/9606.ENSP00000297596 | GTP-binding protein GEM; Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetec [...] |
| RPP25L protein network | https://string-db.org/network/9606.ENSP00000297613 | Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP |
| C9orf24 protein network | https://string-db.org/network/9606.ENSP00000297623 | Spermatid-specific manchette-related protein 1; May play a role in spermatogenesis (By similarity). May be involved in differentiation or function of ciliated cells; Belongs to the SMRP1 family |
| KIAA1161 protein network | https://string-db.org/network/9606.ENSP00000297625 | Myogenesis-regulating glycosidase; Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2; Belongs to the glycosyl hydrolase 31 family |
| TMEM65 protein network | https://string-db.org/network/9606.ENSP00000297632 | Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contributes to the [...] |
| UBAP1 protein network | https://string-db.org/network/9606.ENSP00000297661 | Ubiquitin-associated protein 1; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic [...] |
| CNTNAP3 protein network | https://string-db.org/network/9606.ENSP00000297668 | Contactin-associated protein-like 3; Contactin associated protein like 3 |
| HSD3B7 protein network | https://string-db.org/network/9606.ENSP00000297679 | 3 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hy [...] |
| NFIL3 protein network | https://string-db.org/network/9606.ENSP00000297689 | Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and vi [...] |
| ZMAT4 protein network | https://string-db.org/network/9606.ENSP00000297737 | Zinc finger matrin-type 4 |
| PRSS37 protein network | https://string-db.org/network/9606.ENSP00000297767 | Probable inactive serine protease 37; Plays a role in male fertility (By similarity). May have a role in sperm migration or binding to zona-intact eggs (By similarity). Involved in the activation [...] |
| CPA6 protein network | https://string-db.org/network/9606.ENSP00000297770 | Carboxypeptidase A6; May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensi [...] |
| TMC1 protein network | https://string-db.org/network/9606.ENSP00000297784 | Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family |
| ALDH1A1 protein network | https://string-db.org/network/9606.ENSP00000297785 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity [...] |
| CCDC136 protein network | https://string-db.org/network/9606.ENSP00000297788 | Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization |
| KDM1B protein network | https://string-db.org/network/9606.ENSP00000297792 | Lysine-specific histone demethylase 1B; Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Req [...] |
| KIF27 protein network | https://string-db.org/network/9606.ENSP00000297814 | Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis; Kinesins |
| SSMEM1 protein network | https://string-db.org/network/9606.ENSP00000297819 | Serine rich single-pass membrane protein 1 |
| ANKS6 protein network | https://string-db.org/network/9606.ENSP00000297837 | Ankyrin repeat and SAM domain-containing protein 6; Required for renal function; Ankyrin repeat domain containing |
| COL14A1 protein network | https://string-db.org/network/9606.ENSP00000297848 | Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then [...] |
| ZHX1 protein network | https://string-db.org/network/9606.ENSP00000297857 | Zinc fingers and homeoboxes protein 1; Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule betwee [...] |
| CXorf22 protein network | https://string-db.org/network/9606.ENSP00000297866 | Cilia- and flagella-associated protein 47; Chromosome X open reading frame 22 |
| WBSCR27 protein network | https://string-db.org/network/9606.ENSP00000297873 | Methyltransferase-like protein 27; Williams Beuren syndrome chromosome region 27 |
| FIGF protein network | https://string-db.org/network/9606.ENSP00000297904 | Vascular endothelial growth factor D; Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on th [...] |
| OR1Q1 protein network | https://string-db.org/network/9606.ENSP00000297913 | Olfactory receptor 1Q1; Odorant receptor; Olfactory receptors, family 1 |
| WNK2 protein network | https://string-db.org/network/9606.ENSP00000297954 | Serine/threonine-protein kinase WNK2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an a [...] |
| HDX protein network | https://string-db.org/network/9606.ENSP00000297977 | Highly divergent homeobox; POU class homeoboxes and pseudogenes |
| AQP7 protein network | https://string-db.org/network/9606.ENSP00000297988 | Aquaporin-7; Forms a channel for water and glycerol; Aquaporins |
| NOL6 protein network | https://string-db.org/network/9606.ENSP00000297990 | Nucleolar protein 6; Belongs to the NRAP family |
| AQP3 protein network | https://string-db.org/network/9606.ENSP00000297991 | Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC [...] |
| TRMT10B protein network | https://string-db.org/network/9606.ENSP00000297994 | tRNA methyltransferase 10 homolog B; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)- methylguanine at position 9 (m1G9) in tRNAs. Probably [...] |
| ARMC3 protein network | https://string-db.org/network/9606.ENSP00000298032 | Armadillo repeat containing 3 |
| MELK protein network | https://string-db.org/network/9606.ENSP00000298048 | Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulatio [...] |
| CCDC67 protein network | https://string-db.org/network/9606.ENSP00000298050 | Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole ampli [...] |
| FBXO33 protein network | https://string-db.org/network/9606.ENSP00000298097 | F-box only protein 33; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degrada [...] |
| GPR101 protein network | https://string-db.org/network/9606.ENSP00000298110 | Probable G-protein coupled receptor 101; Orphan receptor; G protein-coupled receptors, Class A orphans |
| LRFN5 protein network | https://string-db.org/network/9606.ENSP00000298119 | Leucine-rich repeat and fibronectin type-III domain-containing protein 5; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outg [...] |
| LRRC18 protein network | https://string-db.org/network/9606.ENSP00000298124 | Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation |
| WDFY2 protein network | https://string-db.org/network/9606.ENSP00000298125 | WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-depende [...] |
| SPTSSA protein network | https://string-db.org/network/9606.ENSP00000298130 | Serine palmitoyltransferase small subunit A; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrat [...] |
| WRN protein network | https://string-db.org/network/9606.ENSP00000298139 | Werner syndrome ATP-dependent helicase; Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a [...] |
| CFL2 protein network | https://string-db.org/network/9606.ENSP00000298159 | Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability [...] |
| SSX7 protein network | https://string-db.org/network/9606.ENSP00000298181 | Protein SSX7; Could act as a modulator of transcription |
| PGM2L1 protein network | https://string-db.org/network/9606.ENSP00000298198 | Glucose 1,6-bisphosphate synthase; Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors, including glucose 1-phos [...] |
| FOLR2 protein network | https://string-db.org/network/9606.ENSP00000298223 | Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for fol [...] |
| INPPL1 protein network | https://string-db.org/network/9606.ENSP00000298229 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdI [...] |
| PHOX2A protein network | https://string-db.org/network/9606.ENSP00000298231 | Paired mesoderm homeobox protein 2A; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain [...] |
| CRYL1 protein network | https://string-db.org/network/9606.ENSP00000298248 | Lambda-crystallin homolog; Crystallin lambda 1 |
| HEPACAM protein network | https://string-db.org/network/9606.ENSP00000298251 | Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation; Ig-like cell adhesion mole [...] |
| PCF11 protein network | https://string-db.org/network/9606.ENSP00000298281 | Pre-mRNA cleavage complex 2 protein Pcf11; Component of pre-mRNA cleavage complex II |
| PKNOX2 protein network | https://string-db.org/network/9606.ENSP00000298282 | Homeobox protein PKNOX2; TALE class homeoboxes and pseudogenes; Belongs to the TALE/MEIS homeobox family |
| RPL10L protein network | https://string-db.org/network/9606.ENSP00000298283 | 60S ribosomal protein L10-like; May play a role in compensating for the inactivated X- linked gene during spermatogenesis; L ribosomal proteins |
| LRR1 protein network | https://string-db.org/network/9606.ENSP00000298288 | Leucine-rich repeat protein 1; May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. Probable substrate recognition subunit of an ECS [...] |
| DNAAF2 protein network | https://string-db.org/network/9606.ENSP00000298292 | Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in t [...] |
| C10orf10 protein network | https://string-db.org/network/9606.ENSP00000298295 | Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS |
| MAGEC3 protein network | https://string-db.org/network/9606.ENSP00000298296 | Melanoma-associated antigen C3; MAGE family member C3 |
| C10orf25 protein network | https://string-db.org/network/9606.ENSP00000298298 | Uncharacterized protein C10orf25; Chromosome 10 open reading frame 25 |
| ZNF22 protein network | https://string-db.org/network/9606.ENSP00000298299 | Zinc finger protein 22; Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation (By similarity); Zinc fingers C2 [...] |
| KLHDC2 protein network | https://string-db.org/network/9606.ENSP00000298307 | Kelch domain-containing protein 2; Represses CREB3-mediated transcription by interfering with CREB3-DNA binding |
| NEMF protein network | https://string-db.org/network/9606.ENSP00000298310 | Nuclear export mediator factor NEMF; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized [...] |
| ARF6 protein network | https://string-db.org/network/9606.ENSP00000298316 | ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesi [...] |
| RPUSD4 protein network | https://string-db.org/network/9606.ENSP00000298317 | Mitochondrial RNA pseudouridine synthase RPUSD4; Converts specific uridines to pseudouridine (PSI) in different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal [...] |
| TMEM63C protein network | https://string-db.org/network/9606.ENSP00000298351 | Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel |
| NGB protein network | https://string-db.org/network/9606.ENSP00000298352 | Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell [...] |
| TRIM9 protein network | https://string-db.org/network/9606.ENSP00000298355 | E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation [...] |
| AKR1E2 protein network | https://string-db.org/network/9606.ENSP00000298375 | 1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol (By similarity). Has low NADPH-dependent reductase activity tow [...] |
| RXFP2 protein network | https://string-db.org/network/9606.ENSP00000298386 | Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for L [...] |
| SSX3 protein network | https://string-db.org/network/9606.ENSP00000298396 | Protein SSX3; Could act as a modulator of transcription; Belongs to the SSX family |
| SEC61A2 protein network | https://string-db.org/network/9606.ENSP00000298428 | Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membran [...] |
| OXGR1 protein network | https://string-db.org/network/9606.ENSP00000298440 | 2-oxoglutarate receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) |
| SLC18A2 protein network | https://string-db.org/network/9606.ENSP00000298472 | Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, seroton [...] |
| FAM175B protein network | https://string-db.org/network/9606.ENSP00000298492 | BRISC complex subunit Abraxas 2; Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its s [...] |
| PRDX3 protein network | https://string-db.org/network/9606.ENSP00000298510 | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively [...] |
| CLEC1B protein network | https://string-db.org/network/9606.ENSP00000298527 | C-type lectin domain family 1 member B; C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequenti [...] |
| SNAPC4 protein network | https://string-db.org/network/9606.ENSP00000298532 | snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...] |
| FRMD7 protein network | https://string-db.org/network/9606.ENSP00000298542 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability; FERM domai [...] |
| AK8 protein network | https://string-db.org/network/9606.ENSP00000298545 | Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest a [...] |
| C9orf9 protein network | https://string-db.org/network/9606.ENSP00000298546 | Sperm acrosome-associated protein 9; Chromosome 9 open reading frame 9 |
| TSC1 protein network | https://string-db.org/network/9606.ENSP00000298552 | Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required [...] |
| HPRT1 protein network | https://string-db.org/network/9606.ENSP00000298556 | Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosyl [...] |
| KIAA1191 protein network | https://string-db.org/network/9606.ENSP00000298569 | Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth; Belongs to the P33MONOX fa [...] |
| DUSP16 protein network | https://string-db.org/network/9606.ENSP00000298573 | Dual specificity protein phosphatase 16; Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2; Belongs to the protein-tyrosine [...] |
| ZMYND19 protein network | https://string-db.org/network/9606.ENSP00000298585 | Zinc finger MYND domain-containing protein 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling; Zinc fingers MYND-type |
| STOX1 protein network | https://string-db.org/network/9606.ENSP00000298596 | Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of [...] |
| JAKMIP3 protein network | https://string-db.org/network/9606.ENSP00000298622 | Janus kinase and microtubule interacting protein 3 |
| STK32C protein network | https://string-db.org/network/9606.ENSP00000298630 | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| OR4K2 protein network | https://string-db.org/network/9606.ENSP00000298642 | Olfactory receptor 4K2; Odorant receptor; Olfactory receptors, family 4 |
| SLC39A2 protein network | https://string-db.org/network/9606.ENSP00000298681 | Zinc transporter ZIP2; Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cat [...] |
| RNASE7 protein network | https://string-db.org/network/9606.ENSP00000298690 | Ribonuclease 7; Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) agai [...] |
| ARHGEF40 protein network | https://string-db.org/network/9606.ENSP00000298694 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) |
| C12orf50 protein network | https://string-db.org/network/9606.ENSP00000298699 | Uncharacterized protein C12orf50; Chromosome 12 open reading frame 50 |
| PPP1R36 protein network | https://string-db.org/network/9606.ENSP00000298705 | Protein phosphatase 1 regulatory subunit 36; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes |
| METTL3 protein network | https://string-db.org/network/9606.ENSP00000298717 | N6-adenosine-methyltransferase catalytic subunit; The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and reg [...] |
| ERICH6B protein network | https://string-db.org/network/9606.ENSP00000298738 | Glutamate-rich protein 6B; Glutamate rich 6B |
| GAS1 protein network | https://string-db.org/network/9606.ENSP00000298743 | Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells |
| TRUB1 protein network | https://string-db.org/network/9606.ENSP00000298746 | Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs |
| WAPAL protein network | https://string-db.org/network/9606.ENSP00000298767 | Wings apart-like protein homolog; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion durin [...] |
| FAM35A protein network | https://string-db.org/network/9606.ENSP00000298784 | Protein FAM35A; Family with sequence similarity 35 member A |
| ARHGAP42 protein network | https://string-db.org/network/9606.ENSP00000298815 | Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle |
| TTLL5 protein network | https://string-db.org/network/9606.ENSP00000298832 | Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elonga [...] |
| RAPSN protein network | https://string-db.org/network/9606.ENSP00000298854 | 43 kDa receptor-associated protein of the synapse; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the recept [...] |
| CPSF2 protein network | https://string-db.org/network/9606.ENSP00000298875 | Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recog [...] |
| CAPRIN2 protein network | https://string-db.org/network/9606.ENSP00000298892 | Caprin-2; Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY dur [...] |
| LRRK2 protein network | https://string-db.org/network/9606.ENSP00000298910 | Leucine-rich repeat serine/threonine-protein kinase 2; Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation [...] |
| CLMN protein network | https://string-db.org/network/9606.ENSP00000298912 | Calmin |
| NELL1 protein network | https://string-db.org/network/9606.ENSP00000298925 | Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization |
| C1QL3 protein network | https://string-db.org/network/9606.ENSP00000298943 | Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose [...] |
| SMCO4 protein network | https://string-db.org/network/9606.ENSP00000298966 | Single-pass membrane protein with coiled-coil domains 4; Belongs to the SMCO4 family |
| PIWIL4 protein network | https://string-db.org/network/9606.ENSP00000299001 | Piwi-like protein 4; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarit [...] |
| LIPC protein network | https://string-db.org/network/9606.ENSP00000299022 | Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL m [...] |
| TCP11L2 protein network | https://string-db.org/network/9606.ENSP00000299045 | T-complex protein 11-like protein 2; T-complex 11 like 2 |
| SPRED1 protein network | https://string-db.org/network/9606.ENSP00000299084 | Sprouty-related, EVH1 domain-containing protein 1; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow (By [...] |
| C14orf93 protein network | https://string-db.org/network/9606.ENSP00000299088 | Uncharacterized protein C14orf93; Chromosome 14 open reading frame 93 |
| JAM3 protein network | https://string-db.org/network/9606.ENSP00000299106 | Junctional adhesion molecule C; Participates in cell-cell adhesion. It is a counter- receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithe [...] |
| VPS35 protein network | https://string-db.org/network/9606.ENSP00000299138 | Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...] |
| SPATA19 protein network | https://string-db.org/network/9606.ENSP00000299140 | Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis |
| AMN protein network | https://string-db.org/network/9606.ENSP00000299155 | Protein amnionless; Necessary for efficient absorption of vitamin B12. Required for normal CUBN- mediated protein transport in the kidney. May direct the production of trunk mesoderm during devel [...] |
| IKBIP protein network | https://string-db.org/network/9606.ENSP00000299157 | IKBKB interacting protein |
| FOXN4 protein network | https://string-db.org/network/9606.ENSP00000299162 | Forkhead box protein N4; Transcription factor essential for neural and some non- neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing [...] |
| HIF1AN protein network | https://string-db.org/network/9606.ENSP00000299163 | Hypoxia-inducible factor 1-alpha inhibitor; Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the [...] |
| ADAMTS15 protein network | https://string-db.org/network/9606.ENSP00000299164 | ADAM metallopeptidase with thrombospondin type 1 motif 15 |
| NDUFB8 protein network | https://string-db.org/network/9606.ENSP00000299166 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...] |
| AVPR1A protein network | https://string-db.org/network/9606.ENSP00000299178 | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Has b [...] |
| C16orf78 protein network | https://string-db.org/network/9606.ENSP00000299191 | Uncharacterized protein C16orf78; Chromosome 16 open reading frame 78 |
| HEATR3 protein network | https://string-db.org/network/9606.ENSP00000299192 | HEAT repeat-containing protein 3; Armadillo-like helical domain containing |
| CKB protein network | https://string-db.org/network/9606.ENSP00000299198 | Creatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy tran [...] |
| LARP6 protein network | https://string-db.org/network/9606.ENSP00000299213 | La-related protein 6; Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure [...] |
| ZNF319 protein network | https://string-db.org/network/9606.ENSP00000299237 | Zinc finger protein 319; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HPS6 protein network | https://string-db.org/network/9606.ENSP00000299238 | Hermansky-Pudlak syndrome 6 protein; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as cargo adap [...] |
| COPS2 protein network | https://string-db.org/network/9606.ENSP00000299259 | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential [...] |
| TBATA protein network | https://string-db.org/network/9606.ENSP00000299290 | Protein TBATA; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function |
| CHODL protein network | https://string-db.org/network/9606.ENSP00000299295 | Chondrolectin; May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance; C-type lectin domain contai [...] |
| PCBD1 protein network | https://string-db.org/network/9606.ENSP00000299299 | Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator [...] |
| CCT2 protein network | https://string-db.org/network/9606.ENSP00000299300 | T-complex protein 1 subunit beta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex inv [...] |
| TMEM132B protein network | https://string-db.org/network/9606.ENSP00000299308 | Transmembrane protein 132B; Belongs to the TMEM132 family |
| GNPTAB protein network | https://string-db.org/network/9606.ENSP00000299314 | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residu [...] |
| C16orf71 protein network | https://string-db.org/network/9606.ENSP00000299320 | Uncharacterized protein C16orf71; Chromosome 16 open reading frame 71 |
| COX11 protein network | https://string-db.org/network/9606.ENSP00000299335 | Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B [...] |
| FAM227B protein network | https://string-db.org/network/9606.ENSP00000299338 | Protein FAM227B; Family with sequence similarity 227 member B |
| CLDN10 protein network | https://string-db.org/network/9606.ENSP00000299339 | Claudin-10; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. May form permselective paracellular pores; [...] |
| CYYR1 protein network | https://string-db.org/network/9606.ENSP00000299340 | Cysteine and tyrosine rich 1 |
| C2 protein network | https://string-db.org/network/9606.ENSP00000299367 | Complement C2; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combine [...] |
| TRIM44 protein network | https://string-db.org/network/9606.ENSP00000299413 | Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17. Is a negative regu [...] |
| CCDC182 protein network | https://string-db.org/network/9606.ENSP00000299415 | Coiled-coil domain containing 182 |
| TAF10 protein network | https://string-db.org/network/9606.ENSP00000299424 | Transcription initiation factor TFIID subunit 10; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a [...] |
| TPP1 protein network | https://string-db.org/network/9606.ENSP00000299427 | Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products pro [...] |
| MSS51 protein network | https://string-db.org/network/9606.ENSP00000299432 | Putative protein MSS51 homolog, mitochondrial; MSS51 mitochondrial translational activator; Zinc fingers MYND-type |
| RAG1 protein network | https://string-db.org/network/9606.ENSP00000299440 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assem [...] |
| DCHS1 protein network | https://string-db.org/network/9606.ENSP00000299441 | Protocadherin-16; Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis [...] |
| POTED protein network | https://string-db.org/network/9606.ENSP00000299443 | POTE ankyrin domain family member D; Belongs to the POTE family |
| OR10A5 protein network | https://string-db.org/network/9606.ENSP00000299454 | Olfactory receptor 10A5; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 10 |
| OR2D2 protein network | https://string-db.org/network/9606.ENSP00000299459 | Olfactory receptor 2D2; Odorant receptor; Olfactory receptors, family 2 |
| NLRP14 protein network | https://string-db.org/network/9606.ENSP00000299481 | NACHT, LRR and PYD domains-containing protein 14; May be involved in inflammation and spermatogenesis; NLR family |
| PPFIBP2 protein network | https://string-db.org/network/9606.ENSP00000299492 | Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing |
| KIAA0355 protein network | https://string-db.org/network/9606.ENSP00000299505 | Uncharacterized protein KIAA0355; KIAA0355 |
| IDH3A protein network | https://string-db.org/network/9606.ENSP00000299518 | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer comp [...] |
| CRABP1 protein network | https://string-db.org/network/9606.ENSP00000299529 | Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors; Belongs to the calycin superfamily. Fatty-acid binding [...] |
| RNF169 protein network | https://string-db.org/network/9606.ENSP00000299563 | E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair site [...] |
| CHRNA5 protein network | https://string-db.org/network/9606.ENSP00000299565 | Neuronal acetylcholine receptor subunit alpha-5; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| ATMIN protein network | https://string-db.org/network/9606.ENSP00000299575 | ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absen [...] |
| C16orf46 protein network | https://string-db.org/network/9606.ENSP00000299578 | Uncharacterized protein C16orf46; Chromosome 16 open reading frame 46 |
| LEO1 protein network | https://string-db.org/network/9606.ENSP00000299601 | RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development [...] |
| TMX3 protein network | https://string-db.org/network/9606.ENSP00000299608 | Protein disulfide-isomerase TMX3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase |
| ALG8 protein network | https://string-db.org/network/9606.ENSP00000299626 | Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers [...] |
| HDGFRP3 protein network | https://string-db.org/network/9606.ENSP00000299633 | Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation |
| POLR2M protein network | https://string-db.org/network/9606.ENSP00000299638 | DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many [...] |
| CLEC3A protein network | https://string-db.org/network/9606.ENSP00000299642 | C-type lectin domain family 3 member A; Promotes cell adhesion to laminin-332 and fibronectin; C-type lectin domain containing |
| CLEC4E protein network | https://string-db.org/network/9606.ENSP00000299663 | C-type lectin domain family 4 member E; C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the reco [...] |
| CLEC4D protein network | https://string-db.org/network/9606.ENSP00000299665 | C-type lectin domain family 4 member D; Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and [...] |
| ZNF407 protein network | https://string-db.org/network/9606.ENSP00000299687 | Zinc finger protein 407; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TK2 protein network | https://string-db.org/network/9606.ENSP00000299697 | Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulate [...] |
| A2ML1 protein network | https://string-db.org/network/9606.ENSP00000299698 | Alpha-2-macroglobulin-like protein 1; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which conta [...] |
| TMED3 protein network | https://string-db.org/network/9606.ENSP00000299705 | Transmembrane emp24 domain-containing protein 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED1 [...] |
| SLC38A8 protein network | https://string-db.org/network/9606.ENSP00000299709 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter; Belongs to the amino acid/polyamine transporter 2 family |
| CPLX4 protein network | https://string-db.org/network/9606.ENSP00000299721 | Complexin-4; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family |
| GALR1 protein network | https://string-db.org/network/9606.ENSP00000299727 | Galanin receptor type 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled recept [...] |
| IQCD protein network | https://string-db.org/network/9606.ENSP00000299732 | IQ domain-containing protein D; Cilia and flagella associated |
| CENPV protein network | https://string-db.org/network/9606.ENSP00000299736 | Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis |
| CDH16 protein network | https://string-db.org/network/9606.ENSP00000299752 | Cadherin-16; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| RRAD protein network | https://string-db.org/network/9606.ENSP00000299759 | GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channe [...] |
| MC4R protein network | https://string-db.org/network/9606.ENSP00000299766 | Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic [...] |
| HSP90B1 protein network | https://string-db.org/network/9606.ENSP00000299767 | Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity [...] |
| SLC9A5 protein network | https://string-db.org/network/9606.ENSP00000299798 | Sodium/hydrogen exchanger 5; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| NCAPH2 protein network | https://string-db.org/network/9606.ENSP00000299821 | Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishin [...] |
| PPP1R16B protein network | https://string-db.org/network/9606.ENSP00000299824 | Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in [...] |
| CHRFAM7A protein network | https://string-db.org/network/9606.ENSP00000299847 | CHRNA7-FAM7A fusion protein; CHRNA7 fusion; Belongs to the ligand-gated ion channel (TC 1.A.9) family |
| POLR3E protein network | https://string-db.org/network/9606.ENSP00000299853 | DNA-directed RNA polymerase III subunit RPC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| MMP3 protein network | https://string-db.org/network/9606.ENSP00000299855 | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase [...] |
| TVP23A protein network | https://string-db.org/network/9606.ENSP00000299866 | Trans-golgi network vesicle protein 23 homolog A; Belongs to the TVP23 family |
| ZNF211 protein network | https://string-db.org/network/9606.ENSP00000299871 | Zinc finger protein 211; Zinc fingers C2H2-type |
| TMPRSS5 protein network | https://string-db.org/network/9606.ENSP00000299882 | Transmembrane protease serine 5; May play a role in hearing; Belongs to the peptidase S1 family |
| COG1 protein network | https://string-db.org/network/9606.ENSP00000299886 | Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function; Components of oligomeric golgi complex |
| MARVELD3 protein network | https://string-db.org/network/9606.ENSP00000299952 | MARVEL domain containing 3 |
| CASC4 protein network | https://string-db.org/network/9606.ENSP00000299957 | Protein CASC4; Cancer susceptibility 4; Belongs to the GOLM1/CASC4 family |
| SLFN5 protein network | https://string-db.org/network/9606.ENSP00000299977 | Schlafen family member 5; May have a role in hematopoietic cell differentiation; Schlafen family |
| C16orf45 protein network | https://string-db.org/network/9606.ENSP00000300006 | Uncharacterized protein C16orf45; Chromosome 16 open reading frame 45 |
| PPIB protein network | https://string-db.org/network/9606.ENSP00000300026 | Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylp [...] |
| FAM96A protein network | https://string-db.org/network/9606.ENSP00000300030 | MIP18 family protein FAM96A; May play a role in chromosome segregation through establishment of sister chromatid cohesion; Belongs to the MIP18 family |
| KIAA0101 protein network | https://string-db.org/network/9606.ENSP00000300035 | PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interact [...] |
| LDHD protein network | https://string-db.org/network/9606.ENSP00000300051 | Probable D-lactate dehydrogenase, mitochondrial; Lactate dehydrogenase D; Belongs to the FAD-binding oxidoreductase/transferase type 4 family |
| PLIN1 protein network | https://string-db.org/network/9606.ENSP00000300055 | Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a r [...] |
| PEX11A protein network | https://string-db.org/network/9606.ENSP00000300056 | Peroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By simi [...] |
| MESP1 protein network | https://string-db.org/network/9606.ENSP00000300057 | Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of th [...] |
| ANPEP protein network | https://string-db.org/network/9606.ENSP00000300060 | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved i [...] |
| SCNN1G protein network | https://string-db.org/network/9606.ENSP00000300061 | Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...] |
| RBPMS2 protein network | https://string-db.org/network/9606.ENSP00000300069 | RNA-binding protein with multiple splicing 2; Contributes to the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system. Binds NOG mRNA. Mediates an inc [...] |
| GLYATL1 protein network | https://string-db.org/network/9606.ENSP00000300079 | Glycine N-acyltransferase-like protein 1; Acyltransferase which transfers an acyl group to the N- terminus of glutamine. Can use phenylacetyl-CoA as an acyl donor; Belongs to the glycine N-acyltr [...] |
| TERF2IP protein network | https://string-db.org/network/9606.ENSP00000300086 | Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protecti [...] |
| DCTN5 protein network | https://string-db.org/network/9606.ENSP00000300087 | Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily |
| PLK1 protein network | https://string-db.org/network/9606.ENSP00000300093 | Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome matura [...] |
| GPR182 protein network | https://string-db.org/network/9606.ENSP00000300098 | G-protein coupled receptor 182; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ZBTB39 protein network | https://string-db.org/network/9606.ENSP00000300101 | Zinc finger and BTB domain-containing protein 39; May be involved in transcriptional regulation; BTB domain containing |
| CACNG2 protein network | https://string-db.org/network/9606.ENSP00000300105 | Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane a [...] |
| CLPX protein network | https://string-db.org/network/9606.ENSP00000300107 | ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradati [...] |
| CHP2 protein network | https://string-db.org/network/9606.ENSP00000300113 | Calcineurin B homologous protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in [...] |
| OR4D6 protein network | https://string-db.org/network/9606.ENSP00000300127 | Olfactory receptor 4D6; Odorant receptor; Olfactory receptors, family 4 |
| TMEM194A protein network | https://string-db.org/network/9606.ENSP00000300128 | Transmembrane protein 194A |
| NAB2 protein network | https://string-db.org/network/9606.ENSP00000300131 | NGFI-A-binding protein 2; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity); Belongs to the NAB family |
| STAT6 protein network | https://string-db.org/network/9606.ENSP00000300134 | Signal transducer and activator of transcription 6; Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated [...] |
| XRCC6BP1 protein network | https://string-db.org/network/9606.ENSP00000300145 | Mitochondrial inner membrane protease ATP23 homolog; XRCC6 binding protein 1; Belongs to the peptidase M76 family |
| PATL1 protein network | https://string-db.org/network/9606.ENSP00000300146 | Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and [...] |
| MRPL16 protein network | https://string-db.org/network/9606.ENSP00000300151 | Mitochondrial ribosomal protein L16; Belongs to the universal ribosomal protein uL16 family |
| SCG5 protein network | https://string-db.org/network/9606.ENSP00000300175 | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticul [...] |
| AGFG2 protein network | https://string-db.org/network/9606.ENSP00000300176 | Arf-GAP domain and FG repeat-containing protein 2; ArfGAP with FG repeats 2; ArfGAPs |
| NYAP1 protein network | https://string-db.org/network/9606.ENSP00000300179 | Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesi [...] |
| TSC22D4 protein network | https://string-db.org/network/9606.ENSP00000300181 | TSC22 domain family protein 4; Transcriptional repressor |
| MS4A6E protein network | https://string-db.org/network/9606.ENSP00000300182 | Membrane-spanning 4-domains subfamily A member 6E; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| MS4A7 protein network | https://string-db.org/network/9606.ENSP00000300184 | Membrane-spanning 4-domains subfamily A member 7; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family |
| MS4A5 protein network | https://string-db.org/network/9606.ENSP00000300190 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| METTL21B protein network | https://string-db.org/network/9606.ENSP00000300209 | EEF1A lysine methyltransferase 3; Protein-lysine methyltransferase that selectively methylates EEF1A1 and EEF1A2 at 'Lys-165' in an aminoacyl-tRNA and GTP-dependent manner. EEF1A1 methylation by [...] |
| CCNDBP1 protein network | https://string-db.org/network/9606.ENSP00000300213 | Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and b [...] |
| EPB42 protein network | https://string-db.org/network/9606.ENSP00000300215 | Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutami [...] |
| MS4A8 protein network | https://string-db.org/network/9606.ENSP00000300226 | Membrane-spanning 4-domains subfamily A member 8; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| MAP1A protein network | https://string-db.org/network/9606.ENSP00000300231 | Microtubule-associated protein 1A; Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements |
| MAPRE2 protein network | https://string-db.org/network/9606.ENSP00000300249 | Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a [...] |
| EVA1C protein network | https://string-db.org/network/9606.ENSP00000300255 | Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family |
| TCP10L protein network | https://string-db.org/network/9606.ENSP00000300258 | T-complex protein 10A homolog 2; May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells |
| CKMT1B protein network | https://string-db.org/network/9606.ENSP00000300283 | Creatine kinase, mitochondrial 1B; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in [...] |
| PDIA3 protein network | https://string-db.org/network/9606.ENSP00000300289 | Protein disulfide-isomerase A3; Protein disulfide isomerase family A member 3; Belongs to the protein disulfide isomerase family |
| NUDT21 protein network | https://string-db.org/network/9606.ENSP00000300291 | Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 o [...] |
| NAT16 protein network | https://string-db.org/network/9606.ENSP00000300303 | Probable N-acetyltransferase 16; Probable N-acetyltransferase. Shows only trace activity toward L-His and no N-acetyltransferase activity toward other amino acids. The physiological substrate of [...] |
| RUNX1 protein network | https://string-db.org/network/9606.ENSP00000300305 | Runt-related transcription factor 1; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor en [...] |
| TPX2 protein network | https://string-db.org/network/9606.ENSP00000300403 | Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or [...] |
| B4GALNT2 protein network | https://string-db.org/network/9606.ENSP00000300404 | Beta-1,4 N-acetylgalactosaminyltransferase 2; Involved in the synthesis of the Sd(a) antigen (Sia- alpha2,3-[GalNAc-beta1,4]Gal-beta1,4-GlcNAc), a carbohydrate determinant expressed on erythrocyt [...] |
| SNRPD1 protein network | https://string-db.org/network/9606.ENSP00000300413 | Small nuclear ribonucleoprotein Sm D1; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an im [...] |
| TMEM92 protein network | https://string-db.org/network/9606.ENSP00000300433 | Transmembrane protein 92 |
| COQ4 protein network | https://string-db.org/network/9606.ENSP00000300452 | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzy [...] |
| SLC27A4 protein network | https://string-db.org/network/9606.ENSP00000300456 | Long-chain fatty acid transport protein 4; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intes [...] |
| TBC1D21 protein network | https://string-db.org/network/9606.ENSP00000300504 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possib [...] |
| COL6A2 protein network | https://string-db.org/network/9606.ENSP00000300527 | Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein; Collagens |
| PRR15L protein network | https://string-db.org/network/9606.ENSP00000300557 | Proline-rich protein 15-like protein; Proline rich 15 like; Belongs to the PRR15 family |
| GPRC5B protein network | https://string-db.org/network/9606.ENSP00000300571 | G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein s [...] |
| CRK protein network | https://string-db.org/network/9606.ENSP00000300574 | Adapter molecule crk; Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner [...] |
| C16orf92 protein network | https://string-db.org/network/9606.ENSP00000300575 | Uncharacterized protein C16orf92; Chromosome 16 open reading frame 92 |
| TBC1D2B protein network | https://string-db.org/network/9606.ENSP00000300584 | TBC1 domain family member 2B; May act as a GTPase-activating protein |
| NOD2 protein network | https://string-db.org/network/9606.ENSP00000300589 | Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds th [...] |
| LOXHD1 protein network | https://string-db.org/network/9606.ENSP00000300591 | Lipoxygenase homology domain-containing protein 1; Involved in hearing. Required for normal function of hair cells in the inner ear (By similarity); Deafness associated genes |
| HDHD2 protein network | https://string-db.org/network/9606.ENSP00000300605 | Haloacid dehalogenase like hydrolase domain containing 2 |
| ZNF91 protein network | https://string-db.org/network/9606.ENSP00000300619 | Zinc finger protein 91; Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting [...] |
| GCN1L1 protein network | https://string-db.org/network/9606.ENSP00000300648 | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating [...] |
| RNF214 protein network | https://string-db.org/network/9606.ENSP00000300650 | Ring finger protein 214 |
| MED1 protein network | https://string-db.org/network/9606.ENSP00000300651 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| PGAP3 protein network | https://string-db.org/network/9606.ENSP00000300658 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 [...] |
| NFATC3 protein network | https://string-db.org/network/9606.ENSP00000300659 | Nuclear factor of activated T-cells, cytoplasmic 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the ind [...] |
| ATP5L protein network | https://string-db.org/network/9606.ENSP00000300688 | ATP synthase subunit g, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...] |
| CD3D protein network | https://string-db.org/network/9606.ENSP00000300692 | T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cel [...] |
| ENTHD2 protein network | https://string-db.org/network/9606.ENSP00000300714 | AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network |
| RRM1 protein network | https://string-db.org/network/9606.ENSP00000300738 | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides |
| TRIM68 protein network | https://string-db.org/network/9606.ENSP00000300747 | E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity; Ring finger proteins |
| OR51B5 protein network | https://string-db.org/network/9606.ENSP00000300773 | Olfactory receptor 51B5; Odorant receptor; Olfactory receptors, family 51 |
| OR51Q1 protein network | https://string-db.org/network/9606.ENSP00000300778 | Olfactory receptor 51Q1; Odorant receptor; Olfactory receptors, family 51 |
| FN3K protein network | https://string-db.org/network/9606.ENSP00000300784 | Fructosamine-3-kinase; May initiate a process leading to the deglycation of fructoselysine and of glycated proteins. May play a role in the phosphorylation of 1-deoxy-1-morpholinofructose (DMF), [...] |
| ZNF428 protein network | https://string-db.org/network/9606.ENSP00000300811 | Zinc finger protein 428; Zinc fingers C2H2-type |
| ZNF646 protein network | https://string-db.org/network/9606.ENSP00000300850 | Zinc finger protein 646; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF267 protein network | https://string-db.org/network/9606.ENSP00000300870 | Zinc finger protein 267; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GNG8 protein network | https://string-db.org/network/9606.ENSP00000300873 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| USP32 protein network | https://string-db.org/network/9606.ENSP00000300896 | Ubiquitin specific peptidase 32; Belongs to the peptidase C19 family |
| CA4 protein network | https://string-db.org/network/9606.ENSP00000300900 | Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload re [...] |
| RAB8A protein network | https://string-db.org/network/9606.ENSP00000300935 | Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| MIDN protein network | https://string-db.org/network/9606.ENSP00000300952 | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin [...] |
| PCSK4 protein network | https://string-db.org/network/9606.ENSP00000300954 | Proprotein convertase subtilisin/kexin type 4; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (B [...] |
| JSRP1 protein network | https://string-db.org/network/9606.ENSP00000300961 | Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage- sensitive calcium channel CACNA1S. EC [...] |
| KLHL26 protein network | https://string-db.org/network/9606.ENSP00000300976 | Kelch-like protein 26; Kelch like family member 26; BTB domain containing |
| MVD protein network | https://string-db.org/network/9606.ENSP00000301012 | Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes |
| PIEZO1 protein network | https://string-db.org/network/9606.ENSP00000301015 | Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relations [...] |
| CDT1 protein network | https://string-db.org/network/9606.ENSP00000301019 | DNA replication factor Cdt1; Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin re [...] |
| TRAPPC2L protein network | https://string-db.org/network/9606.ENSP00000301021 | Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. Sedlin subfami [...] |
| ANKRD11 protein network | https://string-db.org/network/9606.ENSP00000301030 | Ankyrin repeat domain-containing protein 11; Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylase [...] |
| SGK494 protein network | https://string-db.org/network/9606.ENSP00000301037 | Uncharacterized serine/threonine-protein kinase SgK494; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| PROCA1 protein network | https://string-db.org/network/9606.ENSP00000301039 | Protein interacting with cyclin A1; Belongs to the PROCA1 family |
| LALBA protein network | https://string-db.org/network/9606.ENSP00000301046 | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme [...] |
| CACNB3 protein network | https://string-db.org/network/9606.ENSP00000301050 | Voltage-dependent L-type calcium channel subunit beta-3; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...] |
| TP53I13 protein network | https://string-db.org/network/9606.ENSP00000301057 | Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed |
| WNT10B protein network | https://string-db.org/network/9606.ENSP00000301061 | Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and [...] |
| KMT2D protein network | https://string-db.org/network/9606.ENSP00000301067 | Histone-lysine N-methyltransferase 2D; Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a [...] |
| RHEBL1 protein network | https://string-db.org/network/9606.ENSP00000301068 | GTPase RhebL1; Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downst [...] |
| TUBA1A protein network | https://string-db.org/network/9606.ENSP00000301071 | Tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| TUBA1C protein network | https://string-db.org/network/9606.ENSP00000301072 | Tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| CYP2A6 protein network | https://string-db.org/network/9606.ENSP00000301141 | Cytochrome P450 2A6; Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation [...] |
| CYP2A7 protein network | https://string-db.org/network/9606.ENSP00000301146 | Cytochrome P450 2A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| GPD1 protein network | https://string-db.org/network/9606.ENSP00000301149 | Glycerol-3-phosphate dehydrogenase 1; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family |
| LIN37 protein network | https://string-db.org/network/9606.ENSP00000301159 | Protein lin-37 homolog; Lin-37 DREAM MuvB core complex component |
| PRODH2 protein network | https://string-db.org/network/9606.ENSP00000301175 | Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone- 10 as the terminal electron acceptor. Can a [...] |
| AXL protein network | https://string-db.org/network/9606.ENSP00000301178 | Tyrosine-protein kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating [...] |
| DIP2B protein network | https://string-db.org/network/9606.ENSP00000301180 | Disco interacting protein 2 homolog B |
| ANKRD33 protein network | https://string-db.org/network/9606.ENSP00000301190 | Photoreceptor ankyrin repeat protein; Acts as a transcriptional repressor for CRX-activated photoreceptor gene regulation; Ankyrin repeat domain containing |
| CDC42EP5 protein network | https://string-db.org/network/9606.ENSP00000301200 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...] |
| LAIR2 protein network | https://string-db.org/network/9606.ENSP00000301202 | Leukocyte associated immunoglobulin like receptor 2; CD molecules |
| TMEM145 protein network | https://string-db.org/network/9606.ENSP00000301204 | Transmembrane protein 145 |
| ZNF526 protein network | https://string-db.org/network/9606.ENSP00000301215 | Zinc finger protein 526; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PPP1R14A protein network | https://string-db.org/network/9606.ENSP00000301242 | Protein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylatio [...] |
| SPINT2 protein network | https://string-db.org/network/9606.ENSP00000301244 | Kunitz-type protease inhibitor 2; Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa |
| C19orf33 protein network | https://string-db.org/network/9606.ENSP00000301246 | Immortalization up-regulated protein; Chromosome 19 open reading frame 33 |
| PSCA protein network | https://string-db.org/network/9606.ENSP00000301258 | Prostate stem cell antigen; May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro; LY6/PLAUR domain containing |
| LY6D protein network | https://string-db.org/network/9606.ENSP00000301263 | Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification; LY6/PL [...] |
| TMIGD2 protein network | https://string-db.org/network/9606.ENSP00000301272 | Transmembrane and immunoglobulin domain-containing protein 2; Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T- cells in the [...] |
| CHAF1A protein network | https://string-db.org/network/9606.ENSP00000301280 | Chromatin assembly factor 1 subunit A; Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto repl [...] |
| UBXN6 protein network | https://string-db.org/network/9606.ENSP00000301281 | UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular process [...] |
| PLIN4 protein network | https://string-db.org/network/9606.ENSP00000301286 | Perilipin-4; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets (By similarity); Belongs to the perilipin fa [...] |
| NLRP4 protein network | https://string-db.org/network/9606.ENSP00000301295 | NACHT, LRR and PYD domains-containing protein 4; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound rece [...] |
| SLC39A4 protein network | https://string-db.org/network/9606.ENSP00000301305 | Zinc transporter ZIP4; Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity); Solute carriers |
| ZNF582 protein network | https://string-db.org/network/9606.ENSP00000301310 | Zinc finger protein 582; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZFP28 protein network | https://string-db.org/network/9606.ENSP00000301318 | Zinc finger protein 28 homolog; May be involved in transcriptional regulation. May have a role in embryonic development; Zinc fingers C2H2-type |
| MFSD3 protein network | https://string-db.org/network/9606.ENSP00000301327 | Major facilitator superfamily domain containing 3 |
| GLOD4 protein network | https://string-db.org/network/9606.ENSP00000301329 | Glyoxalase domain containing 4 |
| KIFC2 protein network | https://string-db.org/network/9606.ENSP00000301332 | Kinesin-like protein KIFC2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendr [...] |
| RILP protein network | https://string-db.org/network/9606.ENSP00000301336 | Rab-interacting lysosomal protein; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induce [...] |
| TSR1 protein network | https://string-db.org/network/9606.ENSP00000301364 | Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus |
| TRPV3 protein network | https://string-db.org/network/9606.ENSP00000301365 | Transient receptor potential cation channel subfamily V member 3; Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and s [...] |
| CYB5D2 protein network | https://string-db.org/network/9606.ENSP00000301391 | Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation; Membrane associated progesterone receptor family |
| PELP1 protein network | https://string-db.org/network/9606.ENSP00000301396 | Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence- specific transcript [...] |
| ZNF577 protein network | https://string-db.org/network/9606.ENSP00000301399 | Zinc finger protein 577; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CGB1 protein network | https://string-db.org/network/9606.ENSP00000301407 | Chorionic gonadotropin beta subunit 1 |
| CGB5 protein network | https://string-db.org/network/9606.ENSP00000301408 | Chorionic gonadotropin beta subunit 5 |
| KLK1 protein network | https://string-db.org/network/9606.ENSP00000301420 | Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily |
| ACER1 protein network | https://string-db.org/network/9606.ENSP00000301452 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisome [...] |
| SLC25A23 protein network | https://string-db.org/network/9606.ENSP00000301454 | Calcium-binding mitochondrial carrier protein SCaMC-3; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mi [...] |
| ANGPTL4 protein network | https://string-db.org/network/9606.ENSP00000301455 | Angiopoietin-related protein 4; Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, [...] |
| NDUFA7 protein network | https://string-db.org/network/9606.ENSP00000301457 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| CD320 protein network | https://string-db.org/network/9606.ENSP00000301458 | CD320 antigen; Receptor for transcobalamin saturated with cobalamin (TCbl). Plays an important role in cobalamin uptake. Plasma membrane protein that is expressed on follicular dendritic cells (F [...] |
| RCOR2 protein network | https://string-db.org/network/9606.ENSP00000301459 | REST corepressor 2; May act as a component of a corepressor complex that represses transcription; Myb/SANT domain containing |
| SPRYD3 protein network | https://string-db.org/network/9606.ENSP00000301463 | SPRY domain containing 3 |
| IGFBP6 protein network | https://string-db.org/network/9606.ENSP00000301464 | Insulin-like growth factor-binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...] |
| SOAT2 protein network | https://string-db.org/network/9606.ENSP00000301466 | Sterol O-acyltransferase 2; Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl e [...] |
| ZNF560 protein network | https://string-db.org/network/9606.ENSP00000301480 | Zinc finger protein 560; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CDK2AP2 protein network | https://string-db.org/network/9606.ENSP00000301488 | Cyclin-dependent kinase 2-associated protein 2; Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs [...] |
| PRDX2 protein network | https://string-db.org/network/9606.ENSP00000301522 | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...] |
| OR8J3 protein network | https://string-db.org/network/9606.ENSP00000301529 | Olfactory receptor 8J3; Odorant receptor; Olfactory receptors, family 8 |
| OR5I1 protein network | https://string-db.org/network/9606.ENSP00000301532 | Olfactory receptor 5I1; Odorant receptor; Olfactory receptors, family 5 |
| ZNF443 protein network | https://string-db.org/network/9606.ENSP00000301547 | Zinc finger protein 443; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ICT1 protein network | https://string-db.org/network/9606.ENSP00000301585 | Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that [...] |
| ATP5H protein network | https://string-db.org/network/9606.ENSP00000301587 | ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...] |
| TMEM88 protein network | https://string-db.org/network/9606.ENSP00000301599 | Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitm [...] |
| EVPL protein network | https://string-db.org/network/9606.ENSP00000301607 | Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments; Plakins |
| BIRC5 protein network | https://string-db.org/network/9606.ENSP00000301633 | Baculoviral IAP repeat containing 5 |
| TK1 protein network | https://string-db.org/network/9606.ENSP00000301634 | Thymidine kinase, cytosolic; Thymidine kinase 1; Belongs to the thymidine kinase family |
| CYP7A1 protein network | https://string-db.org/network/9606.ENSP00000301645 | Cholesterol 7-alpha-monooxygenase; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important [...] |
| KRT16 protein network | https://string-db.org/network/9606.ENSP00000301653 | Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some infl [...] |
| KRT27 protein network | https://string-db.org/network/9606.ENSP00000301656 | Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) |
| GSDMA protein network | https://string-db.org/network/9606.ENSP00000301659 | Gasdermin-A; May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidyl [...] |
| GHDC protein network | https://string-db.org/network/9606.ENSP00000301671 | GH3 domain-containing protein; GH3 domain containing; Belongs to the GH3 family |
| SOST protein network | https://string-db.org/network/9606.ENSP00000301691 | Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; DAN family |
| PRR25 protein network | https://string-db.org/network/9606.ENSP00000301698 | Proline-rich protein 25; Proline rich 25 |
| UNKL protein network | https://string-db.org/network/9606.ENSP00000301712 | Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by RAC1. Ubiquitination is directed towards itself and possibly other subst [...] |
| E4F1 protein network | https://string-db.org/network/9606.ENSP00000301727 | Transcription factor E4F1; May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival a [...] |
| ECI1 protein network | https://string-db.org/network/9606.ENSP00000301729 | Enoyl-CoA delta isomerase 1, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species |
| ABCA3 protein network | https://string-db.org/network/9606.ENSP00000301732 | ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol; Belongs to the ABC transporter s [...] |
| KCTD5 protein network | https://string-db.org/network/9606.ENSP00000301738 | BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB [...] |
| SRRM2 protein network | https://string-db.org/network/9606.ENSP00000301740 | Serine/arginine repetitive matrix protein 2; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so [...] |
| ZNF597 protein network | https://string-db.org/network/9606.ENSP00000301744 | Zinc finger protein 597; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SDHAF2 protein network | https://string-db.org/network/9606.ENSP00000301761 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...] |
| DDB1 protein network | https://string-db.org/network/9606.ENSP00000301764 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA dam [...] |
| VPS37C protein network | https://string-db.org/network/9606.ENSP00000301765 | Vacuolar protein sorting-associated protein 37C; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...] |
| HNRNPUL2 protein network | https://string-db.org/network/9606.ENSP00000301785 | Heterogeneous nuclear ribonucleoprotein U like 2 |
| POLR2G protein network | https://string-db.org/network/9606.ENSP00000301788 | DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| HRASLS5 protein network | https://string-db.org/network/9606.ENSP00000301790 | Ca(2+)-independent N-acyltransferase; Catalyzes N-acylation of phosphatidylethanolamine (PE) to generate N-Acylphosphatidylethanolamine (NAPE) a precursor of bioactive N-acylethanolamines, includ [...] |
| ENTPD3 protein network | https://string-db.org/network/9606.ENSP00000301825 | Ectonucleoside triphosphate diphosphohydrolase 3; Has a threefold preference for the hydrolysis of ATP over ADP |
| ULK4 protein network | https://string-db.org/network/9606.ENSP00000301831 | Serine/threonine-protein kinase ULK4; May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as c [...] |
| FADD protein network | https://string-db.org/network/9606.ENSP00000301838 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-ind [...] |
| LTBP3 protein network | https://string-db.org/network/9606.ENSP00000301873 | Latent-transforming growth factor beta-binding protein 3; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical role [...] |
| BATF2 protein network | https://string-db.org/network/9606.ENSP00000301887 | Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, par [...] |
| SLC22A11 protein network | https://string-db.org/network/9606.ENSP00000301891 | Solute carrier family 22 member 11; Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds; Solute carriers |
| C11orf85 protein network | https://string-db.org/network/9606.ENSP00000301896 | Membrane-anchored junction protein; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and s [...] |
| SCARA3 protein network | https://string-db.org/network/9606.ENSP00000301904 | Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation; Scavenger receptors |
| PNOC protein network | https://string-db.org/network/9606.ENSP00000301908 | Prepronociceptin; Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neur [...] |
| GPR25 protein network | https://string-db.org/network/9606.ENSP00000301917 | Probable G-protein coupled receptor 25; Orphan receptor; G protein-coupled receptors, Class A orphans |
| SOX7 protein network | https://string-db.org/network/9606.ENSP00000301921 | Transcription factor SOX-7; Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further diffe [...] |
| TRIM35 protein network | https://string-db.org/network/9606.ENSP00000301924 | Tripartite motif-containing protein 35; Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth. Involved in the [...] |
| TMEM256 protein network | https://string-db.org/network/9606.ENSP00000301939 | Transmembrane protein 256 |
| ANTXR1 protein network | https://string-db.org/network/9606.ENSP00000301945 | Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collage [...] |
| ACSM1 protein network | https://string-db.org/network/9606.ENSP00000301956 | Acyl-coenzyme A synthetase ACSM1, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspon [...] |
| USP42 protein network | https://string-db.org/network/9606.ENSP00000301962 | Ubiquitin carboxyl-terminal hydrolase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis; Ubiquitin specific peptidases |
| MYRIP protein network | https://string-db.org/network/9606.ENSP00000301972 | Rab effector MyRIP; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicl [...] |
| MFF protein network | https://string-db.org/network/9606.ENSP00000302037 | Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mito [...] |
| RNASE6 protein network | https://string-db.org/network/9606.ENSP00000302046 | Ribonuclease K6; May have a role in host defense; Ribonuclease A family |
| ECEL1 protein network | https://string-db.org/network/9606.ENSP00000302051 | Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; M13 metallopeptidases |
| OR5AU1 protein network | https://string-db.org/network/9606.ENSP00000302057 | Olfactory receptor 5AU1; Odorant receptor; Olfactory receptors, family 5 |
| C3AR1 protein network | https://string-db.org/network/9606.ENSP00000302079 | C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion p [...] |
| LGALS4 protein network | https://string-db.org/network/9606.ENSP00000302100 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins |
| CRYGA protein network | https://string-db.org/network/9606.ENSP00000302105 | Gamma-crystallin A; Crystallins are the dominant structural components of the vertebrate eye lens |
| PANK1 protein network | https://string-db.org/network/9606.ENSP00000302108 | Pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration; Belongs to the type II pantothenate kinase family |
| MGMT protein network | https://string-db.org/network/9606.ENSP00000302111 | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the [...] |
| PRELID1 protein network | https://string-db.org/network/9606.ENSP00000302114 | PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In [...] |
| TRIM8 protein network | https://string-db.org/network/9606.ENSP00000302120 | Probable E3 ubiquitin-protein ligase TRIM8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1; Belongs to the TRIM/RBCC family |
| TMEM154 protein network | https://string-db.org/network/9606.ENSP00000302144 | Transmembrane protein 154 |
| PRL protein network | https://string-db.org/network/9606.ENSP00000302150 | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family |
| LSM3 protein network | https://string-db.org/network/9606.ENSP00000302160 | U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA; Belongs to the snRNP Sm proteins family |
| MBOAT2 protein network | https://string-db.org/network/9606.ENSP00000302177 | Lysophospholipid acyltransferase 2; Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine ( [...] |
| NHLH1 protein network | https://string-db.org/network/9606.ENSP00000302189 | Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system; Basic helix-loop-helix p [...] |
| ATP6V1G2 protein network | https://string-db.org/network/9606.ENSP00000302194 | V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...] |
| OR10V1 protein network | https://string-db.org/network/9606.ENSP00000302199 | Olfactory receptor 10V1; Odorant receptor; Olfactory receptors, family 10 |
| C2orf15 protein network | https://string-db.org/network/9606.ENSP00000302202 | Uncharacterized protein C2orf15; Chromosome 2 open reading frame 15 |
| ATOH1 protein network | https://string-db.org/network/9606.ENSP00000302216 | Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator o [...] |
| ZNF25 protein network | https://string-db.org/network/9606.ENSP00000302222 | Zinc finger protein 25; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ALKBH3 protein network | https://string-db.org/network/9606.ENSP00000302232 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1- methyladen [...] |
| CCL11 protein network | https://string-db.org/network/9606.ENSP00000302234 | Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3; Chemokine [...] |
| GBX2 protein network | https://string-db.org/network/9606.ENSP00000302251 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo; HOXL subclass homeoboxes |
| C8orf46 protein network | https://string-db.org/network/9606.ENSP00000302260 | Uncharacterized protein C8orf46; Chromosome 8 open reading frame 46 |
| C1QTNF4 protein network | https://string-db.org/network/9606.ENSP00000302274 | Complement C1q tumor necrosis factor-related protein 4; May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production; C1q an [...] |
| HEXIM2 protein network | https://string-db.org/network/9606.ENSP00000302276 | Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP com [...] |
| EMB protein network | https://string-db.org/network/9606.ENSP00000302289 | Embigin; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additio [...] |
| LGI3 protein network | https://string-db.org/network/9606.ENSP00000302297 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis |
| ZNF396 protein network | https://string-db.org/network/9606.ENSP00000302310 | Zinc finger protein 396; Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors; Belongs to the krueppel C2H2-type zinc-finger protein family |
| RNASE3 protein network | https://string-db.org/network/9606.ENSP00000302324 | Eosinophil cationic protein; Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including [...] |
| PYGO1 protein network | https://string-db.org/network/9606.ENSP00000302327 | Pygopus homolog 1; Involved in signal transduction through the Wnt pathway; PHD finger proteins |
| LDHAL6B protein network | https://string-db.org/network/9606.ENSP00000302393 | Lactate dehydrogenase A like 6B |
| SMR3B protein network | https://string-db.org/network/9606.ENSP00000302400 | Submaxillary gland androgen regulated protein 3B; Belongs to the PROL1/PROL3 family |
| TPST1 protein network | https://string-db.org/network/9606.ENSP00000302413 | Protein-tyrosine sulfotransferase 1; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the pr [...] |
| OR52K1 protein network | https://string-db.org/network/9606.ENSP00000302422 | Olfactory receptor 52K1; Odorant receptor; Olfactory receptors, family 52 |
| OR10G3 protein network | https://string-db.org/network/9606.ENSP00000302437 | Olfactory receptor 10G3; Odorant receptor; Olfactory receptors, family 10 |
| NANP protein network | https://string-db.org/network/9606.ENSP00000302441 | N-acylneuraminate-9-phosphatase; Haloacid dehalogenase like hydrolase domain containing; HAD Asp-based non-protein phosphatases |
| KLF13 protein network | https://string-db.org/network/9606.ENSP00000302456 | Krueppel-like factor 13; Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the [...] |
| HSPB2 protein network | https://string-db.org/network/9606.ENSP00000302476 | Heat shock protein beta-2; May regulate the kinase DMPK; Small heat shock proteins |
| POLR1D protein network | https://string-db.org/network/9606.ENSP00000302478 | DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common co [...] |
| CSDC2 protein network | https://string-db.org/network/9606.ENSP00000302485 | Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'-UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play [...] |
| MAP2K1 protein network | https://string-db.org/network/9606.ENSP00000302486 | Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracel [...] |
| BUB1 protein network | https://string-db.org/network/9606.ENSP00000302530 | Mitotic checkpoint serine/threonine-protein kinase BUB1; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signalin [...] |
| MDM1 protein network | https://string-db.org/network/9606.ENSP00000302537 | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules |
| CXXC5 protein network | https://string-db.org/network/9606.ENSP00000302543 | CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity [...] |
| HOXD4 protein network | https://string-db.org/network/9606.ENSP00000302548 | Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| GLOD5 protein network | https://string-db.org/network/9606.ENSP00000302552 | Glyoxalase domain containing 5; Belongs to the glyoxalase I family |
| HSPBAP1 protein network | https://string-db.org/network/9606.ENSP00000302562 | HSPB1-associated protein 1; May play a role in cellular stress response |
| BCL2L1 protein network | https://string-db.org/network/9606.ENSP00000302564 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and [...] |
| CLEC7A protein network | https://string-db.org/network/9606.ENSP00000302569 | C-type lectin domain family 7 member A; Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria [...] |
| FAM84B protein network | https://string-db.org/network/9606.ENSP00000302578 | Protein FAM84B; Family with sequence similarity 84 member B; Belongs to the FAM84 family |
| SCEL protein network | https://string-db.org/network/9606.ENSP00000302579 | Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sc [...] |
| KBTBD2 protein network | https://string-db.org/network/9606.ENSP00000302586 | Kelch repeat and BTB domain containing 2 |
| FUT9 protein network | https://string-db.org/network/9606.ENSP00000302599 | Alpha-(1,3)-fucosyltransferase 9; Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthes [...] |
| ZNF556 protein network | https://string-db.org/network/9606.ENSP00000302603 | Zinc finger protein 556; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR9I1 protein network | https://string-db.org/network/9606.ENSP00000302606 | Olfactory receptor 9I1; Odorant receptor; Olfactory receptors, family 9 |
| AGXT protein network | https://string-db.org/network/9606.ENSP00000302620 | Alanine-glyoxylate aminotransferase |
| LRG1 protein network | https://string-db.org/network/9606.ENSP00000302621 | Leucine rich alpha-2-glycoprotein 1 |
| AXIN2 protein network | https://string-db.org/network/9606.ENSP00000302625 | Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity) |
| CHSY3 protein network | https://string-db.org/network/9606.ENSP00000302629 | Chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosam [...] |
| ONECUT1 protein network | https://string-db.org/network/9606.ENSP00000302630 | Hepatocyte nuclear factor 6; Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes t [...] |
| UBTF protein network | https://string-db.org/network/9606.ENSP00000302640 | Nucleolar transcription factor 1; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription facto [...] |
| RALGAPA1 protein network | https://string-db.org/network/9606.ENSP00000302647 | Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB |
| NRTN protein network | https://string-db.org/network/9606.ENSP00000302648 | Neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopo [...] |
| ABHD15 protein network | https://string-db.org/network/9606.ENSP00000302657 | Protein ABHD15; Abhydrolase domain containing 15 |
| IGF1 protein network | https://string-db.org/network/9606.ENSP00000302665 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be [...] |
| GPR22 protein network | https://string-db.org/network/9606.ENSP00000302676 | Probable G-protein coupled receptor 22; Orphan receptor; G protein-coupled receptors, Class A orphans |
| MUC17 protein network | https://string-db.org/network/9606.ENSP00000302716 | Mucin-17; Probably plays a role in maintaining homeostasis on mucosal surfaces; Mucins |
| KCNAB3 protein network | https://string-db.org/network/9606.ENSP00000302719 | Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5; Aldo [...] |
| INSL5 protein network | https://string-db.org/network/9606.ENSP00000302724 | Insulin-like peptide INSL5; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this recept [...] |
| GUSB protein network | https://string-db.org/network/9606.ENSP00000302728 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family |
| FOXD4L1 protein network | https://string-db.org/network/9606.ENSP00000302756 | Forkhead box D4 like 1 |
| PAIP1 protein network | https://string-db.org/network/9606.ENSP00000302768 | Polyadenylate-binding protein-interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is medi [...] |
| ZNF296 protein network | https://string-db.org/network/9606.ENSP00000302770 | Zinc finger protein 296; May be a transcriptional corepressor with KLF4; Zinc fingers C2H2-type |
| TRAPPC1 protein network | https://string-db.org/network/9606.ENSP00000302783 | Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET5 subfamily |
| XPO6 protein network | https://string-db.org/network/9606.ENSP00000302790 | Exportin-6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells; Exportins |
| TRMT61B protein network | https://string-db.org/network/9606.ENSP00000302801 | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial; Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including [...] |
| DDI1 protein network | https://string-db.org/network/9606.ENSP00000302805 | Protein DDI1 homolog 1; Probable aspartic protease |
| MTNR1A protein network | https://string-db.org/network/9606.ENSP00000302811 | Melatonin receptor type 1A; High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis tox [...] |
| OTP protein network | https://string-db.org/network/9606.ENSP00000302814 | Homeobox protein orthopedia; Probably involved in the differentiation of hypothalamic neuroendocrine cells; Belongs to the paired homeobox family. Bicoid subfamily |
| MAEA protein network | https://string-db.org/network/9606.ENSP00000302830 | Macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in co [...] |
| GIMAP1 protein network | https://string-db.org/network/9606.ENSP00000302833 | GTPase IMAP family member 1; May regulate lymphocyte survival. Required for normal levels of mature T-lymphocytes and mature B-cells (By similarity); GTPases, IMAP |
| HOXC9 protein network | https://string-db.org/network/9606.ENSP00000302836 | Homeobox protein Hox-C9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| DNAJC18 protein network | https://string-db.org/network/9606.ENSP00000302843 | DnaJ heat shock protein family member C18 |
| PTGER4 protein network | https://string-db.org/network/9606.ENSP00000302846 | Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on [...] |
| SLC23A1 protein network | https://string-db.org/network/9606.ENSP00000302851 | Solute carrier family 23 member 1; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate; Solute carriers |
| ZNF280A protein network | https://string-db.org/network/9606.ENSP00000302855 | Zinc finger protein 280A; May function as a transcription factor |
| OR1L3 protein network | https://string-db.org/network/9606.ENSP00000302863 | Olfactory receptor 1L3; Odorant receptor; Olfactory receptors, family 1 |
| OR7G3 protein network | https://string-db.org/network/9606.ENSP00000302867 | Olfactory receptor 7G3; Odorant receptor; Olfactory receptors, family 7 |
| PA2G4 protein network | https://string-db.org/network/9606.ENSP00000302886 | Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) an [...] |
| ARAP2 protein network | https://string-db.org/network/9606.ENSP00000302895 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeli [...] |
| RPS9 protein network | https://string-db.org/network/9606.ENSP00000302896 | Ribosomal protein S9 |
| AURKC protein network | https://string-db.org/network/9606.ENSP00000302898 | Aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions a [...] |
| SH3D19 protein network | https://string-db.org/network/9606.ENSP00000302913 | SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced [...] |
| C11orf40 protein network | https://string-db.org/network/9606.ENSP00000302918 | Putative uncharacterized protein C11orf40; Chromosome 11 open reading frame 40 |
| IL17D protein network | https://string-db.org/network/9606.ENSP00000302924 | Interleukin-17D; Induces expression of IL6, CXCL8/IL8, and CSF2/GM-CSF from endothelial cells; Interleukins |
| IL16 protein network | https://string-db.org/network/9606.ENSP00000302935 | Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyt [...] |
| DYNLRB2 protein network | https://string-db.org/network/9606.ENSP00000302936 | Dynein light chain roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and [...] |
| WFDC13 protein network | https://string-db.org/network/9606.ENSP00000302938 | WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing |
| HSPA4 protein network | https://string-db.org/network/9606.ENSP00000302961 | Heat shock protein family A member 4; Belongs to the heat shock protein 70 family |
| HDAC3 protein network | https://string-db.org/network/9606.ENSP00000302967 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deace [...] |
| SPRY3 protein network | https://string-db.org/network/9606.ENSP00000302978 | Protein sprouty homolog 3; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Pseudoautosomal region 2 |
| ZRSR2 protein network | https://string-db.org/network/9606.ENSP00000303015 | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with t [...] |
| TM4SF20 protein network | https://string-db.org/network/9606.ENSP00000303028 | Transmembrane 4 L6 family member 20; Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen sy [...] |
| AFAP1L2 protein network | https://string-db.org/network/9606.ENSP00000303042 | Actin filament-associated protein 1-like 2; May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation; Pleckstrin homol [...] |
| PPIC protein network | https://string-db.org/network/9606.ENSP00000303057 | Peptidyl-prolyl cis-trans isomerase C; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin peptidylp [...] |
| CEP120 protein network | https://string-db.org/network/9606.ENSP00000303058 | Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nucl [...] |
| XAGE3 protein network | https://string-db.org/network/9606.ENSP00000303061 | X antigen family member 3 |
| SCGB1D1 protein network | https://string-db.org/network/9606.ENSP00000303070 | Secretoglobin family 1D member 1; May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of [...] |
| OR5B2 protein network | https://string-db.org/network/9606.ENSP00000303076 | Olfactory receptor 5B2; Odorant receptor; Olfactory receptors, family 5 |
| GOT1L1 protein network | https://string-db.org/network/9606.ENSP00000303077 | Putative aspartate aminotransferase, cytoplasmic 2; Glutamic-oxaloacetic transaminase 1 like 1 |
| OR5A1 protein network | https://string-db.org/network/9606.ENSP00000303096 | Olfactory receptor 5A1; Odorant receptor; Olfactory receptors, family 5 |
| OR5AP2 protein network | https://string-db.org/network/9606.ENSP00000303111 | Olfactory receptor 5AP2; Odorant receptor; Olfactory receptors, family 5 |
| VAT1L protein network | https://string-db.org/network/9606.ENSP00000303129 | Synaptic vesicle membrane protein VAT-1 homolog-like; Vesicle amine transport 1 like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily |
| TMED10 protein network | https://string-db.org/network/9606.ENSP00000303145 | Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side [...] |
| MAT2A protein network | https://string-db.org/network/9606.ENSP00000303147 | S-adenosylmethionine synthase isoform type-2; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: [...] |
| TMEM37 protein network | https://string-db.org/network/9606.ENSP00000303148 | Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state. Modulates calcium current when coexpressed with CACNA1G (By simila [...] |
| GPR27 protein network | https://string-db.org/network/9606.ENSP00000303149 | Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G- protein coupled receptor; G protein-coupled receptors, Class A orphans |
| OR1B1 protein network | https://string-db.org/network/9606.ENSP00000303151 | Olfactory receptor 1B1; Odorant receptor; Olfactory receptors, family 1 |
| COL22A1 protein network | https://string-db.org/network/9606.ENSP00000303153 | Collagen alpha-1(XXII) chain; Acts as a cell adhesion ligand for skin epithelial cells and fibroblasts; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family |
| CCDC8 protein network | https://string-db.org/network/9606.ENSP00000303158 | Coiled-coil domain-containing protein 8; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates mic [...] |
| UGT1A6 protein network | https://string-db.org/network/9606.ENSP00000303174 | UDP-glucuronosyltransferase 1-6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity [...] |
| RGL1 protein network | https://string-db.org/network/9606.ENSP00000303192 | Ral guanine nucleotide dissociation stimulator-like 1; Probable guanine nucleotide exchange factor |
| REG1B protein network | https://string-db.org/network/9606.ENSP00000303206 | Lithostathine-1-beta; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration; C-typ [...] |
| PCSK9 protein network | https://string-db.org/network/9606.ENSP00000303208 | Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein rece [...] |
| ACHE protein network | https://string-db.org/network/9606.ENSP00000303211 | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis; Belongs t [...] |
| SEMA3E protein network | https://string-db.org/network/9606.ENSP00000303212 | Semaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promote [...] |
| MTCH2 protein network | https://string-db.org/network/9606.ENSP00000303222 | Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization; Solute carriers |
| IL12A protein network | https://string-db.org/network/9606.ENSP00000303231 | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the product [...] |
| ACOT12 protein network | https://string-db.org/network/9606.ENSP00000303246 | Acyl-coenzyme A thioesterase 12; Hydrolyzes acetyl-CoA to acetate and CoA; Acyl-CoA thioesterases |
| ZNF804A protein network | https://string-db.org/network/9606.ENSP00000303252 | Zinc finger protein 804A |
| RNASE2 protein network | https://string-db.org/network/9606.ENSP00000303276 | Non-secretory ribonuclease; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for de [...] |
| JUNB protein network | https://string-db.org/network/9606.ENSP00000303315 | Transcription factor jun-B; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'; Belongs to the bZIP [...] |
| TACR3 protein network | https://string-db.org/network/9606.ENSP00000303325 | Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messeng [...] |
| DCXR protein network | https://string-db.org/network/9606.ENSP00000303356 | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose meta [...] |
| LMAN2 protein network | https://string-db.org/network/9606.ENSP00000303366 | Vesicular integral-membrane protein VIP36; Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high-mannose type glycans and may al [...] |
| HIST1H2AE protein network | https://string-db.org/network/9606.ENSP00000303373 | Histone cluster 1 H2A family member e; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| HSPB3 protein network | https://string-db.org/network/9606.ENSP00000303394 | Heat shock protein beta-3; Inhibitor of actin polymerization; Small heat shock proteins |
| MTBP protein network | https://string-db.org/network/9606.ENSP00000303398 | Mdm2-binding protein; Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed ce [...] |
| FNTA protein network | https://string-db.org/network/9606.ENSP00000303423 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfe [...] |
| PTGDR protein network | https://string-db.org/network/9606.ENSP00000303424 | Prostaglandin D2 receptor; Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of i [...] |
| PDS5A protein network | https://string-db.org/network/9606.ENSP00000303427 | Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chro [...] |
| USP38 protein network | https://string-db.org/network/9606.ENSP00000303434 | Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards 'Lys-63'-linked ubiquitin chains; Belongs to the peptidase C19 family |
| TSNARE1 protein network | https://string-db.org/network/9606.ENSP00000303437 | t-SNARE domain containing 1 |
| TRH protein network | https://string-db.org/network/9606.ENSP00000303452 | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nerv [...] |
| ZCCHC4 protein network | https://string-db.org/network/9606.ENSP00000303468 | Zinc finger CCHC domain-containing protein 4; May be a methyltransferase; Seven-beta-strand methyltransferase motif containing |
| OR52A5 protein network | https://string-db.org/network/9606.ENSP00000303469 | Olfactory receptor 52A5; Odorant receptor; Olfactory receptors, family 52 |
| REEP4 protein network | https://string-db.org/network/9606.ENSP00000303482 | Receptor expression-enhancing protein 4; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from ch [...] |
| C5orf34 protein network | https://string-db.org/network/9606.ENSP00000303490 | Uncharacterized protein C5orf34; Chromosome 5 open reading frame 34 |
| BCR protein network | https://string-db.org/network/9606.ENSP00000303507 | Breakpoint cluster region protein; GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. Displays serine/threonine kinase [...] |
| FRMD3 protein network | https://string-db.org/network/9606.ENSP00000303508 | FERM domain-containing protein 3; Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer; FERM domain containing |
| PEX6 protein network | https://string-db.org/network/9606.ENSP00000303511 | Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase [...] |
| TACR1 protein network | https://string-db.org/network/9606.ENSP00000303522 | Substance-P receptor; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger syste [...] |
| CBR4 protein network | https://string-db.org/network/9606.ENSP00000303525 | Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid bi [...] |
| DEFB4A protein network | https://string-db.org/network/9606.ENSP00000303532 | Defensin, beta 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse [...] |
| ZNF138 protein network | https://string-db.org/network/9606.ENSP00000303533 | Zinc finger protein 138; May be involved in transcriptional regulation as a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SCN1A protein network | https://string-db.org/network/9606.ENSP00000303540 | Sodium channel protein type 1 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| GPR82 protein network | https://string-db.org/network/9606.ENSP00000303549 | Probable G-protein coupled receptor 82; Orphan receptor; G protein-coupled receptors, Class A orphans |
| CYTL1 protein network | https://string-db.org/network/9606.ENSP00000303550 | Cytokine-like protein 1; Cytokine like 1 |
| ANKMY2 protein network | https://string-db.org/network/9606.ENSP00000303570 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia; Ankyrin repeat domain containing |
| NUDT9 protein network | https://string-db.org/network/9606.ENSP00000303575 | ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'- phosphate; Nudix hydrolase family |
| NKIRAS2 protein network | https://string-db.org/network/9606.ENSP00000303580 | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (N [...] |
| N6AMT1 protein network | https://string-db.org/network/9606.ENSP00000303584 | HemK methyltransferase family member 2; Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be comple [...] |
| LRP8 protein network | https://string-db.org/network/9606.ENSP00000303634 | Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Ree [...] |
| NTSR2 protein network | https://string-db.org/network/9606.ENSP00000303686 | Neurotensin receptor type 2; Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| ZNF57 protein network | https://string-db.org/network/9606.ENSP00000303696 | Zinc finger protein 57; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CDC25A protein network | https://string-db.org/network/9606.ENSP00000303706 | M-phase inducer phosphatase 1; Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity [...] |
| UBE2E1 protein network | https://string-db.org/network/9606.ENSP00000303709 | Ubiquitin-conjugating enzyme E2 E1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Me [...] |
| PPID protein network | https://string-db.org/network/9606.ENSP00000303754 | Peptidyl-prolyl cis-trans isomerase D; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a [...] |
| LUZP1 protein network | https://string-db.org/network/9606.ENSP00000303758 | Leucine zipper protein 1 |
| HTRA3 protein network | https://string-db.org/network/9606.ENSP00000303766 | Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits si [...] |
| AKNA protein network | https://string-db.org/network/9606.ENSP00000303769 | AT-hook-containing transcription factor; Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes [...] |
| PROKR1 protein network | https://string-db.org/network/9606.ENSP00000303775 | Prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinosit [...] |
| TEX13B protein network | https://string-db.org/network/9606.ENSP00000303777 | Testis-expressed protein 13B; Testis expressed 13B; Belongs to the TEX13 family |
| OR7G2 protein network | https://string-db.org/network/9606.ENSP00000303822 | Olfactory receptor 7G2; Odorant receptor; Olfactory receptors, family 7 |
| INSR protein network | https://string-db.org/network/9606.ENSP00000303830 | Insulin receptor; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin r [...] |
| OR5A2 protein network | https://string-db.org/network/9606.ENSP00000303834 | Olfactory receptor 5A2; Odorant receptor; Olfactory receptors, family 5 |
| OR10A2 protein network | https://string-db.org/network/9606.ENSP00000303862 | Olfactory receptor 10A2; Odorant receptor; Olfactory receptors, family 10 |
| OR8I2 protein network | https://string-db.org/network/9606.ENSP00000303864 | Olfactory receptor 8I2; Odorant receptor; Olfactory receptors, family 8 |
| DCLK2 protein network | https://string-db.org/network/9606.ENSP00000303887 | Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-reg [...] |
| TWF2 protein network | https://string-db.org/network/9606.ENSP00000303908 | Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also [...] |
| ABR protein network | https://string-db.org/network/9606.ENSP00000303909 | Active breakpoint cluster region-related protein; GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them; C2 domain containin [...] |
| ZNF561 protein network | https://string-db.org/network/9606.ENSP00000303915 | Zinc finger protein 561; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MZB1 protein network | https://string-db.org/network/9606.ENSP00000303920 | Marginal zone B- and B1-cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular [...] |
| KIAA0232 protein network | https://string-db.org/network/9606.ENSP00000303928 | Uncharacterized protein KIAA0232; KIAA0232 |
| CTLA4 protein network | https://string-db.org/network/9606.ENSP00000303939 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is consider [...] |
| GP9 protein network | https://string-db.org/network/9606.ENSP00000303942 | Platelet glycoprotein IX; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces [...] |
| ABCC8 protein network | https://string-db.org/network/9606.ENSP00000303960 | ATP-binding cassette sub-family C member 8; Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release; ATP binding cassette sub [...] |
| CTRB2 protein network | https://string-db.org/network/9606.ENSP00000303963 | Chymotrypsinogen B2; Belongs to the peptidase S1 family |
| TMEM223 protein network | https://string-db.org/network/9606.ENSP00000303987 | Transmembrane protein 223 |
| TMEM43 protein network | https://string-db.org/network/9606.ENSP00000303992 | Transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the [...] |
| GTPBP2 protein network | https://string-db.org/network/9606.ENSP00000303997 | GTP binding protein 2; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily |
| FOXA3 protein network | https://string-db.org/network/9606.ENSP00000304004 | Hepatocyte nuclear factor 3-gamma; Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core [...] |
| STARD5 protein network | https://string-db.org/network/9606.ENSP00000304032 | StAR-related lipid transfer protein 5; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfe [...] |
| RNF139 protein network | https://string-db.org/network/9606.ENSP00000304051 | E3 ubiquitin-protein ligase RNF139; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I u [...] |
| OR8J1 protein network | https://string-db.org/network/9606.ENSP00000304060 | Olfactory receptor 8J1; Odorant receptor; Olfactory receptors, family 8 |
| C2orf27B protein network | https://string-db.org/network/9606.ENSP00000304065 | Chromosome 2 open reading frame 27B |
| C7orf33 protein network | https://string-db.org/network/9606.ENSP00000304071 | Uncharacterized protein C7orf33; Chromosome 7 open reading frame 33 |
| OR4K15 protein network | https://string-db.org/network/9606.ENSP00000304077 | Olfactory receptor 4K15; Odorant receptor; Olfactory receptors, family 4 |
| FAM83B protein network | https://string-db.org/network/9606.ENSP00000304078 | Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR s [...] |
| COPS6 protein network | https://string-db.org/network/9606.ENSP00000304102 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| FAM171B protein network | https://string-db.org/network/9606.ENSP00000304108 | Protein FAM171B; Family with sequence similarity 171 member B; Belongs to the FAM171 family |
| KCNG3 protein network | https://string-db.org/network/9606.ENSP00000304127 | Potassium voltage-gated channel subfamily G member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; this pr [...] |
| SCG2 protein network | https://string-db.org/network/9606.ENSP00000304133 | Secretogranin-2; Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides; Granins |
| RBMXL2 protein network | https://string-db.org/network/9606.ENSP00000304139 | RNA binding motif protein, X-linked like 2 |
| MYEOV2 protein network | https://string-db.org/network/9606.ENSP00000304147 | Myeloma overexpressed 2 |
| PITX2 protein network | https://string-db.org/network/9606.ENSP00000304169 | Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. [...] |
| OR8U1 protein network | https://string-db.org/network/9606.ENSP00000304188 | Olfactory receptor 8U1; Odorant receptor; Olfactory receptors, family 8 |
| PCNX protein network | https://string-db.org/network/9606.ENSP00000304192 | Pecanex-like protein 1; Pecanex homolog (Drosophila); Belongs to the pecanex family |
| HIPK3 protein network | https://string-db.org/network/9606.ENSP00000304226 | Homeodomain-interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to [...] |
| HINT1 protein network | https://string-db.org/network/9606.ENSP00000304229 | Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monopho [...] |
| PCDHA10 protein network | https://string-db.org/network/9606.ENSP00000304234 | Protocadherin alpha-10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| OR1L6 protein network | https://string-db.org/network/9606.ENSP00000304235 | Olfactory receptor 1L6; Odorant receptor; Olfactory receptors, family 1 |
| CD14 protein network | https://string-db.org/network/9606.ENSP00000304236 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby me [...] |
| CDK5R2 protein network | https://string-db.org/network/9606.ENSP00000304250 | Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII |
| ZNF33A protein network | https://string-db.org/network/9606.ENSP00000304268 | Zinc finger protein 33A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TM4SF1 protein network | https://string-db.org/network/9606.ENSP00000304277 | Transmembrane 4 L six family member 1 |
| RAC3 protein network | https://string-db.org/network/9606.ENSP00000304283 | Ras-related C3 botulinum toxin substrate 3; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of ef [...] |
| FOXI1 protein network | https://string-db.org/network/9606.ENSP00000304286 | Forkhead box protein I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH [...] |
| CHRNB1 protein network | https://string-db.org/network/9606.ENSP00000304290 | Acetylcholine receptor subunit beta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting chan [...] |
| ANKRD27 protein network | https://string-db.org/network/9606.ENSP00000304292 | Ankyrin repeat domain-containing protein 27; May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane [...] |
| COPRS protein network | https://string-db.org/network/9606.ENSP00000304327 | Coordinator of PRMT5 and differentiation stimulator; Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation [...] |
| GSX1 protein network | https://string-db.org/network/9606.ENSP00000304331 | GS homeobox 1; Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary developmen [...] |
| PYDC1 protein network | https://string-db.org/network/9606.ENSP00000304336 | Pyrin domain-containing protein 1; Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses k [...] |
| POP7 protein network | https://string-db.org/network/9606.ENSP00000304353 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cle [...] |
| CCDC126 protein network | https://string-db.org/network/9606.ENSP00000304355 | Coiled-coil domain containing 126 |
| SMYD4 protein network | https://string-db.org/network/9606.ENSP00000304360 | SET and MYND domain containing 4; Belongs to the class V-like SAM-binding methyltransferase superfamily |
| C1GALT1C1 protein network | https://string-db.org/network/9606.ENSP00000304364 | C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O- glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glyco [...] |
| RAB24 protein network | https://string-db.org/network/9606.ENSP00000304376 | Ras-related protein Rab-24; May be involved in autophagy-related processes; Belongs to the small GTPase superfamily. Rab family |
| COL3A1 protein network | https://string-db.org/network/9606.ENSP00000304408 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in [...] |
| C2orf68 protein network | https://string-db.org/network/9606.ENSP00000304410 | UPF0561 protein C2orf68; Chromosome 2 open reading frame 68 |
| OR2B2 protein network | https://string-db.org/network/9606.ENSP00000304419 | Olfactory receptor 2B2; Odorant receptor; Olfactory receptors, family 2 |
| KREMEN2 protein network | https://string-db.org/network/9606.ENSP00000304422 | Kremen protein 2; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. Plays a role in limb de [...] |
| SNX7 protein network | https://string-db.org/network/9606.ENSP00000304429 | Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family |
| KNDC1 protein network | https://string-db.org/network/9606.ENSP00000304437 | Protein very KIND; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (By similar [...] |
| HAS3 protein network | https://string-db.org/network/9606.ENSP00000304440 | Hyaluronan synthase 3; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...] |
| THOP1 protein network | https://string-db.org/network/9606.ENSP00000304467 | Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor prote [...] |
| ADORA2B protein network | https://string-db.org/network/9606.ENSP00000304501 | Adenosine receptor A2b; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase |
| SIX2 protein network | https://string-db.org/network/9606.ENSP00000304502 | Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenc [...] |
| MPLKIP protein network | https://string-db.org/network/9606.ENSP00000304553 | M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis |
| ANKS3 protein network | https://string-db.org/network/9606.ENSP00000304586 | Ankyrin repeat and sterile alpha motif domain containing 3 |
| FASN protein network | https://string-db.org/network/9606.ENSP00000304592 | Fatty acid synthase; Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and a [...] |
| ZNHIT1 protein network | https://string-db.org/network/9606.ENSP00000304593 | Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction. Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 withou [...] |
| MAGI3 protein network | https://string-db.org/network/9606.ENSP00000304604 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Co [...] |
| FAM134B protein network | https://string-db.org/network/9606.ENSP00000304642 | Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and E [...] |
| CALML6 protein network | https://string-db.org/network/9606.ENSP00000304643 | Calmodulin-like protein 6; EF-hand domain containing; Belongs to the calmodulin family. Calglandulin subfamily |
| CTNNA1 protein network | https://string-db.org/network/9606.ENSP00000304669 | Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and w [...] |
| RNFT1 protein network | https://string-db.org/network/9606.ENSP00000304670 | E3 ubiquitin-protein ligase RNFT1; E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate [...] |
| ATOH8 protein network | https://string-db.org/network/9606.ENSP00000304676 | Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH [...] |
| THAP11 protein network | https://string-db.org/network/9606.ENSP00000304689 | THAP domain-containing protein 11; Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor th [...] |
| UBB protein network | https://string-db.org/network/9606.ENSP00000304697 | Polyubiquitin-B; Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as [...] |
| MSANTD4 protein network | https://string-db.org/network/9606.ENSP00000304713 | Myb/SANT-like DNA-binding domain-containing protein 4; Myb/SANT DNA binding domain containing 4 with coiled-coils |
| SPACA5B protein network | https://string-db.org/network/9606.ENSP00000304762 | Sperm acrosome associated 5B; Lysozymes, c-type |
| P2RY1 protein network | https://string-db.org/network/9606.ENSP00000304767 | P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholi [...] |
| ZNF467 protein network | https://string-db.org/network/9606.ENSP00000304769 | Zinc finger protein 467; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of s [...] |
| CES3 protein network | https://string-db.org/network/9606.ENSP00000304782 | Carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-pipe [...] |
| SLC26A5 protein network | https://string-db.org/network/9606.ENSP00000304783 | Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage- to [...] |
| DTYMK protein network | https://string-db.org/network/9606.ENSP00000304802 | Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family |
| OR6Y1 protein network | https://string-db.org/network/9606.ENSP00000304807 | Olfactory receptor 6Y1; Odorant receptor; Olfactory receptors, family 6 |
| UGT2B7 protein network | https://string-db.org/network/9606.ENSP00000304811 | UDP-glucuronosyltransferase 2B7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosylt [...] |
| CSN3 protein network | https://string-db.org/network/9606.ENSP00000304822 | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family |
| UGT1A8 protein network | https://string-db.org/network/9606.ENSP00000304845 | UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates [...] |
| OR2AT4 protein network | https://string-db.org/network/9606.ENSP00000304846 | Olfactory receptor 2AT4; Odorant receptor; Olfactory receptors, family 2 |
| NUDCD2 protein network | https://string-db.org/network/9606.ENSP00000304854 | NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone; NudC family |
| ATP6V1E2 protein network | https://string-db.org/network/9606.ENSP00000304891 | V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intrace [...] |
| IRS1 protein network | https://string-db.org/network/9606.ENSP00000304895 | Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins contain [...] |
| CD2BP2 protein network | https://string-db.org/network/9606.ENSP00000304903 | CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly; Protein phosphatase 1 regulatory subun [...] |
| TXNDC2 protein network | https://string-db.org/network/9606.ENSP00000304908 | Thioredoxin domain-containing protein 2; Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulf [...] |
| IL13 protein network | https://string-db.org/network/9606.ENSP00000304915 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. [...] |
| LRRC28 protein network | https://string-db.org/network/9606.ENSP00000304923 | Leucine-rich repeat-containing protein 28; Leucine rich repeat containing 28 |
| C8orf22 protein network | https://string-db.org/network/9606.ENSP00000304926 | Pancreatic progenitor cell differentiation and proliferation factor-like protein; Chromosome 8 open reading frame 22 |
| SOSTDC1 protein network | https://string-db.org/network/9606.ENSP00000304930 | Sclerostin domain-containing protein 1; May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits T [...] |
| TCTN2 protein network | https://string-db.org/network/9606.ENSP00000304941 | Tectonic-2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between t [...] |
| ROBO4 protein network | https://string-db.org/network/9606.ENSP00000304945 | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migr [...] |
| MN1 protein network | https://string-db.org/network/9606.ENSP00000304956 | Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate [...] |
| BFSP2 protein network | https://string-db.org/network/9606.ENSP00000304987 | Phakinin; Involved in stabilization of lens fiber cell cytoskeleton; Belongs to the intermediate filament family |
| PSG8 protein network | https://string-db.org/network/9606.ENSP00000305005 | Pregnancy specific beta-1-glycoprotein 8 |
| OR4K14 protein network | https://string-db.org/network/9606.ENSP00000305011 | Olfactory receptor 4K14; Odorant receptor; Olfactory receptors, family 4 |
| OR2K2 protein network | https://string-db.org/network/9606.ENSP00000305055 | Olfactory receptor 2K2; Odorant receptor; Olfactory receptors, family 2 |
| TMEM192 protein network | https://string-db.org/network/9606.ENSP00000305069 | Transmembrane protein 192 |
| RFXANK protein network | https://string-db.org/network/9606.ENSP00000305071 | DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. R [...] |
| ZNF439 protein network | https://string-db.org/network/9606.ENSP00000305077 | Zinc finger protein 439; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GIMAP8 protein network | https://string-db.org/network/9606.ENSP00000305107 | GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections; GTPases, IMAP |
| SOCS5 protein network | https://string-db.org/network/9606.ENSP00000305133 | Suppressor of cytokine signaling 5; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of [...] |
| FAM195A protein network | https://string-db.org/network/9606.ENSP00000305138 | MAPK regulated corepressor interacting protein 2; Family with sequence similarity 195, member A |
| PWWP2A protein network | https://string-db.org/network/9606.ENSP00000305151 | PWWP domain-containing protein 2A; H2A.Z-specific chromatin binding protein which may play an important role in the neural crest stem cell migration and differentiation during early development. [...] |
| TRIM56 protein network | https://string-db.org/network/9606.ENSP00000305161 | E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets [...] |
| HS1BP3 protein network | https://string-db.org/network/9606.ENSP00000305193 | HCLS1-binding protein 3; May be a modulator of IL-2 signaling |
| CKAP2L protein network | https://string-db.org/network/9606.ENSP00000305204 | Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells |
| OR1A1 protein network | https://string-db.org/network/9606.ENSP00000305207 | Olfactory receptor 1A1; Odorant receptor; Olfactory receptors, family 1 |
| UGT2B4 protein network | https://string-db.org/network/9606.ENSP00000305221 | UDP-glucuronosyltransferase 2B4; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on [...] |
| SRP9 protein network | https://string-db.org/network/9606.ENSP00000305230 | Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with [...] |
| IRX1 protein network | https://string-db.org/network/9606.ENSP00000305244 | Iroquois-class homeodomain protein IRX-1; TALE class homeoboxes and pseudogenes |
| STX8 protein network | https://string-db.org/network/9606.ENSP00000305255 | Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER; Belongs to the syntaxin famil [...] |
| GNB2 protein network | https://string-db.org/network/9606.ENSP00000305260 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...] |
| KRT28 protein network | https://string-db.org/network/9606.ENSP00000305263 | Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs) |
| NLGN2 protein network | https://string-db.org/network/9606.ENSP00000305288 | Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other [...] |
| SLC6A19 protein network | https://string-db.org/network/9606.ENSP00000305302 | Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This upta [...] |
| FSTL5 protein network | https://string-db.org/network/9606.ENSP00000305334 | Follistatin-related protein 5; EF-hand domain containing |
| SOX14 protein network | https://string-db.org/network/9606.ENSP00000305343 | Transcription factor SOX-14; Acts as a negative regulator of transcription; SRY-boxes |
| PRKCB protein network | https://string-db.org/network/9606.ENSP00000305355 | Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B- [...] |
| ADRB2 protein network | https://string-db.org/network/9606.ENSP00000305372 | Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epi [...] |
| ZNF440 protein network | https://string-db.org/network/9606.ENSP00000305373 | Zinc finger protein 440; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR5T3 protein network | https://string-db.org/network/9606.ENSP00000305403 | Olfactory receptor 5T3; Odorant receptor; Olfactory receptors, family 5 |
| S1PR1 protein network | https://string-db.org/network/9606.ENSP00000305416 | Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G prot [...] |
| CEBPB protein network | https://string-db.org/network/9606.ENSP00000305422 | CCAAT/enhancer-binding protein beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis [...] |
| OR1F1 protein network | https://string-db.org/network/9606.ENSP00000305424 | Olfactory receptor 1F1; Odorant receptor; Olfactory receptors, family 1 |
| TUB protein network | https://string-db.org/network/9606.ENSP00000305426 | Tubby protein homolog; Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitr [...] |
| COG7 protein network | https://string-db.org/network/9606.ENSP00000305442 | Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function; Components of oligomeric golgi complex |
| CNNM3 protein network | https://string-db.org/network/9606.ENSP00000305449 | Metal transporter CNNM3; Probable metal transporter; Belongs to the ACDP family |
| COG8 protein network | https://string-db.org/network/9606.ENSP00000305459 | Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function; Components of oligomeric golgi complex |
| PDILT protein network | https://string-db.org/network/9606.ENSP00000305465 | Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis; Belongs to the protein disulfide isomerase family |
| OR1S2 protein network | https://string-db.org/network/9606.ENSP00000305469 | Olfactory receptor 1S2; Odorant receptor; Olfactory receptors, family 1 |
| FEN1 protein network | https://string-db.org/network/9606.ENSP00000305480 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhang [...] |
| SPATA5L1 protein network | https://string-db.org/network/9606.ENSP00000305494 | Spermatogenesis-associated protein 5-like protein 1; Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. AFG2 subfamily |
| SIRPG protein network | https://string-db.org/network/9606.ENSP00000305529 | Signal-regulatory protein gamma; Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells [...] |
| THAP9 protein network | https://string-db.org/network/9606.ENSP00000305533 | DNA transposase THAP9; Active transposase that specifically recognizes the bipartite 5'-TXXGGGX(A/T)-3' consensus motif and mediates transposition; THAP domain containing |
| PCBP1 protein network | https://string-db.org/network/9606.ENSP00000305556 | Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. In case of infection by poliovirus, plays a role in initiation of viral RNA replica [...] |
| B3GNT2 protein network | https://string-db.org/network/9606.ENSP00000305595 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elon [...] |
| FAM71B protein network | https://string-db.org/network/9606.ENSP00000305596 | Protein FAM71B; May be involved in RNA biogenesis |
| FUT3 protein network | https://string-db.org/network/9606.ENSP00000305603 | Galactoside 3(4)-L-fucosyltransferase; May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. [...] |
| CPLX1 protein network | https://string-db.org/network/9606.ENSP00000305613 | Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigza [...] |
| NXNL1 protein network | https://string-db.org/network/9606.ENSP00000305631 | Nucleoredoxin-like protein 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods; Nucleoredoxin family |
| HOMER2 protein network | https://string-db.org/network/9606.ENSP00000305632 | Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...] |
| OR6F1 protein network | https://string-db.org/network/9606.ENSP00000305640 | Olfactory receptor 6F1; Odorant receptor; Olfactory receptors, family 6 |
| VAMP5 protein network | https://string-db.org/network/9606.ENSP00000305647 | Vesicle-associated membrane protein 5; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking; Belongs to the synaptobrevin fa [...] |
| CXCL10 protein network | https://string-db.org/network/9606.ENSP00000305651 | C-X-C motif chemokine 10; Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3; Belongs to the intercrine alpha (chemokine CxC) family |
| LETM1 protein network | https://string-db.org/network/9606.ENSP00000305653 | Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondr [...] |
| TVP23B protein network | https://string-db.org/network/9606.ENSP00000305654 | Trans-golgi network vesicle protein 23 homolog B; Belongs to the TVP23 family |
| TRABD protein network | https://string-db.org/network/9606.ENSP00000305664 | TraB domain-containing protein; TraB domain containing |
| SDPR protein network | https://string-db.org/network/9606.ENSP00000305675 | Caveolae-associated protein 2; Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola [...] |
| MRPL39 protein network | https://string-db.org/network/9606.ENSP00000305682 | Mitochondrial ribosomal protein L39; Belongs to the mitochondrion-specific ribosomal protein mL39 family |
| GAA protein network | https://string-db.org/network/9606.ENSP00000305692 | Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans |
| RBFA protein network | https://string-db.org/network/9606.ENSP00000305696 | Putative ribosome-binding factor A, mitochondrial; Ribosome binding factor A |
| HOOK3 protein network | https://string-db.org/network/9606.ENSP00000305699 | Protein Hook homolog 3; Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). [...] |
| KCTD19 protein network | https://string-db.org/network/9606.ENSP00000305702 | BTB/POZ domain-containing protein KCTD19; Potassium channel tetramerization domain containing 19 |
| BMP1 protein network | https://string-db.org/network/9606.ENSP00000305714 | Bone morphogenetic protein 1; Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early develo [...] |
| IBTK protein network | https://string-db.org/network/9606.ENSP00000305721 | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interferenc [...] |
| CHST11 protein network | https://string-db.org/network/9606.ENSP00000305725 | Carbohydrate sulfotransferase 11; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant pro [...] |
| CST1 protein network | https://string-db.org/network/9606.ENSP00000305731 | Cystatin-SN; Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence [...] |
| LRTOMT protein network | https://string-db.org/network/9606.ENSP00000305742 | Transmembrane O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory funct [...] |
| MRGPRX1 protein network | https://string-db.org/network/9606.ENSP00000305766 | Mas-related G-protein coupled receptor member X1; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...] |
| CSNK1G1 protein network | https://string-db.org/network/9606.ENSP00000305777 | Casein kinase I isoform gamma-1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...] |
| SF3B3 protein network | https://string-db.org/network/9606.ENSP00000305790 | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| STX18 protein network | https://string-db.org/network/9606.ENSP00000305810 | Syntaxin-18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; Syntaxins |
| GPRIN1 protein network | https://string-db.org/network/9606.ENSP00000305839 | G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth |
| SPACA5 protein network | https://string-db.org/network/9606.ENSP00000305847 | Sperm acrosome associated 5; Belongs to the glycosyl hydrolase 22 family |
| TM4SF4 protein network | https://string-db.org/network/9606.ENSP00000305852 | Transmembrane 4 L6 family member 4; Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation |
| C20orf196 protein network | https://string-db.org/network/9606.ENSP00000305875 | Uncharacterized protein C20orf196; Chromosome 20 open reading frame 196 |
| NMUR1 protein network | https://string-db.org/network/9606.ENSP00000305877 | Neuromedin-U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides |
| TMEM208 protein network | https://string-db.org/network/9606.ENSP00000305892 | Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy |
| SUV420H1 protein network | https://string-db.org/network/9606.ENSP00000305899 | Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic tra [...] |
| UTF1 protein network | https://string-db.org/network/9606.ENSP00000305906 | Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2 |
| BRD3 protein network | https://string-db.org/network/9606.ENSP00000305918 | Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and in [...] |
| HTRA4 protein network | https://string-db.org/network/9606.ENSP00000305919 | Serine protease HTRA4; Serine protease; PDZ domain containing |
| PPP4R4 protein network | https://string-db.org/network/9606.ENSP00000305924 | Serine/threonine-protein phosphatase 4 regulatory subunit 4; Putative regulatory subunit of serine/threonine-protein phosphatase 4; Armadillo-like helical domain containing |
| OTUD7A protein network | https://string-db.org/network/9606.ENSP00000305926 | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains; Belongs to the peptidase C64 family |
| USH2A protein network | https://string-db.org/network/9606.ENSP00000305941 | Usherin; Involved in hearing and vision; Fibronectin type III domain containing |
| OR4D5 protein network | https://string-db.org/network/9606.ENSP00000305970 | Olfactory receptor 4D5; Odorant receptor; Olfactory receptors, family 4 |
| SLCO1A2 protein network | https://string-db.org/network/9606.ENSP00000305974 | Solute carrier organic anion transporter family member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjug [...] |
| KRTAP1-1 protein network | https://string-db.org/network/9606.ENSP00000305975 | Keratin-associated protein 1-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| SIK2 protein network | https://string-db.org/network/9606.ENSP00000305976 | Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activi [...] |
| ALCAM protein network | https://string-db.org/network/9606.ENSP00000305988 | CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proli [...] |
| PGK2 protein network | https://string-db.org/network/9606.ENSP00000305995 | Phosphoglycerate kinase 2; Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis (By similarity); Belongs to the phosphoglycerate kinase family |
| ATP5I protein network | https://string-db.org/network/9606.ENSP00000306003 | ATP synthase subunit e, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane whic [...] |
| ARF4 protein network | https://string-db.org/network/9606.ENSP00000306010 | ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may m [...] |
| SYNPO2 protein network | https://string-db.org/network/9606.ENSP00000306015 | Synaptopodin-2; Isoform 4: Can induce long, well-organized actin bundles frequently orientated in parallel along the long axis of the cell showing characteristics of contractile ventral stress fi [...] |
| NUDT6 protein network | https://string-db.org/network/9606.ENSP00000306070 | Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation; Belongs to the Nudix hydrolase family |
| RNMTL1 protein network | https://string-db.org/network/9606.ENSP00000306080 | rRNA methyltransferase 3, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methylguanosine at position 1370 (Gm1370) in the 16S [...] |
| OR10H2 protein network | https://string-db.org/network/9606.ENSP00000306095 | Olfactory receptor 10H2; Odorant receptor; Olfactory receptors, family 10 |
| FGB protein network | https://string-db.org/network/9606.ENSP00000306099 | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fi [...] |
| PAM protein network | https://string-db.org/network/9606.ENSP00000306100 | Peptidyl-glycine alpha-amidating monooxygenase; Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptid [...] |
| CEP89 protein network | https://string-db.org/network/9606.ENSP00000306105 | Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity |
| JAGN1 protein network | https://string-db.org/network/9606.ENSP00000306106 | Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; [...] |
| DDX19A protein network | https://string-db.org/network/9606.ENSP00000306117 | ATP-dependent RNA helicase DDX19A; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein par [...] |
| RPAP1 protein network | https://string-db.org/network/9606.ENSP00000306123 | RNA polymerase II-associated protein 1; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to r [...] |
| PRKCE protein network | https://string-db.org/network/9606.ENSP00000306124 | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellu [...] |
| DRD5 protein network | https://string-db.org/network/9606.ENSP00000306129 | D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family |
| GRM5 protein network | https://string-db.org/network/9606.ENSP00000306138 | Metabotropic glutamate receptor 5; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| IL7R protein network | https://string-db.org/network/9606.ENSP00000306157 | Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP); Belongs to the type I cytokine receptor family. Type 4 subfamily |
| ANKRD2 protein network | https://string-db.org/network/9606.ENSP00000306163 | Ankyrin repeat domain-containing protein 2; Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate [...] |
| ANTXR2 protein network | https://string-db.org/network/9606.ENSP00000306185 | Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix |
| SLAMF1 protein network | https://string-db.org/network/9606.ENSP00000306190 | Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interact [...] |
| MMGT1 protein network | https://string-db.org/network/9606.ENSP00000306220 | Membrane magnesium transporter 1; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family |
| FOS protein network | https://string-db.org/network/9606.ENSP00000306245 | Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each [...] |
| ITPR1 protein network | https://string-db.org/network/9606.ENSP00000306253 | Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved i [...] |
| KRT78 protein network | https://string-db.org/network/9606.ENSP00000306261 | Keratin, type II cytoskeletal 78; Keratins, type II |
| KCNK3 protein network | https://string-db.org/network/9606.ENSP00000306275 | Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of [...] |
| C14orf142 protein network | https://string-db.org/network/9606.ENSP00000306320 | EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...] |
| PWWP2B protein network | https://string-db.org/network/9606.ENSP00000306324 | PWWP domain containing 2B |
| SLC25A33 protein network | https://string-db.org/network/9606.ENSP00000306328 | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deox [...] |
| YWHAG protein network | https://string-db.org/network/9606.ENSP00000306330 | 14-3-3 protein gamma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognit [...] |
| RFX2 protein network | https://string-db.org/network/9606.ENSP00000306335 | DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such a [...] |
| TMEM135 protein network | https://string-db.org/network/9606.ENSP00000306344 | Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes D [...] |
| FGA protein network | https://string-db.org/network/9606.ENSP00000306361 | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fi [...] |
| TBCA protein network | https://string-db.org/network/9606.ENSP00000306362 | Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway |
| ZNF3 protein network | https://string-db.org/network/9606.ENSP00000306372 | Zinc finger protein 3; Involved in cell differentiation and/or proliferation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PRSS27 protein network | https://string-db.org/network/9606.ENSP00000306390 | Serine protease 27 |
| RNF187 protein network | https://string-db.org/network/9606.ENSP00000306396 | E3 ubiquitin-protein ligase RNF187; E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independe [...] |
| UQCRFS1 protein network | https://string-db.org/network/9606.ENSP00000306397 | Cytochrome b-c1 complex subunit Rieske, mitochondrial; Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (comple [...] |
| ARMC4 protein network | https://string-db.org/network/9606.ENSP00000306410 | Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly; Armadillo repeat containing |
| CHCHD7 protein network | https://string-db.org/network/9606.ENSP00000306425 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins; Belongs to the CHCHD7 family |
| GPR37 protein network | https://string-db.org/network/9606.ENSP00000306449 | Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; Belongs to the G- [...] |
| B4GALT6 protein network | https://string-db.org/network/9606.ENSP00000306459 | Beta-1,4-galactosyltransferase 6; Required for the biosynthesis of glycosphingolipids; Beta 4-glycosyltransferases |
| SPRR1B protein network | https://string-db.org/network/9606.ENSP00000306461 | Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transg [...] |
| SHCBP1 protein network | https://string-db.org/network/9606.ENSP00000306473 | SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstre [...] |
| CHRM1 protein network | https://string-db.org/network/9606.ENSP00000306490 | Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...] |
| RAB33B protein network | https://string-db.org/network/9606.ENSP00000306496 | Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagoso [...] |
| KCNJ4 protein network | https://string-db.org/network/9606.ENSP00000306497 | Inward rectifier potassium channel 4; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dep [...] |
| CXCL8 protein network | https://string-db.org/network/9606.ENSP00000306512 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell ty [...] |
| CAMTA1 protein network | https://string-db.org/network/9606.ENSP00000306522 | Calmodulin-binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor; Belongs to the CAMTA family |
| INSM2 protein network | https://string-db.org/network/9606.ENSP00000306523 | Insulinoma-associated protein 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons; SNAG transcriptional repressors |
| DESI2 protein network | https://string-db.org/network/9606.ENSP00000306528 | Desumoylating isopeptidase 2; Protease which may deconjugate SUMO from some substrate proteins; Desumoylating isopeptidases |
| MRPL13 protein network | https://string-db.org/network/9606.ENSP00000306548 | Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family |
| OGG1 protein network | https://string-db.org/network/9606.ENSP00000306561 | N-glycosylase/DNA lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. [...] |
| TMEM42 protein network | https://string-db.org/network/9606.ENSP00000306564 | Transmembrane protein 42 |
| ISG20 protein network | https://string-db.org/network/9606.ENSP00000306565 | Interferon-stimulated gene 20 kDa protein; Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single- stranded DNA. Exhibits antivir [...] |
| ADH1B protein network | https://string-db.org/network/9606.ENSP00000306606 | Alcohol dehydrogenase 1B, beta polypeptide; Belongs to the zinc-containing alcohol dehydrogenase family |
| OR1L8 protein network | https://string-db.org/network/9606.ENSP00000306607 | Olfactory receptor 1L8; Odorant receptor; Olfactory receptors, family 1 |
| PPIH protein network | https://string-db.org/network/9606.ENSP00000306614 | Peptidyl-prolyl cis-trans isomerase H; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-m [...] |
| ASPSCR1 protein network | https://string-db.org/network/9606.ENSP00000306625 | Tether containing UBX domain for GLUT4; Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at [...] |
| SLC9C1 protein network | https://string-db.org/network/9606.ENSP00000306627 | Sodium/hydrogen exchanger 10; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hy [...] |
| RGPD8 protein network | https://string-db.org/network/9606.ENSP00000306637 | RANBP2-like and GRIP domain-containing protein 8; Tetratricopeptide repeat domain containing |
| OR4C11 protein network | https://string-db.org/network/9606.ENSP00000306651 | Olfactory receptor 4C11; Odorant receptor; Olfactory receptors, family 4 |
| OR5B12 protein network | https://string-db.org/network/9606.ENSP00000306657 | Olfactory receptor 5B12; Odorant receptor; Olfactory receptors, family 5 |
| ADRA1B protein network | https://string-db.org/network/9606.ENSP00000306662 | Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect i [...] |
| NUDT16L1 protein network | https://string-db.org/network/9606.ENSP00000306670 | Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem T [...] |
| ANKK1 protein network | https://string-db.org/network/9606.ENSP00000306678 | Ankyrin repeat and kinase domain containing 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family |
| PPM1D protein network | https://string-db.org/network/9606.ENSP00000306682 | Protein phosphatase 1D; Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to [...] |
| OR2M4 protein network | https://string-db.org/network/9606.ENSP00000306688 | Olfactory receptor 2M4; Odorant receptor; Olfactory receptors, family 2 |
| BOLA2B protein network | https://string-db.org/network/9606.ENSP00000306752 | bolA family member 2B; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monot [...] |
| NEUROD2 protein network | https://string-db.org/network/9606.ENSP00000306754 | Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. C [...] |
| ZNF584 protein network | https://string-db.org/network/9606.ENSP00000306756 | Zinc finger protein 584; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LRRC45 protein network | https://string-db.org/network/9606.ENSP00000306760 | Leucine-rich repeat-containing protein 45; Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion |
| LDB2 protein network | https://string-db.org/network/9606.ENSP00000306772 | LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors; Belongs to the LDB family |
| CCDC110 protein network | https://string-db.org/network/9606.ENSP00000306776 | Coiled-coil domain containing 110 |
| ARL6IP1 protein network | https://string-db.org/network/9606.ENSP00000306788 | ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity-dependent m [...] |
| RBKS protein network | https://string-db.org/network/9606.ENSP00000306817 | Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, hist [...] |
| AVEN protein network | https://string-db.org/network/9606.ENSP00000306822 | Cell death regulator Aven; Protects against apoptosis mediated by Apaf-1 |
| SEMA4C protein network | https://string-db.org/network/9606.ENSP00000306844 | Semaphorin-4C; Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-124 [...] |
| VASN protein network | https://string-db.org/network/9606.ENSP00000306864 | Vasorin; May act as an inhibitor of TGF-beta signaling |
| GABARAP protein network | https://string-db.org/network/9606.ENSP00000306866 | Gamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved [...] |
| ZNF565 protein network | https://string-db.org/network/9606.ENSP00000306869 | Zinc finger protein 565; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SEC23A protein network | https://string-db.org/network/9606.ENSP00000306881 | Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| CXCL11 protein network | https://string-db.org/network/9606.ENSP00000306884 | C-X-C motif chemokine 11; Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May p [...] |
| TMEM126A protein network | https://string-db.org/network/9606.ENSP00000306887 | Transmembrane protein 126A; Belongs to the TMEM126 family |
| FAM151A protein network | https://string-db.org/network/9606.ENSP00000306888 | Protein FAM151A; Family with sequence similarity 151 member A; Belongs to the FAM151 family |
| ETV5 protein network | https://string-db.org/network/9606.ENSP00000306894 | ETS translocation variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'; Belongs to the ETS family |
| PRND protein network | https://string-db.org/network/9606.ENSP00000306900 | Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+); Belongs to the prion family |
| RNF181 protein network | https://string-db.org/network/9606.ENSP00000306906 | E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...] |
| PCDHGC4 protein network | https://string-db.org/network/9606.ENSP00000306918 | Protocadherin gamma-C4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| GLB1 protein network | https://string-db.org/network/9606.ENSP00000306920 | Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans; Belongs to the glycosyl hydrolase 35 family |
| CDCA7 protein network | https://string-db.org/network/9606.ENSP00000306968 | Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insuffici [...] |
| OR1N1 protein network | https://string-db.org/network/9606.ENSP00000306974 | Olfactory receptor 1N1; Odorant receptor; Olfactory receptors, family 1 |
| YEATS2 protein network | https://string-db.org/network/9606.ENSP00000306983 | YEATS domain-containing protein 2; Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and bind [...] |
| HAS2 protein network | https://string-db.org/network/9606.ENSP00000306991 | Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most ex [...] |
| MYOZ2 protein network | https://string-db.org/network/9606.ENSP00000306997 | Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...] |
| ESCO2 protein network | https://string-db.org/network/9606.ENSP00000306999 | N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromati [...] |
| APLF protein network | https://string-db.org/network/9606.ENSP00000307004 | Aprataxin and PNK-like factor; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post- [...] |
| KRT73 protein network | https://string-db.org/network/9606.ENSP00000307014 | Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) |
| KLF11 protein network | https://string-db.org/network/9606.ENSP00000307023 | Krueppel-like factor 11; Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like [...] |
| BNC1 protein network | https://string-db.org/network/9606.ENSP00000307041 | Zinc finger protein basonuclin-1; Transcriptional activator (By similarity). Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the ver [...] |
| SDC2 protein network | https://string-db.org/network/9606.ENSP00000307046 | Syndecan-2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity); CD molecules |
| KIF5B protein network | https://string-db.org/network/9606.ENSP00000307078 | Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells [...] |
| MAP6 protein network | https://string-db.org/network/9606.ENSP00000307093 | Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite [...] |
| DEGS2 protein network | https://string-db.org/network/9606.ENSP00000307126 | Sphingolipid delta(4)-desaturase/C4-monooxygenase DES2; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase; Fatty acid desaturases |
| C8orf74 protein network | https://string-db.org/network/9606.ENSP00000307129 | Uncharacterized protein C8orf74; Chromosome 8 open reading frame 74 |
| OR10H3 protein network | https://string-db.org/network/9606.ENSP00000307130 | Olfactory receptor 10H3; Odorant receptor; Olfactory receptors, family 10 |
| CST5 protein network | https://string-db.org/network/9606.ENSP00000307132 | Cystatin-D; Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H [...] |
| CTNND2 protein network | https://string-db.org/network/9606.ENSP00000307134 | Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signaling. It pr [...] |
| TEX37 protein network | https://string-db.org/network/9606.ENSP00000307142 | Testis-expressed sequence 37 protein; Testis expressed 37 |
| DONSON protein network | https://string-db.org/network/9606.ENSP00000307143 | Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for [...] |
| OR8B12 protein network | https://string-db.org/network/9606.ENSP00000307159 | Olfactory receptor 8B12; Odorant receptor; Olfactory receptors, family 8 |
| PATE1 protein network | https://string-db.org/network/9606.ENSP00000307164 | Prostate and testis expressed 1; Belongs to the PATE family |
| FAM103A1 protein network | https://string-db.org/network/9606.ENSP00000307181 | RNMT-activating mini protein; Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap structure of [...] |
| ING2 protein network | https://string-db.org/network/9606.ENSP00000307183 | Inhibitor of growth protein 2; Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like cor [...] |
| ASL protein network | https://string-db.org/network/9606.ENSP00000307188 | Argininosuccinate lyase |
| DNAJB7 protein network | https://string-db.org/network/9606.ENSP00000307197 | DnaJ homolog subfamily B member 7; Probably acts as a co-chaperone; DNAJ heat shock proteins |
| AHSP protein network | https://string-db.org/network/9606.ENSP00000307199 | Alpha-hemoglobin-stabilizing protein; Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglo [...] |
| BPTF protein network | https://string-db.org/network/9606.ENSP00000307208 | Nucleosome-remodeling factor subunit BPTF; Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcripti [...] |
| LCMT2 protein network | https://string-db.org/network/9606.ENSP00000307214 | tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modifie [...] |
| PCDHB1 protein network | https://string-db.org/network/9606.ENSP00000307234 | Protocadherin beta-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| EIF2AK3 protein network | https://string-db.org/network/9606.ENSP00000307235 | Eukaryotic translation initiation factor 2-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha [...] |
| KRT74 protein network | https://string-db.org/network/9606.ENSP00000307240 | Keratin, type II cytoskeletal 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable); Keratins, type [...] |
| PDHB protein network | https://string-db.org/network/9606.ENSP00000307241 | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the gly [...] |
| P2RY12 protein network | https://string-db.org/network/9606.ENSP00000307259 | P2Y purinoceptor 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregati [...] |
| TBL2 protein network | https://string-db.org/network/9606.ENSP00000307260 | Transducin beta-like protein 2; WD repeat domain containing |
| C11orf24 protein network | https://string-db.org/network/9606.ENSP00000307264 | Uncharacterized protein C11orf24; Chromosome 11 open reading frame 24 |
| IRF2BP1 protein network | https://string-db.org/network/9606.ENSP00000307265 | Interferon regulatory factor 2-binding protein 1; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. May act as [...] |
| RPTOR protein network | https://string-db.org/network/9606.ENSP00000307272 | Regulatory-associated protein of mTOR; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response [...] |
| SCAMP3 protein network | https://string-db.org/network/9606.ENSP00000307275 | Secretory carrier-associated membrane protein 3; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family |
| MYL1 protein network | https://string-db.org/network/9606.ENSP00000307280 | Myosin light chain 1/3, skeletal muscle isoform; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing |
| MCM7 protein network | https://string-db.org/network/9606.ENSP00000307288 | DNA replication licensing factor MCM7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| PRKCDBP protein network | https://string-db.org/network/9606.ENSP00000307292 | Caveolae-associated protein 3; Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue- specific manner. Required for the formation of caveolae in smooth m [...] |
| CHST14 protein network | https://string-db.org/network/9606.ENSP00000307297 | Carbohydrate sulfotransferase 14; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-s [...] |
| FEM1B protein network | https://string-db.org/network/9606.ENSP00000307298 | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associate [...] |
| DDIT4 protein network | https://string-db.org/network/9606.ENSP00000307305 | DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of [...] |
| HOXC10 protein network | https://string-db.org/network/9606.ENSP00000307321 | Homeobox protein Hox-C10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| HCN1 protein network | https://string-db.org/network/9606.ENSP00000307342 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to [...] |
| SHE protein network | https://string-db.org/network/9606.ENSP00000307369 | SH2 domain-containing adapter protein E; Src homology 2 domain containing E |
| MLLT10 protein network | https://string-db.org/network/9606.ENSP00000307411 | Protein AF-10; Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA; PHD finger proteins |
| MGAT2 protein network | https://string-db.org/network/9606.ENSP00000307423 | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans; Mannosyl-glycoprotein N-acetylglucosa [...] |
| SLC22A25 protein network | https://string-db.org/network/9606.ENSP00000307443 | Solute carrier family 22 member 25; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family |
| NECAB2 protein network | https://string-db.org/network/9606.ENSP00000307449 | N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling effici [...] |
| KIAA1024 protein network | https://string-db.org/network/9606.ENSP00000307461 | Intrinsically disordered protein which may negatively regulate mTOR signaling pathway by stabilizing the mTOR complex component DEPTOR . Negatively regulates angiogenesis . Negatively regulates c [...] |
| ARNT2 protein network | https://string-db.org/network/9606.ENSP00000307479 | Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal functio [...] |
| WDR48 protein network | https://string-db.org/network/9606.ENSP00000307491 | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost in [...] |
| CALB2 protein network | https://string-db.org/network/9606.ENSP00000307508 | Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons; EF-hand domain containing |
| MRC2 protein network | https://string-db.org/network/9606.ENSP00000307513 | C-type mannose receptor 2; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release [...] |
| OR9G4 protein network | https://string-db.org/network/9606.ENSP00000307515 | Olfactory receptor 9G4; Odorant receptor; Olfactory receptors, family 9 |
| TMPRSS11E protein network | https://string-db.org/network/9606.ENSP00000307519 | Transmembrane protease serine 11E; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position |
| CST2 protein network | https://string-db.org/network/9606.ENSP00000307540 | Cystatin-SA; Thiol protease inhibitor; Cystatins, type 2 |
| NPTX1 protein network | https://string-db.org/network/9606.ENSP00000307549 | Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitat [...] |
| NINJ2 protein network | https://string-db.org/network/9606.ENSP00000307552 | Ninjurin-2; Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues |
| QARS protein network | https://string-db.org/network/9606.ENSP00000307567 | Glutamine--tRNA ligase; Glutamine--tRNA ligase. Plays a critical role in brain development; Belongs to the class-I aminoacyl-tRNA synthetase family |
| OR9K2 protein network | https://string-db.org/network/9606.ENSP00000307598 | Olfactory receptor 9K2; Odorant receptor; Olfactory receptors, family 9 |
| SCN11A protein network | https://string-db.org/network/9606.ENSP00000307599 | Sodium channel protein type 11 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to th [...] |
| ZBTB5 protein network | https://string-db.org/network/9606.ENSP00000307604 | Zinc finger and BTB domain-containing protein 5; May be involved in transcriptional regulation; BTB domain containing |
| SDR16C5 protein network | https://string-db.org/network/9606.ENSP00000307607 | Epidermal retinol dehydrogenase 2; Oxidoreductase with strong preference for NAD. Active in both the oxidative and reductive directions. Oxidizes all-trans- retinol in all-trans-retinaldehyde. No [...] |
| AGAP1 protein network | https://string-db.org/network/9606.ENSP00000307634 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP [...] |
| MORN4 protein network | https://string-db.org/network/9606.ENSP00000307636 | MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma |
| TTC36 protein network | https://string-db.org/network/9606.ENSP00000307640 | Tetratricopeptide repeat domain containing |
| CCDC132 protein network | https://string-db.org/network/9606.ENSP00000307666 | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized transferr [...] |
| CANT1 protein network | https://string-db.org/network/9606.ENSP00000307674 | Soluble calcium-activated nucleotidase 1; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity [...] |
| TADA3 protein network | https://string-db.org/network/9606.ENSP00000307684 | Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be consid [...] |
| KCNS1 protein network | https://string-db.org/network/9606.ENSP00000307694 | Potassium voltage-gated channel subfamily S member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB [...] |
| ACOX2 protein network | https://string-db.org/network/9606.ENSP00000307697 | Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids; Belongs to the acyl-CoA oxidase family |
| TSPAN5 protein network | https://string-db.org/network/9606.ENSP00000307701 | Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44; Tetraspanins |
| HIST1H1E protein network | https://string-db.org/network/9606.ENSP00000307705 | Histone H1.4; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...] |
| MT1E protein network | https://string-db.org/network/9606.ENSP00000307706 | Metallothionein-1E; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| HMP19 protein network | https://string-db.org/network/9606.ENSP00000307722 | Neuronal vesicle trafficking-associated protein 2; Neuron-specific protein family member 2 |
| OR2C1 protein network | https://string-db.org/network/9606.ENSP00000307726 | Olfactory receptor 2C1; Odorant receptor; Olfactory receptors, family 2 |
| CMTM8 protein network | https://string-db.org/network/9606.ENSP00000307741 | CKLF like MARVEL transmembrane domain containing 8; Belongs to the chemokine-like factor family |
| ZNF608 protein network | https://string-db.org/network/9606.ENSP00000307746 | Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription; Zinc fingers C2H2-type |
| HTR1E protein network | https://string-db.org/network/9606.ENSP00000307766 | 5-hydroxytryptamine receptor 1E; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding cau [...] |
| ZNF239 protein network | https://string-db.org/network/9606.ENSP00000307774 | Zinc finger protein 239; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CYCS protein network | https://string-db.org/network/9606.ENSP00000307786 | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrom [...] |
| ZPLD1 protein network | https://string-db.org/network/9606.ENSP00000307801 | Zona pellucida-like domain-containing protein 1; Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ |
| NPFFR2 protein network | https://string-db.org/network/9606.ENSP00000307822 | Neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occu [...] |
| GPR113 protein network | https://string-db.org/network/9606.ENSP00000307831 | Adhesion G-protein coupled receptor F3; Orphan receptor |
| FBXO22 protein network | https://string-db.org/network/9606.ENSP00000307833 | F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric prot [...] |
| DRAP1 protein network | https://string-db.org/network/9606.ENSP00000307850 | Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction [...] |
| MUS81 protein network | https://string-db.org/network/9606.ENSP00000307853 | Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branc [...] |
| PCMTD2 protein network | https://string-db.org/network/9606.ENSP00000307854 | protein-L-isoaspartate O-methyltransferase domain containing 2; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family |
| ZBTB4 protein network | https://string-db.org/network/9606.ENSP00000307858 | Zinc finger and BTB domain-containing protein 4; Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affi [...] |
| DIRC1 protein network | https://string-db.org/network/9606.ENSP00000307860 | Disrupted in renal carcinoma 1 |
| U2AF2 protein network | https://string-db.org/network/9606.ENSP00000307863 | Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD [...] |
| C11orf45 protein network | https://string-db.org/network/9606.ENSP00000307879 | Putative uncharacterized protein C11orf45; Chromosome 11 open reading frame 45 |
| RPL13 protein network | https://string-db.org/network/9606.ENSP00000307889 | Ribosomal protein L13 |
| GLUL protein network | https://string-db.org/network/9606.ENSP00000307900 | Glutamine synthetase; This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent m [...] |
| CHST2 protein network | https://string-db.org/network/9606.ENSP00000307911 | Carbohydrate sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...] |
| GCC2 protein network | https://string-db.org/network/9606.ENSP00000307939 | GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the [...] |
| EEF2 protein network | https://string-db.org/network/9606.ENSP00000307940 | Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- [...] |
| HIGD2B protein network | https://string-db.org/network/9606.ENSP00000307951 | HIG1 hypoxia inducible domain family member 2B |
| FAM174A protein network | https://string-db.org/network/9606.ENSP00000307954 | Membrane protein FAM174A; Family with sequence similarity 174 member A |
| IQCF1 protein network | https://string-db.org/network/9606.ENSP00000307958 | IQ domain-containing protein F1; Involved in sperm capacitation and acrosome reaction |
| DST protein network | https://string-db.org/network/9606.ENSP00000307959 | Dystonin; Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the ac [...] |
| RFNG protein network | https://string-db.org/network/9606.ENSP00000307971 | Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of [...] |
| METTL18 protein network | https://string-db.org/network/9606.ENSP00000307975 | Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase |
| TUT1 protein network | https://string-db.org/network/9606.ENSP00000308000 | Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates [...] |
| PABPC5 protein network | https://string-db.org/network/9606.ENSP00000308012 | Polyadenylate-binding protein 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than [...] |
| TADA2B protein network | https://string-db.org/network/9606.ENSP00000308022 | Transcriptional adapter 2-beta; Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2; Myb/SANT domain containing |
| PCSK1 protein network | https://string-db.org/network/9606.ENSP00000308024 | Neuroendocrine convertase 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephali [...] |
| CYP2S1 protein network | https://string-db.org/network/9606.ENSP00000308032 | Cytochrome P450 2S1; Has a potential importance for extrahepatic xenobiotic metabolism; Cytochrome P450 family 2 |
| SNCB protein network | https://string-db.org/network/9606.ENSP00000308057 | Beta-synuclein; Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamin [...] |
| OR10P1 protein network | https://string-db.org/network/9606.ENSP00000308082 | Olfactory receptor 10P1; Odorant receptor; Olfactory receptors, family 10 |
| CD248 protein network | https://string-db.org/network/9606.ENSP00000308117 | Endosialin; May play a role in tumor angiogenesis; C-type lectin domain containing |
| ATP6V0A4 protein network | https://string-db.org/network/9606.ENSP00000308122 | V-type proton ATPase 116 kDa subunit a isoform 4; Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney; V-type ATPases |
| AMZ1 protein network | https://string-db.org/network/9606.ENSP00000308149 | Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2; Belongs to the peptidase M54 family |
| WDR3 protein network | https://string-db.org/network/9606.ENSP00000308179 | WD repeat-containing protein 3; WD repeat domain containing; Belongs to the WD repeat WDR3/UTP12 family |
| RNASEH2C protein network | https://string-db.org/network/9606.ENSP00000308193 | Ribonuclease H2 subunit C; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the rem [...] |
| MMP14 protein network | https://string-db.org/network/9606.ENSP00000308208 | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and [...] |
| RGMB protein network | https://string-db.org/network/9606.ENSP00000308219 | RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogeneti [...] |
| COMMD1 protein network | https://string-db.org/network/9606.ENSP00000308236 | COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitinatio [...] |
| PTDSS2 protein network | https://string-db.org/network/9606.ENSP00000308258 | Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is spe [...] |
| OR5B3 protein network | https://string-db.org/network/9606.ENSP00000308270 | Olfactory receptor 5B3; Odorant receptor; Olfactory receptors, family 5 |
| MRPL38 protein network | https://string-db.org/network/9606.ENSP00000308275 | Mitochondrial ribosomal protein L38; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily |
| C9orf131 protein network | https://string-db.org/network/9606.ENSP00000308279 | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131 |
| FAM170B protein network | https://string-db.org/network/9606.ENSP00000308292 | Protein FAM170B; Plays a role in fertilization through the acrosome reaction; Belongs to the FAM170 family |
| PODN protein network | https://string-db.org/network/9606.ENSP00000308315 | Podocan; Negatively regulates cell proliferation and cell migration; Small leucine rich repeat proteoglycans |
| PPP1R3B protein network | https://string-db.org/network/9606.ENSP00000308318 | Protein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its [...] |
| MYEOV protein network | https://string-db.org/network/9606.ENSP00000308330 | Myeloma-overexpressed gene protein; Myeloma overexpressed |
| UTP23 protein network | https://string-db.org/network/9606.ENSP00000308332 | rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis; Belongs to the UTP23/FCF1 family. UTP23 subfamily |
| ATP5S protein network | https://string-db.org/network/9606.ENSP00000308334 | ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP syn [...] |
| SEC16B protein network | https://string-db.org/network/9606.ENSP00000308339 | Protein transport protein Sec16B; Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus and for normal transitional endoplasmic reticulum (tER) organization; [...] |
| MLKL protein network | https://string-db.org/network/9606.ENSP00000308351 | Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to [...] |
| TIGD3 protein network | https://string-db.org/network/9606.ENSP00000308354 | Tigger transposable element-derived protein 3; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| P2RY14 protein network | https://string-db.org/network/9606.ENSP00000308361 | P2Y purinoceptor 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP; P2Y receptors |
| C12orf76 protein network | https://string-db.org/network/9606.ENSP00000308368 | Uncharacterized protein C12orf76; Chromosome 12 open reading frame 76 |
| LEMD3 protein network | https://string-db.org/network/9606.ENSP00000308369 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced ce [...] |
| H2AFV protein network | https://string-db.org/network/9606.ENSP00000308405 | Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machiner [...] |
| RPS6KB2 protein network | https://string-db.org/network/9606.ENSP00000308413 | Ribosomal protein S6 kinase beta-2; Phosphorylates specifically ribosomal protein S6 |
| CYB5B protein network | https://string-db.org/network/9606.ENSP00000308430 | Cytochrome b5 type B; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases |
| KRT17 protein network | https://string-db.org/network/9606.ENSP00000308452 | Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair (By similarity). Re [...] |
| RND1 protein network | https://string-db.org/network/9606.ENSP00000308461 | Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac [...] |
| EIF4EBP3 protein network | https://string-db.org/network/9606.ENSP00000308472 | Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphoryla [...] |
| GPR171 protein network | https://string-db.org/network/9606.ENSP00000308479 | Probable G-protein coupled receptor 171; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ARL10 protein network | https://string-db.org/network/9606.ENSP00000308496 | ADP-ribosylation factor-like protein 10; ADP ribosylation factor like GTPase 10; Belongs to the small GTPase superfamily. Arf family |
| DCAKD protein network | https://string-db.org/network/9606.ENSP00000308515 | dephospho-CoA kinase domain containing |
| GEMIN2 protein network | https://string-db.org/network/9606.ENSP00000308533 | Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...] |
| GOLT1A protein network | https://string-db.org/network/9606.ENSP00000308535 | Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex |
| F2 protein network | https://string-db.org/network/9606.ENSP00000308541 | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in [...] |
| MEPCE protein network | https://string-db.org/network/9606.ENSP00000308546 | 7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it |
| ZNHIT2 protein network | https://string-db.org/network/9606.ENSP00000308548 | Zinc finger HIT-type containing 2 |
| RHOD protein network | https://string-db.org/network/9606.ENSP00000308576 | Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of ac [...] |
| ZNF431 protein network | https://string-db.org/network/9606.ENSP00000308578 | Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transc [...] |
| APITD1 protein network | https://string-db.org/network/9606.ENSP00000308583 | Centromere protein S; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 comple [...] |
| GAL3ST3 protein network | https://string-db.org/network/9606.ENSP00000308591 | Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-Glc [...] |
| OR5R1 protein network | https://string-db.org/network/9606.ENSP00000308595 | Olfactory receptor 5R1; Odorant receptor; Olfactory receptors, family 5 |
| DLEC1 protein network | https://string-db.org/network/9606.ENSP00000308597 | Deleted in lung and esophageal cancer protein 1; May act as a tumor suppressor by inhibiting cell proliferation; Cilia and flagella associated |
| AGR3 protein network | https://string-db.org/network/9606.ENSP00000308606 | Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calci [...] |
| GPD2 protein network | https://string-db.org/network/9606.ENSP00000308610 | Glycerol-3-phosphate dehydrogenase, mitochondrial; Glycerol-3-phosphate dehydrogenase 2; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family |
| GLE1 protein network | https://string-db.org/network/9606.ENSP00000308622 | Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear por [...] |
| OR10AD1 protein network | https://string-db.org/network/9606.ENSP00000308689 | Olfactory receptor 10AD1; Odorant receptor; Olfactory receptors, family 10 |
| DPY19L1 protein network | https://string-db.org/network/9606.ENSP00000308695 | Probable C-mannosyltransferase DPY19L1; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins |
| TCP11 protein network | https://string-db.org/network/9606.ENSP00000308708 | T-complex protein 11 homolog; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membr [...] |
| OR9Q2 protein network | https://string-db.org/network/9606.ENSP00000308714 | Olfactory receptor 9Q2; Odorant receptor; Olfactory receptors, family 9 |
| INHBC protein network | https://string-db.org/network/9606.ENSP00000308716 | Inhibin beta C chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diver [...] |
| MRPL48 protein network | https://string-db.org/network/9606.ENSP00000308717 | Mitochondrial ribosomal protein L48 |
| PRSS1 protein network | https://string-db.org/network/9606.ENSP00000308720 | Trypsin-1; Has activity against the synthetic substrates Boc-Phe- Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val- Pro-Arg-Mec. The single-chain form is more active than the two [...] |
| GABRB3 protein network | https://string-db.org/network/9606.ENSP00000308725 | Gamma-aminobutyric acid receptor subunit beta-3; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine re [...] |
| SUSD5 protein network | https://string-db.org/network/9606.ENSP00000308727 | Sushi domain containing 5 |
| GPR151 protein network | https://string-db.org/network/9606.ENSP00000308733 | Probable G-protein coupled receptor 151; Orphan receptor; G protein-coupled receptors, Class A orphans |
| CLOCK protein network | https://string-db.org/network/9606.ENSP00000308741 | Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates va [...] |
| CBX2 protein network | https://string-db.org/network/9606.ENSP00000308750 | Chromobox protein homolog 2; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| TMOD3 protein network | https://string-db.org/network/9606.ENSP00000308753 | Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in t [...] |
| ZBTB21 protein network | https://string-db.org/network/9606.ENSP00000308759 | Zinc finger and BTB domain-containing protein 21; Acts as a transcription repressor; BTB domain containing |
| OR52I2 protein network | https://string-db.org/network/9606.ENSP00000308764 | Olfactory receptor 52I2; Odorant receptor; Olfactory receptors, family 52 |
| SULT1B1 protein network | https://string-db.org/network/9606.ENSP00000308770 | Sulfotransferase family cytosolic 1B member 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurot [...] |
| ANKS4B protein network | https://string-db.org/network/9606.ENSP00000308772 | Ankyrin repeat and SAM domain-containing protein 4B; As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organiza [...] |
| GP6 protein network | https://string-db.org/network/9606.ENSP00000308782 | Platelet glycoprotein VI; Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin fo [...] |
| CCL19 protein network | https://string-db.org/network/9606.ENSP00000308815 | C-C motif chemokine 19; May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T [...] |
| RIC3 protein network | https://string-db.org/network/9606.ENSP00000308820 | Protein RIC-3; Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotonin [...] |
| CCDC74B protein network | https://string-db.org/network/9606.ENSP00000308873 | Coiled-coil domain containing 74B |
| SNED1 protein network | https://string-db.org/network/9606.ENSP00000308893 | Sushi, nidogen and EGF-like domain-containing protein 1; Fibronectin type III domain containing |
| SLC19A1 protein network | https://string-db.org/network/9606.ENSP00000308895 | Folate transporter 1; Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples thr [...] |
| MRPL11 protein network | https://string-db.org/network/9606.ENSP00000308897 | Mitochondrial ribosomal protein L11; Belongs to the universal ribosomal protein uL11 family |
| GPR148 protein network | https://string-db.org/network/9606.ENSP00000308908 | Probable G-protein coupled receptor 148; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ZCCHC12 protein network | https://string-db.org/network/9606.ENSP00000308921 | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMA [...] |
| TLR10 protein network | https://string-db.org/network/9606.ENSP00000308925 | Toll-like receptor 10; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response [...] |
| PPM1J protein network | https://string-db.org/network/9606.ENSP00000308926 | Belongs to the PP2C family |
| PLG protein network | https://string-db.org/network/9606.ENSP00000308938 | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and i [...] |
| HLTF protein network | https://string-db.org/network/9606.ENSP00000308944 | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for trans [...] |
| PSG1 protein network | https://string-db.org/network/9606.ENSP00000308970 | Pregnancy specific beta-1-glycoprotein 1; Belongs to the immunoglobulin superfamily. CEA family |
| VWC2L protein network | https://string-db.org/network/9606.ENSP00000308976 | Von Willebrand factor C domain-containing protein 2-like; May play a role in neurogenesis. May play a role in bone differentiation and matrix mineralization |
| THAP6 protein network | https://string-db.org/network/9606.ENSP00000309007 | THAP domain containing 6 |
| OR9G1 protein network | https://string-db.org/network/9606.ENSP00000309012 | Olfactory receptor 9G1; Odorant receptor; Olfactory receptors, family 9 |
| VCPIP1 protein network | https://string-db.org/network/9606.ENSP00000309031 | Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitiona [...] |
| TSPAN17 protein network | https://string-db.org/network/9606.ENSP00000309036 | Tetraspanin-17; Regulates ADAM10 maturation; Belongs to the tetraspanin (TM4SF) family |
| CATSPER1 protein network | https://string-db.org/network/9606.ENSP00000309052 | Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...] |
| PLAC8L1 protein network | https://string-db.org/network/9606.ENSP00000309087 | PLAC8-like protein 1; PLAC8 like 1; Belongs to the cornifelin family |
| GMPPB protein network | https://string-db.org/network/9606.ENSP00000309092 | Mannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids; Belongs to the transferase hexapept [...] |
| B3GNT1 protein network | https://string-db.org/network/9606.ENSP00000309096 | Beta-1,4-glucuronyltransferase 1; Beta-1,4-glucuronyltransferase involved in O- mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor [...] |
| PTPN7 protein network | https://string-db.org/network/9606.ENSP00000309116 | Tyrosine-protein phosphatase non-receptor type 7; Protein phosphatase that acts preferentially on tyrosine-phosphorylated MAPK1. Plays a role in the regulation of T and B-lymphocyte development a [...] |
| RBFOX1 protein network | https://string-db.org/network/9606.ENSP00000309117 | RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons a [...] |
| OLR1 protein network | https://string-db.org/network/9606.ENSP00000309124 | Oxidized low-density lipoprotein receptor 1; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelia [...] |
| NSUN5 protein network | https://string-db.org/network/9606.ENSP00000309126 | Probable 28S rRNA (cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 in 28S rRNA |
| BCL2L14 protein network | https://string-db.org/network/9606.ENSP00000309132 | Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis; Belongs to the Bcl-2 family |
| MARCH3 protein network | https://string-db.org/network/9606.ENSP00000309141 | E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in th [...] |
| PDE12 protein network | https://string-db.org/network/9606.ENSP00000309142 | 2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modula [...] |
| ZNF471 protein network | https://string-db.org/network/9606.ENSP00000309161 | Zinc finger protein 471; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RCE1 protein network | https://string-db.org/network/9606.ENSP00000309163 | CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 |
| EIF1AD protein network | https://string-db.org/network/9606.ENSP00000309175 | Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation |
| SH3RF3 protein network | https://string-db.org/network/9606.ENSP00000309186 | SH3 domain containing ring finger 3 |
| SPERT protein network | https://string-db.org/network/9606.ENSP00000309189 | Spermatid-associated protein; Spermatid associated |
| UBE3C protein network | https://string-db.org/network/9606.ENSP00000309198 | Ubiquitin-protein ligase E3C; E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquit [...] |
| POMZP3 protein network | https://string-db.org/network/9606.ENSP00000309233 | POM121 and ZP3 fusion |
| USP48 protein network | https://string-db.org/network/9606.ENSP00000309262 | Ubiquitin carboxyl-terminal hydrolase 48; Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that [...] |
| CHST1 protein network | https://string-db.org/network/9606.ENSP00000309270 | Carbohydrate sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) resid [...] |
| CCDC96 protein network | https://string-db.org/network/9606.ENSP00000309285 | Coiled-coil domain containing 96 |
| ZNF680 protein network | https://string-db.org/network/9606.ENSP00000309330 | Zinc finger protein 680; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RPL15 protein network | https://string-db.org/network/9606.ENSP00000309334 | Ribosomal protein L15 |
| HOXC5 protein network | https://string-db.org/network/9606.ENSP00000309336 | Homeobox protein Hox-C5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| CLCF1 protein network | https://string-db.org/network/9606.ENSP00000309338 | Cardiotrophin-like cytokine factor 1; Cytokine with B-cell stimulating capability. Binds to and activates the ILST/gp130 receptor; Interleukin 6 type cytokine family |
| CD164 protein network | https://string-db.org/network/9606.ENSP00000309376 | Sialomucin core protein 24; Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and by negatively regulating CD34(+)CD38(lo/-) cell pr [...] |
| TRAM1L1 protein network | https://string-db.org/network/9606.ENSP00000309402 | Translocating chain-associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; TLC domain containing |
| CLTB protein network | https://string-db.org/network/9606.ENSP00000309415 | Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family |
| ZDHHC24 protein network | https://string-db.org/network/9606.ENSP00000309429 | Probable palmitoyltransferase ZDHHC24; Zinc finger DHHC-type containing 24; Belongs to the DHHC palmitoyltransferase family |
| PIGS protein network | https://string-db.org/network/9606.ENSP00000309430 | GPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates; Belongs to the PIGS f [...] |
| TUBB8B protein network | https://string-db.org/network/9606.ENSP00000309431 | Tubulin beta-8 chain-like protein LOC260334; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeab [...] |
| FAM134C protein network | https://string-db.org/network/9606.ENSP00000309432 | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family |
| HOXB9 protein network | https://string-db.org/network/9606.ENSP00000309439 | Homeobox protein Hox-B9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| VPS41 protein network | https://string-db.org/network/9606.ENSP00000309457 | Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...] |
| LIPT2 protein network | https://string-db.org/network/9606.ENSP00000309463 | Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes, [...] |
| PSMD1 protein network | https://string-db.org/network/9606.ENSP00000309474 | 26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| ACO1 protein network | https://string-db.org/network/9606.ENSP00000309477 | Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, seques [...] |
| GPRC6A protein network | https://string-db.org/network/9606.ENSP00000309493 | G-protein coupled receptor family C group 6 member A; Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar am [...] |
| NWD2 protein network | https://string-db.org/network/9606.ENSP00000309501 | NACHT and WD repeat domain containing 2 |
| SLC26A7 protein network | https://string-db.org/network/9606.ENSP00000309504 | Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the e [...] |
| PHYHD1 protein network | https://string-db.org/network/9606.ENSP00000309515 | Phytanoyl-CoA dioxygenase domain-containing protein 1; Isoform 1 has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is no [...] |
| LIME1 protein network | https://string-db.org/network/9606.ENSP00000309521 | Lck-interacting transmembrane adapter 1; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absenc [...] |
| CSHL1 protein network | https://string-db.org/network/9606.ENSP00000309524 | Chorionic somatomammotropin hormone-like 1; May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation; Growth hormone family |
| DAPL1 protein network | https://string-db.org/network/9606.ENSP00000309538 | Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis |
| DPYSL2 protein network | https://string-db.org/network/9606.ENSP00000309539 | Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for s [...] |
| PGA5 protein network | https://string-db.org/network/9606.ENSP00000309542 | Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent |
| PDP2 protein network | https://string-db.org/network/9606.ENSP00000309548 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate [...] |
| HCFC1 protein network | https://string-db.org/network/9606.ENSP00000309555 | Host cell factor 1; Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to [...] |
| C19orf70 protein network | https://string-db.org/network/9606.ENSP00000309561 | MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| UQCRH protein network | https://string-db.org/network/9606.ENSP00000309565 | Cytochrome b-c1 complex subunit 6, mitochondrial; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial [...] |
| KLF7 protein network | https://string-db.org/network/9606.ENSP00000309570 | Krueppel-like factor 7; Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence; Kruppel like factors |
| TERT protein network | https://string-db.org/network/9606.ENSP00000309572 | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, [...] |
| PRKACA protein network | https://string-db.org/network/9606.ENSP00000309591 | cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regu [...] |
| C10orf2 protein network | https://string-db.org/network/9606.ENSP00000309595 | Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime mai [...] |
| MAP3K11 protein network | https://string-db.org/network/9606.ENSP00000309597 | Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), [...] |
| ZNF408 protein network | https://string-db.org/network/9606.ENSP00000309606 | Zinc finger protein 408; May be involved in transcriptional regulation; PR/SET domain family |
| METTL2A protein network | https://string-db.org/network/9606.ENSP00000309610 | Methyltransferase-like protein 2A; Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs |
| XXYLT1 protein network | https://string-db.org/network/9606.ENSP00000309640 | Xyloside xylosyltransferase 1; Alpha-1,3-xylosyltransferase, which elongates the O- linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins [...] |
| BOD1 protein network | https://string-db.org/network/9606.ENSP00000309644 | Biorientation of chromosomes in cell division protein 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles |
| CA5A protein network | https://string-db.org/network/9606.ENSP00000309649 | Carbonic anhydrase 5A, mitochondrial; Reversible hydration of carbon dioxide. Low activity; Carbonic anhydrases |
| GLIS1 protein network | https://string-db.org/network/9606.ENSP00000309653 | Zinc finger protein GLIS1; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity); Zinc fingers C2H2-type |
| OR52W1 protein network | https://string-db.org/network/9606.ENSP00000309673 | Olfactory receptor 52W1; Odorant receptor; Olfactory receptors, family 52 |
| LRCH4 protein network | https://string-db.org/network/9606.ENSP00000309689 | Leucine rich repeats and calponin homology domain containing 4 |
| SH3PXD2B protein network | https://string-db.org/network/9606.ENSP00000309714 | SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidas [...] |
| SLCO4C1 protein network | https://string-db.org/network/9606.ENSP00000309741 | Solute carrier organic anion transporter family member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAM [...] |
| APOBEC3F protein network | https://string-db.org/network/9606.ENSP00000309749 | DNA dC->dU-editing enzyme APOBEC-3F; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| SLC16A13 protein network | https://string-db.org/network/9606.ENSP00000309751 | Monocarboxylate transporter 13; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Belongs to the major facilitator superfamily. [...] |
| LPL protein network | https://string-db.org/network/9606.ENSP00000309757 | Lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteog [...] |
| NLRP6 protein network | https://string-db.org/network/9606.ENSP00000309767 | NACHT, LRR and PYD domains-containing protein 6; As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...] |
| CPED1 protein network | https://string-db.org/network/9606.ENSP00000309772 | Cadherin like and PC-esterase domain containing 1 |
| MRGPRF protein network | https://string-db.org/network/9606.ENSP00000309782 | Mas-related G-protein coupled receptor member F; Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain [...] |
| MIS18BP1 protein network | https://string-db.org/network/9606.ENSP00000309790 | Mis18-binding protein 1; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis; Myb/SANT domain containing |
| TMEM234 protein network | https://string-db.org/network/9606.ENSP00000309792 | Belongs to the TMEM234 family |
| TBC1D16 protein network | https://string-db.org/network/9606.ENSP00000309794 | TBC1 domain family member 16; May act as a GTPase-activating protein for Rab family protein(s) |
| RPL38 protein network | https://string-db.org/network/9606.ENSP00000309830 | Ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family |
| CCDC13 protein network | https://string-db.org/network/9606.ENSP00000309836 | Coiled-coil domain-containing protein 13; Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia |
| NARF protein network | https://string-db.org/network/9606.ENSP00000309899 | Nuclear prelamin A recognition factor; Belongs to the NARF family |
| TBX5 protein network | https://string-db.org/network/9606.ENSP00000309913 | T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif [...] |
| SPNS1 protein network | https://string-db.org/network/9606.ENSP00000309945 | Protein spinster homolog 1; Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death |
| EFEMP2 protein network | https://string-db.org/network/9606.ENSP00000309953 | EGF containing fibulin extracellular matrix protein 2; Belongs to the fibulin family |
| ADAM17 protein network | https://string-db.org/network/9606.ENSP00000309968 | Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble [...] |
| CNIH2 protein network | https://string-db.org/network/9606.ENSP00000310003 | Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modula [...] |
| NR1D2 protein network | https://string-db.org/network/9606.ENSP00000310006 | Nuclear receptor subfamily 1 group D member 2; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex tr [...] |
| SWSAP1 protein network | https://string-db.org/network/9606.ENSP00000310008 | ATPase SWSAP1; ATPase which is preferentially stimulated by single- stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its A [...] |
| ADAT1 protein network | https://string-db.org/network/9606.ENSP00000310015 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA |
| CD34 protein network | https://string-db.org/network/9606.ENSP00000310036 | Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or dire [...] |
| ZNF622 protein network | https://string-db.org/network/9606.ENSP00000310042 | Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development |
| FAM53A protein network | https://string-db.org/network/9606.ENSP00000310057 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle |
| TAOK2 protein network | https://string-db.org/network/9606.ENSP00000310094 | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 M [...] |
| TMEM255A protein network | https://string-db.org/network/9606.ENSP00000310110 | Transmembrane protein 255A; Belongs to the TMEM255 family |
| HSPB7 protein network | https://string-db.org/network/9606.ENSP00000310111 | Heat shock protein family B member 7 |
| PPP1R14B protein network | https://string-db.org/network/9606.ENSP00000310117 | Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity) |
| ALG10B protein network | https://string-db.org/network/9606.ENSP00000310120 | Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide pre [...] |
| PSMD2 protein network | https://string-db.org/network/9606.ENSP00000310129 | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| CYP2W1 protein network | https://string-db.org/network/9606.ENSP00000310149 | Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of [...] |
| FOSL1 protein network | https://string-db.org/network/9606.ENSP00000310170 | Fos-related antigen 1; FOS like 1, AP-1 transcription factor subunit; Belongs to the bZIP family. Fos subfamily |
| C4orf32 protein network | https://string-db.org/network/9606.ENSP00000310182 | Uncharacterized protein FAM241A; Chromosome 4 open reading frame 32 |
| NRIP3 protein network | https://string-db.org/network/9606.ENSP00000310205 | Nuclear receptor interacting protein 3 |
| SLC5A6 protein network | https://string-db.org/network/9606.ENSP00000310208 | Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Solute carriers |
| KLRC4 protein network | https://string-db.org/network/9606.ENSP00000310216 | NKG2-F type II integral membrane protein; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells; Killer cell lectin like receptors |
| HSPA6 protein network | https://string-db.org/network/9606.ENSP00000310219 | Heat shock 70 kDa protein 6; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized p [...] |
| RAB1B protein network | https://string-db.org/network/9606.ENSP00000310226 | Ras-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| SLC22A13 protein network | https://string-db.org/network/9606.ENSP00000310241 | Solute carrier family 22 member 13 |
| RASGRP1 protein network | https://string-db.org/network/9606.ENSP00000310244 | RAS guanyl-releasing protein 1; Functions as a calcium- and diacylglycerol (DAG)- regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activ [...] |
| GPR152 protein network | https://string-db.org/network/9606.ENSP00000310255 | Probable G-protein coupled receptor 152; Orphan receptor; G protein-coupled receptors, Class A orphans |
| INTS6 protein network | https://string-db.org/network/9606.ENSP00000310260 | Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| TNFRSF10D protein network | https://string-db.org/network/9606.ENSP00000310263 | Tumor necrosis factor receptor superfamily member 10D; Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects again [...] |
| BANF1 protein network | https://string-db.org/network/9606.ENSP00000310275 | Barrier-to-autointegration factor; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be inv [...] |
| SP3 protein network | https://string-db.org/network/9606.ENSP00000310301 | Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements [...] |
| TOPAZ1 protein network | https://string-db.org/network/9606.ENSP00000310303 | Testis- and ovary-specific PAZ domain-containing protein 1; Testis and ovary specific PAZ domain containing 1 |
| P2RY2 protein network | https://string-db.org/network/9606.ENSP00000310305 | P2Y purinoceptor 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylt [...] |
| FBXO45 protein network | https://string-db.org/network/9606.ENSP00000310332 | F-box/SPRY domain-containing protein 1; Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Play [...] |
| REP15 protein network | https://string-db.org/network/9606.ENSP00000310335 | Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment |
| OR4S2 protein network | https://string-db.org/network/9606.ENSP00000310337 | Olfactory receptor 4S2; Odorant receptor; Olfactory receptors, family 4 |
| KIAA1551 protein network | https://string-db.org/network/9606.ENSP00000310338 | Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the en [...] |
| RMI2 protein network | https://string-db.org/network/9606.ENSP00000310356 | RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is requi [...] |
| MLC1 protein network | https://string-db.org/network/9606.ENSP00000310375 | Membrane protein MLC1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx |
| XCR1 protein network | https://string-db.org/network/9606.ENSP00000310405 | Chemokine XC receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin; X-C motif ch [...] |
| RIN1 protein network | https://string-db.org/network/9606.ENSP00000310406 | Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First [...] |
| LMAN1L protein network | https://string-db.org/network/9606.ENSP00000310431 | Protein ERGIC-53-like; Lectin, mannose binding 1 like |
| AIM1L protein network | https://string-db.org/network/9606.ENSP00000310435 | Beta/gamma crystallin domain-containing protein 2; Absent in melanoma 1-like; Belongs to the beta/gamma-crystallin family |
| GLS2 protein network | https://string-db.org/network/9606.ENSP00000310447 | Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing [...] |
| SART1 protein network | https://string-db.org/network/9606.ENSP00000310448 | U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA; Belongs to th [...] |
| AKIP1 protein network | https://string-db.org/network/9606.ENSP00000310459 | A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRK [...] |
| ZNF624 protein network | https://string-db.org/network/9606.ENSP00000310472 | Zinc finger protein 624; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| OR7D4 protein network | https://string-db.org/network/9606.ENSP00000310488 | Olfactory receptor 7D4; Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone; Olfactory receptors, family 7 |
| SLC16A11 protein network | https://string-db.org/network/9606.ENSP00000310490 | Monocarboxylate transporter 11; Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overex [...] |
| ARHGAP1 protein network | https://string-db.org/network/9606.ENSP00000310491 | Rho GTPase-activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate; BCH d [...] |
| PRM1 protein network | https://string-db.org/network/9606.ENSP00000310515 | Sperm protamine P1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive c [...] |
| ERCC4 protein network | https://string-db.org/network/9606.ENSP00000310520 | DNA repair endonuclease XPF; Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that [...] |
| SEC22A protein network | https://string-db.org/network/9606.ENSP00000310521 | Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex; SNAREs |
| ADCK5 protein network | https://string-db.org/network/9606.ENSP00000310547 | Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosp [...] |
| LCLAT1 protein network | https://string-db.org/network/9606.ENSP00000310551 | Lysocardiolipin acyltransferase 1; Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) a [...] |
| KCNE3 protein network | https://string-db.org/network/9606.ENSP00000310557 | Potassium voltage-gated channel subfamily E member 3; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...] |
| ARHGAP32 protein network | https://string-db.org/network/9606.ENSP00000310561 | Rho GTPase-activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during t [...] |
| DSEL protein network | https://string-db.org/network/9606.ENSP00000310565 | Dermatan-sulfate epimerase-like protein; Dermatan sulfate epimerase like; Belongs to the dermatan-sulfate isomerase family |
| PSMC5 protein network | https://string-db.org/network/9606.ENSP00000310572 | 26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| KRT25 protein network | https://string-db.org/network/9606.ENSP00000310573 | Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) ( [...] |
| PCP2 protein network | https://string-db.org/network/9606.ENSP00000310585 | Purkinje cell protein 2 homolog; May function as a cell-type specific modulator for G protein-mediated cell signaling |
| MAP9 protein network | https://string-db.org/network/9606.ENSP00000310593 | Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing inter [...] |
| FNDC9 protein network | https://string-db.org/network/9606.ENSP00000310594 | Fibronectin type III domain containing 9 |
| LSM1 protein network | https://string-db.org/network/9606.ENSP00000310596 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits- containin [...] |
| SNX32 protein network | https://string-db.org/network/9606.ENSP00000310620 | Sorting nexin-32; May be involved in several stages of intracellular trafficking; PX-BAR domain containing |
| APOBEC4 protein network | https://string-db.org/network/9606.ENSP00000310622 | Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known; Apolipoprotein B mRNA editing enzyme catalytic subunits |
| ISCU protein network | https://string-db.org/network/9606.ENSP00000310623 | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron- sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both m [...] |
| MRGPRD protein network | https://string-db.org/network/9606.ENSP00000310631 | Mas-related G-protein coupled receptor member D; May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for [...] |
| OR8S1 protein network | https://string-db.org/network/9606.ENSP00000310632 | Olfactory receptor 8S1; Odorant receptor; Olfactory receptors, family 8 |
| BRSK1 protein network | https://string-db.org/network/9606.ENSP00000310649 | Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, [...] |
| NDST2 protein network | https://string-db.org/network/9606.ENSP00000310657 | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosam [...] |
| PDE7B protein network | https://string-db.org/network/9606.ENSP00000310661 | cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-m [...] |
| NUP93 protein network | https://string-db.org/network/9606.ENSP00000310668 | Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal developme [...] |
| CCAR2 protein network | https://string-db.org/network/9606.ENSP00000310670 | Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and [...] |
| FBXW8 protein network | https://string-db.org/network/9606.ENSP00000310686 | F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of [...] |
| ABCD2 protein network | https://string-db.org/network/9606.ENSP00000310688 | ATP-binding cassette sub-family D member 2; Probable transporter; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily |
| B4GALT2 protein network | https://string-db.org/network/9606.ENSP00000310696 | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce la [...] |
| OR10H5 protein network | https://string-db.org/network/9606.ENSP00000310704 | Olfactory receptor 10H5; Odorant receptor; Olfactory receptors, family 10 |
| CYP7B1 protein network | https://string-db.org/network/9606.ENSP00000310721 | 25-hydroxycholesterol 7-alpha-hydroxylase; Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25- hydroxycholesterol. Plays a key role i [...] |
| MOS protein network | https://string-db.org/network/9606.ENSP00000310722 | Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| DDX23 protein network | https://string-db.org/network/9606.ENSP00000310723 | Probable ATP-dependent RNA helicase DDX23; Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation; DEAD-box helicases |
| MRPL57 protein network | https://string-db.org/network/9606.ENSP00000310726 | Mitochondrial ribosomal protein L57; Belongs to the mitochondrion-specific ribosomal protein mL63 family |
| GLIPR1L1 protein network | https://string-db.org/network/9606.ENSP00000310770 | GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins [...] |
| OR1L1 protein network | https://string-db.org/network/9606.ENSP00000310773 | Olfactory receptor 1L1; Odorant receptor; Olfactory receptors, family 1 |
| OR5J2 protein network | https://string-db.org/network/9606.ENSP00000310788 | Olfactory receptor 5J2; Odorant receptor; Olfactory receptors, family 5 |
| THAP2 protein network | https://string-db.org/network/9606.ENSP00000310796 | THAP domain containing 2 |
| LKAAEAR1 protein network | https://string-db.org/network/9606.ENSP00000310801 | Protein LKAAEAR1; LKAAEAR motif containing 1 |
| SFT2D3 protein network | https://string-db.org/network/9606.ENSP00000310803 | Vesicle transport protein SFT2C; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex |
| TTC18 protein network | https://string-db.org/network/9606.ENSP00000310829 | Cilia- and flagella-associated protein 70; Tetratricopeptide repeat domain 18; Belongs to the CFAP70 family |
| CTSF protein network | https://string-db.org/network/9606.ENSP00000310832 | Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins |
| FBXO31 protein network | https://string-db.org/network/9606.ENSP00000310841 | F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin- [...] |
| FANCI protein network | https://string-db.org/network/9606.ENSP00000310842 | Fanconi anemia group I protein; Plays an essential role in the repair of DNA double- strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting [...] |
| VN1R4 protein network | https://string-db.org/network/9606.ENSP00000310856 | Vomeronasal type-1 receptor 4; Putative pheromone receptor; Belongs to the G-protein coupled receptor 1 family |
| KRT2 protein network | https://string-db.org/network/9606.ENSP00000310861 | Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II |
| COQ2 protein network | https://string-db.org/network/9606.ENSP00000310873 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction [...] |
| MAL protein network | https://string-db.org/network/9606.ENSP00000310880 | Myelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis an [...] |
| CSRP2 protein network | https://string-db.org/network/9606.ENSP00000310901 | Cysteine and glycine-rich protein 2; Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in [...] |
| PPARD protein network | https://string-db.org/network/9606.ENSP00000310928 | Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference [...] |
| MADD protein network | https://string-db.org/network/9606.ENSP00000310933 | MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell prolife [...] |
| PHYKPL protein network | https://string-db.org/network/9606.ENSP00000310978 | 5-phosphohydroxy-L-lysine phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semia [...] |
| NAGPA protein network | https://string-db.org/network/9606.ENSP00000310998 | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by [...] |
| MAPK7 protein network | https://string-db.org/network/9606.ENSP00000311005 | Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. [...] |
| ELF5 protein network | https://string-db.org/network/9606.ENSP00000311010 | ETS-related transcription factor Elf-5; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation; Belongs to the ETS family |
| ABCC12 protein network | https://string-db.org/network/9606.ENSP00000311030 | Multidrug resistance-associated protein 9; Probable transporter; ATP binding cassette subfamily C |
| CASP3 protein network | https://string-db.org/network/9606.ENSP00000311032 | Caspase-3; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-As [...] |
| CD200R1 protein network | https://string-db.org/network/9606.ENSP00000311035 | Cell surface glycoprotein CD200 receptor 1; Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules includin [...] |
| OR6M1 protein network | https://string-db.org/network/9606.ENSP00000311038 | Olfactory receptor 6M1; Odorant receptor; Olfactory receptors, family 6 |
| CKS1B protein network | https://string-db.org/network/9606.ENSP00000311083 | Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function |
| CYP4A11 protein network | https://string-db.org/network/9606.ENSP00000311095 | Cytochrome P450 4A11; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidiz [...] |
| PSMA8 protein network | https://string-db.org/network/9606.ENSP00000311121 | Proteasome subunit alpha type-7-like; Component of the spermatoproteasome, a form of the proteasome specifically found in testis that promotes degradation of histones, thereby participating activ [...] |
| TMEM52 protein network | https://string-db.org/network/9606.ENSP00000311122 | Transmembrane protein 52 |
| VEGFB protein network | https://string-db.org/network/9606.ENSP00000311127 | Vascular endothelial growth factor B; Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis |
| DHX37 protein network | https://string-db.org/network/9606.ENSP00000311135 | Probable ATP-dependent RNA helicase DHX37; DEAH-box helicase 37 |
| AQP1 protein network | https://string-db.org/network/9606.ENSP00000311165 | Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the di [...] |
| ZNF497 protein network | https://string-db.org/network/9606.ENSP00000311183 | Zinc finger protein 497; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| WFIKKN2 protein network | https://string-db.org/network/9606.ENSP00000311184 | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metallopro [...] |
| NPAS4 protein network | https://string-db.org/network/9606.ENSP00000311196 | Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contex [...] |
| C1orf100 protein network | https://string-db.org/network/9606.ENSP00000311218 | Uncharacterized protein C1orf100; Chromosome 1 open reading frame 100 |
| TRIM59 protein network | https://string-db.org/network/9606.ENSP00000311219 | Tripartite motif-containing protein 59; May serve as a multifunctional regulator for innate immune signaling pathways; Ring finger proteins |
| ZMAT3 protein network | https://string-db.org/network/9606.ENSP00000311221 | Zinc finger matrin-type protein 3; Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regul [...] |
| ACOT1 protein network | https://string-db.org/network/9606.ENSP00000311224 | Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to r [...] |
| STOX2 protein network | https://string-db.org/network/9606.ENSP00000311257 | Storkhead-box protein 2; Storkhead box 2 |
| DNAH7 protein network | https://string-db.org/network/9606.ENSP00000311273 | Dynein heavy chain 7, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| ELF4 protein network | https://string-db.org/network/9606.ENSP00000311280 | ETS-related transcription factor Elf-4; Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor gene [...] |
| PROP1 protein network | https://string-db.org/network/9606.ENSP00000311290 | Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes; PRD class homeoboxes and pseud [...] |
| SLCO2A1 protein network | https://string-db.org/network/9606.ENSP00000311291 | Solute carrier organic anion transporter family member 2A1; May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the cleara [...] |
| CTSW protein network | https://string-db.org/network/9606.ENSP00000311300 | Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Cathepsins |
| CST6 protein network | https://string-db.org/network/9606.ENSP00000311313 | Cystatin-M; Shows moderate inhibition of cathepsin B but is not active against cathepsin C; Belongs to the cystatin family |
| ATG4D protein network | https://string-db.org/network/9606.ENSP00000311318 | Cysteine protease ATG4D; Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins [...] |
| ZNF417 protein network | https://string-db.org/network/9606.ENSP00000311319 | Zinc finger protein 417; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ATP8B3 protein network | https://string-db.org/network/9606.ENSP00000311336 | Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membran [...] |
| WDR49 protein network | https://string-db.org/network/9606.ENSP00000311343 | WD repeat-containing protein 49; WD repeat domain containing |
| PPP2R1B protein network | https://string-db.org/network/9606.ENSP00000311344 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the cat [...] |
| RAD9A protein network | https://string-db.org/network/9606.ENSP00000311360 | Cell cycle checkpoint control protein RAD9A; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon [...] |
| MUCL1 protein network | https://string-db.org/network/9606.ENSP00000311364 | Mucin-like protein 1; May play a role as marker for the diagnosis of metastatic breast cancer |
| POLD4 protein network | https://string-db.org/network/9606.ENSP00000311368 | DNA polymerase delta subunit 4; As a component of the tetrameric DNA polymerase delta complex (Pol-delta4), plays a role in high fidelity genome replication and repair. Within this complex, incre [...] |
| RNASE8 protein network | https://string-db.org/network/9606.ENSP00000311398 | Ribonuclease 8; Has a low ribonuclease activity |
| DSCR3 protein network | https://string-db.org/network/9606.ENSP00000311399 | Down syndrome critical region gene 3; Belongs to the VPS26 family |
| DENND6A protein network | https://string-db.org/network/9606.ENSP00000311401 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 [...] |
| ADCY6 protein network | https://string-db.org/network/9606.ENSP00000311405 | Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors [...] |
| SNX33 protein network | https://string-db.org/network/9606.ENSP00000311427 | Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during i [...] |
| ZWILCH protein network | https://string-db.org/network/9606.ENSP00000311429 | Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 comple [...] |
| RPL4 protein network | https://string-db.org/network/9606.ENSP00000311430 | L ribosomal proteins |
| ABRA protein network | https://string-db.org/network/9606.ENSP00000311436 | Actin-binding Rho-activating protein; Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechani [...] |
| ASPHD1 protein network | https://string-db.org/network/9606.ENSP00000311447 | Aspartate beta-hydroxylase domain containing 1 |
| RAB6A protein network | https://string-db.org/network/9606.ENSP00000311449 | Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independe [...] |
| PDE8A protein network | https://string-db.org/network/9606.ENSP00000311453 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May b [...] |
| GSTM1 protein network | https://string-db.org/network/9606.ENSP00000311469 | Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Soluble glutathione S-transferases |
| OR10AG1 protein network | https://string-db.org/network/9606.ENSP00000311477 | Olfactory receptor 10AG1; Odorant receptor; Olfactory receptors, family 10 |
| C11orf86 protein network | https://string-db.org/network/9606.ENSP00000311479 | Uncharacterized protein C11orf86; Chromosome 11 open reading frame 86 |
| C12orf66 protein network | https://string-db.org/network/9606.ENSP00000311486 | KICSTOR complex protein C12orf66; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATO [...] |
| ISX protein network | https://string-db.org/network/9606.ENSP00000311492 | Intestine-specific homeobox; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine ( [...] |
| MZT2A protein network | https://string-db.org/network/9606.ENSP00000311500 | Mitotic spindle organizing protein 2A; Belongs to the MOZART2 family |
| HEG1 protein network | https://string-db.org/network/9606.ENSP00000311502 | Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity May act through the stabilization of endothelial ce [...] |
| IQCB1 protein network | https://string-db.org/network/9606.ENSP00000311505 | IQ calmodulin-binding motif-containing protein 1; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6. Involved in regulation o [...] |
| RSF1 protein network | https://string-db.org/network/9606.ENSP00000311513 | Remodeling and spacing factor 1; Required for assembly of regular nucleosome arrays by the RSF chromatin-remodeling complex. Facilitates transcription of hepatitis B virus (HBV) genes by the pX t [...] |
| ZNF490 protein network | https://string-db.org/network/9606.ENSP00000311521 | Zinc finger protein 490; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GPR162 protein network | https://string-db.org/network/9606.ENSP00000311528 | Probable G-protein coupled receptor 162; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ARR3 protein network | https://string-db.org/network/9606.ENSP00000311538 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins; Classical arrestins |
| EMR1 protein network | https://string-db.org/network/9606.ENSP00000311545 | Adhesion G protein-coupled receptor E1; Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regu [...] |
| TNKS protein network | https://string-db.org/network/9606.ENSP00000311579 | Tankyrase-1; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by [...] |
| OR4B1 protein network | https://string-db.org/network/9606.ENSP00000311605 | Olfactory receptor 4B1; Odorant receptor; Olfactory receptors, family 4 |
| SPSB4 protein network | https://string-db.org/network/9606.ENSP00000311609 | SPRY domain-containing SOCS box protein 4; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the u [...] |
| UGT8 protein network | https://string-db.org/network/9606.ENSP00000311648 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingo [...] |
| GRAMD2 protein network | https://string-db.org/network/9606.ENSP00000311657 | GRAM domain-containing protein 2A; GRAM domain containing 2 |
| PAAF1 protein network | https://string-db.org/network/9606.ENSP00000311665 | Proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 in [...] |
| PPP1R8 protein network | https://string-db.org/network/9606.ENSP00000311677 | Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-ass [...] |
| ZNF483 protein network | https://string-db.org/network/9606.ENSP00000311679 | Zinc finger protein 483; May be involved in transcriptional regulation; SCAN domain containing |
| SPEG protein network | https://string-db.org/network/9606.ENSP00000311684 | Striated muscle preferentially expressed protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells; I-set domain containing |
| NIPAL4 protein network | https://string-db.org/network/9606.ENSP00000311687 | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity [...] |
| OR1S1 protein network | https://string-db.org/network/9606.ENSP00000311688 | Olfactory receptor 1S1; Odorant receptor; Olfactory receptors, family 1 |
| CCDC85B protein network | https://string-db.org/network/9606.ENSP00000311695 | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53- dependent manner and thus regulate cell growth. May function in [...] |
| FGF5 protein network | https://string-db.org/network/9606.ENSP00000311697 | Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhi [...] |
| RTP1 protein network | https://string-db.org/network/9606.ENSP00000311712 | Receptor-transporting protein 1; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs; Belongs to the TMEM7 family |
| OXSR1 protein network | https://string-db.org/network/9606.ENSP00000311713 | Serine/threonine-protein kinase OSR1; Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton; Belongs to the protein kinas [...] |
| CMKLR1 protein network | https://string-db.org/network/9606.ENSP00000311733 | Chemokine-like receptor 1; Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of [...] |
| KLK10 protein network | https://string-db.org/network/9606.ENSP00000311746 | Kallikrein-10; Has a tumor-suppressor role for NES1 in breast and prostate cancer; Belongs to the peptidase S1 family. Kallikrein subfamily |
| RBM14 protein network | https://string-db.org/network/9606.ENSP00000311747 | RNA-binding protein 14; Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcript [...] |
| TTC9B protein network | https://string-db.org/network/9606.ENSP00000311760 | Belongs to the TTC9 family |
| ATAD3B protein network | https://string-db.org/network/9606.ENSP00000311766 | ATPase family AAA domain-containing protein 3B; May play a role in a mitochondrial network organization typical for stem cells, characterized by reduced mitochondrial metabolism, low mtDNA copies [...] |
| ZMIZ2 protein network | https://string-db.org/network/9606.ENSP00000311778 | Zinc finger MIZ domain-containing protein 2; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors; Zinc fingers MIZ-type |
| REST protein network | https://string-db.org/network/9606.ENSP00000311816 | RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the [...] |
| CTBP2 protein network | https://string-db.org/network/9606.ENSP00000311825 | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity) |
| MSL2 protein network | https://string-db.org/network/9606.ENSP00000311827 | E3 ubiquitin-protein ligase MSL2; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher [...] |
| SLC37A2 protein network | https://string-db.org/network/9606.ENSP00000311833 | Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and transl [...] |
| SNTG2 protein network | https://string-db.org/network/9606.ENSP00000311837 | Gamma-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystro [...] |
| PTPN2 protein network | https://string-db.org/network/9606.ENSP00000311857 | Tyrosine-protein phosphatase non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also [...] |
| MS4A10 protein network | https://string-db.org/network/9606.ENSP00000311862 | Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| DAW1 protein network | https://string-db.org/network/9606.ENSP00000311899 | Dynein assembly factor with WDR repeat domains 1; May play a role in axonemal outer row dynein assembly; Belongs to the WD repeat WDR69 family |
| LTBP4 protein network | https://string-db.org/network/9606.ENSP00000311905 | Latent-transforming growth factor beta-binding protein 4; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical role [...] |
| ZNF738 protein network | https://string-db.org/network/9606.ENSP00000311957 | Protein ZNF738; May be involved in transcriptional regulation |
| GGA2 protein network | https://string-db.org/network/9606.ENSP00000311962 | ADP-ribosylation factor-binding protein GGA2; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clath [...] |
| DUS3L protein network | https://string-db.org/network/9606.ENSP00000311977 | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs |
| CARKD protein network | https://string-db.org/network/9606.ENSP00000311984 | ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which cataly [...] |
| NEFH protein network | https://string-db.org/network/9606.ENSP00000311997 | Neurofilament heavy polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important [...] |
| HAVCR2 protein network | https://string-db.org/network/9606.ENSP00000312002 | Hepatitis A virus cellular receptor 2; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulati [...] |
| FAM57A protein network | https://string-db.org/network/9606.ENSP00000312017 | Protein FAM57A; Family with sequence similarity 57 member A; TLC domain containing |
| FUT1 protein network | https://string-db.org/network/9606.ENSP00000312021 | Galactoside 2-alpha-L-fucosyltransferase 1; Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the s [...] |
| CD7 protein network | https://string-db.org/network/9606.ENSP00000312027 | T-cell antigen CD7; Not yet known; CD molecules |
| UCP2 protein network | https://string-db.org/network/9606.ENSP00000312029 | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP [...] |
| SRP68 protein network | https://string-db.org/network/9606.ENSP00000312066 | Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S [...] |
| PCDHGC3 protein network | https://string-db.org/network/9606.ENSP00000312070 | Protocadherin gamma-C3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| SSH3 protein network | https://string-db.org/network/9606.ENSP00000312081 | Protein phosphatase Slingshot homolog 3; Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing [...] |
| TLR8 protein network | https://string-db.org/network/9606.ENSP00000312082 | Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific t [...] |
| UBXN2A protein network | https://string-db.org/network/9606.ENSP00000312107 | UBX domain-containing protein 2A; UBX domain containing |
| ADCY4 protein network | https://string-db.org/network/9606.ENSP00000312126 | Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling; Adenylate cyclases |
| KCNG4 protein network | https://string-db.org/network/9606.ENSP00000312129 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...] |
| PRG2 protein network | https://string-db.org/network/9606.ENSP00000312134 | Bone marrow proteoglycan; Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity [...] |
| ZNF654 protein network | https://string-db.org/network/9606.ENSP00000312141 | Zinc finger protein 654; May be involved in transcriptional regulation |
| TNS3 protein network | https://string-db.org/network/9606.ENSP00000312143 | Tensin-3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of I [...] |
| TRIB1 protein network | https://string-db.org/network/9606.ENSP00000312150 | Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with RFWD2/COP1 ubiquitin ligase. The RFWD2-binding motif is masked by autoinhibitory interactions with the prot [...] |
| BTN2A1 protein network | https://string-db.org/network/9606.ENSP00000312158 | Butyrophilin subfamily 2 member A1; Butyrophilins |
| ELMO1 protein network | https://string-db.org/network/9606.ENSP00000312185 | Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...] |
| OR5M3 protein network | https://string-db.org/network/9606.ENSP00000312208 | Olfactory receptor 5M3; Odorant receptor; Olfactory receptors, family 5 |
| ZHX3 protein network | https://string-db.org/network/9606.ENSP00000312222 | Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene [...] |
| DTD2 protein network | https://string-db.org/network/9606.ENSP00000312224 | Putative D-tyrosyl-tRNA(Tyr) deacylase 2; May D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (Potential) |
| MSL3 protein network | https://string-db.org/network/9606.ENSP00000312244 | Male-specific lethal 3 homolog; May be involved in chromatin remodeling and transcriptional regulation. May have a role in X inactivation. Component of the MSL complex which is responsible for th [...] |
| ADPGK protein network | https://string-db.org/network/9606.ENSP00000312250 | ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By simil [...] |
| ADRBK1 protein network | https://string-db.org/network/9606.ENSP00000312262 | Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key reg [...] |
| YPEL2 protein network | https://string-db.org/network/9606.ENSP00000312272 | Protein yippee-like 2; Yippee like family |
| LGI4 protein network | https://string-db.org/network/9606.ENSP00000312273 | Leucine rich repeat LGI family member 4 |
| ZNF507 protein network | https://string-db.org/network/9606.ENSP00000312277 | Zinc finger protein 507; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SPESP1 protein network | https://string-db.org/network/9606.ENSP00000312284 | Sperm equatorial segment protein 1; Involved in fertilization ability of sperm; Belongs to the SPESP1 family |
| PLA2G1B protein network | https://string-db.org/network/9606.ENSP00000312286 | Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precurs [...] |
| MOBP protein network | https://string-db.org/network/9606.ENSP00000312293 | Myelin-associated oligodendrocyte basic protein |
| FRG2C protein network | https://string-db.org/network/9606.ENSP00000312299 | Protein FRG2-like-2; FSHD region gene 2 family member C |
| TPMT protein network | https://string-db.org/network/9606.ENSP00000312304 | Thiopurine S-methyltransferase; Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family |
| MRPL46 protein network | https://string-db.org/network/9606.ENSP00000312311 | Mitochondrial ribosomal protein L46; Belongs to the mitochondrion-specific ribosomal protein mL46 family |
| SSSCA1 protein network | https://string-db.org/network/9606.ENSP00000312318 | Sjoegren syndrome/scleroderma autoantigen 1; Might play a role in mitosis. Antigenic molecule. Could be a centromere-associated protein. May induce anti-centromere antibodies |
| AOC3 protein network | https://string-db.org/network/9606.ENSP00000312326 | Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular end [...] |
| TRMT10C protein network | https://string-db.org/network/9606.ENSP00000312356 | tRNA methyltransferase 10 homolog C; Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/ [...] |
| CD84 protein network | https://string-db.org/network/9606.ENSP00000312367 | SLAM family member 5; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...] |
| SNX31 protein network | https://string-db.org/network/9606.ENSP00000312368 | Sorting nexin-31; May be involved in protein trafficking; Sorting nexins |
| KMT2E protein network | https://string-db.org/network/9606.ENSP00000312379 | Histone-lysine N-methyltransferase 2E; Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specifi [...] |
| EVX2 protein network | https://string-db.org/network/9606.ENSP00000312385 | Homeobox even-skipped homolog protein 2; HOXL subclass homeoboxes; Belongs to the even-skipped homeobox family |
| KLHL3 protein network | https://string-db.org/network/9606.ENSP00000312397 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts [...] |
| CCDC63 protein network | https://string-db.org/network/9606.ENSP00000312399 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads |
| OR2Y1 protein network | https://string-db.org/network/9606.ENSP00000312403 | Olfactory receptor 2Y1; Odorant receptor; Olfactory receptors, family 2 |
| PPM1E protein network | https://string-db.org/network/9606.ENSP00000312411 | Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhi [...] |
| SSX5 protein network | https://string-db.org/network/9606.ENSP00000312415 | Synovial sarcoma, X breakpoint 5; SSX family member 5 |
| RNF26 protein network | https://string-db.org/network/9606.ENSP00000312439 | E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear po [...] |
| AP1G2 protein network | https://string-db.org/network/9606.ENSP00000312442 | AP-1 complex subunit gamma-like 2; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV); Clathrin/coat [...] |
| CFLAR protein network | https://string-db.org/network/9606.ENSP00000312455 | CASP8 and FADD-like apoptosis regulator; Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of [...] |
| BAALC protein network | https://string-db.org/network/9606.ENSP00000312457 | Brain and acute leukemia, cytoplasmic; BAALC, MAP3K1 and KLF4 binding |
| ARV1 protein network | https://string-db.org/network/9606.ENSP00000312458 | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membr [...] |
| OR10A6 protein network | https://string-db.org/network/9606.ENSP00000312470 | Olfactory receptor 10A6; Odorant receptor; Olfactory receptors, family 10 |
| CSPG4 protein network | https://string-db.org/network/9606.ENSP00000312506 | Chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibi [...] |
| LRFN4 protein network | https://string-db.org/network/9606.ENSP00000312535 | Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By simil [...] |
| DNAH12 protein network | https://string-db.org/network/9606.ENSP00000312554 | Dynein axonemal heavy chain 12 |
| COQ10A protein network | https://string-db.org/network/9606.ENSP00000312587 | Coenzyme Q-binding protein COQ10 homolog A, mitochondrial; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 fro [...] |
| TMEM70 protein network | https://string-db.org/network/9606.ENSP00000312599 | Transmembrane protein 70, mitochondrial; Involved in biogenesis of mitochondrial ATP synthase; Belongs to the TMEM70 family |
| TMEM134 protein network | https://string-db.org/network/9606.ENSP00000312615 | Transmembrane protein 134 |
| ACAD9 protein network | https://string-db.org/network/9606.ENSP00000312618 | Acyl-CoA dehydrogenase family member 9, mitochondrial; Required for mitochondrial complex I assembly. Has a dehydrogenase activity on palmitoyl-CoA (C16:0) and stearoyl-CoA (C18:0). It is three t [...] |
| TCAP protein network | https://string-db.org/network/9606.ENSP00000312624 | Telethonin; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk |
| HP1BP3 protein network | https://string-db.org/network/9606.ENSP00000312625 | Heterochromatin protein 1-binding protein 3; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically inf [...] |
| INSM1 protein network | https://string-db.org/network/9606.ENSP00000312631 | Insulinoma-associated protein 1; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or feta [...] |
| PDLIM2 protein network | https://string-db.org/network/9606.ENSP00000312634 | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression en [...] |
| PPARGC1B protein network | https://string-db.org/network/9606.ENSP00000312649 | Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of es [...] |
| LEP protein network | https://string-db.org/network/9606.ENSP00000312652 | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, whic [...] |
| CHRNA9 protein network | https://string-db.org/network/9606.ENSP00000312663 | Neuronal acetylcholine receptor subunit alpha-9; Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding induces a conformation change that leads to the op [...] |
| CASP2 protein network | https://string-db.org/network/9606.ENSP00000312664 | Caspase-2; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins n [...] |
| EHBP1L1 protein network | https://string-db.org/network/9606.ENSP00000312671 | EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking; NT-C2 domain containing |
| TMEM136 protein network | https://string-db.org/network/9606.ENSP00000312672 | Transmembrane protein 136; Belongs to the TMEM136 family |
| GH1 protein network | https://string-db.org/network/9606.ENSP00000312673 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentia [...] |
| TRIM72 protein network | https://string-db.org/network/9606.ENSP00000312675 | Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically [...] |
| MID1 protein network | https://string-db.org/network/9606.ENSP00000312678 | E3 ubiquitin-protein ligase Midline-1; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphat [...] |
| B3GNT8 protein network | https://string-db.org/network/9606.ENSP00000312700 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N-glyca [...] |
| DEFB114 protein network | https://string-db.org/network/9606.ENSP00000312702 | Beta-defensin 114; Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and n [...] |
| CCDC65 protein network | https://string-db.org/network/9606.ENSP00000312706 | Coiled-coil domain-containing protein 65; May play a role in motile cilia function, possibly by acting on the assembly of the nexin-dynein regulatory complex; Belongs to the CCDC65 family |
| TAF7 protein network | https://string-db.org/network/9606.ENSP00000312709 | Transcription initiation factor TFIID subunit 7; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in [...] |
| RAB8B protein network | https://string-db.org/network/9606.ENSP00000312734 | Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| CAMKK2 protein network | https://string-db.org/network/9606.ENSP00000312741 | Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular proc [...] |
| FAM109B protein network | https://string-db.org/network/9606.ENSP00000312753 | Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Belongs to the sesquipedalian fam [...] |
| KIAA1731NL protein network | https://string-db.org/network/9606.ENSP00000312767 | CEP295 N-terminal-like protein; KIAA1731 N-terminal like |
| C2orf69 protein network | https://string-db.org/network/9606.ENSP00000312770 | UPF0565 protein C2orf69; Chromosome 2 open reading frame 69 |
| SPACA4 protein network | https://string-db.org/network/9606.ENSP00000312774 | Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization; LY6/PLAUR domain containin [...] |
| IFT80 protein network | https://string-db.org/network/9606.ENSP00000312778 | Intraflagellar transport protein 80 homolog; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia |
| KCNK10 protein network | https://string-db.org/network/9606.ENSP00000312811 | Potassium channel subfamily K member 10; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and [...] |
| KCTD2 protein network | https://string-db.org/network/9606.ENSP00000312814 | BTB/POZ domain-containing protein KCTD2; Potassium channel tetramerization domain containing 2 |
| MLXIP protein network | https://string-db.org/network/9606.ENSP00000312834 | MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycoly [...] |
| SEZ6 protein network | https://string-db.org/network/9606.ENSP00000312942 | Seizure protein 6 homolog; May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongat [...] |
| STAB1 protein network | https://string-db.org/network/9606.ENSP00000312946 | Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. [...] |
| USP39 protein network | https://string-db.org/network/9606.ENSP00000312981 | U4/U6.U5 tri-snRNP-associated protein 2; Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. Regulates AURKB mRNA levels, an [...] |
| HNF4A protein network | https://string-db.org/network/9606.ENSP00000312987 | Hepatocyte nuclear factor 4-alpha; Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1- antitrypsin, apolipoprotein CIII, transthyretin [...] |
| NFKBIB protein network | https://string-db.org/network/9606.ENSP00000312988 | NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kapp [...] |
| CLSPN protein network | https://string-db.org/network/9606.ENSP00000312995 | Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds [...] |
| GNAI2 protein network | https://string-db.org/network/9606.ENSP00000312999 | Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The [...] |
| PABPC1 protein network | https://string-db.org/network/9606.ENSP00000313007 | Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA spli [...] |
| FBXW5 protein network | https://string-db.org/network/9606.ENSP00000313034 | F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition [...] |
| GBAS protein network | https://string-db.org/network/9606.ENSP00000313050 | Protein NipSnap homolog 2; May act as a positive regulator of L-type calcium channels; Belongs to the NipSnap family |
| SHISA2 protein network | https://string-db.org/network/9606.ENSP00000313079 | Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling; Shisa family members |
| NETO1 protein network | https://string-db.org/network/9606.ENSP00000313088 | Neuropilin and tolloid-like protein 1; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for [...] |
| OR6S1 protein network | https://string-db.org/network/9606.ENSP00000313110 | Olfactory receptor 6S1; Odorant receptor; Olfactory receptors, family 6 |
| SNX14 protein network | https://string-db.org/network/9606.ENSP00000313121 | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking (By similarity). Required for [...] |
| EXD2 protein network | https://string-db.org/network/9606.ENSP00000313140 | Exonuclease 3'-5' domain-containing protein 2; Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of [...] |
| ZNF366 protein network | https://string-db.org/network/9606.ENSP00000313158 | Zinc finger protein 366; Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases; Zinc fingers C2H2-type |
| FBXO34 protein network | https://string-db.org/network/9606.ENSP00000313159 | F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| NPHP1 protein network | https://string-db.org/network/9606.ENSP00000313169 | Nephrocystin-1; Together with BCAR1 it may play a role in the control of epithelial cell polarity. Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1 [...] |
| ATAD5 protein network | https://string-db.org/network/9606.ENSP00000313171 | ATPase family AAA domain-containing protein 5; Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is co [...] |
| BVES protein network | https://string-db.org/network/9606.ENSP00000313172 | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) p [...] |
| HNRNPD protein network | https://string-db.org/network/9606.ENSP00000313199 | Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto- oncogenes and cytokine mRNAs. Als [...] |
| CTXN1 protein network | https://string-db.org/network/9606.ENSP00000313226 | Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development |
| HSF5 protein network | https://string-db.org/network/9606.ENSP00000313243 | Heat shock factor protein 5; May act as a transcriptional factor |
| FUZ protein network | https://string-db.org/network/9606.ENSP00000313309 | Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of t [...] |
| SLC35C1 protein network | https://string-db.org/network/9606.ENSP00000313318 | GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily |
| RNASEH1 protein network | https://string-db.org/network/9606.ENSP00000313350 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA- DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid form [...] |
| PANK2 protein network | https://string-db.org/network/9606.ENSP00000313377 | Pantothenate kinase 2, mitochondrial; May be the master regulator of the CoA biosynthesis; Belongs to the type II pantothenate kinase family |
| OR1E1 protein network | https://string-db.org/network/9606.ENSP00000313384 | Olfactory receptor 1E1; Odorant receptor; Olfactory receptors, family 1 |
| DAB2 protein network | https://string-db.org/network/9606.ENSP00000313391 | Disabled homolog 2; Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clat [...] |
| FUT6 protein network | https://string-db.org/network/9606.ENSP00000313398 | Alpha-(1,3)-fucosyltransferase 6; Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP- beta-fucose to alpha-2,3 sialylated subs [...] |
| PRKDC protein network | https://string-db.org/network/9606.ENSP00000313420 | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for doub [...] |
| ARL6IP4 protein network | https://string-db.org/network/9606.ENSP00000313422 | ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. I [...] |
| GFRA4 protein network | https://string-db.org/network/9606.ENSP00000313423 | GDNF family receptor alpha-4; Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnata [...] |
| GRHPR protein network | https://string-db.org/network/9606.ENSP00000313432 | Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glyce [...] |
| MMP19 protein network | https://string-db.org/network/9606.ENSP00000313437 | Matrix metalloproteinase-19; Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemo [...] |
| ZNF491 protein network | https://string-db.org/network/9606.ENSP00000313443 | Zinc finger protein 491; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| UBA6 protein network | https://string-db.org/network/9606.ENSP00000313454 | Ubiquitin-like modifier-activating enzyme 6; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine [...] |
| PFAS protein network | https://string-db.org/network/9606.ENSP00000313490 | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ri [...] |
| C17orf53 protein network | https://string-db.org/network/9606.ENSP00000313500 | Uncharacterized protein C17orf53; Chromosome 17 open reading frame 53 |
| PHKB protein network | https://string-db.org/network/9606.ENSP00000313504 | Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory uni [...] |
| LGALS7B protein network | https://string-db.org/network/9606.ENSP00000313571 | Lectin, galactoside-binding, soluble, 7B; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly [...] |
| KLK2 protein network | https://string-db.org/network/9606.ENSP00000313581 | Kallikrein-2; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin |
| ZNF436 protein network | https://string-db.org/network/9606.ENSP00000313582 | Zinc finger protein 436; May be a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ATP10B protein network | https://string-db.org/network/9606.ENSP00000313600 | Probable phospholipid-transporting ATPase VB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...] |
| CC2D1A protein network | https://string-db.org/network/9606.ENSP00000313601 | Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The com [...] |
| ABCF1 protein network | https://string-db.org/network/9606.ENSP00000313603 | ATP-binding cassette sub-family F member 1; Isoform 2 is required for efficient Cap- and IRES- mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis; ATP bind [...] |
| ALS2CL protein network | https://string-db.org/network/9606.ENSP00000313670 | ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics; VPS9 domain containing |
| SPHK1 protein network | https://string-db.org/network/9606.ENSP00000313681 | Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro- sp [...] |
| FTMT protein network | https://string-db.org/network/9606.ENSP00000313691 | Ferritin, mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited [...] |
| HEPHL1 protein network | https://string-db.org/network/9606.ENSP00000313699 | Hephaestin-like protein 1; May function as a ferroxidase and may be involved in copper transport and homeostasis |
| SSNA1 protein network | https://string-db.org/network/9606.ENSP00000313752 | SS nuclear autoantigen 1 |
| ASB3 protein network | https://string-db.org/network/9606.ENSP00000313756 | annotation not available |
| CTC1 protein network | https://string-db.org/network/9606.ENSP00000313759 | CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...] |
| OR3A1 protein network | https://string-db.org/network/9606.ENSP00000313803 | Olfactory receptor 3A1; Odorant receptor; Olfactory receptors, family 3 |
| AMBN protein network | https://string-db.org/network/9606.ENSP00000313809 | Ameloblastin; Involved in the mineralization and structural organization of enamel; Belongs to the ameloblastin family |
| USP20 protein network | https://string-db.org/network/9606.ENSP00000313811 | Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by m [...] |
| PRIMPOL protein network | https://string-db.org/network/9606.ENSP00000313816 | DNA-directed primase/polymerase protein; DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and [...] |
| KHDRBS1 protein network | https://string-db.org/network/9606.ENSP00000313829 | KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptor [...] |
| LCN15 protein network | https://string-db.org/network/9606.ENSP00000313833 | Lipocalin-15; Lipocalin 15; Lipocalins |
| PDS5B protein network | https://string-db.org/network/9606.ENSP00000313851 | Sister chromatid cohesion protein PDS5 homolog B; Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid coh [...] |
| CLPTM1L protein network | https://string-db.org/network/9606.ENSP00000313854 | Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed; Belongs to the CLPTM1 family |
| GORASP1 protein network | https://string-db.org/network/9606.ENSP00000313869 | Golgi reassembly-stacking protein 1; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the [...] |
| CD46 protein network | https://string-db.org/network/9606.ENSP00000313875 | Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on h [...] |
| TSFM protein network | https://string-db.org/network/9606.ENSP00000313877 | Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolys [...] |
| MKRN3 protein network | https://string-db.org/network/9606.ENSP00000313881 | Probable E3 ubiquitin-protein ligase makorin-3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Ring finger proteins |
| KIAA0195 protein network | https://string-db.org/network/9606.ENSP00000313885 | Transmembrane protein 94; KIAA0195 |
| MSRA protein network | https://string-db.org/network/9606.ENSP00000313921 | Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reducti [...] |
| OAZ3 protein network | https://string-db.org/network/9606.ENSP00000313922 | Ornithine decarboxylase antizyme 3; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...] |
| GLTSCR1L protein network | https://string-db.org/network/9606.ENSP00000313933 | BRD4-interacting chromatin-remodeling complex-associated protein-like; GLTSCR1-like |
| OR2AE1 protein network | https://string-db.org/network/9606.ENSP00000313936 | Olfactory receptor 2AE1; Odorant receptor; Olfactory receptors, family 2 |
| AURKB protein network | https://string-db.org/network/9606.ENSP00000313950 | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions a [...] |
| TTC27 protein network | https://string-db.org/network/9606.ENSP00000313953 | Tetratricopeptide repeat domain containing; Belongs to the TTC27 family |
| C1QB protein network | https://string-db.org/network/9606.ENSP00000313967 | Complement C1q subcomponent subunit B; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...] |
| WHSC1L1 protein network | https://string-db.org/network/9606.ENSP00000313983 | Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic t [...] |
| KLHDC3 protein network | https://string-db.org/network/9606.ENSP00000313995 | Kelch domain-containing protein 3; May be involved in meiotic recombination process |
| ANAPC2 protein network | https://string-db.org/network/9606.ENSP00000314004 | Anaphase-promoting complex subunit 2; Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 [...] |
| SIDT2 protein network | https://string-db.org/network/9606.ENSP00000314023 | SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported [...] |
| SENP3 protein network | https://string-db.org/network/9606.ENSP00000314029 | Sentrin-specific protease 3; Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which [...] |
| DNAJA2 protein network | https://string-db.org/network/9606.ENSP00000314030 | DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins |
| AGPAT4 protein network | https://string-db.org/network/9606.ENSP00000314036 | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone; Be [...] |
| MRGPRX4 protein network | https://string-db.org/network/9606.ENSP00000314042 | Mas-related G-protein coupled receptor member X4; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...] |
| PAK2 protein network | https://string-db.org/network/9606.ENSP00000314067 | Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle [...] |
| HIC1 protein network | https://string-db.org/network/9606.ENSP00000314080 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in devel [...] |
| CA5B protein network | https://string-db.org/network/9606.ENSP00000314099 | Carbonic anhydrase 5B, mitochondrial; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family |
| TMEM107 protein network | https://string-db.org/network/9606.ENSP00000314116 | Transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GL [...] |
| TFE3 protein network | https://string-db.org/network/9606.ENSP00000314129 | Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TF [...] |
| BOK protein network | https://string-db.org/network/9606.ENSP00000314132 | Bcl-2-related ovarian killer protein; Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways. Plays a roles as pro-apoptotic protein that positively regulate [...] |
| KLK3 protein network | https://string-db.org/network/9606.ENSP00000314151 | Prostate-specific antigen; Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum; Kallikreins |
| ZBTB33 protein network | https://string-db.org/network/9606.ENSP00000314153 | Transcriptional regulator Kaiso; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the n [...] |
| SNAP47 protein network | https://string-db.org/network/9606.ENSP00000314157 | Synaptosomal-associated protein 47; Plays a role in intracellular membrane fusion |
| SAMD12 protein network | https://string-db.org/network/9606.ENSP00000314173 | Sterile alpha motif domain containing 12 |
| WDR75 protein network | https://string-db.org/network/9606.ENSP00000314193 | WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; [...] |
| MBOAT4 protein network | https://string-db.org/network/9606.ENSP00000314196 | Ghrelin O-acyltransferase; Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid; Belongs [...] |
| VAMP2 protein network | https://string-db.org/network/9606.ENSP00000314214 | Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltag [...] |
| GPR88 protein network | https://string-db.org/network/9606.ENSP00000314223 | Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional [...] |
| CFHR1 protein network | https://string-db.org/network/9606.ENSP00000314299 | Complement factor H-related protein 1; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...] |
| OR10Q1 protein network | https://string-db.org/network/9606.ENSP00000314324 | Olfactory receptor 10Q1; Odorant receptor; Olfactory receptors, family 10 |
| MED29 protein network | https://string-db.org/network/9606.ENSP00000314343 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| DDX10 protein network | https://string-db.org/network/9606.ENSP00000314348 | Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily |
| GRINA protein network | https://string-db.org/network/9606.ENSP00000314380 | Protein lifeguard 1; Potential apoptotic regulator; Transmembrane BAX inhibitor motif containing |
| PRMT9 protein network | https://string-db.org/network/9606.ENSP00000314396 | Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically m [...] |
| CA8 protein network | https://string-db.org/network/9606.ENSP00000314407 | Carbonic anhydrase-related protein; Does not have a carbonic anhydrase catalytic activity |
| PER1 protein network | https://string-db.org/network/9606.ENSP00000314420 | Period circadian protein homolog 1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiol [...] |
| METTL1 protein network | https://string-db.org/network/9606.ENSP00000314441 | tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Methyltransferase like |
| WDR35 protein network | https://string-db.org/network/9606.ENSP00000314444 | WD repeat-containing protein 35; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimu [...] |
| UNCX protein network | https://string-db.org/network/9606.ENSP00000314480 | Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May [...] |
| GAK protein network | https://string-db.org/network/9606.ENSP00000314499 | Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Ex [...] |
| GALNT14 protein network | https://string-db.org/network/9606.ENSP00000314500 | Polypeptide N-acetylgalactosaminyltransferase 14 |
| MCM9 protein network | https://string-db.org/network/9606.ENSP00000314505 | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The M [...] |
| GBA protein network | https://string-db.org/network/9606.ENSP00000314508 | Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose . Thereby, plays a central role in the degradation of [...] |
| LYSMD3 protein network | https://string-db.org/network/9606.ENSP00000314518 | LysM and putative peptidoglycan-binding domain-containing protein 3; LysM domain containing 3 |
| MAGEB18 protein network | https://string-db.org/network/9606.ENSP00000314543 | Melanoma-associated antigen B18; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization o [...] |
| CCZ1B protein network | https://string-db.org/network/9606.ENSP00000314544 | CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated |
| UACA protein network | https://string-db.org/network/9606.ENSP00000314556 | Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulat [...] |
| MAP6D1 protein network | https://string-db.org/network/9606.ENSP00000314560 | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity; Belongs to the STOP family |
| SGSH protein network | https://string-db.org/network/9606.ENSP00000314606 | N-sulphoglucosamine sulphohydrolase; Catalyzes a step in lysosomal heparan sulfate degradation; Belongs to the sulfatase family |
| KLHL11 protein network | https://string-db.org/network/9606.ENSP00000314608 | Kelch-like protein 11; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their pr [...] |
| ARFGAP1 protein network | https://string-db.org/network/9606.ENSP00000314615 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes [...] |
| ZFAND2A protein network | https://string-db.org/network/9606.ENSP00000314619 | Zinc finger AN1-type containing 2A |
| ALDH5A1 protein network | https://string-db.org/network/9606.ENSP00000314649 | Succinate-semialdehyde dehydrogenase, mitochondrial; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); Aldehyde dehydrogenases |
| ZHX2 protein network | https://string-db.org/network/9606.ENSP00000314709 | Zinc fingers and homeoboxes protein 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA; ZF class homeoboxes and pseudogenes |
| PPFIBP1 protein network | https://string-db.org/network/9606.ENSP00000314724 | Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A; Sterile alpha motif domain containing |
| TOLLIP protein network | https://string-db.org/network/9606.ENSP00000314733 | Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits [...] |
| MBLAC2 protein network | https://string-db.org/network/9606.ENSP00000314776 | Metallo-beta-lactamase domain containing 2; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family |
| BOLL protein network | https://string-db.org/network/9606.ENSP00000314792 | Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity); Belongs [...] |
| FOXR1 protein network | https://string-db.org/network/9606.ENSP00000314806 | Forkhead box R1 |
| IL1RAP protein network | https://string-db.org/network/9606.ENSP00000314807 | Interleukin 1 receptor accessory protein; Immunoglobulin like domain containing |
| EDDM3B protein network | https://string-db.org/network/9606.ENSP00000314810 | Epididymal secretory protein E3-beta; Possible function in sperm maturation |
| ALOXE3 protein network | https://string-db.org/network/9606.ENSP00000314879 | Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compare [...] |
| ANGPT2 protein network | https://string-db.org/network/9606.ENSP00000314897 | Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence [...] |
| LRRN1 protein network | https://string-db.org/network/9606.ENSP00000314901 | Leucine rich repeat neuronal 1; I-set domain containing |
| RPRM protein network | https://string-db.org/network/9606.ENSP00000314946 | Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC [...] |
| IL20RA protein network | https://string-db.org/network/9606.ENSP00000314976 | Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26; Interleukin receptors |
| RRH protein network | https://string-db.org/network/9606.ENSP00000314992 | Visual pigment-like receptor peropsin; May play a role in rpe physiology either by detecting light directly or by monitoring the concentration of retinoids or other photoreceptor-derived compound [...] |
| SLC28A2 protein network | https://string-db.org/network/9606.ENSP00000315006 | Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selecti [...] |
| EDNRA protein network | https://string-db.org/network/9606.ENSP00000315011 | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of bindi [...] |
| CRAT protein network | https://string-db.org/network/9606.ENSP00000315013 | Carnitine O-acetyltransferase; Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be invo [...] |
| MRPL1 protein network | https://string-db.org/network/9606.ENSP00000315017 | Mitochondrial ribosomal protein L1 |
| PPP1R42 protein network | https://string-db.org/network/9606.ENSP00000315035 | Protein phosphatase 1 regulatory subunit 42; Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis |
| MAGEF1 protein network | https://string-db.org/network/9606.ENSP00000315064 | Melanoma-associated antigen F1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...] |
| GJD4 protein network | https://string-db.org/network/9606.ENSP00000315070 | Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| LSMEM2 protein network | https://string-db.org/network/9606.ENSP00000315081 | Leucine rich single-pass membrane protein 2 |
| EDDM3A protein network | https://string-db.org/network/9606.ENSP00000315098 | Epididymal secretory protein E3-alpha; Possible function in sperm maturation |
| GPR137C protein network | https://string-db.org/network/9606.ENSP00000315106 | Integral membrane protein GPR137C; G protein-coupled receptor 137C |
| RNF31 protein network | https://string-db.org/network/9606.ENSP00000315112 | E3 ubiquitin-protein ligase RNF31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in N [...] |
| ADCK4 protein network | https://string-db.org/network/9606.ENSP00000315118 | Atypical kinase COQ8B, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respi [...] |
| CLU protein network | https://string-db.org/network/9606.ENSP00000315130 | Clusterin; Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amy [...] |
| APBA3 protein network | https://string-db.org/network/9606.ENSP00000315136 | Amyloid-beta A4 precursor protein-binding family A member 3; May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A [...] |
| SGPP2 protein network | https://string-db.org/network/9606.ENSP00000315137 | Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sp [...] |
| METAP1D protein network | https://string-db.org/network/9606.ENSP00000315152 | Methionine aminopeptidase 1D, mitochondrial; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is [...] |
| ALOX12B protein network | https://string-db.org/network/9606.ENSP00000315167 | Arachidonate 12-lipoxygenase, 12R-type; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectr [...] |
| SHQ1 protein network | https://string-db.org/network/9606.ENSP00000315182 | Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthes [...] |
| CREG2 protein network | https://string-db.org/network/9606.ENSP00000315203 | Protein CREG2; Cellular repressor of E1A stimulated genes 2 |
| FAM71C protein network | https://string-db.org/network/9606.ENSP00000315247 | Protein FAM71C; Family with sequence similarity 71 member C |
| GLTP protein network | https://string-db.org/network/9606.ENSP00000315263 | Glycolipid transfer protein; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transf [...] |
| DYNAP protein network | https://string-db.org/network/9606.ENSP00000315265 | Dynactin-associated protein; Plays a role in the regulation of cell proliferation. Promotes activation of the AKT1 signaling pathway. Promotes phosphorylation of AKT1 at 'Ser-473' |
| KIAA1549L protein network | https://string-db.org/network/9606.ENSP00000315295 | UPF0606 protein KIAA1549L; KIAA1549 like; Belongs to the UPF0606 family |
| CALML3 protein network | https://string-db.org/network/9606.ENSP00000315299 | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 he [...] |
| D2HGDH protein network | https://string-db.org/network/9606.ENSP00000315351 | D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate |
| ARL6IP6 protein network | https://string-db.org/network/9606.ENSP00000315357 | ADP ribosylation factor like GTPase 6 interacting protein 6; Belongs to the ARL6IP6 family |
| C5orf46 protein network | https://string-db.org/network/9606.ENSP00000315370 | Uncharacterized protein C5orf46; Chromosome 5 open reading frame 46 |
| ANO5 protein network | https://string-db.org/network/9606.ENSP00000315371 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity; Anoctamins |
| PRPF3 protein network | https://string-db.org/network/9606.ENSP00000315379 | U4/U6 small nuclear ribonucleoprotein Prp3; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonuc [...] |
| ASPRV1 protein network | https://string-db.org/network/9606.ENSP00000315383 | Retroviral-like aspartic protease 1; Gag like LTR retrotransposon derived genes |
| KDELC2 protein network | https://string-db.org/network/9606.ENSP00000315386 | KDEL motif-containing protein 2; Glycosyltransferase family 90; Belongs to the KDELC family |
| TMEM102 protein network | https://string-db.org/network/9606.ENSP00000315387 | Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway |
| MRPS31 protein network | https://string-db.org/network/9606.ENSP00000315397 | Mitochondrial ribosomal protein S31 |
| OSBPL3 protein network | https://string-db.org/network/9606.ENSP00000315410 | Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA an [...] |
| ALX1 protein network | https://string-db.org/network/9606.ENSP00000315417 | ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Mo [...] |
| DSCAML1 protein network | https://string-db.org/network/9606.ENSP00000315465 | Down syndrome cell adhesion molecule-like protein 1; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same [...] |
| GIMAP7 protein network | https://string-db.org/network/9606.ENSP00000315474 | GTPase IMAP family member 7; The dimer has GTPase activity; the active site contains residues from both subunits; GTPases, IMAP |
| EXOSC4 protein network | https://string-db.org/network/9606.ENSP00000315476 | Exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| CD209 protein network | https://string-db.org/network/9606.ENSP00000315477 | CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis o [...] |
| HKR1 protein network | https://string-db.org/network/9606.ENSP00000315505 | Krueppel-related zinc finger protein 1; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SPEM1 protein network | https://string-db.org/network/9606.ENSP00000315554 | Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis |
| C2orf57 protein network | https://string-db.org/network/9606.ENSP00000315557 | Testis-expressed protein 44; Chromosome 2 open reading frame 57 |
| LGALS9B protein network | https://string-db.org/network/9606.ENSP00000315564 | Galectin-9B; Binds galactosides; Galectins |
| AVL9 protein network | https://string-db.org/network/9606.ENSP00000315568 | Late secretory pathway protein AVL9 homolog; Functions in cell migration |
| DIS3L2 protein network | https://string-db.org/network/9606.ENSP00000315569 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation [...] |
| CHRNA3 protein network | https://string-db.org/network/9606.ENSP00000315602 | Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| ERICH5 protein network | https://string-db.org/network/9606.ENSP00000315614 | Glutamate-rich protein 5; Glutamate rich 5 |
| SWAP70 protein network | https://string-db.org/network/9606.ENSP00000315630 | Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase rece [...] |
| TMEM25 protein network | https://string-db.org/network/9606.ENSP00000315635 | In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability. |
| TYMS protein network | https://string-db.org/network/9606.ENSP00000315644 | Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway |
| KCNG2 protein network | https://string-db.org/network/9606.ENSP00000315654 | Potassium voltage-gated channel subfamily G member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belo [...] |
| DNMBP protein network | https://string-db.org/network/9606.ENSP00000315659 | Dynamin-binding protein; Scaffold protein that links dynamin with actin- regulating proteins. May play a role in membrane trafficking between the cell surface and the Golgi (By similarity); Class [...] |
| ZNF18 protein network | https://string-db.org/network/9606.ENSP00000315664 | Zinc finger protein 18; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PEX7 protein network | https://string-db.org/network/9606.ENSP00000315680 | Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import; Belongs to the WD repeat peroxin [...] |
| PAM16 protein network | https://string-db.org/network/9606.ENSP00000315693 | Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase a [...] |
| CHAF1B protein network | https://string-db.org/network/9606.ENSP00000315700 | Chromatin assembly factor 1 subunit B; Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 per [...] |
| MOB4 protein network | https://string-db.org/network/9606.ENSP00000315702 | MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family |
| SSH1 protein network | https://string-db.org/network/9606.ENSP00000315713 | Protein phosphatase Slingshot homolog 1; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequ [...] |
| METRNL protein network | https://string-db.org/network/9606.ENSP00000315731 | Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following co [...] |
| CCNG2 protein network | https://string-db.org/network/9606.ENSP00000315743 | Cyclin-G2; May play a role in growth regulation and in negative regulation of cell cycle progression; Belongs to the cyclin family. Cyclin G subfamily |
| STAT2 protein network | https://string-db.org/network/9606.ENSP00000315768 | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding [...] |
| NDUFS8 protein network | https://string-db.org/network/9606.ENSP00000315774 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...] |
| COG4 protein network | https://string-db.org/network/9606.ENSP00000315775 | Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1; Belongs t [...] |
| CSTF3 protein network | https://string-db.org/network/9606.ENSP00000315791 | Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs |
| ZNF575 protein network | https://string-db.org/network/9606.ENSP00000315870 | Zinc finger protein 575; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ANXA2R protein network | https://string-db.org/network/9606.ENSP00000315915 | Annexin-2 receptor; May act as a receptor for annexin II on marrow stromal cells to induce osteoclast formation |
| AHCYL2 protein network | https://string-db.org/network/9606.ENSP00000315931 | Adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sen [...] |
| HOXD8 protein network | https://string-db.org/network/9606.ENSP00000315949 | Homeobox protein Hox-D8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| DPY19L2 protein network | https://string-db.org/network/9606.ENSP00000315988 | Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins (By similarity). Required during spermatogenesis fo [...] |
| LILRB1 protein network | https://string-db.org/network/9606.ENSP00000315997 | Leukocyte immunoglobulin-like receptor subfamily B member 1; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a hum [...] |
| SCAMP4 protein network | https://string-db.org/network/9606.ENSP00000316007 | Secretory carrier-associated membrane protein 4; Probably involved in membrane protein trafficking; Secretory carrier membrane proteins |
| SPAG11A protein network | https://string-db.org/network/9606.ENSP00000316012 | Sperm associated antigen 11A; Belongs to the SPAG11 family |
| TLN1 protein network | https://string-db.org/network/9606.ENSP00000316029 | Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact an [...] |
| NUP98 protein network | https://string-db.org/network/9606.ENSP00000316032 | Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. M [...] |
| HNRNPA0 protein network | https://string-db.org/network/9606.ENSP00000316042 | Heterogeneous nuclear ribonucleoprotein A0; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of c [...] |
| DVL3 protein network | https://string-db.org/network/9606.ENSP00000316054 | Segment polarity protein dishevelled homolog DVL-3; May play a role in the signal transduction pathway mediated by multiple Wnt genes; Dishevelled segment polarity proteins |
| AGGF1 protein network | https://string-db.org/network/9606.ENSP00000316109 | Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting th [...] |
| CCDC101 protein network | https://string-db.org/network/9606.ENSP00000316114 | SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and bin [...] |
| SYNE4 protein network | https://string-db.org/network/9606.ENSP00000316130 | Nesprin-4; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic intera [...] |
| DRICH1 protein network | https://string-db.org/network/9606.ENSP00000316137 | Aspartate-rich protein 1; Aspartate rich 1 |
| SFTPC protein network | https://string-db.org/network/9606.ENSP00000316152 | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air s [...] |
| B3GNT5 protein network | https://string-db.org/network/9606.ENSP00000316173 | Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on g [...] |
| UBE2N protein network | https://string-db.org/network/9606.ENSP00000316176 | Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination doe [...] |
| CLEC4M protein network | https://string-db.org/network/9606.ENSP00000316228 | C-type lectin domain family 4 member M; Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently [...] |
| HTR1A protein network | https://string-db.org/network/9606.ENSP00000316244 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes [...] |
| OR2Z1 protein network | https://string-db.org/network/9606.ENSP00000316284 | Olfactory receptor 2Z1; Odorant receptor; Olfactory receptors, family 2 |
| SCD5 protein network | https://string-db.org/network/9606.ENSP00000316329 | Stearoyl-CoA desaturase 5; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyze [...] |
| FARS2 protein network | https://string-db.org/network/9606.ENSP00000316335 | Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m- [...] |
| BAIAP2 protein network | https://string-db.org/network/9606.ENSP00000316338 | Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganiz [...] |
| USP9X protein network | https://string-db.org/network/9606.ENSP00000316357 | Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulat [...] |
| DLGAP1 protein network | https://string-db.org/network/9606.ENSP00000316377 | Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family |
| CSH1 protein network | https://string-db.org/network/9606.ENSP00000316416 | Chorionic somatomammotropin hormone 1; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR thr [...] |
| PACS1 protein network | https://string-db.org/network/9606.ENSP00000316454 | Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Control [...] |
| C20orf197 protein network | https://string-db.org/network/9606.ENSP00000316457 | Uncharacterized protein C20orf197; Chromosome 20 open reading frame 197 |
| DEGS1 protein network | https://string-db.org/network/9606.ENSP00000316476 | Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine); Fatty acid desaturases |
| KCTD14 protein network | https://string-db.org/network/9606.ENSP00000316482 | BTB/POZ domain-containing protein KCTD14; Potassium channel tetramerization domain containing 14 |
| FCAMR protein network | https://string-db.org/network/9606.ENSP00000316491 | High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytos [...] |
| DCAF4L2 protein network | https://string-db.org/network/9606.ENSP00000316496 | DDB1- and CUL4-associated factor 4-like protein 2; DDB1 and CUL4 associated factor 4 like 2; WD repeat domain containing |
| TLK2 protein network | https://string-db.org/network/9606.ENSP00000316512 | Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromos [...] |
| OR9A2 protein network | https://string-db.org/network/9606.ENSP00000316518 | Olfactory receptor 9A2; Odorant receptor; Olfactory receptors, family 9 |
| ZNF609 protein network | https://string-db.org/network/9606.ENSP00000316527 | Zinc finger protein 609; Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with N [...] |
| TMEM132E protein network | https://string-db.org/network/9606.ENSP00000316532 | Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing; Belongs to the TMEM132 family |
| RAPH1 protein network | https://string-db.org/network/9606.ENSP00000316543 | Ras-associated and pleckstrin homology domains-containing protein 1; Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhe [...] |
| SUZ12 protein network | https://string-db.org/network/9606.ENSP00000316578 | Polycomb protein SUZ12; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional r [...] |
| RANBP10 protein network | https://string-db.org/network/9606.ENSP00000316589 | Ran-binding protein 10; Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with re [...] |
| GTPBP6 protein network | https://string-db.org/network/9606.ENSP00000316598 | Putative GTP-binding protein 6; Pseudoautosomal region 1 |
| CNGB3 protein network | https://string-db.org/network/9606.ENSP00000316605 | Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which le [...] |
| SWI5 protein network | https://string-db.org/network/9606.ENSP00000316609 | DNA repair protein SWI5 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination |
| RNF152 protein network | https://string-db.org/network/9606.ENSP00000316628 | E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and [...] |
| OSBPL2 protein network | https://string-db.org/network/9606.ENSP00000316649 | Oxysterol-binding protein-related protein 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Binds 25-hydroxycholesterol; [...] |
| ACTL9 protein network | https://string-db.org/network/9606.ENSP00000316674 | Actin-like protein 9; Actin related proteins |
| PVRIG protein network | https://string-db.org/network/9606.ENSP00000316675 | Transmembrane protein PVRIG; Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T [...] |
| KIAA1731 protein network | https://string-db.org/network/9606.ENSP00000316681 | Centrosomal protein of 295 kDa; Centriole-enriched protein that mediates centriole-to- centrosome conversion at late mitosis, but is dispensable for cartwheel removal or centriole disengagement |
| RHOJ protein network | https://string-db.org/network/9606.ENSP00000316729 | Rho-related GTP-binding protein RhoJ; GTP-binding protein with GTPase activity. Elicits the formation of F-actin-rich structures in fibroblasts and is involved in the regulation of cell morpholog [...] |
| LCE1D protein network | https://string-db.org/network/9606.ENSP00000316737 | Late cornified envelope protein 1D; Precursors of the cornified envelope of the stratum corneum |
| WBSCR28 protein network | https://string-db.org/network/9606.ENSP00000316775 | Transmembrane protein 270; Williams-Beuren syndrome chromosome region 28 |
| BIN1 protein network | https://string-db.org/network/9606.ENSP00000316779 | Myc box-dependent-interacting protein 1; May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation; N-BAR domain cont [...] |
| NBPF3 protein network | https://string-db.org/network/9606.ENSP00000316782 | Neuroblastoma breakpoint family member 3; NBPF member 3; Belongs to the NBPF family |
| HSD11B2 protein network | https://string-db.org/network/9606.ENSP00000316786 | Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonse [...] |
| ZCCHC5 protein network | https://string-db.org/network/9606.ENSP00000316794 | Retrotransposon Gag-like protein 3; May function as a transcriptional regulator. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal |
| PITPNA protein network | https://string-db.org/network/9606.ENSP00000316809 | Phosphatidylinositol transfer protein alpha isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes; Phosphatidylinositol transfer proteins |
| SIX5 protein network | https://string-db.org/network/9606.ENSP00000316842 | Homeobox protein SIX5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCA [...] |
| ARHGEF4 protein network | https://string-db.org/network/9606.ENSP00000316845 | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex [...] |
| GPM6B protein network | https://string-db.org/network/9606.ENSP00000316861 | cDNA FLJ54144, highly similar to Neuronal membrane glycoprotein M6-b; Glycoprotein M6B |
| LEPREL1 protein network | https://string-db.org/network/9606.ENSP00000316881 | Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post- translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A [...] |
| LIMCH1 protein network | https://string-db.org/network/9606.ENSP00000316891 | LIM and calponin homology domains 1 |
| C12orf54 protein network | https://string-db.org/network/9606.ENSP00000316898 | Uncharacterized protein C12orf54; Chromosome 12 open reading frame 54 |
| SFXN1 protein network | https://string-db.org/network/9606.ENSP00000316905 | Sideroflexin-1; Might be involved in the transport of a component required for iron utilization into or out of the mitochondria; Sideroflexins |
| SLC17A8 protein network | https://string-db.org/network/9606.ENSP00000316909 | Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic p [...] |
| ACSS1 protein network | https://string-db.org/network/9606.ENSP00000316924 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic c [...] |
| TMEM31 protein network | https://string-db.org/network/9606.ENSP00000316940 | Transmembrane protein 31 |
| CLK4 protein network | https://string-db.org/network/9606.ENSP00000316948 | Dual specificity protein kinase CLK4; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spl [...] |
| MYEF2 protein network | https://string-db.org/network/9606.ENSP00000316950 | Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function a [...] |
| OR7A5 protein network | https://string-db.org/network/9606.ENSP00000316955 | Olfactory receptor 7A5; Odorant receptor; Olfactory receptors, family 7 |
| TM6SF1 protein network | https://string-db.org/network/9606.ENSP00000317000 | Transmembrane 6 superfamily member 1; May function as sterol isomerase; Belongs to the TM6SF family |
| GCNT4 protein network | https://string-db.org/network/9606.ENSP00000317027 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. [...] |
| RMI1 protein network | https://string-db.org/network/9606.ENSP00000317039 | RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA [...] |
| SNRNP200 protein network | https://string-db.org/network/9606.ENSP00000317123 | U5 small nuclear ribonucleoprotein 200 kDa helicase; RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spli [...] |
| PLXND1 protein network | https://string-db.org/network/9606.ENSP00000317128 | Plexin-D1; Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wi [...] |
| PIBF1 protein network | https://string-db.org/network/9606.ENSP00000317144 | Progesterone-induced-blocking factor 1; Isoform 1: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitmen [...] |
| CYC1 protein network | https://string-db.org/network/9606.ENSP00000317159 | Cytochrome c1, heme protein, mitochondrial; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome [...] |
| KRBA1 protein network | https://string-db.org/network/9606.ENSP00000317165 | Protein KRBA1; KRAB-A domain containing 1 |
| TIGD2 protein network | https://string-db.org/network/9606.ENSP00000317170 | Tigger transposable element-derived protein 2; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| PLEKHD1 protein network | https://string-db.org/network/9606.ENSP00000317175 | Pleckstrin homology and coiled-coil domain containing D1; Belongs to the PLEKHD1 family |
| PLD6 protein network | https://string-db.org/network/9606.ENSP00000317177 | Mitochondrial cardiolipin hydrolase; Endonuclease that plays a critical role in PIWI- interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the ac [...] |
| CAPN6 protein network | https://string-db.org/network/9606.ENSP00000317214 | Calpain-6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interactio [...] |
| SAMD4B protein network | https://string-db.org/network/9606.ENSP00000317224 | Protein Smaug homolog 2; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A; Armadillo-like helical domain containing |
| FKBP10 protein network | https://string-db.org/network/9606.ENSP00000317232 | Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing |
| LMO7DN protein network | https://string-db.org/network/9606.ENSP00000317235 | LMO7 downstream neighbor |
| CPNE1 protein network | https://string-db.org/network/9606.ENSP00000317257 | Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent [...] |
| MET protein network | https://string-db.org/network/9606.ENSP00000317272 | Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates m [...] |
| FAM220A protein network | https://string-db.org/network/9606.ENSP00000317289 | Protein FAM220A; May negatively regulate STAT3 |
| LPCAT4 protein network | https://string-db.org/network/9606.ENSP00000317300 | Lysophospholipid acyltransferase LPCAT4; Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolam [...] |
| CABP1 protein network | https://string-db.org/network/9606.ENSP00000317310 | Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation [...] |
| UBASH3A protein network | https://string-db.org/network/9606.ENSP00000317327 | Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target [...] |
| SSR4 protein network | https://string-db.org/network/9606.ENSP00000317331 | Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; B [...] |
| SNX18 protein network | https://string-db.org/network/9606.ENSP00000317332 | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. [...] |
| NEUROG2 protein network | https://string-db.org/network/9606.ENSP00000317333 | Neurogenin-2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'); Basic helix-loop-helix proteins |
| TCP1 protein network | https://string-db.org/network/9606.ENSP00000317334 | T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex in [...] |
| OR13D1 protein network | https://string-db.org/network/9606.ENSP00000317357 | Olfactory receptor 13D1; Odorant receptor; Olfactory receptors, family 13 |
| MRPS11 protein network | https://string-db.org/network/9606.ENSP00000317376 | Mitochondrial ribosomal protein S11 |
| GLS protein network | https://string-db.org/network/9606.ENSP00000317379 | Glutaminase kidney isoform, mitochondrial; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates [...] |
| SLC36A4 protein network | https://string-db.org/network/9606.ENSP00000317382 | Proton-coupled amino acid transporter 4; Functions as a sodium-independent electroneutral transporter for tryptophan, proline and alanine. Inhibited by sarcosine; Belongs to the amino acid/polyam [...] |
| PCNXL4 protein network | https://string-db.org/network/9606.ENSP00000317396 | Pecanex-like 4 (Drosophila); Belongs to the pecanex family |
| CHST13 protein network | https://string-db.org/network/9606.ENSP00000317404 | Carbohydrate sulfotransferase 13; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant pro [...] |
| ENTHD1 protein network | https://string-db.org/network/9606.ENSP00000317431 | ENTH domain containing 1 |
| CNPY1 protein network | https://string-db.org/network/9606.ENSP00000317439 | Canopy FGF signaling regulator 1; Belongs to the canopy family |
| PSAPL1 protein network | https://string-db.org/network/9606.ENSP00000317445 | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids |
| CHMP6 protein network | https://string-db.org/network/9606.ENSP00000317468 | Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| BBS1 protein network | https://string-db.org/network/9606.ENSP00000317469 | Bardet-Biedl syndrome 1 protein; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is require [...] |
| RABGGTB protein network | https://string-db.org/network/9606.ENSP00000317473 | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -X [...] |
| OR4F4 protein network | https://string-db.org/network/9606.ENSP00000317482 | Olfactory receptor 4F4; Odorant receptor; Olfactory receptors, family 4 |
| WASH4P protein network | https://string-db.org/network/9606.ENSP00000317542 | Putative WAS protein family homolog 4; May act as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, pla [...] |
| EID2B protein network | https://string-db.org/network/9606.ENSP00000317564 | EP300-interacting inhibitor of differentiation 2B; Acts as a repressor of MYOD-dependent transcription, glucocorticoid receptor-dependent transcription, and muscle differentiation |
| ADRBK2 protein network | https://string-db.org/network/9606.ENSP00000317578 | Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors |
| C16orf58 protein network | https://string-db.org/network/9606.ENSP00000317579 | RUS1 family protein C16orf58; Chromosome 16 open reading frame 58; Belongs to the RUS1 family |
| NEUROG1 protein network | https://string-db.org/network/9606.ENSP00000317580 | Neurogenin-1; Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromati [...] |
| TPPP2 protein network | https://string-db.org/network/9606.ENSP00000317595 | Tubulin polymerization-promoting protein family member 2; May bind tubulin but has no microtubule bundling activity; Tubulin polymerization promoting proteins |
| ZNF518B protein network | https://string-db.org/network/9606.ENSP00000317614 | Zinc finger protein 518B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RECQL5 protein network | https://string-db.org/network/9606.ENSP00000317636 | ATP-dependent DNA helicase Q5; Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage s [...] |
| C12orf40 protein network | https://string-db.org/network/9606.ENSP00000317671 | Uncharacterized protein C12orf40; Chromosome 12 open reading frame 40 |
| APOL1 protein network | https://string-db.org/network/9606.ENSP00000317674 | Apolipoprotein L1; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver |
| ZFP42 protein network | https://string-db.org/network/9606.ENSP00000317686 | Zinc finger protein 42 homolog; Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA anti [...] |
| RPP25 protein network | https://string-db.org/network/9606.ENSP00000317691 | Ribonuclease P protein subunit p25; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. This subunit bind [...] |
| STX4 protein network | https://string-db.org/network/9606.ENSP00000317714 | Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 [...] |
| PIPOX protein network | https://string-db.org/network/9606.ENSP00000317721 | Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline |
| HARBI1 protein network | https://string-db.org/network/9606.ENSP00000317743 | Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity; DNA transposon derived genes |
| COX5A protein network | https://string-db.org/network/9606.ENSP00000317780 | Cytochrome c oxidase subunit 5A, mitochondrial; This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| SPTBN5 protein network | https://string-db.org/network/9606.ENSP00000317790 | Spectrin beta, non-erythrocytic 5; Spectrins |
| SH2D3C protein network | https://string-db.org/network/9606.ENSP00000317817 | SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-depende [...] |
| PRR15 protein network | https://string-db.org/network/9606.ENSP00000317836 | Proline-rich protein 15; May have a role in proliferation and/or differentiation |
| CES2 protein network | https://string-db.org/network/9606.ENSP00000317842 | Cocaine esterase; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl [...] |
| RBBP6 protein network | https://string-db.org/network/9606.ENSP00000317872 | E3 ubiquitin-protein ligase RBBP6; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome. May play a role as a scaffold protein to promot [...] |
| TNIP1 protein network | https://string-db.org/network/9606.ENSP00000317891 | TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa- B-dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link [...] |
| RPTN protein network | https://string-db.org/network/9606.ENSP00000317895 | Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium; EF-hand domain containing |
| CEP57 protein network | https://string-db.org/network/9606.ENSP00000317902 | Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring- like structures around microtubules. Mediates nuclear [...] |
| R3HDM2 protein network | https://string-db.org/network/9606.ENSP00000317903 | R3H domain containing 2 |
| GYS1 protein network | https://string-db.org/network/9606.ENSP00000317904 | Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Glycosyl transferases group 1 domain containing |
| EEA1 protein network | https://string-db.org/network/9606.ENSP00000317955 | Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking; Zinc fingers FYVE-type |
| WDTC1 protein network | https://string-db.org/network/9606.ENSP00000317971 | WD and tetratricopeptide repeats protein 1; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| ROCK2 protein network | https://string-db.org/network/9606.ENSP00000317985 | Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organizat [...] |
| NOC2L protein network | https://string-db.org/network/9606.ENSP00000317992 | Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53- [...] |
| DUOX1 protein network | https://string-db.org/network/9606.ENSP00000317997 | Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-me [...] |
| KIAA0196 protein network | https://string-db.org/network/9606.ENSP00000318016 | WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...] |
| ODF3L2 protein network | https://string-db.org/network/9606.ENSP00000318029 | Outer dense fiber of sperm tails 3 like 2 |
| RPRML protein network | https://string-db.org/network/9606.ENSP00000318032 | Reprimo-like protein; Reprimo like |
| EGR3 protein network | https://string-db.org/network/9606.ENSP00000318057 | Early growth response protein 3; Probable transcription factor involved in muscle spindle development; Belongs to the EGR C2H2-type zinc-finger protein family |
| ENPP4 protein network | https://string-db.org/network/9606.ENSP00000318066 | Bis(5'-adenosyl)-triphosphatase ENPP4; Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of v [...] |
| MC5R protein network | https://string-db.org/network/9606.ENSP00000318077 | Melanocortin receptor 5; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible m [...] |
| HINFP protein network | https://string-db.org/network/9606.ENSP00000318085 | Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene tra [...] |
| MAP7D3 protein network | https://string-db.org/network/9606.ENSP00000318086 | MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules |
| SCMH1 protein network | https://string-db.org/network/9606.ENSP00000318094 | Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the [...] |
| CLDN22 protein network | https://string-db.org/network/9606.ENSP00000318113 | Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| C9orf139 protein network | https://string-db.org/network/9606.ENSP00000318119 | Uncharacterized protein C9orf139; Chromosome 9 open reading frame 139 |
| BLOC1S4 protein network | https://string-db.org/network/9606.ENSP00000318128 | Biogenesis of lysosome-related organelles complex 1 subunit 4; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| PNMAL1 protein network | https://string-db.org/network/9606.ENSP00000318131 | Paraneoplastic antigen-like protein 8A; Paraneoplastic Ma antigen family-like 1 |
| FUT7 protein network | https://string-db.org/network/9606.ENSP00000318142 | Alpha-(1,3)-fucosyltransferase 7; Catalyzes alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens; Belongs to the glycosyltransferase 10 family |
| EDEM3 protein network | https://string-db.org/network/9606.ENSP00000318147 | ER degradation-enhancing alpha-mannosidase-like protein 3; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose [...] |
| MRFAP1L1 protein network | https://string-db.org/network/9606.ENSP00000318154 | Morf4 family associated protein 1 like 1 |
| MRPS24 protein network | https://string-db.org/network/9606.ENSP00000318158 | Mitochondrial ribosomal protein S24; Belongs to the universal ribosomal protein uS3 family |
| OS9 protein network | https://string-db.org/network/9606.ENSP00000318165 | Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as imprope [...] |
| PRKRA protein network | https://string-db.org/network/9606.ENSP00000318176 | Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha [...] |
| FUBP3 protein network | https://string-db.org/network/9606.ENSP00000318177 | Far upstream element-binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression |
| NCL protein network | https://string-db.org/network/9606.ENSP00000318195 | Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensat [...] |
| TUBA3E protein network | https://string-db.org/network/9606.ENSP00000318197 | Tubulin alpha-3E chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| ZDHHC22 protein network | https://string-db.org/network/9606.ENSP00000318222 | Palmitoyltransferase ZDHHC22; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane; Zinc fingers DHHC-type |
| COL26A1 protein network | https://string-db.org/network/9606.ENSP00000318234 | Collagen type XXVI alpha 1 chain; Collagens |
| CSRNP3 protein network | https://string-db.org/network/9606.ENSP00000318258 | Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis (By similarity); Protein phosphatase 1 r [...] |
| ELMOD3 protein network | https://string-db.org/network/9606.ENSP00000318264 | ELMO domain-containing protein 3; Acts as a GTPase-activating protein (GAP) for ARL2 with low specific activity; Deafness associated genes |
| PROM2 protein network | https://string-db.org/network/9606.ENSP00000318270 | Prominin-2; Prominin 2 |
| RUVBL1 protein network | https://string-db.org/network/9606.ENSP00000318297 | RuvB-like 1; May be able to bind plasminogen at cell surface and enhance plasminogen activation; AAA ATPases |
| FAM46A protein network | https://string-db.org/network/9606.ENSP00000318298 | Putative nucleotidyltransferase FAM46A; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family |
| MPI protein network | https://string-db.org/network/9606.ENSP00000318318 | Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the mannose-6- [...] |
| BCKDHB protein network | https://string-db.org/network/9606.ENSP00000318351 | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It cont [...] |
| MRFAP1 protein network | https://string-db.org/network/9606.ENSP00000318352 | Morf4 family associated protein 1 |
| AQP10 protein network | https://string-db.org/network/9606.ENSP00000318355 | Aquaporin-10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform [...] |
| ZNF513 protein network | https://string-db.org/network/9606.ENSP00000318373 | Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance; Zinc fingers C2H2-type |
| LENG8 protein network | https://string-db.org/network/9606.ENSP00000318374 | Leukocyte receptor cluster member 8 |
| KIAA0319L protein network | https://string-db.org/network/9606.ENSP00000318406 | Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R |
| LINS protein network | https://string-db.org/network/9606.ENSP00000318423 | Lines homolog (Drosophila) |
| CCDC114 protein network | https://string-db.org/network/9606.ENSP00000318429 | Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms; Belongs to the ODA1/DCC2 family |
| FDCSP protein network | https://string-db.org/network/9606.ENSP00000318437 | Follicular dendritic cell secreted peptide; Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells |
| YME1L1 protein network | https://string-db.org/network/9606.ENSP00000318480 | ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial interm [...] |
| CDK5R1 protein network | https://string-db.org/network/9606.ENSP00000318486 | Cyclin-dependent kinase 5 activator 1; P35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morp [...] |
| BACE1 protein network | https://string-db.org/network/9606.ENSP00000318585 | Beta-secretase 1; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, [...] |
| PRTFDC1 protein network | https://string-db.org/network/9606.ENSP00000318602 | Phosphoribosyltransferase domain-containing protein 1; Has low, barely detectable phosphoribosyltransferase activity (in vitro). Binds GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP) [...] |
| MAF1 protein network | https://string-db.org/network/9606.ENSP00000318604 | Repressor of RNA polymerase III transcription MAF1 homolog; Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. [...] |
| LDLRAD3 protein network | https://string-db.org/network/9606.ENSP00000318607 | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide product [...] |
| TRIM73 protein network | https://string-db.org/network/9606.ENSP00000318615 | Tripartite motif containing 73; Belongs to the TRIM/RBCC family |
| VPS37A protein network | https://string-db.org/network/9606.ENSP00000318629 | Vacuolar protein sorting-associated protein 37A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...] |
| SUMO4 protein network | https://string-db.org/network/9606.ENSP00000318635 | Small ubiquitin-related modifier 4; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate pr [...] |
| INTS3 protein network | https://string-db.org/network/9606.ENSP00000318641 | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent [...] |
| RPS15A protein network | https://string-db.org/network/9606.ENSP00000318646 | Ribosomal protein S15a; Belongs to the universal ribosomal protein uS8 family |
| GREM2 protein network | https://string-db.org/network/9606.ENSP00000318650 | Gremlin-2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morph [...] |
| VSIG2 protein network | https://string-db.org/network/9606.ENSP00000318684 | V-set and immunoglobulin domain containing 2 |
| HSPH1 protein network | https://string-db.org/network/9606.ENSP00000318687 | Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate pro [...] |
| GCFC2 protein network | https://string-db.org/network/9606.ENSP00000318690 | GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC- rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and cal [...] |
| TUBB6 protein network | https://string-db.org/network/9606.ENSP00000318697 | Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...] |
| FAM9B protein network | https://string-db.org/network/9606.ENSP00000318716 | Protein FAM9B; Family with sequence similarity 9 member B; Belongs to the FAM9 family |
| AQP11 protein network | https://string-db.org/network/9606.ENSP00000318770 | Aquaporin-11; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes |
| BHLHE22 protein network | https://string-db.org/network/9606.ENSP00000318799 | Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, pro [...] |
| SYTL2 protein network | https://string-db.org/network/9606.ENSP00000318803 | Synaptotagmin-like protein 2; Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immu [...] |
| CRLF3 protein network | https://string-db.org/network/9606.ENSP00000318804 | Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression; Fibronectin type III domain containing |
| TPO protein network | https://string-db.org/network/9606.ENSP00000318820 | Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4); Belongs to the peroxidase family. XPO subfamily |
| GCC1 protein network | https://string-db.org/network/9606.ENSP00000318821 | GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure |
| BID protein network | https://string-db.org/network/9606.ENSP00000318822 | BH3-interacting domain death agonist; The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and ap [...] |
| OR10H4 protein network | https://string-db.org/network/9606.ENSP00000318834 | Olfactory receptor 10H4; Odorant receptor; Olfactory receptors, family 10 |
| SF3B2 protein network | https://string-db.org/network/9606.ENSP00000318861 | Splicing factor 3B subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| CYP8B1 protein network | https://string-db.org/network/9606.ENSP00000318867 | 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha-dihydroxy [...] |
| SHMT1 protein network | https://string-db.org/network/9606.ENSP00000318868 | Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine |
| OR4F21 protein network | https://string-db.org/network/9606.ENSP00000318878 | Olfactory receptor 4F21; Odorant receptor; Olfactory receptors, family 4 |
| FMN2 protein network | https://string-db.org/network/9606.ENSP00000318884 | Formin-2; Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Actin-binding protein that is involved [...] |
| SOBP protein network | https://string-db.org/network/9606.ENSP00000318900 | Sine oculis-binding protein homolog; Implicated in development of the cochlea |
| CA13 protein network | https://string-db.org/network/9606.ENSP00000318912 | Carbonic anhydrase 13; Reversible hydration of carbon dioxide; Carbonic anhydrases |
| PNMA1 protein network | https://string-db.org/network/9606.ENSP00000318914 | Paraneoplastic Ma antigens; Belongs to the PNMA family |
| MARCO protein network | https://string-db.org/network/9606.ENSP00000318916 | Macrophage receptor MARCO; Pattern recognition receptor (PRR) which binds Gram- positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages [...] |
| TRAF7 protein network | https://string-db.org/network/9606.ENSP00000318944 | E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DD [...] |
| OR52K2 protein network | https://string-db.org/network/9606.ENSP00000318956 | Olfactory receptor 52K2; Odorant receptor; Olfactory receptors, family 52 |
| SLC35C2 protein network | https://string-db.org/network/9606.ENSP00000318960 | Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a f [...] |
| PINX1 protein network | https://string-db.org/network/9606.ENSP00000318966 | PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 bindin [...] |
| FAM133A protein network | https://string-db.org/network/9606.ENSP00000318974 | Protein FAM133A; Family with sequence similarity 133 member A |
| GEN1 protein network | https://string-db.org/network/9606.ENSP00000318977 | Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in w [...] |
| EPSTI1 protein network | https://string-db.org/network/9606.ENSP00000318982 | Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation (By similarity). Might play a role in RELA/p [...] |
| NSUN3 protein network | https://string-db.org/network/9606.ENSP00000318986 | tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial; Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt-tRNA(Met). mt- [...] |
| OR11H4 protein network | https://string-db.org/network/9606.ENSP00000318997 | Olfactory receptor 11H4; Odorant receptor; Olfactory receptors, family 11 |
| C11orf16 protein network | https://string-db.org/network/9606.ENSP00000318999 | Uncharacterized protein C11orf16; Chromosome 11 open reading frame 16 |
| CCDC71 protein network | https://string-db.org/network/9606.ENSP00000319006 | Coiled-coil domain containing 71 |
| TMEM45A protein network | https://string-db.org/network/9606.ENSP00000319009 | Transmembrane protein 45A; Belongs to the TMEM45 family |
| CETN1 protein network | https://string-db.org/network/9606.ENSP00000319052 | Centrin-1; Plays a fundamental role in microtubule-organizing center structure and function; EF-hand domain containing |
| ZNF77 protein network | https://string-db.org/network/9606.ENSP00000319053 | Zinc finger protein 77; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CAMK2G protein network | https://string-db.org/network/9606.ENSP00000319060 | Calcium/calmodulin-dependent protein kinase type II subunit gamma; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, [...] |
| OR11H6 protein network | https://string-db.org/network/9606.ENSP00000319071 | Olfactory receptor 11H6; Odorant receptor; Olfactory receptors, family 11 |
| RAP2B protein network | https://string-db.org/network/9606.ENSP00000319096 | Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of [...] |
| SUPT6H protein network | https://string-db.org/network/9606.ENSP00000319104 | Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the t [...] |
| GSX2 protein network | https://string-db.org/network/9606.ENSP00000319118 | GS homeobox 2; During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, neces [...] |
| DEFB112 protein network | https://string-db.org/network/9606.ENSP00000319126 | Beta-defensin 112; Has antibacterial activity; Defensins, beta |
| PSG11 protein network | https://string-db.org/network/9606.ENSP00000319140 | Pregnancy specific beta-1-glycoprotein 11 |
| CYBRD1 protein network | https://string-db.org/network/9606.ENSP00000319141 | Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating [...] |
| PRMT5 protein network | https://string-db.org/network/9606.ENSP00000319169 | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a prefere [...] |
| KDF1 protein network | https://string-db.org/network/9606.ENSP00000319179 | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter [...] |
| STK17A protein network | https://string-db.org/network/9606.ENSP00000319192 | Serine/threonine-protein kinase 17A; Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species; Death associated protein kinases |
| OR4K17 protein network | https://string-db.org/network/9606.ENSP00000319197 | Olfactory receptor 4K17; Odorant receptor; Olfactory receptors, family 4 |
| OR4L1 protein network | https://string-db.org/network/9606.ENSP00000319217 | Olfactory receptor 4L1; Odorant receptor; Olfactory receptors, family 4 |
| ZNF720 protein network | https://string-db.org/network/9606.ENSP00000319222 | Putative protein ZNF720; Zinc finger protein 720; Zinc fingers C2H2-type |
| PHLDA2 protein network | https://string-db.org/network/9606.ENSP00000319231 | Pleckstrin homology-like domain family A member 2; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing [...] |
| MAGOHB protein network | https://string-db.org/network/9606.ENSP00000319240 | Protein mago nashi homolog 2; Involved in mRNA splicing and in the nonsense-mediated decay (NMD) pathway |
| GPR62 protein network | https://string-db.org/network/9606.ENSP00000319250 | Probable G-protein coupled receptor 62; Orphan receptor; G protein-coupled receptors, Class A orphans |
| GIPC3 protein network | https://string-db.org/network/9606.ENSP00000319254 | PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion; Deafness associated genes |
| CHORDC1 protein network | https://string-db.org/network/9606.ENSP00000319255 | Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play [...] |
| MALT1 protein network | https://string-db.org/network/9606.ENSP00000319279 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomeriz [...] |
| BASP1 protein network | https://string-db.org/network/9606.ENSP00000319281 | Brain abundant membrane attached signal protein 1; Belongs to the BASP1 family |
| ZNF572 protein network | https://string-db.org/network/9606.ENSP00000319305 | Zinc finger protein 572; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR4K13 protein network | https://string-db.org/network/9606.ENSP00000319322 | Olfactory receptor 4K13; Odorant receptor; Olfactory receptors, family 4 |
| LSM10 protein network | https://string-db.org/network/9606.ENSP00000319341 | U7 snRNA-associated Sm-like protein LSm10; Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA pro [...] |
| KCNMB3 protein network | https://string-db.org/network/9606.ENSP00000319370 | Calcium-activated potassium channel subunit beta-3; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...] |
| MAMDC4 protein network | https://string-db.org/network/9606.ENSP00000319388 | Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia |
| ARMC10 protein network | https://string-db.org/network/9606.ENSP00000319412 | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53; Armadillo repeat containing |
| SKA3 protein network | https://string-db.org/network/9606.ENSP00000319417 | Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA [...] |
| CPN2 protein network | https://string-db.org/network/9606.ENSP00000319464 | Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric mod [...] |
| ICOS protein network | https://string-db.org/network/9606.ENSP00000319476 | Inducible T-cell costimulator; Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interac [...] |
| DCUN1D3 protein network | https://string-db.org/network/9606.ENSP00000319482 | DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane. When overexpressed in transformed cells, may promote mesenchymal to epithelial-like c [...] |
| TSPAN16 protein network | https://string-db.org/network/9606.ENSP00000319486 | Tetraspanin-16; Tetraspanin 16; Tetraspanins |
| UGDH protein network | https://string-db.org/network/9606.ENSP00000319501 | UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate |
| OR4K5 protein network | https://string-db.org/network/9606.ENSP00000319511 | Olfactory receptor 4K5; Odorant receptor; Olfactory receptors, family 4 |
| GCSH protein network | https://string-db.org/network/9606.ENSP00000319531 | Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P prote [...] |
| OR2A4 protein network | https://string-db.org/network/9606.ENSP00000319546 | Olfactory receptor 2A4; Odorant receptor; Olfactory receptors, family 2 |
| PRR18 protein network | https://string-db.org/network/9606.ENSP00000319590 | Proline-rich protein 18; Proline rich 18 |
| KCND3 protein network | https://string-db.org/network/9606.ENSP00000319591 | Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I( [...] |
| SNAPC5 protein network | https://string-db.org/network/9606.ENSP00000319597 | snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...] |
| OR4N2 protein network | https://string-db.org/network/9606.ENSP00000319601 | Olfactory receptor 4N2; Odorant receptor; Olfactory receptors, family 4 |
| SULT1C2 protein network | https://string-db.org/network/9606.ENSP00000319622 | Sulfotransferase 1C2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neu [...] |
| IGDCC4 protein network | https://string-db.org/network/9606.ENSP00000319623 | Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family |
| CXCR2 protein network | https://string-db.org/network/9606.ENSP00000319635 | C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is m [...] |
| B3GNT4 protein network | https://string-db.org/network/9606.ENSP00000319636 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosacc [...] |
| DMRTA1 protein network | https://string-db.org/network/9606.ENSP00000319651 | Doublesex- and mab-3-related transcription factor A1; DMRT like family A1; Belongs to the DMRT family |
| OR4M1 protein network | https://string-db.org/network/9606.ENSP00000319654 | Olfactory receptor 4M1; Odorant receptor; Olfactory receptors, family 4 |
| NUDC protein network | https://string-db.org/network/9606.ENSP00000319664 | Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration (By similarity). Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. [...] |
| GPR89A protein network | https://string-db.org/network/9606.ENSP00000319673 | G protein-coupled receptor 89A; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance; Belongs to the Golgi [...] |
| DUOXA2 protein network | https://string-db.org/network/9606.ENSP00000319705 | Dual oxidase maturation factor 2; Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synth [...] |
| AGTRAP protein network | https://string-db.org/network/9606.ENSP00000319713 | Type-1 angiotensin II receptor-associated protein; Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechan [...] |
| FRMD8 protein network | https://string-db.org/network/9606.ENSP00000319726 | Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of T [...] |
| PRSS8 protein network | https://string-db.org/network/9606.ENSP00000319730 | Prostasin; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma [...] |
| RCN2 protein network | https://string-db.org/network/9606.ENSP00000319739 | Reticulocalbin-2; Not known. Binds calcium; EF-hand domain containing |
| GPR4 protein network | https://string-db.org/network/9606.ENSP00000319744 | G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production; G protein-coupled receptors, Class [...] |
| TENC1 protein network | https://string-db.org/network/9606.ENSP00000319756 | Tensin-2; Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling |
| RAB43 protein network | https://string-db.org/network/9606.ENSP00000319781 | Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| NQO1 protein network | https://string-db.org/network/9606.ENSP00000319788 | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in b [...] |
| SERINC4 protein network | https://string-db.org/network/9606.ENSP00000319796 | Serine incorporator 4; Incorporates a polar amino acid serine into membranes and facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids |
| H1FOO protein network | https://string-db.org/network/9606.ENSP00000319799 | Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic mat [...] |
| PCK1 protein network | https://string-db.org/network/9606.ENSP00000319814 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces gluc [...] |
| OPA3 protein network | https://string-db.org/network/9606.ENSP00000319817 | Optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); OPA3, outer mitochondrial membrane lipid metabolism regulator |
| ZNF687 protein network | https://string-db.org/network/9606.ENSP00000319829 | Zinc finger protein 687; May be involved in transcriptional regulation |
| DEF6 protein network | https://string-db.org/network/9606.ENSP00000319831 | Differentially expressed in FDCP 6 homolog; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, R [...] |
| CHDH protein network | https://string-db.org/network/9606.ENSP00000319851 | Choline dehydrogenase, mitochondrial; Choline dehydrogenase |
| EMR2 protein network | https://string-db.org/network/9606.ENSP00000319883 | Adhesion G protein-coupled receptor E2; Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxi [...] |
| C8orf4 protein network | https://string-db.org/network/9606.ENSP00000319914 | Transcriptional and immune response regulator; Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type [...] |
| ITFG1 protein network | https://string-db.org/network/9606.ENSP00000319918 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity); Belongs to the TIP family |
| BBX protein network | https://string-db.org/network/9606.ENSP00000319974 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase |
| B3GNTL1 protein network | https://string-db.org/network/9606.ENSP00000319979 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; Putative glycosyltransferase; Glycosyltransferase family 2 |
| SLC16A6 protein network | https://string-db.org/network/9606.ENSP00000319991 | Monocarboxylate transporter 7; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...] |
| TMEM11 protein network | https://string-db.org/network/9606.ENSP00000319992 | Transmembrane protein 11, mitochondrial; Plays a role in mitochondrial morphogenesis; Belongs to the TMEM11 family |
| CACNB2 protein network | https://string-db.org/network/9606.ENSP00000320025 | Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...] |
| ARHGAP33 protein network | https://string-db.org/network/9606.ENSP00000320038 | Rho GTPase-activating protein 33; May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a down [...] |
| LYPLA1 protein network | https://string-db.org/network/9606.ENSP00000320043 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low l [...] |
| OR4D11 protein network | https://string-db.org/network/9606.ENSP00000320077 | Olfactory receptor 4D11; Odorant receptor; Olfactory receptors, family 4 |
| C3orf58 protein network | https://string-db.org/network/9606.ENSP00000320081 | Deleted in autism protein 1; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PPI3K-AKT-CDK7 signaling cascade; Belongs to the DIA1 family |
| CD276 protein network | https://string-db.org/network/9606.ENSP00000320084 | CD276 antigen; May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role o [...] |
| NKX2-6 protein network | https://string-db.org/network/9606.ENSP00000320089 | Homeobox protein Nkx-2.6; Acts as a transcriptional activator. In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development; NKL subclass homeoboxes and pseudo [...] |
| SH3GL3 protein network | https://string-db.org/network/9606.ENSP00000320092 | Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity); N-BAR domain containing |
| ZNF784 protein network | https://string-db.org/network/9606.ENSP00000320096 | Zinc finger protein 784; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TRIP10 protein network | https://string-db.org/network/9606.ENSP00000320117 | Cdc42-interacting protein 4; Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganiz [...] |
| DYNC1I1 protein network | https://string-db.org/network/9606.ENSP00000320130 | Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargo [...] |
| EZH2 protein network | https://string-db.org/network/9606.ENSP00000320147 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys- 27' (H3K27me) of histone H3, lea [...] |
| PKM protein network | https://string-db.org/network/9606.ENSP00000320171 | Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activati [...] |
| HCLS1 protein network | https://string-db.org/network/9606.ENSP00000320176 | Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lympho [...] |
| GHRHR protein network | https://string-db.org/network/9606.ENSP00000320180 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growt [...] |
| MRPS23 protein network | https://string-db.org/network/9606.ENSP00000320184 | Mitochondrial ribosomal protein S23; Belongs to the mitochondrion-specific ribosomal protein mS23 family |
| ZNF579 protein network | https://string-db.org/network/9606.ENSP00000320188 | Zinc finger protein 579; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CIDEA protein network | https://string-db.org/network/9606.ENSP00000320209 | Cell death activator CIDE-A; Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS [...] |
| SLC26A10 protein network | https://string-db.org/network/9606.ENSP00000320217 | Solute carrier family 26 member 10; Chloride/bicarbonate exchanger; Solute carriers |
| ARSJ protein network | https://string-db.org/network/9606.ENSP00000320219 | Arylsulfatase family member J; Sulfatases |
| CCDC168 protein network | https://string-db.org/network/9606.ENSP00000320232 | Coiled-coil domain containing 168 |
| TIMM22 protein network | https://string-db.org/network/9606.ENSP00000320236 | Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins [...] |
| TRPM7 protein network | https://string-db.org/network/9606.ENSP00000320239 | Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a cent [...] |
| SLC9A9 protein network | https://string-db.org/network/9606.ENSP00000320246 | Sodium/hydrogen exchanger 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved i [...] |
| C3orf17 protein network | https://string-db.org/network/9606.ENSP00000320251 | Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibi [...] |
| OSBPL1A protein network | https://string-db.org/network/9606.ENSP00000320291 | Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GT [...] |
| TUBB3 protein network | https://string-db.org/network/9606.ENSP00000320295 | Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...] |
| OR5AN1 protein network | https://string-db.org/network/9606.ENSP00000320302 | Olfactory receptor 5AN1; Odorant receptor involved in the detection of muscone; Olfactory receptors, family 5 |
| FARSA protein network | https://string-db.org/network/9606.ENSP00000320309 | phenylalanyl-tRNA synthetase alpha subunit; Aminoacyl tRNA synthetases, Class II |
| NEU4 protein network | https://string-db.org/network/9606.ENSP00000320318 | Sialidase-4; May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N- acetylneuraminic [...] |
| NPEPPS protein network | https://string-db.org/network/9606.ENSP00000320324 | Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regula [...] |
| PLA2G16 protein network | https://string-db.org/network/9606.ENSP00000320337 | HRAS-like suppressor 3; Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue. Shows phospholipa [...] |
| ELL3 protein network | https://string-db.org/network/9606.ENSP00000320346 | RNA polymerase II elongation factor ELL3; Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future act [...] |
| ZFP3 protein network | https://string-db.org/network/9606.ENSP00000320347 | Zinc finger protein 3 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IFT22 protein network | https://string-db.org/network/9606.ENSP00000320359 | Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B; Belongs to the small GTPase superfamily. Rab family |
| P2RY13 protein network | https://string-db.org/network/9606.ENSP00000320376 | P2Y purinoceptor 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system; P2Y receptors |
| SLC7A8 protein network | https://string-db.org/network/9606.ENSP00000320378 | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalani [...] |
| UGT2B17 protein network | https://string-db.org/network/9606.ENSP00000320401 | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of thi [...] |
| VPS37D protein network | https://string-db.org/network/9606.ENSP00000320416 | Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into mu [...] |
| S100Z protein network | https://string-db.org/network/9606.ENSP00000320430 | S100 calcium binding protein Z; EF-hand domain containing |
| ST8SIA3 protein network | https://string-db.org/network/9606.ENSP00000320431 | Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alp [...] |
| CTNNAL1 protein network | https://string-db.org/network/9606.ENSP00000320434 | Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1) |
| ARID1A protein network | https://string-db.org/network/9606.ENSP00000320485 | AT-rich interactive domain-containing protein 1A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component [...] |
| NAP1L5 protein network | https://string-db.org/network/9606.ENSP00000320488 | Nucleosome assembly protein 1 like 5 |
| EDC3 protein network | https://string-db.org/network/9606.ENSP00000320503 | Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping. May play a role in spermiogenesis an [...] |
| RNF185 protein network | https://string-db.org/network/9606.ENSP00000320508 | E3 ubiquitin-protein ligase RNF185; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic [...] |
| BANK1 protein network | https://string-db.org/network/9606.ENSP00000320509 | B-cell scaffold protein with ankyrin repeats; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and [...] |
| LRRC75B protein network | https://string-db.org/network/9606.ENSP00000320520 | Leucine-rich repeat-containing protein 75B; Leucine rich repeat containing 75B |
| FAM3A protein network | https://string-db.org/network/9606.ENSP00000320521 | Protein FAM3A; May act as a defensin against invading fungal microorganisms; Belongs to the FAM3 family |
| WFDC9 protein network | https://string-db.org/network/9606.ENSP00000320532 | Protein WFDC9; WAP four-disulfide core domain containing |
| EPN2 protein network | https://string-db.org/network/9606.ENSP00000320543 | Epsin-2; Plays a role in the formation of clathrin-coated invaginations and endocytosis |
| OR2D3 protein network | https://string-db.org/network/9606.ENSP00000320560 | Olfactory receptor 2D3; Odorant receptor; Olfactory receptors, family 2 |
| WDFY4 protein network | https://string-db.org/network/9606.ENSP00000320563 | WD repeat- and FYVE domain-containing protein 4; Armadillo-like helical domain containing |
| ING3 protein network | https://string-db.org/network/9606.ENSP00000320566 | Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleoso [...] |
| FAXDC2 protein network | https://string-db.org/network/9606.ENSP00000320604 | Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family |
| SLCO3A1 protein network | https://string-db.org/network/9606.ENSP00000320634 | Solute carrier organic anion transporter family member 3A1; Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate. Mediates transport of prostaglandins (PG) E1 and [...] |
| KIAA1875 protein network | https://string-db.org/network/9606.ENSP00000320648 | WD repeat-containing protein 97; KIAA1875 |
| CCDC89 protein network | https://string-db.org/network/9606.ENSP00000320649 | Coiled-coil domain containing 89; Belongs to the CCDC89 family |
| DNAJC25 protein network | https://string-db.org/network/9606.ENSP00000320650 | DnaJ heat shock protein family member C25; Belongs to the DNAJC25 family |
| YARS2 protein network | https://string-db.org/network/9606.ENSP00000320658 | Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acc [...] |
| EML4 protein network | https://string-db.org/network/9606.ENSP00000320663 | Echinoderm microtubule-associated protein-like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP fam [...] |
| STX19 protein network | https://string-db.org/network/9606.ENSP00000320679 | Syntaxin-19; Syntaxin 19; Belongs to the syntaxin family |
| SLC25A36 protein network | https://string-db.org/network/9606.ENSP00000320688 | Solute carrier family 25 member 36; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleosi [...] |
| TMEM150B protein network | https://string-db.org/network/9606.ENSP00000320757 | Modulator of macroautophagy TMEM150B; Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes [...] |
| KIAA2018 protein network | https://string-db.org/network/9606.ENSP00000320794 | Basic helix-loop-helix domain-containing protein USF3; Involved in the negative regulation of epithelial- mesenchymal transition, the process by which epithelial cells lose their polarity and adh [...] |
| TUBD1 protein network | https://string-db.org/network/9606.ENSP00000320797 | Tubulin delta chain; In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head; Tubulins |
| DEFB104A protein network | https://string-db.org/network/9606.ENSP00000320813 | Defensin, beta 104A; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Defensins, beta |
| GDPD4 protein network | https://string-db.org/network/9606.ENSP00000320815 | Glycerophosphodiester phosphodiesterase domain containing 4; Belongs to the glycerophosphoryl diester phosphodiesterase family |
| KIF1C protein network | https://string-db.org/network/9606.ENSP00000320821 | Kinesin-like protein KIF1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end- directed motility; Kinesins |
| CCDC184 protein network | https://string-db.org/network/9606.ENSP00000320849 | Coiled-coil domain containing 184 |
| CALR protein network | https://string-db.org/network/9606.ENSP00000320866 | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts [...] |
| TRIM41 protein network | https://string-db.org/network/9606.ENSP00000320869 | E3 ubiquitin-protein ligase TRIM41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C; Ring finger proteins |
| MLXIPL protein network | https://string-db.org/network/9606.ENSP00000320886 | Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity); Basic helix-loop-helix proteins |
| ASB8 protein network | https://string-db.org/network/9606.ENSP00000320893 | Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...] |
| RNF168 protein network | https://string-db.org/network/9606.ENSP00000320898 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ub [...] |
| KRI1 protein network | https://string-db.org/network/9606.ENSP00000320917 | KRI1 homolog; Belongs to the KRI1 family |
| WIPF2 protein network | https://string-db.org/network/9606.ENSP00000320924 | WAS/WASL-interacting protein family member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspik [...] |
| SLC2A4 protein network | https://string-db.org/network/9606.ENSP00000320935 | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter; Solute carriers |
| IL17RA protein network | https://string-db.org/network/9606.ENSP00000320936 | Interleukin-17 receptor A; Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17 [...] |
| CNOT1 protein network | https://string-db.org/network/9606.ENSP00000320949 | CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including [...] |
| DEFB103A protein network | https://string-db.org/network/9606.ENSP00000320951 | Defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multire [...] |
| VGLL2 protein network | https://string-db.org/network/9606.ENSP00000320957 | Transcription cofactor vestigial-like protein 2; May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles; Belongs to the vestigial family |
| CD300LG protein network | https://string-db.org/network/9606.ENSP00000321005 | CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity); V-set domain containing |
| C11orf42 protein network | https://string-db.org/network/9606.ENSP00000321021 | Uncharacterized protein C11orf42; Chromosome 11 open reading frame 42 |
| LURAP1L protein network | https://string-db.org/network/9606.ENSP00000321026 | Leucine rich adaptor protein 1 like |
| TMEM86B protein network | https://string-db.org/network/9606.ENSP00000321038 | Lysoplasmalogenase; Enzyme catalyzing the degradation of lysoplasmalogen. Lysoplasmalogens are formed by the hydrolysis of the abundant membrane glycerophospholipids plasmalogens. May control the [...] |
| ME2 protein network | https://string-db.org/network/9606.ENSP00000321070 | NAD-dependent malic enzyme, mitochondrial; Malic enzyme 2; Belongs to the malic enzymes family |
| SIGLEC8 protein network | https://string-db.org/network/9606.ENSP00000321077 | Sialic acid-binding Ig-like lectin 8; Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells. Preferentially binds to alpha-2,3-linked sialic acid. Also binds t [...] |
| TAC1 protein network | https://string-db.org/network/9606.ENSP00000321106 | Protachykinin-1; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth mus [...] |
| ZNF554 protein network | https://string-db.org/network/9606.ENSP00000321132 | Zinc finger protein 554; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RBM44 protein network | https://string-db.org/network/9606.ENSP00000321179 | RNA-binding protein 44; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for [...] |
| ATP11B protein network | https://string-db.org/network/9606.ENSP00000321195 | Probable phospholipid-transporting ATPase IF; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...] |
| OR56B4 protein network | https://string-db.org/network/9606.ENSP00000321196 | Olfactory receptor 56B4; Odorant receptor; Olfactory receptors, family 56 |
| TNIP2 protein network | https://string-db.org/network/9606.ENSP00000321203 | TNFAIP3-interacting protein 2; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appea [...] |
| SH2B1 protein network | https://string-db.org/network/9606.ENSP00000321221 | SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine ki [...] |
| RCHY1 protein network | https://string-db.org/network/9606.ENSP00000321239 | RING finger and CHY zinc finger domain-containing protein 1; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Prefer [...] |
| PRNT protein network | https://string-db.org/network/9606.ENSP00000321242 | Putative testis-specific prion protein; Prion locus lncRNA, testis expressed; Long non-coding RNAs |
| OR56A1 protein network | https://string-db.org/network/9606.ENSP00000321246 | Olfactory receptor 56A1; Odorant receptor; Olfactory receptors, family 56 |
| TALDO1 protein network | https://string-db.org/network/9606.ENSP00000321259 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway |
| COX8A protein network | https://string-db.org/network/9606.ENSP00000321260 | Cytochrome c oxidase subunit 8A, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| PITPNB protein network | https://string-db.org/network/9606.ENSP00000321266 | Phosphatidylinositol transfer protein beta isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes; Phosphatidylinositol transfer proteins |
| PXMP2 protein network | https://string-db.org/network/9606.ENSP00000321271 | Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane |
| VCX2 protein network | https://string-db.org/network/9606.ENSP00000321309 | Variable charge X-linked protein 2; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family |
| HGH1 protein network | https://string-db.org/network/9606.ENSP00000321320 | Protein HGH1 homolog; Armadillo-like helical domain containing; Belongs to the HGH1 family |
| F2R protein network | https://string-db.org/network/9606.ENSP00000321326 | Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vas [...] |
| RNF144A protein network | https://string-db.org/network/9606.ENSP00000321330 | E3 ubiquitin-protein ligase RNF144A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly trans [...] |
| LPA protein network | https://string-db.org/network/9606.ENSP00000321334 | Apolipoprotein(a); Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) [...] |
| OR4C5 protein network | https://string-db.org/network/9606.ENSP00000321338 | Olfactory receptor 4C5; Odorant receptor; Olfactory receptors, family 4 |
| ST8SIA5 protein network | https://string-db.org/network/9606.ENSP00000321343 | Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively; Belongs to the glycosyltransferase 29 family |
| IL23R protein network | https://string-db.org/network/9606.ENSP00000321345 | Interleukin-23 receptor; Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably [...] |
| TTLL11 protein network | https://string-db.org/network/9606.ENSP00000321346 | Tubulin polyglutamylase TTLL11; Polyglutamase which preferentially modifies alpha- tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiat [...] |
| DIAPH2 protein network | https://string-db.org/network/9606.ENSP00000321348 | Protein diaphanous homolog 2; Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are se [...] |
| C14orf177 protein network | https://string-db.org/network/9606.ENSP00000321360 | Putative uncharacterized protein C14orf177; Chromosome 14 open reading frame 177 |
| ZBED2 protein network | https://string-db.org/network/9606.ENSP00000321370 | Zinc finger BED-type containing 2 |
| FBXO39 protein network | https://string-db.org/network/9606.ENSP00000321386 | F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| ASB4 protein network | https://string-db.org/network/9606.ENSP00000321388 | Ankyrin repeat and SOCS box protein 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...] |
| OR4C3 protein network | https://string-db.org/network/9606.ENSP00000321419 | Olfactory receptor 4C3; Odorant receptor; Olfactory receptors, family 4 |
| SLC34A1 protein network | https://string-db.org/network/9606.ENSP00000321424 | Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the a [...] |
| OR52E4 protein network | https://string-db.org/network/9606.ENSP00000321426 | Olfactory receptor 52E4; Odorant receptor; Olfactory receptors, family 52 |
| KCNH5 protein network | https://string-db.org/network/9606.ENSP00000321427 | Potassium voltage-gated channel subfamily H member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties ma [...] |
| MSC protein network | https://string-db.org/network/9606.ENSP00000321445 | Musculin; Transcription repressor capable of inhibiting the transactivation capability of TCF3/E47. May play a role in regulating antigen-dependent B-cell differentiation; Basic helix-loop-helix [...] |
| OR4S1 protein network | https://string-db.org/network/9606.ENSP00000321447 | Olfactory receptor 4S1; Odorant receptor; Olfactory receptors, family 4 |
| RRP7A protein network | https://string-db.org/network/9606.ENSP00000321449 | Ribosomal RNA processing 7 homolog A; UTPc subcomplex |
| MICU3 protein network | https://string-db.org/network/9606.ENSP00000321455 | Calcium uptake protein 3, mitochondrial; May play a role in mitochondrial calcium uptake; EF-hand domain containing |
| C10orf67 protein network | https://string-db.org/network/9606.ENSP00000321464 | Uncharacterized protein C10orf67, mitochondrial; Chromosome 10 open reading frame 67 |
| KLHL38 protein network | https://string-db.org/network/9606.ENSP00000321475 | Kelch-like protein 38; Kelch like family member 38; BTB domain containing |
| SLC37A3 protein network | https://string-db.org/network/9606.ENSP00000321498 | Sugar phosphate exchanger 3; Solute carrier family 37 member 3 |
| OR4X1 protein network | https://string-db.org/network/9606.ENSP00000321506 | Olfactory receptor 4X1; Odorant receptor; Olfactory receptors, family 4 |
| C19orf18 protein network | https://string-db.org/network/9606.ENSP00000321519 | Uncharacterized protein C19orf18; Chromosome 19 open reading frame 18 |
| LLGL1 protein network | https://string-db.org/network/9606.ENSP00000321537 | Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic sp [...] |
| KBTBD11 protein network | https://string-db.org/network/9606.ENSP00000321544 | Kelch repeat and BTB domain containing 11 |
| LOH12CR1 protein network | https://string-db.org/network/9606.ENSP00000321546 | BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...] |
| DCBLD2 protein network | https://string-db.org/network/9606.ENSP00000321573 | Discoidin, CUB and LCCL domain containing 2 |
| IMPDH2 protein network | https://string-db.org/network/9606.ENSP00000321584 | Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synth [...] |
| CRMP1 protein network | https://string-db.org/network/9606.ENSP00000321606 | Dihydropyrimidinase-related protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migrat [...] |
| ANKZF1 protein network | https://string-db.org/network/9606.ENSP00000321617 | Ankyrin repeat and zinc finger domain-containing protein 1; Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellul [...] |
| ANKFN1 protein network | https://string-db.org/network/9606.ENSP00000321627 | Ankyrin repeat and fibronectin type III domain containing 1 |
| CDC25C protein network | https://string-db.org/network/9606.ENSP00000321656 | M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly eff [...] |
| ANKRD23 protein network | https://string-db.org/network/9606.ENSP00000321679 | Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression [...] |
| MEOX1 protein network | https://string-db.org/network/9606.ENSP00000321684 | Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome [...] |
| PDDC1 protein network | https://string-db.org/network/9606.ENSP00000321691 | Glutamine amidotransferase-like class 1 domain-containing protein 1; Parkinson disease 7 domain containing 1; Belongs to the peptidase C56 family |
| TACC1 protein network | https://string-db.org/network/9606.ENSP00000321703 | Transforming acidic coiled-coil-containing protein 1; Likely involved in the processes that promote cell division prior to the formation of differentiated tissues |
| GEMIN4 protein network | https://string-db.org/network/9606.ENSP00000321706 | Gem-associated protein 4; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...] |
| DIS3L protein network | https://string-db.org/network/9606.ENSP00000321711 | DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA proce [...] |
| OR51V1 protein network | https://string-db.org/network/9606.ENSP00000321729 | Olfactory receptor 51V1; Odorant receptor; Olfactory receptors, family 51 |
| SLC16A8 protein network | https://string-db.org/network/9606.ENSP00000321735 | Monocarboxylate transporter 3; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...] |
| HIST1H2BC protein network | https://string-db.org/network/9606.ENSP00000321744 | Histone cluster 1 H2B family member c; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| FGF8 protein network | https://string-db.org/network/9606.ENSP00000321797 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear an [...] |
| PAQR4 protein network | https://string-db.org/network/9606.ENSP00000321804 | Progestin and adipoQ receptor family member 4 |
| RIT2 protein network | https://string-db.org/network/9606.ENSP00000321805 | GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator; RAS type GTPase family |
| TRIT1 protein network | https://string-db.org/network/9606.ENSP00000321810 | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethyla [...] |
| ZNF776 protein network | https://string-db.org/network/9606.ENSP00000321812 | Zinc finger protein 776; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| STXBP5 protein network | https://string-db.org/network/9606.ENSP00000321826 | Syntaxin-binding protein 5; Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May [...] |
| ETV4 protein network | https://string-db.org/network/9606.ENSP00000321835 | ETS translocation variant 4; Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'; ETS transcription factor family |
| ZNF671 protein network | https://string-db.org/network/9606.ENSP00000321848 | Zinc finger protein 671; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SERPINF2 protein network | https://string-db.org/network/9606.ENSP00000321853 | Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin; Serpin peptidase inhibi [...] |
| CRELD1 protein network | https://string-db.org/network/9606.ENSP00000321856 | Cysteine rich with EGF like domains 1 |
| B3GNT3 protein network | https://string-db.org/network/9606.ENSP00000321874 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosacc [...] |
| FBXL13 protein network | https://string-db.org/network/9606.ENSP00000321927 | F-box/LRR-repeat protein 13; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; Cilia and flagella associated |
| FAIM2 protein network | https://string-db.org/network/9606.ENSP00000321951 | Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play [...] |
| FIBIN protein network | https://string-db.org/network/9606.ENSP00000321962 | Fin bud initiation factor homolog; Belongs to the FIBIN family |
| ZSCAN4 protein network | https://string-db.org/network/9606.ENSP00000321963 | Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic [...] |
| RHOT2 protein network | https://string-db.org/network/9606.ENSP00000321971 | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (B [...] |
| NKPD1 protein network | https://string-db.org/network/9606.ENSP00000321976 | NTPase KAP family P-loop domain containing 1 |
| TSPEAR protein network | https://string-db.org/network/9606.ENSP00000321987 | Thrombospondin-type laminin G domain and EAR repeat-containing protein; May play a role in development or function of the auditory system; Deafness associated genes |
| LARP1B protein network | https://string-db.org/network/9606.ENSP00000321997 | La-related protein 1B; La ribonucleoprotein domain family member 1B; Belongs to the LARP family |
| PTH1R protein network | https://string-db.org/network/9606.ENSP00000321999 | Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G prot [...] |
| SLC25A22 protein network | https://string-db.org/network/9606.ENSP00000322020 | Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Belongs to the mitochondrial carrier (TC 2 [...] |
| C7 protein network | https://string-db.org/network/9606.ENSP00000322061 | Complement component C7; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. [...] |
| OR52E2 protein network | https://string-db.org/network/9606.ENSP00000322088 | Olfactory receptor 52E2; Odorant receptor; Olfactory receptors, family 52 |
| ING5 protein network | https://string-db.org/network/9606.ENSP00000322142 | Inhibitor of growth protein 5; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of h [...] |
| OR51L1 protein network | https://string-db.org/network/9606.ENSP00000322156 | Olfactory receptor 51L1; Odorant receptor; Olfactory receptors, family 51 |
| ATG4C protein network | https://string-db.org/network/9606.ENSP00000322159 | Cysteine protease ATG4C; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Is not essential for autophagy development under normal conditions but is required [...] |
| PFN4 protein network | https://string-db.org/network/9606.ENSP00000322170 | Profilin-4; Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA) [...] |
| DSCC1 protein network | https://string-db.org/network/9606.ENSP00000322180 | Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid coh [...] |
| DPM2 protein network | https://string-db.org/network/9606.ENSP00000322181 | Dolichol phosphate-mannose biosynthesis regulatory protein; Regulates the biosynthesis of dolichol phosphate- mannose. Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; [...] |
| DEFB104B protein network | https://string-db.org/network/9606.ENSP00000322191 | Beta-defensin 104; Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103; Belongs to the beta-defensin family |
| PGA3 protein network | https://string-db.org/network/9606.ENSP00000322192 | Pepsin A-3; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent |
| PITPNM2 protein network | https://string-db.org/network/9606.ENSP00000322218 | Membrane-associated phosphatidylinositol transfer protein 2; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions |
| FADS1 protein network | https://string-db.org/network/9606.ENSP00000322229 | Fatty acid desaturase 1; Isoform 2 does not exhibit any catalytic activity toward 20:3n-6, but it may enhance FADS2 activity (By similarity). Isoform 1 is a component of a lipid metabolic pathway [...] |
| C14orf119 protein network | https://string-db.org/network/9606.ENSP00000322238 | Uncharacterized protein C14orf119; Chromosome 14 open reading frame 119 |
| RNF10 protein network | https://string-db.org/network/9606.ENSP00000322242 | RING finger protein 10; Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination; [...] |
| ORAI3 protein network | https://string-db.org/network/9606.ENSP00000322249 | Protein orai-3; Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import; Belongs to the Orai family |
| TNNI3K protein network | https://string-db.org/network/9606.ENSP00000322251 | Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily |
| ZNF620 protein network | https://string-db.org/network/9606.ENSP00000322265 | Zinc finger protein 620; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LPHN2 protein network | https://string-db.org/network/9606.ENSP00000322270 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exo [...] |
| OLFML3 protein network | https://string-db.org/network/9606.ENSP00000322273 | Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) a [...] |
| VNN2 protein network | https://string-db.org/network/9606.ENSP00000322276 | Vascular non-inflammatory molecule 2; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cystea [...] |
| TMTC2 protein network | https://string-db.org/network/9606.ENSP00000322300 | Transmembrane and tetratricopeptide repeat containing 2 |
| PORCN protein network | https://string-db.org/network/9606.ENSP00000322304 | Protein-serine O-palmitoleoyltransferase porcupine; Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, [...] |
| COQ7 protein network | https://string-db.org/network/9606.ENSP00000322316 | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural rol [...] |
| FAM20C protein network | https://string-db.org/network/9606.ENSP00000322323 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in bio [...] |
| VN1R1 protein network | https://string-db.org/network/9606.ENSP00000322339 | Vomeronasal type-1 receptor 1; Putative pheromone receptor; Belongs to the G-protein coupled receptor 1 family |
| CDK20 protein network | https://string-db.org/network/9606.ENSP00000322343 | Cyclin-dependent kinase 20; Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of th [...] |
| PLEKHF2 protein network | https://string-db.org/network/9606.ENSP00000322373 | Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellu [...] |
| FGF13 protein network | https://string-db.org/network/9606.ENSP00000322390 | Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, [...] |
| RRS1 protein network | https://string-db.org/network/9606.ENSP00000322396 | Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs t [...] |
| RPLP2 protein network | https://string-db.org/network/9606.ENSP00000322419 | 60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; L ribosomal proteins |
| HBA1 protein network | https://string-db.org/network/9606.ENSP00000322421 | Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family |
| OR6B3 protein network | https://string-db.org/network/9606.ENSP00000322435 | Olfactory receptor 6B3; Odorant receptor; Olfactory receptors, family 6 |
| TUFM protein network | https://string-db.org/network/9606.ENSP00000322439 | Elongation factor Tu, mitochondrial; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translat [...] |
| NDUFV1 protein network | https://string-db.org/network/9606.ENSP00000322450 | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minima [...] |
| SIAH2 protein network | https://string-db.org/network/9606.ENSP00000322457 | E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from a [...] |
| SCN4B protein network | https://string-db.org/network/9606.ENSP00000322460 | Sodium channel subunit beta-4; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage [...] |
| C3orf38 protein network | https://string-db.org/network/9606.ENSP00000322469 | Uncharacterized protein C3orf38; May be involved in apoptosis regulation |
| DCTPP1 protein network | https://string-db.org/network/9606.ENSP00000322524 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and [...] |
| PELI3 protein network | https://string-db.org/network/9606.ENSP00000322532 | E3 ubiquitin-protein ligase pellino homolog 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathway [...] |
| ZNF543 protein network | https://string-db.org/network/9606.ENSP00000322545 | Zinc finger protein 543; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR51G1 protein network | https://string-db.org/network/9606.ENSP00000322546 | Olfactory receptor 51G1; Odorant receptor; Olfactory receptors, family 51 |
| SOX11 protein network | https://string-db.org/network/9606.ENSP00000322568 | Transcription factor SOX-11; Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development; SRY-boxes |
| POLE protein network | https://string-db.org/network/9606.ENSP00000322570 | DNA polymerase epsilon catalytic subunit A; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase type-B family |
| PHF23 protein network | https://string-db.org/network/9606.ENSP00000322579 | PHD finger protein 23; Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvat [...] |
| C4orf17 protein network | https://string-db.org/network/9606.ENSP00000322582 | Uncharacterized protein C4orf17; Chromosome 4 open reading frame 17 |
| OR51G2 protein network | https://string-db.org/network/9606.ENSP00000322593 | Olfactory receptor 51G2; Odorant receptor; Olfactory receptors, family 51 |
| RAB39A protein network | https://string-db.org/network/9606.ENSP00000322594 | Ras-related protein Rab-39A; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Play [...] |
| ERICH3 protein network | https://string-db.org/network/9606.ENSP00000322609 | Glutamate-rich protein 3; Glutamate rich 3 |
| HTR3C protein network | https://string-db.org/network/9606.ENSP00000322617 | 5-hydroxytryptamine receptor 3C; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| ARL4D protein network | https://string-db.org/network/9606.ENSP00000322628 | ADP-ribosylation factor-like protein 4D; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...] |
| SPATA31E1 protein network | https://string-db.org/network/9606.ENSP00000322640 | Spermatogenesis-associated protein 31E1; May play a role in spermatogenesis |
| SLC25A41 protein network | https://string-db.org/network/9606.ENSP00000322649 | Solute carrier family 25 member 41; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| HMGCS1 protein network | https://string-db.org/network/9606.ENSP00000322706 | Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase |
| GLYR1 protein network | https://string-db.org/network/9606.ENSP00000322716 | Putative oxidoreductase GLYR1; Putative oxidoreductase that is recruited on chromatin and promotes KDM1B demethylase activity. Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) [...] |
| OR51H1P protein network | https://string-db.org/network/9606.ENSP00000322724 | Olfactory receptor 51H1; Odorant receptor |
| ITM2C protein network | https://string-db.org/network/9606.ENSP00000322730 | Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-sec [...] |
| OR51S1 protein network | https://string-db.org/network/9606.ENSP00000322754 | Olfactory receptor 51S1; Odorant receptor; Olfactory receptors, family 51 |
| RHBDF2 protein network | https://string-db.org/network/9606.ENSP00000322775 | Inactive rhomboid protein 2; Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activ [...] |
| OR5AK2 protein network | https://string-db.org/network/9606.ENSP00000322784 | Olfactory receptor 5AK2; Odorant receptor; Olfactory receptors, family 5 |
| MMP1 protein network | https://string-db.org/network/9606.ENSP00000322788 | Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves t [...] |
| OR52N2 protein network | https://string-db.org/network/9606.ENSP00000322801 | Olfactory receptor 52N2; Odorant receptor; Olfactory receptors, family 52 |
| TSPYL5 protein network | https://string-db.org/network/9606.ENSP00000322802 | Testis-specific Y-encoded-like protein 5; Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulati [...] |
| MTSS1 protein network | https://string-db.org/network/9606.ENSP00000322804 | Metastasis suppressor protein 1; May be related to cancer progression or tumor metastasis in a variety of organ sites, most likely through an interaction with the actin cytoskeleton; I-BAR domain [...] |
| OR52N1 protein network | https://string-db.org/network/9606.ENSP00000322823 | Olfactory receptor 52N1; Odorant receptor; Olfactory receptors, family 52 |
| ROGDI protein network | https://string-db.org/network/9606.ENSP00000322832 | Protein rogdi homolog; May act as a positive regulator of cell proliferation; Belongs to the rogdi family |
| TMEM40 protein network | https://string-db.org/network/9606.ENSP00000322837 | Transmembrane protein 40 |
| ZMYM3 protein network | https://string-db.org/network/9606.ENSP00000322845 | Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type |
| OR52N5 protein network | https://string-db.org/network/9606.ENSP00000322866 | Olfactory receptor 52N5; Odorant receptor; Olfactory receptors, family 52 |
| DTX2 protein network | https://string-db.org/network/9606.ENSP00000322885 | Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Prob [...] |
| EBF1 protein network | https://string-db.org/network/9606.ENSP00000322898 | Transcription factor COE1; Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' |
| ZNF843 protein network | https://string-db.org/network/9606.ENSP00000322899 | Zinc finger protein 843; Zinc fingers C2H2-type |
| ZMYM4 protein network | https://string-db.org/network/9606.ENSP00000322915 | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type |
| HTR1F protein network | https://string-db.org/network/9606.ENSP00000322924 | 5-hydroxytryptamine receptor 1F; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding cau [...] |
| LRSAM1 protein network | https://string-db.org/network/9606.ENSP00000322937 | E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF re [...] |
| OR56B1 protein network | https://string-db.org/network/9606.ENSP00000322939 | Olfactory receptor 56B1; Odorant receptor; Olfactory receptors, family 56 |
| MFAP3 protein network | https://string-db.org/network/9606.ENSP00000322956 | Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils; I-set domain containing |
| BCAT2 protein network | https://string-db.org/network/9606.ENSP00000322991 | Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also fun [...] |
| ACPP protein network | https://string-db.org/network/9606.ENSP00000323036 | Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphat [...] |
| EXOSC3 protein network | https://string-db.org/network/9606.ENSP00000323046 | Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| MTG1 protein network | https://string-db.org/network/9606.ENSP00000323047 | Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to [...] |
| GADD45GIP1 protein network | https://string-db.org/network/9606.ENSP00000323065 | Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effe [...] |
| TMEM168 protein network | https://string-db.org/network/9606.ENSP00000323068 | Transmembrane protein 168; Belongs to the TMEM168 family |
| ACOT4 protein network | https://string-db.org/network/9606.ENSP00000323071 | Acyl-coenzyme A thioesterase 4; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to r [...] |
| RAI1 protein network | https://string-db.org/network/9606.ENSP00000323074 | Retinoic acid-induced protein 1; Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transc [...] |
| NDUFAF3 protein network | https://string-db.org/network/9606.ENSP00000323076 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) |
| AMIGO3 protein network | https://string-db.org/network/9606.ENSP00000323096 | Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity); Immunoglobulin like domain co [...] |
| ATRIP protein network | https://string-db.org/network/9606.ENSP00000323099 | ATR-interacting protein; Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic init [...] |
| ZKSCAN1 protein network | https://string-db.org/network/9606.ENSP00000323148 | Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation; SCAN domain containing |
| DAND5 protein network | https://string-db.org/network/9606.ENSP00000323155 | DAN domain family member 5; Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important role [...] |
| ZBTB2 protein network | https://string-db.org/network/9606.ENSP00000323183 | Zinc finger and BTB domain-containing protein 2; May be involved in transcriptional regulation; BTB domain containing |
| MYCBPAP protein network | https://string-db.org/network/9606.ENSP00000323184 | MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity) |
| SAGE1 protein network | https://string-db.org/network/9606.ENSP00000323191 | Sarcoma antigen 1 |
| OR52N4 protein network | https://string-db.org/network/9606.ENSP00000323224 | Olfactory receptor 52N4; Odorant receptor; Olfactory receptors, family 52 |
| E2F7 protein network | https://string-db.org/network/9606.ENSP00000323246 | Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly act [...] |
| MARVELD2 protein network | https://string-db.org/network/9606.ENSP00000323264 | MARVEL domain-containing protein 2; Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another b [...] |
| DYX1C1 protein network | https://string-db.org/network/9606.ENSP00000323275 | Dynein assembly factor 4, axonemal; Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the st [...] |
| CD6 protein network | https://string-db.org/network/9606.ENSP00000323280 | T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades [...] |
| RPUSD2 protein network | https://string-db.org/network/9606.ENSP00000323288 | RNA pseudouridylate synthase domain containing 2 |
| SPAG5 protein network | https://string-db.org/network/9606.ENSP00000323300 | Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing o [...] |
| POC1B protein network | https://string-db.org/network/9606.ENSP00000323302 | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps [...] |
| LSMEM1 protein network | https://string-db.org/network/9606.ENSP00000323304 | Leucine rich single-pass membrane protein 1 |
| PDIA5 protein network | https://string-db.org/network/9606.ENSP00000323313 | Protein disulfide-isomerase A5; Protein disulfide isomerase family A member 5 |
| SIGLEC7 protein network | https://string-db.org/network/9606.ENSP00000323328 | Sialic acid-binding Ig-like lectin 7; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also bi [...] |
| ZNF645 protein network | https://string-db.org/network/9606.ENSP00000323348 | E3 ubiquitin-protein ligase ZNF645; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May operate on tyrosine-phosphorylated SRC substrates |
| OR5M8 protein network | https://string-db.org/network/9606.ENSP00000323354 | Olfactory receptor 5M8; Odorant receptor; Olfactory receptors, family 5 |
| FAM187B protein network | https://string-db.org/network/9606.ENSP00000323355 | Protein FAM187B; Family with sequence similarity 187 member B |
| SMC1A protein network | https://string-db.org/network/9606.ENSP00000323421 | Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for th [...] |
| OR2AP1 protein network | https://string-db.org/network/9606.ENSP00000323423 | Olfactory receptor 2AP1; Odorant receptor; Olfactory receptors, family 2 |
| ISG20L2 protein network | https://string-db.org/network/9606.ENSP00000323424 | Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containi [...] |
| SNX22 protein network | https://string-db.org/network/9606.ENSP00000323435 | Sorting nexin-22; May be involved in several stages of intracellular trafficking (By similarity). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)); Belongs to the [...] |
| TPRX1 protein network | https://string-db.org/network/9606.ENSP00000323455 | Tetra-peptide repeat homeobox protein 1; PRD class homeoboxes and pseudogenes |
| PNKP protein network | https://string-db.org/network/9606.ENSP00000323511 | Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) path [...] |
| UTS2R protein network | https://string-db.org/network/9606.ENSP00000323516 | Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messeng [...] |
| MKLN1 protein network | https://string-db.org/network/9606.ENSP00000323527 | Muskelin; Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1; CTLH complex |
| SLC6A18 protein network | https://string-db.org/network/9606.ENSP00000323549 | Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2. [...] |
| OR8K3 protein network | https://string-db.org/network/9606.ENSP00000323555 | Olfactory receptor 8K3; Odorant receptor; Olfactory receptors, family 8 |
| SLC2A2 protein network | https://string-db.org/network/9606.ENSP00000323568 | Solute carrier family 2, facilitated glucose transporter member 2; Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane [...] |
| IFT88 protein network | https://string-db.org/network/9606.ENSP00000323580 | Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic c [...] |
| TSHZ1 protein network | https://string-db.org/network/9606.ENSP00000323584 | Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential); Belongs to the teashirt C2H2-type zinc-finger prote [...] |
| ITLN1 protein network | https://string-db.org/network/9606.ENSP00000323587 | Intelectin-1; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, includin [...] |
| SOX2 protein network | https://string-db.org/network/9606.ENSP00000323588 | Transcription factor SOX-2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FG [...] |
| OR8H1 protein network | https://string-db.org/network/9606.ENSP00000323595 | Olfactory receptor 8H1; Odorant receptor; Olfactory receptors, family 8 |
| OR6C2 protein network | https://string-db.org/network/9606.ENSP00000323606 | Olfactory receptor 6C2; Odorant receptor; Olfactory receptors, family 6 |
| OR5T1 protein network | https://string-db.org/network/9606.ENSP00000323612 | Olfactory receptor 5T1; Odorant receptor; Olfactory receptors, family 5 |
| FAM210A protein network | https://string-db.org/network/9606.ENSP00000323635 | Protein FAM210A; Family with sequence similarity 210 member A; Belongs to the FAM210 family |
| TTC39C protein network | https://string-db.org/network/9606.ENSP00000323645 | Tetratricopeptide repeat domain containing |
| DBF4B protein network | https://string-db.org/network/9606.ENSP00000323663 | Protein DBF4 homolog B; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and [...] |
| ZBTB7A protein network | https://string-db.org/network/9606.ENSP00000323670 | Zinc finger and BTB domain-containing protein 7A; Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By si [...] |
| ZADH2 protein network | https://string-db.org/network/9606.ENSP00000323678 | Prostaglandin reductase 3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest efficienty towards 15-ket [...] |
| C15orf54 protein network | https://string-db.org/network/9606.ENSP00000323686 | Putative uncharacterized protein C15orf54; Chromosome 15 open reading frame 54 |
| UBE2O protein network | https://string-db.org/network/9606.ENSP00000323687 | (E3-independent) E2 ubiquitin-conjugating enzyme; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negative [...] |
| OR5T2 protein network | https://string-db.org/network/9606.ENSP00000323688 | Olfactory receptor 5T2; Odorant receptor; Olfactory receptors, family 5 |
| CRTAP protein network | https://string-db.org/network/9606.ENSP00000323696 | Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family |
| EIF4E1B protein network | https://string-db.org/network/9606.ENSP00000323714 | Eukaryotic translation initiation factor 4E type 1B; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates rib [...] |
| MED14 protein network | https://string-db.org/network/9606.ENSP00000323720 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| UCP3 protein network | https://string-db.org/network/9606.ENSP00000323740 | Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a re [...] |
| CCDC43 protein network | https://string-db.org/network/9606.ENSP00000323782 | Coiled-coil domain containing 43; Belongs to the CCDC43 family |
| TEX35 protein network | https://string-db.org/network/9606.ENSP00000323795 | Testis-expressed protein 35; Testis expressed 35 |
| PALM2 protein network | https://string-db.org/network/9606.ENSP00000323805 | Paralemmin-2; Paralemmin 2 |
| HACL1 protein network | https://string-db.org/network/9606.ENSP00000323811 | 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme fami [...] |
| AHRR protein network | https://string-db.org/network/9606.ENSP00000323816 | Aryl hydrocarbon receptor repressor; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this [...] |
| GVQW3 protein network | https://string-db.org/network/9606.ENSP00000323821 | annotation not available |
| ARL14 protein network | https://string-db.org/network/9606.ENSP00000323847 | ADP-ribosylation factor-like protein 14; GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along th [...] |
| OR8K5 protein network | https://string-db.org/network/9606.ENSP00000323853 | Olfactory receptor 8K5; Odorant receptor; Olfactory receptors, family 8 |
| PLEC protein network | https://string-db.org/network/9606.ENSP00000323856 | Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin t [...] |
| DDX54 protein network | https://string-db.org/network/9606.ENSP00000323858 | ATP-dependent RNA helicase DDX54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors; DEAD-box helicases |
| PRKAG1 protein network | https://string-db.org/network/9606.ENSP00000323867 | 5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...] |
| P2RY11 protein network | https://string-db.org/network/9606.ENSP00000323872 | Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP |
| ZNRF2 protein network | https://string-db.org/network/9606.ENSP00000323879 | E3 ubiquitin-protein ligase ZNRF2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiq [...] |
| FOXJ1 protein network | https://string-db.org/network/9606.ENSP00000323880 | Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFA [...] |
| TRIM25 protein network | https://string-db.org/network/9606.ENSP00000323889 | E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'L [...] |
| OR10D3 protein network | https://string-db.org/network/9606.ENSP00000323895 | Putative olfactory receptor 10D3; Odorant receptor; Olfactory receptors, family 10 |
| FZD2 protein network | https://string-db.org/network/9606.ENSP00000323901 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| TRIM55 protein network | https://string-db.org/network/9606.ENSP00000323913 | Tripartite motif-containing protein 55; May regulate gene expression and protein turnover in muscle cells; Ring finger proteins |
| TRPM8 protein network | https://string-db.org/network/9606.ENSP00000323926 | Transient receptor potential cation channel subfamily M member 8; Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold [...] |
| PLXDC1 protein network | https://string-db.org/network/9606.ENSP00000323927 | Plexin domain-containing protein 1; Plays a critical role in endothelial cell capillary morphogenesis |
| OR8H3 protein network | https://string-db.org/network/9606.ENSP00000323928 | Olfactory receptor 8H3; Odorant receptor; Olfactory receptors, family 8 |
| A2M protein network | https://string-db.org/network/9606.ENSP00000323929 | Alpha-2-macroglobulin; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cl [...] |
| ZNF771 protein network | https://string-db.org/network/9606.ENSP00000323945 | Zinc finger protein 771; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR51F2 protein network | https://string-db.org/network/9606.ENSP00000323952 | Olfactory receptor 51F2; Odorant receptor; Olfactory receptors, family 51 |
| SMARCE1 protein network | https://string-db.org/network/9606.ENSP00000323967 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...] |
| CRIPAK protein network | https://string-db.org/network/9606.ENSP00000323978 | Cysteine-rich PAK1 inhibitor; Negative regulator of PAK1. It has been suggested that the lost of CRIPAK in breast tumors might contribute to hormonal independence |
| OR8H2 protein network | https://string-db.org/network/9606.ENSP00000323982 | Olfactory receptor 8H2; Odorant receptor; Olfactory receptors, family 8 |
| KIF15 protein network | https://string-db.org/network/9606.ENSP00000324020 | Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 s [...] |
| ZNF354C protein network | https://string-db.org/network/9606.ENSP00000324064 | Zinc finger protein 354C; May function as a transcription repressor. Binds to 5'- CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation ( [...] |
| ENO3 protein network | https://string-db.org/network/9606.ENSP00000324105 | Beta-enolase; Appears to have a function in striated muscle development and regeneration; Belongs to the enolase family |
| OR5AS1 protein network | https://string-db.org/network/9606.ENSP00000324111 | Olfactory receptor 5AS1; Odorant receptor; Olfactory receptors, family 5 |
| PRPF31 protein network | https://string-db.org/network/9606.ENSP00000324122 | U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small [...] |
| POLR2L protein network | https://string-db.org/network/9606.ENSP00000324124 | DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...] |
| PSD3 protein network | https://string-db.org/network/9606.ENSP00000324127 | PH and SEC7 domain-containing protein 3; Guanine nucleotide exchange factor for ARF6; Pleckstrin homology domain containing |
| HSPA5 protein network | https://string-db.org/network/9606.ENSP00000324173 | 78 kDa glucose-regulated protein; Plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degra [...] |
| MAMSTR protein network | https://string-db.org/network/9606.ENSP00000324175 | MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF [...] |
| KCNRG protein network | https://string-db.org/network/9606.ENSP00000324191 | Potassium channel regulatory protein; Inhibits potassium fluxes in cells. May regulate Kv1 family channel proteins by retaining a fraction of channels in endomembranes |
| AATK protein network | https://string-db.org/network/9606.ENSP00000324196 | Serine/threonine-protein kinase LMTK1; May be involved in neuronal differentiation; Protein phosphatase 1 regulatory subunits |
| WRAP53 protein network | https://string-db.org/network/9606.ENSP00000324203 | Telomerase Cajal body protein 1; Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres [...] |
| MTURN protein network | https://string-db.org/network/9606.ENSP00000324204 | Maturin; May be involved in early neuronal development |
| CHMP4A protein network | https://string-db.org/network/9606.ENSP00000324205 | Charged multivesicular body protein 4a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| PENK protein network | https://string-db.org/network/9606.ENSP00000324248 | Proenkephalin-A; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to str [...] |
| OR10K2 protein network | https://string-db.org/network/9606.ENSP00000324251 | Olfactory receptor 10K2; Odorant receptor; Olfactory receptors, family 10 |
| OXTR protein network | https://string-db.org/network/9606.ENSP00000324270 | Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol- calcium second messenger system; Arginine vasopressin and [...] |
| APOLD1 protein network | https://string-db.org/network/9606.ENSP00000324277 | Apolipoprotein L domain-containing protein 1; May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood- brain permeability |
| ACAP2 protein network | https://string-db.org/network/9606.ENSP00000324287 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6); Ankyrin repeat domain containing |
| FBF1 protein network | https://string-db.org/network/9606.ENSP00000324292 | Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenes [...] |
| STXBP6 protein network | https://string-db.org/network/9606.ENSP00000324302 | Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis |
| TRAPPC12 protein network | https://string-db.org/network/9606.ENSP00000324318 | Trafficking protein particle complex subunit 12; Plays an important role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores. M [...] |
| TCTEX1D2 protein network | https://string-db.org/network/9606.ENSP00000324323 | Tctex1 domain-containing protein 2; Required for proper retrograde ciliary transport; Belongs to the dynein light chain Tctex-type family |
| UPB1 protein network | https://string-db.org/network/9606.ENSP00000324343 | Beta-ureidopropionase; Converts N-carbamoyl-beta-aminoisobutyrate and N- carbamoyl-beta-alanine (3-ureidopropanoate) to, respectively, beta-aminoisobutyrate and beta-alanine, ammonia and carbon d [...] |
| OR2T35 protein network | https://string-db.org/network/9606.ENSP00000324369 | Olfactory receptor 2T35; Odorant receptor; Olfactory receptors, family 2 |
| PHF21B protein network | https://string-db.org/network/9606.ENSP00000324403 | PHD finger protein 21B |
| TCHP protein network | https://string-db.org/network/9606.ENSP00000324404 | Trichoplein keratin filament-binding protein; Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate c [...] |
| SYT9 protein network | https://string-db.org/network/9606.ENSP00000324419 | Synaptotagmin-9; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...] |
| ZYX protein network | https://string-db.org/network/9606.ENSP00000324422 | Zyxin; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. [...] |
| YLPM1 protein network | https://string-db.org/network/9606.ENSP00000324463 | YLP motif-containing protein 1; Plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its dow [...] |
| CSNK1D protein network | https://string-db.org/network/9606.ENSP00000324464 | Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. I [...] |
| BAIAP3 protein network | https://string-db.org/network/9606.ENSP00000324510 | BAI1 associated protein 3; C2 domain containing |
| SEPT1 protein network | https://string-db.org/network/9606.ENSP00000324511 | Septin-1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin [...] |
| MYO1D protein network | https://string-db.org/network/9606.ENSP00000324527 | Unconventional myosin-Id; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| LAMA3 protein network | https://string-db.org/network/9606.ENSP00000324532 | Laminin subunit alpha-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| OR14C36 protein network | https://string-db.org/network/9606.ENSP00000324534 | Olfactory receptor 14C36; Odorant receptor; Olfactory receptors, family 14 |
| OR2M7 protein network | https://string-db.org/network/9606.ENSP00000324557 | Olfactory receptor 2M7; Odorant receptor; Olfactory receptors, family 2 |
| ULK1 protein network | https://string-db.org/network/9606.ENSP00000324560 | Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the forma [...] |
| FLII protein network | https://string-db.org/network/9606.ENSP00000324573 | Protein flightless-1 homolog; May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in es [...] |
| OR2T12 protein network | https://string-db.org/network/9606.ENSP00000324583 | Olfactory receptor 2T12; Odorant receptor; Olfactory receptors, family 2 |
| FAM193A protein network | https://string-db.org/network/9606.ENSP00000324587 | Protein FAM193A; Family with sequence similarity 193 member A |
| ZNF660 protein network | https://string-db.org/network/9606.ENSP00000324605 | Zinc finger protein 660; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NAPG protein network | https://string-db.org/network/9606.ENSP00000324628 | Gamma-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family |
| DEFB103B protein network | https://string-db.org/network/9606.ENSP00000324633 | Beta-defensin 103; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresi [...] |
| CYP2B6 protein network | https://string-db.org/network/9606.ENSP00000324648 | Cytochrome P450 2B6; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| TMEM108 protein network | https://string-db.org/network/9606.ENSP00000324651 | Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is neccessary for AMPA receptors surf [...] |
| C16orf89 protein network | https://string-db.org/network/9606.ENSP00000324672 | UPF0764 protein C16orf89; Chromosome 16 open reading frame 89 |
| OR2T33 protein network | https://string-db.org/network/9606.ENSP00000324687 | Olfactory receptor 2T33; Odorant receptor; Olfactory receptors, family 2 |
| GRHL1 protein network | https://string-db.org/network/9606.ENSP00000324693 | Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context [...] |
| MAB21L2 protein network | https://string-db.org/network/9606.ENSP00000324701 | Protein mab-21-like 2; Required for several aspects of embryonic development including normal development of the eye; Belongs to the mab-21 family |
| SAV1 protein network | https://string-db.org/network/9606.ENSP00000324729 | Protein salvador homolog 1; Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...] |
| C7orf43 protein network | https://string-db.org/network/9606.ENSP00000324741 | Uncharacterized protein C7orf43; Chromosome 7 open reading frame 43 |
| WFIKKN1 protein network | https://string-db.org/network/9606.ENSP00000324763 | WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metallopro [...] |
| OR4C6 protein network | https://string-db.org/network/9606.ENSP00000324769 | Olfactory receptor 4C6; Odorant receptor; Olfactory receptors, family 4 |
| TMIE protein network | https://string-db.org/network/9606.ENSP00000324775 | Transmembrane inner ear expressed protein; Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways suc [...] |
| NFATC2IP protein network | https://string-db.org/network/9606.ENSP00000324792 | NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. [...] |
| TMEM78 protein network | https://string-db.org/network/9606.ENSP00000324799 | Transmembrane protein 78 |
| PPP2R1A protein network | https://string-db.org/network/9606.ENSP00000324804 | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the ca [...] |
| GSK3B protein network | https://string-db.org/network/9606.ENSP00000324806 | Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcripti [...] |
| MVB12A protein network | https://string-db.org/network/9606.ENSP00000324810 | Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bod [...] |
| AKAP17A protein network | https://string-db.org/network/9606.ENSP00000324827 | A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner; A-kinase [...] |
| OR4P4 protein network | https://string-db.org/network/9606.ENSP00000324831 | Olfactory receptor 4P4; Odorant receptor; Olfactory receptors, family 4 |
| AACS protein network | https://string-db.org/network/9606.ENSP00000324842 | Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity); Bel [...] |
| STK11 protein network | https://string-db.org/network/9606.ENSP00000324856 | Serine/threonine-protein kinase STK11; Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in [...] |
| SEMA6D protein network | https://string-db.org/network/9606.ENSP00000324857 | Semaphorin-6D; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other ne [...] |
| SPINK6 protein network | https://string-db.org/network/9606.ENSP00000324870 | Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit KLK8; Serine pept [...] |
| CD28 protein network | https://string-db.org/network/9606.ENSP00000324890 | T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of [...] |
| IQCK protein network | https://string-db.org/network/9606.ENSP00000324901 | IQ motif containing K |
| OR4C16 protein network | https://string-db.org/network/9606.ENSP00000324913 | Olfactory receptor 4C16; Odorant receptor; Olfactory receptors, family 4 |
| C14orf39 protein network | https://string-db.org/network/9606.ENSP00000324920 | Protein SIX6OS1; Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropria [...] |
| MBOAT1 protein network | https://string-db.org/network/9606.ENSP00000324944 | Lysophospholipid acyltransferase 1; Acyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-d [...] |
| OR4C15 protein network | https://string-db.org/network/9606.ENSP00000324958 | Olfactory receptor 4C15; Odorant receptor; Olfactory receptors, family 4 |
| CABP4 protein network | https://string-db.org/network/9606.ENSP00000324960 | Calcium-binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. [...] |
| COPG1 protein network | https://string-db.org/network/9606.ENSP00000325002 | Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosy [...] |
| NCAPD2 protein network | https://string-db.org/network/9606.ENSP00000325017 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex p [...] |
| ZNF569 protein network | https://string-db.org/network/9606.ENSP00000325018 | Zinc finger protein 569; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| OR4A15 protein network | https://string-db.org/network/9606.ENSP00000325065 | Olfactory receptor 4A15; Odorant receptor; Olfactory receptors, family 4 |
| PPP2R2A protein network | https://string-db.org/network/9606.ENSP00000325074 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...] |
| OR10G4 protein network | https://string-db.org/network/9606.ENSP00000325076 | Olfactory receptor 10G4; Odorant receptor; Olfactory receptors, family 10 |
| OR2AJ1 protein network | https://string-db.org/network/9606.ENSP00000325078 | Olfactory receptor 2AJ1; Odorant receptor; Olfactory receptors, family 2 |
| LRCH2 protein network | https://string-db.org/network/9606.ENSP00000325091 | Leucine rich repeats and calponin homology domain containing 2 |
| PGR protein network | https://string-db.org/network/9606.ENSP00000325120 | Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissue [...] |
| OR4A16 protein network | https://string-db.org/network/9606.ENSP00000325128 | Olfactory receptor 4A16; Odorant receptor; Olfactory receptors, family 4 |
| HADHB protein network | https://string-db.org/network/9606.ENSP00000325136 | hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta |
| C15orf53 protein network | https://string-db.org/network/9606.ENSP00000325144 | Uncharacterized protein C15orf53; Chromosome 15 open reading frame 53 |
| COL12A1 protein network | https://string-db.org/network/9606.ENSP00000325146 | Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domain [...] |
| OR6T1 protein network | https://string-db.org/network/9606.ENSP00000325203 | Olfactory receptor 6T1; Odorant receptor; Olfactory receptors, family 6 |
| MYLPF protein network | https://string-db.org/network/9606.ENSP00000325239 | Myosin light chain, phosphorylatable, fast skeletal muscle; EF-hand domain containing |
| LASP1 protein network | https://string-db.org/network/9606.ENSP00000325240 | LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regul [...] |
| TTC9C protein network | https://string-db.org/network/9606.ENSP00000325266 | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family |
| MTMR4 protein network | https://string-db.org/network/9606.ENSP00000325285 | Myotubularin-related protein 4; Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates pho [...] |
| GSG2 protein network | https://string-db.org/network/9606.ENSP00000325290 | Serine/threonine-protein kinase haspin; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate act [...] |
| PKD2L1 protein network | https://string-db.org/network/9606.ENSP00000325296 | Polycystic kidney disease 2-like 1 protein; Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concen [...] |
| CDPF1 protein network | https://string-db.org/network/9606.ENSP00000325301 | Cysteine rich DPF motif domain containing 1 |
| METAP2 protein network | https://string-db.org/network/9606.ENSP00000325312 | Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence [...] |
| MAP1S protein network | https://string-db.org/network/9606.ENSP00000325313 | Microtubule-associated protein 1S; Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the m [...] |
| ZNF335 protein network | https://string-db.org/network/9606.ENSP00000325326 | Zinc finger protein 335; Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhance [...] |
| CASKIN2 protein network | https://string-db.org/network/9606.ENSP00000325355 | Caskin-2; Sterile alpha motif domain containing |
| AP3S1 protein network | https://string-db.org/network/9606.ENSP00000325369 | AP-3 complex subunit sigma-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...] |
| HNRNPM protein network | https://string-db.org/network/9606.ENSP00000325376 | Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoemb [...] |
| WDR33 protein network | https://string-db.org/network/9606.ENSP00000325377 | pre-mRNA 3' end processing protein WDR33; Essential for both cleavage and polyadenylation of pre- mRNA 3' ends; WD repeat domain containing |
| OR8D4 protein network | https://string-db.org/network/9606.ENSP00000325381 | Olfactory receptor 8D4; Odorant receptor; Olfactory receptors, family 8 |
| MYPOP protein network | https://string-db.org/network/9606.ENSP00000325402 | Myb-related transcription factor, partner of profilin; Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduce [...] |
| SERTAD3 protein network | https://string-db.org/network/9606.ENSP00000325414 | SERTA domain-containing protein 3; Strong transcriptional coactivator |
| PARL protein network | https://string-db.org/network/9606.ENSP00000325421 | Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 w [...] |
| MAT2B protein network | https://string-db.org/network/9606.ENSP00000325425 | Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Reg [...] |
| KARS protein network | https://string-db.org/network/9606.ENSP00000325448 | Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred [...] |
| CERS5 protein network | https://string-db.org/network/9606.ENSP00000325485 | Ceramide synthase 5; Dihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. I [...] |
| C11orf71 protein network | https://string-db.org/network/9606.ENSP00000325508 | Uncharacterized protein C11orf71; Chromosome 11 open reading frame 71 |
| KIR3DL2 protein network | https://string-db.org/network/9606.ENSP00000325525 | Killer cell immunoglobulin-like receptor 3DL2; Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules |
| WNT11 protein network | https://string-db.org/network/9606.ENSP00000325526 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| FBN1 protein network | https://string-db.org/network/9606.ENSP00000325527 | Fibrillin-1; Fibrillin-1: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connectiv [...] |
| PLAG1 protein network | https://string-db.org/network/9606.ENSP00000325546 | Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultur [...] |
| CNDP2 protein network | https://string-db.org/network/9606.ENSP00000325548 | Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Acts as a functional tumor suppressor in gastric cancer via a [...] |
| TMC8 protein network | https://string-db.org/network/9606.ENSP00000325561 | Transmembrane channel-like protein 8; Probable ion channel; Transmembrane channel likes |
| MINOS1 protein network | https://string-db.org/network/9606.ENSP00000325562 | MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| SYCN protein network | https://string-db.org/network/9606.ENSP00000325564 | Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in o [...] |
| PTPRCAP protein network | https://string-db.org/network/9606.ENSP00000325589 | Protein tyrosine phosphatase, receptor type C associated protein |
| RUFY1 protein network | https://string-db.org/network/9606.ENSP00000325594 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type |
| MED16 protein network | https://string-db.org/network/9606.ENSP00000325612 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| PARP10 protein network | https://string-db.org/network/9606.ENSP00000325618 | Poly [ADP-ribose] polymerase 10; May play a role in cell proliferation. May be required for the maintenance of cell cycle progression; Poly(ADP-ribose) polymerases |
| ZNF639 protein network | https://string-db.org/network/9606.ENSP00000325634 | Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PRM3 protein network | https://string-db.org/network/9606.ENSP00000325638 | Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex [...] |
| CHCHD5 protein network | https://string-db.org/network/9606.ENSP00000325655 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins |
| NFKBIZ protein network | https://string-db.org/network/9606.ENSP00000325663 | NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits [...] |
| EXOC3L1 protein network | https://string-db.org/network/9606.ENSP00000325674 | Exocyst complex component 3-like protein; As part of the exocyst, may play a role in regulated exocytosis of insulin granules |
| RNF40 protein network | https://string-db.org/network/9606.ENSP00000325677 | E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a spec [...] |
| CCZ1 protein network | https://string-db.org/network/9606.ENSP00000325681 | CCZ1 homolog, vacuolar protein trafficking and biogenesis associated |
| OR2B11 protein network | https://string-db.org/network/9606.ENSP00000325682 | Olfactory receptor 2B11; Odorant receptor; Olfactory receptors, family 2 |
| CARM1 protein network | https://string-db.org/network/9606.ENSP00000325690 | Histone-arginine methyltransferase CARM1; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription [...] |
| CD37 protein network | https://string-db.org/network/9606.ENSP00000325708 | Leukocyte antigen CD37; CD37 molecule |
| TNP2 protein network | https://string-db.org/network/9606.ENSP00000325738 | Nuclear transition protein 2; Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it [...] |
| STK25 protein network | https://string-db.org/network/9606.ENSP00000325748 | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears [...] |
| GJC3 protein network | https://string-db.org/network/9606.ENSP00000325775 | Gap junction gamma-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| SERTM1 protein network | https://string-db.org/network/9606.ENSP00000325776 | Serine rich and transmembrane domain containing 1 |
| SPECC1L protein network | https://string-db.org/network/9606.ENSP00000325785 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migr [...] |
| LRRN4CL protein network | https://string-db.org/network/9606.ENSP00000325808 | LRRN4 C-terminal-like protein; Fibronectin type III domain containing |
| NR2F1 protein network | https://string-db.org/network/9606.ENSP00000325819 | COUP transcription factor 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiati [...] |
| CYP11B2 protein network | https://string-db.org/network/9606.ENSP00000325822 | Cytochrome P450 11B2, mitochondrial; Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone; Belongs to the cytochrome [...] |
| SEC16A protein network | https://string-db.org/network/9606.ENSP00000325827 | Protein transport protein Sec16A; Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-depe [...] |
| DIRAS1 protein network | https://string-db.org/network/9606.ENSP00000325836 | GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; RAS type GTPase family |
| MRE11A protein network | https://string-db.org/network/9606.ENSP00000325863 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and me [...] |
| ODF3 protein network | https://string-db.org/network/9606.ENSP00000325868 | Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maint [...] |
| ANKDD1A protein network | https://string-db.org/network/9606.ENSP00000325895 | Ankyrin repeat and death domain containing 1A |
| SRSF7 protein network | https://string-db.org/network/9606.ENSP00000325905 | Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter [...] |
| PCSK7 protein network | https://string-db.org/network/9606.ENSP00000325917 | Proprotein convertase subtilisin/kexin type 7; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...] |
| PSMG2 protein network | https://string-db.org/network/9606.ENSP00000325919 | Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 prot [...] |
| LNX2 protein network | https://string-db.org/network/9606.ENSP00000325929 | Ligand of numb-protein X 2; PDZ domain containing |
| RIC8A protein network | https://string-db.org/network/9606.ENSP00000325941 | Synembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for fre [...] |
| CDHR3 protein network | https://string-db.org/network/9606.ENSP00000325954 | Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may th [...] |
| PTPMT1 protein network | https://string-db.org/network/9606.ENSP00000325958 | Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential in [...] |
| LRRC31 protein network | https://string-db.org/network/9606.ENSP00000325978 | Leucine-rich repeat-containing protein 31; Leucine rich repeat containing 31 |
| PUS10 protein network | https://string-db.org/network/9606.ENSP00000326003 | Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formatio [...] |
| PRX protein network | https://string-db.org/network/9606.ENSP00000326018 | Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the mainte [...] |
| FHL5 protein network | https://string-db.org/network/9606.ENSP00000326022 | Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner; LIM domain containi [...] |
| PPP1CA protein network | https://string-db.org/network/9606.ENSP00000326031 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate h [...] |
| TUBA3D protein network | https://string-db.org/network/9606.ENSP00000326042 | Tubulin, alpha 3d; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain [...] |
| TMEM39A protein network | https://string-db.org/network/9606.ENSP00000326063 | Transmembrane protein 39A; Belongs to the TMEM39 family |
| SLC41A3 protein network | https://string-db.org/network/9606.ENSP00000326070 | Solute carrier family 41 member 3 |
| RNF166 protein network | https://string-db.org/network/9606.ENSP00000326095 | E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates . In turn, participates in different biological processes including interferon production or autophagy . Plays [...] |
| C5orf30 protein network | https://string-db.org/network/9606.ENSP00000326110 | UNC119-binding protein C5orf30; Probably plays a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or th [...] |
| PMAIP1 protein network | https://string-db.org/network/9606.ENSP00000326119 | Phorbol-12-myristate-13-acetate-induced protein 1; Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. [...] |
| KLK4 protein network | https://string-db.org/network/9606.ENSP00000326159 | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline [...] |
| RFFL protein network | https://string-db.org/network/9606.ENSP00000326170 | E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. M [...] |
| ZBTB11 protein network | https://string-db.org/network/9606.ENSP00000326200 | Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation; BTB domain containing |
| DHRS4 protein network | https://string-db.org/network/9606.ENSP00000326219 | Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficie [...] |
| OR2T8 protein network | https://string-db.org/network/9606.ENSP00000326225 | Olfactory receptor 2T8; Odorant receptor; Olfactory receptors, family 2 |
| GANC protein network | https://string-db.org/network/9606.ENSP00000326227 | Neutral alpha-glucosidase C; Has alpha-glucosidase activity |
| OR52D1 protein network | https://string-db.org/network/9606.ENSP00000326232 | Olfactory receptor 52D1; Odorant receptor; Olfactory receptors, family 52 |
| CAPZA3 protein network | https://string-db.org/network/9606.ENSP00000326238 | F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...] |
| MYNN protein network | https://string-db.org/network/9606.ENSP00000326240 | Myoneurin; Zinc fingers C2H2-type; BTB domain containing |
| TMEM151A protein network | https://string-db.org/network/9606.ENSP00000326244 | Transmembrane protein 151A |
| SAMD9L protein network | https://string-db.org/network/9606.ENSP00000326247 | Sterile alpha motif domain-containing protein 9-like; May be involved in endosome fusion. Mediates down- regulation of growth factor signaling via internalization of growth factor receptors; Ster [...] |
| ZNF454 protein network | https://string-db.org/network/9606.ENSP00000326249 | Zinc finger protein 454; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RTBDN protein network | https://string-db.org/network/9606.ENSP00000326253 | Retbindin; Riboflavin-binding protein which might have a role in retinal flavin transport |
| OR52H1 protein network | https://string-db.org/network/9606.ENSP00000326259 | Olfactory receptor 52H1; Odorant receptor; Olfactory receptors, family 52 |
| SRRM1 protein network | https://string-db.org/network/9606.ENSP00000326261 | Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing [...] |
| EFCAB11 protein network | https://string-db.org/network/9606.ENSP00000326267 | EF-hand calcium-binding domain-containing protein 11; EF-hand calcium binding domain 11 |
| FOXL1 protein network | https://string-db.org/network/9606.ENSP00000326272 | Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 [...] |
| OR2G3 protein network | https://string-db.org/network/9606.ENSP00000326301 | Olfactory receptor 2G3; Odorant receptor; Olfactory receptors, family 2 |
| SLC25A20 protein network | https://string-db.org/network/9606.ENSP00000326305 | Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial m [...] |
| DEFB124 protein network | https://string-db.org/network/9606.ENSP00000326309 | Beta-defensin 124; Has antibacterial activity; Defensins, beta |
| LRRC37A protein network | https://string-db.org/network/9606.ENSP00000326324 | Leucine-rich repeat-containing protein 37A; Leucine rich repeat containing 37A |
| FRAS1 protein network | https://string-db.org/network/9606.ENSP00000326330 | Fraser extracellular matrix complex subunit 1 |
| ATG16L2 protein network | https://string-db.org/network/9606.ENSP00000326340 | Autophagy-related protein 16-2; May play a role in autophagy |
| ELMOD2 protein network | https://string-db.org/network/9606.ENSP00000326342 | ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. [...] |
| OR2G2 protein network | https://string-db.org/network/9606.ENSP00000326349 | Olfactory receptor 2G2; Odorant receptor; Olfactory receptors, family 2 |
| PSEN1 protein network | https://string-db.org/network/9606.ENSP00000326366 | Presenilin-1; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (am [...] |
| FOXC2 protein network | https://string-db.org/network/9606.ENSP00000326371 | Forkhead box protein C2; Transcriptional activator. Might be involved in the formation of special mesenchymal tissues; Forkhead boxes |
| EIF4A2 protein network | https://string-db.org/network/9606.ENSP00000326381 | Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current mod [...] |
| CLEC1A protein network | https://string-db.org/network/9606.ENSP00000326407 | C-type lectin domain family 1 member A |
| CWF19L1 protein network | https://string-db.org/network/9606.ENSP00000326411 | CWF19-like protein 1; CWF19 like 1, cell cycle control |
| NADSYN1 protein network | https://string-db.org/network/9606.ENSP00000326424 | Glutamine-dependent NAD(+) synthetase; NAD synthetase 1; In the C-terminal section; belongs to the NAD synthetase family |
| CCR8 protein network | https://string-db.org/network/9606.ENSP00000326432 | C-C chemokine receptor type 8; Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection; C [...] |
| SHISA3 protein network | https://string-db.org/network/9606.ENSP00000326445 | Protein shisa-3 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling; Shisa family members |
| ABHD1 protein network | https://string-db.org/network/9606.ENSP00000326491 | Protein ABHD1; Abhydrolase domain containing 1; Belongs to the AB hydrolase superfamily. AB hydrolase 4 family |
| PA1 protein network | https://string-db.org/network/9606.ENSP00000326519 | PAXIP1 associated glutamate rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in associa [...] |
| THOC6 protein network | https://string-db.org/network/9606.ENSP00000326531 | THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically ass [...] |
| TACC3 protein network | https://string-db.org/network/9606.ENSP00000326550 | Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-medi [...] |
| KDM3B protein network | https://string-db.org/network/9606.ENSP00000326563 | Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates f [...] |
| FKRP protein network | https://string-db.org/network/9606.ENSP00000326570 | Fukutin-related protein; Transferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine- beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), [...] |
| HCCS protein network | https://string-db.org/network/9606.ENSP00000326579 | Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c |
| PEG3 protein network | https://string-db.org/network/9606.ENSP00000326581 | Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts sy [...] |
| SMCHD1 protein network | https://string-db.org/network/9606.ENSP00000326603 | Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactiv [...] |
| LMBR1 protein network | https://string-db.org/network/9606.ENSP00000326604 | Limb region 1 protein homolog; Putative membrane receptor |
| ASIC4 protein network | https://string-db.org/network/9606.ENSP00000326627 | Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium. In vitro, has no proton-gated channel activity; Acid sensing ion channel subunits |
| ZFPM1 protein network | https://string-db.org/network/9606.ENSP00000326630 | Zinc finger protein ZFPM1; Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodim [...] |
| HPS1 protein network | https://string-db.org/network/9606.ENSP00000326649 | Hermansky-Pudlak syndrome 1 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting t [...] |
| FAM71F1 protein network | https://string-db.org/network/9606.ENSP00000326652 | Protein FAM71F1; Family with sequence similarity 71 member F1 |
| SLC47A2 protein network | https://string-db.org/network/9606.ENSP00000326671 | Multidrug and toxin extrusion protein 2; Solute transporter for tetraethylammonium (TEA), 1- methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide, metformin, creatinine, guanidine, p [...] |
| SLC25A42 protein network | https://string-db.org/network/9606.ENSP00000326693 | Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and [...] |
| CLGN protein network | https://string-db.org/network/9606.ENSP00000326699 | Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zo [...] |
| PLEKHO2 protein network | https://string-db.org/network/9606.ENSP00000326706 | Pleckstrin homology domain containing O2 |
| OVCH1 protein network | https://string-db.org/network/9606.ENSP00000326708 | Ovochymase-1; Ovochymase 1 |
| OR10A7 protein network | https://string-db.org/network/9606.ENSP00000326718 | Olfactory receptor 10A7; Odorant receptor; Olfactory receptors, family 10 |
| TNFRSF12A protein network | https://string-db.org/network/9606.ENSP00000326737 | Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. [...] |
| LRIG3 protein network | https://string-db.org/network/9606.ENSP00000326759 | Leucine-rich repeats and immunoglobulin-like domains protein 3; May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epitheliu [...] |
| MED25 protein network | https://string-db.org/network/9606.ENSP00000326767 | Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| CUL1 protein network | https://string-db.org/network/9606.ENSP00000326804 | Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle pr [...] |
| NCBP2 protein network | https://string-db.org/network/9606.ENSP00000326806 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRN [...] |
| YOD1 protein network | https://string-db.org/network/9606.ENSP00000326813 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. M [...] |
| LRRC57 protein network | https://string-db.org/network/9606.ENSP00000326817 | Leucine-rich repeat-containing protein 57; Leucine rich repeat containing 57 |
| C14orf28 protein network | https://string-db.org/network/9606.ENSP00000326846 | Uncharacterized protein C14orf28; Chromosome 14 open reading frame 28 |
| NT5DC1 protein network | https://string-db.org/network/9606.ENSP00000326858 | 5'-nucleotidase domain containing 1 |
| ORMDL1 protein network | https://string-db.org/network/9606.ENSP00000326869 | ORM1-like protein 1; Negative regulator of sphingolipid synthesis |
| C5orf22 protein network | https://string-db.org/network/9606.ENSP00000326879 | UPF0489 protein C5orf22; Chromosome 5 open reading frame 22; Belongs to the UPF0489 family |
| LIMS2 protein network | https://string-db.org/network/9606.ENSP00000326888 | LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface re [...] |
| SERTAD2 protein network | https://string-db.org/network/9606.ENSP00000326933 | SERTA domain-containing protein 2; Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivato [...] |
| FTSJ1 protein network | https://string-db.org/network/9606.ENSP00000326948 | Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs; Belongs to the c [...] |
| ZNF121 protein network | https://string-db.org/network/9606.ENSP00000326967 | Zinc finger protein 121; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IMP3 protein network | https://string-db.org/network/9606.ENSP00000326981 | U3 small nucleolar ribonucleoprotein protein IMP3; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processi [...] |
| CLIP4 protein network | https://string-db.org/network/9606.ENSP00000327009 | CAP-Gly domain containing linker protein family member 4 |
| RORC protein network | https://string-db.org/network/9606.ENSP00000327025 | Nuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequenc [...] |
| MAF protein network | https://string-db.org/network/9606.ENSP00000327048 | Transcription factor Maf; Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to cry [...] |
| LMNB2 protein network | https://string-db.org/network/9606.ENSP00000327054 | Lamin-B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope an [...] |
| MDH2 protein network | https://string-db.org/network/9606.ENSP00000327070 | Malate dehydrogenase, mitochondrial; Malate dehydrogenase 2 |
| PCM1 protein network | https://string-db.org/network/9606.ENSP00000327077 | Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Re [...] |
| DDHD1 protein network | https://string-db.org/network/9606.ENSP00000327104 | Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity; Belongs to the PA-P [...] |
| EHD3 protein network | https://string-db.org/network/9606.ENSP00000327116 | EH domain-containing protein 3; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding [...] |
| MIEF1 protein network | https://string-db.org/network/9606.ENSP00000327124 | Mitochondrial dynamics protein MID51; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related [...] |
| ZNF354B protein network | https://string-db.org/network/9606.ENSP00000327143 | Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FLNC protein network | https://string-db.org/network/9606.ENSP00000327145 | Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskel [...] |
| PRR7 protein network | https://string-db.org/network/9606.ENSP00000327168 | Proline-rich protein 7; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-media [...] |
| CIRH1A protein network | https://string-db.org/network/9606.ENSP00000327179 | U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at [...] |
| CCT6B protein network | https://string-db.org/network/9606.ENSP00000327191 | T-complex protein 1 subunit zeta-2; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity); [...] |
| SENP5 protein network | https://string-db.org/network/9606.ENSP00000327197 | Sentrin-specific protease 5; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targ [...] |
| ATP13A2 protein network | https://string-db.org/network/9606.ENSP00000327214 | Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintena [...] |
| TMCO5A protein network | https://string-db.org/network/9606.ENSP00000327234 | Transmembrane and coiled-coil domains 5A; Belongs to the TMCO5 family |
| VIPR1 protein network | https://string-db.org/network/9606.ENSP00000327246 | Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > [...] |
| NOS2 protein network | https://string-db.org/network/9606.ENSP00000327251 | Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal act [...] |
| PPM1A protein network | https://string-db.org/network/9606.ENSP00000327255 | Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear exp [...] |
| NDUFV2 protein network | https://string-db.org/network/9606.ENSP00000327268 | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minima [...] |
| ITGA11 protein network | https://string-db.org/network/9606.ENSP00000327290 | Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen |
| THNSL2 protein network | https://string-db.org/network/9606.ENSP00000327323 | Threonine synthase-like 2; Isoform 1: Acts as a catabolic phospho-lyase on both gamma- and beta-phosphorylated substrates. Degrades O-phospho- threonine (PThr) to alpha-ketobutyrate, ammonia and [...] |
| BGN protein network | https://string-db.org/network/9606.ENSP00000327336 | Biglycan; May be involved in collagen fiber assembly; Small leucine rich repeat proteoglycans |
| IGIP protein network | https://string-db.org/network/9606.ENSP00000327344 | IgA-inducing protein homolog; Enhances IgA secretion from B-cells stimulated via CD40 |
| COL10A1 protein network | https://string-db.org/network/9606.ENSP00000327368 | Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage; Collagens |
| GPR39 protein network | https://string-db.org/network/9606.ENSP00000327417 | G-protein coupled receptor 39; Zn(2+) acts as an agonist. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. It [...] |
| ZFP41 protein network | https://string-db.org/network/9606.ENSP00000327427 | ZFP41 zinc finger protein; A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis; Zinc fingers C2H2-type |
| HBG1 protein network | https://string-db.org/network/9606.ENSP00000327431 | Hemoglobin subunit gamma 1 |
| SETD3 protein network | https://string-db.org/network/9606.ENSP00000327436 | Histone-lysine N-methyltransferase setd3; Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3 (H3K4me and H3K36me). Acts as a transcriptional activator. Plays an importan [...] |
| BMP8A protein network | https://string-db.org/network/9606.ENSP00000327440 | Bone morphogenetic protein 8A; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...] |
| ACSM2B protein network | https://string-db.org/network/9606.ENSP00000327453 | Acyl-coenzyme A synthetase ACSM2B, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspo [...] |
| APOBEC3B protein network | https://string-db.org/network/9606.ENSP00000327459 | DNA dC->dU-editing enzyme APOBEC-3B; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| MYT1 protein network | https://string-db.org/network/9606.ENSP00000327465 | Myelin transcription factor 1; Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia [...] |
| SMDT1 protein network | https://string-db.org/network/9606.ENSP00000327467 | Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required t [...] |
| KLHDC8B protein network | https://string-db.org/network/9606.ENSP00000327468 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stabilit [...] |
| TSEN54 protein network | https://string-db.org/network/9606.ENSP00000327487 | tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. I [...] |
| C16orf54 protein network | https://string-db.org/network/9606.ENSP00000327506 | Transmembrane protein C16orf54; Chromosome 16 open reading frame 54 |
| STAC2 protein network | https://string-db.org/network/9606.ENSP00000327509 | SH3 and cysteine rich domain 2 |
| CSF1 protein network | https://string-db.org/network/9606.ENSP00000327513 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuc [...] |
| OR4F6 protein network | https://string-db.org/network/9606.ENSP00000327525 | Olfactory receptor 4F6; Odorant receptor; Olfactory receptors, family 4 |
| LYG2 protein network | https://string-db.org/network/9606.ENSP00000327533 | Lysozyme g-like protein 2; May act as a potent antibacterial protein that may play a role in the innate immunity; Belongs to the glycosyl hydrolase 23 family |
| ZNF534 protein network | https://string-db.org/network/9606.ENSP00000327538 | Zinc finger protein 534; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR51B2 protein network | https://string-db.org/network/9606.ENSP00000327540 | Olfactory receptor 51B2; Odorant receptor; Olfactory receptors, family 51 |
| NPTXR protein network | https://string-db.org/network/9606.ENSP00000327545 | Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of [...] |
| PAPL protein network | https://string-db.org/network/9606.ENSP00000327557 | Iron/zinc purple acid phosphatase-like protein ; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family |
| SLC22A10 protein network | https://string-db.org/network/9606.ENSP00000327569 | Solute carrier family 22 member 10 |
| OR1D2 protein network | https://string-db.org/network/9606.ENSP00000327585 | Olfactory receptor 1D2; Odorant receptor which may be involved in sperm chemotaxis. Bourgeonal is a strong chemoattractant for sperm in vitro and is shown to be a strong agonist for OR1D2 in vitr [...] |
| GLUD2 protein network | https://string-db.org/network/9606.ENSP00000327589 | Glutamate dehydrogenase 2, mitochondrial; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission; Belongs to the Glu/Leu/Phe/Val dehydrogenases family |
| CLEC4G protein network | https://string-db.org/network/9606.ENSP00000327599 | C-type lectin domain family 4 member G; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner, in vitro; C-type lectin domain containing |
| TRIM49 protein network | https://string-db.org/network/9606.ENSP00000327604 | Tripartite motif containing 49; Ring finger proteins |
| ADAMTSL5 protein network | https://string-db.org/network/9606.ENSP00000327608 | ADAMTS-like protein 5; May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM); ADAMTS like |
| KCNK12 protein network | https://string-db.org/network/9606.ENSP00000327611 | Potassium channel subfamily K member 12; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional [...] |
| VPS33B protein network | https://string-db.org/network/9606.ENSP00000327650 | Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysos [...] |
| LRRC14B protein network | https://string-db.org/network/9606.ENSP00000327675 | Leucine-rich repeat-containing protein 14B; Leucine rich repeat containing 14B; Belongs to the PRAME family. LRRC14 subfamily |
| AP2A2 protein network | https://string-db.org/network/9606.ENSP00000327694 | AP-2 complex subunit alpha-2; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathw [...] |
| WRB protein network | https://string-db.org/network/9606.ENSP00000327716 | Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane; Belongs to the WRB/GET1 family |
| TAS2R60 protein network | https://string-db.org/network/9606.ENSP00000327724 | Taste receptor type 2 member 60; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| C7orf61 protein network | https://string-db.org/network/9606.ENSP00000327732 | Uncharacterized protein C7orf61; Chromosome 7 open reading frame 61 |
| TRIML1 protein network | https://string-db.org/network/9606.ENSP00000327738 | Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development; Ring finger proteins |
| NKX2-5 protein network | https://string-db.org/network/9606.ENSP00000327758 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds [...] |
| NLRP10 protein network | https://string-db.org/network/9606.ENSP00000327763 | NACHT, LRR and PYD domains-containing protein 10; Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by F [...] |
| IZUMO1 protein network | https://string-db.org/network/9606.ENSP00000327786 | Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a [...] |
| DCAF4L1 protein network | https://string-db.org/network/9606.ENSP00000327796 | DDB1- and CUL4-associated factor 4-like protein 1; DDB1 and CUL4 associated factor 4 like 1; WD repeat domain containing |
| P4HB protein network | https://string-db.org/network/9606.ENSP00000327801 | Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves dis [...] |
| XPOT protein network | https://string-db.org/network/9606.ENSP00000327821 | Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear p [...] |
| IFNLR1 protein network | https://string-db.org/network/9606.ENSP00000327824 | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activ [...] |
| ATAT1 protein network | https://string-db.org/network/9606.ENSP00000327832 | Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynami [...] |
| SH2D7 protein network | https://string-db.org/network/9606.ENSP00000327846 | SH2 domain containing 7 |
| LPAR5 protein network | https://string-db.org/network/9606.ENSP00000327875 | Lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities |
| INTS5 protein network | https://string-db.org/network/9606.ENSP00000327889 | Integrator complex subunit 5; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| IL3RA protein network | https://string-db.org/network/9606.ENSP00000327890 | Interleukin-3 receptor subunit alpha; This is a receptor for interleukin-3; CD molecules |
| ACSM5 protein network | https://string-db.org/network/9606.ENSP00000327916 | Acyl-coenzyme A synthetase ACSM5, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspon [...] |
| SLC5A2 protein network | https://string-db.org/network/9606.ENSP00000327943 | Sodium/glucose cotransporter 2; Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1; Solute carriers |
| C19orf71 protein network | https://string-db.org/network/9606.ENSP00000327950 | Uncharacterized protein C19orf71; Chromosome 19 open reading frame 71 |
| TGIF1 protein network | https://string-db.org/network/9606.ENSP00000327959 | Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII- RXRE). Inhibits the 9-cis-retinoic acid-dependent RX [...] |
| SNAI3 protein network | https://string-db.org/network/9606.ENSP00000327968 | Zinc finger protein SNAI3; Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the [...] |
| DHRS7C protein network | https://string-db.org/network/9606.ENSP00000327975 | Dehydrogenase/reductase SDR family member 7C; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily |
| TRIM50 protein network | https://string-db.org/network/9606.ENSP00000327994 | E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase; Ring finger proteins |
| YAF2 protein network | https://string-db.org/network/9606.ENSP00000328004 | YY1 associated factor 2, isoform CRA_d; Zinc fingers RANBP2-type |
| TNFAIP8L3 protein network | https://string-db.org/network/9606.ENSP00000328016 | Tumor necrosis factor alpha-induced protein 8-like protein 3; Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- b [...] |
| KRBA2 protein network | https://string-db.org/network/9606.ENSP00000328017 | KRAB-A domain containing 2 |
| SRPR protein network | https://string-db.org/network/9606.ENSP00000328023 | Signal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targetin [...] |
| DGAT2L6 protein network | https://string-db.org/network/9606.ENSP00000328036 | Diacylglycerol O-acyltransferase 2-like protein 6; Probable acyltransferase uses fatty acyl-CoA as substrate (By similarity). Has no wax synthase activity to produce wax esters; Diacylglycerol O- [...] |
| CCDC144NL protein network | https://string-db.org/network/9606.ENSP00000328054 | Putative coiled-coil domain-containing protein 144 N-terminal-like; Coiled-coil domain containing 144 family, N-terminal like; Belongs to the CCDC144 family |
| RLIM protein network | https://string-db.org/network/9606.ENSP00000328059 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation [...] |
| C17orf74 protein network | https://string-db.org/network/9606.ENSP00000328061 | Uncharacterized protein SPEM2; Chromosome 17 open reading frame 74 |
| C6orf58 protein network | https://string-db.org/network/9606.ENSP00000328069 | Protein LEG1 homolog; May be involved in early liver development |
| GLTPD2 protein network | https://string-db.org/network/9606.ENSP00000328070 | Glycolipid transfer protein domain containing 2; Belongs to the GLTP family |
| WDR53 protein network | https://string-db.org/network/9606.ENSP00000328079 | WD repeat-containing protein 53; WD repeat domain containing; Belongs to the WD repeat WDR53 family |
| ARHGEF37 protein network | https://string-db.org/network/9606.ENSP00000328083 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF); Classical BAR domain containing |
| PAWR protein network | https://string-db.org/network/9606.ENSP00000328088 | PRKC apoptosis WT1 regulator protein; Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of [...] |
| OTOP3 protein network | https://string-db.org/network/9606.ENSP00000328090 | Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signal [...] |
| IL25 protein network | https://string-db.org/network/9606.ENSP00000328111 | Interleukin-25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses; Belongs to the IL-17 [...] |
| MCF2L2 protein network | https://string-db.org/network/9606.ENSP00000328118 | Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor; Belongs to the MCF2 family |
| IL20RB protein network | https://string-db.org/network/9606.ENSP00000328133 | Interleukin-20 receptor subunit beta; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24; Fibronectin type III domain containi [...] |
| OR7A17 protein network | https://string-db.org/network/9606.ENSP00000328144 | Olfactory receptor 7A17; Odorant receptor; Olfactory receptors, family 7 |
| SPATA8 protein network | https://string-db.org/network/9606.ENSP00000328149 | Spermatogenesis-associated protein 8; Spermatogenesis associated 8 |
| JAG2 protein network | https://string-db.org/network/9606.ENSP00000328169 | Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity) |
| PIF1 protein network | https://string-db.org/network/9606.ENSP00000328174 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) [...] |
| NOG protein network | https://string-db.org/network/9606.ENSP00000328181 | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formati [...] |
| CLN8 protein network | https://string-db.org/network/9606.ENSP00000328182 | Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death; TLC domain containing |
| FBXO21 protein network | https://string-db.org/network/9606.ENSP00000328187 | F-box only protein 21; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| TRAIP protein network | https://string-db.org/network/9606.ENSP00000328203 | E3 ubiquitin-protein ligase TRAIP; E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- a [...] |
| TNFRSF18 protein network | https://string-db.org/network/9606.ENSP00000328207 | Tumor necrosis factor receptor superfamily member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-c [...] |
| OR56A4 protein network | https://string-db.org/network/9606.ENSP00000328215 | Olfactory receptor 56A4; Odorant receptor; Olfactory receptors, family 56 |
| CDCA2 protein network | https://string-db.org/network/9606.ENSP00000328228 | Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts [...] |
| FFAR3 protein network | https://string-db.org/network/9606.ENSP00000328230 | Free fatty acid receptor 3; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulatio [...] |
| TCEB3C protein network | https://string-db.org/network/9606.ENSP00000328232 | Elongin-A3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit [...] |
| KNTC1 protein network | https://string-db.org/network/9606.ENSP00000328236 | Kinetochore-associated protein 1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-M [...] |
| ZNF71 protein network | https://string-db.org/network/9606.ENSP00000328245 | Endothelial zinc finger protein induced by tumor necrosis factor alpha; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MINA protein network | https://string-db.org/network/9606.ENSP00000328251 | Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 ( [...] |
| HMG20B protein network | https://string-db.org/network/9606.ENSP00000328269 | High mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promot [...] |
| KRTAP4-6 protein network | https://string-db.org/network/9606.ENSP00000328270 | Keratin-associated protein 4-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| B4GALNT4 protein network | https://string-db.org/network/9606.ENSP00000328277 | N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-lin [...] |
| RNF123 protein network | https://string-db.org/network/9606.ENSP00000328287 | E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B d [...] |
| FAM47B protein network | https://string-db.org/network/9606.ENSP00000328307 | Protein FAM47B; Family with sequence similarity 47 member B; Belongs to the FAM47 family |
| PTTG1IP protein network | https://string-db.org/network/9606.ENSP00000328325 | Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation |
| XKR4 protein network | https://string-db.org/network/9606.ENSP00000328326 | XK-related protein 4; XK related family |
| ASB7 protein network | https://string-db.org/network/9606.ENSP00000328327 | Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquiti [...] |
| CEND1 protein network | https://string-db.org/network/9606.ENSP00000328336 | Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation; Belongs to the CEND1 family |
| RNF135 protein network | https://string-db.org/network/9606.ENSP00000328340 | E3 ubiquitin-protein ligase RNF135; Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation [...] |
| FAM110C protein network | https://string-db.org/network/9606.ENSP00000328347 | Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway |
| KCTD11 protein network | https://string-db.org/network/9606.ENSP00000328352 | BTB/POZ domain-containing protein KCTD11; Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal g [...] |
| KRT79 protein network | https://string-db.org/network/9606.ENSP00000328358 | Keratin, type II cytoskeletal 79; Keratins, type II; Belongs to the intermediate filament family |
| DEFA3 protein network | https://string-db.org/network/9606.ENSP00000328359 | Neutrophil defensin 3; Defensin 2 and defensin 3 have antibiotic, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are t [...] |
| MAFA protein network | https://string-db.org/network/9606.ENSP00000328364 | Transcription factor MafA; Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 [...] |
| VMO1 protein network | https://string-db.org/network/9606.ENSP00000328397 | Vitelline membrane outer layer 1 homolog; Belongs to the VMO1 family |
| OR6C76 protein network | https://string-db.org/network/9606.ENSP00000328402 | Olfactory receptor 6C76; Odorant receptor; Olfactory receptors, family 6 |
| DGKA protein network | https://string-db.org/network/9606.ENSP00000328405 | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kin [...] |
| PDE6G protein network | https://string-db.org/network/9606.ENSP00000328412 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector mol [...] |
| REC114 protein network | https://string-db.org/network/9606.ENSP00000328423 | Meiotic recombination protein REC114; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC3 [...] |
| FAM208B protein network | https://string-db.org/network/9606.ENSP00000328426 | Protein FAM208B; Family with sequence similarity 208 member B; Belongs to the FAM208 family |
| KRTAP4-8 protein network | https://string-db.org/network/9606.ENSP00000328444 | Keratin-associated protein 4-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| S1PR5 protein network | https://string-db.org/network/9606.ENSP00000328472 | Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types o [...] |
| CNGA2 protein network | https://string-db.org/network/9606.ENSP00000328478 | Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to b [...] |
| HIST1H2AJ protein network | https://string-db.org/network/9606.ENSP00000328484 | Histone H2A type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| CCDC87 protein network | https://string-db.org/network/9606.ENSP00000328487 | Plays a role in spermatogenesis, where it is important for normal sperm head morphology. Also required for the acrosome reaction and thus normal male fertility |
| KCNA4 protein network | https://string-db.org/network/9606.ENSP00000328511 | Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective [...] |
| ZNF696 protein network | https://string-db.org/network/9606.ENSP00000328515 | Zinc finger protein 696; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DENND5A protein network | https://string-db.org/network/9606.ENSP00000328524 | DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound R [...] |
| DNMT3B protein network | https://string-db.org/network/9606.ENSP00000328547 | DNA (cytosine-5)-methyltransferase 3B; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coord [...] |
| RAB28 protein network | https://string-db.org/network/9606.ENSP00000328551 | Ras-related protein Rab-28; RAB28, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family |
| OR4D9 protein network | https://string-db.org/network/9606.ENSP00000328563 | Olfactory receptor 4D9; Odorant receptor; Olfactory receptors, family 4 |
| GLRX5 protein network | https://string-db.org/network/9606.ENSP00000328570 | Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Involved in protein lipoylation, acting in the pathway that provides an i [...] |
| SIX6 protein network | https://string-db.org/network/9606.ENSP00000328596 | Homeobox protein SIX6; May be involved in eye development; SINE class homeoboxes |
| HOXD1 protein network | https://string-db.org/network/9606.ENSP00000328598 | Homeobox protein Hox-D1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| NRROS protein network | https://string-db.org/network/9606.ENSP00000328625 | Negative regulator of reactive oxygen species; Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role du [...] |
| DSCR4 protein network | https://string-db.org/network/9606.ENSP00000328676 | Down syndrome critical region 4 |
| C2CD4C protein network | https://string-db.org/network/9606.ENSP00000328677 | C2 calcium-dependent domain-containing protein 4C; C2 calcium dependent domain containing 4C; Belongs to the C2CD4 family |
| MOB2 protein network | https://string-db.org/network/9606.ENSP00000328694 | MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L; Belongs to the MOB1/phocein family |
| C10orf107 protein network | https://string-db.org/network/9606.ENSP00000328698 | Ciliary-associated calcium-binding coiled-coil protein 1; Calcium-binding protein. May be involved in the control of sperm flagellar movement |
| RXFP3 protein network | https://string-db.org/network/9606.ENSP00000328708 | Relaxin-3 receptor 1; Receptor for RNL3/relaxin-3. Binding of the ligand inhibit cAMP accumulation; Relaxin family peptide receptors |
| FOXK1 protein network | https://string-db.org/network/9606.ENSP00000328720 | Forkhead box protein K1; Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene (By similarity). Important regulatory factor of the myogenic progenitor [...] |
| SEP15 protein network | https://string-db.org/network/9606.ENSP00000328729 | May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum . May re [...] |
| PRR23B protein network | https://string-db.org/network/9606.ENSP00000328768 | Proline-rich protein 23B; Proline rich 23B; Belongs to the PRR23 family |
| HEXIM1 protein network | https://string-db.org/network/9606.ENSP00000328773 | Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP com [...] |
| EFNA5 protein network | https://string-db.org/network/9606.ENSP00000328777 | Ephrin-A5; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...] |
| KCNH8 protein network | https://string-db.org/network/9606.ENSP00000328813 | Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties [...] |
| GPR132 protein network | https://string-db.org/network/9606.ENSP00000328818 | Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9- hydroxyoctadecadienoic acid (9-HODE). Activates a G [...] |
| TOP1MT protein network | https://string-db.org/network/9606.ENSP00000328835 | DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of t [...] |
| RBM10 protein network | https://string-db.org/network/9606.ENSP00000328848 | RNA-binding protein 10; May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for pol [...] |
| NOC4L protein network | https://string-db.org/network/9606.ENSP00000328854 | Nucleolar complex protein 4 homolog; Armadillo-like helical domain containing; Belongs to the CBF/MAK21 family |
| TRAK2 protein network | https://string-db.org/network/9606.ENSP00000328875 | Trafficking kinesin-binding protein 2; May regulate endosome-to-lysosome trafficking of membrane cargo, including EGFR |
| OR52E6 protein network | https://string-db.org/network/9606.ENSP00000328878 | Olfactory receptor 52E6; Odorant receptor; Olfactory receptors, family 52 |
| GTF2H2 protein network | https://string-db.org/network/9606.ENSP00000328901 | General transcription factor IIH subunit 2; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcrip [...] |
| KANK3 protein network | https://string-db.org/network/9606.ENSP00000328923 | KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing |
| HOXB4 protein network | https://string-db.org/network/9606.ENSP00000328928 | Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| OR2T11 protein network | https://string-db.org/network/9606.ENSP00000328934 | Olfactory receptor 2T11; Odorant receptor; Olfactory receptors, family 2 |
| AFMID protein network | https://string-db.org/network/9606.ENSP00000328938 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized [...] |
| SLX1B protein network | https://string-db.org/network/9606.ENSP00000328940 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombinati [...] |
| RPH3AL protein network | https://string-db.org/network/9606.ENSP00000328977 | Rab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epit [...] |
| CHST6 protein network | https://string-db.org/network/9606.ENSP00000328983 | Carbohydrate sulfotransferase 6; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...] |
| PAXBP1 protein network | https://string-db.org/network/9606.ENSP00000328992 | PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyl [...] |
| TRAK1 protein network | https://string-db.org/network/9606.ENSP00000328998 | Trafficking kinesin-binding protein 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors |
| HAX1 protein network | https://string-db.org/network/9606.ENSP00000329002 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. [...] |
| SLC25A18 protein network | https://string-db.org/network/9606.ENSP00000329033 | Mitochondrial glutamate carrier 2; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+); Solute carriers |
| FAM174B protein network | https://string-db.org/network/9606.ENSP00000329040 | Membrane protein FAM174B; Family with sequence similarity 174 member B |
| OR4C46 protein network | https://string-db.org/network/9606.ENSP00000329056 | Olfactory receptor 4C46; Odorant receptor; Olfactory receptors, family 4 |
| TPH2 protein network | https://string-db.org/network/9606.ENSP00000329093 | Tryptophan hydroxylase 2 |
| PHF6 protein network | https://string-db.org/network/9606.ENSP00000329097 | PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription; PHD finger proteins |
| LIN9 protein network | https://string-db.org/network/9606.ENSP00000329102 | Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expres [...] |
| AMER1 protein network | https://string-db.org/network/9606.ENSP00000329117 | APC membrane recruitment protein 1; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell [...] |
| PRKCH protein network | https://string-db.org/network/9606.ENSP00000329127 | Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in kera [...] |
| FAM132A protein network | https://string-db.org/network/9606.ENSP00000329137 | Adipolin; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo gl [...] |
| CREB3L2 protein network | https://string-db.org/network/9606.ENSP00000329140 | Cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted int [...] |
| OR6C70 protein network | https://string-db.org/network/9606.ENSP00000329153 | Olfactory receptor 6C70; Odorant receptor; Olfactory receptors, family 6 |
| CLRN1 protein network | https://string-db.org/network/9606.ENSP00000329158 | Clarin-1; May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina; Belongs to the cla [...] |
| KRT36 protein network | https://string-db.org/network/9606.ENSP00000329165 | Keratin, type I cuticular Ha6; Keratins, type I |
| POU3F2 protein network | https://string-db.org/network/9606.ENSP00000329170 | POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consist [...] |
| STAC3 protein network | https://string-db.org/network/9606.ENSP00000329200 | SH3 and cysteine-rich domain-containing protein 3; In skeletal muscles contraction, may play a role in neuromuscular synaptic transmission |
| OR2T10 protein network | https://string-db.org/network/9606.ENSP00000329210 | Olfactory receptor 2T10; Odorant receptor; Olfactory receptors, family 2 |
| SIVA1 protein network | https://string-db.org/network/9606.ENSP00000329213 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-media [...] |
| ST6GALNAC3 protein network | https://string-db.org/network/9606.ENSP00000329214 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-a [...] |
| FMNL1 protein network | https://string-db.org/network/9606.ENSP00000329219 | Formin-like protein 1; May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization [...] |
| KRT7 protein network | https://string-db.org/network/9606.ENSP00000329243 | Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA [...] |
| ZNF662 protein network | https://string-db.org/network/9606.ENSP00000329264 | Zinc finger protein 662; Zinc fingers C2H2-type |
| SNN protein network | https://string-db.org/network/9606.ENSP00000329287 | Stannin; Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation |
| GKN2 protein network | https://string-db.org/network/9606.ENSP00000329292 | Gastrokine-2; BRICHOS domain containing |
| NXPH3 protein network | https://string-db.org/network/9606.ENSP00000329295 | Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity); Belongs to the neurexophilin family |
| IGLL1 protein network | https://string-db.org/network/9606.ENSP00000329312 | Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development; C1-set domain containing |
| CECR6 protein network | https://string-db.org/network/9606.ENSP00000329318 | Transmembrane protein 121B; Cat eye syndrome chromosome region, candidate 6 |
| C17orf77 protein network | https://string-db.org/network/9606.ENSP00000329353 | Uncharacterized protein C17orf77; Chromosome 17 open reading frame 77 |
| SP1 protein network | https://string-db.org/network/9606.ENSP00000329357 | Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and reg [...] |
| CCDC137 protein network | https://string-db.org/network/9606.ENSP00000329360 | Coiled-coil domain containing 137 |
| SERPINA7 protein network | https://string-db.org/network/9606.ENSP00000329374 | Thyroxine-binding globulin; Major thyroid hormone transport protein in serum; Belongs to the serpin family |
| GP1BA protein network | https://string-db.org/network/9606.ENSP00000329380 | Platelet glycoprotein Ib alpha chain; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to [...] |
| PCP4 protein network | https://string-db.org/network/9606.ENSP00000329403 | Calmodulin regulator protein PCP4; Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may pla [...] |
| SOCS1 protein network | https://string-db.org/network/9606.ENSP00000329418 | Suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of [...] |
| COPB2 protein network | https://string-db.org/network/9606.ENSP00000329419 | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynth [...] |
| SLC25A21 protein network | https://string-db.org/network/9606.ENSP00000329452 | Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2- oxoglutarate, adipate, glutarate, and to a [...] |
| SIRT7 protein network | https://string-db.org/network/9606.ENSP00000329466 | NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetyla [...] |
| ENSG00000182974 protein network | https://string-db.org/network/9606.ENSP00000329467 | Uncharacterized protein; Odorant receptor; Olfactory receptors, family 4 |
| ADAP2 protein network | https://string-db.org/network/9606.ENSP00000329468 | Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inos [...] |
| KDELR1 protein network | https://string-db.org/network/9606.ENSP00000329471 | ER lumen protein-retaining receptor 1; Required for the retention of luminal endoplasmic reticulum resident proteins via vesicular recycling. This receptor recognizes the C-terminal K-D-E-L motif [...] |
| CD300C protein network | https://string-db.org/network/9606.ENSP00000329507 | CMRF35-like molecule 6; V-set domain containing; Belongs to the CD300 family |
| SPDYE4 protein network | https://string-db.org/network/9606.ENSP00000329522 | Speedy protein E4; speedy/RINGO cell cycle regulator family member E4; Belongs to the Speedy/Ringo family |
| TUSC5 protein network | https://string-db.org/network/9606.ENSP00000329548 | Tumor suppressor candidate 5; May be involved in fat metabolism; Belongs to the CD225/Dispanin family |
| TMEM89 protein network | https://string-db.org/network/9606.ENSP00000329557 | Transmembrane protein 89 |
| GRPEL2 protein network | https://string-db.org/network/9606.ENSP00000329558 | GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mit [...] |
| SPDYE3 protein network | https://string-db.org/network/9606.ENSP00000329565 | Speedy protein E3; speedy/RINGO cell cycle regulator family member E3 |
| ODF3L1 protein network | https://string-db.org/network/9606.ENSP00000329584 | Outer dense fiber of sperm tails 3 like 1; Belongs to the ODF3 family |
| YBEY protein network | https://string-db.org/network/9606.ENSP00000329614 | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation |
| ZNF804B protein network | https://string-db.org/network/9606.ENSP00000329638 | Zinc finger protein 804B |
| ACTL10 protein network | https://string-db.org/network/9606.ENSP00000329647 | Actin-like protein 10; Actin related proteins; Belongs to the actin family |
| WBSCR17 protein network | https://string-db.org/network/9606.ENSP00000329654 | Polypeptide N-acetylgalactosaminyltransferase 17; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or t [...] |
| H1FX protein network | https://string-db.org/network/9606.ENSP00000329662 | Histone H1x; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures |
| SHC4 protein network | https://string-db.org/network/9606.ENSP00000329668 | SHC-transforming protein 4; Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1; [...] |
| GALR2 protein network | https://string-db.org/network/9606.ENSP00000329684 | Galanin receptor type 2; Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1. The activity of this receptor is mediated by G proteins that activate the phospholipase C/pr [...] |
| OR10G7 protein network | https://string-db.org/network/9606.ENSP00000329689 | Olfactory receptor 10G7; Odorant receptor; Olfactory receptors, family 10 |
| PPAP2C protein network | https://string-db.org/network/9606.ENSP00000329697 | Phospholipid phosphatase 2; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphi [...] |
| DRG1 protein network | https://string-db.org/network/9606.ENSP00000329715 | Developmentally-regulated GTP-binding protein 1; Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest |
| FAM212A protein network | https://string-db.org/network/9606.ENSP00000329735 | PAK4-inhibitor INKA1; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity |
| CPNE8 protein network | https://string-db.org/network/9606.ENSP00000329748 | Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Copines |
| ATP6V0C protein network | https://string-db.org/network/9606.ENSP00000329757 | V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of [...] |
| ZNF85 protein network | https://string-db.org/network/9606.ENSP00000329793 | Zinc finger protein 85; May be a transcriptional repressor; Zinc fingers C2H2-type |
| TCEAL7 protein network | https://string-db.org/network/9606.ENSP00000329794 | Transcription elongation factor A protein-like 7; Plays a role in the negative regulation of NF-kappa-B signaling at the basal level by modulating transcriptional activity of NF-kappa-B on its ta [...] |
| TMEM105 protein network | https://string-db.org/network/9606.ENSP00000329795 | Transmembrane protein 105 |
| CADM1 protein network | https://string-db.org/network/9606.ENSP00000329797 | Cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent mann [...] |
| ZAR1 protein network | https://string-db.org/network/9606.ENSP00000329803 | Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition (By similarity); Zinc fingers 3CxxC-type |
| SPATA31A6 protein network | https://string-db.org/network/9606.ENSP00000329825 | Spermatogenesis-associated protein 31A6; May play a role in spermatogenesis |
| TRMT12 protein network | https://string-db.org/network/9606.ENSP00000329858 | tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guano [...] |
| CCDC172 protein network | https://string-db.org/network/9606.ENSP00000329860 | Coiled-coil domain containing 172 |
| PHACTR1 protein network | https://string-db.org/network/9606.ENSP00000329880 | Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell mo [...] |
| DEFA5 protein network | https://string-db.org/network/9606.ENSP00000329890 | Defensin-5; Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert a [...] |
| IQCF2 protein network | https://string-db.org/network/9606.ENSP00000329904 | IQ motif containing F2 |
| PSMG1 protein network | https://string-db.org/network/9606.ENSP00000329915 | Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 prot [...] |
| MEX3B protein network | https://string-db.org/network/9606.ENSP00000329918 | RNA-binding protein MEX3B; RNA-binding protein. May be involved in post- transcriptional regulatory mechanisms; Ring finger proteins |
| MCEMP1 protein network | https://string-db.org/network/9606.ENSP00000329920 | Mast cell expressed membrane protein 1 |
| CALHM1 protein network | https://string-db.org/network/9606.ENSP00000329926 | Calcium homeostasis modulator protein 1; Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II tas [...] |
| LGALS9C protein network | https://string-db.org/network/9606.ENSP00000329932 | Galectin-9C; Binds galactosides; Galectins |
| PHF12 protein network | https://string-db.org/network/9606.ENSP00000329933 | PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an assoc [...] |
| LRRC36 protein network | https://string-db.org/network/9606.ENSP00000329943 | Leucine-rich repeat-containing protein 36; Leucine rich repeat containing 36 |
| TBK1 protein network | https://string-db.org/network/9606.ENSP00000329967 | Serine/threonine-protein kinase TBK1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by v [...] |
| OR4F16 protein network | https://string-db.org/network/9606.ENSP00000329982 | Olfactory receptor, family 4, subfamily F, member 16; Odorant receptor; Olfactory receptors, family 4 |
| IFNL1 protein network | https://string-db.org/network/9606.ENSP00000329991 | Interferon lambda-1; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...] |
| FAM186A protein network | https://string-db.org/network/9606.ENSP00000329995 | Protein FAM186A; Family with sequence similarity 186 member A; Belongs to the FAM186 family |
| PIWIL3 protein network | https://string-db.org/network/9606.ENSP00000330031 | Piwi-like protein 3; May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRN [...] |
| UPP1 protein network | https://string-db.org/network/9606.ENSP00000330032 | Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized a [...] |
| OR4Q3 protein network | https://string-db.org/network/9606.ENSP00000330049 | Olfactory receptor 4Q3; Odorant receptor; Olfactory receptors, family 4 |
| MFSD6L protein network | https://string-db.org/network/9606.ENSP00000330051 | Major facilitator superfamily domain containing 6 like |
| NPW protein network | https://string-db.org/network/9606.ENSP00000330070 | Neuropeptide W; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hyp [...] |
| HIST1H1B protein network | https://string-db.org/network/9606.ENSP00000330074 | Histone H1.5; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...] |
| OGFOD3 protein network | https://string-db.org/network/9606.ENSP00000330075 | 2-oxoglutarate and iron dependent oxygenase domain containing 3; Belongs to the OGFOD3 family |
| FBXL6 protein network | https://string-db.org/network/9606.ENSP00000330098 | F-box/LRR-repeat protein 6; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| KRT76 protein network | https://string-db.org/network/9606.ENSP00000330101 | Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification; Keratins, type II |
| GRID1 protein network | https://string-db.org/network/9606.ENSP00000330148 | Glutamate receptor ionotropic, delta-1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu [...] |
| RSRC2 protein network | https://string-db.org/network/9606.ENSP00000330188 | Arginine and serine rich coiled-coil 2; Belongs to the RSRC2 family |
| SLC6A17 protein network | https://string-db.org/network/9606.ENSP00000330199 | Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of [...] |
| BTNL9 protein network | https://string-db.org/network/9606.ENSP00000330200 | Butyrophilin-like protein 9; V-set domain containing; Belongs to the immunoglobulin superfamily. BTN/MOG family |
| SOX1 protein network | https://string-db.org/network/9606.ENSP00000330218 | Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins an [...] |
| SPSB1 protein network | https://string-db.org/network/9606.ENSP00000330221 | SPRY domain-containing SOCS box protein 1; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the u [...] |
| CASP9 protein network | https://string-db.org/network/9606.ENSP00000330237 | Caspase-9; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates [...] |
| CCDC34 protein network | https://string-db.org/network/9606.ENSP00000330240 | Coiled-coil domain containing 34 |
| NT5DC4 protein network | https://string-db.org/network/9606.ENSP00000330247 | 5'-nucleotidase domain containing 4; Belongs to the 5'(3')-deoxyribonucleotidase family |
| TMPRSS9 protein network | https://string-db.org/network/9606.ENSP00000330264 | Transmembrane protease serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC [...] |
| C15orf32 protein network | https://string-db.org/network/9606.ENSP00000330267 | Uncharacterized protein C15orf32; Chromosome 15 open reading frame 32 |
| RESP18 protein network | https://string-db.org/network/9606.ENSP00000330269 | Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs; Belongs to the RESP18 family |
| PLEKHH1 protein network | https://string-db.org/network/9606.ENSP00000330278 | Pleckstrin homology, MyTH4 and FERM domain containing H1 |
| OR8B8 protein network | https://string-db.org/network/9606.ENSP00000330280 | Olfactory receptor 8B8; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 8 |
| NPBWR1 protein network | https://string-db.org/network/9606.ENSP00000330284 | Neuropeptides B/W receptor type 1; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food inta [...] |
| TRAPPC6B protein network | https://string-db.org/network/9606.ENSP00000330289 | Trafficking protein particle complex subunit 6B; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Trafficking protein particle complex |
| OR52L1 protein network | https://string-db.org/network/9606.ENSP00000330338 | Olfactory receptor 52L1; Odorant receptor; Olfactory receptors, family 52 |
| SOCS3 protein network | https://string-db.org/network/9606.ENSP00000330341 | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of [...] |
| C8orf33 protein network | https://string-db.org/network/9606.ENSP00000330361 | UPF0488 protein C8orf33; Chromosome 8 open reading frame 33; Belongs to the UPF0488 family |
| WDR5B protein network | https://string-db.org/network/9606.ENSP00000330381 | WD repeat-containing protein 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex; WD repeat domain containing |
| PDGFB protein network | https://string-db.org/network/9606.ENSP00000330382 | Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Poten [...] |
| OR6A2 protein network | https://string-db.org/network/9606.ENSP00000330384 | Olfactory receptor 6A2; Odorant receptor; Olfactory receptors, family 6 |
| PTRHD1 protein network | https://string-db.org/network/9606.ENSP00000330389 | peptidyl-tRNA hydrolase domain containing 1 |
| SPRR3 protein network | https://string-db.org/network/9606.ENSP00000330391 | Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Small proline rich proteins |
| LEPR protein network | https://string-db.org/network/9606.ENSP00000330393 | Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STA [...] |
| C1QTNF8 protein network | https://string-db.org/network/9606.ENSP00000330426 | Complement C1q tumor necrosis factor-related protein 8; C1q and TNF related 8 |
| FAM83F protein network | https://string-db.org/network/9606.ENSP00000330432 | Protein FAM83F; Family with sequence similarity 83 member F |
| TM2D3 protein network | https://string-db.org/network/9606.ENSP00000330433 | TM2 domain containing 3 |
| PLB1 protein network | https://string-db.org/network/9606.ENSP00000330442 | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Prefer [...] |
| DDX59 protein network | https://string-db.org/network/9606.ENSP00000330460 | Probable ATP-dependent RNA helicase DDX59; Zinc fingers HIT-type; Belongs to the DEAD box helicase family. DDX59 subfamily |
| TMPRSS11B protein network | https://string-db.org/network/9606.ENSP00000330475 | Transmembrane protease serine 11B; Serine protease |
| AMY1B protein network | https://string-db.org/network/9606.ENSP00000330484 | Belongs to the glycosyl hydrolase 13 family |
| ZDHHC23 protein network | https://string-db.org/network/9606.ENSP00000330485 | Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeti [...] |
| CXorf38 protein network | https://string-db.org/network/9606.ENSP00000330488 | Uncharacterized protein CXorf38; Chromosome X open reading frame 38 |
| DEXI protein network | https://string-db.org/network/9606.ENSP00000330509 | Dexamethasone-induced protein; Dexi homolog; Belongs to the DEXI family |
| CTHRC1 protein network | https://string-db.org/network/9606.ENSP00000330523 | Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition |
| MAPK8IP2 protein network | https://string-db.org/network/9606.ENSP00000330572 | C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK c [...] |
| MT1H protein network | https://string-db.org/network/9606.ENSP00000330587 | Metallothionein-1H; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| HHIPL1 protein network | https://string-db.org/network/9606.ENSP00000330601 | HHIP-like protein 1; Scavenger receptor cysteine rich domain containing |
| HS3ST4 protein network | https://string-db.org/network/9606.ENSP00000330606 | Heparan sulfate glucosamine 3-O-sulfotransferase 4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosami [...] |
| MRGPRG protein network | https://string-db.org/network/9606.ENSP00000330612 | Mas-related G-protein coupled receptor member G; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity); G protein-cou [...] |
| RTN4RL1 protein network | https://string-db.org/network/9606.ENSP00000330631 | Reticulon-4 receptor-like 1; Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Con [...] |
| CNTN2 protein network | https://string-db.org/network/9606.ENSP00000330633 | Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at t [...] |
| PAPPA protein network | https://string-db.org/network/9606.ENSP00000330658 | Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cle [...] |
| NDNL2 protein network | https://string-db.org/network/9606.ENSP00000330694 | Non-structural maintenance of chromosomes element 3 homolog; Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex [...] |
| P2RX7 protein network | https://string-db.org/network/9606.ENSP00000330696 | P2X purinoceptor 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecul [...] |
| KRTAP11-1 protein network | https://string-db.org/network/9606.ENSP00000330720 | Keratin-associated protein 11-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| COA5 protein network | https://string-db.org/network/9606.ENSP00000330730 | Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process |
| NDUFA12 protein network | https://string-db.org/network/9606.ENSP00000330737 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...] |
| KRTAP20-2 protein network | https://string-db.org/network/9606.ENSP00000330746 | Keratin-associated protein 20-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| BRWD1 protein network | https://string-db.org/network/9606.ENSP00000330753 | Bromodomain and WD repeat-containing protein 1; May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and [...] |
| NDUFB1 protein network | https://string-db.org/network/9606.ENSP00000330787 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved i [...] |
| OTOL1 protein network | https://string-db.org/network/9606.ENSP00000330808 | Otolin-1; C1q and TNF related ; Belongs to the OTOL1 family |
| ZNF775 protein network | https://string-db.org/network/9606.ENSP00000330838 | Zinc finger protein 775; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RGPD6 protein network | https://string-db.org/network/9606.ENSP00000330842 | RANBP2-like and GRIP domain-containing protein 5/6; Tetratricopeptide repeat domain containing |
| OPCML protein network | https://string-db.org/network/9606.ENSP00000330862 | Opioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family |
| FANCF protein network | https://string-db.org/network/9606.ENSP00000330875 | Fanconi anemia group F protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...] |
| KPNA7 protein network | https://string-db.org/network/9606.ENSP00000330878 | Importin subunit alpha-8; Functions in nuclear protein import; Belongs to the importin alpha family |
| POLR2J2 protein network | https://string-db.org/network/9606.ENSP00000330898 | DNA-directed RNA polymerase II subunit RPB11-b1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of R [...] |
| OR2T34 protein network | https://string-db.org/network/9606.ENSP00000330904 | Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2 |
| PGP protein network | https://string-db.org/network/9606.ENSP00000330918 | Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic inte [...] |
| TMED9 protein network | https://string-db.org/network/9606.ENSP00000330945 | Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport invo [...] |
| IL1R2 protein network | https://string-db.org/network/9606.ENSP00000330959 | Interleukin-1 receptor type 2; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL [...] |
| C10orf120 protein network | https://string-db.org/network/9606.ENSP00000331012 | Uncharacterized protein C10orf120; Chromosome 10 open reading frame 120 |
| RPS27L protein network | https://string-db.org/network/9606.ENSP00000331019 | Ribosomal protein S27 like; Belongs to the eukaryotic ribosomal protein eS27 family |
| OLIG2 protein network | https://string-db.org/network/9606.ENSP00000331040 | Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. C [...] |
| ENKUR protein network | https://string-db.org/network/9606.ENSP00000331044 | Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel; Cilia and flagella associated |
| VSTM4 protein network | https://string-db.org/network/9606.ENSP00000331062 | V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L-VGCC) currents in retinal photoreceptors; V-set domain containing |
| PPP1R27 protein network | https://string-db.org/network/9606.ENSP00000331065 | Protein phosphatase 1 regulatory subunit 27; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Ankyrin repeat domain containing |
| ODF4 protein network | https://string-db.org/network/9606.ENSP00000331086 | Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskel [...] |
| TSSC4 protein network | https://string-db.org/network/9606.ENSP00000331087 | Protein TSSC4; Tumor suppressing subtransferable candidate 4 |
| IP6K2 protein network | https://string-db.org/network/9606.ENSP00000331103 | Inositol hexakisphosphate kinase 2; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4; B [...] |
| PEX26 protein network | https://string-db.org/network/9606.ENSP00000331106 | Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required fo [...] |
| ZNRD1 protein network | https://string-db.org/network/9606.ENSP00000331111 | DNA-directed RNA polymerase I subunit RPA12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| BOLA2 protein network | https://string-db.org/network/9606.ENSP00000331127 | BolA-like protein 2; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothi [...] |
| MXI1 protein network | https://string-db.org/network/9606.ENSP00000331152 | Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus ant [...] |
| LMNTD2 protein network | https://string-db.org/network/9606.ENSP00000331167 | Lamin tail domain containing 2 |
| CD8B protein network | https://string-db.org/network/9606.ENSP00000331172 | T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and [...] |
| HGS protein network | https://string-db.org/network/9606.ENSP00000331201 | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA [...] |
| C11orf54 protein network | https://string-db.org/network/9606.ENSP00000331209 | Ester hydrolase C11orf54; Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate |
| BCAN protein network | https://string-db.org/network/9606.ENSP00000331210 | Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain [...] |
| RBM43 protein network | https://string-db.org/network/9606.ENSP00000331211 | RNA-binding protein 43; RNA binding motif containing |
| SMIM23 protein network | https://string-db.org/network/9606.ENSP00000331214 | Small integral membrane protein 23 |
| KREMEN1 protein network | https://string-db.org/network/9606.ENSP00000331242 | Kremen protein 1; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, [...] |
| POMK protein network | https://string-db.org/network/9606.ENSP00000331258 | Protein O-mannose kinase; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N- ac [...] |
| ANKRD45 protein network | https://string-db.org/network/9606.ENSP00000331268 | Ankyrin repeat domain-containing protein 45; Ankyrin repeat domain containing |
| TMEM173 protein network | https://string-db.org/network/9606.ENSP00000331288 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (I [...] |
| UBALD2 protein network | https://string-db.org/network/9606.ENSP00000331298 | UBA-like domain-containing protein 2; UBA like domain containing 2; Belongs to the UBALD family |
| TCEB3B protein network | https://string-db.org/network/9606.ENSP00000331302 | Elongin-A2; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit [...] |
| TOB2 protein network | https://string-db.org/network/9606.ENSP00000331305 | Protein Tob2; Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases; Belongs to the BTG family |
| MORF4L1 protein network | https://string-db.org/network/9606.ENSP00000331310 | Mortality factor 4-like protein 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucl [...] |
| GNB1L protein network | https://string-db.org/network/9606.ENSP00000331313 | G protein subunit beta 1 like; WD repeat domain containing |
| WT1 protein network | https://string-db.org/network/9606.ENSP00000331327 | Wilms tumor protein; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expre [...] |
| RAB11FIP1 protein network | https://string-db.org/network/9606.ENSP00000331342 | Rab11 family-interacting protein 1; A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in pha [...] |
| GAST protein network | https://string-db.org/network/9606.ENSP00000331358 | Gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increas [...] |
| BOLA3 protein network | https://string-db.org/network/9606.ENSP00000331369 | BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together w [...] |
| SERHL2 protein network | https://string-db.org/network/9606.ENSP00000331376 | Serine hydrolase-like protein 2; Probable serine hydrolase. May be related to cell muscle hypertrophy |
| KIAA0825 protein network | https://string-db.org/network/9606.ENSP00000331385 | Uncharacterized protein KIAA0825; Armadillo-like helical domain containing |
| FAM43B protein network | https://string-db.org/network/9606.ENSP00000331397 | Protein FAM43B; Family with sequence similarity 43 member B; Belongs to the FAM43 family |
| FBLN7 protein network | https://string-db.org/network/9606.ENSP00000331411 | Fibulin-7; An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as i [...] |
| MBD3L5 protein network | https://string-db.org/network/9606.ENSP00000331435 | methyl-CpG binding domain protein 3 like 5 |
| ZNF704 protein network | https://string-db.org/network/9606.ENSP00000331462 | Transcription factor which binds to RE2 sequence elements in the MYOD1 enhancer |
| ZNF84 protein network | https://string-db.org/network/9606.ENSP00000331465 | Zinc finger protein 84; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TMEM95 protein network | https://string-db.org/network/9606.ENSP00000331466 | Transmembrane protein 95 |
| DBX2 protein network | https://string-db.org/network/9606.ENSP00000331470 | Homeobox protein DBX2; NKL subclass homeoboxes and pseudogenes |
| SYNDIG1L protein network | https://string-db.org/network/9606.ENSP00000331474 | Synapse differentiation-inducing gene protein 1-like; Interferon induced transmembrane protein domain containing |
| CYB5D1 protein network | https://string-db.org/network/9606.ENSP00000331479 | Cytochrome b5 domain containing 1 |
| NPLOC4 protein network | https://string-db.org/network/9606.ENSP00000331487 | Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER [...] |
| TEX19 protein network | https://string-db.org/network/9606.ENSP00000331500 | Testis-expressed protein 19; Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates w [...] |
| FES protein network | https://string-db.org/network/9606.ENSP00000331504 | Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell at [...] |
| SPATA32 protein network | https://string-db.org/network/9606.ENSP00000331532 | Spermatogenesis-associated protein 32; Spermatogenesis associated 32 |
| FBLN1 protein network | https://string-db.org/network/9606.ENSP00000331544 | Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important fo [...] |
| OR1G1 protein network | https://string-db.org/network/9606.ENSP00000331545 | Olfactory receptor 1G1; Odorant receptor; Olfactory receptors, family 1 |
| CYLC1 protein network | https://string-db.org/network/9606.ENSP00000331556 | Cylicin-1; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation |
| OR56A3 protein network | https://string-db.org/network/9606.ENSP00000331572 | Olfactory receptor 56A3; Odorant receptor; Olfactory receptors, family 56 |
| ZNF397 protein network | https://string-db.org/network/9606.ENSP00000331577 | Zinc finger protein 397; Isoform 3 acts as a DNA-dependent transcriptional repressor; SCAN domain containing |
| C11orf87 protein network | https://string-db.org/network/9606.ENSP00000331581 | Uncharacterized protein C11orf87; Chromosome 11 open reading frame 87 |
| GPR173 protein network | https://string-db.org/network/9606.ENSP00000331600 | Probable G-protein coupled receptor 173; Orphan receptor; G protein-coupled receptors, Class A orphans |
| IRX3 protein network | https://string-db.org/network/9606.ENSP00000331608 | Iroquois-class homeodomain protein IRX-3; Transcription factor. Involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to th [...] |
| IKZF1 protein network | https://string-db.org/network/9606.ENSP00000331614 | DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Plays a role in the development of lymphocytes, B- and T-cells. Binds and act [...] |
| ZKSCAN2 protein network | https://string-db.org/network/9606.ENSP00000331626 | Zinc finger protein with KRAB and SCAN domains 2; May be involved in transcriptional regulation; Myb/SANT domain containing |
| CAPN12 protein network | https://string-db.org/network/9606.ENSP00000331636 | Calpain-12; Calcium-regulated non-lysosomal thiol-protease; Calpains |
| TMEM186 protein network | https://string-db.org/network/9606.ENSP00000331640 | Transmembrane protein 186 |
| PGBD2 protein network | https://string-db.org/network/9606.ENSP00000331643 | piggyBac transposable element derived 2; DNA transposon derived genes |
| ARMCX2 protein network | https://string-db.org/network/9606.ENSP00000331662 | Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing |
| PKP3 protein network | https://string-db.org/network/9606.ENSP00000331678 | Plakophilin-3; May play a role in junctional plaques; Armadillo repeat containing |
| DGCR6 protein network | https://string-db.org/network/9606.ENSP00000331681 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family |
| KLHL22 protein network | https://string-db.org/network/9606.ENSP00000331682 | Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) [...] |
| C12orf60 protein network | https://string-db.org/network/9606.ENSP00000331691 | Uncharacterized protein C12orf60; Chromosome 12 open reading frame 60 |
| KCNJ15 protein network | https://string-db.org/network/9606.ENSP00000331698 | ATP-sensitive inward rectifier potassium channel 15; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Th [...] |
| XKR3 protein network | https://string-db.org/network/9606.ENSP00000331704 | XK-related protein 3; XK related family; Belongs to the XK family |
| C16orf72 protein network | https://string-db.org/network/9606.ENSP00000331720 | UPF0472 protein C16orf72; Chromosome 16 open reading frame 72 |
| KCNH7 protein network | https://string-db.org/network/9606.ENSP00000331727 | Potassium voltage-gated channel subfamily H member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly; Belongs to [...] |
| RIPPLY3 protein network | https://string-db.org/network/9606.ENSP00000331734 | Protein ripply3; Acts as a transcriptional corepressor. Negative regulator of the transcriptional activity of TBX1. Plays a role in the development of the pharyngeal apparatus and derivatives (By [...] |
| SELE protein network | https://string-db.org/network/9606.ENSP00000331736 | E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May h [...] |
| HOXB2 protein network | https://string-db.org/network/9606.ENSP00000331741 | Homeobox protein Hox-B2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| GDF3 protein network | https://string-db.org/network/9606.ENSP00000331745 | Growth/differentiation factor 3; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and me [...] |
| CALCA protein network | https://string-db.org/network/9606.ENSP00000331746 | Calcitonin; Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones; Endogenous ligands |
| RAB12 protein network | https://string-db.org/network/9606.ENSP00000331748 | Ras-related protein Rab-12; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| OR2T29 protein network | https://string-db.org/network/9606.ENSP00000331774 | Olfactory receptor 2T29; Odorant receptor; Olfactory receptors, family 2 |
| OR10J3 protein network | https://string-db.org/network/9606.ENSP00000331789 | Olfactory receptor 10J3; Odorant receptor; Olfactory receptors, family 10 |
| TBX1 protein network | https://string-db.org/network/9606.ENSP00000331791 | T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity); T-boxe [...] |
| OR5P2 protein network | https://string-db.org/network/9606.ENSP00000331823 | Olfactory receptor 5P2; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 5 |
| GAS6 protein network | https://string-db.org/network/9606.ENSP00000331831 | Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6 [...] |
| NPIPA1 protein network | https://string-db.org/network/9606.ENSP00000331843 | Nuclear pore complex interacting protein family member A1 |
| PRR14L protein network | https://string-db.org/network/9606.ENSP00000331845 | Protein PRR14L; Proline rich 14 like |
| MRPL54 protein network | https://string-db.org/network/9606.ENSP00000331849 | Mitochondrial ribosomal protein L54 |
| NLRP9 protein network | https://string-db.org/network/9606.ENSP00000331857 | NACHT, LRR and PYD domains-containing protein 9; As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including r [...] |
| TAS1R1 protein network | https://string-db.org/network/9606.ENSP00000331867 | Taste receptor type 1 member 1; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species ca [...] |
| PRMT3 protein network | https://string-db.org/network/9606.ENSP00000331879 | Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins; Protein arginine methyltransferases |
| IDH2 protein network | https://string-db.org/network/9606.ENSP00000331897 | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belong [...] |
| EEF1G protein network | https://string-db.org/network/9606.ENSP00000331901 | Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components |
| COL4A5 protein network | https://string-db.org/network/9606.ENSP00000331902 | Collagen alpha-5(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| DHX34 protein network | https://string-db.org/network/9606.ENSP00000331907 | Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; DEAH-box helicases |
| FAM101B protein network | https://string-db.org/network/9606.ENSP00000331915 | Refilin-B; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elem [...] |
| ZNF789 protein network | https://string-db.org/network/9606.ENSP00000331927 | Zinc finger protein 789; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| WSCD2 protein network | https://string-db.org/network/9606.ENSP00000331933 | WSC domain containing 2; Belongs to the WSCD family |
| AEN protein network | https://string-db.org/network/9606.ENSP00000331944 | Apoptosis-enhancing nuclease; Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double- [...] |
| TLCD2 protein network | https://string-db.org/network/9606.ENSP00000331965 | Regulates the composition and fluidity of the plasma membrane . Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) [...] |
| LRRC16A protein network | https://string-db.org/network/9606.ENSP00000331983 | F-actin-uncapping protein LRRC16A; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin [...] |
| ZGPAT protein network | https://string-db.org/network/9606.ENSP00000332013 | Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting t [...] |
| PROSER1 protein network | https://string-db.org/network/9606.ENSP00000332034 | Proline and serine rich 1 |
| CD86 protein network | https://string-db.org/network/9606.ENSP00000332049 | T-lymphocyte activation antigen CD86; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a cr [...] |
| SNX20 protein network | https://string-db.org/network/9606.ENSP00000332062 | Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalizati [...] |
| OR5P3 protein network | https://string-db.org/network/9606.ENSP00000332068 | Olfactory receptor 5P3; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 5 |
| NAA38 protein network | https://string-db.org/network/9606.ENSP00000332103 | N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; LSm p [...] |
| OR4N5 protein network | https://string-db.org/network/9606.ENSP00000332110 | Olfactory receptor 4N5; Odorant receptor; Olfactory receptors, family 4 |
| EFCAB13 protein network | https://string-db.org/network/9606.ENSP00000332111 | EF-hand calcium-binding domain-containing protein 13; EF-hand calcium binding domain 13 |
| PDE4B protein network | https://string-db.org/network/9606.ENSP00000332116 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central ner [...] |
| EPHB3 protein network | https://string-db.org/network/9606.ENSP00000332118 | Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| PRAMEF1 protein network | https://string-db.org/network/9606.ENSP00000332134 | PRAME family member 1; Belongs to the PRAME family |
| CFD protein network | https://string-db.org/network/9606.ENSP00000332139 | Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its funct [...] |
| DZIP1L protein network | https://string-db.org/network/9606.ENSP00000332148 | Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane; Belongs to [...] |
| DSE protein network | https://string-db.org/network/9606.ENSP00000332151 | Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues |
| C1orf64 protein network | https://string-db.org/network/9606.ENSP00000332162 | Steroid receptor-associated and regulated protein; May regulate the transcriptional function of androgen and estrogen receptors |
| SPRR4 protein network | https://string-db.org/network/9606.ENSP00000332163 | Small proline-rich protein 4; Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification; Belongs to the cornifin (SPRR) family |
| SLIT3 protein network | https://string-db.org/network/9606.ENSP00000332164 | Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors |
| OR2V2 protein network | https://string-db.org/network/9606.ENSP00000332185 | Olfactory receptor 2V2; Odorant receptor; Olfactory receptors, family 2 |
| HIST2H2AC protein network | https://string-db.org/network/9606.ENSP00000332194 | Histone H2A type 2-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| NOP10 protein network | https://string-db.org/network/9606.ENSP00000332198 | H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes p [...] |
| RFX6 protein network | https://string-db.org/network/9606.ENSP00000332208 | DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 isl [...] |
| PSG3 protein network | https://string-db.org/network/9606.ENSP00000332215 | Pregnancy specific beta-1-glycoprotein 3; Belongs to the immunoglobulin superfamily. CEA family |
| PMCH protein network | https://string-db.org/network/9606.ENSP00000332225 | Pro-MCH; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arou [...] |
| ATP6V0A2 protein network | https://string-db.org/network/9606.ENSP00000332247 | V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi func [...] |
| ALDH1A3 protein network | https://string-db.org/network/9606.ENSP00000332256 | Aldehyde dehydrogenase family 1 member A3; NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitr [...] |
| PTP4A3 protein network | https://string-db.org/network/9606.ENSP00000332274 | Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive act [...] |
| SYNGR1 protein network | https://string-db.org/network/9606.ENSP00000332287 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesic [...] |
| TRIM61 protein network | https://string-db.org/network/9606.ENSP00000332288 | Putative tripartite motif-containing protein 61; Tripartite motif containing 61; Ring finger proteins |
| ASCL2 protein network | https://string-db.org/network/9606.ENSP00000332293 | Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system; Basic helix-loop-helix protein [...] |
| RARB protein network | https://string-db.org/network/9606.ENSP00000332296 | Retinoic acid receptor beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic a [...] |
| ZNF703 protein network | https://string-db.org/network/9606.ENSP00000332325 | Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates ce [...] |
| DDX28 protein network | https://string-db.org/network/9606.ENSP00000332340 | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this [...] |
| PTCH1 protein network | https://string-db.org/network/9606.ENSP00000332353 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's p [...] |
| ALAS2 protein network | https://string-db.org/network/9606.ENSP00000332369 | 5-aminolevulinate synthase, erythroid-specific, mitochondrial; 5'-aminolevulinate synthase 2 |
| COL7A1 protein network | https://string-db.org/network/9606.ENSP00000332371 | Collagen alpha-1(VII) chain; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence [...] |
| TMIGD1 protein network | https://string-db.org/network/9606.ENSP00000332404 | Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative [...] |
| SDR42E1 protein network | https://string-db.org/network/9606.ENSP00000332407 | Short chain dehydrogenase/reductase family 42E, member 1 |
| BEST3 protein network | https://string-db.org/network/9606.ENSP00000332413 | Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family |
| ZSCAN22 protein network | https://string-db.org/network/9606.ENSP00000332433 | Zinc finger and SCAN domain-containing protein 22; May be involved in transcriptional regulation; SCAN domain containing |
| CSTF2T protein network | https://string-db.org/network/9606.ENSP00000332444 | Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similari [...] |
| ADAT3 protein network | https://string-db.org/network/9606.ENSP00000332448 | Probable inactive tRNA-specific adenosine deaminase-like protein 3; Adenosine deaminase, tRNA specific 3; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily |
| CRIP1 protein network | https://string-db.org/network/9606.ENSP00000332449 | Cysteine-rich protein 1; Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein; LIM domain containing |
| RIPK4 protein network | https://string-db.org/network/9606.ENSP00000332454 | Receptor-interacting serine/threonine-protein kinase 4; Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation; Belong [...] |
| OR51J1 protein network | https://string-db.org/network/9606.ENSP00000332473 | Olfactory receptor 51J1; Odorant receptor; Olfactory receptors, family 51 |
| SPPL2C protein network | https://string-db.org/network/9606.ENSP00000332488 | Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane |
| OR4N4 protein network | https://string-db.org/network/9606.ENSP00000332500 | Olfactory receptor 4N4; Odorant receptor; Olfactory receptors, family 4 |
| CCR10 protein network | https://string-db.org/network/9606.ENSP00000332504 | C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B [...] |
| OLFML1 protein network | https://string-db.org/network/9606.ENSP00000332511 | Olfactomedin-like protein 1; Olfactomedin like 1 |
| SH3BGR protein network | https://string-db.org/network/9606.ENSP00000332513 | SH3 domain-binding glutamic acid-rich protein; SH3 domain binding glutamate rich protein; Belongs to the SH3BGR family |
| OTOP2 protein network | https://string-db.org/network/9606.ENSP00000332528 | Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signal [...] |
| RNLS protein network | https://string-db.org/network/9606.ENSP00000332530 | Renalase; Catalyzes the oxidation of the less abundant 1,2- dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta- NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates i [...] |
| SULT4A1 protein network | https://string-db.org/network/9606.ENSP00000332565 | Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxin [...] |
| OSBP2 protein network | https://string-db.org/network/9606.ENSP00000332576 | Oxysterol-binding protein 2; Binds 7-ketocholesterol; Oxysterol binding proteins |
| NPY2R protein network | https://string-db.org/network/9606.ENSP00000332591 | Neuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-3 [...] |
| SPAG16 protein network | https://string-db.org/network/9606.ENSP00000332592 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate [...] |
| ZNF92 protein network | https://string-db.org/network/9606.ENSP00000332595 | Zinc finger protein 92; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CTAG1B protein network | https://string-db.org/network/9606.ENSP00000332602 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family |
| EIF3C protein network | https://string-db.org/network/9606.ENSP00000332604 | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| OAF protein network | https://string-db.org/network/9606.ENSP00000332613 | Out at first homolog; Belongs to the OAF family |
| NDN protein network | https://string-db.org/network/9606.ENSP00000332643 | Necdin; Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- p [...] |
| MFSD10 protein network | https://string-db.org/network/9606.ENSP00000332646 | Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as a [...] |
| ENPP7 protein network | https://string-db.org/network/9606.ENSP00000332656 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7; Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to ha [...] |
| CCR4 protein network | https://string-db.org/network/9606.ENSP00000332659 | C-C chemokine receptor type 4; High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which [...] |
| FAM65C protein network | https://string-db.org/network/9606.ENSP00000332663 | Family with sequence similarity 65, member C |
| LRRC8B protein network | https://string-db.org/network/9606.ENSP00000332674 | Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...] |
| CYP2A13 protein network | https://string-db.org/network/9606.ENSP00000332679 | Cytochrome P450 2A13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphen [...] |
| LRP2BP protein network | https://string-db.org/network/9606.ENSP00000332681 | LRP2-binding protein; May act as an adapter that regulates LRP2 function |
| KRTAP6-1 protein network | https://string-db.org/network/9606.ENSP00000332690 | Keratin-associated protein 6-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| PURA protein network | https://string-db.org/network/9606.ENSP00000332706 | Transcriptional activator protein Pur-alpha; This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. [...] |
| COLEC10 protein network | https://string-db.org/network/9606.ENSP00000332723 | Collectin-10; Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of ce [...] |
| UNC5A protein network | https://string-db.org/network/9606.ENSP00000332737 | Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neu [...] |
| ALX4 protein network | https://string-db.org/network/9606.ENSP00000332744 | Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development; Belongs t [...] |
| ZKSCAN8 protein network | https://string-db.org/network/9606.ENSP00000332750 | Zinc finger protein with KRAB and SCAN domains 8; May be involved in transcriptional regulation; SCAN domain containing |
| ATP11C protein network | https://string-db.org/network/9606.ENSP00000332756 | Phospholipid-transporting ATPase IG; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| FUT10 protein network | https://string-db.org/network/9606.ENSP00000332757 | Alpha-(1,3)-fucosyltransferase 10; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family |
| NPB protein network | https://string-db.org/network/9606.ENSP00000332766 | Neuropeptide B; May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway; Endogenous ligands |
| CLCNKA protein network | https://string-db.org/network/9606.ENSP00000332771 | Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transdu [...] |
| YIPF7 protein network | https://string-db.org/network/9606.ENSP00000332772 | Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family |
| IGDCC3 protein network | https://string-db.org/network/9606.ENSP00000332773 | Immunoglobulin superfamily DCC subclass member 3; Fibronectin type III domain containing |
| ANO9 protein network | https://string-db.org/network/9606.ENSP00000332788 | Anoctamin-9; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated [...] |
| HIST2H2AB protein network | https://string-db.org/network/9606.ENSP00000332790 | Histone H2A type 2-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| KLHL15 protein network | https://string-db.org/network/9606.ENSP00000332791 | Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PP [...] |
| KRTAP8-1 protein network | https://string-db.org/network/9606.ENSP00000332805 | Keratin-associated protein 8-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| EMILIN3 protein network | https://string-db.org/network/9606.ENSP00000332806 | EMILIN-3; Elastin microfibril interfacer 3; EMI domain containing |
| C2orf71 protein network | https://string-db.org/network/9606.ENSP00000332809 | Uncharacterized protein C2orf71; May play an important role in the development of normal vision |
| PTGDR2 protein network | https://string-db.org/network/9606.ENSP00000332812 | Prostaglandin D2 receptor 2; Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mo [...] |
| ZNF530 protein network | https://string-db.org/network/9606.ENSP00000332861 | Zinc finger protein 530; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| C2orf70 protein network | https://string-db.org/network/9606.ENSP00000332875 | UPF0573 protein C2orf70; Chromosome 2 open reading frame 70; Belongs to the UPF0573 family |
| FLRT2 protein network | https://string-db.org/network/9606.ENSP00000332879 | Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also [...] |
| FREM3 protein network | https://string-db.org/network/9606.ENSP00000332886 | FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion |
| UQCR10 protein network | https://string-db.org/network/9606.ENSP00000332887 | Cytochrome b-c1 complex subunit 9; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory cha [...] |
| GPR97 protein network | https://string-db.org/network/9606.ENSP00000332900 | Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development (By sim [...] |
| PARPBP protein network | https://string-db.org/network/9606.ENSP00000332915 | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologou [...] |
| FOLR4 protein network | https://string-db.org/network/9606.ENSP00000332963 | Sperm-egg fusion protein Juno; Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO [...] |
| SMAD3 protein network | https://string-db.org/network/9606.ENSP00000332973 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth fac [...] |
| BACE2 protein network | https://string-db.org/network/9606.ENSP00000332979 | Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release [...] |
| WBP2NL protein network | https://string-db.org/network/9606.ENSP00000332983 | Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization; GRAM domain containi [...] |
| PRSS55 protein network | https://string-db.org/network/9606.ENSP00000333003 | Serine protease 55; Probable serine protease |
| SS18L1 protein network | https://string-db.org/network/9606.ENSP00000333012 | Calcium-responsive transactivator; Transcriptional activator which is required for calcium- dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to [...] |
| TTC32 protein network | https://string-db.org/network/9606.ENSP00000333018 | Tetratricopeptide repeat domain containing |
| ADSSL1 protein network | https://string-db.org/network/9606.ENSP00000333019 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes [...] |
| PHF7 protein network | https://string-db.org/network/9606.ENSP00000333024 | PHD finger protein 7; May play a role in spermatogenesis; PHD finger proteins |
| ACTRT3 protein network | https://string-db.org/network/9606.ENSP00000333037 | Actin related protein T3 |
| C14orf180 protein network | https://string-db.org/network/9606.ENSP00000333041 | Nutritionally-regulated adipose and cardiac enriched protein homolog; Chromosome 14 open reading frame 180 |
| FIGLA protein network | https://string-db.org/network/9606.ENSP00000333097 | Factor in the germline alpha; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-spec [...] |
| PLA2G6 protein network | https://string-db.org/network/9606.ENSP00000333142 | 85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopres [...] |
| GH2 protein network | https://string-db.org/network/9606.ENSP00000333157 | Growth hormone 1 isoform 5; Growth hormone family; Endogenous ligands |
| MARCH11 protein network | https://string-db.org/network/9606.ENSP00000333181 | E3 ubiquitin-protein ligase MARCH11; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form [...] |
| MBD3L3 protein network | https://string-db.org/network/9606.ENSP00000333183 | methyl-CpG binding domain protein 3 like 3 |
| OR4F15 protein network | https://string-db.org/network/9606.ENSP00000333184 | Olfactory receptor 4F15; Odorant receptor; Olfactory receptors, family 4 |
| FOXL2 protein network | https://string-db.org/network/9606.ENSP00000333188 | Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Pr [...] |
| OR51M1 protein network | https://string-db.org/network/9606.ENSP00000333196 | Olfactory receptor 51M1; Odorant receptor; Olfactory receptors, family 51 |
| SERPINA5 protein network | https://string-db.org/network/9606.ENSP00000333203 | Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation [...] |
| CYP2U1 protein network | https://string-db.org/network/9606.ENSP00000333212 | Cytochrome P450 2U1; Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in [...] |
| ZNF470 protein network | https://string-db.org/network/9606.ENSP00000333223 | Zinc finger protein 470; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| DEFB108B protein network | https://string-db.org/network/9606.ENSP00000333234 | Beta-defensin 108B; Has antibacterial activity; Defensins, beta |
| VMA21 protein network | https://string-db.org/network/9606.ENSP00000333255 | Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum |
| INPP5J protein network | https://string-db.org/network/9606.ENSP00000333262 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bi [...] |
| UBA7 protein network | https://string-db.org/network/9606.ENSP00000333266 | Ubiquitin-like modifier-activating enzyme 7; Activates ubiquitin by first adenylating with ATP its C- terminal glycine residue and thereafter linking this residue to the side chain of a cysteine [...] |
| NR2C1 protein network | https://string-db.org/network/9606.ENSP00000333275 | Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor [...] |
| HIST2H3D protein network | https://string-db.org/network/9606.ENSP00000333277 | Histone cluster 2 H3 family member d; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| C17orf70 protein network | https://string-db.org/network/9606.ENSP00000333283 | Fanconi anemia core complex-associated protein 100; Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core com [...] |
| SPNS2 protein network | https://string-db.org/network/9606.ENSP00000333292 | Protein spinster homolog 2; Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles [...] |
| LAMP1 protein network | https://string-db.org/network/9606.ENSP00000333298 | Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; CD molecules |
| HSD17B13 protein network | https://string-db.org/network/9606.ENSP00000333300 | 17-beta-hydroxysteroid dehydrogenase 13; Short chain dehydrogenase/reductase superfamily |
| SULT1C3 protein network | https://string-db.org/network/9606.ENSP00000333310 | Sulfotransferase 1C3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor and has low sulphotransferase activity towards various substrates with alcohol groups [...] |
| TUBA8 protein network | https://string-db.org/network/9606.ENSP00000333326 | Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...] |
| USP17L2 protein network | https://string-db.org/network/9606.ENSP00000333329 | Ubiquitin carboxyl-terminal hydrolase 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation b [...] |
| JRKL protein network | https://string-db.org/network/9606.ENSP00000333350 | Jerky protein homolog-like; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family |
| RNASE10 protein network | https://string-db.org/network/9606.ENSP00000333358 | Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pe [...] |
| DNAH8 protein network | https://string-db.org/network/9606.ENSP00000333363 | Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| CCDC60 protein network | https://string-db.org/network/9606.ENSP00000333374 | Coiled-coil domain containing 60 |
| USP45 protein network | https://string-db.org/network/9606.ENSP00000333376 | May be involved in the maintenance of photoreceptor function. |
| ARSI protein network | https://string-db.org/network/9606.ENSP00000333395 | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is [...] |
| MRPL40 protein network | https://string-db.org/network/9606.ENSP00000333401 | Mitochondrial ribosomal protein L40; Belongs to the mitochondrion-specific ribosomal protein mL40 family |
| SKA2 protein network | https://string-db.org/network/9606.ENSP00000333433 | Spindle and kinetochore-associated protein 2; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Require [...] |
| TREX2 protein network | https://string-db.org/network/9606.ENSP00000333441 | Three prime repair exonuclease 2; Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair; Belongs to the exonuclease superfamily. TREX fam [...] |
| MAGEA2B protein network | https://string-db.org/network/9606.ENSP00000333487 | Melanoma antigen family A, 2B; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiqui [...] |
| URAD protein network | https://string-db.org/network/9606.ENSP00000333490 | Putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; Catalyzes the stereoselective decarboxylation of 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin |
| KCND2 protein network | https://string-db.org/network/9606.ENSP00000333496 | Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the [...] |
| SLC24A3 protein network | https://string-db.org/network/9606.ENSP00000333519 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers |
| CYP2F1 protein network | https://string-db.org/network/9606.ENSP00000333534 | Cytochrome P450 2F1; May be involved in the metabolism of various pneumotoxicants including naphthalene. Is able to dealkylate ethoxycoumarin, propoxycoumarin, and pentoxyresorufin but possesses [...] |
| MIPOL1 protein network | https://string-db.org/network/9606.ENSP00000333539 | Mirror-image polydactyly 1 |
| RAB11B protein network | https://string-db.org/network/9606.ENSP00000333547 | Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle be [...] |
| PROSC protein network | https://string-db.org/network/9606.ENSP00000333551 | Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active fo [...] |
| PRKD1 protein network | https://string-db.org/network/9606.ENSP00000333568 | Serine/threonine-protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in [...] |
| SLC35D3 protein network | https://string-db.org/network/9606.ENSP00000333591 | Solute carrier family 35 member D3; May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules; Solute carriers |
| NXPH4 protein network | https://string-db.org/network/9606.ENSP00000333593 | Neurexophilin-4; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors; Belongs to the neurexophilin family |
| MTA1 protein network | https://string-db.org/network/9606.ENSP00000333633 | Metastasis-associated protein MTA1; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuR [...] |
| IFNL2 protein network | https://string-db.org/network/9606.ENSP00000333639 | Interferon lambda-2; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...] |
| EYA2 protein network | https://string-db.org/network/9606.ENSP00000333640 | Eyes absent homolog 2; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Ty [...] |
| MX2 protein network | https://string-db.org/network/9606.ENSP00000333657 | Interferon-induced GTP-binding protein Mx2; Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral [...] |
| ZNF571 protein network | https://string-db.org/network/9606.ENSP00000333660 | Zinc finger protein 571; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ACAA1 protein network | https://string-db.org/network/9606.ENSP00000333664 | 3-ketoacyl-CoA thiolase, peroxisomal; acetyl-CoA acyltransferase 1 |
| ADI1 protein network | https://string-db.org/network/9606.ENSP00000333666 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also [...] |
| SHMT2 protein network | https://string-db.org/network/9606.ENSP00000333667 | Serine hydroxymethyltransferase, mitochondrial; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate bios [...] |
| NFAM1 protein network | https://string-db.org/network/9606.ENSP00000333680 | NFAT activation molecule 1; May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcript [...] |
| MAPK11 protein network | https://string-db.org/network/9606.ENSP00000333685 | Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an [...] |
| TMEM179B protein network | https://string-db.org/network/9606.ENSP00000333697 | Transmembrane protein 179B; Belongs to the TMEM179 family |
| OR6X1 protein network | https://string-db.org/network/9606.ENSP00000333724 | Olfactory receptor 6X1; Odorant receptor; Olfactory receptors, family 6 |
| ZNF26 protein network | https://string-db.org/network/9606.ENSP00000333725 | Zinc finger protein 26; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NPAP1 protein network | https://string-db.org/network/9606.ENSP00000333735 | Nuclear pore-associated protein 1; May be involved in spermatogenesis |
| BSG protein network | https://string-db.org/network/9606.ENSP00000333769 | Basigin; Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8 and SLC16A11 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implan [...] |
| ZNF479 protein network | https://string-db.org/network/9606.ENSP00000333776 | Zinc finger protein 479; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| EVI2B protein network | https://string-db.org/network/9606.ENSP00000333779 | Protein EVI2B; Required for granulocyte differentiation and functionality of hematopoietic progenitor cells through the control of cell cycle progression and survival of hematopoietic progenitor [...] |
| MRGPRX2 protein network | https://string-db.org/network/9606.ENSP00000333800 | Mas-related G-protein coupled receptor member X2; Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a bas [...] |
| ZNF599 protein network | https://string-db.org/network/9606.ENSP00000333802 | Zinc finger protein 599; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ALG12 protein network | https://string-db.org/network/9606.ENSP00000333813 | Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP- Man(7)GlcNAc(2 [...] |
| MC2R protein network | https://string-db.org/network/9606.ENSP00000333821 | Adrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP); Belongs to the G-protein coupled r [...] |
| CMTM4 protein network | https://string-db.org/network/9606.ENSP00000333833 | CKLF like MARVEL transmembrane domain containing 4 |
| FIGN protein network | https://string-db.org/network/9606.ENSP00000333836 | Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule [...] |
| MRPL12 protein network | https://string-db.org/network/9606.ENSP00000333837 | 39S ribosomal protein L12, mitochondrial; Associates with mitochondrial RNA polymerase to activate transcription; Belongs to the bacterial ribosomal protein bL12 family |
| C11orf88 protein network | https://string-db.org/network/9606.ENSP00000333845 | UPF0722 protein C11orf88; Chromosome 11 open reading frame 88 |
| KRTAP22-1 protein network | https://string-db.org/network/9606.ENSP00000333887 | Keratin-associated protein 22-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| RPS6KA4 protein network | https://string-db.org/network/9606.ENSP00000333896 | Ribosomal protein S6 kinase alpha-4; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the reg [...] |
| OIT3 protein network | https://string-db.org/network/9606.ENSP00000333900 | Oncoprotein-induced transcript 3 protein; May be involved in hepatocellular function and development |
| CCDC42B protein network | https://string-db.org/network/9606.ENSP00000333915 | Cilia- and flagella-associated protein 73; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm |
| DUSP18 protein network | https://string-db.org/network/9606.ENSP00000333917 | Dual specificity protein phosphatase 18; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphoth [...] |
| BTLA protein network | https://string-db.org/network/9606.ENSP00000333919 | B- and T-lymphocyte attenuator; Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response; CD molecules |
| TTF1 protein network | https://string-db.org/network/9606.ENSP00000333920 | Transcription termination factor 1; Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription o [...] |
| ABCC5 protein network | https://string-db.org/network/9606.ENSP00000333926 | Multidrug resistance-associated protein 5; Acts as a multispecific organic anion pump which can transport nucleotide analogs; Belongs to the ABC transporter superfamily. ABCC family. Conjugate tr [...] |
| TRMT11 protein network | https://string-db.org/network/9606.ENSP00000333934 | tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotid [...] |
| NEXN protein network | https://string-db.org/network/9606.ENSP00000333938 | Nexilin; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity; I-set domain containing |
| KIF9 protein network | https://string-db.org/network/9606.ENSP00000333942 | Kinesin-like protein KIF9; Kinesin family member 9; Kinesins |
| COQ6 protein network | https://string-db.org/network/9606.ENSP00000333946 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-poly [...] |
| RPS19BP1 protein network | https://string-db.org/network/9606.ENSP00000333948 | Active regulator of SIRT1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity; Belongs [...] |
| LCE5A protein network | https://string-db.org/network/9606.ENSP00000333952 | Late cornified envelope protein 5A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| SELV protein network | https://string-db.org/network/9606.ENSP00000333956 | May be involved in a redox-related process |
| ZNF749 protein network | https://string-db.org/network/9606.ENSP00000333980 | Zinc finger protein 749; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NDEL1 protein network | https://string-db.org/network/9606.ENSP00000333982 | Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least i [...] |
| KRTAP17-1 protein network | https://string-db.org/network/9606.ENSP00000333993 | Keratin-associated protein 17-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| HBB protein network | https://string-db.org/network/9606.ENSP00000333994 | Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family |
| HAP1 protein network | https://string-db.org/network/9606.ENSP00000334002 | Huntingtin-associated protein 1; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within [...] |
| INTU protein network | https://string-db.org/network/9606.ENSP00000334003 | Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of [...] |
| PARVA protein network | https://string-db.org/network/9606.ENSP00000334008 | Alpha-parvin; Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the [...] |
| EMC10 protein network | https://string-db.org/network/9606.ENSP00000334037 | ER membrane protein complex subunit 10; Belongs to the EMC10 family |
| RSBN1L protein network | https://string-db.org/network/9606.ENSP00000334040 | Round spermatid basic protein 1 like |
| TAC4 protein network | https://string-db.org/network/9606.ENSP00000334042 | Tachykinin-4; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscle [...] |
| UBL4B protein network | https://string-db.org/network/9606.ENSP00000334044 | Ubiquitin-like protein 4B; Ubiquitin like 4B |
| TAS2R42 protein network | https://string-db.org/network/9606.ENSP00000334050 | Taste receptor type 2 member 42; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| GNAL protein network | https://string-db.org/network/9606.ENSP00000334051 | Guanine nucleotide-binding protein G(olf) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(o [...] |
| HDAC6 protein network | https://string-db.org/network/9606.ENSP00000334061 | Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| OR13C8 protein network | https://string-db.org/network/9606.ENSP00000334068 | Olfactory receptor 13C8; Odorant receptor; Olfactory receptors, family 13 |
| TMEM212 protein network | https://string-db.org/network/9606.ENSP00000334072 | Transmembrane protein 212 |
| EXOC7 protein network | https://string-db.org/network/9606.ENSP00000334100 | Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeti [...] |
| DHRSX protein network | https://string-db.org/network/9606.ENSP00000334113 | Dehydrogenase/reductase SDR family member on chromosome X; Involved in the positive regulation of starvation- induced autophagy; Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| OR10T2 protein network | https://string-db.org/network/9606.ENSP00000334115 | Olfactory receptor 10T2; Odorant receptor; Olfactory receptors, family 10 |
| FGF3 protein network | https://string-db.org/network/9606.ENSP00000334122 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development; Belongs to the h [...] |
| CYP27C1 protein network | https://string-db.org/network/9606.ENSP00000334128 | Cytochrome P450 27C1; Catalyzes the conversion of all-trans retinol (also called vitamin A1, the precursor of 11-cis retinal) to 3,4- didehydroretinol (also called vitamin A2, the precursor of 11 [...] |
| RGS9BP protein network | https://string-db.org/network/9606.ENSP00000334134 | Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via it [...] |
| KLHDC10 protein network | https://string-db.org/network/9606.ENSP00000334140 | Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5 |
| F3 protein network | https://string-db.org/network/9606.ENSP00000334145 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a rol [...] |
| WDR25 protein network | https://string-db.org/network/9606.ENSP00000334148 | WD repeat-containing protein 25; WD repeat domain containing |
| RFTN1 protein network | https://string-db.org/network/9606.ENSP00000334153 | Raftlin; May play a pivotal role in the formation and/or maintenance of lipid rafts. May regulate B-cell antigen receptor- mediated signaling |
| SPIN4 protein network | https://string-db.org/network/9606.ENSP00000334163 | Spindlin-4; Exhibits H3K4me3-binding activity; Spindlin family |
| KDM4D protein network | https://string-db.org/network/9606.ENSP00000334181 | Lysine-specific demethylase 4D; Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', [...] |
| VWCE protein network | https://string-db.org/network/9606.ENSP00000334186 | Von Willebrand factor C and EGF domain-containing protein; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma |
| LCE1F protein network | https://string-db.org/network/9606.ENSP00000334187 | Late cornified envelope protein 1F; Precursors of the cornified envelope of the stratum corneum |
| KRTAP10-11 protein network | https://string-db.org/network/9606.ENSP00000334197 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| CACNA1H protein network | https://string-db.org/network/9606.ENSP00000334198 | Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| ATP4B protein network | https://string-db.org/network/9606.ENSP00000334216 | Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial [...] |
| SLC36A2 protein network | https://string-db.org/network/9606.ENSP00000334223 | Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine [...] |
| CYP4Z1 protein network | https://string-db.org/network/9606.ENSP00000334246 | Cytochrome P450 family 4 subfamily Z member 1 |
| C5orf38 protein network | https://string-db.org/network/9606.ENSP00000334267 | Protein CEI; Chromosome 5 open reading frame 38 |
| UGT2B28 protein network | https://string-db.org/network/9606.ENSP00000334276 | UDP-glucuronosyltransferase 2B28; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuron [...] |
| KRTAP21-2 protein network | https://string-db.org/network/9606.ENSP00000334287 | Keratin-associated protein 21-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| C9orf85 protein network | https://string-db.org/network/9606.ENSP00000334289 | Uncharacterized protein C9orf85; Chromosome 9 open reading frame 85 |
| TCFL5 protein network | https://string-db.org/network/9606.ENSP00000334294 | Transcription factor-like 5 protein; Putative transcription factor. Isoform 3 may play a role in early spermatogenesis; Basic helix-loop-helix proteins |
| ACTL7A protein network | https://string-db.org/network/9606.ENSP00000334300 | Actin-like protein 7A; Actin related proteins; Belongs to the actin family |
| SYNE3 protein network | https://string-db.org/network/9606.ENSP00000334308 | Nesprin-3; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interac [...] |
| EML1 protein network | https://string-db.org/network/9606.ENSP00000334314 | Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic s [...] |
| PCLO protein network | https://string-db.org/network/9606.ENSP00000334319 | Protein piccolo; May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking; C2 domain containing |
| UNC5B protein network | https://string-db.org/network/9606.ENSP00000334329 | Netrin receptor UNC5B; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in gro [...] |
| DEFB105A protein network | https://string-db.org/network/9606.ENSP00000334330 | Defensin, beta 105A; Has antibacterial activity; Defensins, beta |
| DEFB106B protein network | https://string-db.org/network/9606.ENSP00000334364 | Defensin, beta 106B; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2; Belongs to the beta-defensin family |
| KPNA4 protein network | https://string-db.org/network/9606.ENSP00000334373 | Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| LRCH3 protein network | https://string-db.org/network/9606.ENSP00000334375 | Leucine rich repeats and calponin homology domain containing 3 |
| C2CD3 protein network | https://string-db.org/network/9606.ENSP00000334379 | C2 domain-containing protein 3; Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal [...] |
| HOMER1 protein network | https://string-db.org/network/9606.ENSP00000334382 | Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...] |
| OR4F5 protein network | https://string-db.org/network/9606.ENSP00000334393 | Olfactory receptor 4F5; Odorant receptor; Olfactory receptors, family 4 |
| PRAMEF14 protein network | https://string-db.org/network/9606.ENSP00000334410 | PRAME family member 14 |
| FAM183A protein network | https://string-db.org/network/9606.ENSP00000334415 | Protein FAM183A; Family with sequence similarity 183 member A; Belongs to the FAM183 family |
| OR4C12 protein network | https://string-db.org/network/9606.ENSP00000334418 | Olfactory receptor 4C12; Odorant receptor; Olfactory receptors, family 4 |
| FAM9C protein network | https://string-db.org/network/9606.ENSP00000334430 | Protein FAM9C; Family with sequence similarity 9 member C |
| NUDT17 protein network | https://string-db.org/network/9606.ENSP00000334437 | Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family |
| OR10J5 protein network | https://string-db.org/network/9606.ENSP00000334441 | Olfactory receptor 10J5; Odorant receptor; Olfactory receptors, family 10 |
| GNG2 protein network | https://string-db.org/network/9606.ENSP00000334448 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| OR13F1 protein network | https://string-db.org/network/9606.ENSP00000334452 | Olfactory receptor 13F1; Odorant receptor; Olfactory receptors, family 13 |
| OR5D14 protein network | https://string-db.org/network/9606.ENSP00000334456 | Olfactory receptor 5D14; Odorant receptor; Olfactory receptors, family 5 |
| GATA4 protein network | https://string-db.org/network/9606.ENSP00000334458 | Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it bin [...] |
| LYPD6 protein network | https://string-db.org/network/9606.ENSP00000334463 | Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs. Acts as a p [...] |
| FOXE3 protein network | https://string-db.org/network/9606.ENSP00000334472 | Forkhead box protein E3; Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle. During lens development, controls the ratio [...] |
| ZMIZ1 protein network | https://string-db.org/network/9606.ENSP00000334474 | Zinc finger MIZ domain-containing protein 1; Acts as transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR act [...] |
| DMRTC1B protein network | https://string-db.org/network/9606.ENSP00000334501 | DMRT like family C1B; Belongs to the DMRT family |
| SREK1 protein network | https://string-db.org/network/9606.ENSP00000334538 | Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SF [...] |
| TAL2 protein network | https://string-db.org/network/9606.ENSP00000334547 | T-cell acute lymphocytic leukemia protein 2; Basic helix-loop-helix proteins |
| PPIL2 protein network | https://string-db.org/network/9606.ENSP00000334553 | Peptidyl-prolyl cis-trans isomerase-like 2; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). Ma [...] |
| KRTAP6-2 protein network | https://string-db.org/network/9606.ENSP00000334560 | Keratin-associated protein 6-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| MYO18B protein network | https://string-db.org/network/9606.ENSP00000334563 | Unconventional myosin-XVIIIb; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle spec [...] |
| POLR3C protein network | https://string-db.org/network/9606.ENSP00000334564 | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core com [...] |
| CYP2R1 protein network | https://string-db.org/network/9606.ENSP00000334592 | Vitamin D 25-hydroxylase; Has a D-25-hydroxylase activity on both forms of vitamin D, vitamin D(2) and D(3); Cytochrome P450 family 2 |
| TMPRSS11A protein network | https://string-db.org/network/9606.ENSP00000334611 | Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest |
| PDZD8 protein network | https://string-db.org/network/9606.ENSP00000334642 | PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8- dependent endoplasmic reticulum-mitochondria membrane tethering [...] |
| LCE3C protein network | https://string-db.org/network/9606.ENSP00000334644 | Late cornified envelope protein 3C; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| KCNK18 protein network | https://string-db.org/network/9606.ENSP00000334650 | Potassium channel subfamily K member 18; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets [...] |
| TRIM46 protein network | https://string-db.org/network/9606.ENSP00000334657 | Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for [...] |
| FSCN2 protein network | https://string-db.org/network/9606.ENSP00000334665 | Fascin-2; Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis; Fascins |
| ERCC6L protein network | https://string-db.org/network/9606.ENSP00000334675 | DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetocho [...] |
| DEFB107A protein network | https://string-db.org/network/9606.ENSP00000334681 | Defensin, beta 107A; Has antibacterial activity; Defensins, beta |
| KRTAP19-7 protein network | https://string-db.org/network/9606.ENSP00000334696 | Keratin-associated protein 19-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| IGFN1 protein network | https://string-db.org/network/9606.ENSP00000334714 | Immunoglobulin-like and fibronectin type III domain containing 1 |
| OR6P1 protein network | https://string-db.org/network/9606.ENSP00000334721 | Olfactory receptor 6P1; Odorant receptor; Olfactory receptors, family 6 |
| CCDC84 protein network | https://string-db.org/network/9606.ENSP00000334767 | Coiled-coil domain containing 84 |
| TESC protein network | https://string-db.org/network/9606.ENSP00000334785 | Calcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, c [...] |
| KRT26 protein network | https://string-db.org/network/9606.ENSP00000334798 | Keratin, type I cytoskeletal 26; Keratins, type I; Belongs to the intermediate filament family |
| DHRS4L2 protein network | https://string-db.org/network/9606.ENSP00000334801 | Dehydrogenase/reductase SDR family member 4-like 2; Probable oxidoreductase; Short chain dehydrogenase/reductase superfamily |
| H1FNT protein network | https://string-db.org/network/9606.ENSP00000334805 | Testis-specific H1 histone; Essential for normal spermatogenesis and male fertility. Required for proper cell restructuring and DNA condensation during the elongation phase of spermiogenesis. Inv [...] |
| USP16 protein network | https://string-db.org/network/9606.ENSP00000334808 | Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactiva [...] |
| RAX protein network | https://string-db.org/network/9606.ENSP00000334813 | Retinal homeobox protein Rx; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor cons [...] |
| KRTAP13-4 protein network | https://string-db.org/network/9606.ENSP00000334834 | Keratin-associated protein 13-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| BMP2K protein network | https://string-db.org/network/9606.ENSP00000334836 | BMP-2-inducible protein kinase; May be involved in osteoblast differentiation |
| PNRC2 protein network | https://string-db.org/network/9606.ENSP00000334840 | Proline-rich nuclear receptor coactivator 2; Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting th [...] |
| TMEM104 protein network | https://string-db.org/network/9606.ENSP00000334849 | Transmembrane protein 104; Belongs to the TMEM104 family |
| RGS7BP protein network | https://string-db.org/network/9606.ENSP00000334851 | Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellula [...] |
| ZNF555 protein network | https://string-db.org/network/9606.ENSP00000334853 | Zinc finger protein 555; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZACN protein network | https://string-db.org/network/9606.ENSP00000334854 | Zinc-activated ligand-gated ion channel; Zinc-activated ligand-gated ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family |
| KRTAP15-1 protein network | https://string-db.org/network/9606.ENSP00000334866 | Keratin-associated protein 15-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| LCE1A protein network | https://string-db.org/network/9606.ENSP00000334869 | Late cornified envelope protein 1A; Precursors of the cornified envelope of the stratum corneum |
| MT1F protein network | https://string-db.org/network/9606.ENSP00000334872 | Metallothionein-1F; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| GRK1 protein network | https://string-db.org/network/9606.ENSP00000334876 | Rhodopsin kinase; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This [...] |
| SOWAHB protein network | https://string-db.org/network/9606.ENSP00000334879 | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family |
| PDE2A protein network | https://string-db.org/network/9606.ENSP00000334910 | cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important phy [...] |
| KRTAP9-4 protein network | https://string-db.org/network/9606.ENSP00000334922 | Keratin-associated protein 9-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| PTPRB protein network | https://string-db.org/network/9606.ENSP00000334928 | Receptor-type tyrosine-protein phosphatase beta; Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential fo [...] |
| OR9Q1 protein network | https://string-db.org/network/9606.ENSP00000334934 | Olfactory receptor 9Q1; Odorant receptor; Olfactory receptors, family 9 |
| GGN protein network | https://string-db.org/network/9606.ENSP00000334940 | Gametogenetin; May be involved in spermatogenesis |
| PTPRU protein network | https://string-db.org/network/9606.ENSP00000334941 | Receptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proli [...] |
| GPR125 protein network | https://string-db.org/network/9606.ENSP00000334952 | Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled recept [...] |
| RLTPR protein network | https://string-db.org/network/9606.ENSP00000334958 | Capping protein, Arp2/3 and myosin-I linker protein 2; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filamen [...] |
| C3orf70 protein network | https://string-db.org/network/9606.ENSP00000334974 | UPF0524 protein C3orf70; Chromosome 3 open reading frame 70; Belongs to the UPF0524 family |
| KRTAP19-5 protein network | https://string-db.org/network/9606.ENSP00000334985 | Keratin-associated protein 19-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| CCIN protein network | https://string-db.org/network/9606.ENSP00000334996 | Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation; BTB domain containing |
| MT1B protein network | https://string-db.org/network/9606.ENSP00000334998 | Metallothionein-1B; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| LCE3A protein network | https://string-db.org/network/9606.ENSP00000335006 | Late cornified envelope protein 3A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| SPIN2B protein network | https://string-db.org/network/9606.ENSP00000335008 | Spindlin-2B; Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors. Exhibits H3K4me3-bind [...] |
| PRR30 protein network | https://string-db.org/network/9606.ENSP00000335017 | Proline-rich protein 30; Proline rich 30 |
| SERPINA11 protein network | https://string-db.org/network/9606.ENSP00000335024 | Serpin peptidase inhibitors |
| OR5D18 protein network | https://string-db.org/network/9606.ENSP00000335025 | Olfactory receptor 5D18; Odorant receptor; Olfactory receptors, family 5 |
| RASA3 protein network | https://string-db.org/network/9606.ENSP00000335029 | Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor; C2 and RasGAP dom [...] |
| VSTM2B protein network | https://string-db.org/network/9606.ENSP00000335038 | V-set and transmembrane domain containing 2B |
| FAM129C protein network | https://string-db.org/network/9606.ENSP00000335040 | Niban-like protein 2; Family with sequence similarity 129 member C; Belongs to the Niban family |
| ZNF486 protein network | https://string-db.org/network/9606.ENSP00000335042 | Zinc finger protein 486; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ARID2 protein network | https://string-db.org/network/9606.ENSP00000335044 | AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required fo [...] |
| WASF3 protein network | https://string-db.org/network/9606.ENSP00000335055 | Wiskott-Aldrich syndrome protein family member 3; Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...] |
| HPDL protein network | https://string-db.org/network/9606.ENSP00000335060 | 4-hydroxyphenylpyruvate dioxygenase-like protein; May have dioxygenase activity |
| PDCD1 protein network | https://string-db.org/network/9606.ENSP00000335062 | Programmed cell death protein 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functi [...] |
| GHRL protein network | https://string-db.org/network/9606.ENSP00000335074 | Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating ef [...] |
| EDARADD protein network | https://string-db.org/network/9606.ENSP00000335076 | Ectodysplasin-A receptor-associated adapter protein; Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal org [...] |
| FAM91A1 protein network | https://string-db.org/network/9606.ENSP00000335082 | Protein FAM91A1; Family with sequence similarity 91 member A1; Belongs to the FAM91 family |
| PPP2R2C protein network | https://string-db.org/network/9606.ENSP00000335083 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...] |
| ZNRF1 protein network | https://string-db.org/network/9606.ENSP00000335091 | E3 ubiquitin-protein ligase ZNRF1; E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the estab [...] |
| TMEM17 protein network | https://string-db.org/network/9606.ENSP00000335094 | Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of tran [...] |
| ANKRD37 protein network | https://string-db.org/network/9606.ENSP00000335147 | Ankyrin repeat domain-containing protein 37; Ankyrin repeat domain containing |
| HSP90AA1 protein network | https://string-db.org/network/9606.ENSP00000335153 | Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle con [...] |
| GPR144 protein network | https://string-db.org/network/9606.ENSP00000335156 | Adhesion G-protein coupled receptor D2; Orphan receptor |
| GPR142 protein network | https://string-db.org/network/9606.ENSP00000335158 | Probable G-protein coupled receptor 142; Orphan receptor; G protein-coupled receptors, Class A orphans |
| TBX10 protein network | https://string-db.org/network/9606.ENSP00000335191 | T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes; T-boxes |
| VPS39 protein network | https://string-db.org/network/9606.ENSP00000335193 | Vam6/Vps39-like protein; Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this woul [...] |
| GLDN protein network | https://string-db.org/network/9606.ENSP00000335196 | Gliomedin; Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvi [...] |
| BCDIN3D protein network | https://string-db.org/network/9606.ENSP00000335201 | Pre-miRNA 5'-monophosphate methyltransferase; O-methyltransferase that specifically dimethylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' mon [...] |
| ATPIF1 protein network | https://string-db.org/network/9606.ENSP00000335203 | ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts [...] |
| C17orf82 protein network | https://string-db.org/network/9606.ENSP00000335229 | Putative uncharacterized protein C17orf82; Chromosome 17 open reading frame 82 |
| ENTPD5 protein network | https://string-db.org/network/9606.ENSP00000335246 | Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation a [...] |
| STARD10 protein network | https://string-db.org/network/9606.ENSP00000335247 | START domain-containing protein 10; May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containi [...] |
| ANGPTL5 protein network | https://string-db.org/network/9606.ENSP00000335255 | Angiopoietin-related protein 5; Fibrinogen C domain containing; Angiopoietin like |
| TMLHE protein network | https://string-db.org/network/9606.ENSP00000335261 | Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML); Belongs to the gamma-BBH/TMLD family |
| DEFB105B protein network | https://string-db.org/network/9606.ENSP00000335281 | Beta-defensin 105; Has antibacterial activity; Defensins, beta |
| C1QL4 protein network | https://string-db.org/network/9606.ENSP00000335285 | Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte d [...] |
| SLC51B protein network | https://string-db.org/network/9606.ENSP00000335292 | Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export [...] |
| DLST protein network | https://string-db.org/network/9606.ENSP00000335304 | Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and C [...] |
| DPPA4 protein network | https://string-db.org/network/9606.ENSP00000335306 | Developmental pluripotency-associated protein 4; May be involved in the maintenance of active epigenetic status of target genes. May inhibit differentiation of embryonic cells into a primitive ec [...] |
| DEFB106A protein network | https://string-db.org/network/9606.ENSP00000335307 | Beta-defensin 106; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2; Belongs to the beta-defensin family |
| BCL9L protein network | https://string-db.org/network/9606.ENSP00000335320 | B-cell CLL/lymphoma 9-like protein; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic tra [...] |
| SF3B1 protein network | https://string-db.org/network/9606.ENSP00000335321 | Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| CCDC73 protein network | https://string-db.org/network/9606.ENSP00000335325 | Coiled-coil domain containing 73 |
| CDKN3 protein network | https://string-db.org/network/9606.ENSP00000335357 | Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. D [...] |
| LCE3B protein network | https://string-db.org/network/9606.ENSP00000335358 | Late cornified envelope protein 3B; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| TRAPPC11 protein network | https://string-db.org/network/9606.ENSP00000335371 | Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Trafficking protein particle complex |
| DEFB128 protein network | https://string-db.org/network/9606.ENSP00000335382 | Beta-defensin 128; Has antibacterial activity; Defensins, beta |
| ZPBP2 protein network | https://string-db.org/network/9606.ENSP00000335384 | Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization; Immunoglobulin like domain containing |
| SPATA12 protein network | https://string-db.org/network/9606.ENSP00000335392 | Spermatogenesis-associated protein 12; Spermatogenesis associated 12 |
| RTN4RL2 protein network | https://string-db.org/network/9606.ENSP00000335397 | Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant [...] |
| ZNF20 protein network | https://string-db.org/network/9606.ENSP00000335437 | Zinc finger protein 20; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CASC5 protein network | https://string-db.org/network/9606.ENSP00000335463 | Kinetochore scaffold 1; Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of t [...] |
| EMID1 protein network | https://string-db.org/network/9606.ENSP00000335481 | EMI domain containing 1 |
| FOXD2 protein network | https://string-db.org/network/9606.ENSP00000335493 | Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis; Forkhead boxes |
| C7orf57 protein network | https://string-db.org/network/9606.ENSP00000335500 | Uncharacterized protein C7orf57; Chromosome 7 open reading frame 57 |
| KRTAP20-1 protein network | https://string-db.org/network/9606.ENSP00000335503 | Keratin-associated protein 20-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| OR5L1 protein network | https://string-db.org/network/9606.ENSP00000335529 | Olfactory receptor 5L1; Odorant receptor; Olfactory receptors, family 5 |
| OR6N1 protein network | https://string-db.org/network/9606.ENSP00000335535 | Olfactory receptor 6N1; Odorant receptor; Olfactory receptors, family 6 |
| DEFB131 protein network | https://string-db.org/network/9606.ENSP00000335538 | Beta-defensin 131A; Has antibacterial activity (Probable). Upon stimulation with lipoteichoic acid, promotes cytokines and chemokines production and secretion; Belongs to the beta-defensin family |
| CCKBR protein network | https://string-db.org/network/9606.ENSP00000335544 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, [...] |
| SLX4IP protein network | https://string-db.org/network/9606.ENSP00000335557 | SLX4 interacting protein |
| ARHGEF25 protein network | https://string-db.org/network/9606.ENSP00000335560 | Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a g [...] |
| KRTAP10-8 protein network | https://string-db.org/network/9606.ENSP00000335565 | Keratin-associated protein 10-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP21-1 protein network | https://string-db.org/network/9606.ENSP00000335566 | Keratin-associated protein 21-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP19-4 protein network | https://string-db.org/network/9606.ENSP00000335567 | Keratin-associated protein 19-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| OR1J2 protein network | https://string-db.org/network/9606.ENSP00000335575 | Olfactory receptor 1J2; Odorant receptor; Olfactory receptors, family 1 |
| ARGFX protein network | https://string-db.org/network/9606.ENSP00000335578 | Arginine-fifty homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes |
| GABRA5 protein network | https://string-db.org/network/9606.ENSP00000335592 | Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| TCP11L1 protein network | https://string-db.org/network/9606.ENSP00000335595 | T-complex protein 11-like protein 1; T-complex 11 like 1 |
| OR10H1 protein network | https://string-db.org/network/9606.ENSP00000335596 | Olfactory receptor 10H1; Odorant receptor; Olfactory receptors, family 10 |
| CMTM7 protein network | https://string-db.org/network/9606.ENSP00000335605 | CKLF like MARVEL transmembrane domain containing 7; Belongs to the chemokine-like factor family |
| SPATA21 protein network | https://string-db.org/network/9606.ENSP00000335612 | Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids; EF-hand domain containing |
| PPFIA3 protein network | https://string-db.org/network/9606.ENSP00000335614 | Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their inter [...] |
| BTBD7 protein network | https://string-db.org/network/9606.ENSP00000335615 | BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, [...] |
| GSTA1 protein network | https://string-db.org/network/9606.ENSP00000335620 | Glutathione S-transferase A1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family |
| VSIG10L protein network | https://string-db.org/network/9606.ENSP00000335623 | V-set and immunoglobulin domain containing 10 like |
| SPDYA protein network | https://string-db.org/network/9606.ENSP00000335628 | Speedy protein A; Regulates the G1/S phase transition of the cell cycle by binding and activating CDK1 and CDK2. Contributes to CDK2 activation without promoting CDK2 phosphorylation, by inducing [...] |
| CHP1 protein network | https://string-db.org/network/9606.ENSP00000335632 | Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcriptio [...] |
| NAA20 protein network | https://string-db.org/network/9606.ENSP00000335636 | N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met- [...] |
| FSD2 protein network | https://string-db.org/network/9606.ENSP00000335651 | Fibronectin type III and SPRY domain containing 2 |
| FMNL3 protein network | https://string-db.org/network/9606.ENSP00000335655 | Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesi [...] |
| KRTAP19-2 protein network | https://string-db.org/network/9606.ENSP00000335660 | Keratin-associated protein 19-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| PRELID2 protein network | https://string-db.org/network/9606.ENSP00000335675 | PRELI domain containing 2 |
| FOXK2 protein network | https://string-db.org/network/9606.ENSP00000335677 | Forkhead box protein K2; Transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Positively regulates WNT/beta- cate [...] |
| FAM192A protein network | https://string-db.org/network/9606.ENSP00000335808 | Protein FAM192A; Family with sequence similarity 192 member A |
| TTC7B protein network | https://string-db.org/network/9606.ENSP00000336127 | Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinosit [...] |
| CEP63 protein network | https://string-db.org/network/9606.ENSP00000336524 | Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and [...] |
| NR1I2 protein network | https://string-db.org/network/9606.ENSP00000336528 | Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcriptio [...] |
| CDR2L protein network | https://string-db.org/network/9606.ENSP00000336587 | Cerebellar degeneration related protein 2 like |
| RAD54B protein network | https://string-db.org/network/9606.ENSP00000336606 | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epista [...] |
| ADORA2A protein network | https://string-db.org/network/9606.ENSP00000336630 | Adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family |
| STRADA protein network | https://string-db.org/network/9606.ENSP00000336655 | STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation ty [...] |
| LRRC71 protein network | https://string-db.org/network/9606.ENSP00000336661 | Leucine-rich repeat-containing protein 71; Leucine rich repeat containing 71 |
| AP1S1 protein network | https://string-db.org/network/9606.ENSP00000336666 | AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP c [...] |
| CBX3 protein network | https://string-db.org/network/9606.ENSP00000336687 | Chromobox protein homolog 3; Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigeneti [...] |
| ABHD12B protein network | https://string-db.org/network/9606.ENSP00000336693 | Belongs to the serine esterase family |
| RAD51C protein network | https://string-db.org/network/9606.ENSP00000336701 | DNA repair protein RAD51 homolog 3; Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA bre [...] |
| EIF5A protein network | https://string-db.org/network/9606.ENSP00000336702 | Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of deca [...] |
| TNPO1 protein network | https://string-db.org/network/9606.ENSP00000336712 | Transportin-1; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of t [...] |
| LARP1 protein network | https://string-db.org/network/9606.ENSP00000336721 | La-related protein 1; RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. Associates with the mRNA 5'cap in an MTOR-dependent manner and a [...] |
| TBC1D22A protein network | https://string-db.org/network/9606.ENSP00000336724 | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s) |
| GALNT16 protein network | https://string-db.org/network/9606.ENSP00000336729 | Polypeptide N-acetylgalactosaminyltransferase 16; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| ST6GALNAC4 protein network | https://string-db.org/network/9606.ENSP00000336733 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alp [...] |
| LIMK1 protein network | https://string-db.org/network/9606.ENSP00000336740 | LIM domain kinase 1; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pa [...] |
| DHX15 protein network | https://string-db.org/network/9606.ENSP00000336741 | Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to [...] |
| HIP1 protein network | https://string-db.org/network/9606.ENSP00000336747 | Huntingtin-interacting protein 1; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependen [...] |
| SUPT7L protein network | https://string-db.org/network/9606.ENSP00000336750 | SPT7 like, STAGA complex gamma subunit |
| FIP1L1 protein network | https://string-db.org/network/9606.ENSP00000336752 | Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA [...] |
| ANG protein network | https://string-db.org/network/9606.ENSP00000336762 | Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing [...] |
| OPRL1 protein network | https://string-db.org/network/9606.ENSP00000336764 | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling v [...] |
| KIR2DL1 protein network | https://string-db.org/network/9606.ENSP00000336769 | Killer cell immunoglobulin-like receptor 2DL1; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules |
| SYNM protein network | https://string-db.org/network/9606.ENSP00000336775 | Synemin; Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its i [...] |
| TNRC6C protein network | https://string-db.org/network/9606.ENSP00000336783 | Trinucleotide repeat-containing gene 6C protein; Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs [...] |
| ATF4 protein network | https://string-db.org/network/9606.ENSP00000336790 | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular [...] |
| TUBA1B protein network | https://string-db.org/network/9606.ENSP00000336799 | Tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| KLHL25 protein network | https://string-db.org/network/9606.ENSP00000336800 | Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by med [...] |
| LUZP2 protein network | https://string-db.org/network/9606.ENSP00000336817 | Leucine zipper protein 2 |
| FGG protein network | https://string-db.org/network/9606.ENSP00000336829 | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary co [...] |
| PLS1 protein network | https://string-db.org/network/9606.ENSP00000336831 | Plastin-1; Actin-bundling protein in the absence of calcium; EF-hand domain containing |
| ACTR8 protein network | https://string-db.org/network/9606.ENSP00000336842 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. [...] |
| IQCH protein network | https://string-db.org/network/9606.ENSP00000336861 | IQ domain-containing protein H; May play a regulatory role in spermatogenesis |
| RBBP9 protein network | https://string-db.org/network/9606.ENSP00000336866 | Putative hydrolase RBBP9; May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta1 through interaction with retinoblast [...] |
| CENPA protein network | https://string-db.org/network/9606.ENSP00000336868 | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric ch [...] |
| SLC39A9 protein network | https://string-db.org/network/9606.ENSP00000336887 | Zinc transporter ZIP9; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family |
| SLC44A2 protein network | https://string-db.org/network/9606.ENSP00000336888 | Choline transporter-like protein 2; Isoform 1, but not isoform 3, exhibits some choline transporter activity; Solute carriers |
| NAB1 protein network | https://string-db.org/network/9606.ENSP00000336894 | NGFI-A-binding protein 1; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2 |
| ARHGAP10 protein network | https://string-db.org/network/9606.ENSP00000336923 | Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organizat [...] |
| PNRC1 protein network | https://string-db.org/network/9606.ENSP00000336931 | Proline-rich nuclear receptor coactivator 1; Nuclear receptor coactivator. May play a role in signal transduction |
| HORMAD2 protein network | https://string-db.org/network/9606.ENSP00000336984 | HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the f [...] |
| TMEM155 protein network | https://string-db.org/network/9606.ENSP00000336987 | Transmembrane protein 155 |
| CLPTM1 protein network | https://string-db.org/network/9606.ENSP00000336994 | Cleft lip and palate transmembrane protein 1; May play a role in T-cell development; Belongs to the CLPTM1 family |
| ZNF644 protein network | https://string-db.org/network/9606.ENSP00000337008 | Zinc finger protein 644; May be involved in transcriptional regulation |
| HFE2 protein network | https://string-db.org/network/9606.ENSP00000337014 | Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis; Belongs to the repuls [...] |
| UNC119 protein network | https://string-db.org/network/9606.ENSP00000337040 | Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacte [...] |
| SEL1L protein network | https://string-db.org/network/9606.ENSP00000337053 | Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfol [...] |
| NME1 protein network | https://string-db.org/network/9606.ENSP00000337060 | Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...] |
| CXCL14 protein network | https://string-db.org/network/9606.ENSP00000337065 | C-X-C motif chemokine 14; Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not i [...] |
| ZNF112 protein network | https://string-db.org/network/9606.ENSP00000337081 | Zinc finger protein 112; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MEN1 protein network | https://string-db.org/network/9606.ENSP00000337088 | Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Bi [...] |
| CHAT protein network | https://string-db.org/network/9606.ENSP00000337103 | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase fami [...] |
| ZNF354A protein network | https://string-db.org/network/9606.ENSP00000337122 | Zinc finger protein 354A; Belongs to the krueppel C2H2-type zinc-finger protein family |
| EDN3 protein network | https://string-db.org/network/9606.ENSP00000337128 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands |
| SERPINA9 protein network | https://string-db.org/network/9606.ENSP00000337133 | Serpin A9; Protease inhibitor that inhibits trypsin and trypsin- like serine proteases (in vitro). Inhibits plasmin and thrombin with lower efficiency (in vitro); Belongs to the serpin family |
| ENOX2 protein network | https://string-db.org/network/9606.ENSP00000337146 | Ecto-NOX disulfide-thiol exchanger 2; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the [...] |
| ZFYVE16 protein network | https://string-db.org/network/9606.ENSP00000337159 | Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to [...] |
| EPB41L1 protein network | https://string-db.org/network/9606.ENSP00000337168 | Band 4.1-like protein 1; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channel [...] |
| AZIN1 protein network | https://string-db.org/network/9606.ENSP00000337180 | Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that cou [...] |
| PRPF4B protein network | https://string-db.org/network/9606.ENSP00000337194 | Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF |
| LRAT protein network | https://string-db.org/network/9606.ENSP00000337224 | Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms [...] |
| CDCA4 protein network | https://string-db.org/network/9606.ENSP00000337226 | Cell division cycle-associated protein 4; May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells a [...] |
| KCNE1 protein network | https://string-db.org/network/9606.ENSP00000337255 | Potassium voltage-gated channel subfamily E member 1; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates t [...] |
| ARHGEF1 protein network | https://string-db.org/network/9606.ENSP00000337261 | Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activa [...] |
| CENPQ protein network | https://string-db.org/network/9606.ENSP00000337289 | Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...] |
| SIRT6 protein network | https://string-db.org/network/9606.ENSP00000337332 | NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chrom [...] |
| SLC22A8 protein network | https://string-db.org/network/9606.ENSP00000337335 | Solute carrier family 22 member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transp [...] |
| MED19 protein network | https://string-db.org/network/9606.ENSP00000337340 | Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| TDP1 protein network | https://string-db.org/network/9606.ENSP00000337353 | Tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phospha [...] |
| LIPA protein network | https://string-db.org/network/9606.ENSP00000337354 | Lysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis [...] |
| CECR5 protein network | https://string-db.org/network/9606.ENSP00000337358 | Haloacid dehalogenase-like hydrolase domain-containing 5; Cat eye syndrome chromosome region, candidate 5 |
| ZNF394 protein network | https://string-db.org/network/9606.ENSP00000337363 | Zinc finger protein 394; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF224 protein network | https://string-db.org/network/9606.ENSP00000337368 | Zinc finger protein 224; May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing [...] |
| NLRP3 protein network | https://string-db.org/network/9606.ENSP00000337383 | NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...] |
| UXT protein network | https://string-db.org/network/9606.ENSP00000337393 | Protein UXT; Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chro [...] |
| HYAL3 protein network | https://string-db.org/network/9606.ENSP00000337425 | Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Invol [...] |
| IL17F protein network | https://string-db.org/network/9606.ENSP00000337432 | Interleukin-17F; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the product [...] |
| DACT1 protein network | https://string-db.org/network/9606.ENSP00000337439 | Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways throu [...] |
| NXN protein network | https://string-db.org/network/9606.ENSP00000337443 | Nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a tra [...] |
| ELAC2 protein network | https://string-db.org/network/9606.ENSP00000337445 | Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from pr [...] |
| STARD3 protein network | https://string-db.org/network/9606.ENSP00000337446 | StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes. Creates contact site between the endoplasmic reticul [...] |
| EPHA3 protein network | https://string-db.org/network/9606.ENSP00000337451 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| NIPA1 protein network | https://string-db.org/network/9606.ENSP00000337452 | Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+) (By si [...] |
| WFDC10B protein network | https://string-db.org/network/9606.ENSP00000337466 | Protein WFDC10B; WAP four-disulfide core domain containing |
| ZNF324B protein network | https://string-db.org/network/9606.ENSP00000337473 | Zinc finger protein 324B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FAM60A protein network | https://string-db.org/network/9606.ENSP00000337477 | SIN3-HDAC complex-associated factor; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathw [...] |
| ARL17A protein network | https://string-db.org/network/9606.ENSP00000337478 | ADP ribosylation factor like GTPase 17A; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein traf [...] |
| NRIP2 protein network | https://string-db.org/network/9606.ENSP00000337501 | Nuclear receptor-interacting protein 2; Down-regulates transcriptional activation by nuclear receptors such as NR1F2 |
| FBXO40 protein network | https://string-db.org/network/9606.ENSP00000337510 | F-box only protein 40; Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis; F-boxes other |
| CMTR2 protein network | https://string-db.org/network/9606.ENSP00000337512 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Met [...] |
| SRA1 protein network | https://string-db.org/network/9606.ENSP00000337513 | Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mec [...] |
| ZNF548 protein network | https://string-db.org/network/9606.ENSP00000337555 | Zinc finger protein 548; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DGKH protein network | https://string-db.org/network/9606.ENSP00000337572 | Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathw [...] |
| GGTLC1 protein network | https://string-db.org/network/9606.ENSP00000337587 | Gamma-glutamyltransferase light chain 1; Gamma-glutamyltransferases |
| NIPA2 protein network | https://string-db.org/network/9606.ENSP00000337618 | Magnesium transporter NIPA2; Acts as a selective Mg(2+) transporter; Belongs to the NIPA family |
| RNASEH2B protein network | https://string-db.org/network/9606.ENSP00000337623 | Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the rem [...] |
| SARNP protein network | https://string-db.org/network/9606.ENSP00000337632 | SAP domain-containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment reg [...] |
| PPP2R5E protein network | https://string-db.org/network/9606.ENSP00000337641 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the [...] |
| EBAG9 protein network | https://string-db.org/network/9606.ENSP00000337675 | Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1- beta converting [...] |
| SEC62 protein network | https://string-db.org/network/9606.ENSP00000337688 | Translocation protein SEC62; Required for preprotein translocation |
| MAPK15 protein network | https://string-db.org/network/9606.ENSP00000337691 | Mitogen-activated protein kinase 15; In vitro, phosphorylates MBP; Mitogen-activated protein kinases |
| DCX protein network | https://string-db.org/network/9606.ENSP00000337697 | Neuronal migration protein doublecortin; Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by comp [...] |
| PNPLA2 protein network | https://string-db.org/network/9606.ENSP00000337701 | Patatin-like phospholipase domain-containing protein 2; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase act [...] |
| ARL6 protein network | https://string-db.org/network/9606.ENSP00000337722 | ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would [...] |
| ZNF202 protein network | https://string-db.org/network/9606.ENSP00000337724 | Zinc finger protein 202; Transcriptional repressor that binds to elements found predominantly in genes that participate in lipid metabolism. Among its targets are structural components of lipopro [...] |
| CIDEB protein network | https://string-db.org/network/9606.ENSP00000337731 | Cell death activator CIDE-B; Activates apoptosis |
| RUNDC3B protein network | https://string-db.org/network/9606.ENSP00000337732 | RUN domain containing 3B |
| KLK5 protein network | https://string-db.org/network/9606.ENSP00000337733 | Kallikrein-5; May be involved in desquamation; Belongs to the peptidase S1 family. Kallikrein subfamily |
| ISYNA1 protein network | https://string-db.org/network/9606.ENSP00000337746 | Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate [...] |
| PIDD1 protein network | https://string-db.org/network/9606.ENSP00000337797 | P53-induced death domain-containing protein 1; Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. As [...] |
| SPAG17 protein network | https://string-db.org/network/9606.ENSP00000337804 | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone [...] |
| MMP25 protein network | https://string-db.org/network/9606.ENSP00000337816 | Matrix metalloproteinase-25; May activate progelatinase A; M10 matrix metallopeptidases |
| LCK protein network | https://string-db.org/network/9606.ENSP00000337825 | Tyrosine-protein kinase Lck; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T- cells in the thymus and in the function of mature T [...] |
| RTN4 protein network | https://string-db.org/network/9606.ENSP00000337838 | Reticulon-4; Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasc [...] |
| KPTN protein network | https://string-db.org/network/9606.ENSP00000337850 | KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 [...] |
| ZNF576 protein network | https://string-db.org/network/9606.ENSP00000337852 | Zinc finger protein 576; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HEXDC protein network | https://string-db.org/network/9606.ENSP00000337854 | Hexosaminidase D; Has hexosaminidase activity; Belongs to the glycosyl hydrolase 20 family |
| OVOL1 protein network | https://string-db.org/network/9606.ENSP00000337862 | Putative transcription factor Ovo-like 1; Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital s [...] |
| MXD4 protein network | https://string-db.org/network/9606.ENSP00000337889 | Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC t [...] |
| MPP7 protein network | https://string-db.org/network/9606.ENSP00000337907 | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein c [...] |
| CYP3A4 protein network | https://string-db.org/network/9606.ENSP00000337915 | Cytochrome P450 3A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a var [...] |
| PACRG protein network | https://string-db.org/network/9606.ENSP00000337946 | Parkin coregulated gene protein; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pae [...] |
| HTR7 protein network | https://string-db.org/network/9606.ENSP00000337949 | 5-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...] |
| GDPD5 protein network | https://string-db.org/network/9606.ENSP00000337972 | Glycerophosphodiester phosphodiesterase domain-containing protein 5; Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester [...] |
| SUV39H1 protein network | https://string-db.org/network/9606.ENSP00000337976 | Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. Also weakly methylates h [...] |
| SPTY2D1 protein network | https://string-db.org/network/9606.ENSP00000337991 | Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding [...] |
| NCKAP5L protein network | https://string-db.org/network/9606.ENSP00000337998 | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylati [...] |
| IL21R protein network | https://string-db.org/network/9606.ENSP00000338010 | Interleukin-21 receptor; This is a receptor for interleukin-21; CD molecules |
| CCDC183 protein network | https://string-db.org/network/9606.ENSP00000338013 | Coiled-coil domain containing 183 |
| DNAJB2 protein network | https://string-db.org/network/9606.ENSP00000338019 | DnaJ homolog subfamily B member 2; Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In par [...] |
| STARD7 protein network | https://string-db.org/network/9606.ENSP00000338030 | StAR-related lipid transfer protein 7, mitochondrial; May play a protective role in mucosal tissues by preventing exaggerated allergic responses; StAR related lipid transfer domain containing |
| SPRYD4 protein network | https://string-db.org/network/9606.ENSP00000338034 | SPRY domain containing 4 |
| PSMF1 protein network | https://string-db.org/network/9606.ENSP00000338039 | Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the ac [...] |
| MRPL30 protein network | https://string-db.org/network/9606.ENSP00000338057 | Mitochondrial ribosomal protein L30 |
| TARSL2 protein network | https://string-db.org/network/9606.ENSP00000338093 | Probable threonine--tRNA ligase 2, cytoplasmic; threonyl-tRNA synthetase like 2; Belongs to the class-II aminoacyl-tRNA synthetase family |
| ZBTB16 protein network | https://string-db.org/network/9606.ENSP00000338157 | Zinc finger and BTB domain-containing protein 16; Probable transcription factor. May play a role in myeloid maturation and in the development and/or maintenance of other differentiated tissues. P [...] |
| TMEM217 protein network | https://string-db.org/network/9606.ENSP00000338164 | Transmembrane protein 217 |
| TMEM39B protein network | https://string-db.org/network/9606.ENSP00000338165 | Transmembrane protein 39B; Belongs to the TMEM39 family |
| SKAP1 protein network | https://string-db.org/network/9606.ENSP00000338171 | Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting [...] |
| PUM2 protein network | https://string-db.org/network/9606.ENSP00000338173 | Pumilio homolog 2; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Respo [...] |
| PLCB1 protein network | https://string-db.org/network/9606.ENSP00000338185 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...] |
| SNTB2 protein network | https://string-db.org/network/9606.ENSP00000338191 | Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and th [...] |
| LMO1 protein network | https://string-db.org/network/9606.ENSP00000338207 | Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors; LIM domain containing |
| ZNF532 protein network | https://string-db.org/network/9606.ENSP00000338217 | Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| C5orf56 protein network | https://string-db.org/network/9606.ENSP00000338228 | Uncharacterized protein C5orf56; Chromosome 5 open reading frame 56 |
| MTDH protein network | https://string-db.org/network/9606.ENSP00000338235 | Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor. Promotes anchorage-independent gro [...] |
| CDC42EP4 protein network | https://string-db.org/network/9606.ENSP00000338258 | Cdc42 effector protein 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pse [...] |
| APOL4 protein network | https://string-db.org/network/9606.ENSP00000338260 | Apolipoprotein L4; May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver (By similarity) |
| HEY1 protein network | https://string-db.org/network/9606.ENSP00000338272 | Hairy/enhancer-of-split related with YRPW motif protein 1; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalin [...] |
| CRISP1 protein network | https://string-db.org/network/9606.ENSP00000338276 | Cysteine-rich secretory protein 1; May have a role in sperm-egg fusion and maturation; Belongs to the CRISP family |
| NPAS2 protein network | https://string-db.org/network/9606.ENSP00000338283 | Neuronal PAS domain-containing protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various p [...] |
| GZF1 protein network | https://string-db.org/network/9606.ENSP00000338290 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression; Belongs to [...] |
| PAQR6 protein network | https://string-db.org/network/9606.ENSP00000338330 | Membrane progestin receptor delta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis [...] |
| SGCD protein network | https://string-db.org/network/9606.ENSP00000338343 | Delta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix |
| SNCA protein network | https://string-db.org/network/9606.ENSP00000338345 | Alpha-synuclein; May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apop [...] |
| UBE2G2 protein network | https://string-db.org/network/9606.ENSP00000338348 | Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved [...] |
| NUDT4 protein network | https://string-db.org/network/9606.ENSP00000338352 | Diphosphoinositol polyphosphate phosphohydrolase 2; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoi [...] |
| CELA3B protein network | https://string-db.org/network/9606.ENSP00000338369 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity |
| MRPL35 protein network | https://string-db.org/network/9606.ENSP00000338389 | Mitochondrial ribosomal protein L35 |
| UBA1 protein network | https://string-db.org/network/9606.ENSP00000338413 | Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiqui [...] |
| SUGCT protein network | https://string-db.org/network/9606.ENSP00000338475 | Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferr [...] |
| EPB41L2 protein network | https://string-db.org/network/9606.ENSP00000338481 | Band 4.1-like protein 2; Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase; Erythrocyte membrane protein band 4.1 |
| MGAT4B protein network | https://string-db.org/network/9606.ENSP00000338487 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- [...] |
| AGTPBP1 protein network | https://string-db.org/network/9606.ENSP00000338512 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...] |
| FNDC3B protein network | https://string-db.org/network/9606.ENSP00000338523 | Fibronectin type III domain-containing protein 3B; May be a positive regulator of adipogenesis; Fibronectin type III domain containing |
| FAM53B protein network | https://string-db.org/network/9606.ENSP00000338532 | Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization |
| TTC33 protein network | https://string-db.org/network/9606.ENSP00000338533 | Tetratricopeptide repeat domain containing |
| STX3 protein network | https://string-db.org/network/9606.ENSP00000338562 | Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family |
| ZNF212 protein network | https://string-db.org/network/9606.ENSP00000338572 | Zinc finger protein 212; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GNL3L protein network | https://string-db.org/network/9606.ENSP00000338573 | Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination an [...] |
| THEM6 protein network | https://string-db.org/network/9606.ENSP00000338607 | Protein THEM6; Thioesterase superfamily member 6 |
| CRYGN protein network | https://string-db.org/network/9606.ENSP00000338613 | Beta-gamma crystallins |
| TASP1 protein network | https://string-db.org/network/9606.ENSP00000338624 | Threonine aspartase 1; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster; Belongs to the Ntn-hydrolase family |
| SLC6A16 protein network | https://string-db.org/network/9606.ENSP00000338627 | Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5; Solute carrier family 6 member 16 |
| RERE protein network | https://string-db.org/network/9606.ENSP00000338629 | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits [...] |
| MUM1L1 protein network | https://string-db.org/network/9606.ENSP00000338641 | PWWP domain-containing protein MUM1L1; PWWP domain containing; Belongs to the MUM1 family |
| MS4A4A protein network | https://string-db.org/network/9606.ENSP00000338648 | Membrane-spanning 4-domains subfamily A member 4A; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| RHOBTB1 protein network | https://string-db.org/network/9606.ENSP00000338671 | Rho-related BTB domain-containing protein 1; Rho related BTB domain containing 1 |
| CDK10 protein network | https://string-db.org/network/9606.ENSP00000338673 | Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) |
| UGP2 protein network | https://string-db.org/network/9606.ENSP00000338703 | UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family |
| LRRFIP2 protein network | https://string-db.org/network/9606.ENSP00000338727 | Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta- catenin. Positively regu [...] |
| CCDC88A protein network | https://string-db.org/network/9606.ENSP00000338728 | Girdin; Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron p [...] |
| NPHP3 protein network | https://string-db.org/network/9606.ENSP00000338766 | Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt s [...] |
| ASAP3 protein network | https://string-db.org/network/9606.ENSP00000338769 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; Promotes cell proliferation; Ankyrin repeat domain containing |
| ZNF420 protein network | https://string-db.org/network/9606.ENSP00000338770 | Zinc finger protein 420; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| BCL11A protein network | https://string-db.org/network/9606.ENSP00000338774 | B-cell lymphoma/leukemia 11A; Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. Involved in brain devel [...] |
| AP3S2 protein network | https://string-db.org/network/9606.ENSP00000338777 | AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...] |
| CHST5 protein network | https://string-db.org/network/9606.ENSP00000338783 | Carbohydrate sulfotransferase 5; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...] |
| STARD13 protein network | https://string-db.org/network/9606.ENSP00000338785 | StAR-related lipid transfer protein 13; GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motili [...] |
| ZC3H15 protein network | https://string-db.org/network/9606.ENSP00000338788 | Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation; Zinc fingers CCCH-type |
| SSX2 protein network | https://string-db.org/network/9606.ENSP00000338796 | Synovial sarcoma, X breakpoint 2; SSX family member 2 |
| ZBTB49 protein network | https://string-db.org/network/9606.ENSP00000338807 | Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription; Belongs to the krueppel C2H [...] |
| C1QTNF6 protein network | https://string-db.org/network/9606.ENSP00000338812 | Complement C1q tumor necrosis factor-related protein 6; C1q and TNF related 6 |
| BAG5 protein network | https://string-db.org/network/9606.ENSP00000338814 | BAG family molecular chaperone regulator 5; Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). May function as a nucleotide exchange factor f [...] |
| SEC23B protein network | https://string-db.org/network/9606.ENSP00000338844 | Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| ZNF444 protein network | https://string-db.org/network/9606.ENSP00000338860 | Zinc finger protein 444; Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter; Belongs to the krueppel C2H2-type zinc-finger protein family |
| BRIX1 protein network | https://string-db.org/network/9606.ENSP00000338862 | Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit |
| RASGRP2 protein network | https://string-db.org/network/9606.ENSP00000338864 | RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates othe [...] |
| C2CD2L protein network | https://string-db.org/network/9606.ENSP00000338885 | Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5- bisphosphate (PI(4,5)P2), from its site of synthesis i [...] |
| LRRC8D protein network | https://string-db.org/network/9606.ENSP00000338887 | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...] |
| ZNF385A protein network | https://string-db.org/network/9606.ENSP00000338927 | Zinc finger protein 385A; RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA an [...] |
| GGT7 protein network | https://string-db.org/network/9606.ENSP00000338964 | Glutathione hydrolase 7; Cleaves glutathione conjugates; Gamma-glutamyltransferases |
| ARHGAP6 protein network | https://string-db.org/network/9606.ENSP00000338967 | Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin [...] |
| ATG101 protein network | https://string-db.org/network/9606.ENSP00000338990 | Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation; Belongs to the ATG101 family |
| TUBB protein network | https://string-db.org/network/9606.ENSP00000339001 | Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chai [...] |
| FOXG1 protein network | https://string-db.org/network/9606.ENSP00000339004 | Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telen [...] |
| ATAD1 protein network | https://string-db.org/network/9606.ENSP00000339017 | ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learnin [...] |
| ZFP91 protein network | https://string-db.org/network/9606.ENSP00000339030 | E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby act [...] |
| EEF1A1 protein network | https://string-db.org/network/9606.ENSP00000339063 | Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that act [...] |
| FGFBP3 protein network | https://string-db.org/network/9606.ENSP00000339067 | Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix g [...] |
| MKL2 protein network | https://string-db.org/network/9606.ENSP00000339086 | MKL/myocardin-like protein 2; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation; Myocardin family |
| RBMX2 protein network | https://string-db.org/network/9606.ENSP00000339090 | RNA binding motif protein, X-linked 2 |
| RPS7 protein network | https://string-db.org/network/9606.ENSP00000339095 | 40S ribosomal protein S7; Required for rRNA maturation; Belongs to the eukaryotic ribosomal protein eS7 family |
| ANAPC1 protein network | https://string-db.org/network/9606.ENSP00000339109 | Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...] |
| ESPNL protein network | https://string-db.org/network/9606.ENSP00000339115 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing; An [...] |
| ERAS protein network | https://string-db.org/network/9606.ENSP00000339136 | GTPase ERas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells (By similarity); Belongs to the s [...] |
| RRP1B protein network | https://string-db.org/network/9606.ENSP00000339145 | Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional acti [...] |
| CRISP2 protein network | https://string-db.org/network/9606.ENSP00000339155 | Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation; Cysteine rich secretory protein family |
| AIDA protein network | https://string-db.org/network/9606.ENSP00000339161 | Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. [...] |
| TSSK4 protein network | https://string-db.org/network/9606.ENSP00000339179 | Testis-specific serine/threonine-protein kinase 4; May be involved in a signaling pathway during male germ cell development or mature sperm function (By similarity). Phosphorylates CREB1 on Ser-1 [...] |
| ATP13A4 protein network | https://string-db.org/network/9606.ENSP00000339182 | Probable cation-transporting ATPase 13A4; ATPase orphan transporters; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily |
| GRAP2 protein network | https://string-db.org/network/9606.ENSP00000339186 | GRB2-related adapter protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; SH2 domain containing |
| CAV1 protein network | https://string-db.org/network/9606.ENSP00000339191 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in [...] |
| DPP8 protein network | https://string-db.org/network/9606.ENSP00000339208 | Dipeptidyl peptidase 8; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune functi [...] |
| KRTAP24-1 protein network | https://string-db.org/network/9606.ENSP00000339238 | Keratin-associated protein 24-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| YTHDC1 protein network | https://string-db.org/network/9606.ENSP00000339245 | YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs. M6A is a modification present at internal sites [...] |
| DPPA3 protein network | https://string-db.org/network/9606.ENSP00000339250 | Developmental pluripotency-associated protein 3; Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA [...] |
| KRTDAP protein network | https://string-db.org/network/9606.ENSP00000339251 | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis |
| NIPAL2 protein network | https://string-db.org/network/9606.ENSP00000339256 | NIPA-like protein 2; NIPA like domain containing 2; Belongs to the NIPA family |
| SLC6A13 protein network | https://string-db.org/network/9606.ENSP00000339260 | Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be i [...] |
| CCDC30 protein network | https://string-db.org/network/9606.ENSP00000339280 | Coiled-coil domain containing 30; Belongs to the prefoldin subunit beta family |
| TRIO protein network | https://string-db.org/network/9606.ENSP00000339299 | Triple functional domain protein; Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. [...] |
| ZNF70 protein network | https://string-db.org/network/9606.ENSP00000339314 | Zinc finger protein 70; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SMIM15 protein network | https://string-db.org/network/9606.ENSP00000339324 | Small integral membrane protein 15 |
| PLAUR protein network | https://string-db.org/network/9606.ENSP00000339328 | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-inde [...] |
| KCTD21 protein network | https://string-db.org/network/9606.ENSP00000339340 | BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal [...] |
| KLRG2 protein network | https://string-db.org/network/9606.ENSP00000339356 | Killer cell lectin like receptor G2; C-type lectin domain containing |
| LGALS12 protein network | https://string-db.org/network/9606.ENSP00000339374 | Galectin-12; Binds lactose. May participate in the apoptosis of adipocytes; Galectins |
| RGS12 protein network | https://string-db.org/network/9606.ENSP00000339381 | Regulator of G-protein signaling 12; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...] |
| C2orf66 protein network | https://string-db.org/network/9606.ENSP00000339384 | Uncharacterized protein C2orf66; Chromosome 2 open reading frame 66 |
| OTUD6A protein network | https://string-db.org/network/9606.ENSP00000339389 | OTU domain-containing protein 6A; Deubiquitinating enzyme that hydrolyzes 'Lys-27'-, 'Lys- 29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains; [...] |
| CDH26 protein network | https://string-db.org/network/9606.ENSP00000339390 | Cadherin-like protein 26; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contr [...] |
| HLA-DQA1 protein network | https://string-db.org/network/9606.ENSP00000339398 | Major histocompatibility complex, class II, DQ alpha 1; Belongs to the MHC class II family |
| ASCC1 protein network | https://string-db.org/network/9606.ENSP00000339404 | Activating signal cointegrator 1 complex subunit 1; Enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction o [...] |
| TP53TG3B protein network | https://string-db.org/network/9606.ENSP00000339405 | TP53 target 3B; May play a significant role in p53/TP53-mediating signaling pathway |
| SRR protein network | https://string-db.org/network/9606.ENSP00000339435 | Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D- serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine |
| WDR16 protein network | https://string-db.org/network/9606.ENSP00000339449 | Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival |
| RHOG protein network | https://string-db.org/network/9606.ENSP00000339467 | Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structur [...] |
| B7RP1 protein network | https://string-db.org/network/9606.ENSP00000339477 | Inducible T-cell co-stimulator ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-ce [...] |
| NT5C2 protein network | https://string-db.org/network/9606.ENSP00000339479 | Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Pre [...] |
| ZFAND4 protein network | https://string-db.org/network/9606.ENSP00000339484 | Zinc finger AN1-type containing 4 |
| NELFB protein network | https://string-db.org/network/9606.ENSP00000339495 | Negative elongation factor B; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...] |
| HYPM protein network | https://string-db.org/network/9606.ENSP00000339511 | Huntingtin interacting protein M |
| DFFB protein network | https://string-db.org/network/9606.ENSP00000339524 | DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology |
| THUMPD3 protein network | https://string-db.org/network/9606.ENSP00000339532 | THUMP domain-containing protein 3; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily |
| HIST1H1C protein network | https://string-db.org/network/9606.ENSP00000339566 | Histone H1.2; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucle [...] |
| RHD protein network | https://string-db.org/network/9606.ENSP00000339577 | Rh blood group D antigen; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily |
| ZNF449 protein network | https://string-db.org/network/9606.ENSP00000339585 | Zinc finger protein 449; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| DFNA5 protein network | https://string-db.org/network/9606.ENSP00000339587 | Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53 |
| POFUT2 protein network | https://string-db.org/network/9606.ENSP00000339613 | GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2, [...] |
| LCN6 protein network | https://string-db.org/network/9606.ENSP00000339621 | Epididymal-specific lipocalin-6; May play a role in male fertility; Lipocalins |
| SLC35E4 protein network | https://string-db.org/network/9606.ENSP00000339626 | Solute carrier family 35 member E4; Putative transporter; Solute carriers |
| KIR2DL4 protein network | https://string-db.org/network/9606.ENSP00000339634 | Killer cell immunoglobulin-like receptor 2DL4; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules |
| BRAT1 protein network | https://string-db.org/network/9606.ENSP00000339637 | BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Play [...] |
| TRIM2 protein network | https://string-db.org/network/9606.ENSP00000339659 | Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May p [...] |
| FAM78B protein network | https://string-db.org/network/9606.ENSP00000339681 | Protein FAM78B; Family with sequence similarity 78 member B; Belongs to the FAM78 family |
| RASSF4 protein network | https://string-db.org/network/9606.ENSP00000339692 | Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest; Ras association domain family |
| NDUFA4 protein network | https://string-db.org/network/9606.ENSP00000339720 | Cytochrome c oxidase subunit NDUFA4; Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Requi [...] |
| CIR1 protein network | https://string-db.org/network/9606.ENSP00000339723 | Corepressor interacting with RBPJ 1; May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruit [...] |
| OR14I1 protein network | https://string-db.org/network/9606.ENSP00000339726 | Olfactory receptor 14I1; Odorant receptor; Olfactory receptors, family 14 |
| THBS4 protein network | https://string-db.org/network/9606.ENSP00000339730 | Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and a [...] |
| CAMK2D protein network | https://string-db.org/network/9606.ENSP00000339740 | Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling [...] |
| ARL4C protein network | https://string-db.org/network/9606.ENSP00000339754 | ADP-ribosylation factor-like protein 4C; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...] |
| PRDM8 protein network | https://string-db.org/network/9606.ENSP00000339764 | PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcripti [...] |
| ZNF433 protein network | https://string-db.org/network/9606.ENSP00000339767 | Zinc finger protein 433; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ACSL4 protein network | https://string-db.org/network/9606.ENSP00000339787 | Long-chain-fatty-acid--CoA ligase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapen [...] |
| RPL7 protein network | https://string-db.org/network/9606.ENSP00000339795 | 60S ribosomal protein L7; Component of the large ribosomal subunit. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free t [...] |
| IDS protein network | https://string-db.org/network/9606.ENSP00000339801 | Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases |
| ANKRD34B protein network | https://string-db.org/network/9606.ENSP00000339802 | Ankyrin repeat domain-containing protein 34B; Ankyrin repeat domain containing; Belongs to the ANKRD34 family |
| TSLP protein network | https://string-db.org/network/9606.ENSP00000339804 | Thymic stromal lymphopoietin; Isoform 1: Cytokine that induces the release of T-cell- attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. [...] |
| TPST2 protein network | https://string-db.org/network/9606.ENSP00000339813 | Protein-tyrosine sulfotransferase 2; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Sulfotransferases [...] |
| TSPAN18 protein network | https://string-db.org/network/9606.ENSP00000339820 | Tetraspanin-18; Tetraspanin 18; Tetraspanins |
| ZNF546 protein network | https://string-db.org/network/9606.ENSP00000339823 | Zinc finger protein 546; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FGFR3 protein network | https://string-db.org/network/9606.ENSP00000339824 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, [...] |
| PIK3AP1 protein network | https://string-db.org/network/9606.ENSP00000339826 | Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signal [...] |
| TMEM220 protein network | https://string-db.org/network/9606.ENSP00000339830 | Transmembrane protein 220 |
| SNRNP48 protein network | https://string-db.org/network/9606.ENSP00000339834 | U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5' splice site recognition; U11/U12 di-snRNP |
| H3F3C protein network | https://string-db.org/network/9606.ENSP00000339835 | Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...] |
| MRPL43 protein network | https://string-db.org/network/9606.ENSP00000339844 | Mitochondrial ribosomal protein L43 |
| DPYSL4 protein network | https://string-db.org/network/9606.ENSP00000339850 | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse a [...] |
| CLCN1 protein network | https://string-db.org/network/9606.ENSP00000339867 | Chloride channel protein 1; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction [...] |
| MIOS protein network | https://string-db.org/network/9606.ENSP00000339881 | GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 [...] |
| LBR protein network | https://string-db.org/network/9606.ENSP00000339883 | Lamin-B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane; Tudor domain containing |
| PAX4 protein network | https://string-db.org/network/9606.ENSP00000339906 | Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, [...] |
| LIMK2 protein network | https://string-db.org/network/9606.ENSP00000339916 | LIM domain kinase 2; Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro; LIM domain containing |
| TAF9B protein network | https://string-db.org/network/9606.ENSP00000339917 | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of [...] |
| XRRA1 protein network | https://string-db.org/network/9606.ENSP00000339918 | X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation |
| PKLR protein network | https://string-db.org/network/9606.ENSP00000339933 | Pyruvate kinase PKLR; Plays a key role in glycolysis; Belongs to the pyruvate kinase family |
| NISCH protein network | https://string-db.org/network/9606.ENSP00000339958 | Nischarin; Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiati [...] |
| MROH8 protein network | https://string-db.org/network/9606.ENSP00000339971 | Protein MROH8; Maestro heat like repeat family member 8 |
| TBC1D28 protein network | https://string-db.org/network/9606.ENSP00000339973 | TBC1 domain family member 28 |
| TAF1A protein network | https://string-db.org/network/9606.ENSP00000339976 | TATA box-binding protein-associated factor RNA polymerase I subunit A; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation comp [...] |
| MYB protein network | https://string-db.org/network/9606.ENSP00000339992 | Transcriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and [...] |
| ZNF564 protein network | https://string-db.org/network/9606.ENSP00000340004 | Zinc finger protein 564; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DOC2A protein network | https://string-db.org/network/9606.ENSP00000340017 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium depende [...] |
| KRCC1 protein network | https://string-db.org/network/9606.ENSP00000340083 | Lysine rich coiled-coil 1 |
| THEG protein network | https://string-db.org/network/9606.ENSP00000340088 | Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis |
| PPP1R17 protein network | https://string-db.org/network/9606.ENSP00000340125 | Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes |
| ZNF383 protein network | https://string-db.org/network/9606.ENSP00000340132 | Zinc finger protein 383; May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways; Zinc fingers C2H2-type |
| RBPMS protein network | https://string-db.org/network/9606.ENSP00000340176 | RNA-binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to inc [...] |
| TMEM202 protein network | https://string-db.org/network/9606.ENSP00000340212 | Transmembrane protein 202 |
| C7orf26 protein network | https://string-db.org/network/9606.ENSP00000340220 | Uncharacterized protein C7orf26; Chromosome 7 open reading frame 26 |
| LMX1A protein network | https://string-db.org/network/9606.ENSP00000340226 | LIM homeobox transcription factor 1-alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the [...] |
| SERINC3 protein network | https://string-db.org/network/9606.ENSP00000340243 | Serine incorporator 3; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the vira [...] |
| TAF3 protein network | https://string-db.org/network/9606.ENSP00000340271 | Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeri [...] |
| RAP2C protein network | https://string-db.org/network/9606.ENSP00000340274 | Ras-related protein Rap-2c; Small GTP-binding protein which cycles between a GDP- bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spre [...] |
| SSX2IP protein network | https://string-db.org/network/9606.ENSP00000340279 | Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Ma [...] |
| DLK1 protein network | https://string-db.org/network/9606.ENSP00000340292 | Protein delta homolog 1; May have a role in neuroendocrine differentiation |
| ACSM6 protein network | https://string-db.org/network/9606.ENSP00000340296 | Acyl-coenzyme A synthetase ACSM6, mitochondrial; acyl-CoA synthetase medium chain family member 6 |
| ARHGEF10 protein network | https://string-db.org/network/9606.ENSP00000340297 | Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves; Rho guanine nucleotide exchange factors |
| ZDHHC1 protein network | https://string-db.org/network/9606.ENSP00000340299 | Probable palmitoyltransferase ZDHHC1; Zinc finger DHHC-type containing 1; Belongs to the DHHC palmitoyltransferase family |
| UBE2V1 protein network | https://string-db.org/network/9606.ENSP00000340305 | Ubiquitin-conjugating enzyme E2 variant 1; Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are link [...] |
| NYX protein network | https://string-db.org/network/9606.ENSP00000340328 | Nyctalopin |
| CAPRIN1 protein network | https://string-db.org/network/9606.ENSP00000340329 | Caprin-1; May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly an [...] |
| KAT5 protein network | https://string-db.org/network/9606.ENSP00000340330 | Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] |
| TCF7 protein network | https://string-db.org/network/9606.ENSP00000340347 | Transcription factor 7; Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal C [...] |
| ACVR2B protein network | https://string-db.org/network/9606.ENSP00000340361 | Activin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or [...] |
| SLC15A5 protein network | https://string-db.org/network/9606.ENSP00000340402 | Solute carrier family 15 member 5; Proton oligopeptide cotransporter; Solute carriers |
| SMPD1 protein network | https://string-db.org/network/9606.ENSP00000340409 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol |
| ERMP1 protein network | https://string-db.org/network/9606.ENSP00000340427 | Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures |
| LDOC1L protein network | https://string-db.org/network/9606.ENSP00000340434 | Retrotransposon Gag-like protein 6; Leucine zipper, down-regulated in cancer 1-like |
| FAM154B protein network | https://string-db.org/network/9606.ENSP00000340445 | Stabilizer of axonemal microtubules 2; Family with sequence similarity 154, member B |
| RAP1GDS1 protein network | https://string-db.org/network/9606.ENSP00000340454 | Rap1 GTPase-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating th [...] |
| SLC20A2 protein network | https://string-db.org/network/9606.ENSP00000340465 | Sodium-dependent phosphate transporter 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for [...] |
| GANAB protein network | https://string-db.org/network/9606.ENSP00000340466 | Neutral alpha-glucosidase AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required f [...] |
| LRRC16B protein network | https://string-db.org/network/9606.ENSP00000340467 | Capping protein, Arp2/3 and myosin-I linker protein 3; Leucine rich repeat containing 16B; Belongs to the CARMIL family |
| EXD3 protein network | https://string-db.org/network/9606.ENSP00000340474 | Exonuclease mut-7 homolog; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity) |
| ZNF395 protein network | https://string-db.org/network/9606.ENSP00000340494 | Zinc finger protein 395; Plays a role in papillomavirus genes transcription; Zinc fingers C2H2-type |
| SENP8 protein network | https://string-db.org/network/9606.ENSP00000340505 | Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted prot [...] |
| TRIM24 protein network | https://string-db.org/network/9606.ENSP00000340507 | Transcription intermediary factor 1-alpha; Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts w [...] |
| PPL protein network | https://string-db.org/network/9606.ENSP00000340510 | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated si [...] |
| ZNF14 protein network | https://string-db.org/network/9606.ENSP00000340514 | Zinc finger protein 14; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LRRC37B protein network | https://string-db.org/network/9606.ENSP00000340519 | Leucine-rich repeat-containing protein 37B; Leucine rich repeat containing 37B |
| NMNAT3 protein network | https://string-db.org/network/9606.ENSP00000340523 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic aci [...] |
| UTS2B protein network | https://string-db.org/network/9606.ENSP00000340526 | Urotensin-2B; Potent vasoconstrictor; Endogenous ligands |
| KRTAP4-5 protein network | https://string-db.org/network/9606.ENSP00000340546 | Keratin-associated protein 4-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| COX8C protein network | https://string-db.org/network/9606.ENSP00000340568 | Cytochrome c oxidase subunit 8C, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| RASSF6 protein network | https://string-db.org/network/9606.ENSP00000340578 | Ras association domain-containing protein 6; Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppre [...] |
| ZCCHC16 protein network | https://string-db.org/network/9606.ENSP00000340590 | Retrotransposon Gag-like protein 4; Involved in cognitive function in the brain, possibly via the noradrenergic system |
| SYDE2 protein network | https://string-db.org/network/9606.ENSP00000340594 | Rho GTPase-activating protein SYDE2; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; C2 domain containing |
| UBE3B protein network | https://string-db.org/network/9606.ENSP00000340596 | Ubiquitin-protein ligase E3B; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to t [...] |
| SGK2 protein network | https://string-db.org/network/9606.ENSP00000340608 | Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proli [...] |
| DUPD1 protein network | https://string-db.org/network/9606.ENSP00000340609 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a s [...] |
| POTEH protein network | https://string-db.org/network/9606.ENSP00000340610 | POTE ankyrin domain family member H |
| C15orf43 protein network | https://string-db.org/network/9606.ENSP00000340644 | Telomere repeats-binding bouquet formation protein 2; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homolo [...] |
| HUWE1 protein network | https://string-db.org/network/9606.ENSP00000340648 | E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyu [...] |
| ELSPBP1 protein network | https://string-db.org/network/9606.ENSP00000340660 | Epididymal sperm-binding protein 1; Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity); Belongs to the seminal [...] |
| TMEM248 protein network | https://string-db.org/network/9606.ENSP00000340668 | Transmembrane protein 248 |
| ARMCX3 protein network | https://string-db.org/network/9606.ENSP00000340672 | Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the TRAK2- kinesin motor complex via its int [...] |
| WNT8B protein network | https://string-db.org/network/9606.ENSP00000340677 | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, nota [...] |
| ZNF823 protein network | https://string-db.org/network/9606.ENSP00000340683 | Zinc finger protein 823; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MAOA protein network | https://string-db.org/network/9606.ENSP00000340684 | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in th [...] |
| LPHN1 protein network | https://string-db.org/network/9606.ENSP00000340688 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive ex [...] |
| EIF4EBP1 protein network | https://string-db.org/network/9606.ENSP00000340691 | Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphoryla [...] |
| GYG1 protein network | https://string-db.org/network/9606.ENSP00000340736 | Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase; Glycosyltransferase family 8 |
| OR13H1 protein network | https://string-db.org/network/9606.ENSP00000340748 | Olfactory receptor 13H1; Odorant receptor; Olfactory receptors, family 13 |
| BRI3BP protein network | https://string-db.org/network/9606.ENSP00000340761 | BRI3-binding protein; Involved in tumorigenesis and may function by stabilizing p53/TP53 |
| CCDC108 protein network | https://string-db.org/network/9606.ENSP00000340776 | Cilia- and flagella-associated protein 65; May play a role in sperm motility; Belongs to the CFAP65 family |
| ZNF326 protein network | https://string-db.org/network/9606.ENSP00000340796 | DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates tran [...] |
| GJB5 protein network | https://string-db.org/network/9606.ENSP00000340811 | Gap junction beta-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| MAPT protein network | https://string-db.org/network/9606.ENSP00000340820 | Microtubule-associated protein tau; Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal micro [...] |
| GTF2F2 protein network | https://string-db.org/network/9606.ENSP00000340823 | General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration w [...] |
| OSTF1 protein network | https://string-db.org/network/9606.ENSP00000340836 | Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity; Anky [...] |
| ZC3H12B protein network | https://string-db.org/network/9606.ENSP00000340839 | Probable ribonuclease ZC3H12B; May function as RNase and regulate the levels of target RNA species; Zinc fingers CCCH-type |
| ZNF621 protein network | https://string-db.org/network/9606.ENSP00000340841 | Zinc finger protein 621; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| C1QTNF1 protein network | https://string-db.org/network/9606.ENSP00000340864 | Complement C1q tumor necrosis factor-related protein 1; C1q and TNF related 1 |
| MEF2C protein network | https://string-db.org/network/9606.ENSP00000340874 | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morpho [...] |
| C5orf47 protein network | https://string-db.org/network/9606.ENSP00000340887 | Uncharacterized protein C5orf47; Chromosome 5 open reading frame 47 |
| ASH2L protein network | https://string-db.org/network/9606.ENSP00000340896 | Set1/Ash2 histone methyltransferase complex subunit ASH2; Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not [...] |
| MIA3 protein network | https://string-db.org/network/9606.ENSP00000340900 | Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated [...] |
| TRPC6 protein network | https://string-db.org/network/9606.ENSP00000340913 | Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...] |
| SYT3 protein network | https://string-db.org/network/9606.ENSP00000340914 | Synaptotagmin-3; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to [...] |
| DMP1 protein network | https://string-db.org/network/9606.ENSP00000340935 | Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional [...] |
| COL17A1 protein network | https://string-db.org/network/9606.ENSP00000340937 | Collagen alpha-1(XVII) chain; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane; Collagens |
| CRHR2 protein network | https://string-db.org/network/9606.ENSP00000340943 | Corticotropin-releasing factor receptor 2; G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a [...] |
| PTPN11 protein network | https://string-db.org/network/9606.ENSP00000340944 | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to [...] |
| CNBD2 protein network | https://string-db.org/network/9606.ENSP00000340954 | Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the [...] |
| SOWAHD protein network | https://string-db.org/network/9606.ENSP00000340975 | Ankyrin repeat domain-containing protein SOWAHD; Sosondowah ankyrin repeat domain family member D; Belongs to the SOWAH family |
| RNF175 protein network | https://string-db.org/network/9606.ENSP00000340979 | Ring finger protein 175 |
| SPAG8 protein network | https://string-db.org/network/9606.ENSP00000340982 | Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CR [...] |
| LRRC25 protein network | https://string-db.org/network/9606.ENSP00000340983 | Leucine-rich repeat-containing protein 25; May be involved in the activation of cells of innate and acquired immunity |
| LDLRAD2 protein network | https://string-db.org/network/9606.ENSP00000340988 | Low density lipoprotein receptor class A domain containing 2 |
| SFN protein network | https://string-db.org/network/9606.ENSP00000340989 | 14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognit [...] |
| NTN4 protein network | https://string-db.org/network/9606.ENSP00000340998 | Netrin-4; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants; Netrins |
| AMTN protein network | https://string-db.org/network/9606.ENSP00000341013 | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of a [...] |
| NANOS2 protein network | https://string-db.org/network/9606.ENSP00000341021 | Nanos homolog 2; Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis [...] |
| CSN2 protein network | https://string-db.org/network/9606.ENSP00000341030 | Beta-casein; Important role in determination of the surface properties of the casein micelles; Belongs to the beta-casein family |
| TPRG1 protein network | https://string-db.org/network/9606.ENSP00000341031 | Tumor protein p63 regulated 1; Belongs to the TPRG1 family |
| WNT7B protein network | https://string-db.org/network/9606.ENSP00000341032 | Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| ACACB protein network | https://string-db.org/network/9606.ENSP00000341044 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltran [...] |
| UGT2B15 protein network | https://string-db.org/network/9606.ENSP00000341045 | UDP-glucuronosyltransferase 2B15; UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays act [...] |
| CLEC18B protein network | https://string-db.org/network/9606.ENSP00000341051 | C-type lectin domain family 18 member B; Binds polysaccharides in a Ca(2+)-independent manner (By similarity); C-type lectin domain containing |
| ARHGEF3 protein network | https://string-db.org/network/9606.ENSP00000341071 | Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases |
| MRPL20 protein network | https://string-db.org/network/9606.ENSP00000341082 | Mitochondrial ribosomal protein L20 |
| NPR2 protein network | https://string-db.org/network/9606.ENSP00000341083 | Atrial natriuretic peptide receptor 2; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation o [...] |
| HIST1H2AD protein network | https://string-db.org/network/9606.ENSP00000341094 | Histone H2A type 1-D; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| HMX2 protein network | https://string-db.org/network/9606.ENSP00000341108 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development; NKL subclass homeoboxes and pseudoge [...] |
| C3orf62 protein network | https://string-db.org/network/9606.ENSP00000341139 | Uncharacterized protein C3orf62; Chromosome 3 open reading frame 62 |
| SIGLEC1 protein network | https://string-db.org/network/9606.ENSP00000341141 | Sialoadhesin; Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including [...] |
| CERKL protein network | https://string-db.org/network/9606.ENSP00000341159 | Ceramide kinase-like protein; Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions |
| ZNF772 protein network | https://string-db.org/network/9606.ENSP00000341165 | Zinc finger protein 772; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PTN protein network | https://string-db.org/network/9606.ENSP00000341170 | Pleiotrophin; Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces [...] |
| MTSS1L protein network | https://string-db.org/network/9606.ENSP00000341171 | MTSS1-like protein; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in act [...] |
| C15orf62 protein network | https://string-db.org/network/9606.ENSP00000341178 | Uncharacterized protein C15orf62, mitochondrial; Chromosome 15 open reading frame 62 |
| PTK2 protein network | https://string-db.org/network/9606.ENSP00000341189 | Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation a [...] |
| NEO1 protein network | https://string-db.org/network/9606.ENSP00000341198 | Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. [...] |
| CHST4 protein network | https://string-db.org/network/9606.ENSP00000341206 | Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetyl [...] |
| STAT5A protein network | https://string-db.org/network/9606.ENSP00000341208 | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and ot [...] |
| C20orf24 protein network | https://string-db.org/network/9606.ENSP00000341213 | Uncharacterized protein C20orf24; Chromosome 20 open reading frame 24 |
| HIST1H1T protein network | https://string-db.org/network/9606.ENSP00000341214 | Histone H1t; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin archite [...] |
| CECR2 protein network | https://string-db.org/network/9606.ENSP00000341219 | Cat eye syndrome critical region protein 2; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex. It ther [...] |
| ZNF695 protein network | https://string-db.org/network/9606.ENSP00000341236 | Zinc finger protein 695; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RBPJL protein network | https://string-db.org/network/9606.ENSP00000341243 | Recombining binding protein suppressor of hairless-like protein; Putative transcription factor, which cooperates with EBNA2 to activate transcription; Belongs to the Su(H) family |
| GSPT2 protein network | https://string-db.org/network/9606.ENSP00000341247 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulat [...] |
| TRADD protein network | https://string-db.org/network/9606.ENSP00000341268 | Tumor necrosis factor receptor type 1-associated DEATH domain protein; The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by [...] |
| JARID2 protein network | https://string-db.org/network/9606.ENSP00000341280 | Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hema [...] |
| SYCE1 protein network | https://string-db.org/network/9606.ENSP00000341282 | Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...] |
| TUBB4B protein network | https://string-db.org/network/9606.ENSP00000341289 | Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...] |
| OR2G6 protein network | https://string-db.org/network/9606.ENSP00000341291 | Olfactory receptor 2G6; Odorant receptor; Olfactory receptors, family 2 |
| WNK1 protein network | https://string-db.org/network/9606.ENSP00000341292 | Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an a [...] |
| SRFBP1 protein network | https://string-db.org/network/9606.ENSP00000341324 | Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of S [...] |
| KLHL6 protein network | https://string-db.org/network/9606.ENSP00000341342 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation; BTB domain containing |
| GGA1 protein network | https://string-db.org/network/9606.ENSP00000341344 | ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clath [...] |
| TEKT1 protein network | https://string-db.org/network/9606.ENSP00000341346 | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules; Belongs to the tektin family |
| DCAF5 protein network | https://string-db.org/network/9606.ENSP00000341351 | DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| COBLL1 protein network | https://string-db.org/network/9606.ENSP00000341360 | Cordon-bleu WH2 repeat protein like 1 |
| RNF13 protein network | https://string-db.org/network/9606.ENSP00000341361 | E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation; Ring finger proteins |
| TMEM230 protein network | https://string-db.org/network/9606.ENSP00000341364 | Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles; Belongs to the TMEM134/TMEM230 family |
| C6orf132 protein network | https://string-db.org/network/9606.ENSP00000341368 | Uncharacterized protein C6orf132; Chromosome 6 open reading frame 132 |
| PLET1 protein network | https://string-db.org/network/9606.ENSP00000341412 | Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a ro [...] |
| P4HTM protein network | https://string-db.org/network/9606.ENSP00000341422 | Transmembrane prolyl 4-hydroxylase; Catalyzes the post-translational formation of 4- hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564' [...] |
| SNTN protein network | https://string-db.org/network/9606.ENSP00000341442 | Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules |
| RANBP3 protein network | https://string-db.org/network/9606.ENSP00000341483 | Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In [...] |
| SYDE1 protein network | https://string-db.org/network/9606.ENSP00000341489 | Rho GTPase-activating protein SYDE1; GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells m [...] |
| ISM2 protein network | https://string-db.org/network/9606.ENSP00000341490 | Isthmin-2; Isthmin 2 |
| SEPT6 protein network | https://string-db.org/network/9606.ENSP00000341524 | Septin-6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous st [...] |
| ZNF34 protein network | https://string-db.org/network/9606.ENSP00000341528 | Zinc finger protein 34; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TCAIM protein network | https://string-db.org/network/9606.ENSP00000341539 | T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis |
| KLHL33 protein network | https://string-db.org/network/9606.ENSP00000341549 | Kelch-like protein 33; Kelch like family member 33 |
| SLC24A5 protein network | https://string-db.org/network/9606.ENSP00000341550 | Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. P [...] |
| SMAD4 protein network | https://string-db.org/network/9606.ENSP00000341551 | Mothers against decapentaplegic homolog 4; In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phospho [...] |
| B4GALNT1 protein network | https://string-db.org/network/9606.ENSP00000341562 | Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Beta 4-glycosyltransferases |
| PAQR9 protein network | https://string-db.org/network/9606.ENSP00000341564 | Membrane progestin receptor epsilon; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signali [...] |
| FAM111B protein network | https://string-db.org/network/9606.ENSP00000341565 | Protein FAM111B; Family with sequence similarity 111 member B; Belongs to the FAM111 family |
| OR52B6 protein network | https://string-db.org/network/9606.ENSP00000341581 | Olfactory receptor 52B6; Odorant receptor; Olfactory receptors, family 52 |
| SERPINB13 protein network | https://string-db.org/network/9606.ENSP00000341584 | Serpin B13; May play a role in the proliferation or differentiation of keratinocytes; Belongs to the serpin family. Ov-serpin subfamily |
| FAM114A2 protein network | https://string-db.org/network/9606.ENSP00000341597 | Protein FAM114A2; Family with sequence similarity 114 member A2; Belongs to the FAM114 family |
| C15orf48 protein network | https://string-db.org/network/9606.ENSP00000341610 | Normal mucosa of esophagus-specific gene 1 protein; Chromosome 15 open reading frame 48; Belongs to the complex I NDUFA4 subunit family |
| CYB5A protein network | https://string-db.org/network/9606.ENSP00000341625 | Cytochrome b5; Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases |
| NCR3LG1 protein network | https://string-db.org/network/9606.ENSP00000341637 | Natural cytotoxicity triggering receptor 3 ligand 1; Triggers NCR3-dependent natural killer cell activation; C1-set domain containing |
| COL9A3 protein network | https://string-db.org/network/9606.ENSP00000341640 | Collagen alpha-3(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans |
| THYN1 protein network | https://string-db.org/network/9606.ENSP00000341657 | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC |
| DUSP15 protein network | https://string-db.org/network/9606.ENSP00000341658 | Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6; Atypical dual specificity phosphatases |
| AGMO protein network | https://string-db.org/network/9606.ENSP00000341662 | Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes; Fatty acid hydroxylase domain co [...] |
| TPD52L3 protein network | https://string-db.org/network/9606.ENSP00000341677 | Belongs to the TPD52 family |
| DTNBP1 protein network | https://string-db.org/network/9606.ENSP00000341680 | Dysbindin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with [...] |
| CCDC15 protein network | https://string-db.org/network/9606.ENSP00000341684 | Coiled-coil domain containing 15 |
| NECAP1 protein network | https://string-db.org/network/9606.ENSP00000341737 | Adaptin ear-binding coat-associated protein 1; Involved in endocytosis; Belongs to the NECAP family |
| ENSA protein network | https://string-db.org/network/9606.ENSP00000341743 | Alpha-endosulfine; Endosulfine alpha |
| BSPH1 protein network | https://string-db.org/network/9606.ENSP00000341762 | Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phosph [...] |
| SPATA16 protein network | https://string-db.org/network/9606.ENSP00000341765 | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion |
| PPP1CC protein network | https://string-db.org/network/9606.ENSP00000341779 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate h [...] |
| ADIPOR1 protein network | https://string-db.org/network/9606.ENSP00000341785 | Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and f [...] |
| BTNL3 protein network | https://string-db.org/network/9606.ENSP00000341787 | Butyrophilin-like protein 3; V-set domain containing; Butyrophilins |
| TCTEX1D4 protein network | https://string-db.org/network/9606.ENSP00000341803 | Tctex1 domain containing 4 |
| PHF10 protein network | https://string-db.org/network/9606.ENSP00000341805 | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is requir [...] |
| SOX18 protein network | https://string-db.org/network/9606.ENSP00000341815 | Transcription factor SOX-18; Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site; SRY-boxes |
| VWC2 protein network | https://string-db.org/network/9606.ENSP00000341819 | Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity) |
| FPR3 protein network | https://string-db.org/network/9606.ENSP00000341821 | N-formyl peptide receptor 3; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutro [...] |
| HNRNPA1 protein network | https://string-db.org/network/9606.ENSP00000341826 | Heterogeneous nuclear ribonucleoprotein A1; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site se [...] |
| TNNI3 protein network | https://string-db.org/network/9606.ENSP00000341838 | Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity |
| ETV7 protein network | https://string-db.org/network/9606.ENSP00000341843 | Transcription factor ETV7; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Isoform A does not seem to have a repressor activity. Isoform C does not seem to have a repressor [...] |
| SH2D6 protein network | https://string-db.org/network/9606.ENSP00000341867 | SH2 domain containing 6 |
| RIOK3 protein network | https://string-db.org/network/9606.ENSP00000341874 | Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)- dependent immune response which plays a critical role in the innate immune response against DNA and RNA vi [...] |
| RPS2 protein network | https://string-db.org/network/9606.ENSP00000341885 | Ribosomal protein S2 |
| RASAL3 protein network | https://string-db.org/network/9606.ENSP00000341905 | RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regul [...] |
| PALM protein network | https://string-db.org/network/9606.ENSP00000341911 | Paralemmin-1; Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation a [...] |
| PTCHD4 protein network | https://string-db.org/network/9606.ENSP00000341914 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, includ [...] |
| SUMF2 protein network | https://string-db.org/network/9606.ENSP00000341938 | Sulfatase-modifying factor 2; Lacks formyl-glycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases b [...] |
| CAV3 protein network | https://string-db.org/network/9606.ENSP00000341940 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-ga [...] |
| ATP13A5 protein network | https://string-db.org/network/9606.ENSP00000341942 | Probable cation-transporting ATPase 13A5; ATPase orphan transporters; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily |
| LRRC66 protein network | https://string-db.org/network/9606.ENSP00000341944 | Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66 |
| LIN54 protein network | https://string-db.org/network/9606.ENSP00000341947 | Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds [...] |
| TP53BP2 protein network | https://string-db.org/network/9606.ENSP00000341957 | Apoptosis-stimulating of p53 protein 2; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transa [...] |
| FOXD4L3 protein network | https://string-db.org/network/9606.ENSP00000341961 | Forkhead box D4 like 3 |
| RSC1A1 protein network | https://string-db.org/network/9606.ENSP00000341963 | Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Als [...] |
| OR51I2 protein network | https://string-db.org/network/9606.ENSP00000341987 | Olfactory receptor 51I2; Odorant receptor; Olfactory receptors, family 51 |
| SPATA31D1 protein network | https://string-db.org/network/9606.ENSP00000341988 | Spermatogenesis-associated protein 31D1; May play a role in spermatogenesis |
| NANOS3 protein network | https://string-db.org/network/9606.ENSP00000341992 | Nanos homolog 3; Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell pro [...] |
| ZNF93 protein network | https://string-db.org/network/9606.ENSP00000342002 | Zinc finger protein 93; Transcription factor specifically required to repress long interspersed nuclear element 1 (L1) retrotransposons: recognizes and binds L1 sequences and repress their expres [...] |
| CYP1A2 protein network | https://string-db.org/network/9606.ENSP00000342007 | Cytochrome P450 1A2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| OR2T27 protein network | https://string-db.org/network/9606.ENSP00000342008 | Olfactory receptor 2T27; Odorant receptor; Olfactory receptors, family 2 |
| DMKN protein network | https://string-db.org/network/9606.ENSP00000342012 | Dermokine; May act as a soluble regulator of keratinocyte differentiation |
| COX19 protein network | https://string-db.org/network/9606.ENSP00000342015 | Cytochrome c oxidase assembly protein COX19; May be required for the assembly of mitochondrial cytochrome c oxidase; Mitochondrial respiratory chain complex assembly factors |
| ZNF189 protein network | https://string-db.org/network/9606.ENSP00000342019 | Zinc finger protein 189; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PRDX6 protein network | https://string-db.org/network/9606.ENSP00000342026 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain or [...] |
| CS protein network | https://string-db.org/network/9606.ENSP00000342056 | Citrate synthase, mitochondrial; Citrate synthase |
| SIMC1 protein network | https://string-db.org/network/9606.ENSP00000342075 | SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 |
| SLPI protein network | https://string-db.org/network/9606.ENSP00000342082 | Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the inflammatory and immune responses after bacterial [...] |
| SPINT1 protein network | https://string-db.org/network/9606.ENSP00000342098 | Kunitz-type protease inhibitor 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) |
| DYRK2 protein network | https://string-db.org/network/9606.ENSP00000342105 | Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of [...] |
| SERPINA12 protein network | https://string-db.org/network/9606.ENSP00000342109 | Serpin A12; Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues; Serpin peptidase inhibitors |
| ICAM4 protein network | https://string-db.org/network/9606.ENSP00000342114 | Intercellular adhesion molecule 4; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins; B [...] |
| HHIPL2 protein network | https://string-db.org/network/9606.ENSP00000342118 | HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family |
| CREB3 protein network | https://string-db.org/network/9606.ENSP00000342136 | Cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound transcription factor that plays a role in the unfolded protein response (UPR). Involved in cell proliferation and [...] |
| NCCRP1 protein network | https://string-db.org/network/9606.ENSP00000342137 | F-box only protein 50; Promotes cell proliferation |
| EVC2 protein network | https://string-db.org/network/9606.ENSP00000342144 | Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryoni [...] |
| TMEM167B protein network | https://string-db.org/network/9606.ENSP00000342148 | Protein kish-B; Involved in the early part of the secretory pathway |
| NCR3 protein network | https://string-db.org/network/9606.ENSP00000342156 | Natural cytotoxicity triggering receptor 3; Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells [...] |
| TMEM221 protein network | https://string-db.org/network/9606.ENSP00000342162 | Transmembrane protein 221 |
| TEX9 protein network | https://string-db.org/network/9606.ENSP00000342169 | Testis-expressed protein 9; Testis expressed 9 |
| SRP72 protein network | https://string-db.org/network/9606.ENSP00000342181 | Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA on [...] |
| LRRIQ4 protein network | https://string-db.org/network/9606.ENSP00000342188 | Leucine rich repeats and IQ motif containing 4 |
| BTNL8 protein network | https://string-db.org/network/9606.ENSP00000342197 | Butyrophilin-like protein 8; May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production; Be [...] |
| KIR2DL3 protein network | https://string-db.org/network/9606.ENSP00000342215 | Killer cell immunoglobulin-like receptor 2DL3; Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis [...] |
| ABCA9 protein network | https://string-db.org/network/9606.ENSP00000342216 | ATP-binding cassette sub-family A member 9; May play a role in monocyte differentiation and lipid homeostasis; Belongs to the ABC transporter superfamily. ABCA family |
| TRPV2 protein network | https://string-db.org/network/9606.ENSP00000342222 | Transient receptor potential cation channel subfamily V member 2; Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, [...] |
| ERBB4 protein network | https://string-db.org/network/9606.ENSP00000342235 | Receptor tyrosine-protein kinase erbB-4; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the hear [...] |
| XAGE5 protein network | https://string-db.org/network/9606.ENSP00000342240 | X antigen family member 5; Belongs to the GAGE family |
| C15orf61 protein network | https://string-db.org/network/9606.ENSP00000342254 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 |
| NUP43 protein network | https://string-db.org/network/9606.ENSP00000342262 | Nucleoporin Nup43; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex [...] |
| SLC25A15 protein network | https://string-db.org/network/9606.ENSP00000342267 | Mitochondrial ornithine transporter 1; Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix; Solute carriers |
| OAS2 protein network | https://string-db.org/network/9606.ENSP00000342278 | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in ot [...] |
| ANKRD55 protein network | https://string-db.org/network/9606.ENSP00000342295 | Ankyrin repeat domain-containing protein 55; Ankyrin repeat domain containing |
| FOXM1 protein network | https://string-db.org/network/9606.ENSP00000342307 | Forkhead box protein M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays a [...] |
| SAMD11 protein network | https://string-db.org/network/9606.ENSP00000342313 | Sterile alpha motif domain-containing protein 11; May play a role in photoreceptor development; Sterile alpha motif domain containing |
| TM7SF3 protein network | https://string-db.org/network/9606.ENSP00000342322 | Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells. Is [...] |
| C10orf32 protein network | https://string-db.org/network/9606.ENSP00000342331 | BLOC-1-related complex subunit 7; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...] |
| FAM180A protein network | https://string-db.org/network/9606.ENSP00000342336 | Protein FAM180A; Family with sequence similarity 180 member A |
| CCNYL1 protein network | https://string-db.org/network/9606.ENSP00000342344 | Cyclin-Y-like protein 1; Cyclin Y like 1; Belongs to the cyclin family |
| OSTN protein network | https://string-db.org/network/9606.ENSP00000342356 | Osteocrin; Hormone that acts as a regulator of dendritic growth in the developing cerebral cortex in response to sensory experience. Induced in the brain following membrane depolarization and inh [...] |
| SNRPD2 protein network | https://string-db.org/network/9606.ENSP00000342374 | Small nuclear ribonucleoprotein Sm D2; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an im [...] |
| PTGES protein network | https://string-db.org/network/9606.ENSP00000342385 | Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2); Belongs to the MAPEG family |
| MESP2 protein network | https://string-db.org/network/9606.ENSP00000342392 | Mesoderm posterior protein 2; Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Regulates a [...] |
| NRN1L protein network | https://string-db.org/network/9606.ENSP00000342411 | Neuritin-like protein; Neuritin 1 like |
| BAZ1B protein network | https://string-db.org/network/9606.ENSP00000342434 | Tyrosine-protein kinase BAZ1B; Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phospho [...] |
| OR5W2 protein network | https://string-db.org/network/9606.ENSP00000342448 | Olfactory receptor 5W2; Odorant receptor; Olfactory receptors, family 5 |
| ATP9A protein network | https://string-db.org/network/9606.ENSP00000342481 | Probable phospholipid-transporting ATPase IIA; ATPase phospholipid transporting 9A |
| TSTD2 protein network | https://string-db.org/network/9606.ENSP00000342499 | Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2; Thiosulfate sulfurtransferase like domain containing 2 |
| PYCR2 protein network | https://string-db.org/network/9606.ENSP00000342502 | Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation [...] |
| CEP97 protein network | https://string-db.org/network/9606.ENSP00000342510 | Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recru [...] |
| IFI6 protein network | https://string-db.org/network/9606.ENSP00000342513 | Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis . However, it has also been shown to have a pro-apoptotic activity . Has [...] |
| SLC35F4 protein network | https://string-db.org/network/9606.ENSP00000342518 | Solute carrier family 35 member F4; Putative solute transporter |
| STMN4 protein network | https://string-db.org/network/9606.ENSP00000342538 | Stathmin-4; Stathmin 4; Stathmins |
| HRH3 protein network | https://string-db.org/network/9606.ENSP00000342560 | Histamine H3 receptor; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and dis [...] |
| TREML4 protein network | https://string-db.org/network/9606.ENSP00000342570 | Trem-like transcript 4 protein; Positively regulates Toll-like receptor TLR7 signaling in macrophages; V-set domain containing |
| FAM221A protein network | https://string-db.org/network/9606.ENSP00000342576 | Protein FAM221A; Family with sequence similarity 221 member A; Belongs to the FAM221 family |
| FAM184A protein network | https://string-db.org/network/9606.ENSP00000342604 | Protein FAM184A; Family with sequence similarity 184 member A |
| ACER2 protein network | https://string-db.org/network/9606.ENSP00000342609 | Alkaline ceramidase 2; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsa [...] |
| EYA1 protein network | https://string-db.org/network/9606.ENSP00000342626 | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that deph [...] |
| AURKAIP1 protein network | https://string-db.org/network/9606.ENSP00000342676 | Aurora kinase A-interacting protein; May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation |
| CXorf67 protein network | https://string-db.org/network/9606.ENSP00000342680 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 |
| CD5 protein network | https://string-db.org/network/9606.ENSP00000342681 | T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation; CD molecules |
| OR2AG2 protein network | https://string-db.org/network/9606.ENSP00000342697 | Olfactory receptor 2AG2; Odorant receptor; Olfactory receptors, family 2 |
| CFAP36 protein network | https://string-db.org/network/9606.ENSP00000342699 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family |
| KRT77 protein network | https://string-db.org/network/9606.ENSP00000342710 | Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family |
| RNF41 protein network | https://string-db.org/network/9606.ENSP00000342755 | E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production o [...] |
| PPM1G protein network | https://string-db.org/network/9606.ENSP00000342778 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family |
| FAM25A protein network | https://string-db.org/network/9606.ENSP00000342790 | Family with sequence similarity 25 member A; Belongs to the FAM25 family |
| PLD1 protein network | https://string-db.org/network/9606.ENSP00000342793 | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulatio [...] |
| FAIM protein network | https://string-db.org/network/9606.ENSP00000342805 | Fas apoptotic inhibitory molecule 1; Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells; Belongs to the FAIM1 family |
| ZNF669 protein network | https://string-db.org/network/9606.ENSP00000342818 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NKX2-3 protein network | https://string-db.org/network/9606.ENSP00000342828 | Homeobox protein Nkx-2.3; Transcription factor; NKL subclass homeoboxes and pseudogenes |
| YPEL1 protein network | https://string-db.org/network/9606.ENSP00000342832 | Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts; Yippee like family |
| OR6C74 protein network | https://string-db.org/network/9606.ENSP00000342836 | Olfactory receptor 6C74; Odorant receptor; Olfactory receptors, family 6 |
| LYSMD4 protein network | https://string-db.org/network/9606.ENSP00000342840 | LysM and putative peptidoglycan-binding domain-containing protein 4; LysM domain containing 4 |
| NOXA1 protein network | https://string-db.org/network/9606.ENSP00000342848 | NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of [...] |
| SERPINA6 protein network | https://string-db.org/network/9606.ENSP00000342850 | Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species; Serpin peptidase inhibitors |
| FERMT2 protein network | https://string-db.org/network/9606.ENSP00000342858 | Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosph [...] |
| POLR2K protein network | https://string-db.org/network/9606.ENSP00000342889 | DNA-directed RNA polymerases I, II, and III subunit RPABC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...] |
| MCPH1 protein network | https://string-db.org/network/9606.ENSP00000342924 | Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex |
| POU1F1 protein network | https://string-db.org/network/9606.ENSP00000342931 | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituita [...] |
| UPK3BL protein network | https://string-db.org/network/9606.ENSP00000342938 | Uroplakin-3b-like protein 1; Uroplakin 3B-like |
| ADCY2 protein network | https://string-db.org/network/9606.ENSP00000342952 | Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and [...] |
| SERINC1 protein network | https://string-db.org/network/9606.ENSP00000342962 | Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family |
| ZNF791 protein network | https://string-db.org/network/9606.ENSP00000342974 | Zinc finger protein 791; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GPR114 protein network | https://string-db.org/network/9606.ENSP00000342981 | Adhesion G-protein coupled receptor G5; Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide- binding protein G(s) subunit alpha and [...] |
| IL19 protein network | https://string-db.org/network/9606.ENSP00000343000 | Interleukin-19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity); Interleukins |
| UBE4B protein network | https://string-db.org/network/9606.ENSP00000343001 | Ubiquitin conjugation factor E4 B; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the [...] |
| B3GALTL protein network | https://string-db.org/network/9606.ENSP00000343002 | Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of protein [...] |
| SP100 protein network | https://string-db.org/network/9606.ENSP00000343023 | Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes includi [...] |
| GNAI1 protein network | https://string-db.org/network/9606.ENSP00000343027 | Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous sig [...] |
| RBM5 protein network | https://string-db.org/network/9606.ENSP00000343054 | RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to t [...] |
| OR2T2 protein network | https://string-db.org/network/9606.ENSP00000343062 | Olfactory receptor 2T2; Odorant receptor; Olfactory receptors, family 2 |
| GOLGA8B protein network | https://string-db.org/network/9606.ENSP00000343064 | Golgin subfamily A member 8B; May be involved in maintaining Golgi structure; Belongs to the GOLGA8 family |
| PRMT7 protein network | https://string-db.org/network/9606.ENSP00000343103 | Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a prefere [...] |
| LAMTOR4 protein network | https://string-db.org/network/9606.ENSP00000343118 | Ragulator complex protein LAMTOR4; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...] |
| ARID3B protein network | https://string-db.org/network/9606.ENSP00000343126 | AT-rich interactive domain-containing protein 3B; Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A; AT-rich inte [...] |
| TRIM29 protein network | https://string-db.org/network/9606.ENSP00000343129 | Tripartite motif-containing protein 29; It is able to complement the radiosensitivity defect of an ataxia telangiectasia (AT) fibroblast cell line; Tripartite motif containing |
| XIRP1 protein network | https://string-db.org/network/9606.ENSP00000343140 | Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization; Belongs to the Xin family |
| PARD6G protein network | https://string-db.org/network/9606.ENSP00000343144 | Partitioning defective 6 homolog gamma; Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The [...] |
| EPB41L3 protein network | https://string-db.org/network/9606.ENSP00000343158 | Band 4.1-like protein 3; Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5; Ery [...] |
| C2orf80 protein network | https://string-db.org/network/9606.ENSP00000343171 | Uncharacterized protein C2orf80; Chromosome 2 open reading frame 80 |
| PRR27 protein network | https://string-db.org/network/9606.ENSP00000343172 | Proline-rich protein 27; Proline rich 27 |
| PPCDC protein network | https://string-db.org/network/9606.ENSP00000343190 | Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine |
| SKOR1 protein network | https://string-db.org/network/9606.ENSP00000343200 | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling; SKI transcriptional corepressors |
| JAK1 protein network | https://string-db.org/network/9606.ENSP00000343204 | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor; FERM domain contai [...] |
| TCL1B protein network | https://string-db.org/network/9606.ENSP00000343223 | T-cell leukemia/lymphoma protein 1B; Enhances the phosphorylation and activation of AKT1 and AKT2; Belongs to the TCL1 family |
| ZBED6CL protein network | https://string-db.org/network/9606.ENSP00000343242 | ZBED6 C-terminal-like protein; ZBED6 C-terminal like |
| DUSP21 protein network | https://string-db.org/network/9606.ENSP00000343244 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphoth [...] |
| HOXA1 protein network | https://string-db.org/network/9606.ENSP00000343246 | Homeobox protein Hox-A1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| SBK1 protein network | https://string-db.org/network/9606.ENSP00000343248 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development |
| KLHL7 protein network | https://string-db.org/network/9606.ENSP00000343273 | Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substr [...] |
| FOXN3 protein network | https://string-db.org/network/9606.ENSP00000343288 | Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints); Forkhead boxes |
| C9orf171 protein network | https://string-db.org/network/9606.ENSP00000343290 | Cilia- and flagella-associated protein 77; Chromosome 9 open reading frame 171 |
| PKN1 protein network | https://string-db.org/network/9606.ENSP00000343325 | Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migr [...] |
| LIPI protein network | https://string-db.org/network/9606.ENSP00000343331 | Lipase member I; Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholi [...] |
| P2RX2 protein network | https://string-db.org/network/9606.ENSP00000343339 | P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) [...] |
| VMAC protein network | https://string-db.org/network/9606.ENSP00000343348 | Vimentin type intermediate filament associated coiled-coil protein |
| VSTM1 protein network | https://string-db.org/network/9606.ENSP00000343366 | V-set and transmembrane domain-containing protein 1; Isoform 2: Behaves as a cytokine, promoting IL17A secretion by CD4+ T-cells, and differentiation and activation of IL17 producing helper T-cel [...] |
| TMPPE protein network | https://string-db.org/network/9606.ENSP00000343398 | Transmembrane protein with metallophosphoesterase domain |
| SEC24C protein network | https://string-db.org/network/9606.ENSP00000343405 | Protein transport protein Sec24C; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| BRE protein network | https://string-db.org/network/9606.ENSP00000343412 | BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to t [...] |
| GPR18 protein network | https://string-db.org/network/9606.ENSP00000343428 | N-arachidonyl glycine receptor; Receptor for endocannabinoid N-arachidonyl glycine (NAGly). However, conflicting results about the role of NAGly as an agonist are reported. Can also be activated [...] |
| YIF1B protein network | https://string-db.org/network/9606.ENSP00000343435 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family |
| SERPINB4 protein network | https://string-db.org/network/9606.ENSP00000343445 | Serpin B4; May act as a protease inhibitor to modulate the host immune response against tumor cells; Serpin peptidase inhibitors |
| LCTL protein network | https://string-db.org/network/9606.ENSP00000343490 | Lactase-like protein; Lactase like; Belongs to the glycosyl hydrolase 1 family. Klotho subfamily |
| C17orf99 protein network | https://string-db.org/network/9606.ENSP00000343493 | Uncharacterized protein C17orf99; Chromosome 17 open reading frame 99 |
| TNFSF13 protein network | https://string-db.org/network/9606.ENSP00000343505 | Tumor necrosis factor ligand superfamily member 13; Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/ma [...] |
| TMEM198 protein network | https://string-db.org/network/9606.ENSP00000343507 | Transmembrane protein 198; Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 t [...] |
| TCEA2 protein network | https://string-db.org/network/9606.ENSP00000343515 | Transcription elongation factor A protein 2; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...] |
| OR1J4 protein network | https://string-db.org/network/9606.ENSP00000343521 | Olfactory receptor 1J4; Odorant receptor; Olfactory receptors, family 1 |
| USP1 protein network | https://string-db.org/network/9606.ENSP00000343526 | Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis [...] |
| USP7 protein network | https://string-db.org/network/9606.ENSP00000343535 | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-u [...] |
| ICMT protein network | https://string-db.org/network/9606.ENSP00000343552 | Protein-S-isoprenylcysteine O-methyltransferase; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues |
| TPSAB1 protein network | https://string-db.org/network/9606.ENSP00000343577 | Tryptase alpha/beta-1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate [...] |
| ZFP30 protein network | https://string-db.org/network/9606.ENSP00000343581 | Zinc finger protein 30 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF606 protein network | https://string-db.org/network/9606.ENSP00000343617 | Zinc finger protein 606; May act as a transcriptional repressor; Zinc fingers C2H2-type |
| HOXA9 protein network | https://string-db.org/network/9606.ENSP00000343619 | Homeobox protein Hox-A9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| PRRC2C protein network | https://string-db.org/network/9606.ENSP00000343629 | Protein PRRC2C; Proline rich coiled-coil 2C |
| FOXN2 protein network | https://string-db.org/network/9606.ENSP00000343633 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes |
| TLDC1 protein network | https://string-db.org/network/9606.ENSP00000343635 | TLD domain-containing protein 1; TBC/LysM-associated domain containing 1 |
| GFRAL protein network | https://string-db.org/network/9606.ENSP00000343636 | GDNF family receptor alpha like |
| RAPGEF5 protein network | https://string-db.org/network/9606.ENSP00000343656 | Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation |
| MCCC2 protein network | https://string-db.org/network/9606.ENSP00000343657 | Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to [...] |
| MAP4K4 protein network | https://string-db.org/network/9606.ENSP00000343658 | Mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstr [...] |
| ASTL protein network | https://string-db.org/network/9606.ENSP00000343674 | Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease f [...] |
| GJA4 protein network | https://string-db.org/network/9606.ENSP00000343676 | Gap junction alpha-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| BTBD8 protein network | https://string-db.org/network/9606.ENSP00000343686 | BTB/POZ domain-containing protein 8; BTB domain containing 8 |
| DPYSL3 protein network | https://string-db.org/network/9606.ENSP00000343690 | Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse a [...] |
| KPNA1 protein network | https://string-db.org/network/9606.ENSP00000343701 | Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| MAGEH1 protein network | https://string-db.org/network/9606.ENSP00000343706 | Melanoma-associated antigen H1; MAGE family member H1 |
| ATR protein network | https://string-db.org/network/9606.ENSP00000343741 | Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA r [...] |
| BROX protein network | https://string-db.org/network/9606.ENSP00000343742 | BRO1 domain-containing protein BROX; BRO1 domain and CAAX motif containing; Belongs to the BROX family |
| CORO2A protein network | https://string-db.org/network/9606.ENSP00000343746 | Coronin-2A; WD repeat domain containing; Belongs to the WD repeat coronin family |
| ADRB3 protein network | https://string-db.org/network/9606.ENSP00000343782 | Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of [...] |
| CDK5RAP2 protein network | https://string-db.org/network/9606.ENSP00000343818 | CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centr [...] |
| OTX2 protein network | https://string-db.org/network/9606.ENSP00000343819 | Homeobox protein OTX2; Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'; Belongs to t [...] |
| UGT1A10 protein network | https://string-db.org/network/9606.ENSP00000343838 | UDP-glucuronosyltransferase 1-10; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...] |
| NEK10 protein network | https://string-db.org/network/9606.ENSP00000343847 | Serine/threonine-protein kinase Nek10; Armadillo-like helical domain containing |
| MRRF protein network | https://string-db.org/network/9606.ENSP00000343867 | Ribosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by rec [...] |
| TMTC4 protein network | https://string-db.org/network/9606.ENSP00000343871 | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family |
| PPA2 protein network | https://string-db.org/network/9606.ENSP00000343885 | Inorganic pyrophosphatase 2, mitochondrial; Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organizati [...] |
| CPTP protein network | https://string-db.org/network/9606.ENSP00000343890 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi s [...] |
| NLRP13 protein network | https://string-db.org/network/9606.ENSP00000343891 | NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family |
| FRMD6 protein network | https://string-db.org/network/9606.ENSP00000343899 | FERM domain containing 6 |
| CPSF4L protein network | https://string-db.org/network/9606.ENSP00000343900 | Putative cleavage and polyadenylation specificity factor subunit 4-like protein; Cleavage and polyadenylation specific factor 4 like; Belongs to the CPSF4/YTH1 family |
| PRELP protein network | https://string-db.org/network/9606.ENSP00000343924 | Prolargin; May anchor basement membranes to the underlying connective tissue; Small leucine rich repeat proteoglycans |
| ESR2 protein network | https://string-db.org/network/9606.ENSP00000343925 | Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) [...] |
| KLHL17 protein network | https://string-db.org/network/9606.ENSP00000343930 | Kelch-like protein 17; Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subseque [...] |
| GPR29 protein network | https://string-db.org/network/9606.ENSP00000343952 | Chemokine (C-C motif) receptor 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 [...] |
| IFNAR2 protein network | https://string-db.org/network/9606.ENSP00000343957 | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activatio [...] |
| PSPC1 protein network | https://string-db.org/network/9606.ENSP00000343966 | Paraspeckle component 1; Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and po [...] |
| SYNGR4 protein network | https://string-db.org/network/9606.ENSP00000344041 | Synaptogyrin-4; Synaptogyrin 4; Synaptogyrins |
| METTL24 protein network | https://string-db.org/network/9606.ENSP00000344071 | Methyltransferase-like protein 24; Methyltransferase like 24 |
| AUTS2 protein network | https://string-db.org/network/9606.ENSP00000344087 | Autism susceptibility gene 2 protein; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many gene [...] |
| ZNF683 protein network | https://string-db.org/network/9606.ENSP00000344095 | Tissue-resident T-cell transcription regulator protein ZNF683; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell [...] |
| OR6N2 protein network | https://string-db.org/network/9606.ENSP00000344101 | Olfactory receptor 6N2; Odorant receptor; Olfactory receptors, family 6 |
| CDH5 protein network | https://string-db.org/network/9606.ENSP00000344115 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| POMGNT2 protein network | https://string-db.org/network/9606.ENSP00000344125 | Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N- acetylglucosaminyltransferase that transfers UDP-N-acetyl-D- glucosamine to the 4-position of the [...] |
| ZNF648 protein network | https://string-db.org/network/9606.ENSP00000344129 | Zinc finger protein 648; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PPP1R32 protein network | https://string-db.org/network/9606.ENSP00000344140 | Protein phosphatase 1 regulatory subunit 32 |
| ABCA2 protein network | https://string-db.org/network/9606.ENSP00000344155 | ATP-binding cassette sub-family A member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development; Belongs to t [...] |
| ZNF136 protein network | https://string-db.org/network/9606.ENSP00000344162 | Zinc finger protein 136; May be involved in transcriptional regulation as a weak repressor when alone, or a potent one when fused with a heterologous protein containing a KRAB B-domain; Belongs t [...] |
| TMEM189-UBE2V1 protein network | https://string-db.org/network/9606.ENSP00000344166 | TMEM189-UBE2V1 readthrough; Belongs to the ubiquitin-conjugating enzyme family |
| GRM8 protein network | https://string-db.org/network/9606.ENSP00000344173 | Metabotropic glutamate receptor 8; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| IL17A protein network | https://string-db.org/network/9606.ENSP00000344192 | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells [...] |
| RHBDL1 protein network | https://string-db.org/network/9606.ENSP00000344206 | Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Rhomboid family |
| TRIM14 protein network | https://string-db.org/network/9606.ENSP00000344208 | Tripartite motif-containing protein 14; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane [...] |
| TP53INP1 protein network | https://string-db.org/network/9606.ENSP00000344215 | Tumor protein p53-inducible nuclear protein 1; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a [...] |
| C1orf162 protein network | https://string-db.org/network/9606.ENSP00000344218 | Transmembrane protein C1orf162; Chromosome 1 open reading frame 162 |
| SUSD4 protein network | https://string-db.org/network/9606.ENSP00000344219 | Sushi domain-containing protein 4; Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bou [...] |
| PDPK1 protein network | https://string-db.org/network/9606.ENSP00000344220 | 3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets i [...] |
| MBTPS1 protein network | https://string-db.org/network/9606.ENSP00000344223 | Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other [...] |
| LRRC43 protein network | https://string-db.org/network/9606.ENSP00000344233 | Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43 |
| ZMAT5 protein network | https://string-db.org/network/9606.ENSP00000344241 | Zinc finger matrin-type 5; U11/U12 di-snRNP |
| LRRC17 protein network | https://string-db.org/network/9606.ENSP00000344242 | Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similar [...] |
| FXYD5 protein network | https://string-db.org/network/9606.ENSP00000344254 | FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis; Belongs to the FXYD family |
| GALNT15 protein network | https://string-db.org/network/9606.ENSP00000344260 | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| DOK4 protein network | https://string-db.org/network/9606.ENSP00000344277 | Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in [...] |
| BSX protein network | https://string-db.org/network/9606.ENSP00000344285 | Brain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. Is essentiel for normal postnatal growth and nursing. Is an essential factor for neuronal [...] |
| PTAR1 protein network | https://string-db.org/network/9606.ENSP00000344299 | Protein prenyltransferase alpha subunit repeat containing 1 |
| OFD1 protein network | https://string-db.org/network/9606.ENSP00000344314 | Oral-facial-digital syndrome 1 protein; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific prot [...] |
| FAM69C protein network | https://string-db.org/network/9606.ENSP00000344331 | Protein FAM69C; Family with sequence similarity 69 member C |
| ATF3 protein network | https://string-db.org/network/9606.ENSP00000344352 | Cyclic AMP-dependent transcription factor ATF-3; This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Re [...] |
| FCF1 protein network | https://string-db.org/network/9606.ENSP00000344393 | rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly |
| LIN28B protein network | https://string-db.org/network/9606.ENSP00000344401 | Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including p [...] |
| FSIP2 protein network | https://string-db.org/network/9606.ENSP00000344403 | Plays a role in spermatogenesis. |
| TAS1R3 protein network | https://string-db.org/network/9606.ENSP00000344411 | Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synth [...] |
| KRTAP1-3 protein network | https://string-db.org/network/9606.ENSP00000344420 | Keratin-associated protein 1-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KIAA0247 protein network | https://string-db.org/network/9606.ENSP00000344424 | Sushi domain-containing protein 6; May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUV [...] |
| IFITM10 protein network | https://string-db.org/network/9606.ENSP00000344430 | Interferon induced transmembrane protein 10 |
| DNAJB13 protein network | https://string-db.org/network/9606.ENSP00000344431 | DnaJ homolog subfamily B member 13; May play a role in the formation of the central complex of ciliary and flagellar axonemes; DNAJ heat shock proteins |
| DOK7 protein network | https://string-db.org/network/9606.ENSP00000344432 | Protein Dok-7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor ( [...] |
| FGD6 protein network | https://string-db.org/network/9606.ENSP00000344446 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating [...] |
| CTNNB1 protein network | https://string-db.org/network/9606.ENSP00000344456 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on [...] |
| PROZ protein network | https://string-db.org/network/9606.ENSP00000344458 | Vitamin K-dependent protein Z; Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa i [...] |
| PEAR1 protein network | https://string-db.org/network/9606.ENSP00000344465 | Platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells; Belongs to the MEGF family |
| SDC3 protein network | https://string-db.org/network/9606.ENSP00000344468 | Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferrin [...] |
| NR4A2 protein network | https://string-db.org/network/9606.ENSP00000344479 | Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during develop [...] |
| JPH1 protein network | https://string-db.org/network/9606.ENSP00000344488 | Junctophilin-1; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...] |
| RNF133 protein network | https://string-db.org/network/9606.ENSP00000344489 | E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity; Ring finger proteins |
| TMEM201 protein network | https://string-db.org/network/9606.ENSP00000344503 | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembra [...] |
| H1F0 protein network | https://string-db.org/network/9606.ENSP00000344504 | Histone H1.0; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation [...] |
| IKZF3 protein network | https://string-db.org/network/9606.ENSP00000344544 | Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, pro [...] |
| SCGB1C1 protein network | https://string-db.org/network/9606.ENSP00000344545 | Secretoglobin family 1C member 1; Secretoglobins |
| ARID1B protein network | https://string-db.org/network/9606.ENSP00000344546 | AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component [...] |
| PTMA protein network | https://string-db.org/network/9606.ENSP00000344547 | Prothymosin alpha; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections |
| CORO6 protein network | https://string-db.org/network/9606.ENSP00000344562 | Coronin-6; WD repeat domain containing; Coronins |
| CLEC12B protein network | https://string-db.org/network/9606.ENSP00000344563 | C-type lectin domain family 12 member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphoryl [...] |
| FIBP protein network | https://string-db.org/network/9606.ENSP00000344572 | Acidic fibroblast growth factor intracellular-binding protein; May be involved in mitogenic function of FGF1. May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo [...] |
| APOL3 protein network | https://string-db.org/network/9606.ENSP00000344577 | Apolipoprotein L3; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins |
| FSCB protein network | https://string-db.org/network/9606.ENSP00000344579 | Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium |
| BTG3 protein network | https://string-db.org/network/9606.ENSP00000344609 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family |
| CCNG1 protein network | https://string-db.org/network/9606.ENSP00000344635 | Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular [...] |
| SLC37A1 protein network | https://string-db.org/network/9606.ENSP00000344648 | Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and transl [...] |
| NF2 protein network | https://string-db.org/network/9606.ENSP00000344666 | Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosi [...] |
| DHRS2 protein network | https://string-db.org/network/9606.ENSP00000344674 | Dehydrogenase/reductase SDR family member 2, mitochondrial; Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione a [...] |
| TOX2 protein network | https://string-db.org/network/9606.ENSP00000344724 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system |
| FAM166A protein network | https://string-db.org/network/9606.ENSP00000344729 | Protein FAM166A; Family with sequence similarity 166 member A |
| INSIG1 protein network | https://string-db.org/network/9606.ENSP00000344741 | Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding protein [...] |
| CCDC37 protein network | https://string-db.org/network/9606.ENSP00000344749 | Cilia- and flagella-associated protein 100; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm |
| ECM2 protein network | https://string-db.org/network/9606.ENSP00000344758 | Extracellular matrix protein 2; Promotes matrix assembly and cell adhesiveness |
| GFI1B protein network | https://string-db.org/network/9606.ENSP00000344782 | Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM [...] |
| NFASC protein network | https://string-db.org/network/9606.ENSP00000344786 | Neurofascin; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions; Fibronectin type I [...] |
| ZNF600 protein network | https://string-db.org/network/9606.ENSP00000344791 | Zinc finger protein 600; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SLC24A2 protein network | https://string-db.org/network/9606.ENSP00000344801 | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapi [...] |
| BSDC1 protein network | https://string-db.org/network/9606.ENSP00000344816 | BSD domain containing 1 |
| CMTM5 protein network | https://string-db.org/network/9606.ENSP00000344819 | CKLF like MARVEL transmembrane domain containing 5; Belongs to the chemokine-like factor family |
| KCNK7 protein network | https://string-db.org/network/9606.ENSP00000344820 | Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as [...] |
| ZNF678 protein network | https://string-db.org/network/9606.ENSP00000344828 | Zinc finger protein 678; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| QPCT protein network | https://string-db.org/network/9606.ENSP00000344829 | Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and [...] |
| SLC25A40 protein network | https://string-db.org/network/9606.ENSP00000344831 | Solute carrier family 25 member 40 |
| HAVCR1 protein network | https://string-db.org/network/9606.ENSP00000344844 | Hepatitis A virus cellular receptor 1; May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). May play a role in kidn [...] |
| FBXL14 protein network | https://string-db.org/network/9606.ENSP00000344855 | F-box/LRR-repeat protein 14; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitin [...] |
| IGFL3 protein network | https://string-db.org/network/9606.ENSP00000344860 | Insulin growth factor-like family member 3; Potential ligand of the IGFLR1 cell membrane receptor |
| C9orf153 protein network | https://string-db.org/network/9606.ENSP00000344865 | Uncharacterized protein C9orf153; Chromosome 9 open reading frame 153 |
| FBXL5 protein network | https://string-db.org/network/9606.ENSP00000344866 | F-box/LRR-repeat protein 5; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradati [...] |
| MYO1F protein network | https://string-db.org/network/9606.ENSP00000344871 | Unconventional myosin-If; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| MAFK protein network | https://string-db.org/network/9606.ENSP00000344903 | Transcription factor MafK; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve [...] |
| CSTL1 protein network | https://string-db.org/network/9606.ENSP00000344907 | Cystatin-like 1; Cystatins, type 2 |
| PTP4A2 protein network | https://string-db.org/network/9606.ENSP00000344909 | Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type I [...] |
| BPIFB6 protein network | https://string-db.org/network/9606.ENSP00000344929 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family |
| DPY19L3 protein network | https://string-db.org/network/9606.ENSP00000344937 | Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family |
| UNC119B protein network | https://string-db.org/network/9606.ENSP00000344942 | Protein unc-119 homolog B; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N- terminally myristoylated proteins and is required for [...] |
| PLEKHG7 protein network | https://string-db.org/network/9606.ENSP00000344961 | Pleckstrin homology and RhoGEF domain containing G7 |
| SPRY4 protein network | https://string-db.org/network/9606.ENSP00000344967 | Protein sprouty homolog 4; Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs [...] |
| DALRD3 protein network | https://string-db.org/network/9606.ENSP00000344989 | DALR anticodon-binding domain-containing protein 3; DALR anticodon binding domain containing 3 |
| PALM3 protein network | https://string-db.org/network/9606.ENSP00000344996 | Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling |
| CRTC1 protein network | https://string-db.org/network/9606.ENSP00000345001 | CREB-regulated transcription coactivator 1; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...] |
| FBLN5 protein network | https://string-db.org/network/9606.ENSP00000345008 | Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes el [...] |
| GSTO2 protein network | https://string-db.org/network/9606.ENSP00000345023 | Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Pa [...] |
| GLI4 protein network | https://string-db.org/network/9606.ENSP00000345024 | GLI family zinc finger 4; Zinc fingers C2H2-type |
| FAM47A protein network | https://string-db.org/network/9606.ENSP00000345029 | Protein FAM47A; Family with sequence similarity 47 member A |
| KCNQ5 protein network | https://string-db.org/network/9606.ENSP00000345055 | Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium condu [...] |
| PRICKLE1 protein network | https://string-db.org/network/9606.ENSP00000345064 | Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogeneti [...] |
| MAP2K3 protein network | https://string-db.org/network/9606.ENSP00000345083 | Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a thr [...] |
| IMPDH1 protein network | https://string-db.org/network/9606.ENSP00000345096 | Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synth [...] |
| C19orf35 protein network | https://string-db.org/network/9606.ENSP00000345102 | Uncharacterized protein PEAK3; Chromosome 19 open reading frame 35 |
| C2orf88 protein network | https://string-db.org/network/9606.ENSP00000345107 | Small membrane A-kinase anchor protein; Binds to type I regulatory subunits of protein kinase A (PKA-RI) and may anchor/target them to the plasma membrane; Belongs to the small membrane AKAP fami [...] |
| CDC42BPG protein network | https://string-db.org/network/9606.ENSP00000345133 | Serine/threonine-protein kinase MRCK gamma; May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, throu [...] |
| NKX2-4 protein network | https://string-db.org/network/9606.ENSP00000345147 | Homeobox protein Nkx-2.4; Probable transcription factor; NKL subclass homeoboxes and pseudogenes |
| OR51F1 protein network | https://string-db.org/network/9606.ENSP00000345163 | Olfactory receptor 51F1; Odorant receptor; Olfactory receptors, family 51 |
| PODNL1 protein network | https://string-db.org/network/9606.ENSP00000345175 | Podocan-like protein 1; Podocan like 1 |
| APOD protein network | https://string-db.org/network/9606.ENSP00000345179 | Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transp [...] |
| OLFM3 protein network | https://string-db.org/network/9606.ENSP00000345192 | Noelin-3; Olfactomedin 3 |
| UBQLN2 protein network | https://string-db.org/network/9606.ENSP00000345195 | Ubiquilin-2; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticul [...] |
| RBPJ protein network | https://string-db.org/network/9606.ENSP00000345206 | Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates [...] |
| USP54 protein network | https://string-db.org/network/9606.ENSP00000345216 | Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family |
| DNER protein network | https://string-db.org/network/9606.ENSP00000345229 | Delta and Notch-like epidermal growth factor-related receptor; Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity) |
| TPM4 protein network | https://string-db.org/network/9606.ENSP00000345230 | Tropomyosin alpha-4 chain; Tropomyosin 4; Tropomyosins |
| SIGLEC10 protein network | https://string-db.org/network/9606.ENSP00000345243 | Sialic acid-binding Ig-like lectin 10; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid (By simi [...] |
| EPB41 protein network | https://string-db.org/network/9606.ENSP00000345259 | Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformabili [...] |
| MGAT3 protein network | https://string-db.org/network/9606.ENSP00000345270 | Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the [...] |
| GPT2 protein network | https://string-db.org/network/9606.ENSP00000345282 | Alanine aminotransferase 2; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate; Belongs to the class-I pyridoxal-phosphate-dependent aminotr [...] |
| NDRG3 protein network | https://string-db.org/network/9606.ENSP00000345292 | Protein NDRG3; NDRG family member 3; Belongs to the NDRG family |
| SH2D4B protein network | https://string-db.org/network/9606.ENSP00000345295 | SH2 domain containing 4B |
| ZNF69 protein network | https://string-db.org/network/9606.ENSP00000345333 | Zinc finger protein 69; Zinc fingers C2H2-type |
| PTGES2 protein network | https://string-db.org/network/9606.ENSP00000345341 | Prostaglandin E synthase 2; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2); Glutaredoxin domain containing |
| CTSL protein network | https://string-db.org/network/9606.ENSP00000345344 | Cathepsin L1; Important for the overall degradation of proteins in lysosomes; Cathepsins |
| HMGB1 protein network | https://string-db.org/network/9606.ENSP00000345347 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone [...] |
| PODXL2 protein network | https://string-db.org/network/9606.ENSP00000345359 | Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with [...] |
| ARPC5L protein network | https://string-db.org/network/9606.ENSP00000345361 | Actin-related protein 2/3 complex subunit 5-like protein; May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating n [...] |
| RTP5 protein network | https://string-db.org/network/9606.ENSP00000345374 | Receptor transporter protein 5 |
| MAFF protein network | https://string-db.org/network/9606.ENSP00000345393 | Transcription factor MafF; Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at partu [...] |
| PAPLN protein network | https://string-db.org/network/9606.ENSP00000345395 | Papilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family |
| SPRED3 protein network | https://string-db.org/network/9606.ENSP00000345405 | Sprouty-related, EVH1 domain-containing protein 3; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase |
| CPSF7 protein network | https://string-db.org/network/9606.ENSP00000345412 | Cleavage and polyadenylation specificity factor subunit 7; Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Binds to cleavage and polyadenylatio [...] |
| ASCL4 protein network | https://string-db.org/network/9606.ENSP00000345420 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins |
| CASKIN1 protein network | https://string-db.org/network/9606.ENSP00000345436 | Caskin-1; May link the scaffolding protein CASK to downstream intracellular effectors; Ankyrin repeat domain containing |
| SAMM50 protein network | https://string-db.org/network/9606.ENSP00000345445 | Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory cha [...] |
| NHLRC1 protein network | https://string-db.org/network/9606.ENSP00000345464 | E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates [...] |
| TMEM215 protein network | https://string-db.org/network/9606.ENSP00000345468 | Transmembrane protein 215 |
| CCDC38 protein network | https://string-db.org/network/9606.ENSP00000345470 | Coiled-coil domain containing 38 |
| ZNF587 protein network | https://string-db.org/network/9606.ENSP00000345479 | Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SH2B3 protein network | https://string-db.org/network/9606.ENSP00000345492 | SH2B adapter protein 3; Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase; Pleckstrin homology domain containing |
| PLSCR1 protein network | https://string-db.org/network/9606.ENSP00000345494 | Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...] |
| PDE4D protein network | https://string-db.org/network/9606.ENSP00000345502 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phospho [...] |
| SLC35F6 protein network | https://string-db.org/network/9606.ENSP00000345528 | Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PD [...] |
| ENO4 protein network | https://string-db.org/network/9606.ENSP00000345555 | Enolase 4; May be required for sperm motility and function; Enolases |
| OR7D2 protein network | https://string-db.org/network/9606.ENSP00000345563 | Olfactory receptor 7D2; Odorant receptor; Olfactory receptors, family 7 |
| E2F1 protein network | https://string-db.org/network/9606.ENSP00000345571 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of ge [...] |
| DNAJB12 protein network | https://string-db.org/network/9606.ENSP00000345575 | DnaJ homolog subfamily B member 12; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded prot [...] |
| MAP3K15 protein network | https://string-db.org/network/9606.ENSP00000345629 | Mitogen-activated protein kinase kinase kinase 15; May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis; Belongs to the protein kinase s [...] |
| ZCCHC13 protein network | https://string-db.org/network/9606.ENSP00000345633 | Zinc finger CCHC-type containing 13 |
| VAPA protein network | https://string-db.org/network/9606.ENSP00000345656 | Vesicle-associated membrane protein-associated protein A; VAMP associated protein A |
| CA7 protein network | https://string-db.org/network/9606.ENSP00000345659 | Carbonic anhydrase 7; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family |
| ILDR1 protein network | https://string-db.org/network/9606.ENSP00000345667 | Immunoglobulin-like domain-containing receptor 1; Putative membrane receptor; Deafness associated genes |
| CTSB protein network | https://string-db.org/network/9606.ENSP00000345672 | Cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Cathepsins |
| GATA2 protein network | https://string-db.org/network/9606.ENSP00000345681 | Endothelial transcription factor GATA-2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'; GATA zinc finge [...] |
| NFYA protein network | https://string-db.org/network/9606.ENSP00000345702 | Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the pro [...] |
| KCNJ11 protein network | https://string-db.org/network/9606.ENSP00000345708 | ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to f [...] |
| NKAPL protein network | https://string-db.org/network/9606.ENSP00000345716 | NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis |
| TOR1A protein network | https://string-db.org/network/9606.ENSP00000345719 | Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Invo [...] |
| ATP7A protein network | https://string-db.org/network/9606.ENSP00000345728 | Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular co [...] |
| DLG1 protein network | https://string-db.org/network/9606.ENSP00000345731 | Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane [...] |
| SCNN1B protein network | https://string-db.org/network/9606.ENSP00000345751 | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and w [...] |
| MTMR2 protein network | https://string-db.org/network/9606.ENSP00000345752 | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bi [...] |
| PFKM protein network | https://string-db.org/network/9606.ENSP00000345771 | ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to [...] |
| TEAD3 protein network | https://string-db.org/network/9606.ENSP00000345772 | Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...] |
| BEND7 protein network | https://string-db.org/network/9606.ENSP00000345773 | BEN domain containing 7 |
| ALDH3A2 protein network | https://string-db.org/network/9606.ENSP00000345774 | Fatty aldehyde dehydrogenase; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbo [...] |
| FZD9 protein network | https://string-db.org/network/9606.ENSP00000345785 | Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulati [...] |
| ZC3H7B protein network | https://string-db.org/network/9606.ENSP00000345793 | Zinc finger CCCH domain-containing protein 7B; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apic [...] |
| KRBOX4 protein network | https://string-db.org/network/9606.ENSP00000345797 | KRAB box domain containing 4 |
| ARHGAP12 protein network | https://string-db.org/network/9606.ENSP00000345808 | Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; Pleckstrin homology domain containing |
| BZRAP1 protein network | https://string-db.org/network/9606.ENSP00000345824 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family |
| PMEPA1 protein network | https://string-db.org/network/9606.ENSP00000345826 | Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix product [...] |
| DPY30 protein network | https://string-db.org/network/9606.ENSP00000345837 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys-4' methylation represents a specific ta [...] |
| ANP32B protein network | https://string-db.org/network/9606.ENSP00000345848 | Acidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression f [...] |
| SPAM1 protein network | https://string-db.org/network/9606.ENSP00000345849 | Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus [...] |
| DUSP9 protein network | https://string-db.org/network/9606.ENSP00000345853 | Dual specificity protein phosphatase 9; Inactivates MAP kinases. Has a specificity for the ERK family |
| GJB4 protein network | https://string-db.org/network/9606.ENSP00000345868 | Gap junction beta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| SLC26A3 protein network | https://string-db.org/network/9606.ENSP00000345873 | Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bic [...] |
| NUP50 protein network | https://string-db.org/network/9606.ENSP00000345895 | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembl [...] |
| LYAR protein network | https://string-db.org/network/9606.ENSP00000345917 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type |
| RPS21 protein network | https://string-db.org/network/9606.ENSP00000345957 | Ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family |
| PGLYRP2 protein network | https://string-db.org/network/9606.ENSP00000345968 | N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity; Belo [...] |
| C1orf168 protein network | https://string-db.org/network/9606.ENSP00000345972 | FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T- cell activation and integrin-mediated T-cell adhesion [...] |
| ENOSF1 protein network | https://string-db.org/network/9606.ENSP00000345974 | Mitochondrial enolase superfamily member 1; Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydr [...] |
| LRFN2 protein network | https://string-db.org/network/9606.ENSP00000345985 | Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 [...] |
| PLCH1 protein network | https://string-db.org/network/9606.ENSP00000345988 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calciu [...] |
| DMPK protein network | https://string-db.org/network/9606.ENSP00000345997 | Myotonin-protein kinase; Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation [...] |
| RPL3 protein network | https://string-db.org/network/9606.ENSP00000346001 | 60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; L ribosomal proteins |
| RPL36AL protein network | https://string-db.org/network/9606.ENSP00000346012 | Belongs to the eukaryotic ribosomal protein eL42 family. |
| RPL27A protein network | https://string-db.org/network/9606.ENSP00000346015 | Ribosomal protein L27a; Belongs to the universal ribosomal protein uL15 family |
| RPL21 protein network | https://string-db.org/network/9606.ENSP00000346027 | 60S ribosomal protein L21; Component of the large ribosomal subunit |
| ANXA2 protein network | https://string-db.org/network/9606.ENSP00000346032 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in he [...] |
| RPLP1 protein network | https://string-db.org/network/9606.ENSP00000346037 | 60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family |
| RPS17 protein network | https://string-db.org/network/9606.ENSP00000346046 | Ribosomal protein S17 |
| RPS3A protein network | https://string-db.org/network/9606.ENSP00000346050 | 40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3; Belongs to the eukaryotic ribosomal protein eS1 family |
| TDRD6 protein network | https://string-db.org/network/9606.ENSP00000346065 | Tudor domain-containing protein 6; Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression; Tudor domain containing |
| RPSA protein network | https://string-db.org/network/9606.ENSP00000346067 | 40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the [...] |
| RPL22L1 protein network | https://string-db.org/network/9606.ENSP00000346080 | Ribosomal protein L22 like 1; Belongs to the eukaryotic ribosomal protein eL22 family |
| RPL22 protein network | https://string-db.org/network/9606.ENSP00000346088 | Ribosomal protein L22; Belongs to the eukaryotic ribosomal protein eL22 family |
| GPX4 protein network | https://string-db.org/network/9606.ENSP00000346103 | Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Coul [...] |
| SLC12A6 protein network | https://string-db.org/network/9606.ENSP00000346112 | Solute carrier family 12 member 6; Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells; Belongs to [...] |
| DDX21 protein network | https://string-db.org/network/9606.ENSP00000346120 | Nucleolar RNA helicase 2; RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from p [...] |
| PLEKHB1 protein network | https://string-db.org/network/9606.ENSP00000346127 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containi [...] |
| SVIP protein network | https://string-db.org/network/9606.ENSP00000346130 | Small VCP interacting protein; Belongs to the SVIP family |
| TBC1D20 protein network | https://string-db.org/network/9606.ENSP00000346139 | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of [...] |
| PRKAA1 protein network | https://string-db.org/network/9606.ENSP00000346148 | 5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular e [...] |
| MAGI2 protein network | https://string-db.org/network/9606.ENSP00000346151 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion pr [...] |
| UCKL1 protein network | https://string-db.org/network/9606.ENSP00000346155 | Uridine-cytidine kinase-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation |
| REG4 protein network | https://string-db.org/network/9606.ENSP00000346158 | Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be inv [...] |
| DUSP19 protein network | https://string-db.org/network/9606.ENSP00000346160 | Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity [...] |
| ETFB protein network | https://string-db.org/network/9606.ENSP00000346173 | Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glut [...] |
| SETDB2 protein network | https://string-db.org/network/9606.ENSP00000346175 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 ( [...] |
| NDUFV3 protein network | https://string-db.org/network/9606.ENSP00000346196 | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...] |
| TAP1 protein network | https://string-db.org/network/9606.ENSP00000346206 | Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold [...] |
| FBXO2 protein network | https://string-db.org/network/9606.ENSP00000346240 | F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradati [...] |
| BPIFA1 protein network | https://string-db.org/network/9606.ENSP00000346251 | BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation [...] |
| PPTC7 protein network | https://string-db.org/network/9606.ENSP00000346255 | Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q . Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation |
| SYT5 protein network | https://string-db.org/network/9606.ENSP00000346265 | Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...] |
| PRAMEF20 protein network | https://string-db.org/network/9606.ENSP00000346275 | PRAME family member 20; Belongs to the PRAME family |
| DUS1L protein network | https://string-db.org/network/9606.ENSP00000346280 | tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs |
| HRCT1 protein network | https://string-db.org/network/9606.ENSP00000346283 | Histidine rich carboxyl terminus 1 |
| SLC6A20 protein network | https://string-db.org/network/9606.ENSP00000346298 | Sodium- and chloride-dependent transporter XTRP3; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. I [...] |
| CRKL protein network | https://string-db.org/network/9606.ENSP00000346300 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing |
| NRDE2 protein network | https://string-db.org/network/9606.ENSP00000346335 | Protein NRDE2 homolog; NRDE-2, necessary for RNA interference, domain containing; Belongs to the NRDE2 family |
| COPS8 protein network | https://string-db.org/network/9606.ENSP00000346340 | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| RFPL1 protein network | https://string-db.org/network/9606.ENSP00000346342 | Ret finger protein like 1; Ring finger proteins |
| ZNF774 protein network | https://string-db.org/network/9606.ENSP00000346348 | Zinc finger protein 774; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| KIAA0586 protein network | https://string-db.org/network/9606.ENSP00000346359 | Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes [...] |
| APBB3 protein network | https://string-db.org/network/9606.ENSP00000346378 | Amyloid-beta A4 precursor protein-binding family B member 3; May modulate the internalization of amyloid-beta precursor protein |
| MEF2A protein network | https://string-db.org/network/9606.ENSP00000346389 | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the ac [...] |
| LRRIQ3 protein network | https://string-db.org/network/9606.ENSP00000346414 | Leucine rich repeats and IQ motif containing 3 |
| ATG7 protein network | https://string-db.org/network/9606.ENSP00000346437 | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG1 [...] |
| LRMP protein network | https://string-db.org/network/9606.ENSP00000346442 | Lymphoid-restricted membrane protein; Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen pr [...] |
| IPO4 protein network | https://string-db.org/network/9606.ENSP00000346453 | Importin-4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...] |
| VPS72 protein network | https://string-db.org/network/9606.ENSP00000346464 | Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AFZ, specifically chaperones H2AFZ and deposits it into nucleosomes. As component [...] |
| WDR91 protein network | https://string-db.org/network/9606.ENSP00000346466 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying [...] |
| ADAMTSL2 protein network | https://string-db.org/network/9606.ENSP00000346478 | ADAMTS-like protein 2; ADAMTS like 2 |
| DDRGK1 protein network | https://string-db.org/network/9606.ENSP00000346483 | DDRGK domain-containing protein 1; Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may [...] |
| MAK protein network | https://string-db.org/network/9606.ENSP00000346484 | Serine/threonine-protein kinase MAK; Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle- [...] |
| PDGFA protein network | https://string-db.org/network/9606.ENSP00000346508 | Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Poten [...] |
| H2AFB2 protein network | https://string-db.org/network/9606.ENSP00000346509 | H2A histone family, member B2; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and co [...] |
| SCN8A protein network | https://string-db.org/network/9606.ENSP00000346534 | Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| KRTAP23-1 protein network | https://string-db.org/network/9606.ENSP00000346536 | Keratin-associated protein 23-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| SMOC2 protein network | https://string-db.org/network/9606.ENSP00000346537 | SPARC-related modular calcium-binding protein 2; Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis; [...] |
| ANXA6 protein network | https://string-db.org/network/9606.ENSP00000346550 | Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Annexins |
| FILIP1L protein network | https://string-db.org/network/9606.ENSP00000346560 | Filamin A-interacting protein 1-like; Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation a [...] |
| OR5H1 protein network | https://string-db.org/network/9606.ENSP00000346575 | Olfactory receptor 5H1; Odorant receptor; Olfactory receptors, family 5 |
| AK5 protein network | https://string-db.org/network/9606.ENSP00000346577 | Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Act [...] |
| STYX protein network | https://string-db.org/network/9606.ENSP00000346599 | Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatio [...] |
| OR8B3 protein network | https://string-db.org/network/9606.ENSP00000346611 | Olfactory receptor 8B3; Odorant receptor; Olfactory receptors, family 8 |
| TYW5 protein network | https://string-db.org/network/9606.ENSP00000346627 | tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at t [...] |
| THRAP3 protein network | https://string-db.org/network/9606.ENSP00000346634 | Thyroid hormone receptor-associated protein 3; Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction compl [...] |
| ERO1LB protein network | https://string-db.org/network/9606.ENSP00000346635 | ERO1-like protein beta; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in or [...] |
| HKDC1 protein network | https://string-db.org/network/9606.ENSP00000346643 | Putative hexokinase HKDC1; Hexokinase domain containing 1 |
| RPS6KL1 protein network | https://string-db.org/network/9606.ENSP00000346644 | Ribosomal protein S6 kinase like 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily |
| OCA2 protein network | https://string-db.org/network/9606.ENSP00000346659 | P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the comp [...] |
| WNK3 protein network | https://string-db.org/network/9606.ENSP00000346667 | Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an ac [...] |
| FYN protein network | https://string-db.org/network/9606.ENSP00000346671 | Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated [...] |
| ELOVL2 protein network | https://string-db.org/network/9606.ENSP00000346693 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| HNRNPA2B1 protein network | https://string-db.org/network/9606.ENSP00000346694 | Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arr [...] |
| BMF protein network | https://string-db.org/network/9606.ENSP00000346697 | Bcl-2-modifying factor; May play a role in apoptosis. Isoform 1 seems to be the main initiator; BCL2 homology region 3 only |
| PES1 protein network | https://string-db.org/network/9606.ENSP00000346725 | Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family |
| ZNF589 protein network | https://string-db.org/network/9606.ENSP00000346729 | Zinc finger protein 589; May play a role in hematopoietic stem/progenitor cell differentiation. May play a role as a DNA binding-dependent transcriptional repressor; Belongs to the krueppel C2H2- [...] |
| ACAP3 protein network | https://string-db.org/network/9606.ENSP00000346733 | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing |
| SND1 protein network | https://string-db.org/network/9606.ENSP00000346762 | Staphylococcal nuclease domain-containing protein 1; Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as [...] |
| UGT1A9 protein network | https://string-db.org/network/9606.ENSP00000346768 | UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity [...] |
| PCDHB11 protein network | https://string-db.org/network/9606.ENSP00000346802 | Protocadherin beta-11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| CRYBA4 protein network | https://string-db.org/network/9606.ENSP00000346805 | Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| PGAP1 protein network | https://string-db.org/network/9606.ENSP00000346809 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic ret [...] |
| ALDH9A1 protein network | https://string-db.org/network/9606.ENSP00000346827 | 4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corres [...] |
| WLS protein network | https://string-db.org/network/9606.ENSP00000346829 | Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular [...] |
| FN1 protein network | https://string-db.org/network/9606.ENSP00000346839 | Fibronectin type III domain containing; Endogenous ligands |
| FAR1 protein network | https://string-db.org/network/9606.ENSP00000346874 | Fatty acyl-CoA reductase 1; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalo [...] |
| NKX2-1 protein network | https://string-db.org/network/9606.ENSP00000346879 | Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the mai [...] |
| GABPA protein network | https://string-db.org/network/9606.ENSP00000346886 | GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene; Belongs to the ETS famil [...] |
| NRD1 protein network | https://string-db.org/network/9606.ENSP00000346890 | Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs; Belongs to the peptidase M16 family |
| SERF1A protein network | https://string-db.org/network/9606.ENSP00000346892 | Small EDRK-rich factor 1A; Belongs to the SERF family |
| TRIM6-TRIM34 protein network | https://string-db.org/network/9606.ENSP00000346916 | May function as antiviral protein and may contribute to the defense against retroviral infections |
| AK2 protein network | https://string-db.org/network/9606.ENSP00000346921 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nuc [...] |
| NAT6 protein network | https://string-db.org/network/9606.ENSP00000346927 | N-acetyltransferase 6; Seems to be involved in N-acetylation. Acts on peptides with a N-terminal Met followed by Asp/Glu/Asn. May act as a tumor suppressor; Belongs to the acetyltransferase famil [...] |
| C6orf120 protein network | https://string-db.org/network/9606.ENSP00000346931 | UPF0669 protein C6orf120; May be involved in induction of apoptosis in CD4(+) T- cells, but not CD8(+) T-cells or hepatocytes |
| TMEM205 protein network | https://string-db.org/network/9606.ENSP00000346954 | Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin |
| SLC25A26 protein network | https://string-db.org/network/9606.ENSP00000346955 | S-adenosylmethionine mitochondrial carrier protein; Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates t [...] |
| SLC38A6 protein network | https://string-db.org/network/9606.ENSP00000346959 | Probable sodium-coupled neutral amino acid transporter 6; Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate; Solute carriers |
| EGFLAM protein network | https://string-db.org/network/9606.ENSP00000346964 | Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the phot [...] |
| TMEM207 protein network | https://string-db.org/network/9606.ENSP00000346981 | Transmembrane protein 207 |
| WAC protein network | https://string-db.org/network/9606.ENSP00000346986 | WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase [...] |
| SCARA5 protein network | https://string-db.org/network/9606.ENSP00000346990 | Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocyto [...] |
| SUV39H2 protein network | https://string-db.org/network/9606.ENSP00000346997 | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys- 9' as substrate. H3 'Lys-9' trimethylatio [...] |
| OR5K4 protein network | https://string-db.org/network/9606.ENSP00000347003 | Olfactory receptor 5K4; Odorant receptor; Olfactory receptors, family 5 |
| CGI-74 protein network | https://string-db.org/network/9606.ENSP00000347005 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain |
| PIP4K2C protein network | https://string-db.org/network/9606.ENSP00000347032 | Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum |
| PLSCR4 protein network | https://string-db.org/network/9606.ENSP00000347038 | Phospholipid scramblase 4; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...] |
| FMOD protein network | https://string-db.org/network/9606.ENSP00000347041 | Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class [...] |
| ZNF649 protein network | https://string-db.org/network/9606.ENSP00000347043 | Zinc finger protein 649; Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathwa [...] |
| PDE5A protein network | https://string-db.org/network/9606.ENSP00000347046 | cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specifi [...] |
| MYL4 protein network | https://string-db.org/network/9606.ENSP00000347055 | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing |
| LARGE protein network | https://string-db.org/network/9606.ENSP00000347088 | LARGE xylosyl- and glucuronyltransferase 1; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phospho [...] |
| H2BFM protein network | https://string-db.org/network/9606.ENSP00000347119 | Histone H2B type F-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| NET1 protein network | https://string-db.org/network/9606.ENSP00000347134 | Neuroepithelial cell-transforming gene 1 protein; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stre [...] |
| ASGR2 protein network | https://string-db.org/network/9606.ENSP00000347140 | Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor rec [...] |
| ATRNL1 protein network | https://string-db.org/network/9606.ENSP00000347152 | Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing |
| HIST1H4J protein network | https://string-db.org/network/9606.ENSP00000347168 | Histone cluster 1 H4 family member j; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| NEIL1 protein network | https://string-db.org/network/9606.ENSP00000347170 | Endonuclease 8-like 1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for [...] |
| HTT protein network | https://string-db.org/network/9606.ENSP00000347184 | Huntingtin; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family |
| KCTD6 protein network | https://string-db.org/network/9606.ENSP00000347188 | BTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal [...] |
| TMEM110 protein network | https://string-db.org/network/9606.ENSP00000347195 | TMEM110-MUSTN1 readthrough; Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma me [...] |
| C5AR1 protein network | https://string-db.org/network/9606.ENSP00000347197 | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity si [...] |
| SRGAP1 protein network | https://string-db.org/network/9606.ENSP00000347198 | SLIT-ROBO Rho GTPase-activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of [...] |
| GPAA1 protein network | https://string-db.org/network/9606.ENSP00000347206 | Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate |
| ENSG00000239810 protein network | https://string-db.org/network/9606.ENSP00000347211 | PRAME family member 11 |
| ENTPD2 protein network | https://string-db.org/network/9606.ENSP00000347213 | Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal exte [...] |
| GPBP1L1 protein network | https://string-db.org/network/9606.ENSP00000347224 | Vasculin-like protein 1; Possible transcription factor |
| BLM protein network | https://string-db.org/network/9606.ENSP00000347232 | Bloom syndrome protein; ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction. Participates in DNA replication and repair. Involved in 5'-end resection of D [...] |
| ITSN2 protein network | https://string-db.org/network/9606.ENSP00000347244 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs [...] |
| MRPL52 protein network | https://string-db.org/network/9606.ENSP00000347277 | Mitochondrial ribosomal protein L52 |
| C2orf27A protein network | https://string-db.org/network/9606.ENSP00000347298 | Uncharacterized protein C2orf27; Chromosome 2 open reading frame 27A |
| C6orf89 protein network | https://string-db.org/network/9606.ENSP00000347322 | Bombesin receptor-activated protein C6orf89; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells |
| MSRB3 protein network | https://string-db.org/network/9606.ENSP00000347324 | Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes |
| ZNF607 protein network | https://string-db.org/network/9606.ENSP00000347338 | Zinc finger protein 607; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| POLR3H protein network | https://string-db.org/network/9606.ENSP00000347345 | DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| MAGEA11 protein network | https://string-db.org/network/9606.ENSP00000347358 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal d [...] |
| OCLN protein network | https://string-db.org/network/9606.ENSP00000347379 | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. It is able to induce adhesion when expressed in cells lacking tight junctio [...] |
| AP3M1 protein network | https://string-db.org/network/9606.ENSP00000347408 | AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral struct [...] |
| KEL protein network | https://string-db.org/network/9606.ENSP00000347409 | Kell blood group glycoprotein; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3; Blood group antigens |
| AP3D1 protein network | https://string-db.org/network/9606.ENSP00000347416 | AP-3 complex subunit delta-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral str [...] |
| OR5H2 protein network | https://string-db.org/network/9606.ENSP00000347418 | Olfactory receptor 5H2; Odorant receptor; Olfactory receptors, family 5 |
| MINK1 protein network | https://string-db.org/network/9606.ENSP00000347427 | Misshapen-like kinase 1; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. R [...] |
| OR2L5 protein network | https://string-db.org/network/9606.ENSP00000347428 | Olfactory receptor 2L5; Odorant receptor; Olfactory receptors, family 2 |
| APCDD1 protein network | https://string-db.org/network/9606.ENSP00000347433 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt an [...] |
| TDRD7 protein network | https://string-db.org/network/9606.ENSP00000347444 | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and reg [...] |
| LINGO1 protein network | https://string-db.org/network/9606.ENSP00000347451 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation resp [...] |
| ANO1 protein network | https://string-db.org/network/9606.ENSP00000347454 | Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial [...] |
| GIT2 protein network | https://string-db.org/network/9606.ENSP00000347464 | ARF GTPase-activating protein GIT2; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing |
| THSD4 protein network | https://string-db.org/network/9606.ENSP00000347484 | Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active [...] |
| MORN3 protein network | https://string-db.org/network/9606.ENSP00000347486 | MORN repeat containing 3 |
| WARS protein network | https://string-db.org/network/9606.ENSP00000347495 | Tryptophan--tRNA ligase, cytoplasmic; Isoform 1, isoform 2 and T1-TrpRS have aminoacylation activity while T2-TrpRS lacks it. Isoform 2, T1-TrpRS and T2-TrpRS possess angiostatic activity whereas [...] |
| ZFYVE19 protein network | https://string-db.org/network/9606.ENSP00000347498 | Abscission/NoCut checkpoint regulator; Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolu [...] |
| MYH7 protein network | https://string-db.org/network/9606.ENSP00000347507 | Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute [...] |
| KIAA1598 protein network | https://string-db.org/network/9606.ENSP00000347532 | Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch enga [...] |
| SYT17 protein network | https://string-db.org/network/9606.ENSP00000347538 | Synaptotagmin-17; Plays a role in dendrite formation by melanocytes; Belongs to the synaptotagmin family |
| RNF220 protein network | https://string-db.org/network/9606.ENSP00000347548 | E3 ubiquitin-protein ligase RNF220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, act [...] |
| AGK protein network | https://string-db.org/network/9606.ENSP00000347581 | Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does [...] |
| MFSD12 protein network | https://string-db.org/network/9606.ENSP00000347583 | Major facilitator superfamily domain containing 12 |
| CCDC69 protein network | https://string-db.org/network/9606.ENSP00000347586 | Coiled-coil domain-containing protein 69; May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spin [...] |
| GFRA1 protein network | https://string-db.org/network/9606.ENSP00000347591 | GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity); Belongs to the GDNFR family |
| ARID4A protein network | https://string-db.org/network/9606.ENSP00000347602 | AT-rich interactive domain-containing protein 4A; Interacts with the viral protein-binding domain of the retinoblastoma protein; AT-rich interaction domain containing |
| NUDCD3 protein network | https://string-db.org/network/9606.ENSP00000347626 | NudC domain containing 3 |
| KRTAP13-1 protein network | https://string-db.org/network/9606.ENSP00000347635 | Keratin-associated protein 13-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| SOX12 protein network | https://string-db.org/network/9606.ENSP00000347646 | Transcription factor SOX-12; Binds to the sequence 5'-AACAAT-3'; SRY-boxes |
| ZNF512 protein network | https://string-db.org/network/9606.ENSP00000347648 | Zinc finger protein 512; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LEPREL4 protein network | https://string-db.org/network/9606.ENSP00000347649 | Endoplasmic reticulum protein SC65; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly [...] |
| COL18A1 protein network | https://string-db.org/network/9606.ENSP00000347665 | Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube; Belongs to the multiplexin collagen family |
| VANGL1 protein network | https://string-db.org/network/9606.ENSP00000347672 | VANGL planar cell polarity protein 1 |
| LMX1B protein network | https://string-db.org/network/9606.ENSP00000347684 | LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels; LIM class homeoboxes |
| PDE4C protein network | https://string-db.org/network/9606.ENSP00000347689 | cAMP-specific 3',5'-cyclic phosphodiesterase 4C; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phospho [...] |
| OPHN1 protein network | https://string-db.org/network/9606.ENSP00000347710 | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in s [...] |
| C2CD4A protein network | https://string-db.org/network/9606.ENSP00000347712 | C2 calcium-dependent domain-containing protein 4A; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family |
| FCAR protein network | https://string-db.org/network/9606.ENSP00000347714 | Immunoglobulin alpha Fc receptor; Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production; CD molecules |
| DPF1 protein network | https://string-db.org/network/9606.ENSP00000347716 | D4 zinc and double PHD fingers family 1 variant 4; Double PHD fingers 1; BAF complex |
| DHCR7 protein network | https://string-db.org/network/9606.ENSP00000347717 | 7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC); Belongs to the ERG4/ERG24 family |
| TBCD protein network | https://string-db.org/network/9606.ENSP00000347719 | Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtub [...] |
| SPNS3 protein network | https://string-db.org/network/9606.ENSP00000347721 | Protein spinster homolog 3; Sphingolipid transporter |
| ZNF536 protein network | https://string-db.org/network/9606.ENSP00000347730 | Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA- 3'; Zinc fingers C2H2-type |
| ENSG00000213599 protein network | https://string-db.org/network/9606.ENSP00000347739 | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephr [...] |
| PDZD3 protein network | https://string-db.org/network/9606.ENSP00000347742 | Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9 [...] |
| TPRA1 protein network | https://string-db.org/network/9606.ENSP00000347748 | Transmembrane protein adipocyte associated 1; 7TM orphan receptors |
| HTR3A protein network | https://string-db.org/network/9606.ENSP00000347754 | 5-hydroxytryptamine receptor 3A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| ZNF140 protein network | https://string-db.org/network/9606.ENSP00000347755 | Zinc finger protein 140; May be involved in transcriptional regulation as a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family |
| NEK5 protein network | https://string-db.org/network/9606.ENSP00000347767 | Serine/threonine-protein kinase Nek5; NIMA related kinase 5; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily |
| SYNJ2 protein network | https://string-db.org/network/9606.ENSP00000347792 | Synaptojanin-2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis; Belongs t [...] |
| ANKRD35 protein network | https://string-db.org/network/9606.ENSP00000347802 | Ankyrin repeat domain-containing protein 35; Ankyrin repeat domain containing |
| DEFB107B protein network | https://string-db.org/network/9606.ENSP00000347810 | Beta-defensin 107; Has antibacterial activity; Defensins, beta |
| MORC4 protein network | https://string-db.org/network/9606.ENSP00000347821 | MORC family CW-type zinc finger 4 |
| KRT39 protein network | https://string-db.org/network/9606.ENSP00000347823 | Keratin, type I cytoskeletal 39; May play a role in late hair differentiation; Belongs to the intermediate filament family |
| FBXL3 protein network | https://string-db.org/network/9606.ENSP00000347834 | F-box/LRR-repeat protein 3; Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the sp [...] |
| UBE2H protein network | https://string-db.org/network/9606.ENSP00000347836 | Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitinat [...] |
| RAB11FIP2 protein network | https://string-db.org/network/9606.ENSP00000347839 | Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the tran [...] |
| MKL1 protein network | https://string-db.org/network/9606.ENSP00000347847 | MKL/myocardin-like protein 1; Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activatio [...] |
| SORBS2 protein network | https://string-db.org/network/9606.ENSP00000347852 | Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex w [...] |
| VAT1 protein network | https://string-db.org/network/9606.ENSP00000347872 | Synaptic vesicle membrane protein VAT-1 homolog; Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect [...] |
| PLEKHA7 protein network | https://string-db.org/network/9606.ENSP00000347883 | Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with KIAA1543/Nezha, which anchors microtubules at their [...] |
| MBD6 protein network | https://string-db.org/network/9606.ENSP00000347896 | Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro); Methyl-CpG binding domain containing |
| TTC30A protein network | https://string-db.org/network/9606.ENSP00000347915 | Tetratricopeptide repeat protein 30A; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are tra [...] |
| CLEC12A protein network | https://string-db.org/network/9606.ENSP00000347916 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases; C-type lectin domain containing |
| COA4 protein network | https://string-db.org/network/9606.ENSP00000347919 | Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Putative COX assembly factor; Belongs to the COA4 family |
| SFXN4 protein network | https://string-db.org/network/9606.ENSP00000347924 | Sideroflexin-4; Potential iron transporter; Belongs to the sideroflexin family |
| PCNXL3 protein network | https://string-db.org/network/9606.ENSP00000347931 | Pecanex-like 3 (Drosophila); Belongs to the pecanex family |
| PLGLB1 protein network | https://string-db.org/network/9606.ENSP00000347933 | Plasminogen-like B1; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin to plasm [...] |
| RET protein network | https://string-db.org/network/9606.ENSP00000347942 | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, a [...] |
| TNFRSF14 protein network | https://string-db.org/network/9606.ENSP00000347948 | Tumor necrosis factor receptor superfamily member 14; Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an importan [...] |
| OR2T6 protein network | https://string-db.org/network/9606.ENSP00000347965 | Olfactory receptor 2T6; Odorant receptor; Olfactory receptors, family 2 |
| ERCC5 protein network | https://string-db.org/network/9606.ENSP00000347978 | DNA repair protein complementing XP-G cells; Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Act [...] |
| FAS protein network | https://string-db.org/network/9606.ENSP00000347979 | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling com [...] |
| UBQLN3 protein network | https://string-db.org/network/9606.ENSP00000347997 | Ubiquilin-3; Ubiquilin family |
| PRPF39 protein network | https://string-db.org/network/9606.ENSP00000348010 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family |
| SLC17A5 protein network | https://string-db.org/network/9606.ENSP00000348019 | Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Medi [...] |
| MLH3 protein network | https://string-db.org/network/9606.ENSP00000348020 | DNA mismatch repair protein Mlh3; Probably involved in the repair of mismatches in DNA; MutL homologs |
| OR11L1 protein network | https://string-db.org/network/9606.ENSP00000348033 | Olfactory receptor 11L1; Odorant receptor; Olfactory receptors, family 11 |
| LRRC20 protein network | https://string-db.org/network/9606.ENSP00000348043 | Leucine-rich repeat-containing protein 20; Leucine rich repeat containing 20 |
| MXRA7 protein network | https://string-db.org/network/9606.ENSP00000348050 | Matrix-remodeling-associated protein 7; Matrix remodeling associated 7 |
| COMMD6 protein network | https://string-db.org/network/9606.ENSP00000348054 | COMM domain containing 6; CCC complex |
| UBE2I protein network | https://string-db.org/network/9606.ENSP00000348056 | SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with th [...] |
| ART3 protein network | https://string-db.org/network/9606.ENSP00000348064 | ADP-ribosyltransferase 3 |
| SREBF1 protein network | https://string-db.org/network/9606.ENSP00000348069 | Sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser d [...] |
| CLEC9A protein network | https://string-db.org/network/9606.ENSP00000348074 | C-type lectin domain family 9 member A; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes fil [...] |
| FAM227A protein network | https://string-db.org/network/9606.ENSP00000348086 | Protein FAM227A; Family with sequence similarity 227 member A |
| ERCC6 protein network | https://string-db.org/network/9606.ENSP00000348089 | DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the tr [...] |
| PDLIM7 protein network | https://string-db.org/network/9606.ENSP00000348099 | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding pro [...] |
| C1D protein network | https://string-db.org/network/9606.ENSP00000348107 | Nuclear nucleic acid-binding protein C1D; Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MP [...] |
| KHDRBS3 protein network | https://string-db.org/network/9606.ENSP00000348108 | KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site select [...] |
| SVIL protein network | https://string-db.org/network/9606.ENSP00000348128 | Supervillin; Isoform 1: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myog [...] |
| WDR88 protein network | https://string-db.org/network/9606.ENSP00000348129 | WD repeat-containing protein 88; WD repeat domain containing |
| STK31 protein network | https://string-db.org/network/9606.ENSP00000348132 | Serine/threonine kinase 31; Tudor domain containing |
| C14orf178 protein network | https://string-db.org/network/9606.ENSP00000348145 | Uncharacterized protein C14orf178; Chromosome 14 open reading frame 178 |
| GPR160 protein network | https://string-db.org/network/9606.ENSP00000348161 | Probable G-protein coupled receptor 160; Orphan receptor; G protein-coupled receptors, Class A orphans |
| PLS3 protein network | https://string-db.org/network/9606.ENSP00000348163 | Plastin-3; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. May play a role in the regulation of bone development; EF-hand domain containing |
| GTF2E2 protein network | https://string-db.org/network/9606.ENSP00000348168 | Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFI [...] |
| HP protein network | https://string-db.org/network/9606.ENSP00000348170 | Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepati [...] |
| SLMO2 protein network | https://string-db.org/network/9606.ENSP00000348206 | PRELI domain containing protein 3B; Slowmo homolog 2 (Drosophila) |
| SLC25A46 protein network | https://string-db.org/network/9606.ENSP00000348211 | Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| SH3PXD2A protein network | https://string-db.org/network/9606.ENSP00000348215 | SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metal [...] |
| TRIM4 protein network | https://string-db.org/network/9606.ENSP00000348216 | E3 ubiquitin-protein ligase TRIM4; E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradati [...] |
| TAT protein network | https://string-db.org/network/9606.ENSP00000348234 | Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate a [...] |
| STK39 protein network | https://string-db.org/network/9606.ENSP00000348278 | STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibiton of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffold [...] |
| TRIM13 protein network | https://string-db.org/network/9606.ENSP00000348299 | E3 ubiquitin-protein ligase TRIM13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associat [...] |
| BTG4 protein network | https://string-db.org/network/9606.ENSP00000348300 | Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest; BTG/Tob family |
| MMP23B protein network | https://string-db.org/network/9606.ENSP00000348308 | Matrix metalloproteinase-23; Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity); Immunoglobulin like domain co [...] |
| SPEF2 protein network | https://string-db.org/network/9606.ENSP00000348314 | Sperm flagellar protein 2; Required for correct axoneme development |
| HN1 protein network | https://string-db.org/network/9606.ENSP00000348316 | Jupiter microtubule associated homolog 1; Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser [...] |
| ATP11AUN protein network | https://string-db.org/network/9606.ENSP00000348337 | Putative protein ATP11AUN; ATP11A upstream neighbor |
| MYO9A protein network | https://string-db.org/network/9606.ENSP00000348349 | Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho activity in neurons, has a role in [...] |
| OR52R1 protein network | https://string-db.org/network/9606.ENSP00000348368 | Olfactory receptor 52R1; Odorant receptor; Olfactory receptors, family 52 |
| CYP20A1 protein network | https://string-db.org/network/9606.ENSP00000348380 | Cytochrome P450 family 20 subfamily A member 1 |
| ADD3 protein network | https://string-db.org/network/9606.ENSP00000348381 | Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldol [...] |
| COL27A1 protein network | https://string-db.org/network/9606.ENSP00000348385 | Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone; Belongs to the fibrillar collagen family |
| NPEPL1 protein network | https://string-db.org/network/9606.ENSP00000348395 | Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N- terminal amino acids from various peptides; Aminopeptidases |
| ZNF44 protein network | https://string-db.org/network/9606.ENSP00000348419 | Zinc finger protein 44; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ACSL5 protein network | https://string-db.org/network/9606.ENSP00000348429 | Long-chain-fatty-acid--CoA ligase 5; Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatt [...] |
| PSMD12 protein network | https://string-db.org/network/9606.ENSP00000348442 | 26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...] |
| ANO2 protein network | https://string-db.org/network/9606.ENSP00000348453 | Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in c [...] |
| UVRAG protein network | https://string-db.org/network/9606.ENSP00000348455 | UV radiation resistance-associated gene protein; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the [...] |
| ACMSD protein network | https://string-db.org/network/9606.ENSP00000348459 | 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non [...] |
| NPAS3 protein network | https://string-db.org/network/9606.ENSP00000348460 | Neuronal PAS domain-containing protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness (By similarity); Basic helix-lo [...] |
| RAC1 protein network | https://string-db.org/network/9606.ENSP00000348461 | Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of [...] |
| SH3YL1 protein network | https://string-db.org/network/9606.ENSP00000348471 | SH3 domain-containing YSC84-like protein 1; SH3 and SYLF domain containing 1 |
| PXK protein network | https://string-db.org/network/9606.ENSP00000348472 | PX domain-containing protein kinase-like protein; Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and [...] |
| FBRS protein network | https://string-db.org/network/9606.ENSP00000348489 | Probable fibrosin-1; Fibrosin |
| SUN5 protein network | https://string-db.org/network/9606.ENSP00000348496 | SUN domain-containing protein 5; May be involved in meiotic stage of spermatogenesis |
| GTF3C1 protein network | https://string-db.org/network/9606.ENSP00000348510 | General transcription factor 3C polypeptide 1; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required fo [...] |
| GJB6 protein network | https://string-db.org/network/9606.ENSP00000348521 | Gap junction beta-6 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| CENPL protein network | https://string-db.org/network/9606.ENSP00000348527 | Centromere protein L; Constitutive centromere associated network |
| RBM38 protein network | https://string-db.org/network/9606.ENSP00000348538 | RNA-binding protein 38; RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p [...] |
| CDAN1 protein network | https://string-db.org/network/9606.ENSP00000348564 | Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly |
| UBA5 protein network | https://string-db.org/network/9606.ENSP00000348565 | Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2; Ubiquitin like modifier activating enzymes |
| AKAP9 protein network | https://string-db.org/network/9606.ENSP00000348573 | A-kinase anchor protein 9; Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi appar [...] |
| SDAD1 protein network | https://string-db.org/network/9606.ENSP00000348596 | Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family |
| AMPH protein network | https://string-db.org/network/9606.ENSP00000348602 | Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton; N-BAR domain c [...] |
| RBCK1 protein network | https://string-db.org/network/9606.ENSP00000348632 | RanBP-type and C3HC4-type zinc finger-containing protein 1; E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then tra [...] |
| AMICA1 protein network | https://string-db.org/network/9606.ENSP00000348635 | Junctional adhesion molecule-like; Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane recepto [...] |
| TMPRSS11F protein network | https://string-db.org/network/9606.ENSP00000348639 | Transmembrane protease serine 11F; Probable serine protease |
| PXDNL protein network | https://string-db.org/network/9606.ENSP00000348645 | Peroxidasin-like protein; Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs; I-set doma [...] |
| ZNF770 protein network | https://string-db.org/network/9606.ENSP00000348673 | Zinc finger protein 770; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| UPF2 protein network | https://string-db.org/network/9606.ENSP00000348708 | Regulator of nonsense transcripts 2; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by [...] |
| AREL1 protein network | https://string-db.org/network/9606.ENSP00000348714 | Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfe [...] |
| PUS7 protein network | https://string-db.org/network/9606.ENSP00000348722 | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs . Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from t [...] |
| BTN3A2 protein network | https://string-db.org/network/9606.ENSP00000348751 | Butyrophilin subfamily 3 member A2; Plays a role in T-cell responses in the adaptive immune response. Inhibits the release of IFNG from activated T-cells; Belongs to the immunoglobulin superfamil [...] |
| ORAI2 protein network | https://string-db.org/network/9606.ENSP00000348752 | Protein orai-2; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)- selective current by synergy with the Ca(2+) sensor, STIM1; O [...] |
| SPRED2 protein network | https://string-db.org/network/9606.ENSP00000348753 | Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases |
| CCDC151 protein network | https://string-db.org/network/9606.ENSP00000348757 | Coiled-coil domain-containing protein 151; Ciliary protein involved in outer dynein arm assembly and required for motile cilia function |
| ARIH2 protein network | https://string-db.org/network/9606.ENSP00000348769 | E3 ubiquitin-protein ligase ARIH2; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubi [...] |
| PITPNM1 protein network | https://string-db.org/network/9606.ENSP00000348772 | Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in [...] |
| ACOX3 protein network | https://string-db.org/network/9606.ENSP00000348775 | Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids; Belongs to the acyl-CoA oxidase family |
| MYOM1 protein network | https://string-db.org/network/9606.ENSP00000348821 | Myomesin-1; Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent; Fibronectin type III domain containing |
| ARHGEF26 protein network | https://string-db.org/network/9606.ENSP00000348828 | Rho guanine nucleotide exchange factor 26; Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the [...] |
| UBE2C protein network | https://string-db.org/network/9606.ENSP00000348838 | Ubiquitin-conjugating enzyme E2 C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitinat [...] |
| EML6 protein network | https://string-db.org/network/9606.ENSP00000348842 | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing |
| WDR45 protein network | https://string-db.org/network/9606.ENSP00000348848 | WD repeat domain phosphoinositide-interacting protein 4; Plays an important role in the autophagy pathway, which is the major intracellular degradation system by which cytoplasmic materials are p [...] |
| RPS26 protein network | https://string-db.org/network/9606.ENSP00000348849 | Ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family |
| STOML2 protein network | https://string-db.org/network/9606.ENSP00000348886 | Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enric [...] |
| PIGR protein network | https://string-db.org/network/9606.ENSP00000348888 | Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the [...] |
| AADACL2 protein network | https://string-db.org/network/9606.ENSP00000348911 | Arylacetamide deacetylase-like 2; Arylacetamide deacetylase family; Belongs to the 'GDXG' lipolytic enzyme family |
| ADAM33 protein network | https://string-db.org/network/9606.ENSP00000348912 | Disintegrin and metalloproteinase domain-containing protein 33; ADAM metallopeptidase domain containing |
| HIST1H2BF protein network | https://string-db.org/network/9606.ENSP00000348924 | Histone cluster 1 H2B family member f; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| CCDC25 protein network | https://string-db.org/network/9606.ENSP00000348933 | Coiled-coil domain containing 25; Belongs to the CCDC25 family |
| RSPO1 protein network | https://string-db.org/network/9606.ENSP00000348944 | R-spondin-1; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 an [...] |
| MAN1A2 protein network | https://string-db.org/network/9606.ENSP00000348959 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce [...] |
| DYNC1H1 protein network | https://string-db.org/network/9606.ENSP00000348965 | Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the f [...] |
| WFDC11 protein network | https://string-db.org/network/9606.ENSP00000348968 | Protein WFDC11; WAP four-disulfide core domain containing |
| MEGF6 protein network | https://string-db.org/network/9606.ENSP00000348982 | Multiple epidermal growth factor-like domains protein 6; Multiple EGF like domains 6 |
| SON protein network | https://string-db.org/network/9606.ENSP00000348984 | Protein SON; RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-c [...] |
| PTGER3 protein network | https://string-db.org/network/9606.ENSP00000349003 | Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in ce [...] |
| PEX14 protein network | https://string-db.org/network/9606.ENSP00000349016 | Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic [...] |
| ARC protein network | https://string-db.org/network/9606.ENSP00000349022 | Activity-regulated cytoskeleton-associated protein; Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response [...] |
| NRARP protein network | https://string-db.org/network/9606.ENSP00000349041 | Notch-regulated ankyrin repeat-containing protein; Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstrea [...] |
| ATN1 protein network | https://string-db.org/network/9606.ENSP00000349076 | Atrophin-1; Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcription [...] |
| FDPS protein network | https://string-db.org/network/9606.ENSP00000349078 | Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites includ [...] |
| MAGEA1 protein network | https://string-db.org/network/9606.ENSP00000349085 | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) [...] |
| TMEM259 protein network | https://string-db.org/network/9606.ENSP00000349087 | Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against E [...] |
| PPP4R2 protein network | https://string-db.org/network/9606.ENSP00000349124 | Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule orga [...] |
| RSPO3 protein network | https://string-db.org/network/9606.ENSP00000349131 | R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6 [...] |
| ATP5C1 protein network | https://string-db.org/network/9606.ENSP00000349142 | ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...] |
| BTN2A2 protein network | https://string-db.org/network/9606.ENSP00000349143 | Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin [...] |
| CNNM1 protein network | https://string-db.org/network/9606.ENSP00000349147 | Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family |
| SIAH1 protein network | https://string-db.org/network/9606.ENSP00000349156 | E3 ubiquitin-protein ligase SIAH1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from a [...] |
| ZNF790 protein network | https://string-db.org/network/9606.ENSP00000349161 | Zinc finger protein 790; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HNRNPH1 protein network | https://string-db.org/network/9606.ENSP00000349168 | Heterogeneous nuclear ribonucleoprotein H; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that [...] |
| HVCN1 protein network | https://string-db.org/network/9606.ENSP00000349181 | Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with the [...] |
| CRB3 protein network | https://string-db.org/network/9606.ENSP00000349204 | Protein crumbs homolog 3; Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions; Crumbs complex |
| PIK3R4 protein network | https://string-db.org/network/9606.ENSP00000349205 | Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a [...] |
| PIWIL2 protein network | https://string-db.org/network/9606.ENSP00000349208 | Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline i [...] |
| CCDC88B protein network | https://string-db.org/network/9606.ENSP00000349238 | Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells, in both the CD4(+) and the CD8(+ [...] |
| EDRF1 protein network | https://string-db.org/network/9606.ENSP00000349244 | Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene |
| ITGAL protein network | https://string-db.org/network/9606.ENSP00000349252 | Integrin alpha-L; Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin alpha-L/beta-2 is also a receptor for F11R. Involved in a variety of immune phenomena including [...] |
| SPTBN1 protein network | https://string-db.org/network/9606.ENSP00000349259 | Spectrin beta chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent m [...] |
| HBM protein network | https://string-db.org/network/9606.ENSP00000349270 | Hemoglobin subunit mu; Belongs to the globin family |
| PPP1R26 protein network | https://string-db.org/network/9606.ENSP00000349274 | Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation |
| TBC1D9B protein network | https://string-db.org/network/9606.ENSP00000349291 | TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing |
| TMEM71 protein network | https://string-db.org/network/9606.ENSP00000349296 | Transmembrane protein 71; Belongs to the TMEM71 family |
| MYLIP protein network | https://string-db.org/network/9606.ENSP00000349298 | E3 ubiquitin-protein ligase MYLIP; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. A [...] |
| GOLGA4 protein network | https://string-db.org/network/9606.ENSP00000349305 | Golgin subfamily A member 4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 |
| NHEJ1 protein network | https://string-db.org/network/9606.ENSP00000349313 | Non-homologous end-joining factor 1; DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a brid [...] |
| CACNA2D1 protein network | https://string-db.org/network/9606.ENSP00000349320 | Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...] |
| TNFRSF10C protein network | https://string-db.org/network/9606.ENSP00000349324 | Tumor necrosis factor receptor superfamily member 10C; Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells [...] |
| ATP10A protein network | https://string-db.org/network/9606.ENSP00000349325 | Probable phospholipid-transporting ATPase VA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...] |
| FAM163B protein network | https://string-db.org/network/9606.ENSP00000349336 | Protein FAM163B; Family with sequence similarity 163 member B |
| BICD2 protein network | https://string-db.org/network/9606.ENSP00000349351 | Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non- processive to a highly processive motor in the presence [...] |
| C12orf29 protein network | https://string-db.org/network/9606.ENSP00000349358 | Uncharacterized protein C12orf29; Chromosome 12 open reading frame 29 |
| SASH3 protein network | https://string-db.org/network/9606.ENSP00000349359 | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes; SAM and SH3 domain containing |
| IL27 protein network | https://string-db.org/network/9606.ENSP00000349365 | Interleukin-27 subunit alpha; Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, tha [...] |
| ABCD4 protein network | https://string-db.org/network/9606.ENSP00000349396 | ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm; A [...] |
| ZNF708 protein network | https://string-db.org/network/9606.ENSP00000349401 | Zinc finger protein 708; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PTBP1 protein network | https://string-db.org/network/9606.ENSP00000349428 | Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell diff [...] |
| HIST1H2BK protein network | https://string-db.org/network/9606.ENSP00000349430 | Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| ADAM15 protein network | https://string-db.org/network/9606.ENSP00000349436 | Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both h [...] |
| IGF2R protein network | https://string-db.org/network/9606.ENSP00000349437 | Cation-independent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl [...] |
| ARG1 protein network | https://string-db.org/network/9606.ENSP00000349446 | Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bio [...] |
| CLCC1 protein network | https://string-db.org/network/9606.ENSP00000349456 | Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel; Tetraspan junctional complex superfamily |
| ICK protein network | https://string-db.org/network/9606.ENSP00000349458 | Serine/threonine-protein kinase ICK; Required for ciliogenesis. Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway [...] |
| SPINK14 protein network | https://string-db.org/network/9606.ENSP00000349459 | Serine protease inhibitor Kazal-type 14; May be a serine protease inhibitor; Serine peptidase inhibitors, Kazal type |
| CALM1 protein network | https://string-db.org/network/9606.ENSP00000349467 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodul [...] |
| KLRG1 protein network | https://string-db.org/network/9606.ENSP00000349477 | Killer cell lectin-like receptor subfamily G member 1; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self r [...] |
| SCRIB protein network | https://string-db.org/network/9606.ENSP00000349486 | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establ [...] |
| MFNG protein network | https://string-db.org/network/9606.ENSP00000349490 | Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of N [...] |
| GUCA2A protein network | https://string-db.org/network/9606.ENSP00000349493 | Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family |
| ZNF254 protein network | https://string-db.org/network/9606.ENSP00000349494 | Zinc finger protein 254; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZBTB14 protein network | https://string-db.org/network/9606.ENSP00000349503 | Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'- CCTGCACAGTTCACGGA-3'. Binds to 5 [...] |
| CHD4 protein network | https://string-db.org/network/9606.ENSP00000349508 | Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones; Belongs to the SNF2/RAD [...] |
| PTRF protein network | https://string-db.org/network/9606.ENSP00000349541 | Caveolae-associated protein 1; Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is [...] |
| PEX2 protein network | https://string-db.org/network/9606.ENSP00000349543 | Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family |
| RASSF1 protein network | https://string-db.org/network/9606.ENSP00000349547 | Ras association domain-containing protein 1; Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apopto [...] |
| RAB4B protein network | https://string-db.org/network/9606.ENSP00000349560 | Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family |
| CFAP43 protein network | https://string-db.org/network/9606.ENSP00000349568 | Cilia and flagella associated protein 43; Belongs to the CFAP43 family |
| MOB3A protein network | https://string-db.org/network/9606.ENSP00000349575 | MOB kinase activator 3A; May regulate the activity of kinases; MOB kinase activators |
| DCTD protein network | https://string-db.org/network/9606.ENSP00000349576 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase |
| POX2 protein network | https://string-db.org/network/9606.ENSP00000349577 | Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family |
| ANK2 protein network | https://string-db.org/network/9606.ENSP00000349588 | Ankyrin-2; In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromus [...] |
| ELAVL4 protein network | https://string-db.org/network/9606.ENSP00000349594 | ELAV-like protein 4; May play a role in neuron-specific RNA processing. Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). Binds to AU-rich sequences (AREs) of target mRNAs [...] |
| ATP2A1 protein network | https://string-db.org/network/9606.ENSP00000349595 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sa [...] |
| TRIM38 protein network | https://string-db.org/network/9606.ENSP00000349596 | E3 ubiquitin-protein ligase TRIM38; E3 ubiquitin-protein ligase. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediat [...] |
| ANKRD7 protein network | https://string-db.org/network/9606.ENSP00000349612 | Ankyrin repeat domain-containing protein 7; Ankyrin repeat domain containing |
| ADIPOR2 protein network | https://string-db.org/network/9606.ENSP00000349616 | Adiponectin receptor protein 2; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. [...] |
| LRBA protein network | https://string-db.org/network/9606.ENSP00000349629 | Lipopolysaccharide-responsive and beige-like anchor protein; May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of im [...] |
| MCRS1 protein network | https://string-db.org/network/9606.ENSP00000349640 | Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal hist [...] |
| XPNPEP3 protein network | https://string-db.org/network/9606.ENSP00000349658 | X-prolyl aminopeptidase 3; Belongs to the peptidase M24B family |
| TEX43 protein network | https://string-db.org/network/9606.ENSP00000349669 | Testis-expressed protein 43; Testis expressed 43 |
| SPOCK3 protein network | https://string-db.org/network/9606.ENSP00000349677 | Testican-3; May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion; SPARC fa [...] |
| MYBPHL protein network | https://string-db.org/network/9606.ENSP00000349678 | Myosin-binding protein H-like; Fibronectin type III domain containing; Belongs to the immunoglobulin superfamily. MyBP family |
| DYNLRB1 protein network | https://string-db.org/network/9606.ENSP00000349679 | Dynein light chain roadblock-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and [...] |
| GM2A protein network | https://string-db.org/network/9606.ENSP00000349687 | Ganglioside GM2 activator; The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By simi [...] |
| ZDHHC9 protein network | https://string-db.org/network/9606.ENSP00000349689 | Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS |
| ZMYM6 protein network | https://string-db.org/network/9606.ENSP00000349708 | Zinc finger MYM-type protein 6; Plays a role in the regulation of cell morphology and cytoskeletal organization; Zinc fingers MYM-type |
| RAET1E protein network | https://string-db.org/network/9606.ENSP00000349709 | Retinoic acid early transcript 1E; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity |
| OR2L8 protein network | https://string-db.org/network/9606.ENSP00000349719 | Olfactory receptor 2L8; Odorant receptor; Olfactory receptors, family 2 |
| UBE2D3 protein network | https://string-db.org/network/9606.ENSP00000349722 | Ubiquitin conjugating enzyme E2 D3; Belongs to the ubiquitin-conjugating enzyme family |
| BCL11B protein network | https://string-db.org/network/9606.ENSP00000349723 | B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopo [...] |
| DOK3 protein network | https://string-db.org/network/9606.ENSP00000349727 | Docking protein 3; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative [...] |
| C3orf18 protein network | https://string-db.org/network/9606.ENSP00000349732 | Uncharacterized protein C3orf18; Chromosome 3 open reading frame 18 |
| SFPQ protein network | https://string-db.org/network/9606.ENSP00000349748 | Splicing factor, proline- and glutamine-rich; DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and f [...] |
| IRF5 protein network | https://string-db.org/network/9606.ENSP00000349770 | Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling; B [...] |
| TBC1D8B protein network | https://string-db.org/network/9606.ENSP00000349781 | TBC1 domain family member 8B; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing |
| MAP1LC3C protein network | https://string-db.org/network/9606.ENSP00000349785 | Microtubule-associated proteins 1A/1B light chain 3C; Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits [...] |
| COL9A1 protein network | https://string-db.org/network/9606.ENSP00000349790 | Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans |
| FAM212B protein network | https://string-db.org/network/9606.ENSP00000349805 | PAK4-inhibitor INKA2; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity; Belongs to the INKA family |
| SMARCAL1 protein network | https://string-db.org/network/9606.ENSP00000349823 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA [...] |
| REPS2 protein network | https://string-db.org/network/9606.ENSP00000349824 | RalBP1-associated Eps domain-containing protein 2; Involved in growth factor signaling through its influence on the Ral signaling pathway; EF-hand domain containing |
| PRRC2B protein network | https://string-db.org/network/9606.ENSP00000349856 | Protein PRRC2B; Proline rich coiled-coil 2B |
| GFPT1 protein network | https://string-db.org/network/9606.ENSP00000349860 | Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N [...] |
| NUDT13 protein network | https://string-db.org/network/9606.ENSP00000349874 | Nucleoside diphosphate-linked moiety X motif 13; Nudix hydrolase family |
| ATP13A1 protein network | https://string-db.org/network/9606.ENSP00000349877 | Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis; Belongs to the cation transpor [...] |
| GALP protein network | https://string-db.org/network/9606.ENSP00000349884 | Galanin-like peptide; Isoform 1: Hypothalamic neuropeptide which binds to the G-protein-coupled galanin receptors (GALR1, GALR2 and GALR3). Involved in a large number of putative physiological fu [...] |
| ANKRD20A4 protein network | https://string-db.org/network/9606.ENSP00000349891 | Ankyrin repeat domain-containing protein 20A4; Ankyrin repeat domain 20 family member A4 |
| DLK2 protein network | https://string-db.org/network/9606.ENSP00000349893 | Protein delta homolog 2; Regulates adipogenesis |
| LAGE3 protein network | https://string-db.org/network/9606.ENSP00000349923 | EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons [...] |
| SDCCAG3 protein network | https://string-db.org/network/9606.ENSP00000349929 | Serologically defined colon cancer antigen 3; May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endos [...] |
| OR11G2 protein network | https://string-db.org/network/9606.ENSP00000349930 | Olfactory receptor 11G2; Odorant receptor; Olfactory receptors, family 11 |
| PRAMEF8 protein network | https://string-db.org/network/9606.ENSP00000349931 | PRAME family member 8; Belongs to the PRAME family |
| PTPRS protein network | https://string-db.org/network/9606.ENSP00000349932 | Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chon [...] |
| OR5B17 protein network | https://string-db.org/network/9606.ENSP00000349945 | Olfactory receptor 5B17; Odorant receptor; Olfactory receptors, family 5 |
| CGB protein network | https://string-db.org/network/9606.ENSP00000349954 | Chorionic gonadotropin, beta polypeptide; Belongs to the glycoprotein hormones subunit beta family |
| ANAPC11 protein network | https://string-db.org/network/9606.ENSP00000349957 | Anaphase promoting complex subunit 11 |
| ACTB protein network | https://string-db.org/network/9606.ENSP00000349960 | Actin, cytoplasmic 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| SMC4 protein network | https://string-db.org/network/9606.ENSP00000349961 | Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The [...] |
| CCRL2 protein network | https://string-db.org/network/9606.ENSP00000349967 | C-C chemokine receptor-like 2; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by captu [...] |
| ERGIC3 protein network | https://string-db.org/network/9606.ENSP00000349970 | Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family |
| CEACAM3 protein network | https://string-db.org/network/9606.ENSP00000349971 | Carcinoembryonic antigen-related cell adhesion molecule 3; Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, includ [...] |
| GIP protein network | https://string-db.org/network/9606.ENSP00000350005 | Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Endogenous ligands |
| ACSL3 protein network | https://string-db.org/network/9606.ENSP00000350012 | Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic [...] |
| SH3BP1 protein network | https://string-db.org/network/9606.ENSP00000350018 | SH3 domain-binding protein 1; GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically ina [...] |
| OR8D2 protein network | https://string-db.org/network/9606.ENSP00000350022 | Olfactory receptor 8D2; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 8 |
| SLC29A2 protein network | https://string-db.org/network/9606.ENSP00000350024 | Equilibrative nucleoside transporter 2; Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitr [...] |
| FRMD4A protein network | https://string-db.org/network/9606.ENSP00000350032 | FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex (By similarity). Plays a redundant role with FRM [...] |
| SMC1B protein network | https://string-db.org/network/9606.ENSP00000350036 | Structural maintenance of chromosomes protein 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its esta [...] |
| HOMEZ protein network | https://string-db.org/network/9606.ENSP00000350049 | Homeobox and leucine zipper protein Homez; May function as a transcriptional regulator; ZF class homeoboxes and pseudogenes |
| TMEM229B protein network | https://string-db.org/network/9606.ENSP00000350050 | Transmembrane protein 229B |
| POTEF protein network | https://string-db.org/network/9606.ENSP00000350052 | POTE ankyrin domain family member F; In the C-terminal section; belongs to the actin family |
| STRN3 protein network | https://string-db.org/network/9606.ENSP00000350071 | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Protein phosphatase 2 regulatory subunits |
| ARPIN protein network | https://string-db.org/network/9606.ENSP00000350075 | Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoher [...] |
| ARID5A protein network | https://string-db.org/network/9606.ENSP00000350078 | AT-rich interactive domain-containing protein 5A; Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repre [...] |
| ZNF43 protein network | https://string-db.org/network/9606.ENSP00000350085 | Zinc finger protein 43; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| HNRNPA1L2 protein network | https://string-db.org/network/9606.ENSP00000350090 | Heterogeneous nuclear ribonucleoprotein A1-like 2; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice [...] |
| POP5 protein network | https://string-db.org/network/9606.ENSP00000350098 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP |
| TOR4A protein network | https://string-db.org/network/9606.ENSP00000350102 | Torsin-4A; Torsin family 4 member A |
| PLN protein network | https://string-db.org/network/9606.ENSP00000350132 | Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of th [...] |
| RIMKLB protein network | https://string-db.org/network/9606.ENSP00000350136 | Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N-acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-as [...] |
| SYCP2 protein network | https://string-db.org/network/9606.ENSP00000350162 | Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Requ [...] |
| FXR1 protein network | https://string-db.org/network/9606.ENSP00000350170 | Fragile X mental retardation syndrome-related protein 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local tran [...] |
| SSTR2 protein network | https://string-db.org/network/9606.ENSP00000350198 | Somatostatin receptor type 2; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates [...] |
| AP1B1 protein network | https://string-db.org/network/9606.ENSP00000350199 | AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP com [...] |
| OR51D1 protein network | https://string-db.org/network/9606.ENSP00000350222 | Olfactory receptor 51D1; Odorant receptor; Olfactory receptors, family 51 |
| DNAJC14 protein network | https://string-db.org/network/9606.ENSP00000350223 | DnaJ homolog subfamily C member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface; DNAJ heat shock proteins |
| BMX protein network | https://string-db.org/network/9606.ENSP00000350224 | Cytoplasmic tyrosine-protein kinase BMX; Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganiza [...] |
| OR14A16 protein network | https://string-db.org/network/9606.ENSP00000350248 | Olfactory receptor 14A16; Odorant receptor; Olfactory receptors, family 14 |
| POT1 protein network | https://string-db.org/network/9606.ENSP00000350249 | Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded t [...] |
| CCR9 protein network | https://string-db.org/network/9606.ENSP00000350256 | C-C chemokine receptor type 9; Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level; Belongs to the G-protein coupled receptor 1 [...] |
| FAM219B protein network | https://string-db.org/network/9606.ENSP00000350260 | Protein FAM219B; Family with sequence similarity 219 member B |
| PIGN protein network | https://string-db.org/network/9606.ENSP00000350263 | GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4- [...] |
| DENND2D protein network | https://string-db.org/network/9606.ENSP00000350266 | DENN domain-containing protein 2D; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...] |
| BRPF3 protein network | https://string-db.org/network/9606.ENSP00000350267 | Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity; Bromodomain containing |
| ZNF816 protein network | https://string-db.org/network/9606.ENSP00000350295 | Zinc finger protein 816; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ATP2B4 protein network | https://string-db.org/network/9606.ENSP00000350310 | Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the ce [...] |
| BCO2 protein network | https://string-db.org/network/9606.ENSP00000350314 | Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, ly [...] |
| ASB13 protein network | https://string-db.org/network/9606.ENSP00000350331 | Ankyrin repeat and SOCS box protein 13; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| MYBPC2 protein network | https://string-db.org/network/9606.ENSP00000350332 | Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin fila [...] |
| SAP130 protein network | https://string-db.org/network/9606.ENSP00000350333 | Histone deacetylase complex subunit SAP130; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interacti [...] |
| DSCR8 protein network | https://string-db.org/network/9606.ENSP00000350336 | Down syndrome critical region 8 |
| GRM7 protein network | https://string-db.org/network/9606.ENSP00000350348 | Metabotropic glutamate receptor 7; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| METTL20 protein network | https://string-db.org/network/9606.ENSP00000350353 | Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negativel [...] |
| PRAMEF12 protein network | https://string-db.org/network/9606.ENSP00000350358 | PRAME family member 12; Belongs to the PRAME family |
| CREB5 protein network | https://string-db.org/network/9606.ENSP00000350359 | Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription; Basic leucine zipper proteins |
| NEGR1 protein network | https://string-db.org/network/9606.ENSP00000350364 | Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans-neural growth-promoting factor in regenerative axon sprouting in the mammalian brain (By similarity); Belong [...] |
| MAFG protein network | https://string-db.org/network/9606.ENSP00000350369 | Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve [...] |
| MCTP2 protein network | https://string-db.org/network/9606.ENSP00000350377 | Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Multiple C2 and transmembrane domain containing |
| GOLGA7 protein network | https://string-db.org/network/9606.ENSP00000350378 | Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS |
| CHM protein network | https://string-db.org/network/9606.ENSP00000350386 | Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate p [...] |
| C17orf102 protein network | https://string-db.org/network/9606.ENSP00000350392 | Uncharacterized protein C17orf102; Chromosome 17 open reading frame 102 |
| HHLA2 protein network | https://string-db.org/network/9606.ENSP00000350402 | HERV-H LTR-associating protein 2; Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT [...] |
| UNC50 protein network | https://string-db.org/network/9606.ENSP00000350409 | Protein unc-50 homolog; May be involved in cell surface expression of neuronal nicotinic receptors. Binds RNA (By similarity) |
| ZNF98 protein network | https://string-db.org/network/9606.ENSP00000350418 | Zinc finger protein 98; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| APOA4 protein network | https://string-db.org/network/9606.ENSP00000350425 | Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a [...] |
| SGOL2 protein network | https://string-db.org/network/9606.ENSP00000350447 | Shugoshin 2; Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres f [...] |
| NAT9 protein network | https://string-db.org/network/9606.ENSP00000350467 | GCN5 related N-acetyltransferases; Belongs to the acetyltransferase family. GNAT subfamily |
| OR8D1 protein network | https://string-db.org/network/9606.ENSP00000350474 | Olfactory receptor 8D1; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 8 |
| PRIM1 protein network | https://string-db.org/network/9606.ENSP00000350491 | DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type pri [...] |
| AIG1 protein network | https://string-db.org/network/9606.ENSP00000350509 | Androgen-induced gene 1 protein; May play a role in androgen-regulated growth of hair follicles; Belongs to the AIG1 family |
| COPS5 protein network | https://string-db.org/network/9606.ENSP00000350512 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an esse [...] |
| AQPEP protein network | https://string-db.org/network/9606.ENSP00000350541 | Aminopeptidase Q; Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a m [...] |
| SEMA4F protein network | https://string-db.org/network/9606.ENSP00000350547 | Semaphorin-4F; Has growth cone collapse activity against retinal ganglion-cell axons; Semaphorins |
| HMX3 protein network | https://string-db.org/network/9606.ENSP00000350549 | Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core seque [...] |
| RFX4 protein network | https://string-db.org/network/9606.ENSP00000350552 | Transcription factor RFX4; May activate transcription by interacting directly with the X-box; Belongs to the RFX family |
| ZNF441 protein network | https://string-db.org/network/9606.ENSP00000350576 | Zinc finger protein 441; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TLL2 protein network | https://string-db.org/network/9606.ENSP00000350630 | Tolloid-like protein 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral [...] |
| SERTAD1 protein network | https://string-db.org/network/9606.ENSP00000350633 | SERTA domain-containing protein 1; Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 [...] |
| ERI2 protein network | https://string-db.org/network/9606.ENSP00000350651 | ERI1 exoribonuclease family member 2; Belongs to the ERI2 family |
| FAM3B protein network | https://string-db.org/network/9606.ENSP00000350673 | Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family |
| PHF8 protein network | https://string-db.org/network/9606.ENSP00000350676 | Histone lysine demethylase PHF8; Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain developme [...] |
| ELK4 protein network | https://string-db.org/network/9606.ENSP00000350681 | ETS domain-containing protein Elk-4; Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilization of SIRT7 at promoters, followed by d [...] |
| ANKLE2 protein network | https://string-db.org/network/9606.ENSP00000350686 | Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF [...] |
| DDX47 protein network | https://string-db.org/network/9606.ENSP00000350698 | Probable ATP-dependent RNA helicase DDX47; Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors; Belongs to the DEAD box helicase famil [...] |
| C1orf109 protein network | https://string-db.org/network/9606.ENSP00000350704 | Uncharacterized protein C1orf109; May promote cancer cell proliferation by controlling the G1 to S phase transition |
| RAD23B protein network | https://string-db.org/network/9606.ENSP00000350708 | UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultan [...] |
| TUSC1 protein network | https://string-db.org/network/9606.ENSP00000350716 | Tumor suppressor candidate 1 |
| TMCC2 protein network | https://string-db.org/network/9606.ENSP00000350718 | Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE; Transmembra [...] |
| SYNE2 protein network | https://string-db.org/network/9606.ENSP00000350719 | Nesprin-2; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC [...] |
| ST7L protein network | https://string-db.org/network/9606.ENSP00000350734 | Suppression of tumorigenicity 7 like; Belongs to the ST7 family |
| GMFB protein network | https://string-db.org/network/9606.ENSP00000350757 | Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells |
| NR3C2 protein network | https://string-db.org/network/9606.ENSP00000350815 | Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements [...] |
| MPPED2 protein network | https://string-db.org/network/9606.ENSP00000350833 | Metallophosphoesterase MPPED2; Displays low metallophosphoesterase activity (in vitro). May play a role in the development of the nervous system (By similarity); Belongs to the UPF0046 family |
| PAX5 protein network | https://string-db.org/network/9606.ENSP00000350844 | Paired box protein Pax-5; May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specifi [...] |
| HMGN5 protein network | https://string-db.org/network/9606.ENSP00000350848 | High mobility group nucleosome-binding domain-containing protein 5; Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin com [...] |
| C8orf86 protein network | https://string-db.org/network/9606.ENSP00000350856 | Uncharacterized protein C8orf86; Chromosome 8 open reading frame 86 |
| ZNF346 protein network | https://string-db.org/network/9606.ENSP00000350869 | Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity. May bind to specific miRNA hairpins |
| METTL9 protein network | https://string-db.org/network/9606.ENSP00000350874 | Methyltransferase-like protein 9; Methyltransferase like 9 |
| GRAMD1C protein network | https://string-db.org/network/9606.ENSP00000350881 | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding c [...] |
| EPHB4 protein network | https://string-db.org/network/9606.ENSP00000350896 | Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| CTSE protein network | https://string-db.org/network/9606.ENSP00000350911 | Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced [...] |
| GAD1 protein network | https://string-db.org/network/9606.ENSP00000350928 | Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family |
| RABEP2 protein network | https://string-db.org/network/9606.ENSP00000350934 | Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion; Belongs to the rabaptin family |
| TES protein network | https://string-db.org/network/9606.ENSP00000350937 | Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act a [...] |
| GMPPA protein network | https://string-db.org/network/9606.ENSP00000350949 | Mannose-1-phosphate guanyltransferase alpha; May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose |
| WDR37 protein network | https://string-db.org/network/9606.ENSP00000350954 | WD repeat-containing protein 37; WD repeat domain containing |
| TMEM261 protein network | https://string-db.org/network/9606.ENSP00000350961 | Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of [...] |
| RTP2 protein network | https://string-db.org/network/9606.ENSP00000350976 | Receptor-transporting protein 2; Specifically promotes functional cell surface expression of olfactory receptors, but not of other GPCRs; Receptor transporter proteins |
| LCA5L protein network | https://string-db.org/network/9606.ENSP00000351008 | Lebercilin-like protein; LCA5L, lebercilin like |
| NF1 protein network | https://string-db.org/network/9606.ENSP00000351015 | Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity; Armadillo-like helical domain contai [...] |
| TPM1 protein network | https://string-db.org/network/9606.ENSP00000351022 | Tropomyosin alpha-1 chain; Tropomyosin 1; Tropomyosins |
| HSD17B11 protein network | https://string-db.org/network/9606.ENSP00000351035 | Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidog [...] |
| FAM217B protein network | https://string-db.org/network/9606.ENSP00000351040 | Protein FAM217B; Family with sequence similarity 217 member B; Belongs to the FAM217 family |
| ZNF100 protein network | https://string-db.org/network/9606.ENSP00000351042 | Zinc finger protein 100; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZC3HC1 protein network | https://string-db.org/network/9606.ENSP00000351052 | Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of [...] |
| CX3CR1 protein network | https://string-db.org/network/9606.ENSP00000351059 | CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 viru [...] |
| SUSD2 protein network | https://string-db.org/network/9606.ENSP00000351075 | Sushi domain-containing protein 2; May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G [...] |
| WDR55 protein network | https://string-db.org/network/9606.ENSP00000351100 | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity); WD repeat domain containing |
| HNRNPAB protein network | https://string-db.org/network/9606.ENSP00000351108 | Heterogeneous nuclear ribonucleoprotein A/B; Binds single-stranded RNA. Has a high affinity for G- rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing sit [...] |
| FRYL protein network | https://string-db.org/network/9606.ENSP00000351113 | Protein furry homolog-like; Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning se [...] |
| CDHR5 protein network | https://string-db.org/network/9606.ENSP00000351118 | Cadherin-related family member 5; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, [...] |
| RHOT1 protein network | https://string-db.org/network/9606.ENSP00000351132 | Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution; E [...] |
| XAB2 protein network | https://string-db.org/network/9606.ENSP00000351137 | Pre-mRNA-splicing factor SYF1; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family |
| FAM73B protein network | https://string-db.org/network/9606.ENSP00000351138 | Mitoguardin 2; Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regu [...] |
| WTAP protein network | https://string-db.org/network/9606.ENSP00000351141 | Pre-mRNA-splicing regulator WTAP; Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues [...] |
| DCAF4 protein network | https://string-db.org/network/9606.ENSP00000351147 | DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| ATL1 protein network | https://string-db.org/network/9606.ENSP00000351155 | Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...] |
| TXNDC15 protein network | https://string-db.org/network/9606.ENSP00000351157 | Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Involved in ciliogenesis . |
| CNOT3 protein network | https://string-db.org/network/9606.ENSP00000351159 | CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA de [...] |
| DNA2 protein network | https://string-db.org/network/9606.ENSP00000351185 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long [...] |
| ITIH2 protein network | https://string-db.org/network/9606.ENSP00000351190 | Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...] |
| TXLNB protein network | https://string-db.org/network/9606.ENSP00000351206 | Beta-taxilin; Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic; Belongs to the taxilin family |
| KIAA1671 protein network | https://string-db.org/network/9606.ENSP00000351207 | Uncharacterized protein KIAA1671; KIAA1671 |
| EPHA2 protein network | https://string-db.org/network/9606.ENSP00000351209 | Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalin [...] |
| OR6C6 protein network | https://string-db.org/network/9606.ENSP00000351211 | Olfactory receptor 6C6; Odorant receptor; Olfactory receptors, family 6 |
| TOMM7 protein network | https://string-db.org/network/9606.ENSP00000351214 | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex. Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stab [...] |
| ENSG00000228049 protein network | https://string-db.org/network/9606.ENSP00000351218 | DNA-directed RNA polymerase II subunit RPB11-b1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of R [...] |
| VN1R2 protein network | https://string-db.org/network/9606.ENSP00000351244 | Vomeronasal type-1 receptor 2; Putative pheromone receptor; Vomeronasal receptors |
| TRIM33 protein network | https://string-db.org/network/9606.ENSP00000351250 | E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to Pub [...] |
| CASP8 protein network | https://string-db.org/network/9606.ENSP00000351273 | Caspase-8; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it [...] |
| ZNF429 protein network | https://string-db.org/network/9606.ENSP00000351280 | Zinc finger protein 429; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RAD52 protein network | https://string-db.org/network/9606.ENSP00000351284 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-strande [...] |
| COL6A6 protein network | https://string-db.org/network/9606.ENSP00000351310 | Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Collagens |
| PSMB10 protein network | https://string-db.org/network/9606.ENSP00000351314 | Proteasome subunit beta type-10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the le [...] |
| PATE2 protein network | https://string-db.org/network/9606.ENSP00000351325 | Prostate and testis expressed 2; LY6/PLAUR domain containing |
| AKAP4 protein network | https://string-db.org/network/9606.ENSP00000351327 | A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility; A-kinase anchoring proteins |
| ARHGAP19 protein network | https://string-db.org/network/9606.ENSP00000351333 | Rho GTPase-activating protein 19; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state |
| PLXNB1 protein network | https://string-db.org/network/9606.ENSP00000351338 | Plexin-B1; Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration; Belongs to the [...] |
| PTPN5 protein network | https://string-db.org/network/9606.ENSP00000351342 | Tyrosine-protein phosphatase non-receptor type 5; May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family k [...] |
| FAM150A protein network | https://string-db.org/network/9606.ENSP00000351345 | ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly |
| VPS13B protein network | https://string-db.org/network/9606.ENSP00000351346 | Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family |
| PFN3 protein network | https://string-db.org/network/9606.ENSP00000351379 | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatid [...] |
| TMA16 protein network | https://string-db.org/network/9606.ENSP00000351380 | Translation machinery associated 16 homolog |
| ZNF781 protein network | https://string-db.org/network/9606.ENSP00000351391 | Zinc finger protein 781; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SCGB1D4 protein network | https://string-db.org/network/9606.ENSP00000351395 | Secretoglobin family 1D member 4; Seems to be involved in the regulation of chemotactic cell migration and invasion; Belongs to the secretoglobin family. Lipophilin subfamily |
| ARNT protein network | https://string-db.org/network/9606.ENSP00000351407 | Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the n [...] |
| ANKRD17 protein network | https://string-db.org/network/9606.ENSP00000351416 | Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA r [...] |
| C19orf60 protein network | https://string-db.org/network/9606.ENSP00000351422 | Uncharacterized protein C19orf60; Chromosome 19 open reading frame 60 |
| GYPE protein network | https://string-db.org/network/9606.ENSP00000351430 | Glycophorin-E; This protein is a minor sialoglycoprotein in human erythrocyte membranes; Belongs to the glycophorin-A family |
| WDR5 protein network | https://string-db.org/network/9606.ENSP00000351446 | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is invo [...] |
| OR5AC2 protein network | https://string-db.org/network/9606.ENSP00000351466 | Olfactory receptor 5AC2; Odorant receptor; Olfactory receptors, family 5 |
| PASK protein network | https://string-db.org/network/9606.ENSP00000351475 | PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably [...] |
| NAALADL1 protein network | https://string-db.org/network/9606.ENSP00000351484 | N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase-like activity unknown. Has no NAAG hydrolyzing activity. Exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves G [...] |
| MAX protein network | https://string-db.org/network/9606.ENSP00000351490 | Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcrip [...] |
| UBL5 protein network | https://string-db.org/network/9606.ENSP00000351492 | Ubiquitin-like protein 5; Ubiquitin like 5 |
| FCGR2B protein network | https://string-db.org/network/9606.ENSP00000351497 | Low affinity immunoglobulin gamma Fc region receptor II-b; Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector an [...] |
| ENTPD4 protein network | https://string-db.org/network/9606.ENSP00000351520 | Ectonucleoside triphosphate diphosphohydrolase 4; Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity wi [...] |
| HELZ protein network | https://string-db.org/network/9606.ENSP00000351524 | Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo; Belongs to the DNA2/NAM7 helicase [...] |
| ZXDA protein network | https://string-db.org/network/9606.ENSP00000351530 | Zinc finger X-linked protein ZXDA; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Zinc fingers C2H2-type |
| QSOX2 protein network | https://string-db.org/network/9606.ENSP00000351536 | Sulfhydryl oxidase 2; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond [...] |
| ZBTB18 protein network | https://string-db.org/network/9606.ENSP00000351539 | Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myog [...] |
| SMIM7 protein network | https://string-db.org/network/9606.ENSP00000351569 | Small integral membrane protein 7 |
| BDP1 protein network | https://string-db.org/network/9606.ENSP00000351575 | Transcription factor TFIIIB component B'' homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for [...] |
| HIST1H2AI protein network | https://string-db.org/network/9606.ENSP00000351589 | Histone cluster 1 H2A family member i; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| NLGN3 protein network | https://string-db.org/network/9606.ENSP00000351591 | Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may [...] |
| TTC37 protein network | https://string-db.org/network/9606.ENSP00000351596 | Tetratricopeptide repeat protein 37; Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner depe [...] |
| FUT4 protein network | https://string-db.org/network/9606.ENSP00000351602 | Alpha-(1,3)-fucosyltransferase 4; May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens; CD molecules |
| FZD6 protein network | https://string-db.org/network/9606.ENSP00000351605 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| SYN3 protein network | https://string-db.org/network/9606.ENSP00000351614 | Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis; Synapsins |
| PARD3B protein network | https://string-db.org/network/9606.ENSP00000351618 | Partitioning defective 3 homolog B; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions [...] |
| PBLD protein network | https://string-db.org/network/9606.ENSP00000351619 | Phenazine biosynthesis like protein domain containing |
| FAM76B protein network | https://string-db.org/network/9606.ENSP00000351631 | Protein FAM76B; Family with sequence similarity 76 member B; Belongs to the FAM76 family |
| FAM3D protein network | https://string-db.org/network/9606.ENSP00000351632 | Protein FAM3D; Family with sequence similarity 3 member D; Belongs to the FAM3 family |
| BCAS4 protein network | https://string-db.org/network/9606.ENSP00000351642 | Belongs to the cappuccino family |
| GTPBP3 protein network | https://string-db.org/network/9606.ENSP00000351644 | tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs |
| STIP1 protein network | https://string-db.org/network/9606.ENSP00000351646 | Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity); Tetratricopeptide repeat domain c [...] |
| MICAL1 protein network | https://string-db.org/network/9606.ENSP00000351664 | [F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in [...] |
| MANEA protein network | https://string-db.org/network/9606.ENSP00000351669 | Glycoprotein endo-alpha-1,2-mannosidase; Mannosidases endo-alpha |
| CCL20 protein network | https://string-db.org/network/9606.ENSP00000351671 | C-C motif chemokine 20; Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellula [...] |
| CNDP1 protein network | https://string-db.org/network/9606.ENSP00000351682 | Carnosine dipeptidase 1; Belongs to the peptidase M20A family |
| PRDM10 protein network | https://string-db.org/network/9606.ENSP00000351686 | PR domain zinc finger protein 10; May be involved in transcriptional regulation; PR/SET domain family |
| REV3L protein network | https://string-db.org/network/9606.ENSP00000351697 | DNA polymerase zeta catalytic subunit; Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exo [...] |
| GK2 protein network | https://string-db.org/network/9606.ENSP00000351706 | Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family |
| CCER1 protein network | https://string-db.org/network/9606.ENSP00000351727 | Coiled-coil glutamate rich protein 1 |
| TMC2 protein network | https://string-db.org/network/9606.ENSP00000351732 | Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells. Component of the hair cell's mechanotransduction (MET) machinery. Involved in m [...] |
| TMEM126B protein network | https://string-db.org/network/9606.ENSP00000351737 | Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing [...] |
| FAM114A1 protein network | https://string-db.org/network/9606.ENSP00000351740 | Protein NOXP20; May play a role in neuronal cell development; Belongs to the FAM114 family |
| TFEB protein network | https://string-db.org/network/9606.ENSP00000351742 | Transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TF [...] |
| COL20A1 protein network | https://string-db.org/network/9606.ENSP00000351767 | Collagen alpha-1(XX) chain; Probable collagen protein; Collagens |
| FHAD1 protein network | https://string-db.org/network/9606.ENSP00000351770 | Forkhead-associated domain-containing protein 1; Forkhead associated phosphopeptide binding domain 1 |
| VCP protein network | https://string-db.org/network/9606.ENSP00000351777 | Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional end [...] |
| PELI1 protein network | https://string-db.org/network/9606.ENSP00000351789 | E3 ubiquitin-protein ligase pellino homolog 1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathway [...] |
| MYPN protein network | https://string-db.org/network/9606.ENSP00000351790 | Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines; Belongs to the myotilin/palladin family |
| AVPR2 protein network | https://string-db.org/network/9606.ENSP00000351805 | Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption; Belongs [...] |
| ELN protein network | https://string-db.org/network/9606.ENSP00000351807 | Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabili [...] |
| EDC4 protein network | https://string-db.org/network/9606.ENSP00000351811 | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of [...] |
| MARCH5 protein network | https://string-db.org/network/9606.ENSP00000351813 | E3 ubiquitin-protein ligase MARCH5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondri [...] |
| RAB3GAP2 protein network | https://string-db.org/network/9606.ENSP00000351832 | Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are [...] |
| POTEC protein network | https://string-db.org/network/9606.ENSP00000351856 | POTE ankyrin domain family member C |
| ANKRD30B protein network | https://string-db.org/network/9606.ENSP00000351875 | Ankyrin repeat domain-containing protein 30B; Ankyrin repeat domain containing |
| SPANXC protein network | https://string-db.org/network/9606.ENSP00000351884 | Sperm protein associated with the nucleus on the X chromosome C; SPANX family member C; Belongs to the SPAN-X family |
| TGFBR2 protein network | https://string-db.org/network/9606.ENSP00000351905 | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines [...] |
| MAP3K5 protein network | https://string-db.org/network/9606.ENSP00000351908 | Mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...] |
| AP2A1 protein network | https://string-db.org/network/9606.ENSP00000351926 | AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathw [...] |
| KLHL9 protein network | https://string-db.org/network/9606.ENSP00000351933 | Kelch-like protein 9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin [...] |
| C17orf80 protein network | https://string-db.org/network/9606.ENSP00000351937 | Uncharacterized protein C17orf80; Chromosome 17 open reading frame 80 |
| SMARCAD1 protein network | https://string-db.org/network/9606.ENSP00000351947 | ATP-dependent helicase 1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end [...] |
| PDE3A protein network | https://string-db.org/network/9606.ENSP00000351957 | cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important p [...] |
| SFTA2 protein network | https://string-db.org/network/9606.ENSP00000351989 | Surfactant-associated protein 2; Putative surfactant protein |
| NAE1 protein network | https://string-db.org/network/9606.ENSP00000351990 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter l [...] |
| CACNA1G protein network | https://string-db.org/network/9606.ENSP00000352011 | Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| NOL12 protein network | https://string-db.org/network/9606.ENSP00000352021 | Nucleolar protein 12; May bind to 28S rRNA; Belongs to the RRP17 family |
| KCNQ2 protein network | https://string-db.org/network/9606.ENSP00000352035 | Potassium voltage-gated channel subfamily KQT member 2; Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a s [...] |
| NLRC3 protein network | https://string-db.org/network/9606.ENSP00000352039 | NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM1 [...] |
| WWP2 protein network | https://string-db.org/network/9606.ENSP00000352069 | NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...] |
| CD163 protein network | https://string-db.org/network/9606.ENSP00000352071 | Scavenger receptor cysteine-rich type 1 protein M130; Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby prote [...] |
| SPTSSB protein network | https://string-db.org/network/9606.ENSP00000352097 | Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrat [...] |
| GOLGA8A protein network | https://string-db.org/network/9606.ENSP00000352111 | Golgin subfamily A member 8A; May be involved in maintaining Golgi structure |
| HIST1H2AG protein network | https://string-db.org/network/9606.ENSP00000352119 | Histone cluster 1 H2A family member g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| PIK3CG protein network | https://string-db.org/network/9606.ENSP00000352121 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to gener [...] |
| KIRREL protein network | https://string-db.org/network/9606.ENSP00000352138 | Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Signaling protein that needs the presence of TEC kinases to fully trans [...] |
| MAPK10 protein network | https://string-db.org/network/9606.ENSP00000352157 | Mitogen-activated protein kinase 10; Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellu [...] |
| ELAVL3 protein network | https://string-db.org/network/9606.ENSP00000352162 | ELAV-like protein 3; Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and [...] |
| LYPD2 protein network | https://string-db.org/network/9606.ENSP00000352163 | LY6/PLAUR domain containing 2 |
| SLC25A29 protein network | https://string-db.org/network/9606.ENSP00000352167 | Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Can restore ornithine transport in ce [...] |
| VSIG10 protein network | https://string-db.org/network/9606.ENSP00000352172 | V-set and immunoglobulin domain containing 10 |
| PLAC1 protein network | https://string-db.org/network/9606.ENSP00000352173 | Placenta-specific protein 1; May play a role in placental development; Belongs to the PLAC1 family |
| FAM86C1 protein network | https://string-db.org/network/9606.ENSP00000352182 | Protein FAM86C1; Family with sequence similarity 86 member C1 |
| PHF2 protein network | https://string-db.org/network/9606.ENSP00000352185 | Lysine-specific demethylase PHF2; Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PK [...] |
| MYOF protein network | https://string-db.org/network/9606.ENSP00000352208 | Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress [...] |
| SLC2A10 protein network | https://string-db.org/network/9606.ENSP00000352216 | Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter; Solute carriers |
| ZNF705A protein network | https://string-db.org/network/9606.ENSP00000352233 | Zinc finger protein 705A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ANXA10 protein network | https://string-db.org/network/9606.ENSP00000352248 | Annexin A10; Annexins |
| HIST1H3J protein network | https://string-db.org/network/9606.ENSP00000352252 | Histone cluster 1 H3 family member j; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| XRCC6 protein network | https://string-db.org/network/9606.ENSP00000352257 | X-ray repair cross-complementing protein 6; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork- [...] |
| CD2AP protein network | https://string-db.org/network/9606.ENSP00000352264 | CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regu [...] |
| TPGS1 protein network | https://string-db.org/network/9606.ENSP00000352265 | Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum (By similarity) |
| AADACL3 protein network | https://string-db.org/network/9606.ENSP00000352268 | Arylacetamide deacetylase-like 3; Arylacetamide deacetylase family |
| XRCC2 protein network | https://string-db.org/network/9606.ENSP00000352271 | DNA repair protein XRCC2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of [...] |
| MYOZ1 protein network | https://string-db.org/network/9606.ENSP00000352272 | Myozenin-1; Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin [...] |
| KLHDC1 protein network | https://string-db.org/network/9606.ENSP00000352282 | Kelch domain containing 1 |
| TMEM139 protein network | https://string-db.org/network/9606.ENSP00000352284 | Transmembrane protein 139; May be involved in cellular trafficking of proteins such as SLC4A1 |
| CGB2 protein network | https://string-db.org/network/9606.ENSP00000352295 | Chorionic gonadotropin beta subunit 2 |
| SLFNL1 protein network | https://string-db.org/network/9606.ENSP00000352299 | Schlafen-like protein 1; Schlafen family |
| OR51A7 protein network | https://string-db.org/network/9606.ENSP00000352305 | Olfactory receptor 51A7; Odorant receptor; Olfactory receptors, family 51 |
| KLHL14 protein network | https://string-db.org/network/9606.ENSP00000352314 | Kelch-like protein 14; Kelch like family member 14; BTB domain containing |
| TRPV6 protein network | https://string-db.org/network/9606.ENSP00000352358 | Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca [...] |
| NUP214 protein network | https://string-db.org/network/9606.ENSP00000352400 | Nuclear pore complex protein Nup214; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex; Nucleoporins |
| RPE protein network | https://string-db.org/network/9606.ENSP00000352401 | Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family |
| BABAM1 protein network | https://string-db.org/network/9606.ENSP00000352408 | BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to t [...] |
| TMC3 protein network | https://string-db.org/network/9606.ENSP00000352413 | Transmembrane channel-like protein 3; Probable ion channel; Transmembrane channel likes |
| FGF17 protein network | https://string-db.org/network/9606.ENSP00000352414 | Fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for norm [...] |
| LDLRAD4 protein network | https://string-db.org/network/9606.ENSP00000352420 | Low-density lipoprotein receptor class A domain-containing protein 4; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiat [...] |
| TIAF1 protein network | https://string-db.org/network/9606.ENSP00000352424 | TGFB1-induced anti-apoptotic factor 1; Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alph [...] |
| RGR protein network | https://string-db.org/network/9606.ENSP00000352427 | RPE-retinal G protein-coupled receptor; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like [...] |
| PCBP2 protein network | https://string-db.org/network/9606.ENSP00000352438 | Poly(rC)-binding protein 2; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates [...] |
| ZNF33B protein network | https://string-db.org/network/9606.ENSP00000352444 | Zinc finger protein 33B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| C1orf116 protein network | https://string-db.org/network/9606.ENSP00000352447 | Specifically androgen-regulated gene protein; Putative androgen-specific receptor; Belongs to the SARG family |
| MFAP5 protein network | https://string-db.org/network/9606.ENSP00000352455 | Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel int [...] |
| PLGLB2 protein network | https://string-db.org/network/9606.ENSP00000352458 | Plasminogen-like protein B; May bind noncovalently to lysine binding sites present in the kringle structures of plasminogen. This may interfere with the binding of fibrin or alpha-2-antiplasmin t [...] |
| TCF20 protein network | https://string-db.org/network/9606.ENSP00000352463 | Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional a [...] |
| TECPR2 protein network | https://string-db.org/network/9606.ENSP00000352510 | Tectonin beta-propeller repeat-containing protein 2; Probably plays a role as positive regulator of autophagy; Belongs to the WD repeat KIAA0329 family |
| MPZL1 protein network | https://string-db.org/network/9606.ENSP00000352513 | Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP [...] |
| DNMT1 protein network | https://string-db.org/network/9606.ENSP00000352516 | DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern i [...] |
| ATP6V1H protein network | https://string-db.org/network/9606.ENSP00000352522 | V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar [...] |
| KCNK5 protein network | https://string-db.org/network/9606.ENSP00000352527 | Potassium channel subfamily K member 5; pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations; Potassium tw [...] |
| GTF3C2 protein network | https://string-db.org/network/9606.ENSP00000352536 | General transcription factor 3C polypeptide 2; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required fo [...] |
| EMP2 protein network | https://string-db.org/network/9606.ENSP00000352540 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell mi [...] |
| CPLX2 protein network | https://string-db.org/network/9606.ENSP00000352544 | Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of [...] |
| CALCR protein network | https://string-db.org/network/9606.ENSP00000352561 | Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to th [...] |
| HAND2 protein network | https://string-db.org/network/9606.ENSP00000352565 | Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for v [...] |
| PCNT protein network | https://string-db.org/network/9606.ENSP00000352572 | Pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, togeth [...] |
| AKR1B10 protein network | https://string-db.org/network/9606.ENSP00000352584 | Aldo-keto reductase family 1 member B10; Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be respo [...] |
| LRP10 protein network | https://string-db.org/network/9606.ENSP00000352601 | Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake [...] |
| AP4M1 protein network | https://string-db.org/network/9606.ENSP00000352603 | AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They co [...] |
| OR2T3 protein network | https://string-db.org/network/9606.ENSP00000352604 | Olfactory receptor 2T3; Odorant receptor; Olfactory receptors, family 2 |
| HAPLN3 protein network | https://string-db.org/network/9606.ENSP00000352606 | Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding; V-set domain containing |
| RYR1 protein network | https://string-db.org/network/9606.ENSP00000352608 | Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction followin [...] |
| ZSWIM5 protein network | https://string-db.org/network/9606.ENSP00000352614 | Zinc finger SWIM-type containing 5 |
| OR6K2 protein network | https://string-db.org/network/9606.ENSP00000352626 | Olfactory receptor 6K2; Odorant receptor; Olfactory receptors, family 6 |
| HIST1H2AM protein network | https://string-db.org/network/9606.ENSP00000352627 | Histone cluster 1 H2A family member m; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| CELA2A protein network | https://string-db.org/network/9606.ENSP00000352639 | Chymotrypsin-like elastase family member 2A; Acts upon elastin |
| LRRC61 protein network | https://string-db.org/network/9606.ENSP00000352642 | Leucine-rich repeat-containing protein 61; Leucine rich repeat containing 61 |
| TYW1 protein network | https://string-db.org/network/9606.ENSP00000352645 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found [...] |
| PGLYRP4 protein network | https://string-db.org/network/9606.ENSP00000352672 | Peptidoglycan recognition protein 4; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram- [...] |
| ELF3 protein network | https://string-db.org/network/9606.ENSP00000352673 | ETS-related transcription factor Elf-3; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with [...] |
| ZRANB1 protein network | https://string-db.org/network/9606.ENSP00000352676 | Ubiquitin thioesterase ZRANB1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29' [...] |
| SUPV3L1 protein network | https://string-db.org/network/9606.ENSP00000352678 | ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang dou [...] |
| HIBCH protein network | https://string-db.org/network/9606.ENSP00000352706 | 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrog [...] |
| OR2M2 protein network | https://string-db.org/network/9606.ENSP00000352710 | Olfactory receptor 2M2; Odorant receptor; Olfactory receptors, family 2 |
| OR13G1 protein network | https://string-db.org/network/9606.ENSP00000352717 | Olfactory receptor 13G1; Odorant receptor; Olfactory receptors, family 13 |
| G3BP2 protein network | https://string-db.org/network/9606.ENSP00000352738 | Ras GTPase-activating protein-binding protein 2; Probable scaffold protein that may be involved in mRNA transport; RNA binding motif containing |
| SLC39A14 protein network | https://string-db.org/network/9606.ENSP00000352779 | Zinc transporter ZIP14; Broad-scope metal ion transporter with a preference for zinc uptake. Also mediates cellular uptake of nontransferrin-bound iron; Belongs to the ZIP transporter (TC 2.A.5) [...] |
| DSG4 protein network | https://string-db.org/network/9606.ENSP00000352785 | Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition fr [...] |
| ZDHHC14 protein network | https://string-db.org/network/9606.ENSP00000352821 | Probable palmitoyltransferase ZDHHC14; Zinc finger DHHC-type containing 14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily |
| PTPN22 protein network | https://string-db.org/network/9606.ENSP00000352833 | Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TC [...] |
| MYO1C protein network | https://string-db.org/network/9606.ENSP00000352834 | Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| ZNF675 protein network | https://string-db.org/network/9606.ENSP00000352836 | Zinc finger protein 675; May be involved in transcriptional regulation. May play a role during osteoclast differentiation by modulating TRAF6 signaling activity; Zinc fingers C2H2-type |
| ZNF808 protein network | https://string-db.org/network/9606.ENSP00000352846 | Zinc finger protein 808; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SIRPB2 protein network | https://string-db.org/network/9606.ENSP00000352849 | Signal-regulatory protein beta-2; Signal regulatory protein beta 2 |
| PLXNA4 protein network | https://string-db.org/network/9606.ENSP00000352882 | Plexin-A4; Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Cla [...] |
| RXRG protein network | https://string-db.org/network/9606.ENSP00000352900 | Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retin [...] |
| NT5C1B protein network | https://string-db.org/network/9606.ENSP00000352904 | Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity); 5'-nucleotidases |
| TRRAP protein network | https://string-db.org/network/9606.ENSP00000352925 | Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a sp [...] |
| TEAD4 protein network | https://string-db.org/network/9606.ENSP00000352926 | Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...] |
| MTCL1 protein network | https://string-db.org/network/9606.ENSP00000352927 | Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and ma [...] |
| DDA1 protein network | https://string-db.org/network/9606.ENSP00000352928 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform f [...] |
| SPINK5 protein network | https://string-db.org/network/9606.ENSP00000352936 | Serine protease inhibitor Kazal-type 5; Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity an [...] |
| KCTD18 protein network | https://string-db.org/network/9606.ENSP00000352941 | BTB/POZ domain-containing protein KCTD18; Potassium channel tetramerization domain containing 18 |
| RBM23 protein network | https://string-db.org/network/9606.ENSP00000352956 | Probable RNA-binding protein 23; Probable RNA-binding protein. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family |
| LPPR3 protein network | https://string-db.org/network/9606.ENSP00000352962 | Lipid phosphate phosphatase-related protein type 3 |
| AMZ2 protein network | https://string-db.org/network/9606.ENSP00000352976 | Archaemetzincin-2; Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze either neurogranin or angiotensin-2; Belongs to the peptidase M54 family |
| ARHGEF18 protein network | https://string-db.org/network/9606.ENSP00000352995 | Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. Its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, [...] |
| SULF2 protein network | https://string-db.org/network/9606.ENSP00000353007 | Extracellular sulfatase Sulf-2; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specifi [...] |
| ATG2B protein network | https://string-db.org/network/9606.ENSP00000353010 | Autophagy-related protein 2 homolog B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Autophagy related |
| CLEC14A protein network | https://string-db.org/network/9606.ENSP00000353013 | C-type lectin domain containing 14A |
| FAM3C protein network | https://string-db.org/network/9606.ENSP00000353025 | Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition |
| PTPRF protein network | https://string-db.org/network/9606.ENSP00000353030 | Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its a [...] |
| P2RX4 protein network | https://string-db.org/network/9606.ENSP00000353032 | P2X purinoceptor 4; Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin; Purinergic receptors P2X |
| OR2L3 protein network | https://string-db.org/network/9606.ENSP00000353044 | Olfactory receptor 2L3; Odorant receptor; Olfactory receptors, family 2 |
| CCT8L2 protein network | https://string-db.org/network/9606.ENSP00000353048 | T-complex protein 1 subunit theta-like 2; Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis; Belongs to the TCP-1 chaperonin family |
| ZNF517 protein network | https://string-db.org/network/9606.ENSP00000353058 | Zinc finger protein 517; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ATP2A3 protein network | https://string-db.org/network/9606.ENSP00000353072 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytoso [...] |
| SDF4 protein network | https://string-db.org/network/9606.ENSP00000353094 | 45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family |
| MCMBP protein network | https://string-db.org/network/9606.ENSP00000353098 | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes [...] |
| HLA-DRB1 protein network | https://string-db.org/network/9606.ENSP00000353099 | HLA class II histocompatibility antigen, DRB1-15 beta chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell s [...] |
| DHDDS protein network | https://string-db.org/network/9606.ENSP00000353104 | Dehydrodolichyl diphosphate synthase complex subunit DHDDS; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) [...] |
| AHNAK2 protein network | https://string-db.org/network/9606.ENSP00000353114 | AHNAK nucleoprotein 2; PDZ domain containing |
| DCAF12L2 protein network | https://string-db.org/network/9606.ENSP00000353128 | DDB1- and CUL4-associated factor 12-like protein 2; DDB1 and CUL4 associated factor 12 like 2; Belongs to the WD repeat DCAF12 family |
| KCTD8 protein network | https://string-db.org/network/9606.ENSP00000353129 | BTB/POZ domain-containing protein KCTD8; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...] |
| DMBX1 protein network | https://string-db.org/network/9606.ENSP00000353132 | Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. May repress OTX2-mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3' [...] |
| GAL3ST4 protein network | https://string-db.org/network/9606.ENSP00000353142 | Galactose-3-O-sulfotransferase 4; Catalyzes the transfer of sulfate to beta-1,3-linked galactose residues in O-linked glycoproteins. Good substrates include asialofetuin, Gal-beta-1,3-GalNAc and [...] |
| HOXA4 protein network | https://string-db.org/network/9606.ENSP00000353151 | Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| TPK1 protein network | https://string-db.org/network/9606.ENSP00000353165 | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate |
| PYY protein network | https://string-db.org/network/9606.ENSP00000353198 | Peptide YY; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility; Endogenous ligands |
| LCE1B protein network | https://string-db.org/network/9606.ENSP00000353203 | Late cornified envelope protein 1B; Precursors of the cornified envelope of the stratum corneum |
| ARL9 protein network | https://string-db.org/network/9606.ENSP00000353210 | ADP-ribosylation factor-like protein 9; ADP ribosylation factor like GTPase 9; ARF GTPase family |
| TFRC protein network | https://string-db.org/network/9606.ENSP00000353224 | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads [...] |
| SPN protein network | https://string-db.org/network/9606.ENSP00000353238 | Leukosialin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate liga [...] |
| C17orf97 protein network | https://string-db.org/network/9606.ENSP00000353245 | Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation |
| MAK16 protein network | https://string-db.org/network/9606.ENSP00000353246 | Protein MAK16 homolog; RNA binding motif containing |
| AGBL5 protein network | https://string-db.org/network/9606.ENSP00000353249 | Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains g [...] |
| CD300A protein network | https://string-db.org/network/9606.ENSP00000353259 | CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. [...] |
| ERGIC2 protein network | https://string-db.org/network/9606.ENSP00000353270 | Endoplasmic reticulum-Golgi intermediate compartment protein 2; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family |
| SCNN1A protein network | https://string-db.org/network/9606.ENSP00000353292 | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...] |
| CBWD3 protein network | https://string-db.org/network/9606.ENSP00000353295 | COBW domain containing 3 |
| KIRREL2 protein network | https://string-db.org/network/9606.ENSP00000353331 | Kin of IRRE-like protein 2; Kirre like nephrin family adhesion molecule 2; C2-set domain containing |
| RTEL1 protein network | https://string-db.org/network/9606.ENSP00000353332 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase [...] |
| OR52M1 protein network | https://string-db.org/network/9606.ENSP00000353343 | Olfactory receptor 52M1; Odorant receptor; Olfactory receptors, family 52 |
| ETS2 protein network | https://string-db.org/network/9606.ENSP00000353344 | Protein C-ets-2; Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription |
| LHFPL5 protein network | https://string-db.org/network/9606.ENSP00000353346 | LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Reg [...] |
| CACNA1A protein network | https://string-db.org/network/9606.ENSP00000353362 | Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of [...] |
| MAP4 protein network | https://string-db.org/network/9606.ENSP00000353375 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly |
| CCDC102B protein network | https://string-db.org/network/9606.ENSP00000353377 | Coiled-coil domain containing 102B |
| MAGEA4 protein network | https://string-db.org/network/9606.ENSP00000353379 | Melanoma-associated antigen 4; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family |
| F8 protein network | https://string-db.org/network/9606.ENSP00000353393 | Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa; Belongs to the mult [...] |
| CUX1 protein network | https://string-db.org/network/9606.ENSP00000353401 | Homeobox protein cut-like 1; Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing C [...] |
| MSN protein network | https://string-db.org/network/9606.ENSP00000353408 | Moesin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage. Plays a role in regulating the pr [...] |
| ATP2B2 protein network | https://string-db.org/network/9606.ENSP00000353414 | Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting |
| VPS13A protein network | https://string-db.org/network/9606.ENSP00000353422 | Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane |
| RAB5B protein network | https://string-db.org/network/9606.ENSP00000353444 | Ras-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family |
| MYLK protein network | https://string-db.org/network/9606.ENSP00000353452 | Myosin light chain kinase, smooth muscle; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also reg [...] |
| BAZ1A protein network | https://string-db.org/network/9606.ENSP00000353458 | Bromodomain adjacent to zinc finger domain protein 1A; Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate eve [...] |
| CASS4 protein network | https://string-db.org/network/9606.ENSP00000353462 | Cas scaffolding protein family member 4; Docking protein that plays a role in tyrosine kinase- based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adh [...] |
| GATAD2A protein network | https://string-db.org/network/9606.ENSP00000353463 | Transcriptional repressor p66-alpha; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B; GATA zinc finger domain containing |
| C20orf96 protein network | https://string-db.org/network/9606.ENSP00000353470 | Uncharacterized protein C20orf96; Chromosome 20 open reading frame 96 |
| CLDN7 protein network | https://string-db.org/network/9606.ENSP00000353475 | Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family |
| ZNF460 protein network | https://string-db.org/network/9606.ENSP00000353491 | Zinc finger protein 460; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LZTS3 protein network | https://string-db.org/network/9606.ENSP00000353496 | Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belong [...] |
| MAP2 protein network | https://string-db.org/network/9606.ENSP00000353508 | Microtubule-associated protein 2; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubule [...] |
| PARP9 protein network | https://string-db.org/network/9606.ENSP00000353512 | Poly [ADP-ribose] polymerase 9; ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antivira [...] |
| OR2W3 protein network | https://string-db.org/network/9606.ENSP00000353516 | Olfactory receptor 2W3; Odorant receptor; Olfactory receptors, family 2 |
| ANKS1A protein network | https://string-db.org/network/9606.ENSP00000353518 | Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction [...] |
| OR5B21 protein network | https://string-db.org/network/9606.ENSP00000353537 | Olfactory receptor 5B21; Odorant receptor; Olfactory receptors, family 5 |
| LRRCC1 protein network | https://string-db.org/network/9606.ENSP00000353538 | Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis |
| CDC16 protein network | https://string-db.org/network/9606.ENSP00000353549 | Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| SLC35F1 protein network | https://string-db.org/network/9606.ENSP00000353557 | Solute carrier family 35 member F1; Putative solute transporter |
| EIF2B3 protein network | https://string-db.org/network/9606.ENSP00000353575 | Translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family |
| NRP2 protein network | https://string-db.org/network/9606.ENSP00000353582 | Neuropilin-2; High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF |
| MYH10 protein network | https://string-db.org/network/9606.ENSP00000353590 | Myosin-10; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I coll [...] |
| SULT1A4 protein network | https://string-db.org/network/9606.ENSP00000353600 | Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4; Sulfotransferase family 1A member 4; Sulfotransferases, cytosolic |
| DSC3 protein network | https://string-db.org/network/9606.ENSP00000353608 | Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal [...] |
| CLPSL2 protein network | https://string-db.org/network/9606.ENSP00000353639 | Colipase-like protein 2; Colipase like 2 |
| PLEKHG4 protein network | https://string-db.org/network/9606.ENSP00000353646 | Puratrophin-1; Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi; Pleckstrin homology domain containing |
| FABP12 protein network | https://string-db.org/network/9606.ENSP00000353650 | Fatty acid-binding protein 12; May play a role in lipid transport; Fatty acid binding protein family |
| ZNF528 protein network | https://string-db.org/network/9606.ENSP00000353652 | Zinc finger protein 528; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| COL4A2 protein network | https://string-db.org/network/9606.ENSP00000353654 | Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| SPOCD1 protein network | https://string-db.org/network/9606.ENSP00000353670 | Protein phosphatase 1 regulatory subunits |
| DPP3 protein network | https://string-db.org/network/9606.ENSP00000353701 | Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro); Belongs to the pepti [...] |
| CCDC144A protein network | https://string-db.org/network/9606.ENSP00000353717 | Coiled-coil domain containing 144A |
| CES1 protein network | https://string-db.org/network/9606.ENSP00000353720 | Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity [...] |
| DPP4 protein network | https://string-db.org/network/9606.ENSP00000353731 | Dipeptidyl peptidase 4; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-c [...] |
| CLIP3 protein network | https://string-db.org/network/9606.ENSP00000353732 | CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and p [...] |
| PLAGL1 protein network | https://string-db.org/network/9606.ENSP00000353734 | Zinc finger protein PLAGL1; Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide; Belongs to the [...] |
| TOPORS protein network | https://string-db.org/network/9606.ENSP00000353735 | E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apopto [...] |
| PCMTD1 protein network | https://string-db.org/network/9606.ENSP00000353739 | protein-L-isoaspartate O-methyltransferase domain containing 1; Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family |
| ETF1 protein network | https://string-db.org/network/9606.ENSP00000353741 | Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the tran [...] |
| KRTAP26-1 protein network | https://string-db.org/network/9606.ENSP00000353742 | Keratin-associated protein 26-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| MMP17 protein network | https://string-db.org/network/9606.ENSP00000353767 | Matrix metalloproteinase-17; Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth f [...] |
| SCAF1 protein network | https://string-db.org/network/9606.ENSP00000353769 | Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing |
| RRM2 protein network | https://string-db.org/network/9606.ENSP00000353770 | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. In [...] |
| TPPP protein network | https://string-db.org/network/9606.ENSP00000353785 | Tubulin polymerization-promoting protein; May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining [...] |
| SLC6A9 protein network | https://string-db.org/network/9606.ENSP00000353791 | Sodium- and chloride-dependent glycine transporter 1; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of [...] |
| WDHD1 protein network | https://string-db.org/network/9606.ENSP00000353793 | WD repeat and HMG-box DNA-binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA [...] |
| FBXL22 protein network | https://string-db.org/network/9606.ENSP00000353794 | F-box and leucine-rich protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-act [...] |
| ANKRD53 protein network | https://string-db.org/network/9606.ENSP00000353796 | Ankyrin repeat domain-containing protein 53; Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization; Ankyr [...] |
| CYP2D6 protein network | https://string-db.org/network/9606.ENSP00000353820 | Cytochrome P450 2D6; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor ant [...] |
| PIM3 protein network | https://string-db.org/network/9606.ENSP00000353824 | Serine/threonine-protein kinase pim-3; Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigene [...] |
| LONP1 protein network | https://string-db.org/network/9606.ENSP00000353826 | Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-l [...] |
| ITGB1BP1 protein network | https://string-db.org/network/9606.ENSP00000353850 | Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alph [...] |
| C15orf39 protein network | https://string-db.org/network/9606.ENSP00000353854 | Uncharacterized protein C15orf39; Chromosome 15 open reading frame 39 |
| ZNF148 protein network | https://string-db.org/network/9606.ENSP00000353863 | Zinc finger protein 148; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhanc [...] |
| PAK3 protein network | https://string-db.org/network/9606.ENSP00000353864 | Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cy [...] |
| PCED1A protein network | https://string-db.org/network/9606.ENSP00000353868 | PC-esterase domain containing 1A; Belongs to the PC-esterase family |
| TLR9 protein network | https://string-db.org/network/9606.ENSP00000353874 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific t [...] |
| LGALS14 protein network | https://string-db.org/network/9606.ENSP00000353893 | Placental protein 13-like; Binds beta-galactoside and lactose. Strong inducer of T- cell apoptosis; Galectins |
| CSNK1G3 protein network | https://string-db.org/network/9606.ENSP00000353904 | Casein kinase I isoform gamma-3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It c [...] |
| FUT8 protein network | https://string-db.org/network/9606.ENSP00000353910 | Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans; Belongs to the glycosyltransferase 23 f [...] |
| HTR4 protein network | https://string-db.org/network/9606.ENSP00000353915 | 5-hydroxytryptamine receptor 4; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mito [...] |
| ADARB1 protein network | https://string-db.org/network/9606.ENSP00000353920 | Double-stranded RNA-specific editase 1; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene express [...] |
| CCDC135 protein network | https://string-db.org/network/9606.ENSP00000353942 | Dynein regulatory complex subunit 7; Key component of the nexin-dynein regulatory complex (N- DRC), essential for N-DRC integrity. Involved in the regulation of flagellar motility; Belongs to the [...] |
| OR10A3 protein network | https://string-db.org/network/9606.ENSP00000353988 | Olfactory receptor 10A3; Odorant receptor; Olfactory receptors, family 10 |
| KRTAP12-2 protein network | https://string-db.org/network/9606.ENSP00000354001 | Keratin-associated protein 12-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| GYPA protein network | https://string-db.org/network/9606.ENSP00000354003 | Glycophorin-A; Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group recep [...] |
| TRPM6 protein network | https://string-db.org/network/9606.ENSP00000354006 | Transient receptor potential cation channel subfamily M member 6; Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial [...] |
| GJA9 protein network | https://string-db.org/network/9606.ENSP00000354020 | Gap junction alpha-9 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| BSCL2 protein network | https://string-db.org/network/9606.ENSP00000354032 | Seipin; Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lip [...] |
| GTPBP4 protein network | https://string-db.org/network/9606.ENSP00000354040 | Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily |
| GLT8D2 protein network | https://string-db.org/network/9606.ENSP00000354053 | Glycosyltransferase 8 domain containing 2 |
| SCYL2 protein network | https://string-db.org/network/9606.ENSP00000354061 | SCY1-like protein 2; Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein [...] |
| SCUBE1 protein network | https://string-db.org/network/9606.ENSP00000354080 | Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology |
| ANKHD1 protein network | https://string-db.org/network/9606.ENSP00000354085 | Ankyrin repeat and KH domain-containing protein 1; May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapop [...] |
| MRPL37 protein network | https://string-db.org/network/9606.ENSP00000354086 | Mitochondrial ribosomal protein L37; Belongs to the mitochondrion-specific ribosomal protein mL37 family |
| SIGLEC14 protein network | https://string-db.org/network/9606.ENSP00000354090 | Sialic acid-binding Ig-like lectin 14; Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors; Belongs to the immunoglobulin superfamily. SIGLEC ( [...] |
| RGS22 protein network | https://string-db.org/network/9606.ENSP00000354109 | Regulator of G-protein signaling 22; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form; Regulators [...] |
| DNAJC5 protein network | https://string-db.org/network/9606.ENSP00000354111 | DnaJ homolog subfamily C member 5; Acts as a general chaperone in regulated exocytosis (By similarity). Acts as a co-chaperone for the SNARE protein SNAP-25 (By similarity). Involved in the calci [...] |
| EIF3B protein network | https://string-db.org/network/9606.ENSP00000354125 | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...] |
| MTHFSD protein network | https://string-db.org/network/9606.ENSP00000354152 | Methenyltetrahydrofolate synthase domain-containing protein; Methenyltetrahydrofolate synthetase domain containing; RNA binding motif containing |
| FAM110A protein network | https://string-db.org/network/9606.ENSP00000354163 | Protein FAM110A; Family with sequence similarity 110 member A; Belongs to the FAM110 family |
| UBE2Z protein network | https://string-db.org/network/9606.ENSP00000354201 | Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involv [...] |
| TOMM20L protein network | https://string-db.org/network/9606.ENSP00000354204 | TOMM20-like protein 1; Translocase of outer mitochondrial membrane 20 like |
| ZNF219 protein network | https://string-db.org/network/9606.ENSP00000354206 | Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3'. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulat [...] |
| NTRK3 protein network | https://string-db.org/network/9606.ENSP00000354207 | NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activ [...] |
| HS3ST3B1 protein network | https://string-db.org/network/9606.ENSP00000354213 | Heparan sulfate glucosamine 3-O-sulfotransferase 3B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N- unsubstituted glucosa [...] |
| MPC1 protein network | https://string-db.org/network/9606.ENSP00000354223 | Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria; Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family |
| C11orf80 protein network | https://string-db.org/network/9606.ENSP00000354227 | Type 2 DNA topoisomerase 6 subunit B-like; Isoform 3: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms [...] |
| ENPP1 protein network | https://string-db.org/network/9606.ENSP00000354238 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; By generating PPi, plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcific [...] |
| NCKAP1 protein network | https://string-db.org/network/9606.ENSP00000354251 | Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Act [...] |
| CPZ protein network | https://string-db.org/network/9606.ENSP00000354255 | Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during proh [...] |
| PRSS3 protein network | https://string-db.org/network/9606.ENSP00000354280 | Trypsin-3; Digestive protease specialized for the degradation of trypsin inhibitors. In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family |
| CTRB1 protein network | https://string-db.org/network/9606.ENSP00000354294 | Chymotrypsinogen B1; Belongs to the peptidase S1 family |
| ZSCAN12 protein network | https://string-db.org/network/9606.ENSP00000354305 | Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation; SCAN domain containing |
| MPEG1 protein network | https://string-db.org/network/9606.ENSP00000354335 | Macrophage-expressed gene 1 protein; Macrophage expressed 1 |
| UBA3 protein network | https://string-db.org/network/9606.ENSP00000354340 | NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter lin [...] |
| MATR3 protein network | https://string-db.org/network/9606.ENSP00000354346 | Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a ro [...] |
| LAMC3 protein network | https://string-db.org/network/9606.ENSP00000354360 | Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| RFWD3 protein network | https://string-db.org/network/9606.ENSP00000354361 | E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA- mediated DNA damage [...] |
| RAB25 protein network | https://string-db.org/network/9606.ENSP00000354376 | Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of [...] |
| ZNF37A protein network | https://string-db.org/network/9606.ENSP00000354377 | Zinc finger protein 37A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NMRK1 protein network | https://string-db.org/network/9606.ENSP00000354387 | Nicotinamide riboside kinase 1; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucl [...] |
| STAT1 protein network | https://string-db.org/network/9606.ENSP00000354394 | Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other c [...] |
| CYTH1 protein network | https://string-db.org/network/9606.ENSP00000354398 | Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By sim [...] |
| ZNF627 protein network | https://string-db.org/network/9606.ENSP00000354414 | Zinc finger protein 627; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MICU1 protein network | https://string-db.org/network/9606.ENSP00000354415 | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodi [...] |
| CCL28 protein network | https://string-db.org/network/9606.ENSP00000354416 | C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner; Chemokine ligands |
| JADE2 protein network | https://string-db.org/network/9606.ENSP00000354425 | E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk [...] |
| ANKRD30A protein network | https://string-db.org/network/9606.ENSP00000354432 | Ankyrin repeat domain-containing protein 30A; Ankyrin repeat domain containing |
| IQGAP3 protein network | https://string-db.org/network/9606.ENSP00000354451 | Ras GTPase-activating-like protein IQGAP3; IQ motif containing GTPase activating protein 3 |
| ZFP2 protein network | https://string-db.org/network/9606.ENSP00000354453 | Zinc finger protein 2 homolog; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance; Zinc fingers C2H2-type |
| C8A protein network | https://string-db.org/network/9606.ENSP00000354458 | Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of t [...] |
| FAM109A protein network | https://string-db.org/network/9606.ENSP00000354461 | Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane; Pleckstrin homology domain contai [...] |
| CYB5R3 protein network | https://string-db.org/network/9606.ENSP00000354468 | NADH-cytochrome b5 reductase 3; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction |
| SREBF2 protein network | https://string-db.org/network/9606.ENSP00000354476 | Sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser [...] |
| DLX1 protein network | https://string-db.org/network/9606.ENSP00000354478 | Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the tra [...] |
| BRINP2 protein network | https://string-db.org/network/9606.ENSP00000354481 | BMP/retinoic acid-inducible neural-specific protein 2; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition |
| DUSP27 protein network | https://string-db.org/network/9606.ENSP00000354483 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation |
| ZEB1 protein network | https://string-db.org/network/9606.ENSP00000354487 | Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending [...] |
| TNNI1 protein network | https://string-db.org/network/9606.ENSP00000354488 | Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase act [...] |
| ATP1A2 protein network | https://string-db.org/network/9606.ENSP00000354490 | Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...] |
| FAN1 protein network | https://string-db.org/network/9606.ENSP00000354497 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair [...] |
| PHLDB1 protein network | https://string-db.org/network/9606.ENSP00000354498 | Pleckstrin homology like domain family B member 1 |
| MT-CO1 protein network | https://string-db.org/network/9606.ENSP00000354499 | Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzym [...] |
| ZNF277 protein network | https://string-db.org/network/9606.ENSP00000354501 | Zinc finger protein 277; May be involved in transcriptional regulation |
| ASTN2 protein network | https://string-db.org/network/9606.ENSP00000354504 | Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular tra [...] |
| COMT protein network | https://string-db.org/network/9606.ENSP00000354511 | Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certa [...] |
| ZNF830 protein network | https://string-db.org/network/9606.ENSP00000354518 | Zinc finger protein 830; Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents [...] |
| INPP5F protein network | https://string-db.org/network/9606.ENSP00000354519 | Phosphatidylinositide phosphatase SAC2; Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-b [...] |
| TOP1 protein network | https://string-db.org/network/9606.ENSP00000354522 | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA dup [...] |
| MRPL24 protein network | https://string-db.org/network/9606.ENSP00000354525 | Mitochondrial ribosomal protein L24; Belongs to the universal ribosomal protein uL24 family |
| PNP protein network | https://string-db.org/network/9606.ENSP00000354532 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formati [...] |
| ASTN1 protein network | https://string-db.org/network/9606.ENSP00000354536 | Astrotactin-1; Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migr [...] |
| TSC22D2 protein network | https://string-db.org/network/9606.ENSP00000354543 | TSC22 domain family member 2 |
| C1orf85 protein network | https://string-db.org/network/9606.ENSP00000354553 | Glycosylated lysosomal membrane protein; Chromosome 1 open reading frame 85; Belongs to the GLMP family |
| MT-CYB protein network | https://string-db.org/network/9606.ENSP00000354554 | Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates ele [...] |
| MTOR protein network | https://string-db.org/network/9606.ENSP00000354558 | Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, [...] |
| KIFAP3 protein network | https://string-db.org/network/9606.ENSP00000354560 | Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeri [...] |
| CD3E protein network | https://string-db.org/network/9606.ENSP00000354566 | T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting c [...] |
| RNF121 protein network | https://string-db.org/network/9606.ENSP00000354571 | Ring finger protein 121; Belongs to the RNF121 family |
| MACF1 protein network | https://string-db.org/network/9606.ENSP00000354573 | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; Isoform 2: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubu [...] |
| MRPL21 protein network | https://string-db.org/network/9606.ENSP00000354580 | Mitochondrial ribosomal protein L21 |
| GPX6 protein network | https://string-db.org/network/9606.ENSP00000354581 | Glutathione peroxidase 6; Selenoproteins |
| MFAP3L protein network | https://string-db.org/network/9606.ENSP00000354583 | Microfibrillar-associated protein 3-like; May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis; I-set domain containing |
| SFT2D1 protein network | https://string-db.org/network/9606.ENSP00000354590 | Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex |
| DENND4B protein network | https://string-db.org/network/9606.ENSP00000354597 | DENN domain-containing protein 4B; Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their ac [...] |
| FZD5 protein network | https://string-db.org/network/9606.ENSP00000354607 | Frizzled-5; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| PPT2 protein network | https://string-db.org/network/9606.ENSP00000354608 | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic an [...] |
| AMY2B protein network | https://string-db.org/network/9606.ENSP00000354610 | Amylase, alpha 2B; Belongs to the glycosyl hydrolase 13 family |
| PTGS1 protein network | https://string-db.org/network/9606.ENSP00000354612 | Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in t [...] |
| SMURF1 protein network | https://string-db.org/network/9606.ENSP00000354621 | E3 ubiquitin-protein ligase SMURF1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor- [...] |
| RUNDC1 protein network | https://string-db.org/network/9606.ENSP00000354622 | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity |
| DFNB31 protein network | https://string-db.org/network/9606.ENSP00000354623 | Whirlin; Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear |
| MT-ATP6 protein network | https://string-db.org/network/9606.ENSP00000354632 | ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated [...] |
| TAF11 protein network | https://string-db.org/network/9606.ENSP00000354633 | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectivel [...] |
| DIO1 protein network | https://string-db.org/network/9606.ENSP00000354643 | Type I iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in [...] |
| GPATCH3 protein network | https://string-db.org/network/9606.ENSP00000354645 | G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from the CXCR4 promoter and therefore it might control neural crest cell migratio [...] |
| MAGT1 protein network | https://string-db.org/network/9606.ENSP00000354649 | Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked o [...] |
| NPY1R protein network | https://string-db.org/network/9606.ENSP00000354652 | Neuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] [...] |
| MAGEC2 protein network | https://string-db.org/network/9606.ENSP00000354660 | Melanoma-associated antigen C2; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRI [...] |
| MT-ND6 protein network | https://string-db.org/network/9606.ENSP00000354665 | NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| FAM63A protein network | https://string-db.org/network/9606.ENSP00000354669 | Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for l [...] |
| MAST2 protein network | https://string-db.org/network/9606.ENSP00000354671 | Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modula [...] |
| GPX7 protein network | https://string-db.org/network/9606.ENSP00000354677 | Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects agai [...] |
| OPA1 protein network | https://string-db.org/network/9606.ENSP00000354681 | Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondr [...] |
| ZNF652 protein network | https://string-db.org/network/9606.ENSP00000354686 | Zinc finger protein 652; Functions as a transcriptional repressor; Zinc fingers C2H2-type |
| MT-ND1 protein network | https://string-db.org/network/9606.ENSP00000354687 | NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| FAM45A protein network | https://string-db.org/network/9606.ENSP00000354688 | Protein FAM45A; Family with sequence similarity 45 member A |
| SLC39A13 protein network | https://string-db.org/network/9606.ENSP00000354689 | Zinc transporter ZIP13; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family |
| FCRL5 protein network | https://string-db.org/network/9606.ENSP00000354691 | Fc receptor-like protein 5; May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role i [...] |
| ZNF485 protein network | https://string-db.org/network/9606.ENSP00000354694 | Zinc finger protein 485; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR10Z1 protein network | https://string-db.org/network/9606.ENSP00000354707 | Olfactory receptor 10Z1; Odorant receptor; Olfactory receptors, family 10 |
| AKAP13 protein network | https://string-db.org/network/9606.ENSP00000354718 | A-kinase anchor protein 13; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response [...] |
| SMC3 protein network | https://string-db.org/network/9606.ENSP00000354720 | Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous [...] |
| SLC26A1 protein network | https://string-db.org/network/9606.ENSP00000354721 | Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport (By similarity). Does not accept succinate as cosubstrate (B [...] |
| H2BFWT protein network | https://string-db.org/network/9606.ENSP00000354723 | Histone H2B type W-T; Atypical histone H2B. Nucleosomes containing it are structurally and dynamically indistinguishable from those containing conventional H2B. However, unlike conventional H2B, [...] |
| PCGF3 protein network | https://string-db.org/network/9606.ENSP00000354724 | Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many gene [...] |
| MT-ND4L protein network | https://string-db.org/network/9606.ENSP00000354728 | NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required fo [...] |
| CHAMP1 protein network | https://string-db.org/network/9606.ENSP00000354730 | Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle [...] |
| SBNO2 protein network | https://string-db.org/network/9606.ENSP00000354733 | Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP- repressive activity of TAL1, hence enhan [...] |
| RPL12 protein network | https://string-db.org/network/9606.ENSP00000354739 | 60S ribosomal protein L12; Binds directly to 26S ribosomal RNA |
| IPO9 protein network | https://string-db.org/network/9606.ENSP00000354742 | Importin-9; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...] |
| COA3 protein network | https://string-db.org/network/9606.ENSP00000354762 | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, t [...] |
| MVB12B protein network | https://string-db.org/network/9606.ENSP00000354772 | Multivesicular body subunit 12B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bod [...] |
| SPRYD7 protein network | https://string-db.org/network/9606.ENSP00000354774 | SPRY domain containing 7 |
| PJA2 protein network | https://string-db.org/network/9606.ENSP00000354775 | E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulator [...] |
| TBKBP1 protein network | https://string-db.org/network/9606.ENSP00000354777 | TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity |
| CNTNAP2 protein network | https://string-db.org/network/9606.ENSP00000354778 | Contactin-associated protein-like 2; Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical fo [...] |
| CD247 protein network | https://string-db.org/network/9606.ENSP00000354782 | T-cell surface glycoprotein CD3 zeta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cell [...] |
| DCTN1 protein network | https://string-db.org/network/9606.ENSP00000354791 | Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein [...] |
| ZNF521 protein network | https://string-db.org/network/9606.ENSP00000354794 | Zinc finger protein 521; Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartmen [...] |
| OR5D13 protein network | https://string-db.org/network/9606.ENSP00000354800 | Olfactory receptor 5D13; Odorant receptor; Olfactory receptors, family 5 |
| C9orf114 protein network | https://string-db.org/network/9606.ENSP00000354812 | Putative methyltransferase C9orf114; Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote [...] |
| MT-ND5 protein network | https://string-db.org/network/9606.ENSP00000354813 | NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| XAF1 protein network | https://string-db.org/network/9606.ENSP00000354822 | XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and i [...] |
| CALD1 protein network | https://string-db.org/network/9606.ENSP00000354826 | Caldesmon; Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments [...] |
| SGMS1 protein network | https://string-db.org/network/9606.ENSP00000354829 | Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, [...] |
| DDIT4L protein network | https://string-db.org/network/9606.ENSP00000354830 | DNA damage-inducible transcript 4-like protein; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1 |
| ARHGEF2 protein network | https://string-db.org/network/9606.ENSP00000354837 | Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendr [...] |
| TOX protein network | https://string-db.org/network/9606.ENSP00000354842 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development |
| KIAA1279 protein network | https://string-db.org/network/9606.ENSP00000354848 | KIF1-binding protein; Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development; Belongs to the KIF1-binding [...] |
| MGEA5 protein network | https://string-db.org/network/9606.ENSP00000354850 | Protein O-GlcNAcase; Isoform 1: Cleaves GlcNAc but not GalNAc from O- glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4- methylumbelliferone-GlcNAc as substrates but not p-nitropheny [...] |
| NFE2L1 protein network | https://string-db.org/network/9606.ENSP00000354855 | Nuclear factor erythroid 2-related factor 1; Activates erythroid-specific, globin gene expression; Basic leucine zipper proteins |
| DRD2 protein network | https://string-db.org/network/9606.ENSP00000354859 | D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family |
| PPEF1 protein network | https://string-db.org/network/9606.ENSP00000354871 | Serine/threonine-protein phosphatase with EF-hands 1; May have a role in the recovery or adaptation response of photoreceptors. May have a role in development; EF-hand domain containing |
| C17orf47 protein network | https://string-db.org/network/9606.ENSP00000354874 | Uncharacterized protein C17orf47; Chromosome 17 open reading frame 47 |
| MT-CO2 protein network | https://string-db.org/network/9606.ENSP00000354876 | Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzym [...] |
| KIF21A protein network | https://string-db.org/network/9606.ENSP00000354878 | Kinesin-like protein KIF21A; Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity); Kinesins |
| RASSF9 protein network | https://string-db.org/network/9606.ENSP00000354884 | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells; Ras association domain family |
| SLC25A47 protein network | https://string-db.org/network/9606.ENSP00000354886 | Solute carrier family 25 member 47; Uncoupling protein which may catalyze the physiological 'proton leak' in liver. Overexpression induces the dissipation of mitochondrial membrane potential; Sol [...] |
| CCDC152 protein network | https://string-db.org/network/9606.ENSP00000354888 | Coiled-coil domain containing 152 |
| FAM163A protein network | https://string-db.org/network/9606.ENSP00000354891 | Protein FAM163A; Family with sequence similarity 163 member A; Belongs to the FAM163 family |
| GRM1 protein network | https://string-db.org/network/9606.ENSP00000354896 | Metabotropic glutamate receptor 1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| CXCL9 protein network | https://string-db.org/network/9606.ENSP00000354901 | C-X-C motif chemokine 9; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to [...] |
| NRG2 protein network | https://string-db.org/network/9606.ENSP00000354910 | Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine [...] |
| TIFA protein network | https://string-db.org/network/9606.ENSP00000354911 | TRAF-interacting protein with FHA domain-containing protein A; Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of [...] |
| MAGEE1 protein network | https://string-db.org/network/9606.ENSP00000354912 | Melanoma-associated antigen E1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...] |
| CDC14A protein network | https://string-db.org/network/9606.ENSP00000354916 | Dual specificity protein phosphatase CDC14A; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early [...] |
| VEPH1 protein network | https://string-db.org/network/9606.ENSP00000354919 | Ventricular zone-expressed PH domain-containing protein homolog 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear [...] |
| METTL13 protein network | https://string-db.org/network/9606.ENSP00000354920 | Methyltransferase-like protein 13; Methyltransferase like 13; Belongs to the methyltransferase superfamily |
| DMD protein network | https://string-db.org/network/9606.ENSP00000354923 | Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin- associated glycoprotein complex which accumulates at the neurom [...] |
| MAP3K3 protein network | https://string-db.org/network/9606.ENSP00000354927 | Mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators |
| TLR1 protein network | https://string-db.org/network/9606.ENSP00000354932 | Toll-like receptor 1; Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate i [...] |
| CAPZA2 protein network | https://string-db.org/network/9606.ENSP00000354947 | F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of sub [...] |
| GAB2 protein network | https://string-db.org/network/9606.ENSP00000354952 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate mu [...] |
| SMC5 protein network | https://string-db.org/network/9606.ENSP00000354957 | Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may pro [...] |
| FAM189B protein network | https://string-db.org/network/9606.ENSP00000354958 | Protein FAM189B; Family with sequence similarity 189 member B |
| COLGALT2 protein network | https://string-db.org/network/9606.ENSP00000354960 | Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen; Belongs to the glycosyltransferase 25 family |
| MT-ND4 protein network | https://string-db.org/network/9606.ENSP00000354961 | NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| ZNF318 protein network | https://string-db.org/network/9606.ENSP00000354964 | Zinc finger protein 318; Repressed AR-mediated transcriptional activation. May act as a transcriptional regulator during spermatogenesis and, in particular, during meiotic division (By similarity [...] |
| NAA35 protein network | https://string-db.org/network/9606.ENSP00000354972 | N-alpha-acetyltransferase 35, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Invol [...] |
| MT-CO3 protein network | https://string-db.org/network/9606.ENSP00000354982 | Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex; Mitochondrial complex IV: cytochrome c oxidase subunits |
| ALPK2 protein network | https://string-db.org/network/9606.ENSP00000354991 | Alpha-protein kinase 2; Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation; I-set domain containing |
| ABCG1 protein network | https://string-db.org/network/9606.ENSP00000354995 | ATP-binding cassette sub-family G member 1; Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracel [...] |
| POU3F3 protein network | https://string-db.org/network/9606.ENSP00000355001 | POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the [...] |
| ILF2 protein network | https://string-db.org/network/9606.ENSP00000355011 | Interleukin enhancer-binding factor 2; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It [...] |
| CTR9 protein network | https://string-db.org/network/9606.ENSP00000355013 | RNA polymerase-associated protein CTR9 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of dev [...] |
| PJA1 protein network | https://string-db.org/network/9606.ENSP00000355014 | E3 ubiquitin-protein ligase Praja-1; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May b [...] |
| C16orf59 protein network | https://string-db.org/network/9606.ENSP00000355022 | Uncharacterized protein C16orf59; Chromosome 16 open reading frame 59 |
| ARHGEF15 protein network | https://string-db.org/network/9606.ENSP00000355026 | Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synap [...] |
| DZIP3 protein network | https://string-db.org/network/9606.ENSP00000355028 | E3 ubiquitin-protein ligase DZIP3; E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 [...] |
| FAM179B protein network | https://string-db.org/network/9606.ENSP00000355045 | TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cil [...] |
| MT-ND2 protein network | https://string-db.org/network/9606.ENSP00000355046 | NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| CTNNBL1 protein network | https://string-db.org/network/9606.ENSP00000355050 | Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediat [...] |
| TAF13 protein network | https://string-db.org/network/9606.ENSP00000355051 | Transcription initiation factor TFIID subunit 13; Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of [...] |
| ZSCAN20 protein network | https://string-db.org/network/9606.ENSP00000355053 | Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation; Myb/SANT domain containing |
| ARHGEF10L protein network | https://string-db.org/network/9606.ENSP00000355060 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC |
| SHISA4 protein network | https://string-db.org/network/9606.ENSP00000355064 | Protein shisa-4; Shisa family member 4 |
| NSMCE1 protein network | https://string-db.org/network/9606.ENSP00000355077 | Non-structural maintenance of chromosomes element 1 homolog; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promot [...] |
| CCDC7 protein network | https://string-db.org/network/9606.ENSP00000355078 | Coiled-coil domain-containing protein 7; May play a role in tumorigenesis |
| PCDH18 protein network | https://string-db.org/network/9606.ENSP00000355082 | Protocadherin-18; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| MSRB1 protein network | https://string-db.org/network/9606.ENSP00000355084 | Methionine-R-sulfoxide reductase B1; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result [...] |
| DARS2 protein network | https://string-db.org/network/9606.ENSP00000355086 | Aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily |
| ARHGAP11A protein network | https://string-db.org/network/9606.ENSP00000355090 | Rho GTPase activating protein 11A |
| QKI protein network | https://string-db.org/network/9606.ENSP00000355094 | Protein quaking; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)- UAAY-3' RNA core sequence. Regulates target mRNA stability. In addition, acts by [...] |
| SMOC1 protein network | https://string-db.org/network/9606.ENSP00000355110 | SPARC-related modular calcium-binding protein 1; Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation; SPARC family |
| DCAF12 protein network | https://string-db.org/network/9606.ENSP00000355114 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| ITPRIPL1 protein network | https://string-db.org/network/9606.ENSP00000355121 | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1; ITPRIP like 1 |
| KRT19 protein network | https://string-db.org/network/9606.ENSP00000355124 | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratin [...] |
| NOS1AP protein network | https://string-db.org/network/9606.ENSP00000355133 | Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex [...] |
| HOXB1 protein network | https://string-db.org/network/9606.ENSP00000355140 | Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| SEPN1 protein network | https://string-db.org/network/9606.ENSP00000355141 | Selenoprotein N; Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER b [...] |
| GRIN3A protein network | https://string-db.org/network/9606.ENSP00000355155 | Glutamate receptor ionotropic, NMDA 3A; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivi [...] |
| SUCNR1 protein network | https://string-db.org/network/9606.ENSP00000355156 | Succinate receptor 1; Receptor for succinate |
| FCRL2 protein network | https://string-db.org/network/9606.ENSP00000355157 | Fc receptor-like protein 2; May have an regulatory role in normal and neoplastic B cell development; CD molecules |
| TIGD4 protein network | https://string-db.org/network/9606.ENSP00000355162 | Tigger transposable element-derived protein 4; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| LRRC10 protein network | https://string-db.org/network/9606.ENSP00000355166 | Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function |
| HORMAD1 protein network | https://string-db.org/network/9606.ENSP00000355167 | HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks ( [...] |
| COL6A1 protein network | https://string-db.org/network/9606.ENSP00000355180 | Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family |
| DCLRE1A protein network | https://string-db.org/network/9606.ENSP00000355185 | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle p [...] |
| LRRTM3 protein network | https://string-db.org/network/9606.ENSP00000355187 | Leucine-rich repeat transmembrane neuronal protein 3; Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in t [...] |
| CACNA1S protein network | https://string-db.org/network/9606.ENSP00000355192 | Voltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calci [...] |
| ASB12 protein network | https://string-db.org/network/9606.ENSP00000355195 | Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| MAGEB3 protein network | https://string-db.org/network/9606.ENSP00000355198 | Melanoma-associated antigen B3; MAGE family member B3 |
| FAM110B protein network | https://string-db.org/network/9606.ENSP00000355204 | Protein FAM110B; May be involved in tumor progression |
| INO80 protein network | https://string-db.org/network/9606.ENSP00000355205 | DNA helicase INO80; DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA r [...] |
| MT-ND3 protein network | https://string-db.org/network/9606.ENSP00000355206 | NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for [...] |
| TMEM184B protein network | https://string-db.org/network/9606.ENSP00000355210 | Transmembrane protein 184B; May activate the MAP kinase signaling pathway |
| SNX6 protein network | https://string-db.org/network/9606.ENSP00000355217 | Sorting nexin-6; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). A [...] |
| HMGN2 protein network | https://string-db.org/network/9606.ENSP00000355228 | Non-histone chromosomal protein HMG-17; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which [...] |
| BECN1 protein network | https://string-db.org/network/9606.ENSP00000355231 | Beclin-1; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a r [...] |
| CDC42BPB protein network | https://string-db.org/network/9606.ENSP00000355237 | Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and [...] |
| C19orf45 protein network | https://string-db.org/network/9606.ENSP00000355241 | Testis-expressed protein 45; Chromosome 19 open reading frame 45 |
| PAX9 protein network | https://string-db.org/network/9606.ENSP00000355245 | Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as dista [...] |
| E2F2 protein network | https://string-db.org/network/9606.ENSP00000355249 | Transcription factor E2F2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of ge [...] |
| KIAA0753 protein network | https://string-db.org/network/9606.ENSP00000355250 | Protein moonraker; Involved in centriole duplication. Positively regulates CEP63 centrosomal localization. Required for WDR62 centrosomal localization and promotes the centrosomal localization of [...] |
| ZNF511 protein network | https://string-db.org/network/9606.ENSP00000355251 | Zinc finger protein 511; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PPP1R14C protein network | https://string-db.org/network/9606.ENSP00000355260 | Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA |
| SMG5 protein network | https://string-db.org/network/9606.ENSP00000355261 | Protein SMG5; Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA [...] |
| MT-ATP8 protein network | https://string-db.org/network/9606.ENSP00000355265 | ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated [...] |
| CNOT7 protein network | https://string-db.org/network/9606.ENSP00000355279 | CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalyti [...] |
| TSEN15 protein network | https://string-db.org/network/9606.ENSP00000355299 | tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. I [...] |
| KRTAP1-5 protein network | https://string-db.org/network/9606.ENSP00000355302 | Keratin-associated protein 1-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| MOK protein network | https://string-db.org/network/9606.ENSP00000355304 | MAPK/MAK/MRK overlapping kinase; Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent [...] |
| C1orf174 protein network | https://string-db.org/network/9606.ENSP00000355306 | UPF0688 protein C1orf174; Chromosome 1 open reading frame 174; Belongs to the UPF0688 family |
| PTPLA protein network | https://string-db.org/network/9606.ENSP00000355308 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 1; Isoform 1: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymat [...] |
| RPL39 protein network | https://string-db.org/network/9606.ENSP00000355315 | Ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family |
| GRM3 protein network | https://string-db.org/network/9606.ENSP00000355316 | Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| CIPC protein network | https://string-db.org/network/9606.ENSP00000355319 | CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulat [...] |
| PSMB5 protein network | https://string-db.org/network/9606.ENSP00000355325 | Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| TGM2 protein network | https://string-db.org/network/9606.ENSP00000355330 | Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Transglutaminases |
| APOBEC3C protein network | https://string-db.org/network/9606.ENSP00000355340 | DNA dC->dU-editing enzyme APOBEC-3C; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| SOX15 protein network | https://string-db.org/network/9606.ENSP00000355354 | Protein SOX-15; Binds to the 5'-AACAAT-3' sequence; SRY-boxes |
| CD47 protein network | https://string-db.org/network/9606.ENSP00000355361 | Leukocyte surface antigen CD47; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory fo [...] |
| CNTF protein network | https://string-db.org/network/9606.ENSP00000355370 | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy; Interleukin 6 type cytokine family |
| OSGIN1 protein network | https://string-db.org/network/9606.ENSP00000355374 | Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation of normal cells through the regulation of cell death; Belongs to the OKL38 family |
| AKR7A3 protein network | https://string-db.org/network/9606.ENSP00000355377 | Aflatoxin B1 aldehyde reductase member 3; Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against t [...] |
| SLC26A11 protein network | https://string-db.org/network/9606.ENSP00000355384 | Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high end [...] |
| R3HDM4 protein network | https://string-db.org/network/9606.ENSP00000355385 | R3H domain containing 4 |
| SCAMP5 protein network | https://string-db.org/network/9606.ENSP00000355387 | Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE ma [...] |
| MPHOSPH8 protein network | https://string-db.org/network/9606.ENSP00000355388 | M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic r [...] |
| LRIG2 protein network | https://string-db.org/network/9606.ENSP00000355396 | Leucine rich repeats and immunoglobulin like domains 2; I-set domain containing |
| ISLR2 protein network | https://string-db.org/network/9606.ENSP00000355402 | Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development; Immunoglobulin like domain containing |
| GAGE2A protein network | https://string-db.org/network/9606.ENSP00000355421 | G antigen 2A |
| SH3BP5L protein network | https://string-db.org/network/9606.ENSP00000355428 | Functions as guanine nucleotide exchange factor (GEF) for RAB11A |
| OR2T5 protein network | https://string-db.org/network/9606.ENSP00000355429 | Olfactory receptor 2T5; Odorant receptor; Olfactory receptors, family 2 |
| OR2T1 protein network | https://string-db.org/network/9606.ENSP00000355430 | Olfactory receptor 2T1; Odorant receptor; Olfactory receptors, family 2 |
| OR2T4 protein network | https://string-db.org/network/9606.ENSP00000355431 | Olfactory receptor 2T4; Odorant receptor; Olfactory receptors, family 2 |
| OR2M5 protein network | https://string-db.org/network/9606.ENSP00000355432 | Olfactory receptor 2M5; Odorant receptor; Olfactory receptors, family 2 |
| OR2L13 protein network | https://string-db.org/network/9606.ENSP00000355434 | Olfactory receptor 2L13; Odorant receptor; Olfactory receptors, family 2 |
| OR2L2 protein network | https://string-db.org/network/9606.ENSP00000355435 | Olfactory receptor 2L2; Odorant receptor; Olfactory receptors, family 2 |
| OR2AK2 protein network | https://string-db.org/network/9606.ENSP00000355436 | Olfactory receptor 2AK2; Odorant receptor; Olfactory receptors, family 2 |
| TRIM58 protein network | https://string-db.org/network/9606.ENSP00000355437 | E3 ubiquitin-protein ligase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1 [...] |
| OR14A2 protein network | https://string-db.org/network/9606.ENSP00000355441 | Olfactory receptor 14A2; Odorant receptor; Olfactory receptors, family 14 |
| OR2C3 protein network | https://string-db.org/network/9606.ENSP00000355443 | Olfactory receptor 2C3; Odorant receptor; Olfactory receptors, family 2 |
| ZNF670 protein network | https://string-db.org/network/9606.ENSP00000355459 | Zinc finger protein 670; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| AHCTF1 protein network | https://string-db.org/network/9606.ENSP00000355465 | Protein ELYS; Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chro [...] |
| SCCPDH protein network | https://string-db.org/network/9606.ENSP00000355467 | Saccharopine dehydrogenase-like oxidoreductase; Saccharopine dehydrogenase; Belongs to the saccharopine dehydrogenase family |
| CNST protein network | https://string-db.org/network/9606.ENSP00000355470 | Consortin; Required for targeting of connexins to the plasma membrane; Protein phosphatase 1 regulatory subunits |
| TFB2M protein network | https://string-db.org/network/9606.ENSP00000355471 | Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also require [...] |
| EFCAB2 protein network | https://string-db.org/network/9606.ENSP00000355480 | EF-hand calcium-binding domain-containing protein 2; EF-hand calcium binding domain 2; Cilia and flagella associated |
| C1orf101 protein network | https://string-db.org/network/9606.ENSP00000355492 | Cation channel sperm-associated protein subunit epsilon; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for spe [...] |
| ADSS protein network | https://string-db.org/network/9606.ENSP00000355493 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosy [...] |
| SDCCAG8 protein network | https://string-db.org/network/9606.ENSP00000355499 | Serologically defined colon cancer antigen 8; Plays a role in the establishment of cell polarity and epithelial lumen formation (By similarity). May play a role in ciliogenesis; Bardet-Biedl synd [...] |
| CEP170 protein network | https://string-db.org/network/9606.ENSP00000355500 | Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly; Belongs to the CEP170 family |
| EXO1 protein network | https://string-db.org/network/9606.ENSP00000355506 | Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- [...] |
| WDR64 protein network | https://string-db.org/network/9606.ENSP00000355510 | WD repeat-containing protein 64; WD repeat domain containing |
| CHML protein network | https://string-db.org/network/9606.ENSP00000355511 | Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents t [...] |
| OPN3 protein network | https://string-db.org/network/9606.ENSP00000355512 | Opsin-3; May play a role in encephalic photoreception; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily |
| KMO protein network | https://string-db.org/network/9606.ENSP00000355517 | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor an [...] |
| FH protein network | https://string-db.org/network/9606.ENSP00000355518 | Fumarate hydratase, mitochondrial; Also acts as a tumor suppressor; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily |
| RGS7 protein network | https://string-db.org/network/9606.ENSP00000355523 | Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...] |
| RYR2 protein network | https://string-db.org/network/9606.ENSP00000355533 | Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. [...] |
| MTR protein network | https://string-db.org/network/9606.ENSP00000355536 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor us [...] |
| HEATR1 protein network | https://string-db.org/network/9606.ENSP00000355541 | HEAT repeat-containing protein 1; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; [...] |
| GPR137B protein network | https://string-db.org/network/9606.ENSP00000355551 | Integral membrane protein GPR137B; G protein-coupled receptor 137B; Belongs to the GPR137 family |
| B3GALNT2 protein network | https://string-db.org/network/9606.ENSP00000355559 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1- 3GlcNAc, on N- and O-glycans. [...] |
| TOMM20 protein network | https://string-db.org/network/9606.ENSP00000355566 | Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preprot [...] |
| IRF2BP2 protein network | https://string-db.org/network/9606.ENSP00000355568 | Interferon regulatory factor 2-binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses t [...] |
| COA6 protein network | https://string-db.org/network/9606.ENSP00000355572 | Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV a [...] |
| SLC35F3 protein network | https://string-db.org/network/9606.ENSP00000355577 | Putative thiamine transporter SLC35F3; May be a thiamine transporter; Belongs to the SLC35F solute transporter family |
| KCNK1 protein network | https://string-db.org/network/9606.ENSP00000355580 | Potassium channel subfamily K member 1; Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but [...] |
| KIAA1804 protein network | https://string-db.org/network/9606.ENSP00000355583 | Mitogen-activated protein kinase kinase kinase 21; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways; Belongs to the protein kinase s [...] |
| NTPCR protein network | https://string-db.org/network/9606.ENSP00000355587 | Cancer-related nucleoside-triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NT [...] |
| SIPA1L2 protein network | https://string-db.org/network/9606.ENSP00000355589 | Signal-induced proliferation-associated 1-like protein 2; Signal induced proliferation associated 1 like 2; PDZ domain containing |
| DISC1 protein network | https://string-db.org/network/9606.ENSP00000355593 | Disrupted in schizophrenia 1 protein; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrica [...] |
| TSNAX protein network | https://string-db.org/network/9606.ENSP00000355599 | Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis |
| EGLN1 protein network | https://string-db.org/network/9606.ENSP00000355601 | Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...] |
| EXOC8 protein network | https://string-db.org/network/9606.ENSP00000355605 | Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the EXO84 family |
| GNPAT protein network | https://string-db.org/network/9606.ENSP00000355607 | Glyceronephosphate O-acyltransferase |
| C1orf131 protein network | https://string-db.org/network/9606.ENSP00000355609 | Uncharacterized protein C1orf131; Chromosome 1 open reading frame 131 |
| TRIM67 protein network | https://string-db.org/network/9606.ENSP00000355613 | Tripartite motif-containing protein 67; Fibronectin type III domain containing; Belongs to the TRIM/RBCC family |
| FAM89A protein network | https://string-db.org/network/9606.ENSP00000355614 | Protein FAM89A; Family with sequence similarity 89 member A; Belongs to the FAM89 family |
| TTC13 protein network | https://string-db.org/network/9606.ENSP00000355621 | Tetratricopeptide repeat domain containing |
| C1orf198 protein network | https://string-db.org/network/9606.ENSP00000355623 | Uncharacterized protein C1orf198; Chromosome 1 open reading frame 198 |
| AGT protein network | https://string-db.org/network/9606.ENSP00000355627 | Angiotensinogen; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis; Endogenous ligands |
| COG2 protein network | https://string-db.org/network/9606.ENSP00000355629 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function; Belongs to the COG2 family |
| GALNT2 protein network | https://string-db.org/network/9606.ENSP00000355632 | Polypeptide N-acetylgalactosaminyltransferase 2; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| ABCB10 protein network | https://string-db.org/network/9606.ENSP00000355637 | ATP-binding cassette sub-family B member 10, mitochondrial; May mediate critical mitochondrial transport functions related to heme biosynthesis; Belongs to the ABC transporter superfamily. ABCB f [...] |
| ACTA1 protein network | https://string-db.org/network/9606.ENSP00000355645 | Actin, alpha skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| SPHAR protein network | https://string-db.org/network/9606.ENSP00000355649 | Protein SPHAR; S-phase response |
| RAB4A protein network | https://string-db.org/network/9606.ENSP00000355651 | Ras-related protein Rab-4A; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases |
| RHOU protein network | https://string-db.org/network/9606.ENSP00000355652 | Rho-related GTP-binding protein RhoU; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle [...] |
| HIST3H2A protein network | https://string-db.org/network/9606.ENSP00000355656 | Histone H2A type 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones [...] |
| HIST3H3 protein network | https://string-db.org/network/9606.ENSP00000355657 | Histone H3.1t; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...] |
| TRIM17 protein network | https://string-db.org/network/9606.ENSP00000355658 | E3 ubiquitin-protein ligase TRIM17; May function as a ubiquitin E3 ligase; Belongs to the TRIM/RBCC family |
| IBA57 protein network | https://string-db.org/network/9606.ENSP00000355672 | Putative transferase CAF17, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway |
| GJC2 protein network | https://string-db.org/network/9606.ENSP00000355675 | Gap junction gamma-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| GUK1 protein network | https://string-db.org/network/9606.ENSP00000355689 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP |
| DLL1 protein network | https://string-db.org/network/9606.ENSP00000355718 | Delta-like protein 1; Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following [...] |
| PRSS38 protein network | https://string-db.org/network/9606.ENSP00000355719 | Serine protease 38 |
| JMJD4 protein network | https://string-db.org/network/9606.ENSP00000355720 | JmjC domain-containing protein 4; Jumonji domain containing 4 |
| CDC42BPA protein network | https://string-db.org/network/9606.ENSP00000355731 | Serine/threonine-protein kinase MRCK alpha; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization an [...] |
| ERMARD protein network | https://string-db.org/network/9606.ENSP00000355735 | Endoplasmic reticulum membrane-associated RNA degradation protein; May play a role in neuronal migration during embryonic development |
| TCTE3 protein network | https://string-db.org/network/9606.ENSP00000355736 | Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity); Belongs to the dynein l [...] |
| ADCK3 protein network | https://string-db.org/network/9606.ENSP00000355741 | Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respi [...] |
| PSEN2 protein network | https://string-db.org/network/9606.ENSP00000355747 | Presenilin-2; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors an [...] |
| THBS2 protein network | https://string-db.org/network/9606.ENSP00000355751 | Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties |
| C1orf95 protein network | https://string-db.org/network/9606.ENSP00000355752 | Protein stum homolog; Chromosome 1 open reading frame 95 |
| PARP1 protein network | https://string-db.org/network/9606.ENSP00000355759 | Poly [ADP-ribose] polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin archite [...] |
| DACT2 protein network | https://string-db.org/network/9606.ENSP00000355760 | Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation [...] |
| ACBD3 protein network | https://string-db.org/network/9606.ENSP00000355777 | Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in horm [...] |
| H3F3A protein network | https://string-db.org/network/9606.ENSP00000355778 | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorpo [...] |
| LEFTY2 protein network | https://string-db.org/network/9606.ENSP00000355785 | Left-right determination factor 2; Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding |
| TCP10L2 protein network | https://string-db.org/network/9606.ENSP00000355797 | T-complex protein 10A homolog 2; T-complex 10 like 2; Belongs to the TCP10 family |
| GPR31 protein network | https://string-db.org/network/9606.ENSP00000355799 | 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secr [...] |
| TMEM63A protein network | https://string-db.org/network/9606.ENSP00000355800 | CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel |
| ENAH protein network | https://string-db.org/network/9606.ENSP00000355809 | Protein enabled homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellip [...] |
| FGFR1OP protein network | https://string-db.org/network/9606.ENSP00000355812 | FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes. Required for ciliation |
| FBXO28 protein network | https://string-db.org/network/9606.ENSP00000355827 | F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other |
| CAPN8 protein network | https://string-db.org/network/9606.ENSP00000355837 | Calpain-8; Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells [...] |
| CCDC185 protein network | https://string-db.org/network/9606.ENSP00000355840 | Coiled-coil domain containing 185 |
| PARK2 protein network | https://string-db.org/network/9606.ENSP00000355865 | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SY [...] |
| DUSP10 protein network | https://string-db.org/network/9606.ENSP00000355866 | Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphor [...] |
| HLX protein network | https://string-db.org/network/9606.ENSP00000355870 | H2.0-like homeobox protein; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and h [...] |
| MARC1 protein network | https://string-db.org/network/9606.ENSP00000355877 | Mitochondrial amidoxime-reducing component 1; As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce [...] |
| MARC2 protein network | https://string-db.org/network/9606.ENSP00000355880 | Mitochondrial amidoxime reducing component 2; As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce [...] |
| IARS2 protein network | https://string-db.org/network/9606.ENSP00000355889 | Isoleucine--tRNA ligase, mitochondrial; isoleucyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I |
| EPRS protein network | https://string-db.org/network/9606.ENSP00000355890 | Bifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form [...] |
| SLC30A10 protein network | https://string-db.org/network/9606.ENSP00000355893 | Zinc transporter 10; Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of ne [...] |
| LYPLAL1 protein network | https://string-db.org/network/9606.ENSP00000355895 | Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates du [...] |
| TGFB2 protein network | https://string-db.org/network/9606.ENSP00000355896 | Transforming growth factor beta-2; TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth; Endogenous ligands |
| RRP15 protein network | https://string-db.org/network/9606.ENSP00000355899 | RRP15-like protein; Ribosomal RNA processing 15 homolog |
| SPATA17 protein network | https://string-db.org/network/9606.ENSP00000355900 | Spermatogenesis-associated protein 17; Spermatogenesis associated 17 |
| GPATCH2 protein network | https://string-db.org/network/9606.ENSP00000355902 | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing |
| ESRRG protein network | https://string-db.org/network/9606.ENSP00000355904 | Estrogen-related receptor gamma; Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter gen [...] |
| SLC22A2 protein network | https://string-db.org/network/9606.ENSP00000355920 | Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, fa [...] |
| CENPF protein network | https://string-db.org/network/9606.ENSP00000355922 | Centromere protein F; Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the pl [...] |
| PTPN14 protein network | https://string-db.org/network/9606.ENSP00000355923 | Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell- matrix adhesion, cell migra [...] |
| SMYD2 protein network | https://string-db.org/network/9606.ENSP00000355924 | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 'Lys-4' [...] |
| PROX1 protein network | https://string-db.org/network/9606.ENSP00000355925 | Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number o [...] |
| RPS6KC1 protein network | https://string-db.org/network/9606.ENSP00000355927 | Ribosomal protein S6 kinase delta-1; May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell |
| ANGEL2 protein network | https://string-db.org/network/9606.ENSP00000355929 | Angel homolog 2 |
| SLC22A1 protein network | https://string-db.org/network/9606.ENSP00000355930 | Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tet [...] |
| FLVCR1 protein network | https://string-db.org/network/9606.ENSP00000355938 | Feline leukemia virus subgroup C receptor-related protein 1; Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both int [...] |
| NSL1 protein network | https://string-db.org/network/9606.ENSP00000355944 | Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis |
| NENF protein network | https://string-db.org/network/9606.ENSP00000355955 | Neudesin; Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the e [...] |
| DTL protein network | https://string-db.org/network/9606.ENSP00000355958 | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA sy [...] |
| INTS7 protein network | https://string-db.org/network/9606.ENSP00000355961 | Integrator complex subunit 7; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| LPGAT1 protein network | https://string-db.org/network/9606.ENSP00000355964 | Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear pref [...] |
| NEK2 protein network | https://string-db.org/network/9606.ENSP00000355966 | Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic [...] |
| SLC30A1 protein network | https://string-db.org/network/9606.ENSP00000355968 | Zinc transporter 1; May be involved in zinc transport out of the cell; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily |
| RD3 protein network | https://string-db.org/network/9606.ENSP00000355969 | Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors (PubMed:29515371, PubMed:21928830, PubMed:21078983, PubMed:27471269, PubMed:30559291). Inhibits t [...] |
| SERTAD4 protein network | https://string-db.org/network/9606.ENSP00000355979 | SERTA domain containing 4 |
| SYT14 protein network | https://string-db.org/network/9606.ENSP00000355986 | Synaptotagmin-14; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Belongs to the synaptotagmin family |
| IRF6 protein network | https://string-db.org/network/9606.ENSP00000355988 | Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal developm [...] |
| TRAF3IP3 protein network | https://string-db.org/network/9606.ENSP00000355991 | TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3-mediated JNK activation |
| HSD11B1 protein network | https://string-db.org/network/9606.ENSP00000355995 | Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7 [...] |
| G0S2 protein network | https://string-db.org/network/9606.ENSP00000355996 | G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers |
| PLXNA2 protein network | https://string-db.org/network/9606.ENSP00000356000 | Plexin-A2; Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growt [...] |
| MRPL18 protein network | https://string-db.org/network/9606.ENSP00000356001 | 39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperon [...] |
| ACAT2 protein network | https://string-db.org/network/9606.ENSP00000356015 | Acetyl-CoA acetyltransferase, cytosolic; acetyl-CoA acetyltransferase 2 |
| CR1 protein network | https://string-db.org/network/9606.ENSP00000356016 | Complement receptor type 1; Mediates cellular binding of particles and immune complexes that have activated complement; Blood group antigens |
| CR2 protein network | https://string-db.org/network/9606.ENSP00000356024 | Complement receptor type 2; Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRNPU. Participates in B lymphocytes activation; CD molecules |
| CD55 protein network | https://string-db.org/network/9606.ENSP00000356030 | Complement decay-accelerating factor; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during [...] |
| TAGAP protein network | https://string-db.org/network/9606.ENSP00000356033 | T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein and may play important roles during T-cell activation |
| C4BPA protein network | https://string-db.org/network/9606.ENSP00000356037 | C4b-binding protein alpha chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b [...] |
| EZR protein network | https://string-db.org/network/9606.ENSP00000356042 | Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical p [...] |
| PFKFB2 protein network | https://string-db.org/network/9606.ENSP00000356047 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family |
| DYNLT1 protein network | https://string-db.org/network/9606.ENSP00000356056 | Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to a [...] |
| TMEM181 protein network | https://string-db.org/network/9606.ENSP00000356057 | Transmembrane protein 181; Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication |
| FAIM3 protein network | https://string-db.org/network/9606.ENSP00000356058 | Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitor [...] |
| TULP4 protein network | https://string-db.org/network/9606.ENSP00000356064 | Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent [...] |
| IL20 protein network | https://string-db.org/network/9606.ENSP00000356065 | Interleukin-20; Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through [...] |
| MAPKAPK2 protein network | https://string-db.org/network/9606.ENSP00000356070 | MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycl [...] |
| SERAC1 protein network | https://string-db.org/network/9606.ENSP00000356071 | Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remode [...] |
| DYRK3 protein network | https://string-db.org/network/9606.ENSP00000356076 | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Negative regulator of EPO-dependent ery [...] |
| C1orf186 protein network | https://string-db.org/network/9606.ENSP00000356093 | Uncharacterized protein C1orf186; Chromosome 1 open reading frame 186 |
| AVPR1B protein network | https://string-db.org/network/9606.ENSP00000356094 | Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system; Argin [...] |
| FAM72A protein network | https://string-db.org/network/9606.ENSP00000356096 | Protein FAM72A; May play a role in the regulation of cellular reactive oxygen species metabolism. May participate in cell growth regulation; Belongs to the FAM72 family |
| SLC26A9 protein network | https://string-db.org/network/9606.ENSP00000356102 | Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independe [...] |
| PM20D1 protein network | https://string-db.org/network/9606.ENSP00000356104 | N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endoge [...] |
| SLC41A1 protein network | https://string-db.org/network/9606.ENSP00000356105 | Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Solute carriers |
| RAB29 protein network | https://string-db.org/network/9606.ENSP00000356107 | Ras-related protein Rab-7L1; Rab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans- Golgi network structure. Together with LRRK2, plays a [...] |
| NUCKS1 protein network | https://string-db.org/network/9606.ENSP00000356110 | Nuclear casein kinase and cyclin dependent kinase substrate 1 |
| SLC45A3 protein network | https://string-db.org/network/9606.ENSP00000356113 | Solute carrier family 45 member 3; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family |
| MFSD4 protein network | https://string-db.org/network/9606.ENSP00000356115 | Major facilitator superfamily domain containing 4 |
| LEMD1 protein network | https://string-db.org/network/9606.ENSP00000356121 | LEM domain containing 1 |
| KLHDC8A protein network | https://string-db.org/network/9606.ENSP00000356124 | Kelch domain containing 8A |
| NUAK2 protein network | https://string-db.org/network/9606.ENSP00000356125 | NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induce [...] |
| DSTYK protein network | https://string-db.org/network/9606.ENSP00000356130 | Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of bo [...] |
| CLDN20 protein network | https://string-db.org/network/9606.ENSP00000356133 | Claudin-20; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| TFB1M protein network | https://string-db.org/network/9606.ENSP00000356134 | Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also require [...] |
| TMEM81 protein network | https://string-db.org/network/9606.ENSP00000356135 | Transmembrane protein 81; Immunoglobulin like domain containing |
| LRRN2 protein network | https://string-db.org/network/9606.ENSP00000356143 | Leucine rich repeat neuronal 2; I-set domain containing |
| MDM4 protein network | https://string-db.org/network/9606.ENSP00000356150 | Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted de [...] |
| PIK3C2B protein network | https://string-db.org/network/9606.ENSP00000356155 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved [...] |
| PPP1R15B protein network | https://string-db.org/network/9606.ENSP00000356156 | Protein phosphatase 1 regulatory subunit 15B; Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1; Belongs to the PPP1R15 family |
| KISS1 protein network | https://string-db.org/network/9606.ENSP00000356162 | Metastasis-suppressor KiSS-1; Metastasis suppressor protein in malignant melanomas and in some breast cancers. May regulate events downstream of cell- matrix adhesion, perhaps involving cytoskele [...] |
| ETNK2 protein network | https://string-db.org/network/9606.ENSP00000356169 | Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity (By similarity); Belongs to the choline/ethanolamine kinase family |
| SOX13 protein network | https://string-db.org/network/9606.ENSP00000356172 | Transcription factor SOX-13; Binds to the sequence 5'-AACAAT-3'; SRY-boxes |
| OPTC protein network | https://string-db.org/network/9606.ENSP00000356191 | Opticin; Binds collagen fibrils; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily |
| RGS17 protein network | https://string-db.org/network/9606.ENSP00000356194 | Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits [...] |
| CHIT1 protein network | https://string-db.org/network/9606.ENSP00000356198 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity; Belongs to the glycosyl [...] |
| MTRF1L protein network | https://string-db.org/network/9606.ENSP00000356202 | Peptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA [...] |
| ADORA1 protein network | https://string-db.org/network/9606.ENSP00000356205 | Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family |
| TMEM183A protein network | https://string-db.org/network/9606.ENSP00000356211 | Transmembrane protein 183A |
| VIP protein network | https://string-db.org/network/9606.ENSP00000356213 | VIP peptides; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bla [...] |
| MYCT1 protein network | https://string-db.org/network/9606.ENSP00000356214 | Myc target protein 1; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpressio [...] |
| CYB5R1 protein network | https://string-db.org/network/9606.ENSP00000356218 | NADH-cytochrome b5 reductase 1; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemogl [...] |
| SYNE1 protein network | https://string-db.org/network/9606.ENSP00000356224 | Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC [...] |
| KLHL12 protein network | https://string-db.org/network/9606.ENSP00000356230 | Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(K [...] |
| RABIF protein network | https://string-db.org/network/9606.ENSP00000356231 | Guanine nucleotide exchange factor MSS4; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less act [...] |
| KDM5B protein network | https://string-db.org/network/9606.ENSP00000356234 | Lysine-specific demethylase 5B; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27' [...] |
| SYT2 protein network | https://string-db.org/network/9606.ENSP00000356236 | Synaptotagmin-2; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking [...] |
| UBE2T protein network | https://string-db.org/network/9606.ENSP00000356243 | Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induc [...] |
| LGR6 protein network | https://string-db.org/network/9606.ENSP00000356247 | Leucine-rich repeat-containing G-protein coupled receptor 6; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epi [...] |
| GPR37L1 protein network | https://string-db.org/network/9606.ENSP00000356251 | Prosaposin receptor GPR37L1; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade; G protein-coupl [...] |
| TIMM17A protein network | https://string-db.org/network/9606.ENSP00000356256 | Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across [...] |
| LMOD1 protein network | https://string-db.org/network/9606.ENSP00000356257 | Leiomodin-1; Mediates nucleation of actin filaments; Belongs to the tropomodulin family |
| C6orf211 protein network | https://string-db.org/network/9606.ENSP00000356263 | Protein-glutamate O-methyltransferase; O-methyltransferase that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Methylates PCNA, suggesting it is in [...] |
| NAV1 protein network | https://string-db.org/network/9606.ENSP00000356265 | Neuron navigator 1; May be involved in neuronal migration |
| RMND1 protein network | https://string-db.org/network/9606.ENSP00000356272 | Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome; Belongs to the [...] |
| CSRP1 protein network | https://string-db.org/network/9606.ENSP00000356275 | Cysteine and glycine-rich protein 1; Could play a role in neuronal development; LIM domain containing |
| PHLDA3 protein network | https://string-db.org/network/9606.ENSP00000356280 | Pleckstrin homology-like domain family A member 3; p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 transl [...] |
| PLEKHG1 protein network | https://string-db.org/network/9606.ENSP00000356297 | Pleckstrin homology and RhoGEF domain containing G1 |
| TMEM9 protein network | https://string-db.org/network/9606.ENSP00000356301 | Transmembrane protein 9; May be involved in intracellular transport |
| ULBP3 protein network | https://string-db.org/network/9606.ENSP00000356308 | UL16-binding protein 3; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity |
| RAET1L protein network | https://string-db.org/network/9606.ENSP00000356310 | UL16-binding protein 6; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity |
| KIF14 protein network | https://string-db.org/network/9606.ENSP00000356319 | Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in ma [...] |
| ULBP2 protein network | https://string-db.org/network/9606.ENSP00000356320 | UL16-binding protein 2; Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity; Belongs to the MHC class I family |
| RAET1G protein network | https://string-db.org/network/9606.ENSP00000356329 | UL-16 binding protein 5; Isoform 1: Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity |
| NR5A2 protein network | https://string-db.org/network/9606.ENSP00000356331 | Nuclear receptor subfamily 5 group A member 2; Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and r [...] |
| PCMT1 protein network | https://string-db.org/network/9606.ENSP00000356354 | Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D-aspartyl residues in peptides and proteins that result from spontaneous decompo [...] |
| NEK7 protein network | https://string-db.org/network/9606.ENSP00000356355 | Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitoti [...] |
| LHX9 protein network | https://string-db.org/network/9606.ENSP00000356357 | LIM/homeobox protein Lhx9; Involved in gonadal development; LIM class homeoboxes |
| C1orf53 protein network | https://string-db.org/network/9606.ENSP00000356363 | Uncharacterized protein C1orf53; Chromosome 1 open reading frame 53 |
| CRB1 protein network | https://string-db.org/network/9606.ENSP00000356370 | Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion; Belongs to the Crumbs protein family |
| ZBTB41 protein network | https://string-db.org/network/9606.ENSP00000356375 | Zinc finger and BTB domain-containing protein 41; May be involved in transcriptional regulation; BTB domain containing |
| ASPM protein network | https://string-db.org/network/9606.ENSP00000356379 | Abnormal spindle-like microcephaly-associated protein; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle pol [...] |
| KATNA1 protein network | https://string-db.org/network/9606.ENSP00000356381 | Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular mi [...] |
| F13B protein network | https://string-db.org/network/9606.ENSP00000356382 | Coagulation factor XIII B chain; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin [...] |
| FHR2 protein network | https://string-db.org/network/9606.ENSP00000356385 | Complement factor H-related 2; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement [...] |
| CFHR4 protein network | https://string-db.org/network/9606.ENSP00000356386 | Complement factor H-related protein 4; Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism |
| GINM1 protein network | https://string-db.org/network/9606.ENSP00000356389 | Glycoprotein integral membrane 1 |
| ENSG00000276911 protein network | https://string-db.org/network/9606.ENSP00000356391 | Complement factor H-related protein 2; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological com [...] |
| CFHR3 protein network | https://string-db.org/network/9606.ENSP00000356395 | Complement factor H-related protein 3; Might be involved in complement regulation |
| CFH protein network | https://string-db.org/network/9606.ENSP00000356399 | Complement factor H; Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB comp [...] |
| B3GALT2 protein network | https://string-db.org/network/9606.ENSP00000356404 | Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. Can als [...] |
| CDC73 protein network | https://string-db.org/network/9606.ENSP00000356405 | Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 [...] |
| GLRX2 protein network | https://string-db.org/network/9606.ENSP00000356410 | Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved i [...] |
| TROVE2 protein network | https://string-db.org/network/9606.ENSP00000356416 | 60 kDa SS-A/Ro ribonucleoprotein; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of thes [...] |
| UCHL5 protein network | https://string-db.org/network/9606.ENSP00000356425 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of th [...] |
| TAB2 protein network | https://string-db.org/network/9606.ENSP00000356426 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiqu [...] |
| RGS1 protein network | https://string-db.org/network/9606.ENSP00000356429 | Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene recept [...] |
| RGS18 protein network | https://string-db.org/network/9606.ENSP00000356430 | Regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G [...] |
| BRINP3 protein network | https://string-db.org/network/9606.ENSP00000356432 | BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, [...] |
| UST protein network | https://string-db.org/network/9606.ENSP00000356433 | Uronyl 2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weak [...] |
| PLA2G4A protein network | https://string-db.org/network/9606.ENSP00000356436 | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the [...] |
| SASH1 protein network | https://string-db.org/network/9606.ENSP00000356437 | SAM and SH3 domain-containing protein 1; May have a role in a signaling pathway. Could act as a tumor suppressor; SAM and SH3 domain containing |
| PTGS2 protein network | https://string-db.org/network/9606.ENSP00000356438 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, suc [...] |
| SAMD5 protein network | https://string-db.org/network/9606.ENSP00000356444 | Sterile alpha motif domain containing 5 |
| TPR protein network | https://string-db.org/network/9606.ENSP00000356448 | Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the [...] |
| RAB32 protein network | https://string-db.org/network/9606.ENSP00000356465 | Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchron [...] |
| IVNS1ABP protein network | https://string-db.org/network/9606.ENSP00000356468 | Influenza virus NS1A-binding protein; Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Ke [...] |
| SWT1 protein network | https://string-db.org/network/9606.ENSP00000356470 | Transcriptional protein SWT1; SWT1, RNA endoribonuclease homolog |
| SHPRH protein network | https://string-db.org/network/9606.ENSP00000356475 | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of P [...] |
| TRMT1L protein network | https://string-db.org/network/9606.ENSP00000356476 | TRMT1-like protein; May play a role in motor coordination and exploratory behavior; tRNA methyltransferases |
| RNF2 protein network | https://string-db.org/network/9606.ENSP00000356480 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene re [...] |
| FAM129A protein network | https://string-db.org/network/9606.ENSP00000356481 | Protein Niban; Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress resp [...] |
| EPM2A protein network | https://string-db.org/network/9606.ENSP00000356489 | Laforin; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitinati [...] |
| NCF2 protein network | https://string-db.org/network/9606.ENSP00000356505 | Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production); Tetratricopeptide repe [...] |
| UTRN protein network | https://string-db.org/network/9606.ENSP00000356515 | Utrophin; May play a role in anchoring the cytoskeleton to the plasma membrane; Zinc fingers ZZ-type |
| SHCBP1L protein network | https://string-db.org/network/9606.ENSP00000356518 | Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindl [...] |
| DHX9 protein network | https://string-db.org/network/9606.ENSP00000356520 | ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA re [...] |
| RGS16 protein network | https://string-db.org/network/9606.ENSP00000356529 | Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...] |
| RNASEL protein network | https://string-db.org/network/9606.ENSP00000356530 | 2-5A-dependent ribonuclease; Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects th [...] |
| TEDDM1 protein network | https://string-db.org/network/9606.ENSP00000356536 | Transmembrane epididymal protein 1 |
| STX11 protein network | https://string-db.org/network/9606.ENSP00000356540 | Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network; Syntaxins |
| SF3B5 protein network | https://string-db.org/network/9606.ENSP00000356541 | Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U [...] |
| CACNA1E protein network | https://string-db.org/network/9606.ENSP00000356545 | Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| LTV1 protein network | https://string-db.org/network/9606.ENSP00000356548 | Protein LTV1 homolog; LTV1 ribosome biogenesis factor |
| IER5 protein network | https://string-db.org/network/9606.ENSP00000356549 | Immediate early response gene 5 protein; Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1- [...] |
| KIAA1614 protein network | https://string-db.org/network/9606.ENSP00000356560 | Uncharacterized protein KIAA1614; KIAA1614 |
| XPR1 protein network | https://string-db.org/network/9606.ENSP00000356562 | Xenotropic and polytropic retrovirus receptor 1; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyp [...] |
| PEX3 protein network | https://string-db.org/network/9606.ENSP00000356563 | Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is nece [...] |
| LHX4-AS1 protein network | https://string-db.org/network/9606.ENSP00000356567 | Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very wea [...] |
| QSOX1 protein network | https://string-db.org/network/9606.ENSP00000356574 | Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond [...] |
| HIVEP2 protein network | https://string-db.org/network/9606.ENSP00000356575 | Transcription factor HIVEP2; This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, [...] |
| CEP350 protein network | https://string-db.org/network/9606.ENSP00000356579 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to th [...] |
| GPR126 protein network | https://string-db.org/network/9606.ENSP00000356581 | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins a [...] |
| TOR1AIP2 protein network | https://string-db.org/network/9606.ENSP00000356584 | Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TO [...] |
| NPHS2 protein network | https://string-db.org/network/9606.ENSP00000356587 | Podocin; Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton |
| AXDND1 protein network | https://string-db.org/network/9606.ENSP00000356590 | Axonemal dynein light chain domain containing 1 |
| SOAT1 protein network | https://string-db.org/network/9606.ENSP00000356591 | Sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary choles [...] |
| TOR3A protein network | https://string-db.org/network/9606.ENSP00000356599 | Torsin-3A; Minor histocompatibility antigens |
| VTA1 protein network | https://string-db.org/network/9606.ENSP00000356602 | Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invaginati [...] |
| RALGPS2 protein network | https://string-db.org/network/9606.ENSP00000356607 | Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the s [...] |
| RASAL2 protein network | https://string-db.org/network/9606.ENSP00000356621 | Ras GTPase-activating protein nGAP; Inhibitory regulator of the Ras-cyclic AMP pathway; C2 and RasGAP domain containing |
| HECA protein network | https://string-db.org/network/9606.ENSP00000356630 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system a [...] |
| ABRACL protein network | https://string-db.org/network/9606.ENSP00000356632 | Costars family protein ABRACL; ABRA C-terminal like; Belongs to the costars family |
| PAPPA2 protein network | https://string-db.org/network/9606.ENSP00000356634 | Pappalysin-2; Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the '163-Ser-|- Lys-164' bond. Shows limited proteolysis toward IGFBP-3; Belong [...] |
| RFWD2 protein network | https://string-db.org/network/9606.ENSP00000356641 | E3 ubiquitin-protein ligase RFWD2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from a [...] |
| TNR protein network | https://string-db.org/network/9606.ENSP00000356646 | Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a s [...] |
| CACYBP protein network | https://string-db.org/network/9606.ENSP00000356652 | Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 com [...] |
| GPR52 protein network | https://string-db.org/network/9606.ENSP00000356658 | G-protein coupled receptor 52; Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization. May play a role in locomotor activit [...] |
| RC3H1 protein network | https://string-db.org/network/9606.ENSP00000356669 | Roquin-1; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, [...] |
| SERPINC1 protein network | https://string-db.org/network/9606.ENSP00000356671 | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and X [...] |
| ZBTB37 protein network | https://string-db.org/network/9606.ENSP00000356674 | Zinc finger and BTB domain-containing protein 37; May be involved in transcriptional regulation; BTB domain containing |
| SLC9C2 protein network | https://string-db.org/network/9606.ENSP00000356687 | Sodium/hydrogen exchanger 11; Involved in pH regulation; Solute carriers |
| FASLG protein network | https://string-db.org/network/9606.ENSP00000356694 | Tumor necrosis factor ligand superfamily member 6; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, [...] |
| SUCO protein network | https://string-db.org/network/9606.ENSP00000356696 | SUN domain-containing ossification factor; Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation (By similarit [...] |
| C1orf105 protein network | https://string-db.org/network/9606.ENSP00000356700 | Uncharacterized protein C1orf105; Chromosome 1 open reading frame 105 |
| PIGC protein network | https://string-db.org/network/9606.ENSP00000356702 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...] |
| DNM3 protein network | https://string-db.org/network/9606.ENSP00000356705 | Dynamin-3; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, [...] |
| OLIG3 protein network | https://string-db.org/network/9606.ENSP00000356708 | Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons; Ba [...] |
| IFNGR1 protein network | https://string-db.org/network/9606.ENSP00000356713 | Interferon gamma receptor 1; Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway; CD molecul [...] |
| FMO4 protein network | https://string-db.org/network/9606.ENSP00000356723 | Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides |
| FMO3 protein network | https://string-db.org/network/9606.ENSP00000356729 | Dimethylaniline monooxygenase [N-oxide-forming] 3; Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as [...] |
| MROH9 protein network | https://string-db.org/network/9606.ENSP00000356733 | Maestro heat like repeat family member 9 |
| GORAB protein network | https://string-db.org/network/9606.ENSP00000356737 | Golgin, RAB6 interacting |
| SCYL3 protein network | https://string-db.org/network/9606.ENSP00000356746 | Protein-associating with the carboxyl-terminal domain of ezrin; May play a role in regulating cell adhesion/migration complexes in migrating cells; SCY1 like pseudokinases |
| F5 protein network | https://string-db.org/network/9606.ENSP00000356771 | Coagulation factor V; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin |
| AHI1 protein network | https://string-db.org/network/9606.ENSP00000356774 | Jouberin; Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tec [...] |
| CCDC181 protein network | https://string-db.org/network/9606.ENSP00000356780 | Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids; Belongs to the CCDC181 family |
| BLZF1 protein network | https://string-db.org/network/9606.ENSP00000356782 | Golgin-45; Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface |
| NME7 protein network | https://string-db.org/network/9606.ENSP00000356785 | Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...] |
| ATP1B1 protein network | https://string-db.org/network/9606.ENSP00000356790 | Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) io [...] |
| DPT protein network | https://string-db.org/network/9606.ENSP00000356791 | Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. E [...] |
| XCL1 protein network | https://string-db.org/network/9606.ENSP00000356792 | Lymphotactin; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell d [...] |
| XCL2 protein network | https://string-db.org/network/9606.ENSP00000356793 | Cytokine SCM-1 beta; Chemotactic activity for lymphocytes but not for monocytes or neutrophils; Chemokine ligands |
| TBX19 protein network | https://string-db.org/network/9606.ENSP00000356795 | T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulati [...] |
| TIPRL protein network | https://string-db.org/network/9606.ENSP00000356807 | TIP41-like protein; May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL [...] |
| HBS1L protein network | https://string-db.org/network/9606.ENSP00000356811 | HBS1-like protein; HBS1 like translational GTPase; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family |
| DCAF6 protein network | https://string-db.org/network/9606.ENSP00000356814 | DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor [...] |
| MPC2 protein network | https://string-db.org/network/9606.ENSP00000356820 | Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria; Solute carriers |
| ADCY10 protein network | https://string-db.org/network/9606.ENSP00000356825 | Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critic [...] |
| RCSD1 protein network | https://string-db.org/network/9606.ENSP00000356828 | CapZ-interacting protein; Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly |
| SGK1 protein network | https://string-db.org/network/9606.ENSP00000356832 | Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription [...] |
| POU2F1 protein network | https://string-db.org/network/9606.ENSP00000356840 | POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and [...] |
| GPA33 protein network | https://string-db.org/network/9606.ENSP00000356842 | Cell surface A33 antigen; May play a role in cell-cell recognition and signaling; IgCAM CXADR-related subfamily |
| MAEL protein network | https://string-db.org/network/9606.ENSP00000356846 | Protein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts v [...] |
| TADA1 protein network | https://string-db.org/network/9606.ENSP00000356848 | Transcriptional adapter 1; Probably involved in transcriptional regulation; SAGA complex |
| POGK protein network | https://string-db.org/network/9606.ENSP00000356849 | Pogo transposable element derived with KRAB domain; DNA transposon derived genes |
| UCK2 protein network | https://string-db.org/network/9606.ENSP00000356853 | Uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use [...] |
| TCF21 protein network | https://string-db.org/network/9606.ENSP00000356857 | Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in t [...] |
| MGST3 protein network | https://string-db.org/network/9606.ENSP00000356864 | Microsomal glutathione S-transferase 3; Also functions as a glutathione peroxidase; Microsomal glutathione S-transferases |
| C1orf110 protein network | https://string-db.org/network/9606.ENSP00000356886 | Coiled-coil domain-containing protein 190; Chromosome 1 open reading frame 110 |
| DDR2 protein network | https://string-db.org/network/9606.ENSP00000356899 | Discoidin domain-containing receptor 2; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, [...] |
| UAP1 protein network | https://string-db.org/network/9606.ENSP00000356903 | UDP-N-acetylhexosamine pyrophosphorylase; Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, wh [...] |
| VNN1 protein network | https://string-db.org/network/9606.ENSP00000356905 | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the ca [...] |
| SH2D1B protein network | https://string-db.org/network/9606.ENSP00000356906 | SH2 domain-containing protein 1B; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling se [...] |
| TAAR2 protein network | https://string-db.org/network/9606.ENSP00000356908 | Trace amine-associated receptor 2; Orphan receptor; Belongs to the G-protein coupled receptor 1 family |
| C1orf111 protein network | https://string-db.org/network/9606.ENSP00000356912 | Spermatogenesis-associated protein 46; Play a role in spermiogenesis and fertilization |
| OLFML2B protein network | https://string-db.org/network/9606.ENSP00000356917 | Olfactomedin-like protein 2B; Olfactomedin like 2B |
| STX7 protein network | https://string-db.org/network/9606.ENSP00000356918 | Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking f [...] |
| ATF6 protein network | https://string-db.org/network/9606.ENSP00000356919 | Cyclic AMP-dependent transcription factor ATF-6 alpha; Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein respo [...] |
| DUSP12 protein network | https://string-db.org/network/9606.ENSP00000356920 | Dual specificity protein phosphatase 12; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in [...] |
| FCRLB protein network | https://string-db.org/network/9606.ENSP00000356925 | Fc receptor-like B; Immunoglobulin like domain containing |
| FCRLA protein network | https://string-db.org/network/9606.ENSP00000356936 | Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis; Immunoglobulin like domain containing |
| MOXD1 protein network | https://string-db.org/network/9606.ENSP00000356940 | Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family |
| FCGR3A protein network | https://string-db.org/network/9606.ENSP00000356946 | Low affinity immunoglobulin gamma Fc region receptor III-A; Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytot [...] |
| C1orf192 protein network | https://string-db.org/network/9606.ENSP00000356951 | Protein Flattop; Acts as a regulator of cilium basal body docking and positioning in mono- and multiciliated cells. Regulates basal body docking and cilia formation in multiciliated lung cells. R [...] |
| SDHC protein network | https://string-db.org/network/9606.ENSP00000356953 | Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport [...] |
| CTGF protein network | https://string-db.org/network/9606.ENSP00000356954 | Connective tissue growth factor; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and d [...] |
| NR1I3 protein network | https://string-db.org/network/9606.ENSP00000356959 | Nuclear receptor subfamily 1 group I member 3; Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase [...] |
| TOMM40L protein network | https://string-db.org/network/9606.ENSP00000356967 | Mitochondrial import receptor subunit TOM40B; Potential channel-forming protein implicated in import of protein precursors into mitochondria; Belongs to the Tom40 family |
| APOA2 protein network | https://string-db.org/network/9606.ENSP00000356969 | Apolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Apolipoproteins |
| NDUFS2 protein network | https://string-db.org/network/9606.ENSP00000356972 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the [...] |
| ADAMTS4 protein network | https://string-db.org/network/9606.ENSP00000356975 | A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of [...] |
| PPOX protein network | https://string-db.org/network/9606.ENSP00000356978 | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX |
| USP21 protein network | https://string-db.org/network/9606.ENSP00000356981 | Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A r [...] |
| UFC1 protein network | https://string-db.org/network/9606.ENSP00000356982 | Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage |
| DEDD protein network | https://string-db.org/network/9606.ENSP00000356985 | Death effector domain-containing protein; A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating [...] |
| NIT1 protein network | https://string-db.org/network/9606.ENSP00000356988 | Deaminated glutathione amidase; Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmf [...] |
| PFDN2 protein network | https://string-db.org/network/9606.ENSP00000356989 | Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| KLHDC9 protein network | https://string-db.org/network/9606.ENSP00000356990 | Kelch domain containing 9 |
| PVRL4 protein network | https://string-db.org/network/9606.ENSP00000356991 | Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for [...] |
| ARHGAP30 protein network | https://string-db.org/network/9606.ENSP00000356992 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42 |
| USF1 protein network | https://string-db.org/network/9606.ENSP00000357000 | Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters; Basic helix-loop- [...] |
| F11R protein network | https://string-db.org/network/9606.ENSP00000357005 | Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6- [...] |
| ITLN2 protein network | https://string-db.org/network/9606.ENSP00000357008 | Intelectin-2; May play a role in the defense system against pathogens; Fibrinogen C domain containing |
| CD244 protein network | https://string-db.org/network/9606.ENSP00000357012 | Natural killer cell receptor 2B4; Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-c [...] |
| SLAMF7 protein network | https://string-db.org/network/9606.ENSP00000357022 | SLAM family member 7; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...] |
| SLAMF6 protein network | https://string-db.org/network/9606.ENSP00000357036 | SLAM family member 6; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating t [...] |
| VANGL2 protein network | https://string-db.org/network/9606.ENSP00000357040 | Vang-like protein 2; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar c [...] |
| MED23 protein network | https://string-db.org/network/9606.ENSP00000357047 | Mediator of RNA polymerase II transcription subunit 23; Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator [...] |
| COPA protein network | https://string-db.org/network/9606.ENSP00000357048 | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynt [...] |
| PEX19 protein network | https://string-db.org/network/9606.ENSP00000357051 | Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stab [...] |
| WDR42A protein network | https://string-db.org/network/9606.ENSP00000357052 | DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| PEA15 protein network | https://string-db.org/network/9606.ENSP00000357055 | Astrocytic phosphoprotein PEA-15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By [...] |
| CASQ1 protein network | https://string-db.org/network/9606.ENSP00000357057 | Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic re [...] |
| ATP1A4 protein network | https://string-db.org/network/9606.ENSP00000357060 | Sodium/potassium-transporting ATPase subunit alpha-4; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...] |
| IGSF8 protein network | https://string-db.org/network/9606.ENSP00000357065 | Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and [...] |
| KCNJ9 protein network | https://string-db.org/network/9606.ENSP00000357067 | G protein-activated inward rectifier potassium channel 3; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium [...] |
| KCNJ10 protein network | https://string-db.org/network/9606.ENSP00000357068 | ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a grea [...] |
| PIGM protein network | https://string-db.org/network/9606.ENSP00000357069 | GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly; B [...] |
| SLAMF9 protein network | https://string-db.org/network/9606.ENSP00000357072 | SLAM family member 9; May play a role in the immune response; V-set domain containing |
| IGSF9 protein network | https://string-db.org/network/9606.ENSP00000357073 | Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation; Belongs to the immunoglobulin superfamily. Turtle family |
| TAGLN2 protein network | https://string-db.org/network/9606.ENSP00000357076 | Transgelin-2; Transgelin 2 |
| CFAP45 protein network | https://string-db.org/network/9606.ENSP00000357079 | Cilia and flagella associated protein 45; Belongs to the CFAP45 family |
| VSIG8 protein network | https://string-db.org/network/9606.ENSP00000357080 | V-set and immunoglobulin domain containing 8; IgCAM CXADR-related subfamily |
| C1orf204 protein network | https://string-db.org/network/9606.ENSP00000357082 | Putative uncharacterized protein SNHG28; Chromosome 1 open reading frame 204 |
| FCRL6 protein network | https://string-db.org/network/9606.ENSP00000357086 | Fc receptor-like protein 6; Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic [...] |
| DUSP23 protein network | https://string-db.org/network/9606.ENSP00000357087 | Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAP [...] |
| FCER1A protein network | https://string-db.org/network/9606.ENSP00000357097 | High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding o [...] |
| ACKR1 protein network | https://string-db.org/network/9606.ENSP00000357103 | Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...] |
| CADM3 protein network | https://string-db.org/network/9606.ENSP00000357106 | Cell adhesion molecule 3; Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activit [...] |
| AIM2 protein network | https://string-db.org/network/9606.ENSP00000357112 | Interferon-inducible protein AIM2; Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon bi [...] |
| IFI16 protein network | https://string-db.org/network/9606.ENSP00000357113 | Gamma-interferon-inducible protein 16; Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May fun [...] |
| PYHIN1 protein network | https://string-db.org/network/9606.ENSP00000357122 | Pyrin and HIN domain-containing protein 1; Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads t [...] |
| MNDA protein network | https://string-db.org/network/9606.ENSP00000357123 | Myeloid cell nuclear differentiation antigen; May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell- specific response to interfer [...] |
| TMEM244 protein network | https://string-db.org/network/9606.ENSP00000357125 | Transmembrane protein 244 |
| OR6K6 protein network | https://string-db.org/network/9606.ENSP00000357126 | Olfactory receptor 6K6; Odorant receptor; Olfactory receptors, family 6 |
| OR6K3 protein network | https://string-db.org/network/9606.ENSP00000357127 | Olfactory receptor 6K3; Odorant receptor; Olfactory receptors, family 6 |
| SPTA1 protein network | https://string-db.org/network/9606.ENSP00000357129 | Spectrin alpha chain, erythrocytic 1; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the c [...] |
| ARHGAP18 protein network | https://string-db.org/network/9606.ENSP00000357131 | Rho GTPase-activating protein 18; Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an i [...] |
| OR10X1 protein network | https://string-db.org/network/9606.ENSP00000357132 | Olfactory receptor 10X1; Odorant receptor; Olfactory receptors, family 10 |
| OR10R2 protein network | https://string-db.org/network/9606.ENSP00000357134 | Olfactory receptor 10R2; Odorant receptor; Olfactory receptors, family 10 |
| CD1E protein network | https://string-db.org/network/9606.ENSP00000357149 | T-cell surface glycoprotein CD1e, membrane-associated; T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and [...] |
| CD1B protein network | https://string-db.org/network/9606.ENSP00000357150 | T-cell surface glycoprotein CD1b; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells; C1-set dom [...] |
| CD1C protein network | https://string-db.org/network/9606.ENSP00000357152 | T-cell surface glycoprotein CD1c; Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells; C1-set dom [...] |
| CD1D protein network | https://string-db.org/network/9606.ENSP00000357153 | Antigen-presenting glycoprotein CD1d; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells; C1-set domain containing |
| CD5L protein network | https://string-db.org/network/9606.ENSP00000357156 | CD5 antigen-like; Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflammed tissues and regulates mechanisms in inflammatory resp [...] |
| FCRL1 protein network | https://string-db.org/network/9606.ENSP00000357158 | Fc receptor-like protein 1; May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation; CD molecules |
| FCRL3 protein network | https://string-db.org/network/9606.ENSP00000357167 | Fc receptor-like protein 3; Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of [...] |
| ETV3 protein network | https://string-db.org/network/9606.ENSP00000357175 | ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferati [...] |
| ARHGEF11 protein network | https://string-db.org/network/9606.ENSP00000357177 | Rho guanine nucleotide exchange factor 11; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchang [...] |
| INSRR protein network | https://string-db.org/network/9606.ENSP00000357178 | Insulin receptor-related protein; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular s [...] |
| HDGF protein network | https://string-db.org/network/9606.ENSP00000357189 | Hepatoma-derived growth factor; Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor; Heparin binding growth factor family |
| PTPRK protein network | https://string-db.org/network/9606.ENSP00000357196 | Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR si [...] |
| RRNAD1 protein network | https://string-db.org/network/9606.ENSP00000357199 | Protein RRNAD1; Ribosomal RNA adenine dimethylase domain containing 1; Belongs to the RRNAD1 family |
| NES protein network | https://string-db.org/network/9606.ENSP00000357206 | Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribut [...] |
| APOA1BP protein network | https://string-db.org/network/9606.ENSP00000357218 | NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisi [...] |
| TTC24 protein network | https://string-db.org/network/9606.ENSP00000357219 | Tetratricopeptide repeat domain containing |
| THEMIS protein network | https://string-db.org/network/9606.ENSP00000357231 | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lin [...] |
| TSACC protein network | https://string-db.org/network/9606.ENSP00000357238 | TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family |
| BGLAP protein network | https://string-db.org/network/9606.ENSP00000357255 | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium; Gla domain containing |
| PMF1 protein network | https://string-db.org/network/9606.ENSP00000357256 | Polyamine-modulated factor 1; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription pa [...] |
| PMF1-BGLAP protein network | https://string-db.org/network/9606.ENSP00000357259 | Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in re [...] |
| SEMA4A protein network | https://string-db.org/network/9606.ENSP00000357268 | Semaphorin-4A; Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Plays a role in priming antigen-specific T-cells, promotes differen [...] |
| LMNA protein network | https://string-db.org/network/9606.ENSP00000357283 | Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelop [...] |
| LAMTOR2 protein network | https://string-db.org/network/9606.ENSP00000357288 | Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...] |
| UBQLN4 protein network | https://string-db.org/network/9606.ENSP00000357292 | Ubiquilin-4; Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradati [...] |
| RNF146 protein network | https://string-db.org/network/9606.ENSP00000357297 | E3 ubiquitin-protein ligase RNF146; E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. Ma [...] |
| RXFP4 protein network | https://string-db.org/network/9606.ENSP00000357301 | Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation; Belongs to t [...] |
| KIAA0907 protein network | https://string-db.org/network/9606.ENSP00000357304 | Protein BLOM7; RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site [...] |
| RIT1 protein network | https://string-db.org/network/9606.ENSP00000357305 | GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved i [...] |
| SYT11 protein network | https://string-db.org/network/9606.ENSP00000357307 | Synaptotagmin-11; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ve [...] |
| CENPW protein network | https://string-db.org/network/9606.ENSP00000357308 | Constitutive centromere associated network |
| GON4L protein network | https://string-db.org/network/9606.ENSP00000357315 | GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis; Myb/SANT domain containing |
| DAP3 protein network | https://string-db.org/network/9606.ENSP00000357320 | 28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death; Belongs to the mitochondrion-specific ribosomal protein mS29 family |
| YY1AP1 protein network | https://string-db.org/network/9606.ENSP00000357323 | YY1-associated protein 1; Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activati [...] |
| RUSC1 protein network | https://string-db.org/network/9606.ENSP00000357336 | RUN and SH3 domain-containing protein 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF- dependent neurite outgrowth. Proposed [...] |
| HCN3 protein network | https://string-db.org/network/9606.ENSP00000357342 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3; Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions; Cyclic nucleotide [...] |
| CLK2 protein network | https://string-db.org/network/9606.ENSP00000357345 | Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spl [...] |
| HEY2 protein network | https://string-db.org/network/9606.ENSP00000357348 | Hairy/enhancer-of-split related with YRPW motif protein 2; Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds prefe [...] |
| MTX1 protein network | https://string-db.org/network/9606.ENSP00000357360 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity) |
| THBS3 protein network | https://string-db.org/network/9606.ENSP00000357362 | Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen |
| DPM3 protein network | https://string-db.org/network/9606.ENSP00000357384 | Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER |
| SLC50A1 protein network | https://string-db.org/network/9606.ENSP00000357389 | Sugar transporter SWEET1; Mediates sugar transport across membranes. May stimulate V(D)J recombination by the activation of RAG1; Solute carriers |
| EFNA1 protein network | https://string-db.org/network/9606.ENSP00000357392 | Ephrin-A1; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...] |
| EFNA3 protein network | https://string-db.org/network/9606.ENSP00000357393 | Ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...] |
| NKAIN2 protein network | https://string-db.org/network/9606.ENSP00000357402 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2; Sodium/potassium transporting ATPase interacting 2 |
| DCST2 protein network | https://string-db.org/network/9606.ENSP00000357409 | DC-STAMP domain containing 2 |
| SMPDL3A protein network | https://string-db.org/network/9606.ENSP00000357425 | Acid sphingomyelinase-like phosphodiesterase 3a; Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has l [...] |
| FABP7 protein network | https://string-db.org/network/9606.ENSP00000357429 | Fatty acid-binding protein, brain; B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for [...] |
| HSF2 protein network | https://string-db.org/network/9606.ENSP00000357440 | Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unl [...] |
| PYGO2 protein network | https://string-db.org/network/9606.ENSP00000357442 | Pygopus homolog 2; Involved in signal transduction through the Wnt pathway; PHD finger proteins |
| PBXIP1 protein network | https://string-db.org/network/9606.ENSP00000357448 | Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks [...] |
| PMVK protein network | https://string-db.org/network/9606.ENSP00000357452 | Phosphomevalonate kinase |
| MAN1A1 protein network | https://string-db.org/network/9606.ENSP00000357453 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce [...] |
| ADAR protein network | https://string-db.org/network/9606.ENSP00000357459 | Double-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect ge [...] |
| CHRNB2 protein network | https://string-db.org/network/9606.ENSP00000357461 | Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-cond [...] |
| TDRD10 protein network | https://string-db.org/network/9606.ENSP00000357465 | Tudor domain-containing protein 10; RNA binding motif containing |
| IL6R protein network | https://string-db.org/network/9606.ENSP00000357470 | Interleukin-6 receptor subunit alpha; Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL [...] |
| CEP85L protein network | https://string-db.org/network/9606.ENSP00000357474 | Centrosomal protein 85 like; Belongs to the CEP85 family |
| ATP8B2 protein network | https://string-db.org/network/9606.ENSP00000357475 | Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| NUS1 protein network | https://string-db.org/network/9606.ENSP00000357480 | Dehydrodolichyl diphosphate synthase complex subunit NUS1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) b [...] |
| GOPC protein network | https://string-db.org/network/9606.ENSP00000357484 | Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 curren [...] |
| ROS1 protein network | https://string-db.org/network/9606.ENSP00000357494 | Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. M [...] |
| C1orf43 protein network | https://string-db.org/network/9606.ENSP00000357507 | Uncharacterized protein C1orf43; Chromosome 1 open reading frame 43 |
| C1orf189 protein network | https://string-db.org/network/9606.ENSP00000357511 | Uncharacterized protein C1orf189; Chromosome 1 open reading frame 189 |
| TPM3 protein network | https://string-db.org/network/9606.ENSP00000357516 | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebra [...] |
| ECHS1 protein network | https://string-db.org/network/9606.ENSP00000357535 | Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate. Has high substrate specificity for croto [...] |
| FAM162B protein network | https://string-db.org/network/9606.ENSP00000357545 | Protein FAM162B; Family with sequence similarity 162 member B |
| NUP210L protein network | https://string-db.org/network/9606.ENSP00000357547 | Nuclear pore membrane glycoprotein 210-like; Nucleoporin 210 like; Belongs to the NUP210 family |
| KPNA5 protein network | https://string-db.org/network/9606.ENSP00000357552 | Importin subunit alpha-6; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| RPS27 protein network | https://string-db.org/network/9606.ENSP00000357555 | 40S ribosomal protein S27; Component of the small ribosomal subunit. Required for proper rRNA processing and maturation of 18S rRNAs; Belongs to the eukaryotic ribosomal protein eS27 family |
| VENTX protein network | https://string-db.org/network/9606.ENSP00000357556 | Homeobox protein VENTX; May be involved in ventralization; NKL subclass homeoboxes and pseudogenes |
| RAB13 protein network | https://string-db.org/network/9606.ENSP00000357564 | Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| ZUFSP protein network | https://string-db.org/network/9606.ENSP00000357565 | Zinc finger with UFM1-specific peptidase domain |
| CFAP46 protein network | https://string-db.org/network/9606.ENSP00000357575 | Cilia- and flagella-associated protein 46; As part of the central apparatus of the cilium axoneme plays a role in cilium movement; Cilia and flagella associated |
| NKX6-2 protein network | https://string-db.org/network/9606.ENSP00000357581 | Homeobox protein Nkx-6.2; Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA se [...] |
| INPP5A protein network | https://string-db.org/network/9606.ENSP00000357583 | Type I inositol 1,4,5-trisphosphate 5-phosphatase; Major isoenzyme hydrolyzing the calcium-mobilizing second messenger Ins(1,4,5)P3, this is a signal-terminating reaction; Belongs to the inositol [...] |
| FAM26E protein network | https://string-db.org/network/9606.ENSP00000357588 | Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel |
| TRAPPC3L protein network | https://string-db.org/network/9606.ENSP00000357591 | Trafficking protein particle complex subunit 3-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily |
| FAM26F protein network | https://string-db.org/network/9606.ENSP00000357594 | Calcium homeostasis modulator protein 6; Pore-forming subunit of a voltage-gated ion channel |
| CREB3L4 protein network | https://string-db.org/network/9606.ENSP00000357596 | Cyclic AMP-responsive element-binding protein 3-like protein 4; Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE ele [...] |
| TSPYL1 protein network | https://string-db.org/network/9606.ENSP00000357597 | Testis-specific Y-encoded-like protein 1; TSPY like 1 |
| LRRC27 protein network | https://string-db.org/network/9606.ENSP00000357603 | Leucine-rich repeat-containing protein 27; Leucine rich repeat containing 27 |
| SLC39A1 protein network | https://string-db.org/network/9606.ENSP00000357612 | Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologic [...] |
| CRTC2 protein network | https://string-db.org/network/9606.ENSP00000357622 | CREB-regulated transcription coactivator 2; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coa [...] |
| BNIP3 protein network | https://string-db.org/network/9606.ENSP00000357625 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellu [...] |
| TCERG1L protein network | https://string-db.org/network/9606.ENSP00000357631 | Transcription elongation regulator 1 like |
| GLRX3 protein network | https://string-db.org/network/9606.ENSP00000357633 | Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts as a crit [...] |
| EBF3 protein network | https://string-db.org/network/9606.ENSP00000357637 | Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity); Belongs to the COE family |
| MKI67 protein network | https://string-db.org/network/9606.ENSP00000357643 | Proliferation marker protein Ki-67; Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitot [...] |
| GATAD2B protein network | https://string-db.org/network/9606.ENSP00000357644 | Transcriptional repressor p66-beta; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucle [...] |
| FAM229B protein network | https://string-db.org/network/9606.ENSP00000357645 | Protein FAM229B; Family with sequence similarity 229 member B; Belongs to the FAM229 family |
| TUBE1 protein network | https://string-db.org/network/9606.ENSP00000357651 | Belongs to the tubulin family |
| WISP3 protein network | https://string-db.org/network/9606.ENSP00000357655 | WNT1-inducible-signaling pathway protein 3; Appears to be required for normal postnatal skeletal growth and cartilage homeostasis; CYR61/CTGF/NOV matricellular proteins |
| CLRN3 protein network | https://string-db.org/network/9606.ENSP00000357660 | Clarin-3; Clarin 3; Belongs to the clarin family |
| ADAM12 protein network | https://string-db.org/network/9606.ENSP00000357668 | Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells [...] |
| NPR1 protein network | https://string-db.org/network/9606.ENSP00000357669 | Atrial natriuretic peptide receptor 1; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in c [...] |
| SNAPIN protein network | https://string-db.org/network/9606.ENSP00000357674 | SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melano [...] |
| CHTOP protein network | https://string-db.org/network/9606.ENSP00000357679 | Chromatin target of PRMT1 protein; Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits t [...] |
| FANK1 protein network | https://string-db.org/network/9606.ENSP00000357682 | Fibronectin type 3 and ankyrin repeat domains protein 1; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis; Ankyrin repeat domain containing |
| S100A13 protein network | https://string-db.org/network/9606.ENSP00000357688 | Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding o [...] |
| S100A14 protein network | https://string-db.org/network/9606.ENSP00000357691 | Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apop [...] |
| S100A16 protein network | https://string-db.org/network/9606.ENSP00000357693 | Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro) (By similarity). Overexpression in preadipocytes increases their [...] |
| S100A2 protein network | https://string-db.org/network/9606.ENSP00000357697 | Protein S100-A2; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and in [...] |
| S100A3 protein network | https://string-db.org/network/9606.ENSP00000357702 | Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation; S100 calcium binding proteins |
| S100A4 protein network | https://string-db.org/network/9606.ENSP00000357705 | S100 calcium binding protein A4; EF-hand domain containing |
| S100A5 protein network | https://string-db.org/network/9606.ENSP00000357707 | Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites; E [...] |
| S100A6 protein network | https://string-db.org/network/9606.ENSP00000357709 | Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and in [...] |
| S100A7 protein network | https://string-db.org/network/9606.ENSP00000357712 | S100 calcium binding protein A7; EF-hand domain containing |
| S100A7L2 protein network | https://string-db.org/network/9606.ENSP00000357714 | S100 calcium binding protein A7 like 2; EF-hand domain containing |
| S100A7A protein network | https://string-db.org/network/9606.ENSP00000357718 | Protein S100-A7A; May be involved in epidermal differentiation and inflammation and might therefore be important for the pathogenesis of psoriasis and other diseases; EF-hand domain containing |
| S100A8 protein network | https://string-db.org/network/9606.ENSP00000357722 | Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis an [...] |
| S100A12 protein network | https://string-db.org/network/9606.ENSP00000357726 | Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activit [...] |
| S100A9 protein network | https://string-db.org/network/9606.ENSP00000357727 | Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, a [...] |
| LOR protein network | https://string-db.org/network/9606.ENSP00000357731 | Loricrin; Major keratinocyte cell envelope protein; Cornified envelope precursor family |
| PRR9 protein network | https://string-db.org/network/9606.ENSP00000357733 | Proline-rich protein 9; Proline rich 9 |
| LELP1 protein network | https://string-db.org/network/9606.ENSP00000357736 | Late cornified envelope like proline rich 1; Belongs to the cornifin (SPRR) family |
| SPRR2G protein network | https://string-db.org/network/9606.ENSP00000357737 | Small proline-rich protein 2G; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| SPRR2E protein network | https://string-db.org/network/9606.ENSP00000357740 | Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| SPRR2B protein network | https://string-db.org/network/9606.ENSP00000357744 | Small proline-rich protein 2B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| SPRR2D protein network | https://string-db.org/network/9606.ENSP00000357746 | Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| BCCIP protein network | https://string-db.org/network/9606.ENSP00000357748 | BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spind [...] |
| TRAF3IP2 protein network | https://string-db.org/network/9606.ENSP00000357750 | Adapter protein CIKS; Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK |
| SPRR1A protein network | https://string-db.org/network/9606.ENSP00000357751 | Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transg [...] |
| IVL protein network | https://string-db.org/network/9606.ENSP00000357753 | Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia; Belongs to the involucrin family |
| SMCP protein network | https://string-db.org/network/9606.ENSP00000357754 | Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced s [...] |
| LCE1E protein network | https://string-db.org/network/9606.ENSP00000357759 | Late cornified envelope protein 1E; Precursors of the cornified envelope of the stratum corneum |
| C1orf68 protein network | https://string-db.org/network/9606.ENSP00000357764 | Skin-specific protein 32; Chromosome 1 open reading frame 68 |
| LCE4A protein network | https://string-db.org/network/9606.ENSP00000357766 | Late cornified envelope protein 4A; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| LCE2A protein network | https://string-db.org/network/9606.ENSP00000357768 | Late cornified envelope protein 2A; Precursors of the cornified envelope of the stratum corneum |
| LCE2B protein network | https://string-db.org/network/9606.ENSP00000357769 | Late cornified envelope protein 2B; Precursors of the cornified envelope of the stratum corneum |
| LCE2C protein network | https://string-db.org/network/9606.ENSP00000357772 | Late cornified envelope protein 2C; Precursors of the cornified envelope of the stratum |
| LCE2D protein network | https://string-db.org/network/9606.ENSP00000357773 | Late cornified envelope protein 2D; Precursors of the cornified envelope of the stratum corneum |
| LCE3D protein network | https://string-db.org/network/9606.ENSP00000357776 | Late cornified envelope protein 3D; Precursors of the cornified envelope of the stratum corneum; Belongs to the LCE family |
| LCE3E protein network | https://string-db.org/network/9606.ENSP00000357778 | Late cornified envelope protein 3E; Precursors of the cornified envelope of the stratum corneum |
| CRCT1 protein network | https://string-db.org/network/9606.ENSP00000357779 | Cysteine rich C-terminal 1 |
| UROS protein network | https://string-db.org/network/9606.ENSP00000357787 | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leadin [...] |
| FLG protein network | https://string-db.org/network/9606.ENSP00000357789 | Filaggrin; Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis; EF-hand domain [...] |
| HRNR protein network | https://string-db.org/network/9606.ENSP00000357791 | Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family |
| TCHHL1 protein network | https://string-db.org/network/9606.ENSP00000357796 | S100 fused type protein family; Belongs to the S-100 family |
| MMP21 protein network | https://string-db.org/network/9606.ENSP00000357798 | Matrix metalloproteinase-21; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha [...] |
| S100A10 protein network | https://string-db.org/network/9606.ENSP00000357801 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of [...] |
| THEM4 protein network | https://string-db.org/network/9606.ENSP00000357804 | Acyl-coenzyme A thioesterase THEM4; Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid [...] |
| THEM5 protein network | https://string-db.org/network/9606.ENSP00000357807 | Acyl-coenzyme A thioesterase THEM5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-c [...] |
| LINGO4 protein network | https://string-db.org/network/9606.ENSP00000357810 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4; Leucine rich repeat and Ig domain containing 4 |
| TEX36 protein network | https://string-db.org/network/9606.ENSP00000357811 | Testis-expressed protein 36; Testis expressed 36 |
| TDRKH protein network | https://string-db.org/network/9606.ENSP00000357812 | Tudor and KH domain-containing protein; Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization [...] |
| MRPL9 protein network | https://string-db.org/network/9606.ENSP00000357823 | Mitochondrial ribosomal protein L9 |
| METTL10 protein network | https://string-db.org/network/9606.ENSP00000357829 | EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318' |
| LHPP protein network | https://string-db.org/network/9606.ENSP00000357835 | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can [...] |
| SNX27 protein network | https://string-db.org/network/9606.ENSP00000357836 | Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following intern [...] |
| OAT protein network | https://string-db.org/network/9606.ENSP00000357838 | Ornithine aminotransferase, mitochondrial; Ornithine aminotransferase |
| KIAA1919 protein network | https://string-db.org/network/9606.ENSP00000357840 | Sodium-dependent glucose transporter 1; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney |
| TUFT1 protein network | https://string-db.org/network/9606.ENSP00000357842 | Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family |
| SLC16A10 protein network | https://string-db.org/network/9606.ENSP00000357844 | Monocarboxylate transporter 10; Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epith [...] |
| BUB3 protein network | https://string-db.org/network/9606.ENSP00000357858 | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes th [...] |
| GTF3C6 protein network | https://string-db.org/network/9606.ENSP00000357863 | General transcription factor 3C polypeptide 6; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...] |
| PI4KB protein network | https://string-db.org/network/9606.ENSP00000357869 | Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regula [...] |
| ACADSB protein network | https://string-db.org/network/9606.ENSP00000357873 | Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl- CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- [...] |
| PSMD4 protein network | https://string-db.org/network/9606.ENSP00000357879 | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a k [...] |
| AMD1 protein network | https://string-db.org/network/9606.ENSP00000357880 | S-adenosylmethionine decarboxylase proenzyme; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining s [...] |
| IKZF5 protein network | https://string-db.org/network/9606.ENSP00000357881 | Zinc finger protein Pegasus; DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor; Zinc fingers C2H2-type |
| PSTK protein network | https://string-db.org/network/9606.ENSP00000357882 | L-seryl-tRNA(Sec) kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis |
| PIP5K1A protein network | https://string-db.org/network/9606.ENSP00000357883 | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) [...] |
| FAM24A protein network | https://string-db.org/network/9606.ENSP00000357889 | Protein FAM24A; Family with sequence similarity 24 member A |
| FAM24B protein network | https://string-db.org/network/9606.ENSP00000357894 | Protein FAM24B; Family with sequence similarity 24 member B |
| CUZD1 protein network | https://string-db.org/network/9606.ENSP00000357900 | CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a [...] |
| SCNM1 protein network | https://string-db.org/network/9606.ENSP00000357901 | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites |
| LYSMD1 protein network | https://string-db.org/network/9606.ENSP00000357904 | LysM and putative peptidoglycan-binding domain-containing protein 1; LysM domain containing 1 |
| DMBT1 protein network | https://string-db.org/network/9606.ENSP00000357905 | Deleted in malignant brain tumors 1 protein; May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense [...] |
| TNFAIP8L2 protein network | https://string-db.org/network/9606.ENSP00000357906 | Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like recep [...] |
| CDK19 protein network | https://string-db.org/network/9606.ENSP00000357907 | Cyclin dependent kinase 19; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily |
| SEMA6C protein network | https://string-db.org/network/9606.ENSP00000357909 | Semaphorin-6C; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other ne [...] |
| GABPB2 protein network | https://string-db.org/network/9606.ENSP00000357914 | GA-binding protein subunit beta-2; May function as transcription factor capable of interacting with purine rich repeats (GA repeats); Ankyrin repeat domain containing |
| SLC22A16 protein network | https://string-db.org/network/9606.ENSP00000357915 | Solute carrier family 22 member 16; High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididyma [...] |
| MLLT11 protein network | https://string-db.org/network/9606.ENSP00000357917 | Protein AF1q; Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate; Belongs to th [...] |
| DDO protein network | https://string-db.org/network/9606.ENSP00000357920 | D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate |
| C1orf56 protein network | https://string-db.org/network/9606.ENSP00000357922 | Protein MENT; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B |
| BNIPL protein network | https://string-db.org/network/9606.ENSP00000357927 | Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein; May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death; BCH domain containing |
| CDC40 protein network | https://string-db.org/network/9606.ENSP00000357928 | Pre-mRNA-processing factor 17; Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing; Spliceosomal Bact complex |
| ANXA9 protein network | https://string-db.org/network/9606.ENSP00000357943 | Annexin A9; Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes; Belongs to the annexin family |
| LACE1 protein network | https://string-db.org/network/9606.ENSP00000357973 | AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits [...] |
| NR2E1 protein network | https://string-db.org/network/9606.ENSP00000357979 | Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' i [...] |
| HTRA1 protein network | https://string-db.org/network/9606.ENSP00000357980 | Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells [...] |
| CTSS protein network | https://string-db.org/network/9606.ENSP00000357981 | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specif [...] |
| PLEKHA1 protein network | https://string-db.org/network/9606.ENSP00000357986 | Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins [...] |
| SEC63 protein network | https://string-db.org/network/9606.ENSP00000357998 | Translocation protein SEC63 homolog; Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane; DNAJ heat shock proteins |
| TACC2 protein network | https://string-db.org/network/9606.ENSP00000358001 | Transforming acidic coiled-coil-containing protein 2; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-medi [...] |
| SCML4 protein network | https://string-db.org/network/9606.ENSP00000358016 | Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...] |
| NSMCE4A protein network | https://string-db.org/network/9606.ENSP00000358019 | Non-structural maintenance of chromosomes element 4 homolog A; Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may prom [...] |
| MCL1 protein network | https://string-db.org/network/9606.ENSP00000358022 | Induced myeloid leukemia cell differentiation protein Mcl-1; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates i [...] |
| PDSS2 protein network | https://string-db.org/network/9606.ENSP00000358033 | Decaprenyl-diphosphate synthase subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10 |
| ADAMTSL4 protein network | https://string-db.org/network/9606.ENSP00000358035 | ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis; ADAMTS like |
| QRSL1 protein network | https://string-db.org/network/9606.ENSP00000358042 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...] |
| ECM1 protein network | https://string-db.org/network/9606.ENSP00000358045 | Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. [...] |
| RTN4IP1 protein network | https://string-db.org/network/9606.ENSP00000358059 | Reticulon-4-interacting protein 1, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve [...] |
| TARS2 protein network | https://string-db.org/network/9606.ENSP00000358060 | Threonine--tRNA ligase, mitochondrial; Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the a [...] |
| AIM1 protein network | https://string-db.org/network/9606.ENSP00000358062 | Beta/gamma crystallin domain-containing protein 1; May function as suppressor of malignant melanoma. It may exert its effects through interactions with the cytoskeleton |
| RPRD2 protein network | https://string-db.org/network/9606.ENSP00000358064 | Regulation of nuclear pre-mRNA domain containing 2 |
| SEC23IP protein network | https://string-db.org/network/9606.ENSP00000358071 | SEC23-interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate [...] |
| ATG5 protein network | https://string-db.org/network/9606.ENSP00000358072 | Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E [...] |
| BAG3 protein network | https://string-db.org/network/9606.ENSP00000358081 | BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...] |
| TIAL1 protein network | https://string-db.org/network/9606.ENSP00000358089 | Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis |
| PRDM1 protein network | https://string-db.org/network/9606.ENSP00000358092 | PR domain zinc finger protein 1; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident [...] |
| C1orf54 protein network | https://string-db.org/network/9606.ENSP00000358098 | Uncharacterized protein C1orf54; Chromosome 1 open reading frame 54 |
| RGS10 protein network | https://string-db.org/network/9606.ENSP00000358099 | Regulator of G-protein signaling 10; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transd [...] |
| APH1A protein network | https://string-db.org/network/9606.ENSP00000358105 | Gamma-secretase subunit APH-1A; Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch [...] |
| PREP protein network | https://string-db.org/network/9606.ENSP00000358106 | Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long; Belongs to the peptidase S9A family |
| CA14 protein network | https://string-db.org/network/9606.ENSP00000358107 | Carbonic anhydrase 14; Reversible hydration of carbon dioxide; Carbonic anhydrases |
| PLEKHO1 protein network | https://string-db.org/network/9606.ENSP00000358120 | Pleckstrin homology domain-containing family O member 1; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target [...] |
| VPS45 protein network | https://string-db.org/network/9606.ENSP00000358126 | Vacuolar protein sorting-associated protein 45; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network |
| EIF3A protein network | https://string-db.org/network/9606.ENSP00000358140 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiatio [...] |
| SV2A protein network | https://string-db.org/network/9606.ENSP00000358142 | Synaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates ves [...] |
| CACUL1 protein network | https://string-db.org/network/9606.ENSP00000358147 | CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition |
| BOLA1 protein network | https://string-db.org/network/9606.ENSP00000358149 | BolA-like protein 1; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably [...] |
| HIST2H2BE protein network | https://string-db.org/network/9606.ENSP00000358151 | Histone H2B type 2-E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| HIST2H3C protein network | https://string-db.org/network/9606.ENSP00000358154 | Histone cluster 2 H3 family member c; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| HIST2H2AA protein network | https://string-db.org/network/9606.ENSP00000358155 | Histone cluster 2 H2A family member a4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as [...] |
| ASCC3 protein network | https://string-db.org/network/9606.ENSP00000358159 | Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enablin [...] |
| HIST1H3H protein network | https://string-db.org/network/9606.ENSP00000358160 | Histone cluster 1 H3 family member h; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| FCGR1A protein network | https://string-db.org/network/9606.ENSP00000358165 | High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses; Belongs to the immunog [...] |
| FAM204A protein network | https://string-db.org/network/9606.ENSP00000358183 | Protein FAM204A; Family with sequence similarity 204 member A |
| VAX1 protein network | https://string-db.org/network/9606.ENSP00000358207 | Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrai [...] |
| SIM1 protein network | https://string-db.org/network/9606.ENSP00000358210 | Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult; Basic helix-loop-helix proteins |
| HSPA12A protein network | https://string-db.org/network/9606.ENSP00000358211 | Heat shock protein family A member 12A |
| C10orf82 protein network | https://string-db.org/network/9606.ENSP00000358212 | Uncharacterized protein C10orf82; Chromosome 10 open reading frame 82 |
| PRDM13 protein network | https://string-db.org/network/9606.ENSP00000358217 | PR domain zinc finger protein 13; May be involved in transcriptional regulation; PR/SET domain family |
| PNLIP protein network | https://string-db.org/network/9606.ENSP00000358223 | Pancreatic lipase; Belongs to the AB hydrolase superfamily. Lipase family |
| PNLIPRP3 protein network | https://string-db.org/network/9606.ENSP00000358232 | Pancreatic lipase related protein 3; Lipases |
| GPR89B protein network | https://string-db.org/network/9606.ENSP00000358233 | annotation not available |
| GJA8 protein network | https://string-db.org/network/9606.ENSP00000358238 | Gap junction alpha-8 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| PNISR protein network | https://string-db.org/network/9606.ENSP00000358242 | Arginine/serine-rich protein PNISR; PNN interacting serine and arginine rich protein; Belongs to the splicing factor SR family |
| FBXL4 protein network | https://string-db.org/network/9606.ENSP00000358247 | F-box and leucine rich repeat protein 4 |
| FAM160B1 protein network | https://string-db.org/network/9606.ENSP00000358251 | Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing |
| CHD1L protein network | https://string-db.org/network/9606.ENSP00000358262 | Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-r [...] |
| KLHL32 protein network | https://string-db.org/network/9606.ENSP00000358265 | Kelch-like protein 32; Kelch like family member 32; BTB domain containing |
| NDUFAF4 protein network | https://string-db.org/network/9606.ENSP00000358272 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). May be involved in cell prolife [...] |
| UFL1 protein network | https://string-db.org/network/9606.ENSP00000358283 | E3 UFM1-protein ligase 1; E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysin [...] |
| CCDC186 protein network | https://string-db.org/network/9606.ENSP00000358293 | Coiled-coil domain containing 186 |
| ADRB1 protein network | https://string-db.org/network/9606.ENSP00000358301 | Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and nore [...] |
| NHLRC2 protein network | https://string-db.org/network/9606.ENSP00000358307 | Required for normal embryonic development. |
| EPHA7 protein network | https://string-db.org/network/9606.ENSP00000358309 | Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| ITGA10 protein network | https://string-db.org/network/9606.ENSP00000358310 | Integrin alpha-10; Integrin alpha-10/beta-1 is a receptor for collagen; Belongs to the integrin alpha chain family |
| PEX11B protein network | https://string-db.org/network/9606.ENSP00000358312 | Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes memb [...] |
| PLEKHS1 protein network | https://string-db.org/network/9606.ENSP00000358316 | Pleckstrin homology domain containing S1 |
| POLR3GL protein network | https://string-db.org/network/9606.ENSP00000358320 | DNA-directed RNA polymerase III subunit RPC7-like; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific per [...] |
| CASP7 protein network | https://string-db.org/network/9606.ENSP00000358327 | Caspase-7; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves p [...] |
| MAP3K7 protein network | https://string-db.org/network/9606.ENSP00000358335 | Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...] |
| GJA10 protein network | https://string-db.org/network/9606.ENSP00000358358 | Gap junction alpha-10 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to [...] |
| PDE4DIP protein network | https://string-db.org/network/9606.ENSP00000358363 | Myomegalin; Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Forms a complex with AKAP9: the complex recruits CAMSAP2 to t [...] |
| NRAP protein network | https://string-db.org/network/9606.ENSP00000358365 | Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular [...] |
| SCAF11 protein network | https://string-db.org/network/9606.ENSP00000358374 | Protein SCAF11; Plays a role in pre-mRNA alternative splicing by regulating spliceosome assembly; Ring finger proteins |
| FCGR1B protein network | https://string-db.org/network/9606.ENSP00000358391 | High affinity immunoglobulin gamma Fc receptor IB; May bind to the Fc region of immunoglobulins gamma with a low affinity compared to FCGR1A. May function in the humoral immune response |
| FAM72B protein network | https://string-db.org/network/9606.ENSP00000358397 | Protein FAM72B; Family with sequence similarity 72 member B; Belongs to the FAM72 family |
| MDN1 protein network | https://string-db.org/network/9606.ENSP00000358400 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition poi [...] |
| TCF7L2 protein network | https://string-db.org/network/9606.ENSP00000358404 | Transcription factor 7-like 2; Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of [...] |
| ADAM30 protein network | https://string-db.org/network/9606.ENSP00000358407 | Disintegrin and metalloproteinase domain-containing protein 30; Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP [...] |
| ZDHHC6 protein network | https://string-db.org/network/9606.ENSP00000358413 | Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is r [...] |
| HMGCS2 protein network | https://string-db.org/network/9606.ENSP00000358414 | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase |
| PHGDH protein network | https://string-db.org/network/9606.ENSP00000358417 | D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D- glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Als [...] |
| HSD3B1 protein network | https://string-db.org/network/9606.ENSP00000358421 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxid [...] |
| RRAGD protein network | https://string-db.org/network/9606.ENSP00000358423 | Ras-related GTP-binding protein D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its sub [...] |
| TECTB protein network | https://string-db.org/network/9606.ENSP00000358430 | Beta-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepith [...] |
| GDAP2 protein network | https://string-db.org/network/9606.ENSP00000358451 | Ganglioside induced differentiation associated protein 2; Belongs to the GDAP2 family |
| FAM46C protein network | https://string-db.org/network/9606.ENSP00000358458 | Putative nucleotidyltransferase FAM46C; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase; Belongs to the FAM46 family |
| CLIC2 protein network | https://string-db.org/network/9606.ENSP00000358460 | Chloride intracellular channel protein 2; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occu [...] |
| SHOC2 protein network | https://string-db.org/network/9606.ENSP00000358464 | Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, [...] |
| RAB39B protein network | https://string-db.org/network/9606.ENSP00000358466 | Ras-related protein Rab-39B; Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to t [...] |
| VTCN1 protein network | https://string-db.org/network/9606.ENSP00000358470 | V-set domain-containing T-cell activation inhibitor 1; Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of [...] |
| BRCC3 protein network | https://string-db.org/network/9606.ENSP00000358474 | Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Compone [...] |
| TTF2 protein network | https://string-db.org/network/9606.ENSP00000358478 | Transcription termination factor 2; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May [...] |
| CD101 protein network | https://string-db.org/network/9606.ENSP00000358482 | Immunoglobulin superfamily member 2; Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine k [...] |
| MTCP1 protein network | https://string-db.org/network/9606.ENSP00000358488 | Protein p13 MTCP-1; Enhances the phosphorylation and activation of AKT1 and AKT2 |
| CD2 protein network | https://string-db.org/network/9606.ENSP00000358490 | T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the trig [...] |
| C1orf137 protein network | https://string-db.org/network/9606.ENSP00000358494 | Putative uncharacterized protein C1orf137; Chromosome 1 open reading frame 137 |
| IGSF3 protein network | https://string-db.org/network/9606.ENSP00000358495 | Immunoglobulin superfamily member 3; Immunoglobulin like domain containing |
| CMC4 protein network | https://string-db.org/network/9606.ENSP00000358496 | Cx9C motif-containing protein 4; C-X9-C motif containing 4 |
| RNGTT protein network | https://string-db.org/network/9606.ENSP00000358497 | mRNA-capping enzyme; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the [...] |
| CD58 protein network | https://string-db.org/network/9606.ENSP00000358501 | Lymphocyte function-associated antigen 3; Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-inde [...] |
| FUNDC2 protein network | https://string-db.org/network/9606.ENSP00000358510 | FUN14 domain containing 2; Belongs to the FUN14 family |
| MAB21L3 protein network | https://string-db.org/network/9606.ENSP00000358512 | Protein mab-21-like 3; Mab-21 like 3 |
| CNR1 protein network | https://string-db.org/network/9606.ENSP00000358513 | Cannabinoid receptor 1; G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as w [...] |
| SLC22A15 protein network | https://string-db.org/network/9606.ENSP00000358515 | Solute carrier family 22 member 15; Probably transports organic cations (By similarity). Appears not to be the agmatine transporter; Solute carriers |
| F8A2 protein network | https://string-db.org/network/9606.ENSP00000358518 | Coagulation factor VIII-associated 2; Not known. Possible housekeeping role |
| NHLH2 protein network | https://string-db.org/network/9606.ENSP00000358519 | Helix-loop-helix protein 2; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system; Basic helix-loop-helix p [...] |
| NGF protein network | https://string-db.org/network/9606.ENSP00000358525 | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptor [...] |
| TSPAN2 protein network | https://string-db.org/network/9606.ENSP00000358529 | Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature she [...] |
| RBM20 protein network | https://string-db.org/network/9606.ENSP00000358532 | RNA-binding protein 20; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin) |
| SYCP1 protein network | https://string-db.org/network/9606.ENSP00000358535 | Synaptonemal complex protein 1; Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for normal ass [...] |
| SIKE1 protein network | https://string-db.org/network/9606.ENSP00000358541 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated [...] |
| MPP1 protein network | https://string-db.org/network/9606.ENSP00000358547 | 55 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PI [...] |
| NRAS protein network | https://string-db.org/network/9606.ENSP00000358548 | GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity |
| RARS2 protein network | https://string-db.org/network/9606.ENSP00000358549 | Probable arginine--tRNA ligase, mitochondrial; arginyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I |
| BCAS2 protein network | https://string-db.org/network/9606.ENSP00000358554 | Pre-mRNA-splicing factor SPF27; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role i [...] |
| DKC1 protein network | https://string-db.org/network/9606.ENSP00000358563 | H/ACA ribonucleoprotein complex subunit 4; Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRN [...] |
| SLC35A1 protein network | https://string-db.org/network/9606.ENSP00000358565 | CMP-sialic acid transporter; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function; Belongs to the nucleotide-sugar transporter family. SLC35A subfam [...] |
| HIPK1 protein network | https://string-db.org/network/9606.ENSP00000358571 | Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain t [...] |
| C6orf165 protein network | https://string-db.org/network/9606.ENSP00000358575 | May regulate cilium motility through its role in the assembly of the axonemal radial spokes |
| DCLRE1B protein network | https://string-db.org/network/9606.ENSP00000358576 | 5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-jo [...] |
| AP4B1 protein network | https://string-db.org/network/9606.ENSP00000358582 | AP-4 complex subunit beta-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They [...] |
| ZNF292 protein network | https://string-db.org/network/9606.ENSP00000358590 | Zinc finger protein 292; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DUSP5 protein network | https://string-db.org/network/9606.ENSP00000358596 | Dual specificity protein phosphatase 5; Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK [...] |
| SMNDC1 protein network | https://string-db.org/network/9606.ENSP00000358616 | Survival of motor neuron-related-splicing factor 30; Necessary for spliceosome assembly. Overexpression causes apoptosis; Belongs to the SMN family |
| PHTF1 protein network | https://string-db.org/network/9606.ENSP00000358617 | Putative homeodomain transcription factor 1; May play a role in transcription regulation |
| SYNCRIP protein network | https://string-db.org/network/9606.ENSP00000358635 | Heterogeneous nuclear ribonucleoprotein Q; Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD- mediated complex that promotes MYC mRNA s [...] |
| FAM19A3 protein network | https://string-db.org/network/9606.ENSP00000358644 | Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family |
| UBL4A protein network | https://string-db.org/network/9606.ENSP00000358674 | Ubiquitin-like protein 4A; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and pa [...] |
| TBX18 protein network | https://string-db.org/network/9606.ENSP00000358677 | T-box transcription factor TBX18; Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart and coronary vessels, the ureter an [...] |
| CYB5R4 protein network | https://string-db.org/network/9606.ENSP00000358695 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress [...] |
| PLXNA3 protein network | https://string-db.org/network/9606.ENSP00000358696 | Plexin-A3; Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous [...] |
| WNT2B protein network | https://string-db.org/network/9606.ENSP00000358698 | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| RIPPLY2 protein network | https://string-db.org/network/9606.ENSP00000358703 | Protein ripply2; Plays a role in somitogenesis. Required for somite segregation and establishment of rostrocaudal polarity in somites (By similarity) |
| PRSS35 protein network | https://string-db.org/network/9606.ENSP00000358714 | Belongs to the peptidase S1 family |
| SORCS3 protein network | https://string-db.org/network/9606.ENSP00000358715 | Sortilin related VPS10 domain containing receptor 3; Belongs to the VPS10-related sortilin family. SORCS subfamily |
| DDX20 protein network | https://string-db.org/network/9606.ENSP00000358716 | Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, pla [...] |
| CFAP58 protein network | https://string-db.org/network/9606.ENSP00000358718 | Cilia and flagella associated protein 58; Belongs to the CFAP58 family |
| ME1 protein network | https://string-db.org/network/9606.ENSP00000358719 | Malic enzyme 1 |
| RAP1A protein network | https://string-db.org/network/9606.ENSP00000358723 | Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with R [...] |
| GSTO1 protein network | https://string-db.org/network/9606.ENSP00000358727 | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione [...] |
| ADORA3 protein network | https://string-db.org/network/9606.ENSP00000358730 | Transmembrane domain-containing protein TMIGD3; Isoform 1: Plays a suppressive role in osteosarcoma malignancy by inhibiting NF-kappa-B activity; Adenosine receptors |
| ATP5F1 protein network | https://string-db.org/network/9606.ENSP00000358737 | ATP synthase F(0) complex subunit B1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...] |
| RWDD2A protein network | https://string-db.org/network/9606.ENSP00000358739 | RWD domain containing 2A |
| SFR1 protein network | https://string-db.org/network/9606.ENSP00000358742 | Swi5-dependent recombination DNA repair protein 1 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcript [...] |
| OVGP1 protein network | https://string-db.org/network/9606.ENSP00000358747 | Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development; Chitinases |
| PIFO protein network | https://string-db.org/network/9606.ENSP00000358753 | Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/c [...] |
| CHIA protein network | https://string-db.org/network/9606.ENSP00000358755 | Acidic mammalian chitinase; Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune respons [...] |
| UBE3D protein network | https://string-db.org/network/9606.ENSP00000358762 | E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degr [...] |
| TPBG protein network | https://string-db.org/network/9606.ENSP00000358765 | Trophoblast glycoprotein; May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a- dependent LRP6 internalization |
| SLK protein network | https://string-db.org/network/9606.ENSP00000358770 | STE20-like serine/threonine-protein kinase; Mediates apoptosis and actin stress fiber dissolution; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily |
| ATP6AP1 protein network | https://string-db.org/network/9606.ENSP00000358777 | V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-typ [...] |
| LRIF1 protein network | https://string-db.org/network/9606.ENSP00000358778 | Ligand-dependent nuclear receptor-interacting factor 1; Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recr [...] |
| NPBWR2 protein network | https://string-db.org/network/9606.ENSP00000358783 | Neuropeptides B/W receptor type 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food inta [...] |
| KCNA3 protein network | https://string-db.org/network/9606.ENSP00000358784 | Potassium voltage-gated channel subfamily A member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...] |
| KCNA10 protein network | https://string-db.org/network/9606.ENSP00000358786 | Potassium voltage-gated channel subfamily A member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the vol [...] |
| SLC16A4 protein network | https://string-db.org/network/9606.ENSP00000358794 | Monocarboxylate transporter 5; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...] |
| NEURL1 protein network | https://string-db.org/network/9606.ENSP00000358795 | E3 ubiquitin-protein ligase NEURL1; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulat [...] |
| CALHM3 protein network | https://string-db.org/network/9606.ENSP00000358798 | Calcium homeostasis modulator protein 3; Pore-forming subunit of a voltage-gated ion channel; Belongs to the CALHM family |
| RBM15 protein network | https://string-db.org/network/9606.ENSP00000358799 | Putative RNA-binding protein 15; May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exp [...] |
| KCNC4 protein network | https://string-db.org/network/9606.ENSP00000358802 | Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in res [...] |
| ALX3 protein network | https://string-db.org/network/9606.ENSP00000358807 | Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; PRD class homeoboxes and pseudogenes |
| STRIP1 protein network | https://string-db.org/network/9606.ENSP00000358810 | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape; STRIPAK complex |
| PDCD11 protein network | https://string-db.org/network/9606.ENSP00000358812 | Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA; Minor his [...] |
| TTK protein network | https://string-db.org/network/9606.ENSP00000358813 | Dual specificity protein kinase TTK; Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB [...] |
| AHCYL1 protein network | https://string-db.org/network/9606.ENSP00000358814 | S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secret [...] |
| NEURL1B protein network | https://string-db.org/network/9606.ENSP00000358815 | E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands; Ring finger p [...] |
| EPS8L3 protein network | https://string-db.org/network/9606.ENSP00000358820 | Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8 like 3 |
| DNASE1L1 protein network | https://string-db.org/network/9606.ENSP00000358824 | Deoxyribonuclease 1 like 1; Belongs to the DNase I family |
| ELOVL4 protein network | https://string-db.org/network/9606.ENSP00000358831 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| USMG5 protein network | https://string-db.org/network/9606.ENSP00000358840 | Up-regulated during skeletal muscle growth protein 5; Plays a critical role in maintaining the ATP synthase population in mitochondria |
| GSTM4 protein network | https://string-db.org/network/9606.ENSP00000358851 | Glutathione S-transferase Mu 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene; Soluble glutathi [...] |
| SH3BGRL2 protein network | https://string-db.org/network/9606.ENSP00000358853 | SH3 domain binding glutamate rich protein like 2; Belongs to the SH3BGR family |
| TAF5 protein network | https://string-db.org/network/9606.ENSP00000358854 | Transcription initiation factor TFIID subunit 5; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs compon [...] |
| EMD protein network | https://string-db.org/network/9606.ENSP00000358857 | Emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibi [...] |
| PCGF6 protein network | https://string-db.org/network/9606.ENSP00000358862 | Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprote [...] |
| INA protein network | https://string-db.org/network/9606.ENSP00000358865 | Alpha-internexin; Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the [...] |
| FLNA protein network | https://string-db.org/network/9606.ENSP00000358866 | Filamin-A; Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a s [...] |
| GNAI3 protein network | https://string-db.org/network/9606.ENSP00000358867 | Guanine nucleotide-binding protein G(k) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in [...] |
| AMIGO1 protein network | https://string-db.org/network/9606.ENSP00000358880 | Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. [...] |
| CYB561D1 protein network | https://string-db.org/network/9606.ENSP00000358884 | Cytochrome b561 family member D1 |
| ATXN7L2 protein network | https://string-db.org/network/9606.ENSP00000358886 | Ataxin-7-like protein 2; Ataxin 7 like 2 |
| SYPL2 protein network | https://string-db.org/network/9606.ENSP00000358888 | Synaptophysin-like protein 2; Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes; Synaptophysins |
| CNNM2 protein network | https://string-db.org/network/9606.ENSP00000358894 | Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity [...] |
| AS3MT protein network | https://string-db.org/network/9606.ENSP00000358896 | Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylars [...] |
| SAMD10 protein network | https://string-db.org/network/9606.ENSP00000358902 | Sterile alpha motif domain containing 10 |
| CYP17A1 protein network | https://string-db.org/network/9606.ENSP00000358903 | Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedion [...] |
| SFXN2 protein network | https://string-db.org/network/9606.ENSP00000358909 | Sideroflexin-2; Potential iron transporter; Sideroflexins |
| SUFU protein network | https://string-db.org/network/9606.ENSP00000358918 | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Down- regulates GLI2-mediated transactivation of t [...] |
| ACTR1A protein network | https://string-db.org/network/9606.ENSP00000358921 | Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome; Actin related proteins |
| PSRC1 protein network | https://string-db.org/network/9606.ENSP00000358925 | Proline/serine-rich coiled-coil protein 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal [...] |
| TKTL1 protein network | https://string-db.org/network/9606.ENSP00000358931 | Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate |
| ABHD16B protein network | https://string-db.org/network/9606.ENSP00000358932 | Protein ABHD16B; Abhydrolase domain containing 16B; Belongs to the AB hydrolase superfamily. ABHD16 family |
| OPN1MW2 protein network | https://string-db.org/network/9606.ENSP00000358945 | Opsin 1 (cone pigments), medium-wave-sensitive 2; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal |
| CUEDC2 protein network | https://string-db.org/network/9606.ENSP00000358953 | CUE domain-containing protein 2; Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estrad [...] |
| KIAA1324 protein network | https://string-db.org/network/9606.ENSP00000358955 | UPF0577 protein KIAA1324; May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway |
| IRAK1BP1 protein network | https://string-db.org/network/9606.ENSP00000358956 | Interleukin-1 receptor-associated kinase 1-binding protein 1; Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Ac [...] |
| HTR1B protein network | https://string-db.org/network/9606.ENSP00000358963 | 5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant [...] |
| C1orf194 protein network | https://string-db.org/network/9606.ENSP00000358965 | Uncharacterized protein C1orf194; Chromosome 1 open reading frame 194 |
| IMPG1 protein network | https://string-db.org/network/9606.ENSP00000358966 | Interphotoreceptor matrix proteoglycan 1; May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix |
| OPN1LW protein network | https://string-db.org/network/9606.ENSP00000358967 | Long-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal |
| NFKB2 protein network | https://string-db.org/network/9606.ENSP00000358983 | Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are in [...] |
| MYO6 protein network | https://string-db.org/network/9606.ENSP00000358994 | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that [...] |
| IRAK1 protein network | https://string-db.org/network/9606.ENSP00000358997 | Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like recept [...] |
| TMEM187 protein network | https://string-db.org/network/9606.ENSP00000358999 | Transmembrane protein 187 |
| GBF1 protein network | https://string-db.org/network/9606.ENSP00000359000 | Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the [...] |
| TNFRSF6B protein network | https://string-db.org/network/9606.ENSP00000359013 | Tumor necrosis factor receptor superfamily, member 6b, decoy; Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis; Tumor nec [...] |
| AKNAD1 protein network | https://string-db.org/network/9606.ENSP00000359018 | Protein AKNAD1; AKNA domain containing 1 |
| PITX3 protein network | https://string-db.org/network/9606.ENSP00000359019 | Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its [...] |
| ELOVL3 protein network | https://string-db.org/network/9606.ENSP00000359022 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| STXBP3 protein network | https://string-db.org/network/9606.ENSP00000359025 | Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell sur [...] |
| FNDC7 protein network | https://string-db.org/network/9606.ENSP00000359034 | Fibronectin type III domain containing 7 |
| PRPF38B protein network | https://string-db.org/network/9606.ENSP00000359042 | Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing |
| ARHGAP4 protein network | https://string-db.org/network/9606.ENSP00000359045 | Rho GTPase-activating protein 4; Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells; F-BAR domain containing |
| HENMT1 protein network | https://string-db.org/network/9606.ENSP00000359049 | Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism [...] |
| C10orf76 protein network | https://string-db.org/network/9606.ENSP00000359050 | UPF0668 protein C10orf76; Chromosome 10 open reading frame 76 |
| FAM102B protein network | https://string-db.org/network/9606.ENSP00000359052 | Protein FAM102B; Family with sequence similarity 102 member B; NT-C2 domain containing |
| STMN3 protein network | https://string-db.org/network/9606.ENSP00000359070 | Stathmin-3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3; Stathmins |
| VAV3 protein network | https://string-db.org/network/9606.ENSP00000359073 | Guanine nucleotide exchange factor VAV3; Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays [...] |
| L1CAM protein network | https://string-db.org/network/9606.ENSP00000359077 | Neural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain [...] |
| NTNG1 protein network | https://string-db.org/network/9606.ENSP00000359085 | Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Net [...] |
| PRMT6 protein network | https://string-db.org/network/9606.ENSP00000359095 | Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong [...] |
| AMY1C protein network | https://string-db.org/network/9606.ENSP00000359096 | Amylase, alpha 1C |
| COX7A2 protein network | https://string-db.org/network/9606.ENSP00000359098 | Cytochrome c oxidase subunit 7A2, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| AMY1A protein network | https://string-db.org/network/9606.ENSP00000359100 | Amylase, alpha 1A |
| COL11A1 protein network | https://string-db.org/network/9606.ENSP00000359114 | Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens |
| SRPK3 protein network | https://string-db.org/network/9606.ENSP00000359119 | SRSF protein kinase 3; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, know [...] |
| DPH5 protein network | https://string-db.org/network/9606.ENSP00000359127 | Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 ( [...] |
| NPM3 protein network | https://string-db.org/network/9606.ENSP00000359128 | Nucleoplasmin-3; May act as a chaperone |
| SLC30A7 protein network | https://string-db.org/network/9606.ENSP00000359130 | Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc- requ [...] |
| EXTL2 protein network | https://string-db.org/network/9606.ENSP00000359132 | Exostosin-like 2; Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked [...] |
| FBXW4 protein network | https://string-db.org/network/9606.ENSP00000359149 | F-box/WD repeat-containing protein 4; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathw [...] |
| DBT protein network | https://string-db.org/network/9606.ENSP00000359151 | Dihydrolipoamide branched chain transacylase E2; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multip [...] |
| TRMT13 protein network | https://string-db.org/network/9606.ENSP00000359160 | tRNA:m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His) |
| DPCD protein network | https://string-db.org/network/9606.ENSP00000359170 | Protein DPCD; May play a role in the formation or function of ciliated cells |
| HIAT1 protein network | https://string-db.org/network/9606.ENSP00000359171 | Hippocampus abundant transcript 1 |
| SLC35A3 protein network | https://string-db.org/network/9606.ENSP00000359172 | UDP-N-acetylglucosamine transporter; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransfe [...] |
| POLL protein network | https://string-db.org/network/9606.ENSP00000359181 | DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) site [...] |
| PPDPF protein network | https://string-db.org/network/9606.ENSP00000359198 | Pancreatic progenitor cell differentiation and proliferation factor; Probable regulator of exocrine pancreas development |
| LPPR4 protein network | https://string-db.org/network/9606.ENSP00000359204 | Phospholipid phosphatase-related protein type 4; Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts a [...] |
| BTRC protein network | https://string-db.org/network/9606.ENSP00000359206 | F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent pro [...] |
| DPYD protein network | https://string-db.org/network/9606.ENSP00000359211 | Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-flu [...] |
| LBX1 protein network | https://string-db.org/network/9606.ENSP00000359212 | Transcription factor LBX1; Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial musc [...] |
| TLX1 protein network | https://string-db.org/network/9606.ENSP00000359215 | T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'; NKL subclass homeoboxes and pseudogenes |
| PTBP2 protein network | https://string-db.org/network/9606.ENSP00000359216 | Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific m [...] |
| KAZALD1 protein network | https://string-db.org/network/9606.ENSP00000359219 | Kazal-type serine protease inhibitor domain-containing protein 1; Involved in the proliferation of osteoblasts during bone formation and bone regeneration. Promotes matrix assembly (By similarity [...] |
| RWDD3 protein network | https://string-db.org/network/9606.ENSP00000359221 | RWD domain-containing protein 3; Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester [...] |
| TMEM56 protein network | https://string-db.org/network/9606.ENSP00000359222 | Transmembrane protein 56; TLC domain containing |
| ALG14 protein network | https://string-db.org/network/9606.ENSP00000359224 | UDP-N-acetylglucosamine transferase subunit ALG14 homolog; May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May ancho [...] |
| CNN3 protein network | https://string-db.org/network/9606.ENSP00000359225 | Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropom [...] |
| HAUS7 protein network | https://string-db.org/network/9606.ENSP00000359230 | HAUS augmin-like complex subunit 7; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to [...] |
| ABCD3 protein network | https://string-db.org/network/9606.ENSP00000359233 | ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial s [...] |
| LZTS2 protein network | https://string-db.org/network/9606.ENSP00000359240 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion [...] |
| ABCA4 protein network | https://string-db.org/network/9606.ENSP00000359245 | Retinal-specific ATP-binding cassette transporter; In the visual cycle, acts as an inward-directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (r [...] |
| GCLM protein network | https://string-db.org/network/9606.ENSP00000359258 | Glutamate-cysteine ligase modifier subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily |
| BCAR3 protein network | https://string-db.org/network/9606.ENSP00000359264 | Breast cancer anti-estrogen resistance protein 3; May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast canc [...] |
| ZNF275 protein network | https://string-db.org/network/9606.ENSP00000359271 | Zinc finger protein 275; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CHRNA4 protein network | https://string-db.org/network/9606.ENSP00000359285 | Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| FAM178A protein network | https://string-db.org/network/9606.ENSP00000359292 | SMC5-SMC6 complex localization factor protein 2; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. Th [...] |
| DR1 protein network | https://string-db.org/network/9606.ENSP00000359295 | Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the f [...] |
| NSDHL protein network | https://string-db.org/network/9606.ENSP00000359297 | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis; Short chain dehydrogenase/reduc [...] |
| CETN2 protein network | https://string-db.org/network/9606.ENSP00000359300 | Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis [...] |
| TMED5 protein network | https://string-db.org/network/9606.ENSP00000359305 | Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; invol [...] |
| CSAG1 protein network | https://string-db.org/network/9606.ENSP00000359310 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1 |
| PAX2 protein network | https://string-db.org/network/9606.ENSP00000359319 | Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS; PRD clas [...] |
| MTF2 protein network | https://string-db.org/network/9606.ENSP00000359321 | Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding [...] |
| FAM69A protein network | https://string-db.org/network/9606.ENSP00000359333 | Protein FAM69A; Family with sequence similarity 69 member A |
| GABRA3 protein network | https://string-db.org/network/9606.ENSP00000359337 | Gamma-aminobutyric acid receptor subunit alpha-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| MB21D1 protein network | https://string-db.org/network/9606.ENSP00000359339 | Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at [...] |
| NKAIN4 protein network | https://string-db.org/network/9606.ENSP00000359340 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4; Sodium/potassium transporting ATPase interacting 4; Belongs to the NKAIN family |
| RPL5 protein network | https://string-db.org/network/9606.ENSP00000359345 | 60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNA [...] |
| GABRE protein network | https://string-db.org/network/9606.ENSP00000359353 | Gamma-aminobutyric acid receptor subunit epsilon; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| EVI5 protein network | https://string-db.org/network/9606.ENSP00000359356 | Ecotropic viral integration site 5 protein homolog; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May [...] |
| GFI1 protein network | https://string-db.org/network/9606.ENSP00000359357 | Zinc finger protein Gfi-1; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region [...] |
| DDX43 protein network | https://string-db.org/network/9606.ENSP00000359361 | Probable ATP-dependent RNA helicase DDX43; DEAD-box helicase 43 |
| YTHDF1 protein network | https://string-db.org/network/9606.ENSP00000359364 | YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at int [...] |
| SEC31B protein network | https://string-db.org/network/9606.ENSP00000359370 | Protein transport protein Sec31B; As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum; Belongs to the WD repeat [...] |
| FATE1 protein network | https://string-db.org/network/9606.ENSP00000359375 | Fetal and adult testis-expressed transcript protein; Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER- mitochondria distance and Ca(2+) [...] |
| SLC17A9 protein network | https://string-db.org/network/9606.ENSP00000359376 | Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and syna [...] |
| PRRG3 protein network | https://string-db.org/network/9606.ENSP00000359378 | Transmembrane gamma-carboxyglutamic acid protein 3; Proline rich and Gla domain containing |
| SCD protein network | https://string-db.org/network/9606.ENSP00000359380 | Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the [...] |
| PASD1 protein network | https://string-db.org/network/9606.ENSP00000359382 | Circadian clock protein PASD1; Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body. Acts as a nuclear repressor of the CLOCK- AR [...] |
| OOEP protein network | https://string-db.org/network/9606.ENSP00000359384 | Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; Belongs to the [...] |
| GLMN protein network | https://string-db.org/network/9606.ENSP00000359385 | Glomulin; Essential for normal development of the vasculature. May represent a naturally occurring ligand of the immunophilins FKBP59 and FKBP12. May function as an membrane anchoring protein. Is [...] |
| KHDC3L protein network | https://string-db.org/network/9606.ENSP00000359392 | KHDC3-like protein; KH domain containing 3 like, subcortical maternal complex member; Belongs to the KHDC1 family |
| HMGB3 protein network | https://string-db.org/network/9606.ENSP00000359393 | High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a [...] |
| DPPA5 protein network | https://string-db.org/network/9606.ENSP00000359396 | Developmental pluripotency-associated 5 protein; Involved in the maintenance of embryonic stem (ES) cell pluripotency. Dispensable for self-renewal of pluripotent ES cells and establishment of ge [...] |
| BLOC1S2 protein network | https://string-db.org/network/9606.ENSP00000359398 | Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| C1orf146 protein network | https://string-db.org/network/9606.ENSP00000359401 | Uncharacterized protein C1orf146; Chromosome 1 open reading frame 146 |
| KIAA1107 protein network | https://string-db.org/network/9606.ENSP00000359404 | Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmis [...] |
| EPHX4 protein network | https://string-db.org/network/9606.ENSP00000359410 | Epoxide hydrolase 4; Abhydrolase domain containing |
| KHDC1 protein network | https://string-db.org/network/9606.ENSP00000359411 | KH homology domain-containing protein 1; KH domain containing 1; Belongs to the KHDC1 family |
| KHDC1L protein network | https://string-db.org/network/9606.ENSP00000359415 | Putative KHDC1-like protein; KH domain containing 1 like; Belongs to the KHDC1 family |
| MTMR1 protein network | https://string-db.org/network/9606.ENSP00000359417 | Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4 [...] |
| MTM1 protein network | https://string-db.org/network/9606.ENSP00000359423 | Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate ph [...] |
| CHUK protein network | https://string-db.org/network/9606.ENSP00000359424 | Inhibitor of nuclear factor kappa-B kinase subunit alpha; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammato [...] |
| CXorf40B protein network | https://string-db.org/network/9606.ENSP00000359434 | Protein CXorf40B; Chromosome X open reading frame 40B |
| HSFX1 protein network | https://string-db.org/network/9606.ENSP00000359444 | Heat shock transcription factor family, X-linked 1 |
| CPN1 protein network | https://string-db.org/network/9606.ENSP00000359446 | Carboxypeptidase N catalytic chain; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into [...] |
| HFM1 protein network | https://string-db.org/network/9606.ENSP00000359454 | Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis; RNA helicases |
| OGFRL1 protein network | https://string-db.org/network/9606.ENSP00000359464 | Opioid growth factor receptor like 1 |
| BARHL2 protein network | https://string-db.org/network/9606.ENSP00000359474 | BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes; NKL subclass homeoboxes and pseudogenes |
| ABCC2 protein network | https://string-db.org/network/9606.ENSP00000359478 | Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter; ATP binding cassette subfamil [...] |
| LRRC8C protein network | https://string-db.org/network/9606.ENSP00000359483 | Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...] |
| SMAP1 protein network | https://string-db.org/network/9606.ENSP00000359484 | Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis (By similarity); ArfGAPs |
| GBP6 protein network | https://string-db.org/network/9606.ENSP00000359485 | Guanylate-binding protein 6; Binds GTP, GDP and GMP |
| GBP5 protein network | https://string-db.org/network/9606.ENSP00000359488 | Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microb [...] |
| AFF2 protein network | https://string-db.org/network/9606.ENSP00000359489 | AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure; AF4/FMR2 family |
| GBP4 protein network | https://string-db.org/network/9606.ENSP00000359490 | Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity) |
| GBP2 protein network | https://string-db.org/network/9606.ENSP00000359497 | Guanylate-binding protein 2; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promote oxidati [...] |
| FMR1NB protein network | https://string-db.org/network/9606.ENSP00000359498 | Fragile X mental retardation 1 neighbor protein; FMR1 neighbor |
| GBP1 protein network | https://string-db.org/network/9606.ENSP00000359504 | Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial pe [...] |
| C6orf57 protein network | https://string-db.org/network/9606.ENSP00000359505 | Succinate dehydrogenase assembly factor 4, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...] |
| FMR1 protein network | https://string-db.org/network/9606.ENSP00000359506 | Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of [...] |
| CUTC protein network | https://string-db.org/network/9606.ENSP00000359507 | Copper homeostasis protein cutC homolog; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit |
| GBP3 protein network | https://string-db.org/network/9606.ENSP00000359512 | Guanylate-binding protein 3; Exhibits antiviral activity against influenza virus; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily |
| MRGBP protein network | https://string-db.org/network/9606.ENSP00000359518 | MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal [...] |
| ENTPD7 protein network | https://string-db.org/network/9606.ENSP00000359520 | Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP |
| SLITRK2 protein network | https://string-db.org/network/9606.ENSP00000359521 | SLIT and NTRK-like protein 2; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Suppresses neurite outgrowth (By similarity) |
| SPANXN1 protein network | https://string-db.org/network/9606.ENSP00000359524 | Sperm protein associated with the nucleus on the X chromosome N1; SPANX family member N1; Belongs to the SPAN-X family |
| SLC25A28 protein network | https://string-db.org/network/9606.ENSP00000359526 | Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered i [...] |
| GTF2B protein network | https://string-db.org/network/9606.ENSP00000359531 | Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II; Belongs to the TFIIB family |
| NTSR1 protein network | https://string-db.org/network/9606.ENSP00000359532 | Neurotensin receptor type 1; G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenge [...] |
| SPANXN3 protein network | https://string-db.org/network/9606.ENSP00000359534 | Sperm protein associated with the nucleus on the X chromosome N3; SPANX family member N3; Belongs to the SPAN-X family |
| GOT1 protein network | https://string-db.org/network/9606.ENSP00000359539 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vert [...] |
| CREG1 protein network | https://string-db.org/network/9606.ENSP00000359540 | Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. [...] |
| SPANXD protein network | https://string-db.org/network/9606.ENSP00000359546 | Sperm protein associated with the nucleus on the X chromosome D; SPANX family member D; Belongs to the SPAN-X family |
| SPANXA2 protein network | https://string-db.org/network/9606.ENSP00000359549 | Belongs to the SPAN-X family |
| SPANXA1 protein network | https://string-db.org/network/9606.ENSP00000359550 | Sperm protein associated with the nucleus, X-linked, family member A1; Belongs to the SPAN-X family |
| PKN2 protein network | https://string-db.org/network/9606.ENSP00000359552 | Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role [...] |
| LDOC1 protein network | https://string-db.org/network/9606.ENSP00000359557 | Protein LDOC1; May have an important role in the development and/or progression of some cancers; Belongs to the LDOC1 family |
| C20orf166 protein network | https://string-db.org/network/9606.ENSP00000359558 | Uncharacterized protein MIR1-1HG; Chromosome 20 open reading frame 166 |
| CDR1 protein network | https://string-db.org/network/9606.ENSP00000359563 | Cerebellar degeneration related protein 1 |
| SOX3 protein network | https://string-db.org/network/9606.ENSP00000359567 | Transcription factor SOX-3; Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferenti [...] |
| CXorf66 protein network | https://string-db.org/network/9606.ENSP00000359571 | Uncharacterized protein CXorf66; Chromosome X open reading frame 66 |
| LMO4 protein network | https://string-db.org/network/9606.ENSP00000359575 | LIM domain transcription factor LMO4; Probable transcriptional factor; LIM domain containing |
| ENSG00000267561 protein network | https://string-db.org/network/9606.ENSP00000359579 | Heparan sulfate 2-O-sulfotransferase 1 |
| HS2ST1 protein network | https://string-db.org/network/9606.ENSP00000359581 | Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, [...] |
| HPSE2 protein network | https://string-db.org/network/9606.ENSP00000359583 | Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) |
| CLCA4 protein network | https://string-db.org/network/9606.ENSP00000359594 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory |
| CLCA2 protein network | https://string-db.org/network/9606.ENSP00000359596 | Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adh [...] |
| ODF2L protein network | https://string-db.org/network/9606.ENSP00000359600 | Outer dense fiber of sperm tails 2 like |
| COL24A1 protein network | https://string-db.org/network/9606.ENSP00000359603 | Collagen alpha-1(XXIV) chain; May participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development; Belongs to the fibrillar collagen family |
| ZNHIT6 protein network | https://string-db.org/network/9606.ENSP00000359606 | Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis; Belongs to the BCD1 family |
| PYROXD2 protein network | https://string-db.org/network/9606.ENSP00000359607 | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase |
| LMBRD1 protein network | https://string-db.org/network/9606.ENSP00000359609 | Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. Isoform 3 may play a role in [...] |
| BCL10 protein network | https://string-db.org/network/9606.ENSP00000359612 | B-cell lymphoma/leukemia 10; Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF- kappa-B via NIK and IKK. May be an adapter protein between up [...] |
| MCOLN3 protein network | https://string-db.org/network/9606.ENSP00000359621 | Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying ac [...] |
| CRTAC1 protein network | https://string-db.org/network/9606.ENSP00000359629 | Cartilage acidic protein 1 |
| BAI3 protein network | https://string-db.org/network/9606.ENSP00000359630 | Adhesion G protein-coupled receptor B3; Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity ( [...] |
| GOLGA7B protein network | https://string-db.org/network/9606.ENSP00000359634 | Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family |
| MCOLN2 protein network | https://string-db.org/network/9606.ENSP00000359640 | Mucolipin-2; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity. May [...] |
| RBMX protein network | https://string-db.org/network/9606.ENSP00000359645 | RNA-binding motif protein, X chromosome; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene [...] |
| AVPI1 protein network | https://string-db.org/network/9606.ENSP00000359660 | Arginine vasopressin-induced protein 1; May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling |
| CD40LG protein network | https://string-db.org/network/9606.ENSP00000359663 | CD40 ligand; Cytokine that binds to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the produ [...] |
| CTBS protein network | https://string-db.org/network/9606.ENSP00000359664 | Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of [...] |
| PI4K2A protein network | https://string-db.org/network/9606.ENSP00000359665 | Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4- kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-ph [...] |
| VGLL1 protein network | https://string-db.org/network/9606.ENSP00000359668 | Transcription cofactor vestigial-like protein 1; May act as a specific coactivator for the mammalian TEFs; Belongs to the vestigial family |
| C10orf62 protein network | https://string-db.org/network/9606.ENSP00000359674 | Uncharacterized protein C10orf62; Chromosome 10 open reading frame 62 |
| GNG5 protein network | https://string-db.org/network/9606.ENSP00000359675 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| HOGA1 protein network | https://string-db.org/network/9606.ENSP00000359680 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline |
| BRS3 protein network | https://string-db.org/network/9606.ENSP00000359682 | Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium se [...] |
| ENSG00000249967 protein network | https://string-db.org/network/9606.ENSP00000359683 | Uncharacterized protein; Phosphatidylinositol 4-kinase type 2-alpha; Uncharacterized protein |
| PTP4A1 protein network | https://string-db.org/network/9606.ENSP00000359685 | Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of diffe [...] |
| RPF1 protein network | https://string-db.org/network/9606.ENSP00000359688 | Ribosome production factor 1; May be required for ribosome biogenesis |
| LGSN protein network | https://string-db.org/network/9606.ENSP00000359691 | Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have e [...] |
| FKBP1C protein network | https://string-db.org/network/9606.ENSP00000359693 | Peptidylprolyl isomerase; FK506 binding protein 1C; FKBP prolyl isomerases |
| UBTD1 protein network | https://string-db.org/network/9606.ENSP00000359698 | Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the sta [...] |
| DNASE2B protein network | https://string-db.org/network/9606.ENSP00000359699 | Deoxyribonuclease-2-beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation |
| SAMD13 protein network | https://string-db.org/network/9606.ENSP00000359707 | Sterile alpha motif domain containing 13 |
| PRKACB protein network | https://string-db.org/network/9606.ENSP00000359719 | cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell pr [...] |
| BAG2 protein network | https://string-db.org/network/9606.ENSP00000359727 | BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...] |
| SLC9A6 protein network | https://string-db.org/network/9606.ENSP00000359729 | Sodium/hydrogen exchanger 6; Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis; Solute carriers |
| ZNF451 protein network | https://string-db.org/network/9606.ENSP00000359740 | E3 SUMO-protein ligase ZNF451; E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modif [...] |
| KIAA1586 protein network | https://string-db.org/network/9606.ENSP00000359768 | E3 SUMO-protein ligase KIAA1586; E3 SUMO-protein ligase; facilitates UBE2I/UBC9-mediated SUMO2 modification of target proteins |
| ELTD1 protein network | https://string-db.org/network/9606.ENSP00000359778 | Adhesion G protein-coupled receptor L4; Endothelial orphan receptor that acts as a key regulator of angiogenesis |
| BEND6 protein network | https://string-db.org/network/9606.ENSP00000359782 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-ren [...] |
| IFI44 protein network | https://string-db.org/network/9606.ENSP00000359783 | Interferon-induced protein 44; This protein aggregates to form microtubular structures; Belongs to the IFI44 family |
| IFI44L protein network | https://string-db.org/network/9606.ENSP00000359787 | Interferon-induced protein 44-like; Exhibits a low antiviral activity against hepatitis C virus; Belongs to the IFI44 family |
| DDX26B protein network | https://string-db.org/network/9606.ENSP00000359788 | Integrator complex subunit 6-like; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B |
| PTGFR protein network | https://string-db.org/network/9606.ENSP00000359793 | Prostaglandin F2-alpha receptor; Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second mes [...] |
| GIPC2 protein network | https://string-db.org/network/9606.ENSP00000359795 | PDZ domain-containing protein GIPC2; GIPC PDZ domain containing family member 2; Belongs to the GIPC family |
| DNAJB4 protein network | https://string-db.org/network/9606.ENSP00000359799 | DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro); DNAJ heat shock proteins |
| ZNF75D protein network | https://string-db.org/network/9606.ENSP00000359802 | Zinc finger protein 75D; May be involved in transcriptional regulation; SCAN domain containing |
| FUBP1 protein network | https://string-db.org/network/9606.ENSP00000359804 | Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor [...] |
| MOSPD1 protein network | https://string-db.org/network/9606.ENSP00000359819 | Motile sperm domain-containing protein 1; Plays a role in differentiation and/or proliferation of mesenchymal stem cells. Proposed to be involved in epithelial-to- mesenchymal transition (EMT). H [...] |
| FAM122C protein network | https://string-db.org/network/9606.ENSP00000359820 | Protein FAM122C; Family with sequence similarity 122C |
| USP33 protein network | https://string-db.org/network/9606.ENSP00000359829 | Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. [...] |
| ZZZ3 protein network | https://string-db.org/network/9606.ENSP00000359837 | ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 |
| PIGK protein network | https://string-db.org/network/9606.ENSP00000359848 | GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidatio [...] |
| MTG2 protein network | https://string-db.org/network/9606.ENSP00000359859 | Mitochondrial ribosome-associated GTPase 2; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays GTPase activity. Involved in the ribosome [...] |
| GPC4 protein network | https://string-db.org/network/9606.ENSP00000359864 | Glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity); Belongs to the glypican f [...] |
| BMP5 protein network | https://string-db.org/network/9606.ENSP00000359866 | Bone morphogenetic protein 5; Induces cartilage and bone formation; Bone morphogenetic proteins |
| ACADM protein network | https://string-db.org/network/9606.ENSP00000359871 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta- oxidation. Utili [...] |
| MBNL3 protein network | https://string-db.org/network/9606.ENSP00000359890 | Muscleblind-like protein 3; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) [...] |
| SLC44A5 protein network | https://string-db.org/network/9606.ENSP00000359892 | Choline transporter-like protein 5; Solute carrier family 44 member 5; Belongs to the CTL (choline transporter-like) family |
| TYW3 protein network | https://string-db.org/network/9606.ENSP00000359904 | tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper [...] |
| PSMA7 protein network | https://string-db.org/network/9606.ENSP00000359910 | Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| LRRC1 protein network | https://string-db.org/network/9606.ENSP00000359925 | Leucine-rich repeat-containing protein 1; Leucine rich repeat containing 1 |
| FPGT protein network | https://string-db.org/network/9606.ENSP00000359935 | Fucose-1-phosphate guanylyltransferase; Catalyzes the formation of GDP-L-fucose from GTP and L- fucose-1-phosphate. Functions as a salvage pathway to reutilize L- fucose arising from the turnover [...] |
| EXOSC1 protein network | https://string-db.org/network/9606.ENSP00000359939 | Exosome complex component CSL4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...] |
| IGSF1 protein network | https://string-db.org/network/9606.ENSP00000359940 | Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absenc [...] |
| KLHL31 protein network | https://string-db.org/network/9606.ENSP00000359942 | Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response elem [...] |
| ELOVL5 protein network | https://string-db.org/network/9606.ENSP00000359956 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| ZRANB2 protein network | https://string-db.org/network/9606.ENSP00000359958 | Zinc finger Ran-binding domain-containing protein 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'- splice site selection; Zinc f [...] |
| CTH protein network | https://string-db.org/network/9606.ENSP00000359976 | Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2 [...] |
| HHLA3 protein network | https://string-db.org/network/9606.ENSP00000359978 | HERV-H LTR-associating 3 |
| ANKRD13C protein network | https://string-db.org/network/9606.ENSP00000359982 | Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER; Ankyrin repeat domain containing |
| SRSF11 protein network | https://string-db.org/network/9606.ENSP00000359988 | Serine/arginine-rich splicing factor 11; May function in pre-mRNA splicing; RNA binding motif containing |
| LRRC40 protein network | https://string-db.org/network/9606.ENSP00000359990 | Leucine-rich repeat-containing protein 40; Leucine rich repeat containing 40 |
| PGAM1 protein network | https://string-db.org/network/9606.ENSP00000359991 | Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but w [...] |
| GSTA4 protein network | https://string-db.org/network/9606.ENSP00000360002 | Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydrox [...] |
| ZNF280C protein network | https://string-db.org/network/9606.ENSP00000360017 | Zinc finger protein 280C; May function as a transcription factor |
| DIRAS3 protein network | https://string-db.org/network/9606.ENSP00000360020 | GTP-binding protein Di-Ras3; RAS type GTPase family |
| GNG12 protein network | https://string-db.org/network/9606.ENSP00000360021 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...] |
| GADD45A protein network | https://string-db.org/network/9606.ENSP00000360025 | Growth arrest and DNA damage-inducible protein GADD45 alpha; In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA in [...] |
| GSTA5 protein network | https://string-db.org/network/9606.ENSP00000360028 | Soluble glutathione S-transferases; Belongs to the GST superfamily. Alpha family |
| SERBP1 protein network | https://string-db.org/network/9606.ENSP00000360034 | Plasminogen activator inhibitor 1 RNA-binding protein; May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nu [...] |
| PPP1R3D protein network | https://string-db.org/network/9606.ENSP00000360035 | Protein phosphatase 1 regulatory subunit 3D; Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, m [...] |
| C1orf141 protein network | https://string-db.org/network/9606.ENSP00000360046 | Uncharacterized protein C1orf141; Chromosome 1 open reading frame 141 |
| PHACTR3 protein network | https://string-db.org/network/9606.ENSP00000360054 | Phosphatase and actin regulator 3; Protein phosphatase 1 regulatory subunits; Phosphatase and actin regulators |
| FRAT2 protein network | https://string-db.org/network/9606.ENSP00000360058 | GSK-3-binding protein FRAT2; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3 |
| FRAT1 protein network | https://string-db.org/network/9606.ENSP00000360060 | Proto-oncogene FRAT1; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 [...] |
| WDR78 protein network | https://string-db.org/network/9606.ENSP00000360065 | WD repeat-containing protein 78; WD repeat domain containing |
| ZNF831 protein network | https://string-db.org/network/9606.ENSP00000360069 | Zinc finger protein 831 |
| SGIP1 protein network | https://string-db.org/network/9606.ENSP00000360076 | SH3-containing GRB2-like protein 3-interacting protein 1; May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essent [...] |
| EFHC1 protein network | https://string-db.org/network/9606.ENSP00000360107 | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. N [...] |
| DNAJC6 protein network | https://string-db.org/network/9606.ENSP00000360108 | Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis i [...] |
| RAVER2 protein network | https://string-db.org/network/9606.ENSP00000360112 | Ribonucleoprotein PTB-binding 2; May bind single-stranded nucleic acids; RNA binding motif containing |
| UBE2U protein network | https://string-db.org/network/9606.ENSP00000360116 | Ubiquitin-conjugating enzyme E2 U; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family |
| ROR1 protein network | https://string-db.org/network/9606.ENSP00000360120 | Inactive tyrosine-protein kinase transmembrane receptor ROR1; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activ [...] |
| PGM1 protein network | https://string-db.org/network/9606.ENSP00000360124 | Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family |
| EFCAB7 protein network | https://string-db.org/network/9606.ENSP00000360129 | EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcompl [...] |
| ITGB3BP protein network | https://string-db.org/network/9606.ENSP00000360133 | Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors f [...] |
| LCOR protein network | https://string-db.org/network/9606.ENSP00000360138 | Ligand-dependent corepressor; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcriptio [...] |
| GNAS protein network | https://string-db.org/network/9606.ENSP00000360141 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protei [...] |
| XPNPEP2 protein network | https://string-db.org/network/9606.ENSP00000360147 | Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the me [...] |
| ALG6 protein network | https://string-db.org/network/9606.ENSP00000360149 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from d [...] |
| OCRL protein network | https://string-db.org/network/9606.ENSP00000360154 | Inositol polyphosphate 5-phosphatase OCRL-1; Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bispho [...] |
| FOXD3 protein network | https://string-db.org/network/9606.ENSP00000360157 | Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural [...] |
| PKHD1 protein network | https://string-db.org/network/9606.ENSP00000360158 | Fibrocystin; May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly. May be a receptor protein that acts in collecting-duc [...] |
| SMARCA1 protein network | https://string-db.org/network/9606.ENSP00000360162 | Probable global transcription activator SNF2L1; Energy-transducing component of NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes. Both complexes facili [...] |
| ACTRT1 protein network | https://string-db.org/network/9606.ENSP00000360165 | Negatively regulates the Hedgehog (SHH) signaling. Binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression |
| PRR32 protein network | https://string-db.org/network/9606.ENSP00000360166 | Proline-rich protein 32; Proline rich 32 |
| DCAF12L1 protein network | https://string-db.org/network/9606.ENSP00000360167 | DDB1- and CUL4-associated factor 12-like protein 1; DDB1 and CUL4 associated factor 12 like 1; WD repeat domain containing |
| ANGPTL3 protein network | https://string-db.org/network/9606.ENSP00000360170 | Angiopoietin-related protein 3; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to eit [...] |
| SH2D1A protein network | https://string-db.org/network/9606.ENSP00000360181 | SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In S [...] |
| STX16 protein network | https://string-db.org/network/9606.ENSP00000360183 | Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family |
| TM9SF3 protein network | https://string-db.org/network/9606.ENSP00000360184 | Transmembrane 9 superfamily member 3 |
| DEFB110 protein network | https://string-db.org/network/9606.ENSP00000360190 | Beta-defensin 110; Has antibacterial activity; Defensins, beta |
| APCDD1L protein network | https://string-db.org/network/9606.ENSP00000360191 | Protein APCDD1-like; APC down-regulated 1 like |
| KANK4 protein network | https://string-db.org/network/9606.ENSP00000360195 | KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization; Ankyrin repeat domain containing |
| INADL protein network | https://string-db.org/network/9606.ENSP00000360200 | InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctio [...] |
| C20orf85 protein network | https://string-db.org/network/9606.ENSP00000360210 | Uncharacterized protein C20orf85; Chromosome 20 open reading frame 85 |
| OPALIN protein network | https://string-db.org/network/9606.ENSP00000360214 | Opalin; Oligodendrocytic myelin paranodal and inner loop protein |
| ZBP1 protein network | https://string-db.org/network/9606.ENSP00000360215 | Z-DNA-binding protein 1; Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathoge [...] |
| DNTT protein network | https://string-db.org/network/9606.ENSP00000360216 | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo func [...] |
| RHAG protein network | https://string-db.org/network/9606.ENSP00000360217 | Ammonium transporter Rh type A; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythroc [...] |
| NFIA protein network | https://string-db.org/network/9606.ENSP00000360231 | Nuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...] |
| GLYATL3 protein network | https://string-db.org/network/9606.ENSP00000360240 | Glycine N-acyltransferase-like protein 3; Acyltransferase which transfers the acyl group to the N- terminus of glycine |
| XIAP protein network | https://string-db.org/network/9606.ENSP00000360242 | E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic k [...] |
| C1orf87 protein network | https://string-db.org/network/9606.ENSP00000360244 | Uncharacterized protein C1orf87; Chromosome 1 open reading frame 87 |
| CYP2J2 protein network | https://string-db.org/network/9606.ENSP00000360247 | Cytochrome P450 2J2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominan [...] |
| ENTPD1 protein network | https://string-db.org/network/9606.ENSP00000360250 | Ectonucleoside triphosphate diphosphohydrolase 1; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the preven [...] |
| HOOK1 protein network | https://string-db.org/network/9606.ENSP00000360252 | Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (B [...] |
| OPN5 protein network | https://string-db.org/network/9606.ENSP00000360255 | Opsin-5; Opsin receptors |
| FGGY protein network | https://string-db.org/network/9606.ENSP00000360262 | FGGY carbohydrate kinase domain containing; Belongs to the FGGY kinase family |
| JUN protein network | https://string-db.org/network/9606.ENSP00000360266 | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to incre [...] |
| ALDH18A1 protein network | https://string-db.org/network/9606.ENSP00000360268 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine |
| TACSTD2 protein network | https://string-db.org/network/9606.ENSP00000360269 | Tumor-associated calcium signal transducer 2; May function as a growth factor receptor; Belongs to the EPCAM family |
| OMA1 protein network | https://string-db.org/network/9606.ENSP00000360270 | Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitocho [...] |
| DAB1 protein network | https://string-db.org/network/9606.ENSP00000360280 | Disabled homolog 1; Adapter molecule functioning in neural development. May regulate SIAH1 activity |
| C8B protein network | https://string-db.org/network/9606.ENSP00000360281 | Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of ta [...] |
| PRKAA2 protein network | https://string-db.org/network/9606.ENSP00000360290 | 5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular e [...] |
| SORBS1 protein network | https://string-db.org/network/9606.ENSP00000360293 | Sorbin and SH3 domain-containing protein 1; Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in [...] |
| PPAP2B protein network | https://string-db.org/network/9606.ENSP00000360296 | Phospholipid phosphatase 3; Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphi [...] |
| GPR110 protein network | https://string-db.org/network/9606.ENSP00000360299 | Adhesion G-protein coupled receptor F1; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily |
| PDLIM1 protein network | https://string-db.org/network/9606.ENSP00000360305 | PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of [...] |
| SPO11 protein network | https://string-db.org/network/9606.ENSP00000360310 | Meiotic recombination protein SPO11; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-stra [...] |
| BSND protein network | https://string-db.org/network/9606.ENSP00000360312 | Barttin; Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stri [...] |
| TMEM61 protein network | https://string-db.org/network/9606.ENSP00000360315 | Transmembrane protein 61 |
| DHCR24 protein network | https://string-db.org/network/9606.ENSP00000360316 | Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induc [...] |
| CYP2C8 protein network | https://string-db.org/network/9606.ENSP00000360317 | Cytochrome P450 2C8; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| C1orf177 protein network | https://string-db.org/network/9606.ENSP00000360320 | Lymphocyte expansion molecule; Chromosome 1 open reading frame 177 |
| TTC22 protein network | https://string-db.org/network/9606.ENSP00000360323 | Tetratricopeptide repeat domain containing |
| PARS2 protein network | https://string-db.org/network/9606.ENSP00000360327 | Probable proline--tRNA ligase, mitochondrial; prolyl-tRNA synthetase 2, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family |
| TTC4 protein network | https://string-db.org/network/9606.ENSP00000360329 | Tetratricopeptide repeat domain containing; Belongs to the TTC4 family |
| CT47B1 protein network | https://string-db.org/network/9606.ENSP00000360360 | Cancer/testis antigen family 47, member B1 |
| MCTS1 protein network | https://string-db.org/network/9606.ENSP00000360365 | Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit t [...] |
| ACOT11 protein network | https://string-db.org/network/9606.ENSP00000360366 | Acyl-coenzyme A thioesterase 11; Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates |
| SSBP3 protein network | https://string-db.org/network/9606.ENSP00000360371 | Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter r [...] |
| CYP2C19 protein network | https://string-db.org/network/9606.ENSP00000360372 | Cytochrome P450 2C19; Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propra [...] |
| FAM209B protein network | https://string-db.org/network/9606.ENSP00000360376 | Protein FAM209B; Family with sequence similarity 209 member B |
| FAM209A protein network | https://string-db.org/network/9606.ENSP00000360379 | Protein FAM209A; Family with sequence similarity 209 member A |
| CDCP2 protein network | https://string-db.org/network/9606.ENSP00000360381 | CUB domain containing protein 2 |
| SLC25A27 protein network | https://string-db.org/network/9606.ENSP00000360398 | Mitochondrial uncoupling protein 4; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP [...] |
| LDLRAD1 protein network | https://string-db.org/network/9606.ENSP00000360411 | Low density lipoprotein receptor class A domain containing 1 |
| NOC3L protein network | https://string-db.org/network/9606.ENSP00000360412 | Nucleolar complex protein 3 homolog; May be required for adipogenesis; Armadillo-like helical domain containing |
| LRRC42 protein network | https://string-db.org/network/9606.ENSP00000360421 | Leucine-rich repeat-containing protein 42; Leucine rich repeat containing 42; Belongs to the LRRC42 family |
| CACNA1B protein network | https://string-db.org/network/9606.ENSP00000360423 | Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| RCAN2 protein network | https://string-db.org/network/9606.ENSP00000360425 | Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs [...] |
| PLCE1 protein network | https://string-db.org/network/9606.ENSP00000360431 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by ac [...] |
| ENPP5 protein network | https://string-db.org/network/9606.ENSP00000360436 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity); Be [...] |
| FAM210B protein network | https://string-db.org/network/9606.ENSP00000360437 | Protein FAM210B, mitochondrial; Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cell [...] |
| RHOXF2 protein network | https://string-db.org/network/9606.ENSP00000360441 | Rhox homeobox family member 2; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogene [...] |
| RHOXF2B protein network | https://string-db.org/network/9606.ENSP00000360455 | Rhox homeobox family member 2B; Transcription factor maybe involved in reproductive processes. Modulates expression of target genes encoding proteins involved in processes relevant to spermatogen [...] |
| NKAP protein network | https://string-db.org/network/9606.ENSP00000360464 | NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in [...] |
| LGI1 protein network | https://string-db.org/network/9606.ENSP00000360472 | Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure medi [...] |
| PFDN4 protein network | https://string-db.org/network/9606.ENSP00000360473 | Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| ARRDC1 protein network | https://string-db.org/network/9606.ENSP00000360475 | Arrestin domain-containing protein 1; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a [...] |
| NDC1 protein network | https://string-db.org/network/9606.ENSP00000360483 | Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assem [...] |
| AKAP14 protein network | https://string-db.org/network/9606.ENSP00000360485 | A-kinase anchor protein 14; Binds to type II regulatory subunits of protein kinase A and anchors/targets them; A-kinase anchoring proteins |
| FRA10AC1 protein network | https://string-db.org/network/9606.ENSP00000360488 | Protein FRA10AC1; FRA10A associated CGG repeat 1; Spliceosomal C complex |
| NDUFA1 protein network | https://string-db.org/network/9606.ENSP00000360492 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| RUNX2 protein network | https://string-db.org/network/9606.ENSP00000360493 | Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous [...] |
| RNF113A protein network | https://string-db.org/network/9606.ENSP00000360497 | RING finger protein 113A; Spliceosomal Bact complex; Ring finger proteins |
| MRPL41 protein network | https://string-db.org/network/9606.ENSP00000360498 | 39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p5 [...] |
| DMRTB1 protein network | https://string-db.org/network/9606.ENSP00000360500 | Doublesex- and mab-3-related transcription factor B1; DMRT like family B with proline rich C-terminal 1; Belongs to the DMRT family |
| PDE6C protein network | https://string-db.org/network/9606.ENSP00000360502 | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decre [...] |
| SUPT3H protein network | https://string-db.org/network/9606.ENSP00000360515 | Transcription initiation protein SPT3 homolog; Probable transcriptional activator; SAGA complex |
| RBP4 protein network | https://string-db.org/network/9606.ENSP00000360522 | Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the boun [...] |
| MAGOH protein network | https://string-db.org/network/9606.ENSP00000360525 | Protein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of [...] |
| ZNF217 protein network | https://string-db.org/network/9606.ENSP00000360526 | Zinc finger protein 217; Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'; [...] |
| NSMF protein network | https://string-db.org/network/9606.ENSP00000360530 | NMDA receptor synaptonuclear signaling and neuronal migration factor; Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture [...] |
| CDC5L protein network | https://string-db.org/network/9606.ENSP00000360532 | Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of t [...] |
| FFAR4 protein network | https://string-db.org/network/9606.ENSP00000360538 | Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust an [...] |
| CEP55 protein network | https://string-db.org/network/9606.ENSP00000360540 | Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not requ [...] |
| CPT2 protein network | https://string-db.org/network/9606.ENSP00000360541 | Carnitine O-palmitoyltransferase 2, mitochondrial; Carnitine palmitoyltransferase 2 |
| TSHZ2 protein network | https://string-db.org/network/9606.ENSP00000360552 | Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential); ZF class homeoboxes and pseudogenes |
| TCTE1 protein network | https://string-db.org/network/9606.ENSP00000360560 | T-complex-associated-testis-expressed 1; Dynein regulatory complex |
| ENTPD8 protein network | https://string-db.org/network/9606.ENSP00000360561 | Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- a [...] |
| SCP2 protein network | https://string-db.org/network/9606.ENSP00000360569 | Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis |
| NDOR1 protein network | https://string-db.org/network/9606.ENSP00000360576 | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By simi [...] |
| ECHDC2 protein network | https://string-db.org/network/9606.ENSP00000360577 | Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; enoyl-CoA hydratase domain containing 2; Belongs to the enoyl-CoA hydratase/isomerase family |
| ZYG11A protein network | https://string-db.org/network/9606.ENSP00000360583 | Protein zyg-11 homolog A; Probably acts as target recruitment subunit in an E3 ubiquitin ligase complex ZYGA-CUL2-elongin BC; Armadillo-like helical domain containing |
| COA7 protein network | https://string-db.org/network/9606.ENSP00000360593 | Cytochrome c oxidase assembly factor 7; Required for assembly of mitochondrial respiratory chain complex I and complex IV |
| LRRC26 protein network | https://string-db.org/network/9606.ENSP00000360597 | Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels [...] |
| GRIN1 protein network | https://string-db.org/network/9606.ENSP00000360608 | Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensi [...] |
| HSP90AB1 protein network | https://string-db.org/network/9606.ENSP00000360609 | Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle cont [...] |
| UBE2A protein network | https://string-db.org/network/9606.ENSP00000360613 | Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it p [...] |
| ORC1 protein network | https://string-db.org/network/9606.ENSP00000360623 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of r [...] |
| KCNG1 protein network | https://string-db.org/network/9606.ENSP00000360626 | Potassium voltage-gated channel subfamily G member 1; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...] |
| DPP7 protein network | https://string-db.org/network/9606.ENSP00000360635 | Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; DASH family |
| CC2D1B protein network | https://string-db.org/network/9606.ENSP00000360642 | Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; C2 doma [...] |
| DPM1 protein network | https://string-db.org/network/9606.ENSP00000360644 | Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathwa [...] |
| MAN1B1 protein network | https://string-db.org/network/9606.ENSP00000360645 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single al [...] |
| NPDC1 protein network | https://string-db.org/network/9606.ENSP00000360660 | Neural proliferation differentiation and control protein 1; Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in [...] |
| BTF3L4 protein network | https://string-db.org/network/9606.ENSP00000360664 | Basic transcription factor 3 like 4; Belongs to the NAC-beta family |
| SLC25A5 protein network | https://string-db.org/network/9606.ENSP00000360671 | ADP/ATP translocase 2; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play [...] |
| PARD6B protein network | https://string-db.org/network/9606.ENSP00000360672 | Partitioning defective 6 homolog beta; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Associ [...] |
| KTI12 protein network | https://string-db.org/network/9606.ENSP00000360676 | KTI12 chromatin associated homolog |
| C9orf142 protein network | https://string-db.org/network/9606.ENSP00000360682 | Protein PAXX; Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRC [...] |
| PTPN1 protein network | https://string-db.org/network/9606.ENSP00000360683 | Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/ [...] |
| PTGDS protein network | https://string-db.org/network/9606.ENSP00000360687 | Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved i [...] |
| TXNDC12 protein network | https://string-db.org/network/9606.ENSP00000360688 | Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity |
| TNKS2 protein network | https://string-db.org/network/9606.ENSP00000360689 | Tankyrase-2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by [...] |
| LONRF3 protein network | https://string-db.org/network/9606.ENSP00000360690 | LON peptidase N-terminal domain and ring finger 3 |
| LCN12 protein network | https://string-db.org/network/9606.ENSP00000360696 | Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Lipocalins |
| TMEM189 protein network | https://string-db.org/network/9606.ENSP00000360715 | Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane . Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether [...] |
| RAB3B protein network | https://string-db.org/network/9606.ENSP00000360718 | Ras-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases |
| RABL6 protein network | https://string-db.org/network/9606.ENSP00000360727 | Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A; Belongs to the small GTPase superfamily. Rab family |
| IL13RA1 protein network | https://string-db.org/network/9606.ENSP00000360730 | Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory prote [...] |
| LCN8 protein network | https://string-db.org/network/9606.ENSP00000360753 | Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis; Lipocalins |
| FAM69B protein network | https://string-db.org/network/9606.ENSP00000360757 | Protein FAM69B; Family with sequence similarity 69 member B; Belongs to the FAM69 family |
| AGPAT2 protein network | https://string-db.org/network/9606.ENSP00000360761 | 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone; Bel [...] |
| ANKRD1 protein network | https://string-db.org/network/9606.ENSP00000360762 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardia [...] |
| EGFL7 protein network | https://string-db.org/network/9606.ENSP00000360764 | Epidermal growth factor-like protein 7; Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial c [...] |
| B4GALT5 protein network | https://string-db.org/network/9606.ENSP00000360776 | Beta-1,4-galactosyltransferase 5; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Beta 4-glycosy [...] |
| INPP5E protein network | https://string-db.org/network/9606.ENSP00000360777 | 72 kDa inositol polyphosphate 5-phosphatase; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4 [...] |
| PMPCA protein network | https://string-db.org/network/9606.ENSP00000360782 | Mitochondrial-processing peptidase subunit alpha; Cleaves presequences (transit peptides) from mitochondrial protein precursors; Belongs to the peptidase M16 family |
| KIF20B protein network | https://string-db.org/network/9606.ENSP00000360793 | Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis. Required for proper midbody organization and abscission in polarized cortical stem cell [...] |
| CARD9 protein network | https://string-db.org/network/9606.ENSP00000360797 | Caspase recruitment domain-containing protein 9; Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is [...] |
| EPS15 protein network | https://string-db.org/network/9606.ENSP00000360798 | Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the intern [...] |
| DNLZ protein network | https://string-db.org/network/9606.ENSP00000360803 | DNL-type zinc finger protein; May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation; Zinc fingers |
| KCNB1 protein network | https://string-db.org/network/9606.ENSP00000360806 | Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in t [...] |
| LHX3 protein network | https://string-db.org/network/9606.ENSP00000360811 | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin p [...] |
| UBAC1 protein network | https://string-db.org/network/9606.ENSP00000360821 | Ubiquitin-associated domain-containing protein 1; Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degra [...] |
| KCNT1 protein network | https://string-db.org/network/9606.ENSP00000360822 | Potassium channel subfamily T member 1; Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride [...] |
| C1orf185 protein network | https://string-db.org/network/9606.ENSP00000360824 | Uncharacterized protein C1orf185; Chromosome 1 open reading frame 185 |
| GLT6D1 protein network | https://string-db.org/network/9606.ENSP00000360829 | Belongs to the glycosyltransferase 6 family |
| MRPS2 protein network | https://string-db.org/network/9606.ENSP00000360850 | Mitochondrial ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family |
| SLC16A12 protein network | https://string-db.org/network/9606.ENSP00000360855 | Monocarboxylate transporter 12; Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane; Belongs to the major facilitator superfamily. Monocarboxylat [...] |
| OLFM1 protein network | https://string-db.org/network/9606.ENSP00000360858 | Noelin; Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth c [...] |
| IFIT5 protein network | https://string-db.org/network/9606.ENSP00000360860 | Interferon-induced protein with tetratricopeptide repeats 5; Interferon-induced RNA-binding protein involved in the human innate immune response. Has a broad and adaptable RNA structure recogniti [...] |
| IFIT1 protein network | https://string-db.org/network/9606.ENSP00000360869 | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA) [...] |
| FCN1 protein network | https://string-db.org/network/9606.ENSP00000360871 | Ficolin-1; Extracellular lectin functioning as a pattern- recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes [...] |
| IFIT1B protein network | https://string-db.org/network/9606.ENSP00000360874 | Interferon induced protein with tetratricopeptide repeats 1B |
| COL5A1 protein network | https://string-db.org/network/9606.ENSP00000360882 | Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...] |
| IFIT3 protein network | https://string-db.org/network/9606.ENSP00000360883 | Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signal [...] |
| IFIT2 protein network | https://string-db.org/network/9606.ENSP00000360891 | Interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'- [...] |
| BEND5 protein network | https://string-db.org/network/9606.ENSP00000360899 | BEN domain-containing protein 5; Acts as a transcriptional repressor; BEN domain containing |
| AGBL4 protein network | https://string-db.org/network/9606.ENSP00000360905 | Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...] |
| SPATA6 protein network | https://string-db.org/network/9606.ENSP00000360913 | Spermatogenesis-associated protein 6; Required for formation of the sperm connecting piece during spermiogenesis. Sperm connecting piece is essential for linking the developing flagellum to the h [...] |
| VAV2 protein network | https://string-db.org/network/9606.ENSP00000360916 | Guanine nucleotide exchange factor VAV2; Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated E [...] |
| CH25H protein network | https://string-db.org/network/9606.ENSP00000360918 | Cholesterol 25-hydroxylase; Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and moveme [...] |
| STAU1 protein network | https://string-db.org/network/9606.ENSP00000360922 | Double-stranded RNA-binding protein Staufen homolog 1; Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the c [...] |
| SARDH protein network | https://string-db.org/network/9606.ENSP00000360938 | Sarcosine dehydrogenase, mitochondrial; Sarcosine dehydrogenase; Belongs to the GcvT family |
| CMPK1 protein network | https://string-db.org/network/9606.ENSP00000360939 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference [...] |
| STIL protein network | https://string-db.org/network/9606.ENSP00000360944 | SCL-interrupting locus protein; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell surviv [...] |
| CYP4A22 protein network | https://string-db.org/network/9606.ENSP00000360958 | Cytochrome P450 4A22; Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks [...] |
| CT83 protein network | https://string-db.org/network/9606.ENSP00000360961 | Kita-kyushu lung cancer antigen 1; Cancer/testis antigen 83 |
| SLC2A6 protein network | https://string-db.org/network/9606.ENSP00000360966 | Solute carrier family 2, facilitated glucose transporter member 6; Facilitative glucose transporter; binds cytochalasin B with low affinity; Belongs to the major facilitator superfamily. Sugar tr [...] |
| CYP4X1 protein network | https://string-db.org/network/9606.ENSP00000360968 | Cytochrome P450 family 4 subfamily X member 1 |
| AGTR2 protein network | https://string-db.org/network/9606.ENSP00000360973 | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation |
| ARFGEF2 protein network | https://string-db.org/network/9606.ENSP00000360985 | Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF [...] |
| LUZP4 protein network | https://string-db.org/network/9606.ENSP00000360988 | Leucine zipper protein 4; Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA expor [...] |
| CYP4B1 protein network | https://string-db.org/network/9606.ENSP00000360991 | Cytochrome P450 4B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| STAMBPL1 protein network | https://string-db.org/network/9606.ENSP00000360994 | AMSH-like protease; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains; Belongs to the peptidase M67C famil [...] |
| ADAMTS13 protein network | https://string-db.org/network/9606.ENSP00000360997 | A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation; ADAM metall [...] |
| ANKRD22 protein network | https://string-db.org/network/9606.ENSP00000360998 | Ankyrin repeat domain-containing protein 22; Ankyrin repeat domain containing |
| EFCAB14 protein network | https://string-db.org/network/9606.ENSP00000361001 | EF-hand calcium-binding domain-containing protein 14; EF-hand calcium binding domain 14 |
| IL13RA2 protein network | https://string-db.org/network/9606.ENSP00000361004 | Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4); CD molecules |
| LIPJ protein network | https://string-db.org/network/9606.ENSP00000361007 | Lipase family member J; Belongs to the AB hydrolase superfamily. Lipase family |
| PREX1 protein network | https://string-db.org/network/9606.ENSP00000361009 | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP f [...] |
| REXO4 protein network | https://string-db.org/network/9606.ENSP00000361010 | REX4 homolog, 3'-5' exonuclease; Exonucleases |
| MKNK1 protein network | https://string-db.org/network/9606.ENSP00000361014 | MAP kinase-interacting serine/threonine-protein kinase 1; May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus inc [...] |
| PTEN protein network | https://string-db.org/network/9606.ENSP00000361021 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid [...] |
| STKLD1 protein network | https://string-db.org/network/9606.ENSP00000361025 | Serine/threonine kinase-like domain-containing protein STKLD1; Serine/threonine kinase like domain containing 1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL sub [...] |
| AMOT protein network | https://string-db.org/network/9606.ENSP00000361027 | Angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regula [...] |
| SURF2 protein network | https://string-db.org/network/9606.ENSP00000361032 | Surfeit 2; Belongs to the SURF2 family |
| LHFPL1 protein network | https://string-db.org/network/9606.ENSP00000361036 | LHFPL tetraspan subfamily member 1 |
| SURF1 protein network | https://string-db.org/network/9606.ENSP00000361042 | Surfeit locus protein 1; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly |
| RAD54L protein network | https://string-db.org/network/9606.ENSP00000361043 | DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotei [...] |
| LURAP1 protein network | https://string-db.org/network/9606.ENSP00000361048 | Leucine rich adaptor protein 1; Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming fu [...] |
| SURF4 protein network | https://string-db.org/network/9606.ENSP00000361057 | Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi; Belongs to the SURF4 family |
| POMGNT1 protein network | https://string-db.org/network/9606.ENSP00000361060 | Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; Participates in O-mannosyl glycosylation. May be responsible for the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O- Ser/Thr mo [...] |
| MINPP1 protein network | https://string-db.org/network/9606.ENSP00000361064 | Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol h [...] |
| NCOA3 protein network | https://string-db.org/network/9606.ENSP00000361066 | Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central ro [...] |
| TSPAN1 protein network | https://string-db.org/network/9606.ENSP00000361072 | Tetraspanin-1; Tetraspanin 1; Tetraspanins |
| RPL7A protein network | https://string-db.org/network/9606.ENSP00000361076 | Ribosomal protein L7a |
| ADIRF protein network | https://string-db.org/network/9606.ENSP00000361083 | Adipogenesis regulatory factor; Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEB [...] |
| MRPL14 protein network | https://string-db.org/network/9606.ENSP00000361084 | 39S ribosomal protein L14, mitochondrial; Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome form [...] |
| SNCG protein network | https://string-db.org/network/9606.ENSP00000361087 | Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of [...] |
| SURF6 protein network | https://string-db.org/network/9606.ENSP00000361092 | Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembl [...] |
| TMEM69 protein network | https://string-db.org/network/9606.ENSP00000361095 | Transmembrane protein 69 |
| MMRN2 protein network | https://string-db.org/network/9606.ENSP00000361097 | Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA; EMI domain containing |
| BMPR1A protein network | https://string-db.org/network/9606.ENSP00000361107 | Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phospho [...] |
| GBGT1 protein network | https://string-db.org/network/9606.ENSP00000361110 | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glyc [...] |
| CHRDL1 protein network | https://string-db.org/network/9606.ENSP00000361112 | Chordin-like protein 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurog [...] |
| RALGDS protein network | https://string-db.org/network/9606.ENSP00000361120 | Ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and [...] |
| AKR1A1 protein network | https://string-db.org/network/9606.ENSP00000361140 | Alcohol dehydrogenase [NADP(+)]; Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to [...] |
| OPN4 protein network | https://string-db.org/network/9606.ENSP00000361141 | Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all [...] |
| TMEM164 protein network | https://string-db.org/network/9606.ENSP00000361143 | Transmembrane protein 164; Belongs to the TMEM164 family |
| CEL protein network | https://string-db.org/network/9606.ENSP00000361151 | Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides; Belongs to the type-B ca [...] |
| TESK2 protein network | https://string-db.org/network/9606.ENSP00000361158 | Dual specificity testis-specific protein kinase 2; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and [...] |
| CCSER2 protein network | https://string-db.org/network/9606.ENSP00000361160 | Microtubule-binding protein which might play a role in microtubule bundling |
| TOE1 protein network | https://string-db.org/network/9606.ENSP00000361162 | Target of EGR1 protein 1; Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the matura [...] |
| MUTYH protein network | https://string-db.org/network/9606.ENSP00000361170 | Adenine DNA glycosylase; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adeni [...] |
| KCNE1L protein network | https://string-db.org/network/9606.ENSP00000361173 | Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of [...] |
| LRIT1 protein network | https://string-db.org/network/9606.ENSP00000361177 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction; Fibronectin type III domain containing |
| GTF3C5 protein network | https://string-db.org/network/9606.ENSP00000361180 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly bi [...] |
| TP53RK protein network | https://string-db.org/network/9606.ENSP00000361186 | TP53-regulating kinase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginnin [...] |
| C10orf99 protein network | https://string-db.org/network/9606.ENSP00000361199 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitement to epithelia through binding and activation of the G- protein coupled receptor GPR15. May be a tumor suppressor; together [...] |
| IRS4 protein network | https://string-db.org/network/9606.ENSP00000361202 | Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network o [...] |
| MRPS18A protein network | https://string-db.org/network/9606.ENSP00000361206 | Mitochondrial ribosomal protein S18A; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily |
| GHITM protein network | https://string-db.org/network/9606.ENSP00000361207 | Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c; Transmembrane BAX inhibitor [...] |
| NRG3 protein network | https://string-db.org/network/9606.ENSP00000361214 | Pro-neuregulin-3, membrane-bound isoform; Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does [...] |
| GTF3C4 protein network | https://string-db.org/network/9606.ENSP00000361219 | General transcription factor 3C polypeptide 4; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA [...] |
| DDX31 protein network | https://string-db.org/network/9606.ENSP00000361232 | Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1; Belo [...] |
| RSPH9 protein network | https://string-db.org/network/9606.ENSP00000361238 | Radial spoke head 9 homolog |
| HECTD3 protein network | https://string-db.org/network/9606.ENSP00000361245 | E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted [...] |
| RAPGEF1 protein network | https://string-db.org/network/9606.ENSP00000361263 | Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the estab [...] |
| PTCH2 protein network | https://string-db.org/network/9606.ENSP00000361266 | Protein patched homolog 2; May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH) |
| DYDC2 protein network | https://string-db.org/network/9606.ENSP00000361272 | DPY30 domain containing 2; Belongs to the dpy-30 family |
| PLK3 protein network | https://string-db.org/network/9606.ENSP00000361275 | Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphoryla [...] |
| DYDC1 protein network | https://string-db.org/network/9606.ENSP00000361278 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis |
| BEST4 protein network | https://string-db.org/network/9606.ENSP00000361281 | Bestrophin-4; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins |
| UCK1 protein network | https://string-db.org/network/9606.ENSP00000361285 | Uridine-cytidine kinase 1; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use [...] |
| MAT1A protein network | https://string-db.org/network/9606.ENSP00000361287 | S-adenosylmethionine synthase isoform type-1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: [...] |
| KIF2C protein network | https://string-db.org/network/9606.ENSP00000361298 | Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore [...] |
| POMT1 protein network | https://string-db.org/network/9606.ENSP00000361302 | Protein O-mannosyl-transferase 1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, express [...] |
| ATG4A protein network | https://string-db.org/network/9606.ENSP00000361306 | Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal gl [...] |
| POLH protein network | https://string-db.org/network/9606.ENSP00000361310 | DNA polymerase eta; DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetram [...] |
| TMEM53 protein network | https://string-db.org/network/9606.ENSP00000361311 | Transmembrane protein 53; Belongs to the TMEM53 family |
| ERI3 protein network | https://string-db.org/network/9606.ENSP00000361331 | ERI1 exoribonuclease family member 3; Exonucleases |
| PLAC9 protein network | https://string-db.org/network/9606.ENSP00000361337 | Placenta-specific protein 9; Placenta specific 9; Belongs to the PLAC9 family |
| PPAPDC3 protein network | https://string-db.org/network/9606.ENSP00000361338 | Inactive phospholipid phosphatase 7; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity (By similarity [...] |
| FAM78A protein network | https://string-db.org/network/9606.ENSP00000361345 | Protein FAM78A; Family with sequence similarity 78 member A; Belongs to the FAM78 family |
| TMEM254 protein network | https://string-db.org/network/9606.ENSP00000361355 | Transmembrane protein 254 |
| CD40 protein network | https://string-db.org/network/9606.ENSP00000361359 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction o [...] |
| DMAP1 protein network | https://string-db.org/network/9606.ENSP00000361363 | DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin [...] |
| SFTPD protein network | https://string-db.org/network/9606.ENSP00000361366 | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccha [...] |
| KLF17 protein network | https://string-db.org/network/9606.ENSP00000361373 | Krueppel-like factor 17; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and me [...] |
| AIF1L protein network | https://string-db.org/network/9606.ENSP00000361383 | Allograft inflammatory factor 1 like; EF-hand domain containing |
| CCDC24 protein network | https://string-db.org/network/9606.ENSP00000361392 | Coiled-coil domain containing 24 |
| NUTM2G protein network | https://string-db.org/network/9606.ENSP00000361397 | NUT family member 2G |
| SFTPA2 protein network | https://string-db.org/network/9606.ENSP00000361400 | Pulmonary surfactant-associated protein A2; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveo [...] |
| MMP9 protein network | https://string-db.org/network/9606.ENSP00000361405 | Matrix metalloproteinase-9; May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS [...] |
| ZCCHC24 protein network | https://string-db.org/network/9606.ENSP00000361411 | Zinc finger CCHC-type containing 24; Zinc fingers 3CxxC-type |
| FIBCD1 protein network | https://string-db.org/network/9606.ENSP00000361413 | Fibrinogen C domain-containing protein 1; Acetyl group-binding receptor which shows a high- affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbo [...] |
| IPO13 protein network | https://string-db.org/network/9606.ENSP00000361418 | Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...] |
| ABL1 protein network | https://string-db.org/network/9606.ENSP00000361423 | Tyrosine-protein kinase ABL1; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extrac [...] |
| EXOSC2 protein network | https://string-db.org/network/9606.ENSP00000361433 | Exosome complex component RRP4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...] |
| POLR3A protein network | https://string-db.org/network/9606.ENSP00000361446 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catal [...] |
| TSC22D3 protein network | https://string-db.org/network/9606.ENSP00000361458 | TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apopt [...] |
| POLR1C protein network | https://string-db.org/network/9606.ENSP00000361465 | DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common co [...] |
| DLG5 protein network | https://string-db.org/network/9606.ENSP00000361467 | Disks large homolog 5; Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them togeth [...] |
| ASS1 protein network | https://string-db.org/network/9606.ENSP00000361471 | Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic [...] |
| KDM4A protein network | https://string-db.org/network/9606.ENSP00000361473 | Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethyla [...] |
| NCS1 protein network | https://string-db.org/network/9606.ENSP00000361475 | Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Ca [...] |
| GPR107 protein network | https://string-db.org/network/9606.ENSP00000361483 | Protein GPR107; Involved in Golgi-to-ER retrograde transport. Functions as a host factor required for infection by Pseudomonas aeruginosa exotoxin A and Campylobacter jejuni CDT toxins; Belongs t [...] |
| PCIF1 protein network | https://string-db.org/network/9606.ENSP00000361486 | Phosphorylated CTD-interacting factor 1; May play a role in transcription elongation or in coupling transcription to pre-mRNA processing through its association with the phosphorylated C-terminal [...] |
| YIPF3 protein network | https://string-db.org/network/9606.ENSP00000361499 | Protein YIPF3; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis; Yip1 domain containing |
| HYI protein network | https://string-db.org/network/9606.ENSP00000361502 | Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) |
| PRPS1 protein network | https://string-db.org/network/9606.ENSP00000361512 | Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase f [...] |
| LRRC73 protein network | https://string-db.org/network/9606.ENSP00000361518 | Leucine-rich repeat-containing protein 73; Leucine rich repeat containing 73 |
| TJAP1 protein network | https://string-db.org/network/9606.ENSP00000361522 | Tight junction associated protein 1 |
| C9orf78 protein network | https://string-db.org/network/9606.ENSP00000361524 | Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length; Spliceosomal P complex |
| CDC20 protein network | https://string-db.org/network/9606.ENSP00000361540 | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is r [...] |
| NUP62CL protein network | https://string-db.org/network/9606.ENSP00000361544 | Nucleoporin-62 C-terminal-like protein; Nucleoporin 62 C-terminal like; Belongs to the nucleoporin NSP1/NUP62 family |
| PRRX2 protein network | https://string-db.org/network/9606.ENSP00000361547 | Paired mesoderm homeobox protein 2; May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development; Belongs to the paired homeobox family |
| MPL protein network | https://string-db.org/network/9606.ENSP00000361548 | Thrombopoietin receptor; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses; Belongs to the type I cytokine receptor family. Type 1 sub [...] |
| TIE1 protein network | https://string-db.org/network/9606.ENSP00000361554 | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis |
| C9orf50 protein network | https://string-db.org/network/9606.ENSP00000361556 | Uncharacterized protein C9orf50; Chromosome 9 open reading frame 50 |
| RBM41 protein network | https://string-db.org/network/9606.ENSP00000361557 | RNA-binding protein 41; May bind RNA; RNA binding motif containing |
| CTSA protein network | https://string-db.org/network/9606.ENSP00000361562 | Lysosomal protective protein; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective fu [...] |
| IER5L protein network | https://string-db.org/network/9606.ENSP00000361569 | Immediate early response 5 like |
| C10orf11 protein network | https://string-db.org/network/9606.ENSP00000361577 | Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation |
| ZNF691 protein network | https://string-db.org/network/9606.ENSP00000361580 | Zinc finger protein 691; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ERMAP protein network | https://string-db.org/network/9606.ENSP00000361595 | Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family |
| NEURL2 protein network | https://string-db.org/network/9606.ENSP00000361596 | Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-bo [...] |
| SPATA25 protein network | https://string-db.org/network/9606.ENSP00000361597 | Spermatogenesis-associated protein 25; May play a role in spermatogenesis; Belongs to the SPATA25 family |
| CCDC23 protein network | https://string-db.org/network/9606.ENSP00000361599 | Small vasohibin-binding protein; Enhances the solubility and secretion of VASH1 and prevents its ubiquitination. Also enhances secretion of VASH2 |
| ZSWIM1 protein network | https://string-db.org/network/9606.ENSP00000361601 | Zinc finger SWIM-type containing 1 |
| ZNF503 protein network | https://string-db.org/network/9606.ENSP00000361602 | Zinc finger protein 503; May function as a transcriptional repressor; Zinc fingers C2H2-type |
| C1orf50 protein network | https://string-db.org/network/9606.ENSP00000361603 | Uncharacterized protein C1orf50; Chromosome 1 open reading frame 50 |
| ABCC10 protein network | https://string-db.org/network/9606.ENSP00000361608 | Multidrug resistance-associated protein 7; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion; ATP binding cassette subfamily C |
| COMTD1 protein network | https://string-db.org/network/9606.ENSP00000361616 | Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferas [...] |
| DOLPP1 protein network | https://string-db.org/network/9606.ENSP00000361625 | Dolichyldiphosphatase 1; Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rat [...] |
| YBX1 protein network | https://string-db.org/network/9606.ENSP00000361626 | Nuclease-sensitive element-binding protein 1; Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytopl [...] |
| CXorf57 protein network | https://string-db.org/network/9606.ENSP00000361628 | RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at fork [...] |
| SH3GLB2 protein network | https://string-db.org/network/9606.ENSP00000361634 | Endophilin-B2; SH3 domain containing GRB2 like, endophilin B2 |
| VDAC2 protein network | https://string-db.org/network/9606.ENSP00000361635 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conf [...] |
| TNNC2 protein network | https://string-db.org/network/9606.ENSP00000361636 | Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T whi [...] |
| PPCS protein network | https://string-db.org/network/9606.ENSP00000361642 | Phosphopantothenate--cysteine ligase; Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothe [...] |
| ZMYND12 protein network | https://string-db.org/network/9606.ENSP00000361646 | Zinc finger MYND-type containing 12 |
| CRIP3 protein network | https://string-db.org/network/9606.ENSP00000361650 | Cysteine rich protein 3; LIM domain containing |
| FOXJ3 protein network | https://string-db.org/network/9606.ENSP00000361653 | Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration; Forkhead boxes |
| NUP188 protein network | https://string-db.org/network/9606.ENSP00000361658 | Nucleoporin NUP188 homolog; May function as a component of the nuclear pore complex (NPC); Armadillo-like helical domain containing |
| GUCA2B protein network | https://string-db.org/network/9606.ENSP00000361662 | Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a [...] |
| IL1RAPL2 protein network | https://string-db.org/network/9606.ENSP00000361663 | Interleukin 1 receptor accessory protein like 2; Belongs to the interleukin-1 receptor family |
| HIVEP3 protein network | https://string-db.org/network/9606.ENSP00000361664 | Transcription factor HIVEP3; Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segmen [...] |
| SLC22A7 protein network | https://string-db.org/network/9606.ENSP00000361666 | Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, g [...] |
| DOLK protein network | https://string-db.org/network/9606.ENSP00000361667 | Dolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors |
| EDN2 protein network | https://string-db.org/network/9606.ENSP00000361668 | Endothelin-2; Endothelins are endothelium-derived vasoconstrictor peptides; Endogenous ligands |
| ESX1 protein network | https://string-db.org/network/9606.ENSP00000361669 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arre [...] |
| FOXO6 protein network | https://string-db.org/network/9606.ENSP00000361672 | Forkhead box protein O6; Transcriptional activator; Forkhead boxes |
| GLRA4 protein network | https://string-db.org/network/9606.ENSP00000361700 | Glycine receptor subunit alpha-4; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and bet [...] |
| CTPS1 protein network | https://string-db.org/network/9606.ENSP00000361704 | CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP- dependent amination of UTP to CTP with either L-glutamine or [...] |
| DNTTIP1 protein network | https://string-db.org/network/9606.ENSP00000361705 | Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the conse [...] |
| TCEAL1 protein network | https://string-db.org/network/9606.ENSP00000361708 | Transcription elongation factor A like family |
| TCEAL3 protein network | https://string-db.org/network/9606.ENSP00000361711 | Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Transcription elongation factor A like family |
| TCEAL4 protein network | https://string-db.org/network/9606.ENSP00000361712 | Transcription elongation factor A protein-like 4; May be involved in transcriptional regulation; Transcription elongation factor A like family |
| RAB40A protein network | https://string-db.org/network/9606.ENSP00000361716 | Ras-related protein Rab-40A; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...] |
| CITED4 protein network | https://string-db.org/network/9606.ENSP00000361721 | Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor [...] |
| ENDOG protein network | https://string-db.org/network/9606.ENSP00000361725 | Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase [...] |
| WFDC10A protein network | https://string-db.org/network/9606.ENSP00000361726 | WAP four-disulfide core domain containing |
| NGFRAP1 protein network | https://string-db.org/network/9606.ENSP00000361728 | Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity). May play an important role [...] |
| TBC1D13 protein network | https://string-db.org/network/9606.ENSP00000361731 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to [...] |
| WFDC8 protein network | https://string-db.org/network/9606.ENSP00000361735 | WAP four-disulfide core domain containing |
| WBP5 protein network | https://string-db.org/network/9606.ENSP00000361745 | Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation |
| EPPIN protein network | https://string-db.org/network/9606.ENSP00000361746 | Eppin; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides antimicrobial protect [...] |
| ZDHHC12 protein network | https://string-db.org/network/9606.ENSP00000361748 | Probable palmitoyltransferase ZDHHC12; Zinc finger DHHC-type containing 12; Belongs to the DHHC palmitoyltransferase family |
| WFDC6 protein network | https://string-db.org/network/9606.ENSP00000361755 | WAP four-disulfide core domain containing |
| WFDC2 protein network | https://string-db.org/network/9606.ENSP00000361761 | WAP four-disulfide core domain protein 2; Broad range protease inhibitor; WAP four-disulfide core domain containing |
| TCEAL5 protein network | https://string-db.org/network/9606.ENSP00000361765 | Transcription elongation factor A protein-like 5; May be involved in transcriptional regulation; Transcription elongation factor A like family |
| RIMS3 protein network | https://string-db.org/network/9606.ENSP00000361769 | Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis |
| TCEAL8 protein network | https://string-db.org/network/9606.ENSP00000361770 | Transcription elongation factor A protein-like 8; May be involved in transcriptional regulation; Transcription elongation factor A like family |
| SET protein network | https://string-db.org/network/9606.ENSP00000361777 | Protein SET; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activ [...] |
| BEX4 protein network | https://string-db.org/network/9606.ENSP00000361780 | Protein BEX4; May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha- tubulin and thereby participate to the control of cell cycle progr [...] |
| ZNF684 protein network | https://string-db.org/network/9606.ENSP00000361784 | Zinc finger protein 684; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DUSP13 protein network | https://string-db.org/network/9606.ENSP00000361785 | Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activi [...] |
| EXO5 protein network | https://string-db.org/network/9606.ENSP00000361788 | Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (IC [...] |
| ZFP69 protein network | https://string-db.org/network/9606.ENSP00000361791 | Zinc finger protein ZFP69; May be involved in transcriptional regulation; SCAN domain containing |
| DBNDD2 protein network | https://string-db.org/network/9606.ENSP00000361795 | Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro); Belongs to the dysbindin family |
| WDR34 protein network | https://string-db.org/network/9606.ENSP00000361800 | WD repeat-containing protein 34; Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-b [...] |
| SMAP2 protein network | https://string-db.org/network/9606.ENSP00000361803 | Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endoso [...] |
| TP53TG5 protein network | https://string-db.org/network/9606.ENSP00000361811 | TP53-target gene 5 protein; May play a significant role in p53/TP53-mediating signaling pathway |
| BEX1 protein network | https://string-db.org/network/9606.ENSP00000361813 | Protein BEX1; Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to n [...] |
| SDC4 protein network | https://string-db.org/network/9606.ENSP00000361818 | Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP; Belongs to the syndecan proteoglycan family |
| BHLHB9 protein network | https://string-db.org/network/9606.ENSP00000361820 | Protein BHLHb9; May play a role in the control of cellular aging and survival; Armadillo repeat containing |
| SPTAN1 protein network | https://string-db.org/network/9606.ENSP00000361824 | Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent [...] |
| COL9A2 protein network | https://string-db.org/network/9606.ENSP00000361834 | Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye; Collagen proteoglycans |
| MATN4 protein network | https://string-db.org/network/9606.ENSP00000361842 | Matrilin-4; Major component of the extracellular matrix of cartilage; Matrilins |
| ZMPSTE24 protein network | https://string-db.org/network/9606.ENSP00000361845 | CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C |
| PLAU protein network | https://string-db.org/network/9606.ENSP00000361850 | Urokinase-type plasminogen activator; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin |
| TMCO2 protein network | https://string-db.org/network/9606.ENSP00000361852 | Transmembrane and coiled-coil domains 2 |
| SEMG2 protein network | https://string-db.org/network/9606.ENSP00000361855 | Semenogelin-2; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa |
| RLF protein network | https://string-db.org/network/9606.ENSP00000361857 | Zinc finger protein Rlf; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TCEAL6 protein network | https://string-db.org/network/9606.ENSP00000361860 | Transcription elongation factor A like family |
| TCEAL2 protein network | https://string-db.org/network/9606.ENSP00000361866 | Transcription elongation factor A protein-like 2; May be involved in transcriptional regulation; Transcription elongation factor A like family |
| SEMG1 protein network | https://string-db.org/network/9606.ENSP00000361867 | Semenogelin-1; Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or [...] |
| ZMAT1 protein network | https://string-db.org/network/9606.ENSP00000361868 | Zinc finger matrin-type 1 |
| WFDC12 protein network | https://string-db.org/network/9606.ENSP00000361871 | WAP four-disulfide core domain protein 12; Antibacterial protein. Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing |
| WFDC5 protein network | https://string-db.org/network/9606.ENSP00000361875 | WAP four-disulfide core domain protein 5; Putative acid-stable proteinase inhibitor; WAP four-disulfide core domain containing |
| CAP1 protein network | https://string-db.org/network/9606.ENSP00000361883 | Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization a [...] |
| STK4 protein network | https://string-db.org/network/9606.ENSP00000361892 | Serine/threonine-protein kinase 4; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA [...] |
| GNMT protein network | https://string-db.org/network/9606.ENSP00000361894 | Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocyst [...] |
| MFSD2A protein network | https://string-db.org/network/9606.ENSP00000361895 | Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function (By si [...] |
| TOMM34 protein network | https://string-db.org/network/9606.ENSP00000361900 | Mitochondrial import receptor subunit TOM34; Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with [...] |
| OXCT2 protein network | https://string-db.org/network/9606.ENSP00000361914 | Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA interm [...] |
| BMP8B protein network | https://string-db.org/network/9606.ENSP00000361915 | Bone morphogenetic protein 8B; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...] |
| ARMCX1 protein network | https://string-db.org/network/9606.ENSP00000361917 | Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria i [...] |
| PPIE protein network | https://string-db.org/network/9606.ENSP00000361918 | Peptidyl-prolyl cis-trans isomerase E; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Combines RNA-binding [...] |
| CHCHD1 protein network | https://string-db.org/network/9606.ENSP00000361923 | Mitochondrial coiled-coil-helix-coiled-coil-helix domain containing proteins |
| CNPY3 protein network | https://string-db.org/network/9606.ENSP00000361926 | Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticu [...] |
| HNRNPH2 protein network | https://string-db.org/network/9606.ENSP00000361927 | Heterogeneous nuclear ribonucleoprotein H2; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that [...] |
| CERCAM protein network | https://string-db.org/network/9606.ENSP00000361929 | Inactive glycosyltransferase 25 family member 3; Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferas [...] |
| YWHAB protein network | https://string-db.org/network/9606.ENSP00000361930 | 14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by rec [...] |
| FUT11 protein network | https://string-db.org/network/9606.ENSP00000361932 | Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Fucosyltransferases |
| HPCAL4 protein network | https://string-db.org/network/9606.ENSP00000361935 | Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; EF-hand domain containing |
| HEYL protein network | https://string-db.org/network/9606.ENSP00000361943 | Hairy/enhancer-of-split related with YRPW motif-like protein; Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional represso [...] |
| PABPC4 protein network | https://string-db.org/network/9606.ENSP00000361949 | Polyadenylate-binding protein 4; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than [...] |
| KCNK15 protein network | https://string-db.org/network/9606.ENSP00000361952 | Potassium channel subfamily K member 15; Probable potassium channel subunit. No channel activity observed in heterologous systems. May need to associate with another protein to form a functional [...] |
| WISP2 protein network | https://string-db.org/network/9606.ENSP00000361959 | WNT1-inducible-signaling pathway protein 2; May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin re [...] |
| ADA protein network | https://string-db.org/network/9606.ENSP00000361965 | Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by ext [...] |
| TBCC protein network | https://string-db.org/network/9606.ENSP00000361967 | Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway; Belongs to the TBCC family |
| PKIG protein network | https://string-db.org/network/9606.ENSP00000361980 | cAMP-dependent protein kinase inhibitor gamma; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme af [...] |
| TRUB2 protein network | https://string-db.org/network/9606.ENSP00000361982 | Mitochondrial mRNA pseudouridine synthase TRUB2; Minor enzyme contributing to the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at position [...] |
| UBR2 protein network | https://string-db.org/network/9606.ENSP00000361990 | E3 ubiquitin-protein ligase UBR2; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destab [...] |
| TIMM8A protein network | https://string-db.org/network/9606.ENSP00000361993 | Mitochondrial import inner membrane translocase subunit Tim8 A; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into [...] |
| TTPAL protein network | https://string-db.org/network/9606.ENSP00000361995 | Alpha-tocopherol transfer protein-like; May act as a protein that binds a hydrophobic ligand |
| TAF7L protein network | https://string-db.org/network/9606.ENSP00000361998 | Transcription initiation factor TFIID subunit 7-like; Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein [...] |
| ANXA7 protein network | https://string-db.org/network/9606.ENSP00000362010 | Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family |
| DNM1 protein network | https://string-db.org/network/9606.ENSP00000362014 | Dynamin-1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. [...] |
| CENPI protein network | https://string-db.org/network/9606.ENSP00000362018 | Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...] |
| TMEM35 protein network | https://string-db.org/network/9606.ENSP00000362021 | Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth |
| TRMT2B protein network | https://string-db.org/network/9606.ENSP00000362027 | tRNA (uracil(54)-C(5))-methyltransferase homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. [...] |
| MRPS16 protein network | https://string-db.org/network/9606.ENSP00000362036 | Mitochondrial ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family |
| DNAJC9 protein network | https://string-db.org/network/9606.ENSP00000362041 | DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8; DNAJ heat shock proteins |
| XKRX protein network | https://string-db.org/network/9606.ENSP00000362047 | XK-related protein 2; XK related, X-linked |
| LOC114841037 protein network | https://string-db.org/network/9606.ENSP00000362054 | annotation not available |
| NOX1 protein network | https://string-db.org/network/9606.ENSP00000362057 | NADPH oxidase 1; NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked [...] |
| NDUFS5 protein network | https://string-db.org/network/9606.ENSP00000362060 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in cat [...] |
| OSER1 protein network | https://string-db.org/network/9606.ENSP00000362061 | Oxidative stress-responsive serine-rich protein 1; Oxidative stress responsive serine rich 1 |
| CSTF2 protein network | https://string-db.org/network/9606.ENSP00000362063 | Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre [...] |
| TAF8 protein network | https://string-db.org/network/9606.ENSP00000362068 | Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal [...] |
| JPH2 protein network | https://string-db.org/network/9606.ENSP00000362071 | Junctophilin-2; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...] |
| SYTL4 protein network | https://string-db.org/network/9606.ENSP00000362080 | Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phosph [...] |
| CCND3 protein network | https://string-db.org/network/9606.ENSP00000362082 | G1/S-specific cyclin-D3; Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the [...] |
| C9orf16 protein network | https://string-db.org/network/9606.ENSP00000362085 | UPF0184 protein C9orf16; Chromosome 9 open reading frame 16 |
| RRAGC protein network | https://string-db.org/network/9606.ENSP00000362092 | Ras-related GTP-binding protein C; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its sub [...] |
| GTSF1L protein network | https://string-db.org/network/9606.ENSP00000362094 | Gametocyte-specific factor 1-like; Gametocyte specific factor 1 like |
| SRPX2 protein network | https://string-db.org/network/9606.ENSP00000362095 | Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the forma [...] |
| POU3F1 protein network | https://string-db.org/network/9606.ENSP00000362103 | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis; POU class homeo [...] |
| UTP11L protein network | https://string-db.org/network/9606.ENSP00000362105 | Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA |
| FHL3 protein network | https://string-db.org/network/9606.ENSP00000362107 | Four and a half LIM domains 3 |
| LCN2 protein network | https://string-db.org/network/9606.ENSP00000362108 | Neutrophil gelatinase-associated lipocalin; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2 [...] |
| FRS3 protein network | https://string-db.org/network/9606.ENSP00000362109 | Fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 si [...] |
| SF3A3 protein network | https://string-db.org/network/9606.ENSP00000362110 | Splicing factor 3A subunit 3; Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequenc [...] |
| TSPAN6 protein network | https://string-db.org/network/9606.ENSP00000362111 | Tetraspanin-6; Tetraspanin 6; Tetraspanins |
| INPP5B protein network | https://string-db.org/network/9606.ENSP00000362115 | Type II inositol 1,4,5-trisphosphate 5-phosphatase; Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4, [...] |
| PGC protein network | https://string-db.org/network/9606.ENSP00000362116 | Gastricsin; Hydrolyzes a variety of proteins; Belongs to the peptidase A1 family |
| IFT52 protein network | https://string-db.org/network/9606.ENSP00000362121 | Intraflagellar transport protein 52 homolog; Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the as [...] |
| TNMD protein network | https://string-db.org/network/9606.ENSP00000362122 | Tenomodulin; May be an angiogenesis inhibitor; BRICHOS domain containing |
| PLA2G12B protein network | https://string-db.org/network/9606.ENSP00000362123 | Group XIIB secretory phospholipase A2-like protein; Not known; does not seem to have catalytic activity; Phospholipases |
| PCDH19 protein network | https://string-db.org/network/9606.ENSP00000362125 | Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| MTF1 protein network | https://string-db.org/network/9606.ENSP00000362127 | Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE) |
| RPA4 protein network | https://string-db.org/network/9606.ENSP00000362131 | Replication protein A 30 kDa subunit; As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. Compared to the RPA2-conta [...] |
| C1orf122 protein network | https://string-db.org/network/9606.ENSP00000362133 | Uncharacterized protein C1orf122; Chromosome 1 open reading frame 122 |
| YRDC protein network | https://string-db.org/network/9606.ENSP00000362135 | YrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters; Belongs to the SUA5 family |
| MANEAL protein network | https://string-db.org/network/9606.ENSP00000362136 | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family |
| EPHA10 protein network | https://string-db.org/network/9606.ENSP00000362139 | Ephrin type-A receptor 10; Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 |
| MCU protein network | https://string-db.org/network/9606.ENSP00000362144 | Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subuni [...] |
| CDCA8 protein network | https://string-db.org/network/9606.ENSP00000362146 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct ch [...] |
| FOXP4 protein network | https://string-db.org/network/9606.ENSP00000362151 | Forkhead box protein P4; Transcriptional repressor that represses lung-specific expression; Forkhead boxes |
| GNL2 protein network | https://string-db.org/network/9606.ENSP00000362153 | Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
| SLC25A25 protein network | https://string-db.org/network/9606.ENSP00000362159 | Calcium-binding mitochondrial carrier protein SCaMC-2; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mi [...] |
| MEAF6 protein network | https://string-db.org/network/9606.ENSP00000362166 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of [...] |
| NAIF1 protein network | https://string-db.org/network/9606.ENSP00000362170 | Nuclear apoptosis-inducing factor 1; Induces apoptosis; Belongs to the NAIF1 family |
| NAP1L3 protein network | https://string-db.org/network/9606.ENSP00000362171 | Nucleosome assembly protein 1 like 3 |
| ZC3H12A protein network | https://string-db.org/network/9606.ENSP00000362179 | Endoribonuclease ZC3H12A; Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, [...] |
| NCR2 protein network | https://string-db.org/network/9606.ENSP00000362181 | Natural cytotoxicity triggering receptor 2; Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis |
| GRIK3 protein network | https://string-db.org/network/9606.ENSP00000362183 | Glutamate receptor ionotropic, kainate 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transm [...] |
| PCDH11X protein network | https://string-db.org/network/9606.ENSP00000362186 | Protocadherin-11 X-linked; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| FAM102A protein network | https://string-db.org/network/9606.ENSP00000362187 | Protein FAM102A; May play a role in estrogen action; Belongs to the FAM102 family |
| CSF3R protein network | https://string-db.org/network/9606.ENSP00000362195 | Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differ [...] |
| SPOCK2 protein network | https://string-db.org/network/9606.ENSP00000362201 | Testican-2; May participate in diverse steps of neurogenesis. Binds calcium; SPARC family |
| TREM2 protein network | https://string-db.org/network/9606.ENSP00000362205 | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a rol [...] |
| KLHL4 protein network | https://string-db.org/network/9606.ENSP00000362206 | Kelch-like protein 4; Kelch like family member 4; BTB domain containing |
| CHST3 protein network | https://string-db.org/network/9606.ENSP00000362207 | Carbohydrate sulfotransferase 3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosa [...] |
| MRPS15 protein network | https://string-db.org/network/9606.ENSP00000362208 | Mitochondrial ribosomal protein S15; Belongs to the universal ribosomal protein uS15 family |
| DACH2 protein network | https://string-db.org/network/9606.ENSP00000362217 | Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating prolifera [...] |
| STK40 protein network | https://string-db.org/network/9606.ENSP00000362222 | Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53- mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family |
| ST6GALNAC6 protein network | https://string-db.org/network/9606.ENSP00000362235 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; Sialyltransferases |
| MAP7D1 protein network | https://string-db.org/network/9606.ENSP00000362244 | MAP7 domain containing 1; Belongs to the MAP7 family |
| TSPO2 protein network | https://string-db.org/network/9606.ENSP00000362255 | Translocator protein 2; Binds cholesterol and mediates its redistribution during erythropoiesis which may play a role in erythrocyte maturation |
| ZNF711 protein network | https://string-db.org/network/9606.ENSP00000362260 | Zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demet [...] |
| APOOL protein network | https://string-db.org/network/9606.ENSP00000362268 | MICOS complex subunit MIC27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| AK1 protein network | https://string-db.org/network/9606.ENSP00000362271 | Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important [...] |
| ADPRHL2 protein network | https://string-db.org/network/9606.ENSP00000362273 | Poly(ADP-ribose) glycohydrolase ARH3; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabo [...] |
| MOCS1 protein network | https://string-db.org/network/9606.ENSP00000362282 | Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A c [...] |
| SLC29A3 protein network | https://string-db.org/network/9606.ENSP00000362285 | Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as we [...] |
| AGO3 protein network | https://string-db.org/network/9606.ENSP00000362287 | Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks [...] |
| PTPRT protein network | https://string-db.org/network/9606.ENSP00000362294 | Receptor-type tyrosine-protein phosphatase T; May be involved in both signal transduction and cellular adhesion in the CNS; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B s [...] |
| POU3F4 protein network | https://string-db.org/network/9606.ENSP00000362296 | POU domain, class 3, transcription factor 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature [...] |
| SGPL1 protein network | https://string-db.org/network/9606.ENSP00000362298 | Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide pro [...] |
| ENG protein network | https://string-db.org/network/9606.ENSP00000362299 | Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migrati [...] |
| AGO1 protein network | https://string-db.org/network/9606.ENSP00000362300 | Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs whi [...] |
| ADAMTS14 protein network | https://string-db.org/network/9606.ENSP00000362304 | A disintegrin and metalloproteinase with thrombospondin motifs 14; Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme [...] |
| AGO4 protein network | https://string-db.org/network/9606.ENSP00000362306 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks [...] |
| SH3BGRL protein network | https://string-db.org/network/9606.ENSP00000362308 | SH3 domain-binding glutamic acid-rich-like protein; SH3 domain binding glutamate rich protein like |
| EIF4EBP2 protein network | https://string-db.org/network/9606.ENSP00000362314 | Eukaryotic translation initiation factor 4E-binding protein 2; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E [...] |
| KCNK17 protein network | https://string-db.org/network/9606.ENSP00000362328 | Potassium channel subfamily K member 17; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel [...] |
| PPA1 protein network | https://string-db.org/network/9606.ENSP00000362329 | Pyrophosphatase 1 |
| CHD6 protein network | https://string-db.org/network/9606.ENSP00000362330 | Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner whic [...] |
| TFAP2E protein network | https://string-db.org/network/9606.ENSP00000362332 | Transcription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 facto [...] |
| PSMB2 protein network | https://string-db.org/network/9606.ENSP00000362334 | Proteasome subunit beta type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| SAR1A protein network | https://string-db.org/network/9606.ENSP00000362339 | GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER me [...] |
| NCDN protein network | https://string-db.org/network/9606.ENSP00000362340 | Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required [...] |
| FPGS protein network | https://string-db.org/network/9606.ENSP00000362344 | Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of [...] |
| H2AFY2 protein network | https://string-db.org/network/9606.ENSP00000362352 | Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limitin [...] |
| GLP1R protein network | https://string-db.org/network/9606.ENSP00000362353 | Glucagon-like peptide 1 receptor; G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenyly [...] |
| LPIN3 protein network | https://string-db.org/network/9606.ENSP00000362354 | Phosphatidate phosphatase LPIN3; Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during [...] |
| CDK9 protein network | https://string-db.org/network/9606.ENSP00000362361 | Cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elong [...] |
| BRWD3 protein network | https://string-db.org/network/9606.ENSP00000362372 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape; Bromodomain containing |
| C10orf35 protein network | https://string-db.org/network/9606.ENSP00000362376 | Uncharacterized protein FAM241B; Chromosome 10 open reading frame 35 |
| TOR2A protein network | https://string-db.org/network/9606.ENSP00000362381 | Torsin-2A; Torsin family 2 member A; Belongs to the ClpA/ClpB family. Torsin subfamily |
| TTC16 protein network | https://string-db.org/network/9606.ENSP00000362386 | Tetratricopeptide repeat domain containing |
| TSPAN15 protein network | https://string-db.org/network/9606.ENSP00000362387 | Tetraspanin-15; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity pro [...] |
| TBX22 protein network | https://string-db.org/network/9606.ENSP00000362390 | T-box transcription factor TBX22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis; T-boxes |
| C9orf117 protein network | https://string-db.org/network/9606.ENSP00000362392 | Cilia- and flagella-associated protein 157; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary [...] |
| ITM2A protein network | https://string-db.org/network/9606.ENSP00000362395 | Integral membrane protein 2A; BRICHOS domain containing |
| STXBP1 protein network | https://string-db.org/network/9606.ENSP00000362399 | Syntaxin-binding protein 1; May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and b [...] |
| TACR2 protein network | https://string-db.org/network/9606.ENSP00000362403 | Substance-K receptor; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger [...] |
| FAM129B protein network | https://string-db.org/network/9606.ENSP00000362409 | Niban-like protein 1; May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro |
| MAFB protein network | https://string-db.org/network/9606.ENSP00000362410 | Transcription factor MafB; Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage- specific hematopoiesis by repressing ETS1-mediated transcription of erythr [...] |
| PGK1 protein network | https://string-db.org/network/9606.ENSP00000362413 | Phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm m [...] |
| TRAF3IP1 protein network | https://string-db.org/network/9606.ENSP00000362424 | TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-bind [...] |
| ZMYM6NB protein network | https://string-db.org/network/9606.ENSP00000362435 | Transmembrane protein 35B; ZMYM6 neighbor |
| ATRX protein network | https://string-db.org/network/9606.ENSP00000362441 | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replic [...] |
| ARHGAP40 protein network | https://string-db.org/network/9606.ENSP00000362442 | Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state |
| DLGAP3 protein network | https://string-db.org/network/9606.ENSP00000362444 | Disks large-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...] |
| ZNF79 protein network | https://string-db.org/network/9606.ENSP00000362446 | Zinc finger protein 79; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PBDC1 protein network | https://string-db.org/network/9606.ENSP00000362456 | Protein PBDC1; Polysaccharide biosynthesis domain containing 1; Belongs to the PBDC1 family |
| MAGEE2 protein network | https://string-db.org/network/9606.ENSP00000362457 | Melanoma-associated antigen E2; MAGE family member E2 |
| GLO1 protein network | https://string-db.org/network/9606.ENSP00000362463 | Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional [...] |
| GJB3 protein network | https://string-db.org/network/9606.ENSP00000362464 | Gap junction beta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| ZDHHC15 protein network | https://string-db.org/network/9606.ENSP00000362465 | Palmitoyltransferase ZDHHC15; Palmitoyltransferase specific for GAP43 and DLG4/PSD95; Belongs to the DHHC palmitoyltransferase family |
| SLC2A8 protein network | https://string-db.org/network/9606.ENSP00000362469 | Solute carrier family 2, facilitated glucose transporter member 8; Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-spe [...] |
| CSMD2 protein network | https://string-db.org/network/9606.ENSP00000362479 | CUB and Sushi multiple domains 2 |
| VPS26A protein network | https://string-db.org/network/9606.ENSP00000362480 | Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...] |
| UPRT protein network | https://string-db.org/network/9606.ENSP00000362481 | Uracil phosphoribosyltransferase homolog; Belongs to the UPRTase family |
| GARNL3 protein network | https://string-db.org/network/9606.ENSP00000362485 | GTPase-activating Rap/Ran-GAP domain-like protein 3; GTPase activating Rap/RanGAP domain like 3 |
| CCDC167 protein network | https://string-db.org/network/9606.ENSP00000362507 | Coiled-coil domain containing 167 |
| UGT1A4 protein network | https://string-db.org/network/9606.ENSP00000362508 | UDP-glucuronosyltransferase 1-4; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates [...] |
| UGT1A5 protein network | https://string-db.org/network/9606.ENSP00000362513 | UDP-glucuronosyltransferase 1-5; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...] |
| ANGPTL2 protein network | https://string-db.org/network/9606.ENSP00000362524 | Angiopoietin-related protein 2; Induces sprouting in endothelial cells through an autocrine and paracrine action; Angiopoietin like |
| UGT1A7 protein network | https://string-db.org/network/9606.ENSP00000362525 | UDP-glucuronosyltransferase 1-7; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...] |
| RPRD1B protein network | https://string-db.org/network/9606.ENSP00000362532 | Regulation of nuclear pre-mRNA domain-containing protein 1B; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and partici [...] |
| TTI1 protein network | https://string-db.org/network/9606.ENSP00000362547 | TELO2-interacting protein 1 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related [...] |
| UGT1A1 protein network | https://string-db.org/network/9606.ENSP00000362549 | UDP-glucuronosyltransferase 1-8; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates [...] |
| CMTR1 protein network | https://string-db.org/network/9606.ENSP00000362550 | Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Met [...] |
| ZBTB34 protein network | https://string-db.org/network/9606.ENSP00000362551 | Zinc finger and BTB domain-containing protein 34; May be a transcriptional repressor; BTB domain containing |
| RNF19B protein network | https://string-db.org/network/9606.ENSP00000362555 | E3 ubiquitin-protein ligase RNF19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transf [...] |
| VSTM2L protein network | https://string-db.org/network/9606.ENSP00000362560 | V-set and transmembrane domain-containing protein 2-like protein; V-set and transmembrane domain containing 2 like |
| TMEM54 protein network | https://string-db.org/network/9606.ENSP00000362562 | Transmembrane protein 54 |
| ZBTB43 protein network | https://string-db.org/network/9606.ENSP00000362563 | Zinc finger and BTB domain-containing protein 43; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| HPCA protein network | https://string-db.org/network/9606.ENSP00000362566 | Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotid [...] |
| FNDC5 protein network | https://string-db.org/network/9606.ENSP00000362570 | Fibronectin type III domain-containing protein 5; Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white ad [...] |
| S100PBP protein network | https://string-db.org/network/9606.ENSP00000362574 | S100P binding protein |
| YARS protein network | https://string-db.org/network/9606.ENSP00000362576 | Tyrosine--tRNA ligase, cytoplasmic; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the accep [...] |
| RNF8 protein network | https://string-db.org/network/9606.ENSP00000362578 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'- linked ubiquitination of histones H2A [...] |
| PBX3 protein network | https://string-db.org/network/9606.ENSP00000362588 | Pre-B-cell leukemia transcription factor 3; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'; TALE class homeoboxes and pseudogenes |
| TBC1D22B protein network | https://string-db.org/network/9606.ENSP00000362590 | TBC1 domain family member 22B; May act as a GTPase-activating protein for Rab family protein(s) |
| RBBP4 protein network | https://string-db.org/network/9606.ENSP00000362592 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a mann [...] |
| CHIC1 protein network | https://string-db.org/network/9606.ENSP00000362601 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family |
| PIM1 protein network | https://string-db.org/network/9606.ENSP00000362608 | Serine/threonine-protein kinase pim-1; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigene [...] |
| ZBTB8A protein network | https://string-db.org/network/9606.ENSP00000362609 | Zinc finger and BTB domain-containing protein 8A; May be involved in transcriptional regulation; BTB domain containing |
| CDX4 protein network | https://string-db.org/network/9606.ENSP00000362613 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family |
| NAP1L2 protein network | https://string-db.org/network/9606.ENSP00000362616 | Nucleosome assembly protein 1-like 2; Acidic protein which may be involved in interactions with other proteins or DNA; Belongs to the nucleosome assembly protein (NAP) family |
| NAP1L6 protein network | https://string-db.org/network/9606.ENSP00000362617 | Nucleosome assembly protein 1 like 6; Belongs to the nucleosome assembly protein (NAP) family |
| PABPC1L2A protein network | https://string-db.org/network/9606.ENSP00000362618 | poly(A) binding protein cytoplasmic 1 like 2A; RNA binding motif containing |
| PABPC1L2B protein network | https://string-db.org/network/9606.ENSP00000362621 | poly(A) binding protein cytoplasmic 1 like 2B; RNA binding motif containing |
| TSSK3 protein network | https://string-db.org/network/9606.ENSP00000362634 | Testis-specific serine/threonine-protein kinase 3; May be involved in a signaling pathway during male germ cell development or mature sperm function |
| MARCKSL1 protein network | https://string-db.org/network/9606.ENSP00000362638 | MARCKS-related protein; Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phospho [...] |
| RABEPK protein network | https://string-db.org/network/9606.ENSP00000362639 | Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport |
| PHKA1 protein network | https://string-db.org/network/9606.ENSP00000362643 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha cha [...] |
| HDAC1 protein network | https://string-db.org/network/9606.ENSP00000362649 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| SCAI protein network | https://string-db.org/network/9606.ENSP00000362650 | Protein SCAI; Tumor suppressor which functions to suppress MKL1- induced SRF transcriptional activity. May function in the RHOA- DIAPH1 signal transduction pathway and regulate cell migration thr [...] |
| GOLGA1 protein network | https://string-db.org/network/9606.ENSP00000362656 | Golgin subfamily A member 1; Probably involved in maintaining Golgi structure |
| HDAC8 protein network | https://string-db.org/network/9606.ENSP00000362674 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| SRC protein network | https://string-db.org/network/9606.ENSP00000362680 | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response [...] |
| OLFML2A protein network | https://string-db.org/network/9606.ENSP00000362682 | Olfactomedin-like protein 2A; Olfactomedin like 2A |
| FAM167B protein network | https://string-db.org/network/9606.ENSP00000362684 | Protein FAM167B; Family with sequence similarity 167 member B; Belongs to the FAM167 (SEC) family |
| DDX50 protein network | https://string-db.org/network/9606.ENSP00000362687 | ATP-dependent RNA helicase DDX50; DExD-box helicase 50; DEAD-box helicases |
| EIF3I protein network | https://string-db.org/network/9606.ENSP00000362688 | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| NR5A1 protein network | https://string-db.org/network/9606.ENSP00000362690 | Steroidogenic factor 1; Transcriptional activator. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of s [...] |
| NEK6 protein network | https://string-db.org/network/9606.ENSP00000362702 | Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase-anaphase transition, robust [...] |
| MANBAL protein network | https://string-db.org/network/9606.ENSP00000362707 | Protein MANBAL; Mannosidases type beta; Belongs to the UPF0239 family |
| COPS7B protein network | https://string-db.org/network/9606.ENSP00000362710 | COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| TXLNA protein network | https://string-db.org/network/9606.ENSP00000362711 | Alpha-taxilin; May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells; Belongs to the taxilin family |
| GHRH protein network | https://string-db.org/network/9606.ENSP00000362716 | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family |
| LHX2 protein network | https://string-db.org/network/9606.ENSP00000362717 | LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differen [...] |
| DENND1A protein network | https://string-db.org/network/9606.ENSP00000362727 | DENN domain-containing protein 1A; Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inac [...] |
| KPNA6 protein network | https://string-db.org/network/9606.ENSP00000362728 | Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| MTCH1 protein network | https://string-db.org/network/9606.ENSP00000362730 | Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis; Solute carriers |
| CRB2 protein network | https://string-db.org/network/9606.ENSP00000362734 | Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move insid [...] |
| C2orf72 protein network | https://string-db.org/network/9606.ENSP00000362743 | Uncharacterized protein C2orf72; Chromosome 2 open reading frame 72 |
| RPS4X protein network | https://string-db.org/network/9606.ENSP00000362744 | Ribosomal protein S4, X-linked; Belongs to the eukaryotic ribosomal protein eS4 family |
| GPR21 protein network | https://string-db.org/network/9606.ENSP00000362746 | Probable G-protein coupled receptor 21; Orphan receptor; G protein-coupled receptors, Class A orphans |
| TET1 protein network | https://string-db.org/network/9606.ENSP00000362748 | Methylcytosine dioxygenase TET1; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active [...] |
| RABGAP1 protein network | https://string-db.org/network/9606.ENSP00000362751 | Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in [...] |
| BAI2 protein network | https://string-db.org/network/9606.ENSP00000362759 | Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT- signaling pathway, a transcription fact [...] |
| ZBTB26 protein network | https://string-db.org/network/9606.ENSP00000362760 | Zinc finger and BTB domain-containing protein 26; May be involved in transcriptional regulation; BTB domain containing |
| ZBTB6 protein network | https://string-db.org/network/9606.ENSP00000362763 | Zinc finger and BTB domain-containing protein 6; May be involved in transcriptional regulation; BTB domain containing |
| RBL1 protein network | https://string-db.org/network/9606.ENSP00000362768 | Retinoblastoma-like protein 1; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of con [...] |
| PIN4 protein network | https://string-db.org/network/9606.ENSP00000362773 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-strand [...] |
| RC3H2 protein network | https://string-db.org/network/9606.ENSP00000362774 | Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, [...] |
| COL16A1 protein network | https://string-db.org/network/9606.ENSP00000362776 | Collagen alpha-1(XVI) chain; Involved in mediating cell attachment and inducing integrin-mediated cellular reactions, such as cell spreading and alterations in cell morphology; Collagens |
| ATOH7 protein network | https://string-db.org/network/9606.ENSP00000362777 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells; Basic helix-loop-helix proteins |
| PI16 protein network | https://string-db.org/network/9606.ENSP00000362778 | Peptidase inhibitor 16; May inhibit cardiomyocyte growth; CAP superfamily |
| OR5C1 protein network | https://string-db.org/network/9606.ENSP00000362784 | Olfactory receptor 5C1; Odorant receptor; Olfactory receptors, family 5 |
| OR1N2 protein network | https://string-db.org/network/9606.ENSP00000362792 | Olfactory receptor 1N2; Odorant receptor; Olfactory receptors, family 1 |
| CXCR3 protein network | https://string-db.org/network/9606.ENSP00000362795 | C-X-C chemokine receptor type 3; Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HM [...] |
| ACRC protein network | https://string-db.org/network/9606.ENSP00000362799 | Acidic repeat-containing protein; Acidic repeat containing; Belongs to the serine-aspartate repeat-containing protein (SDr) family |
| PPIL1 protein network | https://string-db.org/network/9606.ENSP00000362803 | Peptidyl-prolyl cis-trans isomerase-like 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved [...] |
| PEF1 protein network | https://string-db.org/network/9606.ENSP00000362807 | Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-d [...] |
| SERINC2 protein network | https://string-db.org/network/9606.ENSP00000362814 | Serine incorporator 2; Belongs to the TDE1 family |
| FABP3 protein network | https://string-db.org/network/9606.ENSP00000362817 | Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters; Belongs to the calycin superfamily. Fatty-ac [...] |
| SRSF3 protein network | https://string-db.org/network/9606.ENSP00000362820 | Serine/arginine-rich splicing factor 3; Splicing factor that specifically promotes exon- inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and [...] |
| OGT protein network | https://string-db.org/network/9606.ENSP00000362824 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytopl [...] |
| KCTD20 protein network | https://string-db.org/network/9606.ENSP00000362836 | BTB/POZ domain-containing protein KCTD20; Promotes the phosphorylation of AKT family members |
| NKAIN1 protein network | https://string-db.org/network/9606.ENSP00000362841 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1; Sodium/potassium transporting ATPase interacting 1 |
| REEP3 protein network | https://string-db.org/network/9606.ENSP00000362863 | Receptor expression-enhancing protein 3; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from ch [...] |
| MORN5 protein network | https://string-db.org/network/9606.ENSP00000362869 | MORN repeat containing 5 |
| MATN1 protein network | https://string-db.org/network/9606.ENSP00000362870 | Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen; Matrilins |
| NDUFA8 protein network | https://string-db.org/network/9606.ENSP00000362873 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| ADO protein network | https://string-db.org/network/9606.ENSP00000362888 | 2-aminoethanethiol dioxygenase |
| RTKN2 protein network | https://string-db.org/network/9606.ENSP00000362894 | Rhotekin-2; May play an important role in lymphopoiesis; Pleckstrin homology domain containing |
| SRSF4 protein network | https://string-db.org/network/9606.ENSP00000362900 | Serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10; RNA binding motif containing |
| YTHDF2 protein network | https://string-db.org/network/9606.ENSP00000362918 | YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites o [...] |
| GSN protein network | https://string-db.org/network/9606.ENSP00000362924 | Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote [...] |
| SRPK1 protein network | https://string-db.org/network/9606.ENSP00000362931 | SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, know [...] |
| RAB42 protein network | https://string-db.org/network/9606.ENSP00000362932 | Ras-related protein Rab-42; RAB42, member RAS oncogene family |
| ITGB1BP2 protein network | https://string-db.org/network/9606.ENSP00000362935 | Integrin beta-1-binding protein 2; May play a role during maturation and/or organization of muscles cells |
| TRNAU1AP protein network | https://string-db.org/network/9606.ENSP00000362936 | tRNA selenocysteine 1-associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of [...] |
| RCC1 protein network | https://string-db.org/network/9606.ENSP00000362937 | Regulator of chromosome condensation; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the [...] |
| PHACTR4 protein network | https://string-db.org/network/9606.ENSP00000362942 | Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. [...] |
| RAB14 protein network | https://string-db.org/network/9606.ENSP00000362946 | Ras-related protein Rab-14; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containi [...] |
| MED18 protein network | https://string-db.org/network/9606.ENSP00000362948 | Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| CNTRL protein network | https://string-db.org/network/9606.ENSP00000362962 | Centriolin; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle- media [...] |
| PTAFR protein network | https://string-db.org/network/9606.ENSP00000362965 | Platelet-activating factor receptor; Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive ac [...] |
| CLPSL1 protein network | https://string-db.org/network/9606.ENSP00000362968 | Colipase-like protein 1; Colipase like 1; Belongs to the colipase family |
| EYA3 protein network | https://string-db.org/network/9606.ENSP00000362978 | Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair [...] |
| TGIF2 protein network | https://string-db.org/network/9606.ENSP00000362981 | Homeobox protein TGIF2; Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. [...] |
| PHYHIPL protein network | https://string-db.org/network/9606.ENSP00000362987 | Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system; Fibronectin type III domain containing |
| XKR8 protein network | https://string-db.org/network/9606.ENSP00000362991 | XK-related protein 8; Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the su [...] |
| BICC1 protein network | https://string-db.org/network/9606.ENSP00000362993 | Protein bicaudal C homolog 1; Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development; Sterile alph [...] |
| TRAF1 protein network | https://string-db.org/network/9606.ENSP00000362994 | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by [...] |
| SMPDL3B protein network | https://string-db.org/network/9606.ENSP00000363001 | Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition [...] |
| RPA2 protein network | https://string-db.org/network/9606.ENSP00000363017 | Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replicat [...] |
| RPL10A protein network | https://string-db.org/network/9606.ENSP00000363018 | 60S ribosomal protein L10a; Component of the large ribosomal subunit |
| UBE2D1 protein network | https://string-db.org/network/9606.ENSP00000363019 | Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates [...] |
| DLGAP4 protein network | https://string-db.org/network/9606.ENSP00000363023 | Disks large-associated protein 4; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...] |
| THEMIS2 protein network | https://string-db.org/network/9606.ENSP00000363031 | Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TNF production |
| MEGF9 protein network | https://string-db.org/network/9606.ENSP00000363040 | Multiple epidermal growth factor-like domains protein 9; Multiple EGF like domains 9 |
| CISD1 protein network | https://string-db.org/network/9606.ENSP00000363041 | CDGSH iron-sulfur domain-containing protein 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluste [...] |
| AAR2 protein network | https://string-db.org/network/9606.ENSP00000363043 | Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing |
| IPMK protein network | https://string-db.org/network/9606.ENSP00000363046 | Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakispho [...] |
| STX12 protein network | https://string-db.org/network/9606.ENSP00000363054 | Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (i [...] |
| ZWINT protein network | https://string-db.org/network/9606.ENSP00000363055 | ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase |
| ZNF76 protein network | https://string-db.org/network/9606.ENSP00000363064 | Zinc finger protein 76; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PCDH15 protein network | https://string-db.org/network/9606.ENSP00000363068 | Protocadherin-15; Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function; Cadherin related |
| DES protein network | https://string-db.org/network/9606.ENSP00000363071 | Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the [...] |
| MBL2 protein network | https://string-db.org/network/9606.ENSP00000363079 | Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complemen [...] |
| DKK1 protein network | https://string-db.org/network/9606.ENSP00000363081 | Dickkopf-related protein 1; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...] |
| TLR4 protein network | https://string-db.org/network/9606.ENSP00000363089 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, [...] |
| PRKG1 protein network | https://string-db.org/network/9606.ENSP00000363092 | cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serin [...] |
| SCAND1 protein network | https://string-db.org/network/9606.ENSP00000363103 | SCAN domain-containing protein 1; May regulate transcriptional activity; SCAN domain containing |
| FGR protein network | https://string-db.org/network/9606.ENSP00000363117 | Tyrosine-protein kinase Fgr; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune response [...] |
| ASAH2B protein network | https://string-db.org/network/9606.ENSP00000363118 | Putative inactive neutral ceramidase B; N-acylsphingosine amidohydrolase 2B |
| AHDC1 protein network | https://string-db.org/network/9606.ENSP00000363123 | AT-hook DNA-binding motif-containing protein 1; AT-hook DNA binding motif containing 1 |
| PHF20 protein network | https://string-db.org/network/9606.ENSP00000363124 | PHD finger protein 20; Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16 [...] |
| DEC1 protein network | https://string-db.org/network/9606.ENSP00000363128 | Deleted in esophageal cancer 1; Candidate tumor suppressor |
| GJB1 protein network | https://string-db.org/network/9606.ENSP00000363134 | Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| C6orf106 protein network | https://string-db.org/network/9606.ENSP00000363135 | Uncharacterized protein C6orf106; Chromosome 6 open reading frame 106 |
| GPR3 protein network | https://string-db.org/network/9606.ENSP00000363136 | G-protein coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavio [...] |
| CD164L2 protein network | https://string-db.org/network/9606.ENSP00000363139 | CD164 molecule like 2; Belongs to the CD164 family |
| SPDEF protein network | https://string-db.org/network/9606.ENSP00000363149 | SAM pointed domain-containing Ets transcription factor; May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. [...] |
| TNFSF15 protein network | https://string-db.org/network/9606.ENSP00000363157 | Tumor necrosis factor ligand superfamily member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promot [...] |
| ATP6V1G1 protein network | https://string-db.org/network/9606.ENSP00000363162 | V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in e [...] |
| ROMO1 protein network | https://string-db.org/network/9606.ENSP00000363191 | Reactive oxygen species modulator 1; Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicati [...] |
| MED12 protein network | https://string-db.org/network/9606.ENSP00000363193 | Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| NFS1 protein network | https://string-db.org/network/9606.ENSP00000363205 | Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved [...] |
| AGAP5 protein network | https://string-db.org/network/9606.ENSP00000363207 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5; Putative GTPase-activating protein; Ankyrin repeat domain containing |
| TIMM23B protein network | https://string-db.org/network/9606.ENSP00000363211 | Translocase of inner mitochondrial membrane 23 homolog B; TIM23 complex |
| OGDHL protein network | https://string-db.org/network/9606.ENSP00000363216 | 2-oxoglutarate dehydrogenase-like, mitochondrial; Oxoglutarate dehydrogenase like; Belongs to the alpha-ketoglutarate dehydrogenase family |
| C10orf53 protein network | https://string-db.org/network/9606.ENSP00000363226 | Chromosome 10 open reading frame 53 |
| RBM12 protein network | https://string-db.org/network/9606.ENSP00000363228 | RNA-binding protein 12; RNA binding motif containing |
| SLC18A3 protein network | https://string-db.org/network/9606.ENSP00000363229 | Vesicular acetylcholine transporter; Involved in acetylcholine transport into synaptic vesicles; Solute carriers |
| KIF12 protein network | https://string-db.org/network/9606.ENSP00000363232 | Kinesin-like protein KIF12; Kinesin family member 12; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family |
| PGBD3 protein network | https://string-db.org/network/9606.ENSP00000363242 | piggyBac transposable element derived 3; DNA transposon derived genes |
| GPN2 protein network | https://string-db.org/network/9606.ENSP00000363250 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; GPN-loop GTPases |
| DRGX protein network | https://string-db.org/network/9606.ENSP00000363254 | Dorsal root ganglia homeobox protein; Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perc [...] |
| RGS3 protein network | https://string-db.org/network/9606.ENSP00000363255 | Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-b [...] |
| ZDHHC18 protein network | https://string-db.org/network/9606.ENSP00000363257 | Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK; Zinc fingers DHHC-type |
| C10orf71 protein network | https://string-db.org/network/9606.ENSP00000363259 | Uncharacterized protein C10orf71; Chromosome 10 open reading frame 71 |
| PIGV protein network | https://string-db.org/network/9606.ENSP00000363260 | GPI mannosyltransferase 2; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI [...] |
| C10orf128 protein network | https://string-db.org/network/9606.ENSP00000363268 | Putative uncharacterized protein C10orf128; Chromosome 10 open reading frame 128 |
| RUFY4 protein network | https://string-db.org/network/9606.ENSP00000363270 | RUN and FYVE domain containing 4; Zinc fingers FYVE-type |
| POLE3 protein network | https://string-db.org/network/9606.ENSP00000363286 | DNA polymerase epsilon subunit 3; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling act [...] |
| BSPRY protein network | https://string-db.org/network/9606.ENSP00000363298 | B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity |
| WDR31 protein network | https://string-db.org/network/9606.ENSP00000363308 | WD repeat-containing protein 31; WD repeat domain containing |
| PRPF4 protein network | https://string-db.org/network/9606.ENSP00000363313 | U4/U6 small nuclear ribonucleoprotein Prp4; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome; U4/U6 small nucleolar ribonuc [...] |
| LIN28A protein network | https://string-db.org/network/9606.ENSP00000363314 | Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let- 7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seem [...] |
| FRMPD2 protein network | https://string-db.org/network/9606.ENSP00000363317 | FERM and PDZ domain-containing protein 2; May play a role in the regulation of tight junction formation. Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2); FERM domain containing |
| IL2RG protein network | https://string-db.org/network/9606.ENSP00000363318 | Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins; CD molecules |
| CDC26 protein network | https://string-db.org/network/9606.ENSP00000363322 | Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and t [...] |
| SLC31A1 protein network | https://string-db.org/network/9606.ENSP00000363329 | High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake; Solute carriers |
| CD52 protein network | https://string-db.org/network/9606.ENSP00000363330 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role; CD molecules |
| UBXN11 protein network | https://string-db.org/network/9606.ENSP00000363339 | UBX domain-containing protein 11; May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity) [...] |
| SLC46A2 protein network | https://string-db.org/network/9606.ENSP00000363345 | Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family |
| SNX30 protein network | https://string-db.org/network/9606.ENSP00000363349 | Sorting nexin-30; May be involved in several stages of intracellular trafficking; Autophagy related |
| INIP protein network | https://string-db.org/network/9606.ENSP00000363360 | SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates w [...] |
| CXorf65 protein network | https://string-db.org/network/9606.ENSP00000363369 | Uncharacterized protein CXorf65; Chromosome X open reading frame 65 |
| CNKSR1 protein network | https://string-db.org/network/9606.ENSP00000363371 | Connector enhancer of kinase suppressor of ras 1; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family |
| FOXO4 protein network | https://string-db.org/network/9606.ENSP00000363377 | Forkhead box protein O4; Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down [...] |
| SUSD1 protein network | https://string-db.org/network/9606.ENSP00000363382 | Sushi domain containing 1 |
| ZNF593 protein network | https://string-db.org/network/9606.ENSP00000363384 | Zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting [...] |
| FAM110D protein network | https://string-db.org/network/9606.ENSP00000363386 | Protein FAM110D; Family with sequence similarity 110 member D; Belongs to the FAM110 family |
| PDIK1L protein network | https://string-db.org/network/9606.ENSP00000363389 | Serine/threonine-protein kinase PDIK1L; PDLIM1 interacting kinase 1 like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| TRIM63 protein network | https://string-db.org/network/9606.ENSP00000363390 | E3 ubiquitin-protein ligase TRIM63; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of musc [...] |
| SPAG4 protein network | https://string-db.org/network/9606.ENSP00000363391 | Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anch [...] |
| SLC30A2 protein network | https://string-db.org/network/9606.ENSP00000363394 | Solute carrier family 30 member 2 |
| UGCG protein network | https://string-db.org/network/9606.ENSP00000363397 | Ceramide glucosyltransferase; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase"; Belongs to the glycosy [...] |
| EXTL1 protein network | https://string-db.org/network/9606.ENSP00000363398 | Exostosin-like 1; Probable glycosyltransferase; Belongs to the glycosyltransferase 47 family |
| PAFAH2 protein network | https://string-db.org/network/9606.ENSP00000363400 | Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the [...] |
| C9orf84 protein network | https://string-db.org/network/9606.ENSP00000363405 | Uncharacterized protein C9orf84; Chromosome 9 open reading frame 84 |
| GNG10 protein network | https://string-db.org/network/9606.ENSP00000363411 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...] |
| DNAJC25-GNG10 protein network | https://string-db.org/network/9606.ENSP00000363412 | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta a [...] |
| PAQR7 protein network | https://string-db.org/network/9606.ENSP00000363414 | Membrane progestin receptor alpha; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation. Involved i [...] |
| SLC7A3 protein network | https://string-db.org/network/9606.ENSP00000363417 | Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner; Belongs to the amino acid-polyamine-organocation [...] |
| MTFR1L protein network | https://string-db.org/network/9606.ENSP00000363419 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family |
| NPY4R protein network | https://string-db.org/network/9606.ENSP00000363431 | Neuropeptide Y receptor type 4; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro [...] |
| ITPR3 protein network | https://string-db.org/network/9606.ENSP00000363435 | Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium; Inositol 1,4,5-triphosphate recepto [...] |
| GPRIN2 protein network | https://string-db.org/network/9606.ENSP00000363436 | G protein-regulated inducer of neurite outgrowth 2; May be involved in neurite outgrowth |
| SYT15 protein network | https://string-db.org/network/9606.ENSP00000363441 | Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues; Synaptotagmins |
| MAN1C1 protein network | https://string-db.org/network/9606.ENSP00000363452 | Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)Gl [...] |
| LDLRAP1 protein network | https://string-db.org/network/9606.ENSP00000363458 | Low density lipoprotein receptor adapter protein 1; Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells [...] |
| PTPN20A protein network | https://string-db.org/network/9606.ENSP00000363459 | Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase act [...] |
| TMEM57 protein network | https://string-db.org/network/9606.ENSP00000363463 | Plays a role in the regulation of neuronal activity. |
| TMEM50A protein network | https://string-db.org/network/9606.ENSP00000363478 | Belongs to the UPF0220 family |
| DLG3 protein network | https://string-db.org/network/9606.ENSP00000363480 | Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling; Membrane associated guanylate kinases |
| FAM21C protein network | https://string-db.org/network/9606.ENSP00000363482 | WASH complex subunit 2C; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruit [...] |
| GDF5 protein network | https://string-db.org/network/9606.ENSP00000363492 | Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstl [...] |
| CLIC4 protein network | https://string-db.org/network/9606.ENSP00000363500 | Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane inse [...] |
| UQCC1 protein network | https://string-db.org/network/9606.ENSP00000363506 | Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...] |
| ALOX5 protein network | https://string-db.org/network/9606.ENSP00000363512 | Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes; Belongs to the lipoxygenase family |
| NCMAP protein network | https://string-db.org/network/9606.ENSP00000363513 | Noncompact myelin-associated protein; Plays a role in myelin formation |
| RCAN3 protein network | https://string-db.org/network/9606.ENSP00000363516 | Calcipressin-3; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (By simil [...] |
| NIPAL3 protein network | https://string-db.org/network/9606.ENSP00000363520 | NIPA-like protein 3; NIPA like domain containing 3 |
| KIF4A protein network | https://string-db.org/network/9606.ENSP00000363524 | Chromosome-associated kinesin KIF4A; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step f [...] |
| FAM83C protein network | https://string-db.org/network/9606.ENSP00000363529 | Protein FAM83C; May play a role in MAPK signaling |
| STPG1 protein network | https://string-db.org/network/9606.ENSP00000363530 | O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine |
| MDH1B protein network | https://string-db.org/network/9606.ENSP00000363533 | Malate dehydrogenase 1B |
| ZDBF2 protein network | https://string-db.org/network/9606.ENSP00000363545 | DBF4-type zinc finger-containing protein 2; Zinc finger DBF-type containing 2 |
| LPAR1 protein network | https://string-db.org/network/9606.ENSP00000363553 | Lysophosphatidic acid receptor 1; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and th [...] |
| MYOM3 protein network | https://string-db.org/network/9606.ENSP00000363557 | Myomesin-3; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle; Fibronectin type III domain containing |
| MUSK protein network | https://string-db.org/network/9606.ENSP00000363571 | Muscle, skeletal receptor tyrosine-protein kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse betwee [...] |
| EIF6 protein network | https://string-db.org/network/9606.ENSP00000363574 | Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Beh [...] |
| RASGEF1A protein network | https://string-db.org/network/9606.ENSP00000363583 | Ras-GEF domain-containing family member 1A; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration |
| CSGALNACT2 protein network | https://string-db.org/network/9606.ENSP00000363590 | Chondroitin sulfate N-acetylgalactosaminyltransferase 2; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of [...] |
| BAK1 protein network | https://string-db.org/network/9606.ENSP00000363591 | Bcl-2 homologous antagonist/killer; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovi [...] |
| CNR2 protein network | https://string-db.org/network/9606.ENSP00000363596 | Cannabinoid receptor 2; Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, noci [...] |
| FUCA1 protein network | https://string-db.org/network/9606.ENSP00000363603 | Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoprote [...] |
| HMGCL protein network | https://string-db.org/network/9606.ENSP00000363614 | Hydroxymethylglutaryl-CoA lyase, mitochondrial; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acet [...] |
| EDEM2 protein network | https://string-db.org/network/9606.ENSP00000363616 | ER degradation-enhancing alpha-mannosidase-like protein 2; Initiates the endoplasmic reticulum-associated degradation (ERAD) that targets misfolded glycoproteins for degradation in an N-glycan-de [...] |
| CUTA protein network | https://string-db.org/network/9606.ENSP00000363624 | Protein CutA; May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE); Belongs to the CutA family |
| TXNDC8 protein network | https://string-db.org/network/9606.ENSP00000363634 | Thioredoxin domain-containing protein 8; May be required for post-translational modifications of proteins required for acrosomal biogenesis. May act by reducing disulfide bonds within the sperm |
| LYPLA2 protein network | https://string-db.org/network/9606.ENSP00000363638 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoyla [...] |
| PHF1 protein network | https://string-db.org/network/9606.ENSP00000363640 | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited [...] |
| TXN protein network | https://string-db.org/network/9606.ENSP00000363641 | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role [...] |
| BMS1 protein network | https://string-db.org/network/9606.ENSP00000363642 | Ribosome biogenesis protein BMS1 homolog; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus |
| P2RY4 protein network | https://string-db.org/network/9606.ENSP00000363643 | P2Y purinoceptor 4; Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP |
| AWAT1 protein network | https://string-db.org/network/9606.ENSP00000363645 | Acyl-CoA wax alcohol acyltransferase 1; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in s [...] |
| PALM2AKAP2 protein network | https://string-db.org/network/9606.ENSP00000363654 | Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, ampli [...] |
| IGBP1 protein network | https://string-db.org/network/9606.ENSP00000363661 | Immunoglobulin-binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP [...] |
| PTPN3 protein network | https://string-db.org/network/9606.ENSP00000363667 | Tyrosine-protein phosphatase non-receptor type 3; May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity; FERM domain containing |
| DAXX protein network | https://string-db.org/network/9606.ENSP00000363668 | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcripti [...] |
| RPL11 protein network | https://string-db.org/network/9606.ENSP00000363676 | 60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RN [...] |
| EDA protein network | https://string-db.org/network/9606.ENSP00000363680 | Ectodysplasin-A; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors E [...] |
| MDS2 protein network | https://string-db.org/network/9606.ENSP00000363683 | Myelodysplastic syndrome 2 translocation associated |
| ID3 protein network | https://string-db.org/network/9606.ENSP00000363689 | DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...] |
| EPB41L4B protein network | https://string-db.org/network/9606.ENSP00000363694 | Band 4.1-like protein 4B; Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in ep [...] |
| BMPR2 protein network | https://string-db.org/network/9606.ENSP00000363708 | Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphor [...] |
| TMEM245 protein network | https://string-db.org/network/9606.ENSP00000363714 | Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family |
| STARD8 protein network | https://string-db.org/network/9606.ENSP00000363727 | StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5- bisphosphate by PLCD1 |
| HNRNPR protein network | https://string-db.org/network/9606.ENSP00000363745 | Heterogeneous nuclear ribonucleoprotein R; Component of ribonucleosomes, which are complexes of at least 20 other different heterogenious nuclear ribonucleoproteins (hnRNP). hnRNP play an importa [...] |
| WDR46 protein network | https://string-db.org/network/9606.ENSP00000363746 | WD repeat-containing protein 46; Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus; WD repeat domain containin [...] |
| HTR1D protein network | https://string-db.org/network/9606.ENSP00000363748 | 5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant [...] |
| FAM206A protein network | https://string-db.org/network/9606.ENSP00000363753 | Protein Simiate; Family with sequence similarity 206 member A |
| EPHB2 protein network | https://string-db.org/network/9606.ENSP00000363763 | Ephrin type-B receptor 2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| C1QC protein network | https://string-db.org/network/9606.ENSP00000363770 | Complement C1q subcomponent subunit C; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...] |
| C1QA protein network | https://string-db.org/network/9606.ENSP00000363773 | Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact wi [...] |
| IKBKAP protein network | https://string-db.org/network/9606.ENSP00000363779 | Elongator complex protein 1; May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK); Belongs to the ELP1/IKA1 family |
| RING1 protein network | https://string-db.org/network/9606.ENSP00000363787 | E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code [...] |
| HSD17B8 protein network | https://string-db.org/network/9606.ENSP00000363794 | Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with [...] |
| ACTL7B protein network | https://string-db.org/network/9606.ENSP00000363799 | Actin-like protein 7B; Actin related proteins; Belongs to the actin family |
| KLF4 protein network | https://string-db.org/network/9606.ENSP00000363804 | Krueppel-like factor 4; Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its ow [...] |
| SLC39A7 protein network | https://string-db.org/network/9606.ENSP00000363809 | Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Transport is stimulated by growth factors, such as EGF, and Ca(2+ [...] |
| RXRB protein network | https://string-db.org/network/9606.ENSP00000363817 | Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retino [...] |
| AR protein network | https://string-db.org/network/9606.ENSP00000363822 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target ti [...] |
| TMEM38B protein network | https://string-db.org/network/9606.ENSP00000363824 | Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions [...] |
| FZD8 protein network | https://string-db.org/network/9606.ENSP00000363826 | Frizzled-8; Receptor for Wnt proteins. Component of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome- si [...] |
| HSPG2 protein network | https://string-db.org/network/9606.ENSP00000363827 | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed nega [...] |
| AOX1 protein network | https://string-db.org/network/9606.ENSP00000363832 | Aldehyde oxidase; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N- methylphthalazinium and phthalazine, as well as aldehydes, such a [...] |
| CCNY protein network | https://string-db.org/network/9606.ENSP00000363836 | Cyclin-Y; Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to [...] |
| COL11A2 protein network | https://string-db.org/network/9606.ENSP00000363840 | Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Collagens |
| SLC44A1 protein network | https://string-db.org/network/9606.ENSP00000363852 | Choline transporter-like protein 1; Choline transporter. May be involved in membrane synthesis and myelin production; Belongs to the CTL (choline transporter-like) family |
| ABCA1 protein network | https://string-db.org/network/9606.ENSP00000363868 | ATP-binding cassette sub-family A member 1; cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport; Belongs to the ABC transpo [...] |
| VSIG4 protein network | https://string-db.org/network/9606.ENSP00000363869 | V-set and immunoglobulin domain-containing protein 4; Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pat [...] |
| OXLD1 protein network | https://string-db.org/network/9606.ENSP00000363873 | Oxidoreductase-like domain-containing protein 1; Oxidoreductase like domain containing 1 |
| SLC38A10 protein network | https://string-db.org/network/9606.ENSP00000363891 | Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter; Solute carriers |
| NIPSNAP3B protein network | https://string-db.org/network/9606.ENSP00000363894 | Nipsnap homolog 3B; Belongs to the NipSnap family |
| NIPSNAP3A protein network | https://string-db.org/network/9606.ENSP00000363899 | Nipsnap homolog 3A; Belongs to the NipSnap family |
| OR13C5 protein network | https://string-db.org/network/9606.ENSP00000363911 | Olfactory receptor 13C5; Odorant receptor; Olfactory receptors, family 13 |
| OR13C3 protein network | https://string-db.org/network/9606.ENSP00000363913 | Olfactory receptor 13C3; Odorant receptor; Olfactory receptors, family 13 |
| PARD3 protein network | https://string-db.org/network/9606.ENSP00000363921 | Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctio [...] |
| NCOA6 protein network | https://string-db.org/network/9606.ENSP00000363929 | Nuclear receptor coactivator 6; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expres [...] |
| PPP3R2 protein network | https://string-db.org/network/9606.ENSP00000363939 | Calcineurin subunit B type 2; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity); EF-hand domain contai [...] |
| TP53INP2 protein network | https://string-db.org/network/9606.ENSP00000363943 | Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as [...] |
| LAS1L protein network | https://string-db.org/network/9606.ENSP00000363944 | Ribosomal biogenesis protein LAS1L; Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CH [...] |
| MAP1LC3A protein network | https://string-db.org/network/9606.ENSP00000363970 | Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the pha [...] |
| ZC4H2 protein network | https://string-db.org/network/9606.ENSP00000363972 | Zinc finger C4H2 domain-containing protein; Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation; Zinc fingers |
| ALPL protein network | https://string-db.org/network/9606.ENSP00000363973 | Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme may play a role in skeletal mineralization; Belongs to the alkaline phosphatase family |
| HLA-DMA protein network | https://string-db.org/network/9606.ENSP00000363976 | HLA class II histocompatibility antigen, DM alpha chain; Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II [...] |
| TMEM246 protein network | https://string-db.org/network/9606.ENSP00000363984 | Transmembrane protein 246 |
| MTMR8 protein network | https://string-db.org/network/9606.ENSP00000363985 | Myotubularin-related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup; Myotubularins |
| ALDOB protein network | https://string-db.org/network/9606.ENSP00000363988 | Belongs to the class I fructose-bisphosphate aldolase family |
| PSMB9 protein network | https://string-db.org/network/9606.ENSP00000363993 | Proteasome subunit beta type-9; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the lea [...] |
| MRPL50 protein network | https://string-db.org/network/9606.ENSP00000363999 | Mitochondrial ribosomal protein L50 |
| COL5A2 protein network | https://string-db.org/network/9606.ENSP00000364000 | Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collag [...] |
| PLPPR1 protein network | https://string-db.org/network/9606.ENSP00000364008 | Lipid phosphate phosphatase-related protein type 1 |
| TMEFF1 protein network | https://string-db.org/network/9606.ENSP00000364013 | Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers |
| PSMB8 protein network | https://string-db.org/network/9606.ENSP00000364016 | Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the lea [...] |
| ZXDB protein network | https://string-db.org/network/9606.ENSP00000364023 | Zinc finger X-linked protein ZXDB; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Belongs to the ZXD family |
| ECE1 protein network | https://string-db.org/network/9606.ENSP00000364028 | Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1; Belongs to the peptidase M13 family |
| TAP2 protein network | https://string-db.org/network/9606.ENSP00000364034 | Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold [...] |
| FAAH2 protein network | https://string-db.org/network/9606.ENSP00000364035 | Fatty-acid amide hydrolase 2; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to termin [...] |
| TEX10 protein network | https://string-db.org/network/9606.ENSP00000364037 | Testis-expressed protein 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation [...] |
| SPIN2A protein network | https://string-db.org/network/9606.ENSP00000364043 | Spindlin-2A; May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity; Spindlin family |
| SPIN3 protein network | https://string-db.org/network/9606.ENSP00000364054 | Spindlin-3; Exhibits H3K4me3-binding activity; Spindlin family |
| HLA-DQA2 protein network | https://string-db.org/network/9606.ENSP00000364076 | HLA class II histocompatibility antigen, DQ alpha 2 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell sur [...] |
| HLA-DQB1 protein network | https://string-db.org/network/9606.ENSP00000364080 | HLA class II histocompatibility antigen, DQ beta 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...] |
| PAGE3 protein network | https://string-db.org/network/9606.ENSP00000364089 | PAGE family member 3 |
| PAGE2 protein network | https://string-db.org/network/9606.ENSP00000364107 | PAGE family member 2 |
| PAGE2B protein network | https://string-db.org/network/9606.ENSP00000364110 | PAGE family member 2B; Belongs to the GAGE family |
| HLA-DRB5 protein network | https://string-db.org/network/9606.ENSP00000364114 | HLA class II histocompatibility antigen, DR beta 5 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...] |
| EIF2S2 protein network | https://string-db.org/network/9606.ENSP00000364119 | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S [...] |
| APEX2 protein network | https://string-db.org/network/9606.ENSP00000364126 | DNA-(apurinic or apyrimidinic site) lyase 2; Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative [...] |
| TGFBR1 protein network | https://string-db.org/network/9606.ENSP00000364133 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines [...] |
| COL15A1 protein network | https://string-db.org/network/9606.ENSP00000364140 | Collagen alpha-1(XV) chain; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle; Collagen proteoglycans |
| PFKFB1 protein network | https://string-db.org/network/9606.ENSP00000364145 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family |
| GALNT12 protein network | https://string-db.org/network/9606.ENSP00000364150 | Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| OR8B2 protein network | https://string-db.org/network/9606.ENSP00000364152 | Olfactory receptor 8B2; Odorant receptor; Olfactory receptors, family 8 |
| NOTCH4 protein network | https://string-db.org/network/9606.ENSP00000364163 | Neurogenic locus notch homolog protein 4; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the re [...] |
| OR10G9 protein network | https://string-db.org/network/9606.ENSP00000364164 | Olfactory receptor 10G9; Odorant receptor; Olfactory receptors, family 10 |
| ENSG00000150076 protein network | https://string-db.org/network/9606.ENSP00000364165 | Coiled-coil domain containing 7; May play a role in tumorigenesis |
| TMEM225 protein network | https://string-db.org/network/9606.ENSP00000364166 | Transmembrane protein 225; Probably inhibits protein phosphatase 1 (PP1) in sperm via binding to catalytic subunit PPP1CC |
| GPSM3 protein network | https://string-db.org/network/9606.ENSP00000364180 | G-protein-signaling modulator 3; Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins |
| PBX2 protein network | https://string-db.org/network/9606.ENSP00000364190 | Pre-B-cell leukemia transcription factor 2; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1; TALE class homeoboxes and pse [...] |
| PINK1 protein network | https://string-db.org/network/9606.ENSP00000364204 | Serine/threonine-protein kinase PINK1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of dam [...] |
| MAGED2 protein network | https://string-db.org/network/9606.ENSP00000364209 | Melanoma-associated antigen D2; Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt re [...] |
| AGER protein network | https://string-db.org/network/9606.ENSP00000364210 | Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vasc [...] |
| CDA protein network | https://string-db.org/network/9606.ENSP00000364212 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis |
| CAMK2N1 protein network | https://string-db.org/network/9606.ENSP00000364219 | Calcium/calmodulin-dependent protein kinase II inhibitor 1; Potent and specific inhibitor of CaM-kinase II (CAMK2); Belongs to the CAMK2N family |
| VWA5B1 protein network | https://string-db.org/network/9606.ENSP00000364220 | Von Willebrand factor A domain containing 5B1 |
| RNF5 protein network | https://string-db.org/network/9606.ENSP00000364235 | E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiqui [...] |
| UBXN10 protein network | https://string-db.org/network/9606.ENSP00000364240 | UBX domain-containing protein 10; VCP/p97-binding protein required for ciliogenesis. Acts as a tethering factor that facilitates recruitment of VCP/p97 to the intraflagellar transport complex B ( [...] |
| PLA2G2F protein network | https://string-db.org/network/9606.ENSP00000364243 | Group IIF secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine wi [...] |
| PLA2G2D protein network | https://string-db.org/network/9606.ENSP00000364246 | Group IID secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is [...] |
| PLA2G5 protein network | https://string-db.org/network/9606.ENSP00000364249 | Calcium-dependent phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2- [...] |
| PLA2G2E protein network | https://string-db.org/network/9606.ENSP00000364257 | Group IIE secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids; Ph [...] |
| C9orf156 protein network | https://string-db.org/network/9606.ENSP00000364260 | tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoylade [...] |
| OTUD3 protein network | https://string-db.org/network/9606.ENSP00000364261 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains; OTU dom [...] |
| RNF186 protein network | https://string-db.org/network/9606.ENSP00000364263 | E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress . In that process, stimulates the expression of proteins specific of the unfol [...] |
| FOXE1 protein network | https://string-db.org/network/9606.ENSP00000364265 | Forkhead box protein E1; Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably throug [...] |
| XPA protein network | https://string-db.org/network/9606.ENSP00000364270 | DNA repair protein complementing XP-A cells; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcrip [...] |
| FGD1 protein network | https://string-db.org/network/9606.ENSP00000364277 | FYVE, RhoGEF and PH domain-containing protein 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the ac [...] |
| NCBP1 protein network | https://string-db.org/network/9606.ENSP00000364289 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA [...] |
| TSR2 protein network | https://string-db.org/network/9606.ENSP00000364293 | Pre-rRNA-processing protein TSR2 homolog; May be involved in 20S pre-rRNA processing |
| PQLC2 protein network | https://string-db.org/network/9606.ENSP00000364295 | Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes |
| FKBPL protein network | https://string-db.org/network/9606.ENSP00000364298 | FK506-binding protein-like; May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21; FKBP prolyl isomerases |
| MRTO4 protein network | https://string-db.org/network/9606.ENSP00000364320 | mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolu [...] |
| FAM120C protein network | https://string-db.org/network/9606.ENSP00000364324 | Constitutive coactivator of PPAR-gamma-like protein 2; Family with sequence similarity 120C; Belongs to the constitutive coactivator of PPAR-gamma family |
| ZNF341 protein network | https://string-db.org/network/9606.ENSP00000364346 | Zinc finger protein 341; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ATF6B protein network | https://string-db.org/network/9606.ENSP00000364349 | Cyclic AMP-dependent transcription factor ATF-6 beta; Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Bind [...] |
| ZAK protein network | https://string-db.org/network/9606.ENSP00000364361 | Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that [...] |
| C20orf144 protein network | https://string-db.org/network/9606.ENSP00000364370 | Uncharacterized protein C20orf144; Chromosome 20 open reading frame 144 |
| ZNF510 protein network | https://string-db.org/network/9606.ENSP00000364379 | Zinc finger protein 510; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| AAED1 protein network | https://string-db.org/network/9606.ENSP00000364382 | Thioredoxin-like protein AAED1; AhpC/TSA antioxidant enzyme domain containing 1; Belongs to the AAED1 family |
| CDC14B protein network | https://string-db.org/network/9606.ENSP00000364389 | Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates [...] |
| HABP4 protein network | https://string-db.org/network/9606.ENSP00000364398 | Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding acti [...] |
| UBR4 protein network | https://string-db.org/network/9606.ENSP00000364403 | E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destab [...] |
| DCAF17 protein network | https://string-db.org/network/9606.ENSP00000364404 | DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| ZNF367 protein network | https://string-db.org/network/9606.ENSP00000364405 | Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes; Zinc fingers C2H2-type |
| HSD17B3 protein network | https://string-db.org/network/9606.ENSP00000364412 | Testosterone 17-beta-dehydrogenase 3; Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH; Short chain dehydrogenase/reductase superfam [...] |
| SP5 protein network | https://string-db.org/network/9606.ENSP00000364430 | Transcription factor Sp5; Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in [...] |
| UPF3A protein network | https://string-db.org/network/9606.ENSP00000364448 | Regulator of nonsense transcripts 3A; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving a [...] |
| SIK3 protein network | https://string-db.org/network/9606.ENSP00000364449 | Serine/threonine-protein kinase SIK3; SIK family kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily |
| C9orf3 protein network | https://string-db.org/network/9606.ENSP00000364464 | Aminopeptidase O; Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a [...] |
| LYZL2 protein network | https://string-db.org/network/9606.ENSP00000364467 | Lysozyme-like protein 2; Lysozymes, c-type |
| RIBC1 protein network | https://string-db.org/network/9606.ENSP00000364476 | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family |
| STK19 protein network | https://string-db.org/network/9606.ENSP00000364482 | Serine/threonine-protein kinase 19; Seems to be a protein kinase. In vitro it can phosphorylate casein-alpha on serine and threonine residues and histones on serine residues |
| FBP2 protein network | https://string-db.org/network/9606.ENSP00000364486 | Fructose-1,6-bisphosphatase isozyme 2; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synt [...] |
| ALDH4A1 protein network | https://string-db.org/network/9606.ENSP00000364490 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5- carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a [...] |
| HIATL1 protein network | https://string-db.org/network/9606.ENSP00000364493 | Hippocampus abundant transcript-like 1; Belongs to the major facilitator superfamily |
| DXO protein network | https://string-db.org/network/9606.ENSP00000364498 | Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphoh [...] |
| CD300LD protein network | https://string-db.org/network/9606.ENSP00000364501 | CMRF35-like molecule 4; CD300 molecule like family member d; V-set domain containing |
| TMEM255B protein network | https://string-db.org/network/9606.ENSP00000364502 | Transmembrane protein 255B |
| G6PC2 protein network | https://string-db.org/network/9606.ENSP00000364512 | Glucose-6-phosphatase 2; May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By simila [...] |
| BTBD17 protein network | https://string-db.org/network/9606.ENSP00000364515 | BTB/POZ domain-containing protein 17; BTB domain containing 17 |
| TFDP1 protein network | https://string-db.org/network/9606.ENSP00000364519 | Transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter reg [...] |
| TAS1R2 protein network | https://string-db.org/network/9606.ENSP00000364520 | Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners |
| PAX7 protein network | https://string-db.org/network/9606.ENSP00000364524 | Paired box protein Pax-7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation; PRD class homeoboxes and pseudogenes |
| KIAA1462 protein network | https://string-db.org/network/9606.ENSP00000364526 | Junctional protein associated with coronary artery disease; KIAA1462 |
| SKIV2L protein network | https://string-db.org/network/9606.ENSP00000364543 | Helicase SKI2W; Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a m [...] |
| KDM5C protein network | https://string-db.org/network/9606.ENSP00000364550 | Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', [...] |
| ACTL8 protein network | https://string-db.org/network/9606.ENSP00000364555 | Actin-like protein 8; Actin related proteins |
| FAM120AOS protein network | https://string-db.org/network/9606.ENSP00000364561 | Uncharacterized protein FAM120AOS; Family with sequence similarity 120A opposite strand |
| ADPRHL1 protein network | https://string-db.org/network/9606.ENSP00000364567 | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1 |
| C9orf129 protein network | https://string-db.org/network/9606.ENSP00000364568 | Putative uncharacterized protein C9orf129; Chromosome 9 open reading frame 129 |
| NELFE protein network | https://string-db.org/network/9606.ENSP00000364578 | Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...] |
| GRTP1 protein network | https://string-db.org/network/9606.ENSP00000364579 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s) |
| RCC2 protein network | https://string-db.org/network/9606.ENSP00000364585 | Protein RCC2; Required for completion of mitosis and cytokinesis. May function as a guanine nucleotide exchange factor for the small GTPase RAC1 |
| SCN2A protein network | https://string-db.org/network/9606.ENSP00000364586 | Sodium channel protein type 2 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| CUL4A protein network | https://string-db.org/network/9606.ENSP00000364589 | Cullin-4A; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysi [...] |
| TSPYL2 protein network | https://string-db.org/network/9606.ENSP00000364591 | Testis-specific Y-encoded-like protein 2; Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating [...] |
| NINJ1 protein network | https://string-db.org/network/9606.ENSP00000364595 | Ninjurin-1; Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalen [...] |
| PADI4 protein network | https://string-db.org/network/9606.ENSP00000364597 | Protein-arginine deiminase type-4; Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem ce [...] |
| BPIFA3 protein network | https://string-db.org/network/9606.ENSP00000364603 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family |
| PADI3 protein network | https://string-db.org/network/9606.ENSP00000364609 | Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases |
| C9orf89 protein network | https://string-db.org/network/9606.ENSP00000364613 | Chromosome 9 open reading frame 89 |
| PADI1 protein network | https://string-db.org/network/9606.ENSP00000364620 | Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases |
| SUSD3 protein network | https://string-db.org/network/9606.ENSP00000364621 | Sushi domain-containing protein 3; May play a role in breast tumorigenesis by promoting estrogen-dependent cell proliferation, cell-cell interactions and migration; Sushi domain containing |
| NXPE4 protein network | https://string-db.org/network/9606.ENSP00000364627 | NXPE family member 4; Neurexophilin and PC-esterase domain family member 4; Belongs to the NXPE family |
| FGD3 protein network | https://string-db.org/network/9606.ENSP00000364631 | FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for fre [...] |
| BPIFB4 protein network | https://string-db.org/network/9606.ENSP00000364632 | BPI fold-containing family B member 4; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to acc [...] |
| PADI2 protein network | https://string-db.org/network/9606.ENSP00000364635 | Protein-arginine deiminase type-2; Catalyzes the deimination of arginine residues of proteins; Peptidyl arginine deiminases |
| RBM7 protein network | https://string-db.org/network/9606.ENSP00000364639 | RNA-binding protein 7; Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. The RNA exosome i [...] |
| BPIFB3 protein network | https://string-db.org/network/9606.ENSP00000364643 | BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to acc [...] |
| SDHB protein network | https://string-db.org/network/9606.ENSP00000364649 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial elec [...] |
| LYZL1 protein network | https://string-db.org/network/9606.ENSP00000364650 | Lysozyme-like protein 1; Lysozymes, c-type; Belongs to the glycosyl hydrolase 22 family |
| SPANXN5 protein network | https://string-db.org/network/9606.ENSP00000364661 | Sperm protein associated with the nucleus on the X chromosome N5; SPANX family member N5; Belongs to the SPAN-X family |
| ZBTB12 protein network | https://string-db.org/network/9606.ENSP00000364677 | Zinc finger and BTB domain-containing protein 12; May be involved in transcriptional regulation; BTB domain containing |
| EHMT2 protein network | https://string-db.org/network/9606.ENSP00000364678 | Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me repre [...] |
| BAMBI protein network | https://string-db.org/network/9606.ENSP00000364683 | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling; Belongs to the BAMBI family |
| MFAP2 protein network | https://string-db.org/network/9606.ENSP00000364685 | Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils; Belongs to the MFAP family |
| CROCC protein network | https://string-db.org/network/9606.ENSP00000364691 | Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends prox [...] |
| ASPN protein network | https://string-db.org/network/9606.ENSP00000364694 | Asporin; Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhi [...] |
| SDHD protein network | https://string-db.org/network/9606.ENSP00000364699 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial ele [...] |
| OMD protein network | https://string-db.org/network/9606.ENSP00000364700 | Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)- integrin (By similarity); Small leucine rich repeat proteoglycans |
| F10 protein network | https://string-db.org/network/9606.ENSP00000364709 | Coagulation factor X; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Gla domai [...] |
| MAPRE1 protein network | https://string-db.org/network/9606.ENSP00000364721 | Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus- end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Prom [...] |
| F7 protein network | https://string-db.org/network/9606.ENSP00000364731 | Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, [...] |
| CENPP protein network | https://string-db.org/network/9606.ENSP00000364737 | Centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...] |
| FBXO42 protein network | https://string-db.org/network/9606.ENSP00000364742 | F-box only protein 42; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and [...] |
| RSG1 protein network | https://string-db.org/network/9606.ENSP00000364749 | REM2- and Rab-like small GTPase 1; Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion wit [...] |
| XAGE1A protein network | https://string-db.org/network/9606.ENSP00000364752 | X antigen family member 1A |
| LAYN protein network | https://string-db.org/network/9606.ENSP00000364765 | Layilin; Receptor for hyaluronate; C-type lectin domain containing |
| XAGE1B protein network | https://string-db.org/network/9606.ENSP00000364766 | X antigen family member 1B; Belongs to the GAGE family |
| NEU1 protein network | https://string-db.org/network/9606.ENSP00000364782 | Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme c [...] |
| C6orf48 protein network | https://string-db.org/network/9606.ENSP00000364791 | Protein G8; Chromosome 6 open reading frame 48 |
| IARS protein network | https://string-db.org/network/9606.ENSP00000364794 | Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...] |
| HSPA1B protein network | https://string-db.org/network/9606.ENSP00000364801 | Heat shock protein family A member 1B |
| HSPA1A protein network | https://string-db.org/network/9606.ENSP00000364802 | Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized [...] |
| HSPA1L protein network | https://string-db.org/network/9606.ENSP00000364805 | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesi [...] |
| LSM2 protein network | https://string-db.org/network/9606.ENSP00000364813 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing; Belongs to the snRNP Sm proteins family |
| FAM131C protein network | https://string-db.org/network/9606.ENSP00000364814 | Protein FAM131C; Family with sequence similarity 131 member C |
| VARS protein network | https://string-db.org/network/9606.ENSP00000364815 | Valine--tRNA ligase; Aminoacyl tRNA synthetases, Class I |
| CLCNKB protein network | https://string-db.org/network/9606.ENSP00000364831 | Chloride channel protein ClC-Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transdu [...] |
| ASXL1 protein network | https://string-db.org/network/9606.ENSP00000364839 | Putative Polycomb group protein ASXL1; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid recep [...] |
| VWA7 protein network | https://string-db.org/network/9606.ENSP00000364840 | Von Willebrand factor A domain containing 7 |
| MAGED1 protein network | https://string-db.org/network/9606.ENSP00000364847 | Melanoma-associated antigen D1; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apopto [...] |
| MSH5 protein network | https://string-db.org/network/9606.ENSP00000364855 | MutS protein homolog 5; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity); Belongs to the DNA mismatch re [...] |
| CARD16 protein network | https://string-db.org/network/9606.ENSP00000364858 | Caspase recruitment domain-containing protein 16; Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interl [...] |
| CARD17 protein network | https://string-db.org/network/9606.ENSP00000364859 | Caspase recruitment domain-containing protein 17; Regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-IL-1beta/IL1B and its release during [...] |
| ROR2 protein network | https://string-db.org/network/9606.ENSP00000364860 | Tyrosine-protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and g [...] |
| KIF3B protein network | https://string-db.org/network/9606.ENSP00000364864 | Kinesin-like protein KIF3B; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-di [...] |
| AUH protein network | https://string-db.org/network/9606.ENSP00000364883 | Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA. Also has itaconyl-CoA hydratase activity by converting itacon [...] |
| ZBTB17 protein network | https://string-db.org/network/9606.ENSP00000364885 | Zinc finger and BTB domain-containing protein 17; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of ce [...] |
| RND3 protein network | https://string-db.org/network/9606.ENSP00000364886 | Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins; Rho family GTPases |
| ARHGEF7 protein network | https://string-db.org/network/9606.ENSP00000364893 | Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Pro [...] |
| POFUT1 protein network | https://string-db.org/network/9606.ENSP00000364902 | GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C [...] |
| SYK protein network | https://string-db.org/network/9606.ENSP00000364907 | Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell [...] |
| SPEN protein network | https://string-db.org/network/9606.ENSP00000364912 | Msx2-interacting protein; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 [...] |
| DIRAS2 protein network | https://string-db.org/network/9606.ENSP00000364919 | GTP-binding protein Di-Ras2; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family |
| ING1 protein network | https://string-db.org/network/9606.ENSP00000364929 | Inhibitor of growth protein 1; Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor [...] |
| CLIC1 protein network | https://string-db.org/network/9606.ENSP00000364935 | Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occu [...] |
| TMEM82 protein network | https://string-db.org/network/9606.ENSP00000364938 | Transmembrane protein 82 |
| DDAH2 protein network | https://string-db.org/network/9606.ENSP00000364945 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in t [...] |
| MKX protein network | https://string-db.org/network/9606.ENSP00000364946 | Homeobox protein Mohawk; May act as a morphogenetic regulator of cell adhesion; TALE class homeoboxes and pseudogenes |
| PLEKHM2 protein network | https://string-db.org/network/9606.ENSP00000364956 | Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play [...] |
| C6orf25 protein network | https://string-db.org/network/9606.ENSP00000364964 | Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:12665801, PubMed:17311996, PubMed:27743390). [...] |
| SECISBP2 protein network | https://string-db.org/network/9606.ENSP00000364965 | Selenocysteine insertion sequence-binding protein 2; Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB |
| CKS2 protein network | https://string-db.org/network/9606.ENSP00000364976 | Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function |
| LY6G6C protein network | https://string-db.org/network/9606.ENSP00000364978 | Lymphocyte antigen 6 family member G6C; LY6/PLAUR domain containing |
| COL4A1 protein network | https://string-db.org/network/9606.ENSP00000364979 | Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| LY6G6D protein network | https://string-db.org/network/9606.ENSP00000364985 | Lymphocyte antigen 6 family member G6D; LY6/PLAUR domain containing |
| AGMAT protein network | https://string-db.org/network/9606.ENSP00000364986 | Agmatinase, mitochondrial; Agmatinase |
| LY6G6F protein network | https://string-db.org/network/9606.ENSP00000364992 | Lymphocyte antigen 6 complex locus protein G6f; May play a role in the downstream signal transduction pathways involving GRB2 and GRB7; LY6/PLAUR domain containing |
| SHC3 protein network | https://string-db.org/network/9606.ENSP00000364995 | SHC-transforming protein 3; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activate [...] |
| MAP3K19 protein network | https://string-db.org/network/9606.ENSP00000365005 | Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily |
| S1PR3 protein network | https://string-db.org/network/9606.ENSP00000365006 | Sphingosine 1-phosphate receptor 3; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types o [...] |
| DNAJC16 protein network | https://string-db.org/network/9606.ENSP00000365007 | DnaJ heat shock protein family member C16 |
| NXNL2 protein network | https://string-db.org/network/9606.ENSP00000365014 | Nucleoredoxin-like protein 2; May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons; Nucleoredoxin family |
| IRS2 protein network | https://string-db.org/network/9606.ENSP00000365016 | Insulin receptor substrate 2; May mediate the control of various cellular processes by insulin; Pleckstrin homology domain containing |
| SPIN1 protein network | https://string-db.org/network/9606.ENSP00000365019 | Spindlin-1; Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activ [...] |
| LY6G5B protein network | https://string-db.org/network/9606.ENSP00000365024 | Lymphocyte antigen 6 family member G5B; LY6/PLAUR domain containing |
| CSNK2B protein network | https://string-db.org/network/9606.ENSP00000365042 | Casein kinase II subunit beta; Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 [...] |
| TNFSF13B protein network | https://string-db.org/network/9606.ENSP00000365048 | Tumor necrosis factor ligand superfamily member 13B; Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 recep [...] |
| ABHD13 protein network | https://string-db.org/network/9606.ENSP00000365063 | Protein ABHD13; Abhydrolase domain containing 13 |
| GPANK1 protein network | https://string-db.org/network/9606.ENSP00000365071 | G-patch domain and ankyrin repeats 1 |
| CELA2B protein network | https://string-db.org/network/9606.ENSP00000365075 | Chymotrypsin-like elastase family member 2B; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily |
| C6orf47 protein network | https://string-db.org/network/9606.ENSP00000365076 | Uncharacterized protein C6orf47; Chromosome 6 open reading frame 47 |
| FAM155A protein network | https://string-db.org/network/9606.ENSP00000365080 | Transmembrane protein FAM155A; Family with sequence similarity 155 member A |
| APOM protein network | https://string-db.org/network/9606.ENSP00000365081 | Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid; [...] |
| MASTL protein network | https://string-db.org/network/9606.ENSP00000365107 | Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation o [...] |
| CTRC protein network | https://string-db.org/network/9606.ENSP00000365116 | Chymotrypsin-C; Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease [...] |
| ZCCHC6 protein network | https://string-db.org/network/9606.ENSP00000365130 | Terminal uridylyltransferase 7; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Invo [...] |
| BAG6 protein network | https://string-db.org/network/9606.ENSP00000365131 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein [...] |
| FOXS1 protein network | https://string-db.org/network/9606.ENSP00000365145 | Forkhead box protein S1; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By s [...] |
| EFHD2 protein network | https://string-db.org/network/9606.ENSP00000365147 | EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating b [...] |
| ISCA1 protein network | https://string-db.org/network/9606.ENSP00000365159 | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved [...] |
| NUDT11 protein network | https://string-db.org/network/9606.ENSP00000365160 | Diphosphoinositol polyphosphate phosphohydrolase 3-beta; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role [...] |
| MYLK2 protein network | https://string-db.org/network/9606.ENSP00000365162 | Myosin light chain kinase 2, skeletal/cardiac muscle; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N- terminus of a myosin li [...] |
| KDELC1 protein network | https://string-db.org/network/9606.ENSP00000365172 | KDEL motif-containing protein 1; Glycosyltransferase family 90; Belongs to the KDELC family |
| NUDT10 protein network | https://string-db.org/network/9606.ENSP00000365174 | Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a rol [...] |
| SHROOM4 protein network | https://string-db.org/network/9606.ENSP00000365188 | Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distrib [...] |
| KAZN protein network | https://string-db.org/network/9606.ENSP00000365198 | Kazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known; Sterile alpha m [...] |
| TEX30 protein network | https://string-db.org/network/9606.ENSP00000365200 | Testis-expressed protein 30; Testis expressed 30 |
| PRRC2A protein network | https://string-db.org/network/9606.ENSP00000365201 | Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing |
| CCNB3 protein network | https://string-db.org/network/9606.ENSP00000365210 | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via t [...] |
| AIF1 protein network | https://string-db.org/network/9606.ENSP00000365227 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signali [...] |
| TPP2 protein network | https://string-db.org/network/9606.ENSP00000365233 | Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to [...] |
| COX4I2 protein network | https://string-db.org/network/9606.ENSP00000365243 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transp [...] |
| LRRC38 protein network | https://string-db.org/network/9606.ENSP00000365253 | Leucine-rich repeat-containing protein 38; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...] |
| ANKRD26 protein network | https://string-db.org/network/9606.ENSP00000365255 | Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior; Ankyrin repeat domain containing |
| CLCN5 protein network | https://string-db.org/network/9606.ENSP00000365256 | H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosom [...] |
| LST1 protein network | https://string-db.org/network/9606.ENSP00000365261 | Leukocyte-specific transcript 1 protein; Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a vari [...] |
| PRAMEF17 protein network | https://string-db.org/network/9606.ENSP00000365266 | PRAME family member 17; Belongs to the PRAME family |
| PRAMEF19 protein network | https://string-db.org/network/9606.ENSP00000365269 | PRAME family member 19 |
| DLG2 protein network | https://string-db.org/network/9606.ENSP00000365272 | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts [...] |
| ID1 protein network | https://string-db.org/network/9606.ENSP00000365280 | DNA-binding protein inhibitor ID-1; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...] |
| FAM181B protein network | https://string-db.org/network/9606.ENSP00000365295 | Protein FAM181B; Family with sequence similarity 181 member B; Belongs to the FAM181 family |
| FGF14 protein network | https://string-db.org/network/9606.ENSP00000365301 | Fibroblast growth factor 14; Probably involved in nervous system development and function; Belongs to the heparin-binding growth factors family |
| ABI1 protein network | https://string-db.org/network/9606.ENSP00000365312 | Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced [...] |
| NFKBIL1 protein network | https://string-db.org/network/9606.ENSP00000365318 | NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathw [...] |
| PAGE1 protein network | https://string-db.org/network/9606.ENSP00000365320 | PAGE family member 1 |
| PRAMEF9 protein network | https://string-db.org/network/9606.ENSP00000365322 | PRAME family member 9; Belongs to the PRAME family |
| ITGBL1 protein network | https://string-db.org/network/9606.ENSP00000365351 | Integrin subunit beta like 1 |
| PRAMEF6 protein network | https://string-db.org/network/9606.ENSP00000365360 | PRAME family member 6; Belongs to the PRAME family |
| MCCD1 protein network | https://string-db.org/network/9606.ENSP00000365362 | Mitochondrial coiled-coil domain 1 |
| FOXP3 protein network | https://string-db.org/network/9606.ENSP00000365380 | Forkhead box protein P3; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of [...] |
| PDSS1 protein network | https://string-db.org/network/9606.ENSP00000365388 | Decaprenyl-diphosphate synthase subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10; Belongs to the FPP/GGPP synthase family |
| AADACL4 protein network | https://string-db.org/network/9606.ENSP00000365395 | Arylacetamide deacetylase-like 4; Arylacetamide deacetylase family |
| CCDC22 protein network | https://string-db.org/network/9606.ENSP00000365401 | Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation lead [...] |
| HLA-C protein network | https://string-db.org/network/9606.ENSP00000365402 | HLA class I histocompatibility antigen, Cw-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family |
| ZNF549 protein network | https://string-db.org/network/9606.ENSP00000365407 | Zinc finger protein 549; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| APBB1IP protein network | https://string-db.org/network/9606.ENSP00000365411 | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses in [...] |
| SLC28A3 protein network | https://string-db.org/network/9606.ENSP00000365413 | Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleos [...] |
| GGACT protein network | https://string-db.org/network/9606.ENSP00000365426 | Gamma-glutamylaminecyclotransferase; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes t [...] |
| TCF19 protein network | https://string-db.org/network/9606.ENSP00000365433 | Transcription factor 19; Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression; PHD finger prot [...] |
| TNFRSF1B protein network | https://string-db.org/network/9606.ENSP00000365435 | Tumor necrosis factor receptor superfamily member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1 [...] |
| GAD2 protein network | https://string-db.org/network/9606.ENSP00000365437 | Glutamate decarboxylase 2; Catalyzes the production of GABA |
| HNRNPK protein network | https://string-db.org/network/9606.ENSP00000365439 | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particula [...] |
| CACNA1F protein network | https://string-db.org/network/9606.ENSP00000365441 | Voltage-dependent L-type calcium channel subunit alpha-1F; Isoform 1: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a v [...] |
| OR4D1 protein network | https://string-db.org/network/9606.ENSP00000365451 | Olfactory receptor 4D1; Odorant receptor; Olfactory receptors, family 4 |
| PCCA protein network | https://string-db.org/network/9606.ENSP00000365462 | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isole [...] |
| CDSN protein network | https://string-db.org/network/9606.ENSP00000365465 | Corneodesmosin; Important for the epidermal barrier integrity |
| MUC21 protein network | https://string-db.org/network/9606.ENSP00000365473 | Mucin-21; Mucin 21, cell surface associated; Mucins |
| CCDC93 protein network | https://string-db.org/network/9606.ENSP00000365477 | Coiled-coil domain-containing protein 93; Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on [...] |
| DEFB123 protein network | https://string-db.org/network/9606.ENSP00000365486 | Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family |
| DEFB119 protein network | https://string-db.org/network/9606.ENSP00000365492 | Defensin beta 119 |
| SHISA7 protein network | https://string-db.org/network/9606.ENSP00000365503 | Protein shisa-7; Shisa family member 7 |
| PLP2 protein network | https://string-db.org/network/9606.ENSP00000365505 | Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium |
| ZIC2 protein network | https://string-db.org/network/9606.ENSP00000365514 | Zinc finger protein ZIC 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin tra [...] |
| C9orf64 protein network | https://string-db.org/network/9606.ENSP00000365522 | Queuosine salvage protein; Involved in salvaging queuosine |
| PTPRH protein network | https://string-db.org/network/9606.ENSP00000365528 | Receptor-type tyrosine-protein phosphatase H; Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associ [...] |
| GPR158 protein network | https://string-db.org/network/9606.ENSP00000365529 | Probable G-protein coupled receptor 158; Orphan receptor; G protein-coupled receptors, Class C orphans |
| STXBP4 protein network | https://string-db.org/network/9606.ENSP00000365530 | Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to [...] |
| CLYBL protein network | https://string-db.org/network/9606.ENSP00000365533 | Citramalyl-CoA lyase, mitochondrial; Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5- dicarbox [...] |
| ENSG00000250232 protein network | https://string-db.org/network/9606.ENSP00000365536 | PRA1 family protein; Uncharacterized protein; WD repeat domain phosphoinositide-interacting protein 4 |
| GKAP1 protein network | https://string-db.org/network/9606.ENSP00000365550 | G kinase anchoring protein 1; Belongs to the GKAP1 family |
| TM9SF2 protein network | https://string-db.org/network/9606.ENSP00000365567 | Transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter; Transmembrane 9 superfamily members |
| FLOT1 protein network | https://string-db.org/network/9606.ENSP00000365569 | Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles; Flotillins |
| UBQLN1 protein network | https://string-db.org/network/9606.ENSP00000365576 | Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum- [...] |
| FAM182B protein network | https://string-db.org/network/9606.ENSP00000365585 | Protein FAM182B; Family with sequence similarity 182 member B |
| MDC1 protein network | https://string-db.org/network/9606.ENSP00000365588 | Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a [...] |
| GPR183 protein network | https://string-db.org/network/9606.ENSP00000365596 | G-protein coupled receptor 183; G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and as [...] |
| IDNK protein network | https://string-db.org/network/9606.ENSP00000365601 | IDNK, gluconokinase |
| GRIPAP1 protein network | https://string-db.org/network/9606.ENSP00000365606 | GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of [...] |
| ZNF337 protein network | https://string-db.org/network/9606.ENSP00000365619 | Zinc finger protein 337; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| DHX16 protein network | https://string-db.org/network/9606.ENSP00000365625 | Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. DDX16 [...] |
| RASEF protein network | https://string-db.org/network/9606.ENSP00000365630 | Ras and EF-hand domain-containing protein; Binds predominantly GDP, and also GTP; EF-hand domain containing |
| KIAA1217 protein network | https://string-db.org/network/9606.ENSP00000365637 | Sickle tail protein homolog; Required for normal development of intervertebral disks |
| DOCK9 protein network | https://string-db.org/network/9606.ENSP00000365643 | Dedicator of cytokinesis protein 9; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation; Belongs to the [...] |
| NPPB protein network | https://string-db.org/network/9606.ENSP00000365651 | Natriuretic peptides B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vaso [...] |
| NPPA protein network | https://string-db.org/network/9606.ENSP00000365663 | Natriuretic peptides A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting [...] |
| OTUD1 protein network | https://string-db.org/network/9606.ENSP00000365678 | OTU domain-containing protein 1; Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin; OTU domain containing |
| TLE1 protein network | https://string-db.org/network/9606.ENSP00000365682 | Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activa [...] |
| SLC15A1 protein network | https://string-db.org/network/9606.ENSP00000365686 | Solute carrier family 15 member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digest [...] |
| PTF1A protein network | https://string-db.org/network/9606.ENSP00000365687 | Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role i [...] |
| PIM2 protein network | https://string-db.org/network/9606.ENSP00000365692 | Serine/threonine-protein kinase pim-2; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation [...] |
| MSRB2 protein network | https://string-db.org/network/9606.ENSP00000365693 | Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation [...] |
| PPP1R10 protein network | https://string-db.org/network/9606.ENSP00000365694 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of [...] |
| TTYH1 protein network | https://string-db.org/network/9606.ENSP00000365714 | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity) |
| TLE4 protein network | https://string-db.org/network/9606.ENSP00000365720 | Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF fa [...] |
| ABHD12 protein network | https://string-db.org/network/9606.ENSP00000365725 | Monoacylglycerol lipase ABHD12; Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain (By similarity). May also have [...] |
| STK24 protein network | https://string-db.org/network/9606.ENSP00000365730 | Serine/threonine-protein kinase 24; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Me [...] |
| PRR3 protein network | https://string-db.org/network/9606.ENSP00000365744 | Proline-rich protein 3; Zinc fingers CCCH-type |
| CTTN protein network | https://string-db.org/network/9606.ENSP00000365745 | Contributes to the organization of the actin cytoskeleton and cell shape . Plays a role in the formation of lamellipodia and in cell migration. Plays a role in the regulation of neuron morphology [...] |
| KIAA2013 protein network | https://string-db.org/network/9606.ENSP00000365756 | Uncharacterized protein KIAA2013; KIAA2013 |
| PIP4K2A protein network | https://string-db.org/network/9606.ENSP00000365757 | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phos [...] |
| PSAT1 protein network | https://string-db.org/network/9606.ENSP00000365773 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belon [...] |
| MTHFR protein network | https://string-db.org/network/9606.ENSP00000365777 | Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co- substrate for homocysteine remethylation to methionine |
| CEP78 protein network | https://string-db.org/network/9606.ENSP00000365782 | Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis |
| GNL1 protein network | https://string-db.org/network/9606.ENSP00000365806 | Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster |
| GNA14 protein network | https://string-db.org/network/9606.ENSP00000365807 | Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; G prote [...] |
| SPAG6 protein network | https://string-db.org/network/9606.ENSP00000365811 | Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility; Armadillo repeat containing |
| HLA-E protein network | https://string-db.org/network/9606.ENSP00000365817 | HLA class I histocompatibility antigen, alpha chain E; Preferably binds to a peptide derived from the signal sequence of most HLA-A, -B, -C and -G molecules; Belongs to the MHC class I family |
| SOWAHC protein network | https://string-db.org/network/9606.ENSP00000365830 | Ankyrin repeat domain-containing protein SOWAHC; Sosondowah ankyrin repeat domain family member C; Belongs to the SOWAH family |
| PUS1 protein network | https://string-db.org/network/9606.ENSP00000365837 | tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an [...] |
| DPRX protein network | https://string-db.org/network/9606.ENSP00000365838 | Divergent paired-related homeobox; Putative transcription factor; PRD class homeoboxes and pseudogenes |
| ENTPD6 protein network | https://string-db.org/network/9606.ENSP00000365840 | Ectonucleoside triphosphate diphosphohydrolase 6; Might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleo [...] |
| TRIM39 protein network | https://string-db.org/network/9606.ENSP00000365844 | E3 ubiquitin-protein ligase TRIM39; E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of t [...] |
| BMI1 protein network | https://string-db.org/network/9606.ENSP00000365851 | Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, inc [...] |
| GATA1 protein network | https://string-db.org/network/9606.ENSP00000365858 | Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequenc [...] |
| NUDT8 protein network | https://string-db.org/network/9606.ENSP00000365883 | Nucleoside diphosphate-linked moiety X motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Nudix hydrolase family |
| TRIM15 protein network | https://string-db.org/network/9606.ENSP00000365884 | Tripartite motif containing 15; Belongs to the TRIM/RBCC family |
| WAS protein network | https://string-db.org/network/9606.ENSP00000365891 | Wiskott-Aldrich syndrome protein; Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymer [...] |
| HS6ST3 protein network | https://string-db.org/network/9606.ENSP00000365895 | Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...] |
| FOXB2 protein network | https://string-db.org/network/9606.ENSP00000365898 | Forkhead box protein B2; Transcription factor; Forkhead boxes |
| VSX1 protein network | https://string-db.org/network/9606.ENSP00000365899 | Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at [...] |
| PRUNE2 protein network | https://string-db.org/network/9606.ENSP00000365908 | Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells; BCH domain containing |
| WDR13 protein network | https://string-db.org/network/9606.ENSP00000365919 | WD repeat-containing protein 13; WD repeat domain containing |
| TRIM31 protein network | https://string-db.org/network/9606.ENSP00000365924 | E3 ubiquitin-protein ligase TRIM31; Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity; Ring finger proteins |
| RFK protein network | https://string-db.org/network/9606.ENSP00000365926 | Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reac [...] |
| SP2 protein network | https://string-db.org/network/9606.ENSP00000365931 | Transcription factor Sp2; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites; Belongs to the Sp1 C2H2-type zinc-finge [...] |
| UGGT2 protein network | https://string-db.org/network/9606.ENSP00000365938 | UDP-glucose:glycoprotein glucosyltransferase 2; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality [...] |
| FBXO6 protein network | https://string-db.org/network/9606.ENSP00000365944 | F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway ( [...] |
| RBM3 protein network | https://string-db.org/network/9606.ENSP00000365950 | RNA-binding protein 3; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microR [...] |
| FBXO44 protein network | https://string-db.org/network/9606.ENSP00000365961 | F-box only protein 44; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| TBC1D25 protein network | https://string-db.org/network/9606.ENSP00000365962 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endoso [...] |
| PPP1R11 protein network | https://string-db.org/network/9606.ENSP00000365963 | Protein phosphatase 1 regulatory subunit 11; Inhibitor of protein phosphatase 1; Cilia and flagella associated |
| UBIAD1 protein network | https://string-db.org/network/9606.ENSP00000366006 | UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrat [...] |
| ANGPTL7 protein network | https://string-db.org/network/9606.ENSP00000366015 | Angiopoietin-related protein 7; Fibrinogen C domain containing; Angiopoietin like |
| C9orf41 protein network | https://string-db.org/network/9606.ENSP00000366030 | Carnosine N-methyltransferase; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (b [...] |
| COMMD3 protein network | https://string-db.org/network/9606.ENSP00000366032 | COMM domain-containing protein 3; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cel [...] |
| TBC1D8 protein network | https://string-db.org/network/9606.ENSP00000366036 | TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s); GRAM domain containing |
| KLK6 protein network | https://string-db.org/network/9606.ENSP00000366047 | Kallikrein-6; Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, my [...] |
| C9orf40 protein network | https://string-db.org/network/9606.ENSP00000366050 | Uncharacterized protein C9orf40; Chromosome 9 open reading frame 40 |
| SYNDIG1 protein network | https://string-db.org/network/9606.ENSP00000366058 | Synapse differentiation-inducing gene protein 1; May regulate AMPA receptor content at nascent synapses, and have a role in postsynaptic development and maturation; Belongs to the CD225/Dispanin [...] |
| NMS protein network | https://string-db.org/network/9606.ENSP00000366061 | Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Endogenous ligands |
| RILPL1 protein network | https://string-db.org/network/9606.ENSP00000366070 | RILP-like protein 1; Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective pr [...] |
| ABCC4 protein network | https://string-db.org/network/9606.ENSP00000366084 | Multidrug resistance-associated protein 4; May be an organic anion pump relevant to cellular detoxification; ATP binding cassette subfamily C |
| RORB protein network | https://string-db.org/network/9606.ENSP00000366093 | Nuclear receptor ROR-beta; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence [...] |
| MOG protein network | https://string-db.org/network/9606.ENSP00000366095 | Myelin-oligodendrocyte glycoprotein; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin s [...] |
| YIF1A protein network | https://string-db.org/network/9606.ENSP00000366098 | Protein YIF1A; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the YIF1 family |
| ANXA1 protein network | https://string-db.org/network/9606.ENSP00000366109 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a [...] |
| SSX1 protein network | https://string-db.org/network/9606.ENSP00000366118 | Protein SSX1; Could act as a modulator of transcription; Belongs to the SSX family |
| EXOSC10 protein network | https://string-db.org/network/9606.ENSP00000366135 | Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation [...] |
| SOX21 protein network | https://string-db.org/network/9606.ENSP00000366144 | Transcription factor SOX-21; May play a role as an activator of transcription of OPRM1; SRY-boxes |
| ZNF81 protein network | https://string-db.org/network/9606.ENSP00000366153 | Zinc finger protein 81; May be involved in transcriptional regulation; X-linked mental retardation |
| SRM protein network | https://string-db.org/network/9606.ENSP00000366156 | Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low [...] |
| GPR180 protein network | https://string-db.org/network/9606.ENSP00000366157 | Integral membrane protein GPR180; G protein-coupled receptor 180 |
| CST9 protein network | https://string-db.org/network/9606.ENSP00000366170 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Franc [...] |
| CBY3 protein network | https://string-db.org/network/9606.ENSP00000366173 | Chibby family member 3 |
| CST9L protein network | https://string-db.org/network/9606.ENSP00000366178 | Cystatin-9-like; Cystatins, type 2; Belongs to the cystatin family |
| DNAJC1 protein network | https://string-db.org/network/9606.ENSP00000366179 | DnaJ homolog subfamily C member 1; May modulate protein synthesis; DNAJ heat shock proteins |
| C1orf127 protein network | https://string-db.org/network/9606.ENSP00000366203 | Uncharacterized protein C1orf127; Chromosome 1 open reading frame 127 |
| CST11 protein network | https://string-db.org/network/9606.ENSP00000366208 | Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization; Belongs to the cystatin family |
| CASZ1 protein network | https://string-db.org/network/9606.ENSP00000366221 | Zinc finger protein castor homolog 1; Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7; Zinc fingers C2H2-type |
| C9orf57 protein network | https://string-db.org/network/9606.ENSP00000366223 | Uncharacterized protein C9orf57; Chromosome 9 open reading frame 57 |
| GABBR1 protein network | https://string-db.org/network/9606.ENSP00000366233 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABB [...] |
| IL31 protein network | https://string-db.org/network/9606.ENSP00000366234 | Interleukin-31; Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. May function in skin immunity. Enhances myeloid progenitor cell s [...] |
| DFFA protein network | https://string-db.org/network/9606.ENSP00000366237 | DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40) |
| ABHD17B protein network | https://string-db.org/network/9606.ENSP00000366240 | Protein ABHD17B; Abhydrolase domain containing 17B; Belongs to the AB hydrolase superfamily. ABHD17 family |
| TMEM2 protein network | https://string-db.org/network/9606.ENSP00000366243 | Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kD [...] |
| GPC6 protein network | https://string-db.org/network/9606.ENSP00000366246 | Glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). [...] |
| CORT protein network | https://string-db.org/network/9606.ENSP00000366248 | Cortistatin; Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs; Endogenous ligands |
| UBD protein network | https://string-db.org/network/9606.ENSP00000366249 | Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Prob [...] |
| ZNF41 protein network | https://string-db.org/network/9606.ENSP00000366265 | Zinc finger protein 41; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| GPC5 protein network | https://string-db.org/network/9606.ENSP00000366267 | Glypican-5; Cell surface proteoglycan that bears heparan sulfate; Belongs to the glypican family |
| KDM2B protein network | https://string-db.org/network/9606.ENSP00000366271 | Lysine-specific demethylase 2B; Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylate [...] |
| ZNF157 protein network | https://string-db.org/network/9606.ENSP00000366273 | Zinc finger protein 157; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CNNM4 protein network | https://string-db.org/network/9606.ENSP00000366275 | Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a ro [...] |
| LMAN2L protein network | https://string-db.org/network/9606.ENSP00000366280 | VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 |
| SLITRK5 protein network | https://string-db.org/network/9606.ENSP00000366283 | SLIT and NTRK-like protein 5; Suppresses neurite outgrowth; Belongs to the SLITRK family |
| SLITRK1 protein network | https://string-db.org/network/9606.ENSP00000366288 | SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation. Enhances neuronal dendrite outgrowth |
| SLC25A39 protein network | https://string-db.org/network/9606.ENSP00000366299 | Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| SPRY2 protein network | https://string-db.org/network/9606.ENSP00000366306 | Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family |
| THBD protein network | https://string-db.org/network/9606.ENSP00000366307 | Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the ac [...] |
| TRPM3 protein network | https://string-db.org/network/9606.ENSP00000366314 | Transient receptor potential cation channel subfamily M member 3; Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by [...] |
| CASC10 protein network | https://string-db.org/network/9606.ENSP00000366317 | Protein CASC10; Cancer susceptibility 10 |
| NEBL protein network | https://string-db.org/network/9606.ENSP00000366326 | Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. Is [...] |
| KLF9 protein network | https://string-db.org/network/9606.ENSP00000366330 | Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with [...] |
| MAS1L protein network | https://string-db.org/network/9606.ENSP00000366331 | Mas-related G-protein coupled receptor MRG; MAS1 proto-oncogene like, G protein-coupled receptor |
| OR2H1 protein network | https://string-db.org/network/9606.ENSP00000366340 | Olfactory receptor 2H1; Odorant receptor; Olfactory receptors, family 2 |
| NKX2-2 protein network | https://string-db.org/network/9606.ENSP00000366347 | Homeobox protein Nkx-2.2; Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in spe [...] |
| OR11A1 protein network | https://string-db.org/network/9606.ENSP00000366354 | Olfactory receptor 11A1; Odorant receptor; Olfactory receptors, family 11 |
| OR5V1 protein network | https://string-db.org/network/9606.ENSP00000366359 | Olfactory receptor 5V1; Odorant receptor; Olfactory receptors, family 5 |
| OR14J1 protein network | https://string-db.org/network/9606.ENSP00000366365 | Olfactory receptor 14J1; Odorant receptor; Olfactory receptors, family 14 |
| OR2J2 protein network | https://string-db.org/network/9606.ENSP00000366372 | Olfactory receptor 2J2; Odorant receptor; Olfactory receptors, family 2 |
| OR2J3 protein network | https://string-db.org/network/9606.ENSP00000366374 | Olfactory receptor 2J3; Odorant receptor involved in the detection of the flavor compound cis-3-hexen-1-ol (C3HEX), a compound typically described as 'green grassy' or the smell of 'cut grass'; O [...] |
| OR2B3 protein network | https://string-db.org/network/9606.ENSP00000366378 | Putative olfactory receptor 2B3; Odorant receptor; Olfactory receptors, family 2 |
| OR2W1 protein network | https://string-db.org/network/9606.ENSP00000366380 | Olfactory receptor 2W1; Odorant receptor; Olfactory receptors, family 2 |
| ZNF311 protein network | https://string-db.org/network/9606.ENSP00000366384 | Zinc finger protein 311; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MAMDC2 protein network | https://string-db.org/network/9606.ENSP00000366387 | MAM domain containing 2 |
| SPDYC protein network | https://string-db.org/network/9606.ENSP00000366390 | Speedy protein C; Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 a [...] |
| SYVN1 protein network | https://string-db.org/network/9606.ENSP00000366395 | E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substr [...] |
| XRN2 protein network | https://string-db.org/network/9606.ENSP00000366396 | 5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage a [...] |
| C9orf135 protein network | https://string-db.org/network/9606.ENSP00000366402 | Protein C9orf135; Chromosome 9 open reading frame 135 |
| TRIM27 protein network | https://string-db.org/network/9606.ENSP00000366404 | Zinc finger protein RFP; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the functio [...] |
| NMNAT1 protein network | https://string-db.org/network/9606.ENSP00000366410 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic aci [...] |
| POU4F1 protein network | https://string-db.org/network/9606.ENSP00000366413 | POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences [...] |
| EDNRB protein network | https://string-db.org/network/9606.ENSP00000366416 | Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger syst [...] |
| LZIC protein network | https://string-db.org/network/9606.ENSP00000366430 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing |
| UIMC1 protein network | https://string-db.org/network/9606.ENSP00000366434 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63' [...] |
| SNX15 protein network | https://string-db.org/network/9606.ENSP00000366452 | Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosom [...] |
| PLXDC2 protein network | https://string-db.org/network/9606.ENSP00000366460 | Plexin domain-containing protein 2; May play a role in tumor angiogenesis; Belongs to the plexin family |
| ZKSCAN3 protein network | https://string-db.org/network/9606.ENSP00000366465 | Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses [...] |
| CTNNBIP1 protein network | https://string-db.org/network/9606.ENSP00000366474 | Beta-catenin-interacting protein 1; Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway; Belongs to the CTNNBIP1 family |
| ATG2A protein network | https://string-db.org/network/9606.ENSP00000366475 | Autophagy-related protein 2 homolog A; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion; Belongs to the ATG2 family |
| FXN protein network | https://string-db.org/network/9606.ENSP00000366482 | Frataxin, mitochondrial; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the prot [...] |
| ARL5B protein network | https://string-db.org/network/9606.ENSP00000366487 | ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP; ARF GTPase family |
| PRKACG protein network | https://string-db.org/network/9606.ENSP00000366488 | cAMP-dependent protein kinase catalytic subunit gamma; Phosphorylates a large number of substrates in the cytoplasm and the nucleus; Belongs to the protein kinase superfamily. AGC Ser/Thr protein [...] |
| HRH2 protein network | https://string-db.org/network/9606.ENSP00000366506 | Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regula [...] |
| ZKSCAN4 protein network | https://string-db.org/network/9606.ENSP00000366509 | Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CLSTN1 protein network | https://string-db.org/network/9606.ENSP00000366513 | Calsyntenin-1; Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- [...] |
| NSUN6 protein network | https://string-db.org/network/9606.ENSP00000366519 | Putative methyltransferase NSUN6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family |
| ARHGAP39 protein network | https://string-db.org/network/9606.ENSP00000366522 | Rho GTPase activating protein 39 |
| FTL protein network | https://string-db.org/network/9606.ENSP00000366525 | Ferritin light chain; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after ox [...] |
| ZSCAN16 protein network | https://string-db.org/network/9606.ENSP00000366527 | Zinc finger and SCAN domain-containing protein 16; May be involved in transcriptional regulation; SCAN domain containing |
| TMEM252 protein network | https://string-db.org/network/9606.ENSP00000366528 | Transmembrane protein 252 |
| FOXH1 protein network | https://string-db.org/network/9606.ENSP00000366534 | Forkhead box protein H1; Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin si [...] |
| ZNF165 protein network | https://string-db.org/network/9606.ENSP00000366542 | Zinc finger protein 165; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ST3GAL5 protein network | https://string-db.org/network/9606.ENSP00000366549 | Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide); Sialyltransferases |
| CRNKL1 protein network | https://string-db.org/network/9606.ENSP00000366557 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process; Belongs to the crooked-neck family |
| PIK3CD protein network | https://string-db.org/network/9606.ENSP00000366563 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to gene [...] |
| VPS28 protein network | https://string-db.org/network/9606.ENSP00000366565 | Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process |
| FAM196B protein network | https://string-db.org/network/9606.ENSP00000366582 | Protein FAM196B; Family with sequence similarity 196 member B; Belongs to the FAM196 family |
| SLC39A12 protein network | https://string-db.org/network/9606.ENSP00000366586 | Zinc transporter ZIP12; Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia; Belongs to the ZIP transporter (TC 2.A.5) family |
| SF1 protein network | https://string-db.org/network/9606.ENSP00000366604 | Splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repr [...] |
| CBWD7 protein network | https://string-db.org/network/9606.ENSP00000366608 | COBW domain-containing protein 6; COBW domain containing 7; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily |
| CBWD5 protein network | https://string-db.org/network/9606.ENSP00000366612 | COBW domain-containing protein 3; COBW domain containing 5 |
| CBWD1 protein network | https://string-db.org/network/9606.ENSP00000366617 | COBW domain containing 1 |
| HIST1H2BL protein network | https://string-db.org/network/9606.ENSP00000366618 | Histone H2B type 1-L; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| GPR157 protein network | https://string-db.org/network/9606.ENSP00000366628 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activat [...] |
| FOXD4L4 protein network | https://string-db.org/network/9606.ENSP00000366630 | Forkhead box D4 like 4 |
| FOXD4L5 protein network | https://string-db.org/network/9606.ENSP00000366637 | Forkhead box D4 like 5 |
| SLC2A5 protein network | https://string-db.org/network/9606.ENSP00000366641 | Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of 2-deoxygluc [...] |
| SCP2D1 protein network | https://string-db.org/network/9606.ENSP00000366645 | SCP2 sterol-binding domain-containing protein 1; SCP2 sterol binding domain containing 1 |
| CA6 protein network | https://string-db.org/network/9606.ENSP00000366654 | Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown; Carbonic anhydrases |
| DTD1 protein network | https://string-db.org/network/9606.ENSP00000366672 | D-aminoacyl-tRNA deacylase 1; Possible ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes |
| CLN5 protein network | https://string-db.org/network/9606.ENSP00000366673 | Ceroid-lipofuscinosis neuronal protein 5; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by co [...] |
| HIST1H2AH protein network | https://string-db.org/network/9606.ENSP00000366679 | Histone H2A type 1-H; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| IRG1 protein network | https://string-db.org/network/9606.ENSP00000366682 | Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)- mediated inflammatory innate response by stim [...] |
| SPATC1 protein network | https://string-db.org/network/9606.ENSP00000366690 | Speriolin; Spermatogenesis and centriole associated 1; Belongs to the speriolin family |
| KCTD12 protein network | https://string-db.org/network/9606.ENSP00000366694 | BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...] |
| ERRFI1 protein network | https://string-db.org/network/9606.ENSP00000366702 | ERBB receptor feedback inhibitor 1; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inh [...] |
| TMEM236 protein network | https://string-db.org/network/9606.ENSP00000366715 | Transmembrane protein 236 |
| STAM protein network | https://string-db.org/network/9606.ENSP00000366746 | Signal transducing adapter molecule 1; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leadi [...] |
| AUP1 protein network | https://string-db.org/network/9606.ENSP00000366748 | AUP1, lipid droplet regulating VLDL assembly factor |
| LBX2 protein network | https://string-db.org/network/9606.ENSP00000366789 | Transcription factor LBX2; Putative transcription factor; NKL subclass homeoboxes and pseudogenes |
| SLC22A12 protein network | https://string-db.org/network/9606.ENSP00000366797 | Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate a [...] |
| HMGN4 protein network | https://string-db.org/network/9606.ENSP00000366798 | High mobility group nucleosomal binding domain 4; Belongs to the HMGN family |
| DNAJC11 protein network | https://string-db.org/network/9606.ENSP00000366800 | DnaJ homolog subfamily C member 11; Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer [...] |
| UCHL3 protein network | https://string-db.org/network/9606.ENSP00000366819 | Ubiquitin carboxyl-terminal hydrolase isozyme L3; Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. T [...] |
| ANKRD20A2 protein network | https://string-db.org/network/9606.ENSP00000366826 | Ankyrin repeat domain-containing protein 20A2; Ankyrin repeat domain 20 family member A2 |
| ST8SIA6 protein network | https://string-db.org/network/9606.ENSP00000366827 | Alpha-2,8-sialyltransferase 8F; Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc- alpha-2,3(6)-Gal sequence at the non-reducing en [...] |
| POLR3F protein network | https://string-db.org/network/9606.ENSP00000366828 | DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| ATXN2 protein network | https://string-db.org/network/9606.ENSP00000366843 | Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane; Ataxins |
| TBC1D4 protein network | https://string-db.org/network/9606.ENSP00000366863 | TBC1 domain family member 4; May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the pla [...] |
| SPATA31A1 protein network | https://string-db.org/network/9606.ENSP00000366875 | Spermatogenesis-associated protein 31A1; May play a role in spermatogenesis |
| PHF13 protein network | https://string-db.org/network/9606.ENSP00000366876 | PHD finger protein 13; Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis; PHD [...] |
| KLHL21 protein network | https://string-db.org/network/9606.ENSP00000366886 | Kelch-like protein 21; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiq [...] |
| KLF12 protein network | https://string-db.org/network/9606.ENSP00000366897 | Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter; Belongs to the Sp1 C2H2-type zinc- [...] |
| HIF3A protein network | https://string-db.org/network/9606.ENSP00000366898 | Hypoxia-inducible factor 3-alpha; Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-indu [...] |
| FAM216A protein network | https://string-db.org/network/9606.ENSP00000366901 | Protein FAM216A; Family with sequence similarity 216 member A; Belongs to the FAM216 family |
| ZBTB48 protein network | https://string-db.org/network/9606.ENSP00000366902 | Telomere zinc finger-associated protein; Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially bin [...] |
| KLF5 protein network | https://string-db.org/network/9606.ENSP00000366915 | Krueppel-like factor 5; Transcription factor that binds to GC box promoter elements. Activates the transcription of these genes; Kruppel like factors |
| IGFBPL1 protein network | https://string-db.org/network/9606.ENSP00000366923 | Insulin-like growth factor-binding protein-like 1; IGF-binding proteins prolong the half-life of IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs i [...] |
| ALDH1B1 protein network | https://string-db.org/network/9606.ENSP00000366927 | Aldehyde dehydrogenase X, mitochondrial; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, ne [...] |
| NOL9 protein network | https://string-db.org/network/9606.ENSP00000366934 | Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more [...] |
| SHB protein network | https://string-db.org/network/9606.ENSP00000366936 | SH2 domain-containing adapter protein B; Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in [...] |
| MGME1 protein network | https://string-db.org/network/9606.ENSP00000366939 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity [...] |
| SLC36A3 protein network | https://string-db.org/network/9606.ENSP00000366942 | Proton-coupled amino acid transporter 3; Solute carrier family 36 member 3 |
| SLC25A51 protein network | https://string-db.org/network/9606.ENSP00000366945 | Solute carrier family 25 member 51 |
| KRTAP9-2 protein network | https://string-db.org/network/9606.ENSP00000366950 | Keratin-associated protein 9-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| DCAF10 protein network | https://string-db.org/network/9606.ENSP00000366953 | DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| KRTAP4-2 protein network | https://string-db.org/network/9606.ENSP00000366955 | Keratin-associated protein 4-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| HIST1H4H protein network | https://string-db.org/network/9606.ENSP00000366956 | Histone cluster 1 H4 family member h; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| HIST1H2BI protein network | https://string-db.org/network/9606.ENSP00000366962 | Histone cluster 1 H2B family member i; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| GPR20 protein network | https://string-db.org/network/9606.ENSP00000366970 | G-protein coupled receptor 20; Orphan receptor with constitutive G(i) signaling activity that activate cyclic AMP; G protein-coupled receptors, Class A orphans |
| HIST1H4B protein network | https://string-db.org/network/9606.ENSP00000366974 | Histone cluster 1 H4 family member b; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| KRTAP1-4 protein network | https://string-db.org/network/9606.ENSP00000366976 | Keratin-associated protein 1-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRT40 protein network | https://string-db.org/network/9606.ENSP00000366984 | Keratin, type I cytoskeletal 40; May play a role in late hair differentiation; Belongs to the intermediate filament family |
| DIS3 protein network | https://string-db.org/network/9606.ENSP00000366997 | Exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and [...] |
| SNX5 protein network | https://string-db.org/network/9606.ENSP00000366998 | Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphospha [...] |
| HIST1H3D protein network | https://string-db.org/network/9606.ENSP00000366999 | Histone cluster 1 H3 family member d; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| DPP6 protein network | https://string-db.org/network/9606.ENSP00000367001 | Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no [...] |
| TNFRSF25 protein network | https://string-db.org/network/9606.ENSP00000367013 | Tumor necrosis factor receptor superfamily member 25; Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May pla [...] |
| HIST1H2AC protein network | https://string-db.org/network/9606.ENSP00000367022 | Histone H2A type 1-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| NAA40 protein network | https://string-db.org/network/9606.ENSP00000367024 | N-alpha-acetyltransferase 40; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A. In contrast to other N-alpha- acetyltransfera [...] |
| TCOF1 protein network | https://string-db.org/network/9606.ENSP00000367028 | Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neu [...] |
| POLR1E protein network | https://string-db.org/network/9606.ENSP00000367029 | DNA-directed RNA polymerase I subunit RPA49; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| TRDMT1 protein network | https://string-db.org/network/9606.ENSP00000367030 | tRNA (cytosine(38)-C(5))-methyltransferase; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp); Seven-beta-strand methyltransferase motif containing |
| PLCXD3 protein network | https://string-db.org/network/9606.ENSP00000367032 | PI-PLC X domain-containing protein 3; Phosphatidylinositol specific phospholipase C X domain containing 3 |
| HIST1H4C protein network | https://string-db.org/network/9606.ENSP00000367034 | Histone cluster 1 H4 family member c; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| RRBP1 protein network | https://string-db.org/network/9606.ENSP00000367038 | Ribosome-binding protein 1; Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane |
| MZT1 protein network | https://string-db.org/network/9606.ENSP00000367049 | Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome; Belongs to the MOZART1 family |
| RTN3 protein network | https://string-db.org/network/9606.ENSP00000367050 | Reticulon-3; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. [...] |
| ESPN protein network | https://string-db.org/network/9606.ENSP00000367059 | Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechano [...] |
| CUBN protein network | https://string-db.org/network/9606.ENSP00000367064 | Cubilin; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, [...] |
| HES2 protein network | https://string-db.org/network/9606.ENSP00000367065 | Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins |
| ZFAT protein network | https://string-db.org/network/9606.ENSP00000367069 | Zinc finger protein ZFAT; May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulat [...] |
| KLHL1 protein network | https://string-db.org/network/9606.ENSP00000367075 | Kelch-like protein 1; May play a role in organizing the actin cytoskeleton of the brain cells; BTB domain containing |
| SLC17A2 protein network | https://string-db.org/network/9606.ENSP00000367081 | Sodium-dependent phosphate transport protein 3; May be involved in actively transporting phosphate into cells via Na(+) cotransport; Belongs to the major facilitator superfamily. Sodium/anion cot [...] |
| ACOT7 protein network | https://string-db.org/network/9606.ENSP00000367086 | Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...] |
| PCDH9 protein network | https://string-db.org/network/9606.ENSP00000367096 | Protocadherin-9; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| SLC22A6 protein network | https://string-db.org/network/9606.ENSP00000367102 | Solute carrier family 22 member 6; Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic an [...] |
| BFSP1 protein network | https://string-db.org/network/9606.ENSP00000367104 | Filensin; Beaded filament structural protein 1; Belongs to the intermediate filament family |
| SLC3A2 protein network | https://string-db.org/network/9606.ENSP00000367123 | 4F2 cell-surface antigen heavy chain; Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such a [...] |
| GPR153 protein network | https://string-db.org/network/9606.ENSP00000367125 | Probable G-protein coupled receptor 153; Orphan receptor; G protein-coupled receptors, Class A orphans |
| HES3 protein network | https://string-db.org/network/9606.ENSP00000367130 | Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription; Basic helix-loop-helix proteins |
| SLC17A4 protein network | https://string-db.org/network/9606.ENSP00000367137 | Probable small intestine urate exporter; Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate ex [...] |
| SPINK9 protein network | https://string-db.org/network/9606.ENSP00000367139 | Serine protease inhibitor Kazal-type 9; Serine protease inhibitor which specifically inhibits KLK5. May contribute to the regulation of the desquamation process in skin by inhibiting KLK5; Serine [...] |
| PCDH17 protein network | https://string-db.org/network/9606.ENSP00000367151 | Protocadherin-17; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| RSU1 protein network | https://string-db.org/network/9606.ENSP00000367154 | Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro |
| LRRC3C protein network | https://string-db.org/network/9606.ENSP00000367157 | Leucine-rich repeat-containing protein 3C; Leucine rich repeat containing 3C |
| PRR20B protein network | https://string-db.org/network/9606.ENSP00000367163 | Belongs to the PRR20 family |
| PRR20A protein network | https://string-db.org/network/9606.ENSP00000367164 | Proline rich 20A |
| GKN1 protein network | https://string-db.org/network/9606.ENSP00000367172 | Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium; BRICHOS domain containing |
| RNF207 protein network | https://string-db.org/network/9606.ENSP00000367173 | RING finger protein 207; Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export f [...] |
| PCDH8 protein network | https://string-db.org/network/9606.ENSP00000367177 | Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involve [...] |
| LYPD5 protein network | https://string-db.org/network/9606.ENSP00000367185 | LY6/PLAUR domain containing 5 |
| FBXO48 protein network | https://string-db.org/network/9606.ENSP00000367193 | F-box protein 48; F-boxes other |
| GLIPR2 protein network | https://string-db.org/network/9606.ENSP00000367196 | Golgi-associated plant pathogenesis-related protein 1; GLI pathogenesis related 2; CAP superfamily |
| SCGN protein network | https://string-db.org/network/9606.ENSP00000367197 | Secretagogin, EF-hand calcium binding protein; EF-hand domain containing |
| LECT1 protein network | https://string-db.org/network/9606.ENSP00000367198 | Leukocyte cell-derived chemotaxin 1; Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the gro [...] |
| RECK protein network | https://string-db.org/network/9606.ENSP00000367202 | Reversion-inducing cysteine-rich protein with Kazal motifs; Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activi [...] |
| KDM6A protein network | https://string-db.org/network/9606.ENSP00000367203 | Lysine-specific demethylase 6A; Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethyl [...] |
| SUGT1 protein network | https://string-db.org/network/9606.ENSP00000367208 | Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins |
| GRXCR2 protein network | https://string-db.org/network/9606.ENSP00000367214 | Glutaredoxin domain-containing cysteine-rich protein 2; Could play a role in maintaining cochlear stereocilia bundles that are involved in sound detection; Deafness associated genes |
| OR13J1 protein network | https://string-db.org/network/9606.ENSP00000367219 | Olfactory receptor 13J1; Odorant receptor; Olfactory receptors, family 13 |
| ACTR2 protein network | https://string-db.org/network/9606.ENSP00000367220 | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting fact [...] |
| TMEM8B protein network | https://string-db.org/network/9606.ENSP00000367227 | Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion; Belongs to the TMEM8 family |
| CEP68 protein network | https://string-db.org/network/9606.ENSP00000367229 | Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to [...] |
| PTER protein network | https://string-db.org/network/9606.ENSP00000367239 | Phosphotriesterase-related protein; Phosphotriesterase related; Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family |
| AHNAK protein network | https://string-db.org/network/9606.ENSP00000367263 | Neuroblast differentiation-associated protein AHNAK; May be required for neuronal cell differentiation; PDZ domain containing |
| CKAP4 protein network | https://string-db.org/network/9606.ENSP00000367265 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF |
| CKAP2 protein network | https://string-db.org/network/9606.ENSP00000367276 | Cytoskeleton-associated protein 2; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity) |
| FUNDC1 protein network | https://string-db.org/network/9606.ENSP00000367284 | FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control |
| FLRT3 protein network | https://string-db.org/network/9606.ENSP00000367292 | Leucine-rich repeat transmembrane protein FLRT3; Functions in cell-cell adhesion, cell migration and axon guidance, exerting an attractive or repulsive role depending on its interaction partners. [...] |
| VPS36 protein network | https://string-db.org/network/9606.ENSP00000367299 | Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation [...] |
| ZNF425 protein network | https://string-db.org/network/9606.ENSP00000367300 | Zinc finger protein 425; Acts as a transcriptional repressor; Zinc fingers C2H2-type |
| NDP protein network | https://string-db.org/network/9606.ENSP00000367301 | Norrin; Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing [...] |
| MAOB protein network | https://string-db.org/network/9606.ENSP00000367309 | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in th [...] |
| SEL1L2 protein network | https://string-db.org/network/9606.ENSP00000367312 | Protein sel-1 homolog 2; SEL1L2 ERAD E3 ligase adaptor subunit; Belongs to the sel-1 family |
| LRRC10B protein network | https://string-db.org/network/9606.ENSP00000367315 | Leucine-rich repeat-containing protein 10B; Leucine rich repeat containing 10B |
| ITGA8 protein network | https://string-db.org/network/9606.ENSP00000367316 | Integrin alpha-8; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recogni [...] |
| RGP1 protein network | https://string-db.org/network/9606.ENSP00000367318 | RAB6A-GEF complex partner protein 2; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required [...] |
| FBXO47 protein network | https://string-db.org/network/9606.ENSP00000367319 | F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other |
| KCNAB2 protein network | https://string-db.org/network/9606.ENSP00000367323 | Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of ne [...] |
| C12orf73 protein network | https://string-db.org/network/9606.ENSP00000367330 | Uncharacterized protein C12orf73; Chromosome 12 open reading frame 73 |
| GBA2 protein network | https://string-db.org/network/9606.ENSP00000367343 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide (GlcCer) to free glucose and ceramide. Involved in sphingomyelin generation an [...] |
| NDUFAF5 protein network | https://string-db.org/network/9606.ENSP00000367346 | Arginine-hydroxylase NDUFAF5, mitochondrial; Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages. Acts by med [...] |
| C12orf42 protein network | https://string-db.org/network/9606.ENSP00000367353 | Uncharacterized protein C12orf42; Chromosome 12 open reading frame 42 |
| ARHGEF35 protein network | https://string-db.org/network/9606.ENSP00000367355 | Rho guanine nucleotide exchange factor 35 |
| FAM171A1 protein network | https://string-db.org/network/9606.ENSP00000367356 | Protein FAM171A1; Family with sequence similarity 171 member A1 |
| C6orf62 protein network | https://string-db.org/network/9606.ENSP00000367359 | Uncharacterized protein C6orf62; Chromosome 6 open reading frame 62 |
| GPR34 protein network | https://string-db.org/network/9606.ENSP00000367384 | Probable G-protein coupled receptor 34; Orphan receptor; G protein-coupled receptors, Class A orphans |
| PGA4 protein network | https://string-db.org/network/9606.ENSP00000367391 | Pepsin A-4; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family |
| NPHP4 protein network | https://string-db.org/network/9606.ENSP00000367398 | Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis. Required for bu [...] |
| TAF2 protein network | https://string-db.org/network/9606.ENSP00000367406 | Transcription initiation factor TFIID subunit 2; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeri [...] |
| NMT2 protein network | https://string-db.org/network/9606.ENSP00000367407 | Glycylpeptide N-tetradecanoyltransferase 2; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins |
| CASK protein network | https://string-db.org/network/9606.ENSP00000367408 | Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and [...] |
| DLEU1 protein network | https://string-db.org/network/9606.ENSP00000367422 | Leukemia-associated protein 1; May act as a tumor suppressor; Long non-coding RNAs |
| AJAP1 protein network | https://string-db.org/network/9606.ENSP00000367433 | Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration |
| TDP2 protein network | https://string-db.org/network/9606.ENSP00000367440 | Tyrosyl-DNA phosphodiesterase 2; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phospha [...] |
| EXT1 protein network | https://string-db.org/network/9606.ENSP00000367446 | Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appea [...] |
| ACBD7 protein network | https://string-db.org/network/9606.ENSP00000367453 | Acyl-CoA-binding domain-containing protein 7; Binds medium- and long-chain acyl-CoA esters |
| KIAA0319 protein network | https://string-db.org/network/9606.ENSP00000367459 | Dyslexia-associated protein KIAA0319; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a r [...] |
| OLAH protein network | https://string-db.org/network/9606.ENSP00000367462 | S-acyl fatty acid synthase thioesterase, medium chain; oleoyl-ACP hydrolase |
| CEP104 protein network | https://string-db.org/network/9606.ENSP00000367476 | Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip |
| SPIRE2 protein network | https://string-db.org/network/9606.ENSP00000367494 | Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibe [...] |
| LRRC47 protein network | https://string-db.org/network/9606.ENSP00000367498 | Leucine-rich repeat-containing protein 47; Leucine rich repeat containing 47 |
| DCLRE1C protein network | https://string-db.org/network/9606.ENSP00000367527 | Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, [...] |
| AARD protein network | https://string-db.org/network/9606.ENSP00000367528 | Alanine and arginine rich domain containing protein |
| TPM2 protein network | https://string-db.org/network/9606.ENSP00000367542 | Tropomyosin beta chain; Tropomyosin 2; Belongs to the tropomyosin family |
| TP73 protein network | https://string-db.org/network/9606.ENSP00000367545 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block [...] |
| RCBTB1 protein network | https://string-db.org/network/9606.ENSP00000367552 | RCC1 and BTB domain-containing protein 1; May be involved in cell cycle regulation by chromatin remodeling; BTB domain containing |
| C19orf54 protein network | https://string-db.org/network/9606.ENSP00000367564 | UPF0692 protein C19orf54; Chromosome 19 open reading frame 54; Belongs to the UPF0692 family |
| PHF11 protein network | https://string-db.org/network/9606.ENSP00000367570 | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression; PHD finger proteins |
| REEP2 protein network | https://string-db.org/network/9606.ENSP00000367590 | Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By simila [...] |
| TPRG1L protein network | https://string-db.org/network/9606.ENSP00000367595 | Tumor protein p63 regulated 1 like; Belongs to the TPRG1 family |
| CA9 protein network | https://string-db.org/network/9606.ENSP00000367608 | Carbonic anhydrase 9; Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specifi [...] |
| APRT protein network | https://string-db.org/network/9606.ENSP00000367615 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis |
| HSPA14 protein network | https://string-db.org/network/9606.ENSP00000367623 | Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC comple [...] |
| ARHGEF16 protein network | https://string-db.org/network/9606.ENSP00000367629 | Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migrat [...] |
| ANKEF1 protein network | https://string-db.org/network/9606.ENSP00000367631 | Ankyrin repeat and EF-hand domain containing 1 |
| ARHGEF39 protein network | https://string-db.org/network/9606.ENSP00000367638 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation |
| OR5D16 protein network | https://string-db.org/network/9606.ENSP00000367649 | Olfactory receptor 5D16; Odorant receptor; Olfactory receptors, family 5 |
| OR5L2 protein network | https://string-db.org/network/9606.ENSP00000367650 | Olfactory receptor 5L2; Odorant receptor; Olfactory receptors, family 5 |
| PKHD1L1 protein network | https://string-db.org/network/9606.ENSP00000367655 | Fibrocystin-L; PKHD1 like 1 |
| ACTRT2 protein network | https://string-db.org/network/9606.ENSP00000367658 | Actin related protein T2 |
| OR4A5 protein network | https://string-db.org/network/9606.ENSP00000367664 | Olfactory receptor 4A5; Odorant receptor; Olfactory receptors, family 4 |
| MMEL1 protein network | https://string-db.org/network/9606.ENSP00000367668 | Membrane metallo-endopeptidase-like 1; Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety [...] |
| PAK7 protein network | https://string-db.org/network/9606.ENSP00000367686 | Serine/threonine-protein kinase PAK 5; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferat [...] |
| LPAR6 protein network | https://string-db.org/network/9606.ENSP00000367691 | Lysophosphatidic acid receptor 6; Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and [...] |
| ATP6AP2 protein network | https://string-db.org/network/9606.ENSP00000367697 | Renin receptor; Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in [...] |
| BCOR protein network | https://string-db.org/network/9606.ENSP00000367705 | BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6 and MLLT3. This [...] |
| HES5 protein network | https://string-db.org/network/9606.ENSP00000367714 | Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator (By similarity); Bas [...] |
| DCDC2 protein network | https://string-db.org/network/9606.ENSP00000367715 | Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral [...] |
| NUP160 protein network | https://string-db.org/network/9606.ENSP00000367721 | Nuclear pore complex protein Nup160; Involved in poly(A)+ RNA transport; Nucleoporins |
| PANK4 protein network | https://string-db.org/network/9606.ENSP00000367727 | Pantothenate kinase 4; Plays a role in the physiological regulation of the intracellular CoA concentration |
| NRSN1 protein network | https://string-db.org/network/9606.ENSP00000367739 | Neurensin-1; May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension. May play a role in memory con [...] |
| TSPAN7 protein network | https://string-db.org/network/9606.ENSP00000367743 | Tetraspanin-7; May be involved in cell proliferation and cell motility; CD molecules |
| CLLU1 protein network | https://string-db.org/network/9606.ENSP00000367746 | Chronic lymphocytic leukemia up-regulated 1 |
| PLCH2 protein network | https://string-db.org/network/9606.ENSP00000367747 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activa [...] |
| CLLU1OS protein network | https://string-db.org/network/9606.ENSP00000367748 | Chronic lymphocytic leukemia up-regulated 1 opposite strand |
| CAMKMT protein network | https://string-db.org/network/9606.ENSP00000367755 | Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin; Seven-beta-strand methyltransferase motif containing |
| UNC13B protein network | https://string-db.org/network/9606.ENSP00000367756 | Protein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in syn [...] |
| PLCB4 protein network | https://string-db.org/network/9606.ENSP00000367762 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...] |
| RPGR protein network | https://string-db.org/network/9606.ENSP00000367766 | X-linked retinitis pigmentosa GTPase regulator; Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filamen [...] |
| SLC35B4 protein network | https://string-db.org/network/9606.ENSP00000367770 | UDP-xylose and UDP-N-acetylglucosamine transporter; Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into G [...] |
| LIG3 protein network | https://string-db.org/network/9606.ENSP00000367787 | DNA ligase 3; Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand- break repair and sister chromatid exchange following treatment [...] |
| MORN1 protein network | https://string-db.org/network/9606.ENSP00000367792 | MORN repeat containing 1 |
| SRPX protein network | https://string-db.org/network/9606.ENSP00000367794 | Sushi repeat-containing protein SRPX; May be involved in phagocytosis during disk shedding, cell adhesion to cells other than the pigment epithelium or signal transduction; Sushi domain containin [...] |
| SKI protein network | https://string-db.org/network/9606.ENSP00000367797 | Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling; B [...] |
| DNAAF1 protein network | https://string-db.org/network/9606.ENSP00000367815 | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms. Involved in regulation [...] |
| PODXL protein network | https://string-db.org/network/9606.ENSP00000367817 | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighb [...] |
| FAM214B protein network | https://string-db.org/network/9606.ENSP00000367823 | Protein FAM214B; Family with sequence similarity 214 member B; Belongs to the FAM214 family |
| ITM2B protein network | https://string-db.org/network/9606.ENSP00000367828 | Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils [...] |
| PRKCZ protein network | https://string-db.org/network/9606.ENSP00000367830 | Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (M [...] |
| CCL7 protein network | https://string-db.org/network/9606.ENSP00000367832 | C-C motif chemokine 7; Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This prote [...] |
| PRPF18 protein network | https://string-db.org/network/9606.ENSP00000367835 | Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing; Spliceosomal C complex |
| DYNLT3 protein network | https://string-db.org/network/9606.ENSP00000367841 | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to a [...] |
| GABRD protein network | https://string-db.org/network/9606.ENSP00000367848 | Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...] |
| CYBB protein network | https://string-db.org/network/9606.ENSP00000367851 | Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single e [...] |
| C11orf49 protein network | https://string-db.org/network/9606.ENSP00000367878 | UPF0705 protein C11orf49; Chromosome 11 open reading frame 49; Belongs to the UPF0705 family |
| XK protein network | https://string-db.org/network/9606.ENSP00000367879 | Membrane transport protein XK; May be involved in sodium-dependent transport of neutral amino acids or oligopeptides; Blood group antigens |
| PIGO protein network | https://string-db.org/network/9606.ENSP00000367880 | GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannos [...] |
| LANCL3 protein network | https://string-db.org/network/9606.ENSP00000367882 | LanC-like protein 3; LanC like 3 |
| LRP4 protein network | https://string-db.org/network/9606.ENSP00000367888 | Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a [...] |
| NADK protein network | https://string-db.org/network/9606.ENSP00000367890 | NAD kinase; Belongs to the NAD kinase family |
| LGALS7 protein network | https://string-db.org/network/9606.ENSP00000367891 | Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and [...] |
| SEPHS1 protein network | https://string-db.org/network/9606.ENSP00000367893 | Selenide, water dikinase 1; Synthesizes selenophosphate from selenide and ATP |
| FANCG protein network | https://string-db.org/network/9606.ENSP00000367910 | Fanconi anemia group G protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in [...] |
| SYCE1L protein network | https://string-db.org/network/9606.ENSP00000367911 | Synaptonemal complex central element protein 1-like; May be involved in meiosis |
| FAM47C protein network | https://string-db.org/network/9606.ENSP00000367913 | Putative protein FAM47C; Family with sequence similarity 47 member C; Belongs to the FAM47 family |
| SUCLA2 protein network | https://string-db.org/network/9606.ENSP00000367923 | Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synt [...] |
| CXorf30 protein network | https://string-db.org/network/9606.ENSP00000367926 | Cilia- and flagella-associated protein 47; Chromosome X open reading frame 30 |
| CHDC2 protein network | https://string-db.org/network/9606.ENSP00000367929 | Cilia- and flagella-associated protein 47; Calponin homology domain containing 2 |
| OXER1 protein network | https://string-db.org/network/9606.ENSP00000367930 | Oxoeicosanoid receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic a [...] |
| COX7A2L protein network | https://string-db.org/network/9606.ENSP00000367938 | Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitoch [...] |
| UQCRQ protein network | https://string-db.org/network/9606.ENSP00000367939 | Cytochrome b-c1 complex subunit 8; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory cha [...] |
| GDF9 protein network | https://string-db.org/network/9606.ENSP00000367942 | Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S [...] |
| SHROOM1 protein network | https://string-db.org/network/9606.ENSP00000367950 | Protein Shroom1; May be involved in the assembly of microtubule arrays during cell elongation |
| UCMA protein network | https://string-db.org/network/9606.ENSP00000367952 | Unique cartilage matrix-associated protein; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and a [...] |
| SOWAHA protein network | https://string-db.org/network/9606.ENSP00000367965 | Ankyrin repeat domain-containing protein SOWAHA; Sosondowah ankyrin repeat domain family member A; Belongs to the SOWAH family |
| ID4 protein network | https://string-db.org/network/9606.ENSP00000367972 | DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming he [...] |
| SEPT8 protein network | https://string-db.org/network/9606.ENSP00000367991 | Septin-8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion; Septins |
| ESD protein network | https://string-db.org/network/9606.ENSP00000367992 | S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde |
| TMEM240 protein network | https://string-db.org/network/9606.ENSP00000368007 | Transmembrane protein 240; Belongs to the TMEM240 family |
| ZFC3H1 protein network | https://string-db.org/network/9606.ENSP00000368017 | Zinc finger C3H1 domain-containing protein; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exos [...] |
| OPTN protein network | https://string-db.org/network/9606.ENSP00000368022 | Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi [...] |
| ATAD3A protein network | https://string-db.org/network/9606.ENSP00000368030 | ATPase family AAA domain-containing protein 3A; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important ro [...] |
| ATAD3C protein network | https://string-db.org/network/9606.ENSP00000368062 | ATPase family, AAA domain containing 3C; Belongs to the AAA ATPase family |
| HAO1 protein network | https://string-db.org/network/9606.ENSP00000368066 | Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmi [...] |
| CYP4V2 protein network | https://string-db.org/network/9606.ENSP00000368079 | Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the [...] |
| CDKL4 protein network | https://string-db.org/network/9606.ENSP00000368080 | Cyclin-dependent kinase-like 4; Cyclin dependent kinase like 4 |
| RAD50 protein network | https://string-db.org/network/9606.ENSP00000368100 | DNA repair protein RAD50; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The compl [...] |
| CCDC3 protein network | https://string-db.org/network/9606.ENSP00000368102 | Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha- induced NF-kappaB activation in E [...] |
| BMP2 protein network | https://string-db.org/network/9606.ENSP00000368104 | Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 st [...] |
| ACCSL protein network | https://string-db.org/network/9606.ENSP00000368109 | Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotra [...] |
| GALT protein network | https://string-db.org/network/9606.ENSP00000368119 | Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism |
| C4orf47 protein network | https://string-db.org/network/9606.ENSP00000368127 | UPF0602 protein C4orf47; Chromosome 4 open reading frame 47; Belongs to the UPF0602 family |
| LRRN4 protein network | https://string-db.org/network/9606.ENSP00000368135 | Leucine-rich repeat neuronal protein 4; May play an important role in hippocampus-dependent long-lasting memory; Fibronectin type III domain containing |
| CRLS1 protein network | https://string-db.org/network/9606.ENSP00000368140 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylg [...] |
| PRR5L protein network | https://string-db.org/network/9606.ENSP00000368144 | Proline-rich protein 5-like; Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 com [...] |
| ALKBH6 protein network | https://string-db.org/network/9606.ENSP00000368152 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron; Belongs to the alkB family |
| MCM8 protein network | https://string-db.org/network/9606.ENSP00000368164 | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The M [...] |
| SDHAF1 protein network | https://string-db.org/network/9606.ENSP00000368165 | Succinate dehydrogenase assembly factor 1, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...] |
| DVL1 protein network | https://string-db.org/network/9606.ENSP00000368169 | Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream [...] |
| DHRS13 protein network | https://string-db.org/network/9606.ENSP00000368173 | Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily |
| ARID3C protein network | https://string-db.org/network/9606.ENSP00000368189 | AT-rich interactive domain-containing protein 3C; AT-rich interaction domain containing |
| NPHS1 protein network | https://string-db.org/network/9606.ENSP00000368190 | Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the [...] |
| PGPEP1L protein network | https://string-db.org/network/9606.ENSP00000368199 | Pyroglutamyl-peptidase 1-like protein; Pyroglutamyl-peptidase I like |
| FTHL17 protein network | https://string-db.org/network/9606.ENSP00000368207 | Ferritin heavy chain like 17 |
| TAB3 protein network | https://string-db.org/network/9606.ENSP00000368215 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays [...] |
| ATL2 protein network | https://string-db.org/network/9606.ENSP00000368237 | Atlastin-2; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...] |
| CHGB protein network | https://string-db.org/network/9606.ENSP00000368244 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides |
| CXorf21 protein network | https://string-db.org/network/9606.ENSP00000368245 | Uncharacterized protein CXorf21; Chromosome X open reading frame 21 |
| NR0B1 protein network | https://string-db.org/network/9606.ENSP00000368253 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulat [...] |
| MAGEB1 protein network | https://string-db.org/network/9606.ENSP00000368264 | Melanoma-associated antigen B1; MAGE family member B1 |
| CNTFR protein network | https://string-db.org/network/9606.ENSP00000368265 | Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity; Belongs to the type I cytokine receptor family. Type 3 subfamily |
| MAGEB4 protein network | https://string-db.org/network/9606.ENSP00000368266 | Melanoma-associated antigen B4; MAGE family member B4 |
| MAGEB2 protein network | https://string-db.org/network/9606.ENSP00000368273 | Melanoma-associated antigen B2; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...] |
| IL1RAPL1 protein network | https://string-db.org/network/9606.ENSP00000368278 | Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate th [...] |
| C11orf91 protein network | https://string-db.org/network/9606.ENSP00000368296 | Uncharacterized protein C11orf91; Chromosome 11 open reading frame 91 |
| MAGEB10 protein network | https://string-db.org/network/9606.ENSP00000368304 | Melanoma-associated antigen B10; MAGE family member B10 |
| GPCPD1 protein network | https://string-db.org/network/9606.ENSP00000368305 | Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activit [...] |
| NRCAM protein network | https://string-db.org/network/9606.ENSP00000368314 | Neuronal cell adhesion molecule; Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth [...] |
| PUSL1 protein network | https://string-db.org/network/9606.ENSP00000368318 | Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family |
| MAGEB6 protein network | https://string-db.org/network/9606.ENSP00000368320 | Melanoma-associated antigen B6; MAGE family member B6 |
| ARX protein network | https://string-db.org/network/9606.ENSP00000368332 | Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the [...] |
| RBM24 protein network | https://string-db.org/network/9606.ENSP00000368341 | RNA-binding protein 24; Plays a role in myogenic differentiation by regulating MYOG levels. Binds to the 3'-UTR of MYOG mRNA and regulates its stability; RNA binding motif containing |
| POLA1 protein network | https://string-db.org/network/9606.ENSP00000368349 | DNA polymerase alpha catalytic subunit; Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalyt [...] |
| PRKD3 protein network | https://string-db.org/network/9606.ENSP00000368356 | Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similar [...] |
| FABP9 protein network | https://string-db.org/network/9606.ENSP00000368362 | Fatty acid binding protein family |
| NGRN protein network | https://string-db.org/network/9606.ENSP00000368389 | Neugrin; May be involved in neuronal differentiation |
| LYRM9 protein network | https://string-db.org/network/9606.ENSP00000368397 | LYR motif containing 9; Belongs to the complex I LYR family. LYRM9 subfamily |
| KCTD4 protein network | https://string-db.org/network/9606.ENSP00000368402 | BTB/POZ domain-containing protein KCTD4; Potassium channel tetramerization domain containing 4 |
| SCNN1D protein network | https://string-db.org/network/9606.ENSP00000368411 | Amiloride-sensitive sodium channel subunit delta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and [...] |
| BCAP29 protein network | https://string-db.org/network/9606.ENSP00000368414 | B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By s [...] |
| PCYT1B protein network | https://string-db.org/network/9606.ENSP00000368439 | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis |
| GPALPP1 protein network | https://string-db.org/network/9606.ENSP00000368447 | GPALPP motifs containing 1 |
| CD83 protein network | https://string-db.org/network/9606.ENSP00000368450 | CD83 antigen; May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation; CD molecules |
| NUDT2 protein network | https://string-db.org/network/9606.ENSP00000368455 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis; Belongs to the Nudix hydrolase family |
| PCNA protein network | https://string-db.org/network/9606.ENSP00000368458 | Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elo [...] |
| NUFIP1 protein network | https://string-db.org/network/9606.ENSP00000368459 | Nuclear fragile X mental retardation-interacting protein 1; Binds RNA |
| KIF24 protein network | https://string-db.org/network/9606.ENSP00000368464 | Kinesin-like protein KIF24; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading [...] |
| MCUR1 protein network | https://string-db.org/network/9606.ENSP00000368468 | Mitochondrial calcium uniporter regulator 1; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calciu [...] |
| ZFX protein network | https://string-db.org/network/9606.ENSP00000368475 | Zinc finger X-chromosomal protein; Probable transcriptional activator; Zinc fingers C2H2-type |
| SERP2 protein network | https://string-db.org/network/9606.ENSP00000368477 | Stress-associated endoplasmic reticulum protein 2; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against [...] |
| B3GALT6 protein network | https://string-db.org/network/9606.ENSP00000368496 | Beta-1,3-galactosyltransferase 6; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for gala [...] |
| C4orf46 protein network | https://string-db.org/network/9606.ENSP00000368503 | Renal cancer differentiation gene 1 protein; Chromosome 4 open reading frame 46 |
| CXorf58 protein network | https://string-db.org/network/9606.ENSP00000368511 | Putative uncharacterized protein CXorf58; Chromosome X open reading frame 58 |
| LGR4 protein network | https://string-db.org/network/9606.ENSP00000368516 | Leucine-rich repeat-containing G-protein coupled receptor 4; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon [...] |
| ECHDC3 protein network | https://string-db.org/network/9606.ENSP00000368517 | Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; enoyl-CoA hydratase domain containing 3; Belongs to the enoyl-CoA hydratase/isomerase family |
| DNAJC15 protein network | https://string-db.org/network/9606.ENSP00000368523 | DnaJ homolog subfamily C member 15; Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By sim [...] |
| APOO protein network | https://string-db.org/network/9606.ENSP00000368528 | MICOS complex subunit MIC26; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| TNFRSF4 protein network | https://string-db.org/network/9606.ENSP00000368538 | Tumor necrosis factor receptor superfamily member 4; Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity; CD molecules |
| UBAP2 protein network | https://string-db.org/network/9606.ENSP00000368540 | Ubiquitin associated protein 2 |
| VIT protein network | https://string-db.org/network/9606.ENSP00000368544 | Vitrin; Promotes matrix assembly and cell adhesiveness |
| FEZ2 protein network | https://string-db.org/network/9606.ENSP00000368547 | Fasciculation and elongation protein zeta-2; Involved in axonal outgrowth and fasciculation |
| DNAJC2 protein network | https://string-db.org/network/9606.ENSP00000368565 | DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-as [...] |
| ACSL6 protein network | https://string-db.org/network/9606.ENSP00000368566 | Long-chain-fatty-acid--CoA ligase 6; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metaboli [...] |
| SAT1 protein network | https://string-db.org/network/9606.ENSP00000368572 | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine > putrescine. This highly re [...] |
| GFOD1 protein network | https://string-db.org/network/9606.ENSP00000368589 | Belongs to the Gfo/Idh/MocA family |
| TTLL10 protein network | https://string-db.org/network/9606.ENSP00000368592 | Inactive polyglycylase TTLL10; Inactive polyglycylase; Tubulin tyrosine ligase family |
| ACOT9 protein network | https://string-db.org/network/9606.ENSP00000368605 | Acyl-coenzyme A thioesterase 9, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the [...] |
| VWA8 protein network | https://string-db.org/network/9606.ENSP00000368612 | Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro |
| GATA3 protein network | https://string-db.org/network/9606.ENSP00000368632 | Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AG [...] |
| SLC23A2 protein network | https://string-db.org/network/9606.ENSP00000368637 | Solute carrier family 23 member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate; Solute carriers |
| PRDX4 protein network | https://string-db.org/network/9606.ENSP00000368646 | Peroxiredoxin-4; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection agains [...] |
| SLC30A6 protein network | https://string-db.org/network/9606.ENSP00000368648 | Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment; Solute carriers |
| RGCC protein network | https://string-db.org/network/9606.ENSP00000368664 | Regulator of cell cycle RGCC; Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells [...] |
| PTCHD1 protein network | https://string-db.org/network/9606.ENSP00000368666 | Patched domain-containing protein 1; Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, g [...] |
| DDX53 protein network | https://string-db.org/network/9606.ENSP00000368667 | Probable ATP-dependent RNA helicase DDX53; DEAD-box helicase 53 |
| AGRN protein network | https://string-db.org/network/9606.ENSP00000368678 | Agrin; Agrin N-terminal 110 kDa subunit: is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate a [...] |
| PHEX protein network | https://string-db.org/network/9606.ENSP00000368682 | Phosphate-regulating neutral endopeptidase; Probably involved in bone and dentin mineralization and renal phosphate reabsorption; M13 metallopeptidases |
| EDN1 protein network | https://string-db.org/network/9606.ENSP00000368683 | Endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family |
| E2F4 protein network | https://string-db.org/network/9606.ENSP00000368686 | Transcription factor E2F4; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of ge [...] |
| LYRM7 protein network | https://string-db.org/network/9606.ENSP00000368688 | Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subuni [...] |
| HIVEP1 protein network | https://string-db.org/network/9606.ENSP00000368698 | Zinc finger protein 40; This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HI [...] |
| ISG15 protein network | https://string-db.org/network/9606.ENSP00000368699 | Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its [...] |
| RASSF2 protein network | https://string-db.org/network/9606.ENSP00000368710 | Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting [...] |
| NAA16 protein network | https://string-db.org/network/9606.ENSP00000368716 | N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity; Armadill [...] |
| PLEKHN1 protein network | https://string-db.org/network/9606.ENSP00000368720 | Controls the stability of the leptin mRNA harboring an AU- rich element (ARE) in its 3' UTR, in cooperation with the RNA stabilizer ELAVL1 . Decreases the stability of the leptin mRNA by antagoni [...] |
| XDH protein network | https://string-db.org/network/9606.ENSP00000368727 | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generat [...] |
| TMEM170B protein network | https://string-db.org/network/9606.ENSP00000368737 | Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which re [...] |
| PRNP protein network | https://string-db.org/network/9606.ENSP00000368752 | Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May pr [...] |
| CTXN3 protein network | https://string-db.org/network/9606.ENSP00000368758 | Cortexin-3; Cortexin 3; Belongs to the cortexin family |
| NEDD9 protein network | https://string-db.org/network/9606.ENSP00000368759 | Enhancer of filamentation 1; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control sign [...] |
| ZNF827 protein network | https://string-db.org/network/9606.ENSP00000368761 | Zinc finger protein 827; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ADRA1D protein network | https://string-db.org/network/9606.ENSP00000368766 | Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium; Adrenoceptors |
| ASPH protein network | https://string-db.org/network/9606.ENSP00000368767 | Aspartyl/asparaginyl beta-hydroxylase; Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins; Belongs to the asp [...] |
| MUC3A protein network | https://string-db.org/network/9606.ENSP00000368771 | Mucin-3A; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involve [...] |
| MTRF1 protein network | https://string-db.org/network/9606.ENSP00000368793 | Peptide chain release factor 1, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop [...] |
| KBTBD7 protein network | https://string-db.org/network/9606.ENSP00000368797 | Kelch repeat and BTB domain containing 7 |
| MBTPS2 protein network | https://string-db.org/network/9606.ENSP00000368798 | Membrane-bound transcription factor site-2 protease; Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the [...] |
| KBTBD6 protein network | https://string-db.org/network/9606.ENSP00000368799 | Kelch repeat and BTB domain containing 6 |
| WBP4 protein network | https://string-db.org/network/9606.ENSP00000368801 | WW domain-binding protein 4; Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex |
| GCM2 protein network | https://string-db.org/network/9606.ENSP00000368805 | Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, ma [...] |
| SMPX protein network | https://string-db.org/network/9606.ENSP00000368808 | Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Deafness associa [...] |
| KLHL34 protein network | https://string-db.org/network/9606.ENSP00000368813 | Kelch-like protein 34; Kelch like family member 34; BTB domain containing |
| CMTM1 protein network | https://string-db.org/network/9606.ENSP00000368814 | CKLF like MARVEL transmembrane domain containing 1 |
| TOM1L2 protein network | https://string-db.org/network/9606.ENSP00000368818 | TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling |
| CNKSR2 protein network | https://string-db.org/network/9606.ENSP00000368824 | Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family |
| SNX2 protein network | https://string-db.org/network/9606.ENSP00000368831 | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphospha [...] |
| YPEL5 protein network | https://string-db.org/network/9606.ENSP00000368835 | Protein yippee-like 5; Yippee like family; Belongs to the yippee family |
| NFX1 protein network | https://string-db.org/network/9606.ENSP00000368856 | Transcriptional repressor NF-X1; Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response b [...] |
| INSC protein network | https://string-db.org/network/9606.ENSP00000368872 | Protein inscuteable homolog; May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis. May regulate cell proliferation and di [...] |
| FAM179A protein network | https://string-db.org/network/9606.ENSP00000368876 | TOG array regulator of axonemal microtubules protein 2; Family with sequence similarity 179, member A |
| FOXO1 protein network | https://string-db.org/network/9606.ENSP00000368880 | Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response eleme [...] |
| KIN protein network | https://string-db.org/network/9606.ENSP00000368881 | DNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and re [...] |
| RPS6KA3 protein network | https://string-db.org/network/9606.ENSP00000368884 | Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the [...] |
| PAK1IP1 protein network | https://string-db.org/network/9606.ENSP00000368887 | P21-activated protein kinase-interacting protein 1; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation [...] |
| LHFP protein network | https://string-db.org/network/9606.ENSP00000368908 | LHFPL tetraspan subfamily member 6 protein; Lipoma HMGIC fusion partner |
| GCNT2 protein network | https://string-db.org/network/9606.ENSP00000368917 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during e [...] |
| NHLRC3 protein network | https://string-db.org/network/9606.ENSP00000368920 | NHL repeat containing 3 |
| TFAP2A protein network | https://string-db.org/network/9606.ENSP00000368924 | Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...] |
| EIF1AX protein network | https://string-db.org/network/9606.ENSP00000368927 | Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding [...] |
| CCDC112 protein network | https://string-db.org/network/9606.ENSP00000368931 | Coiled-coil domain containing 112 |
| STOML3 protein network | https://string-db.org/network/9606.ENSP00000368952 | Stomatin-like protein 3; Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 fun [...] |
| REEP5 protein network | https://string-db.org/network/9606.ENSP00000368959 | Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family |
| MAP7D2 protein network | https://string-db.org/network/9606.ENSP00000368964 | MAP7 domain containing 2 |
| HGSNAT protein network | https://string-db.org/network/9606.ENSP00000368965 | Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, con [...] |
| TRPC3 protein network | https://string-db.org/network/9606.ENSP00000368966 | Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...] |
| UFM1 protein network | https://string-db.org/network/9606.ENSP00000368970 | Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, [...] |
| KIFC3 protein network | https://string-db.org/network/9606.ENSP00000368976 | Kinesin-like protein KIFC3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance; Belongs to the TRAFAC [...] |
| SLC35B3 protein network | https://string-db.org/network/9606.ENSP00000368981 | Adenosine 3'-phospho 5'-phosphosulfate transporter 2; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sul [...] |
| KATNB1 protein network | https://string-db.org/network/9606.ENSP00000368982 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of [...] |
| EXOSC9 protein network | https://string-db.org/network/9606.ENSP00000368984 | Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| OR6C65 protein network | https://string-db.org/network/9606.ENSP00000368986 | Olfactory receptor 6C65; Odorant receptor; Olfactory receptors, family 6 |
| OR6C75 protein network | https://string-db.org/network/9606.ENSP00000368987 | Olfactory receptor 6C75; Odorant receptor; Olfactory receptors, family 6 |
| OR6C3 protein network | https://string-db.org/network/9606.ENSP00000368989 | Olfactory receptor 6C3; Odorant receptor; Olfactory receptors, family 6 |
| OR6C1 protein network | https://string-db.org/network/9606.ENSP00000368990 | Olfactory receptor 6C1; Odorant receptor; Olfactory receptors, family 6 |
| ARHGAP44 protein network | https://string-db.org/network/9606.ENSP00000368994 | Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-boun [...] |
| CXorf23 protein network | https://string-db.org/network/9606.ENSP00000369009 | BCLAF1 and THRAP3 family member 3; Chromosome X open reading frame 23; Belongs to the BCLAF1/THRAP3 family |
| NDNF protein network | https://string-db.org/network/9606.ENSP00000369014 | Protein NDNF; Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth. Promotes endothelial cell survival, vess [...] |
| INSL3 protein network | https://string-db.org/network/9606.ENSP00000369017 | Insulin-like 3; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor; Belongs to the insulin family |
| TRPC4 protein network | https://string-db.org/network/9606.ENSP00000369027 | Short transient receptor potential channel 4; Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Pro [...] |
| EEF1E1 protein network | https://string-db.org/network/9606.ENSP00000369038 | Eukaryotic translation elongation factor 1 epsilon-1; Positive modulator of ATM response to DNA damage |
| IPO7 protein network | https://string-db.org/network/9606.ENSP00000369042 | Importin-7; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Actin [...] |
| SPINK4 protein network | https://string-db.org/network/9606.ENSP00000369045 | Serine peptidase inhibitor, Kazal type 4 |
| CYP1A1 protein network | https://string-db.org/network/9606.ENSP00000369050 | Cytochrome P450 1A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| B4GALT1 protein network | https://string-db.org/network/9606.ENSP00000369055 | Beta-1,4-galactosyltransferase 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linke [...] |
| POSTN protein network | https://string-db.org/network/9606.ENSP00000369071 | Periostin; Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic acti [...] |
| CENPB protein network | https://string-db.org/network/9606.ENSP00000369075 | Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays [...] |
| SPEF1 protein network | https://string-db.org/network/9606.ENSP00000369080 | Sperm flagellar protein 1; Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and sta [...] |
| TXNDC5 protein network | https://string-db.org/network/9606.ENSP00000369081 | Thioredoxin domain-containing protein 5; Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By si [...] |
| ADPRM protein network | https://string-db.org/network/9606.ENSP00000369099 | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose [...] |
| CSNK1A1L protein network | https://string-db.org/network/9606.ENSP00000369126 | Casein kinase I isoform alpha-like; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large numbe [...] |
| DNAJA1 protein network | https://string-db.org/network/9606.ENSP00000369127 | DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Plays a role in protein transpo [...] |
| DSP protein network | https://string-db.org/network/9606.ENSP00000369129 | Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin- plakoglobin complexes into discrete plasma membrane domains and in the anc [...] |
| SIN3B protein network | https://string-db.org/network/9606.ENSP00000369131 | Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX he [...] |
| PDHA1 protein network | https://string-db.org/network/9606.ENSP00000369134 | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereb [...] |
| MT1M protein network | https://string-db.org/network/9606.ENSP00000369146 | Metallothionein-1M; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| SMAD9 protein network | https://string-db.org/network/9606.ENSP00000369154 | Mothers against decapentaplegic homolog 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD); Belongs to [...] |
| OR10A4 protein network | https://string-db.org/network/9606.ENSP00000369157 | Olfactory receptor 10A4; Odorant receptor (Potential). May be involved in taste perception; Olfactory receptors, family 10 |
| RIOK1 protein network | https://string-db.org/network/9606.ENSP00000369162 | Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre- rRNA to the mature 18S rRNA. Require [...] |
| NDUFB6 protein network | https://string-db.org/network/9606.ENSP00000369176 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| GPR64 protein network | https://string-db.org/network/9606.ENSP00000369198 | Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within [...] |
| SOHLH2 protein network | https://string-db.org/network/9606.ENSP00000369210 | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; Probable transcription factor, which may be involved in spermatogenesis and oogenesis; Basic helix-loop-helix [...] |
| DDX58 protein network | https://string-db.org/network/9606.ENSP00000369213 | Probable ATP-dependent RNA helicase DDX58; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation [...] |
| ARIH1 protein network | https://string-db.org/network/9606.ENSP00000369217 | E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin- conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubi [...] |
| ADAM32 protein network | https://string-db.org/network/9606.ENSP00000369238 | Disintegrin and metalloproteinase domain-containing protein 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein; ADAM metallopeptidase [...] |
| MAB21L1 protein network | https://string-db.org/network/9606.ENSP00000369251 | Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is uncle [...] |
| RPGRIP1L protein network | https://string-db.org/network/9606.ENSP00000369257 | Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, [...] |
| CNGA4 protein network | https://string-db.org/network/9606.ENSP00000369268 | Cyclic nucleotide-gated cation channel alpha-4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory [...] |
| RREB1 protein network | https://string-db.org/network/9606.ENSP00000369270 | Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differenti [...] |
| PHKA2 protein network | https://string-db.org/network/9606.ENSP00000369274 | Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bin [...] |
| LY86 protein network | https://string-db.org/network/9606.ENSP00000369286 | Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell su [...] |
| LETM2 protein network | https://string-db.org/network/9606.ENSP00000369291 | LETM1 domain-containing protein LETM2, mitochondrial; Leucine zipper and EF-hand containing transmembrane protein 2 |
| SAMD9 protein network | https://string-db.org/network/9606.ENSP00000369292 | Sterile alpha motif domain-containing protein 9; May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF [...] |
| IL2RA protein network | https://string-db.org/network/9606.ENSP00000369293 | Interleukin-2 receptor subunit alpha; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress [...] |
| TRIM22 protein network | https://string-db.org/network/9606.ENSP00000369299 | E3 ubiquitin-protein ligase TRIM22; Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of v [...] |
| GLRX protein network | https://string-db.org/network/9606.ENSP00000369314 | Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Glutaredoxin domain c [...] |
| KRT6A protein network | https://string-db.org/network/9606.ENSP00000369317 | Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a majo [...] |
| RHOBTB3 protein network | https://string-db.org/network/9606.ENSP00000369318 | Rho-related BTB domain-containing protein 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating [...] |
| RS1 protein network | https://string-db.org/network/9606.ENSP00000369320 | Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homom [...] |
| CDKL5 protein network | https://string-db.org/network/9606.ENSP00000369325 | Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2; Cilia and flagella associated |
| LINGO2 protein network | https://string-db.org/network/9606.ENSP00000369328 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2; Leucine rich repeat and Ig domain containing 2 |
| FBXO18 protein network | https://string-db.org/network/9606.ENSP00000369335 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks. [...] |
| GPR150 protein network | https://string-db.org/network/9606.ENSP00000369344 | Probable G-protein coupled receptor 150; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ARSK protein network | https://string-db.org/network/9606.ENSP00000369346 | Arylsulfatase family member K; Sulfatases |
| KRT81 protein network | https://string-db.org/network/9606.ENSP00000369349 | Keratin, type II cuticular Hb1; Keratins, type II |
| EQTN protein network | https://string-db.org/network/9606.ENSP00000369371 | Equatorin; Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis |
| BEND2 protein network | https://string-db.org/network/9606.ENSP00000369372 | BEN domain containing 2 |
| TRIM5 protein network | https://string-db.org/network/9606.ENSP00000369373 | Tripartite motif-containing protein 5; Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral [...] |
| TEK protein network | https://string-db.org/network/9606.ENSP00000369375 | Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, [...] |
| SCML1 protein network | https://string-db.org/network/9606.ENSP00000369380 | Sex comb on midleg-like protein 1; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state [...] |
| MPV17 protein network | https://string-db.org/network/9606.ENSP00000369383 | Protein Mpv17; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenanc [...] |
| CDK14 protein network | https://string-db.org/network/9606.ENSP00000369390 | Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regula [...] |
| RPP40 protein network | https://string-db.org/network/9606.ENSP00000369391 | Ribonuclease P protein subunit p40; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends |
| LRRC19 protein network | https://string-db.org/network/9606.ENSP00000369395 | Leucine-rich repeat-containing protein 19; Leucine rich repeat containing 19 |
| SLC4A11 protein network | https://string-db.org/network/9606.ENSP00000369399 | Sodium bicarbonate transporter-like protein 11; Transporter which plays an important role in sodium- mediated fluid transport in different organs. Prevents severe morphological changes of the cor [...] |
| NHS protein network | https://string-db.org/network/9606.ENSP00000369400 | Nance-Horan syndrome protein; May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, [...] |
| SLC25A35 protein network | https://string-db.org/network/9606.ENSP00000369407 | Solute carrier family 25 member 35; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| EXOC3L4 protein network | https://string-db.org/network/9606.ENSP00000369409 | Exocyst complex component 3 like 4; Belongs to the SEC6 family |
| RFC3 protein network | https://string-db.org/network/9606.ENSP00000369411 | Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...] |
| STEAP4 protein network | https://string-db.org/network/9606.ENSP00000369419 | Metalloreductase STEAP4; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+) (By similarity). Uses NADP(+) as acceptor (By similarity). Plays a role in syst [...] |
| RBBP7 protein network | https://string-db.org/network/9606.ENSP00000369424 | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a mann [...] |
| CAAP1 protein network | https://string-db.org/network/9606.ENSP00000369431 | Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop |
| ANKRD16 protein network | https://string-db.org/network/9606.ENSP00000369436 | Ankyrin repeat domain-containing protein 16; Ankyrin repeat domain containing |
| KRTAP10-10 protein network | https://string-db.org/network/9606.ENSP00000369438 | Keratin-associated protein 10-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| TRIM6 protein network | https://string-db.org/network/9606.ENSP00000369440 | Tripartite motif-containing protein 6; E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells [...] |
| KL protein network | https://string-db.org/network/9606.ENSP00000369442 | Klotho; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glyco [...] |
| ITPA protein network | https://string-db.org/network/9606.ENSP00000369456 | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hyd [...] |
| ECI2 protein network | https://string-db.org/network/9606.ENSP00000369461 | Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (B [...] |
| TXLNG protein network | https://string-db.org/network/9606.ENSP00000369465 | Gamma-taxilin; May be involved in intracellular vesicle traffic. Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involv [...] |
| N4BP2L1 protein network | https://string-db.org/network/9606.ENSP00000369473 | NEDD4 binding protein 2 like 1 |
| BRCA2 protein network | https://string-db.org/network/9606.ENSP00000369497 | Breast cancer type 2 susceptibility protein; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly o [...] |
| SYAP1 protein network | https://string-db.org/network/9606.ENSP00000369500 | Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation |
| ATP6AP1L protein network | https://string-db.org/network/9606.ENSP00000369513 | V-type proton ATPase subunit S1-like protein; ATPase H+ transporting accessory protein 1 like |
| MTAP protein network | https://string-db.org/network/9606.ENSP00000369519 | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of M [...] |
| ALOX15B protein network | https://string-db.org/network/9606.ENSP00000369530 | Arachidonate 15-lipoxygenase B; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bi [...] |
| UBQLNL protein network | https://string-db.org/network/9606.ENSP00000369531 | Ubiquilin-like protein; Ubiquilin family |
| GDI2 protein network | https://string-db.org/network/9606.ENSP00000369538 | Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them |
| NABP2 protein network | https://string-db.org/network/9606.ENSP00000369545 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as [...] |
| S100G protein network | https://string-db.org/network/9606.ENSP00000369547 | S100 calcium binding protein G; Belongs to the S-100 family |
| IFNA8 protein network | https://string-db.org/network/9606.ENSP00000369553 | Interferon alpha-8; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfero [...] |
| IFNA2 protein network | https://string-db.org/network/9606.ENSP00000369554 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons |
| IFNA6 protein network | https://string-db.org/network/9606.ENSP00000369558 | Interferon alpha-6; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfero [...] |
| OR51I1 protein network | https://string-db.org/network/9606.ENSP00000369559 | Olfactory receptor 51I1; Odorant receptor; Olfactory receptors, family 51 |
| IFNA16 protein network | https://string-db.org/network/9606.ENSP00000369564 | Interferon alpha-16; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfer [...] |
| IFNA10 protein network | https://string-db.org/network/9606.ENSP00000369566 | Interferon alpha-10; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfer [...] |
| OR51B6 protein network | https://string-db.org/network/9606.ENSP00000369568 | Olfactory receptor 51B6; Odorant receptor; Olfactory receptors, family 51 |
| IFNA14 protein network | https://string-db.org/network/9606.ENSP00000369571 | Interferon alpha-14; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfer [...] |
| OR51B4 protein network | https://string-db.org/network/9606.ENSP00000369573 | Olfactory receptor 51B4; Odorant receptor; Olfactory receptors, family 51 |
| IFNA21 protein network | https://string-db.org/network/9606.ENSP00000369574 | Interferon alpha-21; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfer [...] |
| IFNW1 protein network | https://string-db.org/network/9606.ENSP00000369578 | Interferon omega 1; Interferons |
| IFNB1 protein network | https://string-db.org/network/9606.ENSP00000369581 | Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family |
| HBE1 protein network | https://string-db.org/network/9606.ENSP00000369586 | Hemoglobin subunit epsilon; The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin; Belongs to the globin family |
| CCDC85C protein network | https://string-db.org/network/9606.ENSP00000369592 | Coiled-coil domain-containing protein 85C; May play an important role in cortical development, especially in the maintenance of radial glia |
| FOCAD protein network | https://string-db.org/network/9606.ENSP00000369599 | Focadhesin; Potential tumor suppressor in gliomas; Armadillo-like helical domain containing |
| FBXO16 protein network | https://string-db.org/network/9606.ENSP00000369604 | F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation; F-boxes other |
| HBG2 protein network | https://string-db.org/network/9606.ENSP00000369609 | Hemoglobin subunit gamma-2; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains; Belongs to the globin family |
| SPZ1 protein network | https://string-db.org/network/9606.ENSP00000369611 | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell prolifer [...] |
| CNTROB protein network | https://string-db.org/network/9606.ENSP00000369614 | Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis |
| FASTKD5 protein network | https://string-db.org/network/9606.ENSP00000369618 | FAST kinase domain-containing protein 5, mitochondrial; Plays an important role in the processing of non- canonical mitochondrial mRNA precursors; FASTK mitochondrial RNA binding family |
| FAM50B protein network | https://string-db.org/network/9606.ENSP00000369627 | Protein FAM50B; Family with sequence similarity 50 member B |
| PXDC1 protein network | https://string-db.org/network/9606.ENSP00000369636 | PX domain containing 1 |
| GRPR protein network | https://string-db.org/network/9606.ENSP00000369643 | Gastrin-releasing peptide receptor; Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, res [...] |
| AVP protein network | https://string-db.org/network/9606.ENSP00000369647 | Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Endogenous ligands |
| HBD protein network | https://string-db.org/network/9606.ENSP00000369654 | Hemoglobin subunit delta; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family |
| FBXL19 protein network | https://string-db.org/network/9606.ENSP00000369666 | F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| BCL7C protein network | https://string-db.org/network/9606.ENSP00000369674 | B-cell CLL/lymphoma 7 protein family member C; May play an anti-apoptotic role; BAF complex |
| EMILIN1 protein network | https://string-db.org/network/9606.ENSP00000369677 | EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vesse [...] |
| USP3 protein network | https://string-db.org/network/9606.ENSP00000369681 | Ubiquitin carboxyl-terminal hydrolase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subseque [...] |
| MRPS26 protein network | https://string-db.org/network/9606.ENSP00000369682 | Mitochondrial ribosomal protein S26; Belongs to the mitochondrion-specific ribosomal protein mS26 family |
| CALML5 protein network | https://string-db.org/network/9606.ENSP00000369689 | Calmodulin-like protein 5; Binds calcium. May be involved in terminal differentiation of keratinocytes; EF-hand domain containing |
| MLLT3 protein network | https://string-db.org/network/9606.ENSP00000369695 | Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausi [...] |
| TMEM27 protein network | https://string-db.org/network/9606.ENSP00000369699 | Collectrin; Regulator of SNARE complex function. Stimulator of beta cell replication; Belongs to the TMEM27 family |
| LHFPL2 protein network | https://string-db.org/network/9606.ENSP00000369702 | LHFPL tetraspan subfamily member 2 protein; Plays a role in female and male fertility. Involved in distal reproductive tract development; LHFPL tetraspan proteins |
| TUBB2A protein network | https://string-db.org/network/9606.ENSP00000369703 | Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha c [...] |
| CHD3 protein network | https://string-db.org/network/9606.ENSP00000369716 | Chromodomain-helicase-DNA-binding protein 3; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring [...] |
| OR52A1 protein network | https://string-db.org/network/9606.ENSP00000369725 | Olfactory receptor 52A1; Odorant receptor; Olfactory receptors, family 52 |
| OR52J3 protein network | https://string-db.org/network/9606.ENSP00000369728 | Olfactory receptor 52J3; Odorant receptor; Olfactory receptors, family 52 |
| OR51A2 protein network | https://string-db.org/network/9606.ENSP00000369729 | Olfactory receptor 51A2; Odorant receptor; Olfactory receptors, family 51 |
| OR51A4 protein network | https://string-db.org/network/9606.ENSP00000369731 | Olfactory receptor 51A4; Odorant receptor; Olfactory receptors, family 51 |
| OR51T1 protein network | https://string-db.org/network/9606.ENSP00000369738 | Olfactory receptor 51T1; Odorant receptor; Olfactory receptors, family 51 |
| BPHL protein network | https://string-db.org/network/9606.ENSP00000369739 | Valacyclovir hydrolase; Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovi [...] |
| MMP26 protein network | https://string-db.org/network/9606.ENSP00000369753 | Matrix metalloproteinase-26; May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B; Belon [...] |
| C2CD4B protein network | https://string-db.org/network/9606.ENSP00000369755 | C2 calcium-dependent domain-containing protein 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion; Belongs to the C2CD4 family |
| PTPRA protein network | https://string-db.org/network/9606.ENSP00000369756 | Receptor-type tyrosine-protein phosphatase alpha; Protein tyrosine phosphatase, receptor type A; Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily |
| RPS6 protein network | https://string-db.org/network/9606.ENSP00000369757 | 40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA; S ribosomal proteins |
| ZNF763 protein network | https://string-db.org/network/9606.ENSP00000369774 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF768 protein network | https://string-db.org/network/9606.ENSP00000369777 | Zinc finger protein 768; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TUBAL3 protein network | https://string-db.org/network/9606.ENSP00000369784 | Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the al [...] |
| PIR protein network | https://string-db.org/network/9606.ENSP00000369786 | Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox-state-dependent manner. May be required for efficient terminal [...] |
| UCN3 protein network | https://string-db.org/network/9606.ENSP00000369798 | Urocortin-3; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress |
| VPS16 protein network | https://string-db.org/network/9606.ENSP00000369810 | Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...] |
| AKR1C4 protein network | https://string-db.org/network/9606.ENSP00000369814 | Aldo-keto reductase family 1 member C4; Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha- androstan-3-alpha,17-beta-diol (3-alpha-d [...] |
| SHBG protein network | https://string-db.org/network/9606.ENSP00000369816 | Sex hormone-binding globulin; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-d [...] |
| PIGA protein network | https://string-db.org/network/9606.ENSP00000369820 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit A; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis; [...] |
| NQO2 protein network | https://string-db.org/network/9606.ENSP00000369822 | Ribosyldihydronicotinamide dehydrogenase [quinone]; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathwa [...] |
| TEX26 protein network | https://string-db.org/network/9606.ENSP00000369840 | Testis-expressed protein 26; Testis expressed 26 |
| MEDAG protein network | https://string-db.org/network/9606.ENSP00000369849 | Mesenteric estrogen-dependent adipogenesis protein; Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes |
| C2CD2 protein network | https://string-db.org/network/9606.ENSP00000369853 | C2 calcium dependent domain containing 2 |
| ASB9 protein network | https://string-db.org/network/9606.ENSP00000369855 | Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination an [...] |
| FAM175A protein network | https://string-db.org/network/9606.ENSP00000369857 | BRCA1-A complex subunit Abraxas 1; Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the [...] |
| MOSPD2 protein network | https://string-db.org/network/9606.ENSP00000369860 | Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines |
| COL4A3BP protein network | https://string-db.org/network/9606.ENSP00000369862 | Collagen type IV alpha-3-binding protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in [...] |
| FAM57B protein network | https://string-db.org/network/9606.ENSP00000369863 | Protein FAM57B; Involved in ceramide synthesis; TLC domain containing |
| HAUS6 protein network | https://string-db.org/network/9606.ENSP00000369871 | HAUS augmin-like complex subunit 6; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes th [...] |
| SLTM protein network | https://string-db.org/network/9606.ENSP00000369887 | SAFB-like transcription modulator; When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis; RNA binding motif containing |
| COL2A1 protein network | https://string-db.org/network/9606.ENSP00000369889 | Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of [...] |
| GEMIN8 protein network | https://string-db.org/network/9606.ENSP00000369895 | Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important r [...] |
| CARS protein network | https://string-db.org/network/9606.ENSP00000369897 | Cysteine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class I; Belongs to the class-I aminoacyl-tRNA synthetase family |
| RRAGA protein network | https://string-db.org/network/9606.ENSP00000369899 | Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling casc [...] |
| FAM154A protein network | https://string-db.org/network/9606.ENSP00000369907 | Stabilizer of axonemal microtubules 1; May play a role in the regulation of cilium length. Stabilizes microtubules at low temperature; Belongs to the FAM154 family |
| NAP1L4 protein network | https://string-db.org/network/9606.ENSP00000369915 | Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly; Belongs to the nucleosome assembly protein (NAP) family |
| ADAMTSL1 protein network | https://string-db.org/network/9606.ENSP00000369921 | ADAMTS-like protein 1; I-set domain containing; ADAMTS like |
| AKR1C3 protein network | https://string-db.org/network/9606.ENSP00000369927 | Aldo-keto reductase family 1 member C3; Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the [...] |
| SLC22A18 protein network | https://string-db.org/network/9606.ENSP00000369948 | Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related [...] |
| TMEM239 protein network | https://string-db.org/network/9606.ENSP00000369959 | Transmembrane protein 239 |
| ADRA1A protein network | https://string-db.org/network/9606.ENSP00000369960 | Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect i [...] |
| IGSF5 protein network | https://string-db.org/network/9606.ENSP00000369962 | Immunoglobulin superfamily member 5; Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithel [...] |
| BTF3 protein network | https://string-db.org/network/9606.ENSP00000369965 | Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they [...] |
| EGFL6 protein network | https://string-db.org/network/9606.ENSP00000369976 | Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity); Belongs to the nephronectin fami [...] |
| CPXM1 protein network | https://string-db.org/network/9606.ENSP00000369979 | Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity); M14 carboxypeptidases |
| SH3GL2 protein network | https://string-db.org/network/9606.ENSP00000369981 | Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to m [...] |
| KATNAL1 protein network | https://string-db.org/network/9606.ENSP00000369989 | Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-d [...] |
| ATXN3L protein network | https://string-db.org/network/9606.ENSP00000369996 | Ataxin-3-like protein; Deubiquitinating enzyme that cleaves both 'Lys-48'- linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro); MJD deubiquinating enzymes |
| BNIP3L protein network | https://string-db.org/network/9606.ENSP00000370003 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, althoug [...] |
| TMSB4X protein network | https://string-db.org/network/9606.ENSP00000370010 | Thymosin beta-4; Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization |
| PTCD2 protein network | https://string-db.org/network/9606.ENSP00000370013 | Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function |
| CNTLN protein network | https://string-db.org/network/9606.ENSP00000370021 | Centlein; Required for centrosome cohesion and recruitment of CEP68 to centrosomes |
| EBF4 protein network | https://string-db.org/network/9606.ENSP00000370022 | Transcription factor COE4; Transcriptional factor which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'; Belongs to the COE family |
| HADHA protein network | https://string-db.org/network/9606.ENSP00000370023 | Trifunctional enzyme subunit alpha, mitochondrial; Bifunctional subunit; In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family |
| TLR7 protein network | https://string-db.org/network/9606.ENSP00000370034 | Toll-like receptor 7; Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific t [...] |
| BNC2 protein network | https://string-db.org/network/9606.ENSP00000370047 | Zinc finger protein basonuclin-2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes; Zinc fingers C2H2-type |
| UBL3 protein network | https://string-db.org/network/9606.ENSP00000370055 | Ubiquitin-like protein 3; Ubiquitin like 3 |
| FRMPD4 protein network | https://string-db.org/network/9606.ENSP00000370057 | FERM and PDZ domain-containing protein 4; Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinos [...] |
| C9orf92 protein network | https://string-db.org/network/9606.ENSP00000370058 | Putative uncharacterized protein C9orf92; Chromosome 9 open reading frame 92 |
| SERPINB9 protein network | https://string-db.org/network/9606.ENSP00000370074 | Serpin B9; Granzyme B inhibitor; Serpin peptidase inhibitors |
| CCDC171 protein network | https://string-db.org/network/9606.ENSP00000370077 | Coiled-coil domain containing 171 |
| PDE4A protein network | https://string-db.org/network/9606.ENSP00000370078 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phospho [...] |
| SMN1 protein network | https://string-db.org/network/9606.ENSP00000370083 | Survival of motor neuron 1, telomeric; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays a [...] |
| AMELX protein network | https://string-db.org/network/9606.ENSP00000370088 | Amelogenin, X isoform; Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in t [...] |
| GPS2 protein network | https://string-db.org/network/9606.ENSP00000370104 | G protein pathway suppressor 2; Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. May act as a regulator of adipogenisis (By similarity) |
| PSIP1 protein network | https://string-db.org/network/9606.ENSP00000370109 | PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulati [...] |
| SERPINB1 protein network | https://string-db.org/network/9606.ENSP00000370115 | Leukocyte elastase inhibitor; Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also functions as a potent intracell [...] |
| SMN2 protein network | https://string-db.org/network/9606.ENSP00000370119 | Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an import [...] |
| HMGN1 protein network | https://string-db.org/network/9606.ENSP00000370125 | Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which [...] |
| SERF1B protein network | https://string-db.org/network/9606.ENSP00000370126 | Small EDRK-rich factor 1B; Belongs to the SERF family |
| SLC7A1 protein network | https://string-db.org/network/9606.ENSP00000370128 | High affinity cationic amino acid transporter 1; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues [...] |
| AKR1C2 protein network | https://string-db.org/network/9606.ENSP00000370129 | Aldo-keto reductase family 1 member C2; Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Cat [...] |
| WRNIP1 protein network | https://string-db.org/network/9606.ENSP00000370150 | ATPase WRNIP1; Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediat [...] |
| SLC46A3 protein network | https://string-db.org/network/9606.ENSP00000370192 | Solute carrier family 46 member 3; Belongs to the major facilitator superfamily. SLC46A family |
| AK6 protein network | https://string-db.org/network/9606.ENSP00000370193 | Transcription initiation factor TFIID subunit 9; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside [...] |
| GMDS protein network | https://string-db.org/network/9606.ENSP00000370194 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydrata [...] |
| SBF1 protein network | https://string-db.org/network/9606.ENSP00000370196 | Myotubularin-related protein 5; Probable pseudophosphatase. Lacks several amino acids in the catalytic pocket which renders it catalytically inactive as a phosphatase. The pocket is however suffi [...] |
| SNAPC3 protein network | https://string-db.org/network/9606.ENSP00000370200 | snRNA-activating protein complex subunit 3; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence elem [...] |
| TAF9 protein network | https://string-db.org/network/9606.ENSP00000370201 | Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP ar [...] |
| RABGEF1 protein network | https://string-db.org/network/9606.ENSP00000370208 | RAB guanine nucleotide exchange factor 1; VPS9 domain containing |
| CLCN4 protein network | https://string-db.org/network/9606.ENSP00000370213 | H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons; Belongs to the chloride channel (TC 2.A.49) famil [...] |
| CENPO protein network | https://string-db.org/network/9606.ENSP00000370214 | Centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...] |
| NOXRED1 protein network | https://string-db.org/network/9606.ENSP00000370215 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase |
| POMP protein network | https://string-db.org/network/9606.ENSP00000370222 | Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the assoc [...] |
| IDH3B protein network | https://string-db.org/network/9606.ENSP00000370223 | Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Plays a structural role to facilitate the assembly and ensure the full activity of the enzyme catalyzing the decarboxylation of isocitr [...] |
| PARM1 protein network | https://string-db.org/network/9606.ENSP00000370224 | Prostate androgen-regulated mucin-like protein 1; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis |
| WWC3 protein network | https://string-db.org/network/9606.ENSP00000370242 | Protein WWC3; WWC family member 3 |
| NKX3-1 protein network | https://string-db.org/network/9606.ENSP00000370253 | Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal [...] |
| AKR1C1 protein network | https://string-db.org/network/9606.ENSP00000370254 | Aldo-keto reductase family 1 member C1; Converts progesterone to its inactive form, 20-alpha- dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of [...] |
| FOXC1 protein network | https://string-db.org/network/9606.ENSP00000370256 | Forkhead box protein C1; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin developm [...] |
| EIF3CL protein network | https://string-db.org/network/9606.ENSP00000370258 | Eukaryotic translation initiation factor 3 subunit C-like protein; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiati [...] |
| SELO protein network | https://string-db.org/network/9606.ENSP00000370288 | Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation) . May be a redox-active mitochondrial selenoprotein which interacts with a [...] |
| HUS1B protein network | https://string-db.org/network/9606.ENSP00000370293 | Checkpoint protein HUS1B; HUS1 checkpoint clamp component B; Belongs to the HUS1 family |
| CER1 protein network | https://string-db.org/network/9606.ENSP00000370297 | Cerberus; Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gast [...] |
| SHROOM2 protein network | https://string-db.org/network/9606.ENSP00000370299 | Protein Shroom2; May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their asso [...] |
| ZDHHC21 protein network | https://string-db.org/network/9606.ENSP00000370303 | Palmitoyltransferase ZDHHC21; Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular [...] |
| CEP152 protein network | https://string-db.org/network/9606.ENSP00000370337 | Centrosomal protein of 152 kDa; Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recr [...] |
| NFIB protein network | https://string-db.org/network/9606.ENSP00000370340 | Nuclear factor 1 B-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...] |
| IRF4 protein network | https://string-db.org/network/9606.ENSP00000370343 | Interferon regulatory factor 4; Transcriptional activator. Binds to the interferon- stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enh [...] |
| PAN3 protein network | https://string-db.org/network/9606.ENSP00000370345 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediat [...] |
| NLN protein network | https://string-db.org/network/9606.ENSP00000370372 | Neurolysin, mitochondrial; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A; Belongs to the peptidase M3 family |
| FKBP1B protein network | https://string-db.org/network/9606.ENSP00000370373 | Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catal [...] |
| DUT protein network | https://string-db.org/network/9606.ENSP00000370376 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decrea [...] |
| PITRM1 protein network | https://string-db.org/network/9606.ENSP00000370377 | Presequence protease, mitochondrial; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides i [...] |
| RUFY3 protein network | https://string-db.org/network/9606.ENSP00000370394 | Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). M [...] |
| SGTB protein network | https://string-db.org/network/9606.ENSP00000370395 | Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Tetratricopeptide repeat domain con [...] |
| CDX2 protein network | https://string-db.org/network/9606.ENSP00000370408 | Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to ma [...] |
| ATP5EP2 protein network | https://string-db.org/network/9606.ENSP00000370414 | ATP synthase subunit epsilon-like protein, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient acros [...] |
| TTC38 protein network | https://string-db.org/network/9606.ENSP00000370419 | Tetratricopeptide repeat domain containing; Belongs to the TTC38 family |
| VCX3B protein network | https://string-db.org/network/9606.ENSP00000370420 | Variable charge X-linked protein 3B; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family |
| PDX1 protein network | https://string-db.org/network/9606.ENSP00000370421 | Pancreas/duodenum homeobox protein 1; Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-d [...] |
| PNPLA4 protein network | https://string-db.org/network/9606.ENSP00000370430 | Patatin-like phospholipase domain-containing protein 4; Lipid hydrolase; Patatin like phospholipase domain containing |
| ADAMTS6 protein network | https://string-db.org/network/9606.ENSP00000370443 | ADAM metallopeptidase with thrombospondin type 1 motif 6 |
| VCX protein network | https://string-db.org/network/9606.ENSP00000370447 | Variable charge X-linked protein 1; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family |
| CWC27 protein network | https://string-db.org/network/9606.ENSP00000370460 | Peptidyl-prolyl cis-trans isomerase CWC27 homolog; PPIases accelerate the folding of proteins; Belongs to the cyclophilin-type PPIase family |
| IGFBP3 protein network | https://string-db.org/network/9606.ENSP00000370473 | Insulin-like growth factor-binding protein 3; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on [...] |
| VCX3A protein network | https://string-db.org/network/9606.ENSP00000370479 | Variable charge X-linked protein 3; May mediate a process in spermatogenesis or may play a role in sex ratio distortion; Variable charge X/Y family |
| NLGN4X protein network | https://string-db.org/network/9606.ENSP00000370485 | Neuroligin-4, X-linked; Putative neuronal cell surface protein involved in cell- cell-interactions; Belongs to the type-B carboxylesterase/lipase family |
| CCM2 protein network | https://string-db.org/network/9606.ENSP00000370503 | Cerebral cavernous malformations 2 protein; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of e [...] |
| MTIF3 protein network | https://string-db.org/network/9606.ENSP00000370508 | Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subu [...] |
| PFKP protein network | https://string-db.org/network/9606.ENSP00000370517 | ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs t [...] |
| ARSF protein network | https://string-db.org/network/9606.ENSP00000370519 | Arylsulfatase F; Sulfatases |
| AIPL1 protein network | https://string-db.org/network/9606.ENSP00000370521 | Aryl-hydrocarbon-interacting protein-like 1; May be important in protein trafficking and/or protein folding and stabilization; FKBP prolyl isomerases |
| ARSH protein network | https://string-db.org/network/9606.ENSP00000370522 | Arylsulfatase family member H; Sulfatases |
| RCAN1 protein network | https://string-db.org/network/9606.ENSP00000370527 | Calcipressin-1; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs [...] |
| ACOT6 protein network | https://string-db.org/network/9606.ENSP00000370531 | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of [...] |
| GTF3A protein network | https://string-db.org/network/9606.ENSP00000370532 | Transcription factor IIIA; Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their [...] |
| SDC1 protein network | https://string-db.org/network/9606.ENSP00000370542 | Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert w [...] |
| SLC5A3 protein network | https://string-db.org/network/9606.ENSP00000370543 | Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function; Solute carriers |
| ARSD protein network | https://string-db.org/network/9606.ENSP00000370546 | Arylsulfatase D; Sulfatases |
| GYG2 protein network | https://string-db.org/network/9606.ENSP00000370555 | Glycogenin-2; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase; Glycosyltransferase family 8 |
| KIAA1644 protein network | https://string-db.org/network/9606.ENSP00000370568 | Uncharacterized protein KIAA1644; KIAA1644 |
| TH protein network | https://string-db.org/network/9606.ENSP00000370571 | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family |
| CD99 protein network | https://string-db.org/network/9606.ENSP00000370588 | CD99 antigen; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome t [...] |
| NOP56 protein network | https://string-db.org/network/9606.ENSP00000370589 | Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the [...] |
| PTPRD protein network | https://string-db.org/network/9606.ENSP00000370593 | Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically [...] |
| MIER3 protein network | https://string-db.org/network/9606.ENSP00000370596 | Mesoderm induction early response protein 3; Transcriptional repressor; Myb/SANT domain containing |
| TECRL protein network | https://string-db.org/network/9606.ENSP00000370607 | trans-2,3-enoyl-CoA reductase like |
| ZBED1 protein network | https://string-db.org/network/9606.ENSP00000370621 | Zinc finger BED domain-containing protein 1; Binds to 5'-TGTCG[CT]GA[CT]A-3' DNA elements found in the promoter regions of a number of genes related to cell proliferation. Binds to the histone H1 [...] |
| POLR2B protein network | https://string-db.org/network/9606.ENSP00000370625 | DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest com [...] |
| ASMT protein network | https://string-db.org/network/9606.ENSP00000370639 | Acetylserotonin O-methyltransferase; Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack e [...] |
| RDH14 protein network | https://string-db.org/network/9606.ENSP00000370648 | Retinol dehydrogenase 14; Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-tran [...] |
| SLC8A3 protein network | https://string-db.org/network/9606.ENSP00000370669 | Sodium/calcium exchanger 3; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca [...] |
| KLHL42 protein network | https://string-db.org/network/9606.ENSP00000370671 | Kelch-like protein 42; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligas [...] |
| MANSC4 protein network | https://string-db.org/network/9606.ENSP00000370673 | MANSC domain containing 4 |
| EXOC1 protein network | https://string-db.org/network/9606.ENSP00000370695 | Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane |
| P2RY8 protein network | https://string-db.org/network/9606.ENSP00000370697 | P2Y purinoceptor 8; Probable receptor for purines coupled to G-proteins; G protein-coupled receptors, Class A orphans |
| IL6ST protein network | https://string-db.org/network/9606.ENSP00000370698 | Interleukin-6 receptor subunit beta; Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding o [...] |
| KDM4C protein network | https://string-db.org/network/9606.ENSP00000370710 | Lysine-specific demethylase 4C; Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethyla [...] |
| ADARB2 protein network | https://string-db.org/network/9606.ENSP00000370713 | Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of bindi [...] |
| ASMTL protein network | https://string-db.org/network/9606.ENSP00000370718 | N-acetylserotonin O-methyltransferase-like protein; Unknown. The presence of the putative catalytic domain of S-adenosyl-L-methionine binding argues for a methyltransferase activity; In the N-ter [...] |
| ITSN1 protein network | https://string-db.org/network/9606.ENSP00000370719 | Intersectin-1; Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffi [...] |
| FAM49A protein network | https://string-db.org/network/9606.ENSP00000370724 | Protein FAM49A; Family with sequence similarity 49 member A; Belongs to the FAM49 family |
| TMEM165 protein network | https://string-db.org/network/9606.ENSP00000370736 | Transmembrane protein 165; May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation |
| GLDC protein network | https://string-db.org/network/9606.ENSP00000370737 | Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its p [...] |
| THUMPD1 protein network | https://string-db.org/network/9606.ENSP00000370741 | THUMP domain-containing protein 1; Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation |
| ITPR2 protein network | https://string-db.org/network/9606.ENSP00000370744 | Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP b [...] |
| DDX1 protein network | https://string-db.org/network/9606.ENSP00000370745 | ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses AT [...] |
| IDI1 protein network | https://string-db.org/network/9606.ENSP00000370748 | Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosp [...] |
| RDH11 protein network | https://string-db.org/network/9606.ENSP00000370750 | Retinol dehydrogenase 11; Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-tra [...] |
| LYRM5 protein network | https://string-db.org/network/9606.ENSP00000370761 | Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB [...] |
| GP2 protein network | https://string-db.org/network/9606.ENSP00000370767 | Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2 |
| C17orf107 protein network | https://string-db.org/network/9606.ENSP00000370770 | Uncharacterized protein C17orf107; Chromosome 17 open reading frame 107 |
| CDC20B protein network | https://string-db.org/network/9606.ENSP00000370781 | Cell division cycle protein 20 homolog B; WD repeat domain containing; Belongs to the WD repeat CDC20/Fizzy family |
| MBD3L2 protein network | https://string-db.org/network/9606.ENSP00000370800 | methyl-CpG binding domain protein 3 like 2; Belongs to the MBD3L family |
| MBD3L4 protein network | https://string-db.org/network/9606.ENSP00000370801 | methyl-CpG binding domain protein 3 like 4 |
| CCP110 protein network | https://string-db.org/network/9606.ENSP00000370803 | Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration wi [...] |
| SLC25A6 protein network | https://string-db.org/network/9606.ENSP00000370808 | ADP/ATP translocase 3; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition po [...] |
| ESM1 protein network | https://string-db.org/network/9606.ENSP00000370812 | Endothelial cell-specific molecule 1; Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions |
| HR protein network | https://string-db.org/network/9606.ENSP00000370826 | Lysine-specific demethylase hairless; Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair b [...] |
| SGCB protein network | https://string-db.org/network/9606.ENSP00000370839 | Beta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix |
| IL33 protein network | https://string-db.org/network/9606.ENSP00000370842 | Interleukin-33; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th [...] |
| ITPRIPL2 protein network | https://string-db.org/network/9606.ENSP00000370849 | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2; ITPRIP like 2 |
| TGM3 protein network | https://string-db.org/network/9606.ENSP00000370867 | Protein-glutamine gamma-glutamyltransferase E; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjug [...] |
| OCIAD1 protein network | https://string-db.org/network/9606.ENSP00000370882 | OCIA domain-containing protein 1; Maintains stem cell potency (By similarity). Increases STAT3 phosphorylation and controls ERK phosphorylation (By similarity). May act as a scaffold, increasing [...] |
| MLANA protein network | https://string-db.org/network/9606.ENSP00000370886 | Melanoma antigen recognized by T-cells 1; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of me [...] |
| DENND1C protein network | https://string-db.org/network/9606.ENSP00000370889 | DENN domain-containing protein 1C; Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab prote [...] |
| STK35 protein network | https://string-db.org/network/9606.ENSP00000370891 | Serine/threonine kinase 35; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| GREB1 protein network | https://string-db.org/network/9606.ENSP00000370896 | Protein GREB1; May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers |
| PKD1P1 protein network | https://string-db.org/network/9606.ENSP00000370908 | Protein LOC101930008 |
| TEC protein network | https://string-db.org/network/9606.ENSP00000370912 | Tyrosine-protein kinase Tec; Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regu [...] |
| E2F6 protein network | https://string-db.org/network/9606.ENSP00000370936 | Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCC [...] |
| CDK8 protein network | https://string-db.org/network/9606.ENSP00000370938 | Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridg [...] |
| NPSR1 protein network | https://string-db.org/network/9606.ENSP00000370950 | Neuropeptide S receptor; G-protein coupled receptor for neuropeptide S (NPS). Promotes mobilization of intracellular Ca(2+) stores. Inhibits cell growth in response to NPS binding. Involved in pa [...] |
| GGT6 protein network | https://string-db.org/network/9606.ENSP00000370962 | Glutathione hydrolase 6; Cleaves glutathione conjugates; Gamma-glutamyltransferases |
| CRYZL1 protein network | https://string-db.org/network/9606.ENSP00000370966 | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily |
| MYBBP1A protein network | https://string-db.org/network/9606.ENSP00000370968 | Myb-binding protein 1A; May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase acti [...] |
| LZTS1 protein network | https://string-db.org/network/9606.ENSP00000370981 | Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle a [...] |
| COMMD8 protein network | https://string-db.org/network/9606.ENSP00000370984 | COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B |
| CD274 protein network | https://string-db.org/network/9606.ENSP00000370989 | Programmed cell death 1 ligand 1; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. I [...] |
| SHOX protein network | https://string-db.org/network/9606.ENSP00000370990 | Short stature homeobox protein; Controls fundamental aspects of growth and development; Belongs to the paired homeobox family. Bicoid subfamily |
| C2orf50 protein network | https://string-db.org/network/9606.ENSP00000370997 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50 |
| RNF6 protein network | https://string-db.org/network/9606.ENSP00000371000 | E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regu [...] |
| SIRPB1 protein network | https://string-db.org/network/9606.ENSP00000371018 | Signal-regulatory protein beta-1; Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the r [...] |
| SIRPD protein network | https://string-db.org/network/9606.ENSP00000371036 | Signal regulatory protein delta |
| CATSPERD protein network | https://string-db.org/network/9606.ENSP00000371037 | Cation channel sperm-associated protein subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm [...] |
| RLN2 protein network | https://string-db.org/network/9606.ENSP00000371040 | Prorelaxin H2; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy [...] |
| ZZEF1 protein network | https://string-db.org/network/9606.ENSP00000371051 | Zinc finger ZZ-type and EF-hand domain containing 1 |
| INSL6 protein network | https://string-db.org/network/9606.ENSP00000371054 | Insulin-like peptide INSL6; May have a role in sperm development and fertilization |
| C5orf51 protein network | https://string-db.org/network/9606.ENSP00000371061 | UPF0600 protein C5orf51; Chromosome 5 open reading frame 51; Belongs to the UPF0600 family |
| JAK2 protein network | https://string-db.org/network/9606.ENSP00000371067 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling e [...] |
| ATP8A2 protein network | https://string-db.org/network/9606.ENSP00000371070 | Phospholipid-transporting ATPase IB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| PLCXD1 protein network | https://string-db.org/network/9606.ENSP00000371073 | PI-PLC X domain-containing protein 1; Phosphatidylinositol specific phospholipase C X domain containing 1; Pseudoautosomal region 1 |
| ATP8A1 protein network | https://string-db.org/network/9606.ENSP00000371084 | Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| BAIAP2L2 protein network | https://string-db.org/network/9606.ENSP00000371085 | Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to [...] |
| NOL10 protein network | https://string-db.org/network/9606.ENSP00000371101 | Nucleolar protein 10; WD repeat domain containing; Belongs to the WD repeat NOL10/ENP2 family |
| GCAT protein network | https://string-db.org/network/9606.ENSP00000371110 | 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Glycine C-acetyltransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family |
| GAGE12E protein network | https://string-db.org/network/9606.ENSP00000371117 | Belongs to the GAGE family |
| NUTM2A protein network | https://string-db.org/network/9606.ENSP00000371126 | NUT family member 2A |
| HMG20A protein network | https://string-db.org/network/9606.ENSP00000371133 | High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer [...] |
| GAGE12H protein network | https://string-db.org/network/9606.ENSP00000371141 | G antigen 12H |
| ASAH1 protein network | https://string-db.org/network/9606.ENSP00000371152 | Acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid |
| NUPL1 protein network | https://string-db.org/network/9606.ENSP00000371155 | Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane; Belongs to the NUP58 family |
| RCL1 protein network | https://string-db.org/network/9606.ENSP00000371169 | RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 tha [...] |
| CATSPER2 protein network | https://string-db.org/network/9606.ENSP00000371180 | Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...] |
| CPPED1 protein network | https://string-db.org/network/9606.ENSP00000371193 | Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. M [...] |
| LSP1 protein network | https://string-db.org/network/9606.ENSP00000371194 | Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis |
| ARRDC5 protein network | https://string-db.org/network/9606.ENSP00000371200 | Arrestin domain containing 5; Belongs to the arrestin family |
| NSUN7 protein network | https://string-db.org/network/9606.ENSP00000371201 | Putative methyltransferase NSUN7; May have S-adenosyl-L-methionine-dependent methyl- transferase activity; NOP2/Sun RNA methyltransferase family |
| TMPRSS6 protein network | https://string-db.org/network/9606.ENSP00000371211 | Transmembrane protease serine 6; Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator [...] |
| RBM47 protein network | https://string-db.org/network/9606.ENSP00000371212 | RNA-binding protein 47; RNA binding motif containing; Belongs to the RRM RBM47 family |
| RHOH protein network | https://string-db.org/network/9606.ENSP00000371219 | Rho-related GTP-binding protein RhoH; Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen rec [...] |
| MTMR6 protein network | https://string-db.org/network/9606.ENSP00000371221 | Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreas [...] |
| AK3 protein network | https://string-db.org/network/9606.ENSP00000371230 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotrans [...] |
| SDCBP2 protein network | https://string-db.org/network/9606.ENSP00000371233 | Syntenin-2; Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival; PDZ domain containing |
| CYS1 protein network | https://string-db.org/network/9606.ENSP00000371234 | Cystin-1; Cystin 1 |
| GART protein network | https://string-db.org/network/9606.ENSP00000371253 | Trifunctional purine biosynthetic protein adenosine-3; Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; In the central s [...] |
| YWHAQ protein network | https://string-db.org/network/9606.ENSP00000371267 | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognit [...] |
| PLIN5 protein network | https://string-db.org/network/9606.ENSP00000371272 | Perilipin-5; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to t [...] |
| CDC37L1 protein network | https://string-db.org/network/9606.ENSP00000371278 | Hsp90 co-chaperone Cdc37-like 1; Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90 |
| CTNS protein network | https://string-db.org/network/9606.ENSP00000371294 | Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degr [...] |
| SNPH protein network | https://string-db.org/network/9606.ENSP00000371297 | Syntaphilin; Inhibits SNARE complex formation by absorbing free syntaxin-1 |
| PPAPDC2 protein network | https://string-db.org/network/9606.ENSP00000371307 | Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunit [...] |
| CENPJ protein network | https://string-db.org/network/9606.ENSP00000371308 | Centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in [...] |
| TMEM74B protein network | https://string-db.org/network/9606.ENSP00000371318 | Transmembrane protein 74B |
| RFC1 protein network | https://string-db.org/network/9606.ENSP00000371321 | Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds t [...] |
| KLRC2 protein network | https://string-db.org/network/9606.ENSP00000371327 | NKG2-C type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells; C-type lectin domain containing |
| KLRC3 protein network | https://string-db.org/network/9606.ENSP00000371328 | Killer cell lectin-like receptor subfamily C, member 3; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells; C-type lectin domain [...] |
| TNNI2 protein network | https://string-db.org/network/9606.ENSP00000371331 | Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase act [...] |
| KLRD1 protein network | https://string-db.org/network/9606.ENSP00000371333 | Natural killer cells antigen CD94; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells; C-type lectin domain containing |
| TNK2 protein network | https://string-db.org/network/9606.ENSP00000371341 | Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine- protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Tran [...] |
| METTL22 protein network | https://string-db.org/network/9606.ENSP00000371345 | Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN; Belongs to the methyltransferase superfamily. METTL22 family |
| ANGPT4 protein network | https://string-db.org/network/9606.ENSP00000371347 | Angiopoietin-4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis; Fibrinogen C domai [...] |
| TMEM52B protein network | https://string-db.org/network/9606.ENSP00000371348 | Transmembrane protein 52B |
| NADK2 protein network | https://string-db.org/network/9606.ENSP00000371362 | NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. Also has weak NADH kinas [...] |
| TMEM156 protein network | https://string-db.org/network/9606.ENSP00000371364 | Transmembrane protein 156 |
| OR1A2 protein network | https://string-db.org/network/9606.ENSP00000371377 | Olfactory receptor 1A2; Odorant receptor; Olfactory receptors, family 1 |
| SRXN1 protein network | https://string-db.org/network/9606.ENSP00000371388 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act o [...] |
| PGM2 protein network | https://string-db.org/network/9606.ENSP00000371393 | Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the in [...] |
| SYT8 protein network | https://string-db.org/network/9606.ENSP00000371394 | Synaptotagmin-8; Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. M [...] |
| FAM43A protein network | https://string-db.org/network/9606.ENSP00000371397 | Protein FAM43A; Family with sequence similarity 43 member A; Belongs to the FAM43 family |
| GLIS3 protein network | https://string-db.org/network/9606.ENSP00000371398 | Zinc finger protein GLIS3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity); Zinc fingers C2H2-type |
| PARP4 protein network | https://string-db.org/network/9606.ENSP00000371419 | poly(ADP-ribose) polymerase family member 4 |
| GPNMB protein network | https://string-db.org/network/9606.ENSP00000371420 | Transmembrane glycoprotein NMB; Could be a melanogenic enzyme; Belongs to the PMEL/NMB family |
| RFX3 protein network | https://string-db.org/network/9606.ENSP00000371434 | Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocili [...] |
| DNAJC21 protein network | https://string-db.org/network/9606.ENSP00000371451 | DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S [...] |
| RAD1 protein network | https://string-db.org/network/9606.ENSP00000371469 | Cell cycle checkpoint protein RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage b [...] |
| RSAD2 protein network | https://string-db.org/network/9606.ENSP00000371471 | Radical S-adenosyl methionine domain-containing protein 2; Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induce [...] |
| NIN protein network | https://string-db.org/network/9606.ENSP00000371472 | Ninein; Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtub [...] |
| TP53BP1 protein network | https://string-db.org/network/9606.ENSP00000371475 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key ro [...] |
| SLC34A2 protein network | https://string-db.org/network/9606.ENSP00000371483 | Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intesti [...] |
| C1QTNF3 protein network | https://string-db.org/network/9606.ENSP00000371497 | Complement C1q tumor necrosis factor-related protein 3; C1q and TNF related 3 |
| C1QTNF9 protein network | https://string-db.org/network/9606.ENSP00000371503 | Complement C1q and tumor necrosis factor-related protein 9A; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways (By similarity); C1q and TNF related |
| CLEC6A protein network | https://string-db.org/network/9606.ENSP00000371505 | C-type lectin domain family 6 member A; Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the [...] |
| SGCZ protein network | https://string-db.org/network/9606.ENSP00000371512 | Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May p [...] |
| KCNV2 protein network | https://string-db.org/network/9606.ENSP00000371514 | Potassium voltage-gated channel subfamily V member 2; Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values; Belo [...] |
| AMACR protein network | https://string-db.org/network/9606.ENSP00000371517 | Alpha-methylacyl-CoA racemase; Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers; Belongs [...] |
| C22orf42 protein network | https://string-db.org/network/9606.ENSP00000371529 | Uncharacterized protein C22orf42; Chromosome 22 open reading frame 42 |
| VLDLR protein network | https://string-db.org/network/9606.ENSP00000371532 | Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated p [...] |
| SEPSECS protein network | https://string-db.org/network/9606.ENSP00000371535 | O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis |
| LGI2 protein network | https://string-db.org/network/9606.ENSP00000371548 | Leucine rich repeat LGI family member 2 |
| NANOGNB protein network | https://string-db.org/network/9606.ENSP00000371553 | NANOG neighbor homeobox |
| SOD3 protein network | https://string-db.org/network/9606.ENSP00000371554 | Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen |
| TSSC1 protein network | https://string-db.org/network/9606.ENSP00000371559 | EARP-interacting protein; Tumor suppressing subtransferable candidate 1 |
| C1QTNF9B protein network | https://string-db.org/network/9606.ENSP00000371572 | Complement C1q and tumor necrosis factor-related protein 9B; C1q and TNF related 9B |
| MTMR12 protein network | https://string-db.org/network/9606.ENSP00000371577 | Myotubularin-related protein 12; Catalytically inactive phosphatase that plays a role as an adapter for the phosphatase myotubularin to regulate myotubularin intracellular location; Belongs to th [...] |
| PISD protein network | https://string-db.org/network/9606.ENSP00000371586 | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid meta [...] |
| KCNIP4 protein network | https://string-db.org/network/9606.ENSP00000371587 | Kv channel-interacting protein 4; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and [...] |
| GNG7 protein network | https://string-db.org/network/9606.ENSP00000371594 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| KRTAP5-6 protein network | https://string-db.org/network/9606.ENSP00000371595 | Keratin-associated protein 5-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| KRTAP5-1 protein network | https://string-db.org/network/9606.ENSP00000371606 | Keratin-associated protein 5-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| MIPEP protein network | https://string-db.org/network/9606.ENSP00000371607 | Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size; M3 metallopeptidases |
| BRSK2 protein network | https://string-db.org/network/9606.ENSP00000371614 | Serine/threonine-protein kinase BRSK2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates [...] |
| IGF2BP2 protein network | https://string-db.org/network/9606.ENSP00000371634 | Insulin-like growth factor 2 mRNA-binding protein 2; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows m [...] |
| DEFB135 protein network | https://string-db.org/network/9606.ENSP00000371643 | Beta-defensin 135; Has antibacterial activity; Defensins, beta |
| DEFB136 protein network | https://string-db.org/network/9606.ENSP00000371644 | Beta-defensin 136; Has antibacterial activity; Defensins, beta |
| LCORL protein network | https://string-db.org/network/9606.ENSP00000371661 | Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatog [...] |
| DCAF16 protein network | https://string-db.org/network/9606.ENSP00000371682 | DDB1- and CUL4-associated factor 16; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| DMRT2 protein network | https://string-db.org/network/9606.ENSP00000371686 | Doublesex- and mab-3-related transcription factor 2; Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific m [...] |
| CDH12 protein network | https://string-db.org/network/9606.ENSP00000371689 | Cadherin-12; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| TNFRSF19 protein network | https://string-db.org/network/9606.ENSP00000371693 | Tumor necrosis factor receptor superfamily member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death; Tumor necrosis factor receptor superfamily |
| DMRT1 protein network | https://string-db.org/network/9606.ENSP00000371711 | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell [...] |
| ZG16B protein network | https://string-db.org/network/9606.ENSP00000371715 | Zymogen granule protein 16B; Belongs to the jacalin lectin family |
| NRSN2 protein network | https://string-db.org/network/9606.ENSP00000371728 | Neurensin-2; May play a role in maintenance and/or transport of vesicles |
| SACS protein network | https://string-db.org/network/9606.ENSP00000371735 | Sacsin; Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins; DNAJ heat shock proteins |
| FGFBP1 protein network | https://string-db.org/network/9606.ENSP00000371770 | Fibroblast growth factor-binding protein 1; Acts as a carrier protein that release fibroblast- binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic act [...] |
| OLIG1 protein network | https://string-db.org/network/9606.ENSP00000371785 | Oligodendrocyte transcription factor 1; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neur [...] |
| ONECUT3 protein network | https://string-db.org/network/9606.ENSP00000371786 | One cut domain family member 3; Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR (By similarity); CUT [...] |
| FGF9 protein network | https://string-db.org/network/9606.ENSP00000371790 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth a [...] |
| FSCN1 protein network | https://string-db.org/network/9606.ENSP00000371798 | Fascin; Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane [...] |
| RNF215 protein network | https://string-db.org/network/9606.ENSP00000371800 | Ring finger protein 215 |
| FBXL18 protein network | https://string-db.org/network/9606.ENSP00000371805 | F-box/LRR-repeat protein 18; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| MICU2 protein network | https://string-db.org/network/9606.ENSP00000371811 | Calcium uptake protein 2, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a dis [...] |
| DEFB132 protein network | https://string-db.org/network/9606.ENSP00000371813 | Beta-defensin 132; Has antibacterial activity; Defensins, beta |
| C9orf66 protein network | https://string-db.org/network/9606.ENSP00000371824 | Uncharacterized protein C9orf66; Chromosome 9 open reading frame 66 |
| DEFB127 protein network | https://string-db.org/network/9606.ENSP00000371825 | Beta-defensin 127; Has antibacterial activity; Defensins, beta |
| DEFB126 protein network | https://string-db.org/network/9606.ENSP00000371835 | Beta-defensin 126; Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm [...] |
| DEAF1 protein network | https://string-db.org/network/9606.ENSP00000371846 | Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. D [...] |
| DEFB125 protein network | https://string-db.org/network/9606.ENSP00000371847 | Beta-defensin 125; Has antibacterial activity; Defensins, beta |
| NOP2 protein network | https://string-db.org/network/9606.ENSP00000371858 | Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) [...] |
| SLC35G5 protein network | https://string-db.org/network/9606.ENSP00000371872 | Solute carrier family 35 member G5 |
| NKX3-2 protein network | https://string-db.org/network/9606.ENSP00000371875 | Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric mor [...] |
| JMJD7-PLA2G4B protein network | https://string-db.org/network/9606.ENSP00000371886 | JMJD7-PLA2G4B readthrough |
| ARHGAP5 protein network | https://string-db.org/network/9606.ENSP00000371897 | Rho GTPase-activating protein 5; GTPase-activating protein for Rho family members. May play a role in the reduction of the p21rasGTPase-activating potential of RASA1/p120GAP |
| ZDHHC20 protein network | https://string-db.org/network/9606.ENSP00000371905 | Probable palmitoyltransferase ZDHHC20; Zinc finger DHHC-type containing 20; Belongs to the DHHC palmitoyltransferase family |
| RP1L1 protein network | https://string-db.org/network/9606.ENSP00000371923 | Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors (By similarity); D [...] |
| GPR78 protein network | https://string-db.org/network/9606.ENSP00000371927 | G-protein coupled receptor 78; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in [...] |
| HTR3D protein network | https://string-db.org/network/9606.ENSP00000371929 | 5-hydroxytryptamine receptor 3D; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| TAS2R1 protein network | https://string-db.org/network/9606.ENSP00000371932 | Taste receptor type 2 member 1; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| SEMA5A protein network | https://string-db.org/network/9606.ENSP00000371936 | Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory e [...] |
| FOXD4 protein network | https://string-db.org/network/9606.ENSP00000371940 | Forkhead box D4 |
| CD9 protein network | https://string-db.org/network/9606.ENSP00000371958 | CD9 antigen; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion; [...] |
| KCNA1 protein network | https://string-db.org/network/9606.ENSP00000371985 | Potassium voltage-gated channel subfamily A member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the centra [...] |
| NYNRIN protein network | https://string-db.org/network/9606.ENSP00000371994 | Protein NYNRIN; NYN domain and retroviral integrase containing |
| DNAJC19 protein network | https://string-db.org/network/9606.ENSP00000372005 | Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inne [...] |
| CHEK2 protein network | https://string-db.org/network/9606.ENSP00000372023 | Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presen [...] |
| LATS2 protein network | https://string-db.org/network/9606.ENSP00000372035 | Serine/threonine-protein kinase LATS2; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...] |
| IRX2 protein network | https://string-db.org/network/9606.ENSP00000372056 | Iroquois-class homeodomain protein IRX-2; TALE class homeoboxes and pseudogenes |
| IFITM5 protein network | https://string-db.org/network/9606.ENSP00000372059 | Interferon-induced transmembrane protein 5; Required for normal bone mineralization; Belongs to the CD225/Dispanin family |
| PRMT8 protein network | https://string-db.org/network/9606.ENSP00000372067 | Protein arginine N-methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine ( [...] |
| RAD51 protein network | https://string-db.org/network/9606.ENSP00000372088 | DNA repair protein RAD51 homolog 1; Fanconi anemia complementation groups |
| FAHD1 protein network | https://string-db.org/network/9606.ENSP00000372112 | Acylpyruvase FAHD1, mitochondrial; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. Also has oxaloacetate decarboxylase activity |
| DEFA1B protein network | https://string-db.org/network/9606.ENSP00000372136 | Defensin, alpha 1B; Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins are t [...] |
| DEFA1 protein network | https://string-db.org/network/9606.ENSP00000372139 | Neutrophil defensin 1; Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram- negative and Gram-positive bacteria. Defensins ar [...] |
| PSME1 protein network | https://string-db.org/network/9606.ENSP00000372155 | Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I bindin [...] |
| DOK6 protein network | https://string-db.org/network/9606.ENSP00000372160 | Docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret- [...] |
| CACNA2D4 protein network | https://string-db.org/network/9606.ENSP00000372169 | Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...] |
| MSX1 protein network | https://string-db.org/network/9606.ENSP00000372170 | Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the develo [...] |
| SIRT3 protein network | https://string-db.org/network/9606.ENSP00000372191 | NAD-dependent protein deacetylase sirtuin-3, mitochondrial; NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known t [...] |
| CLCN7 protein network | https://string-db.org/network/9606.ENSP00000372193 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysoso [...] |
| URB1 protein network | https://string-db.org/network/9606.ENSP00000372199 | Nucleolar pre-ribosomal-associated protein 1; Armadillo-like helical domain containing |
| TMEM128 protein network | https://string-db.org/network/9606.ENSP00000372201 | Transmembrane protein 128 |
| N6AMT2 protein network | https://string-db.org/network/9606.ENSP00000372206 | EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79' |
| BET1L protein network | https://string-db.org/network/9606.ENSP00000372210 | BET1-like protein; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity); SNAREs |
| SERPINB5 protein network | https://string-db.org/network/9606.ENSP00000372221 | Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characte [...] |
| KRTAP19-8 protein network | https://string-db.org/network/9606.ENSP00000372272 | Keratin-associated protein 19-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| FBXO25 protein network | https://string-db.org/network/9606.ENSP00000372274 | F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) pr [...] |
| KRTAP20-3 protein network | https://string-db.org/network/9606.ENSP00000372276 | Keratin-associated protein 20-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP20-4 protein network | https://string-db.org/network/9606.ENSP00000372278 | Putative keratin-associated protein 20-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP [...] |
| KRTAP22-2 protein network | https://string-db.org/network/9606.ENSP00000372281 | Keratin-associated protein 22-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP27-1 protein network | https://string-db.org/network/9606.ENSP00000372286 | Keratin-associated protein 27-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| GJB2 protein network | https://string-db.org/network/9606.ENSP00000372295 | Gap junction beta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| MSLN protein network | https://string-db.org/network/9606.ENSP00000372313 | Mesothelin; Membrane-anchored forms may play a role in cellular adhesion |
| FECH protein network | https://string-db.org/network/9606.ENSP00000372326 | Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX; Belongs to the ferrochelatase family |
| NELFA protein network | https://string-db.org/network/9606.ENSP00000372335 | Negative elongation factor A; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via a [...] |
| WHSC1 protein network | https://string-db.org/network/9606.ENSP00000372351 | Histone-lysine N-methyltransferase NSD2; Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. Isoform 2 may act as a transcription regulator that binds DNA and [...] |
| ZMYM5 protein network | https://string-db.org/network/9606.ENSP00000372361 | Zinc finger MYM-type protein 5; Functions as a transcriptional regulator; Zinc fingers MYM-type |
| SLC7A4 protein network | https://string-db.org/network/9606.ENSP00000372390 | Cationic amino acid transporter 4; Involved in the transport of the cationic amino acids (arginine, lysine and ornithine); Solute carriers |
| TMEM129 protein network | https://string-db.org/network/9606.ENSP00000372394 | E3 ubiquitin-protein ligase TM129; E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins [...] |
| RNASE13 protein network | https://string-db.org/network/9606.ENSP00000372410 | Probable inactive ribonuclease-like protein 13; Does not exhibit any ribonuclease activity |
| METTL17 protein network | https://string-db.org/network/9606.ENSP00000372445 | Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family |
| CTIF protein network | https://string-db.org/network/9606.ENSP00000372459 | CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after [...] |
| SNRNP25 protein network | https://string-db.org/network/9606.ENSP00000372482 | Small nuclear ribonucleoprotein U11/U12 subunit 25 |
| CCDC178 protein network | https://string-db.org/network/9606.ENSP00000372576 | Coiled-coil domain containing 178 |
| SLC25A52 protein network | https://string-db.org/network/9606.ENSP00000372612 | Solute carrier family 25 member 52 |
| PRR23A protein network | https://string-db.org/network/9606.ENSP00000372649 | Proline-rich protein 23A; Proline rich 23A; Belongs to the PRR23 family |
| FOXL2NB protein network | https://string-db.org/network/9606.ENSP00000372651 | FOXL2 neighbor |
| AQP4 protein network | https://string-db.org/network/9606.ENSP00000372654 | Aquaporin-4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system; Belongs to the MIP/aquaporin (TC 1.A.8) fam [...] |
| NME9 protein network | https://string-db.org/network/9606.ENSP00000372667 | Thioredoxin domain-containing protein 6; NME/NM23 family member 9 |
| STAG1 protein network | https://string-db.org/network/9606.ENSP00000372689 | Cohesin subunit SA-1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring [...] |
| TMEM241 protein network | https://string-db.org/network/9606.ENSP00000372720 | Transmembrane protein 241 |
| LY6G5C protein network | https://string-db.org/network/9606.ENSP00000372724 | Lymphocyte antigen 6 complex locus protein G5c; May have a role in hematopoietic cell differentiation; LY6/PLAUR domain containing |
| CHRM5 protein network | https://string-db.org/network/9606.ENSP00000372750 | Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...] |
| RNMT protein network | https://string-db.org/network/9606.ENSP00000372804 | mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5'-cap struc [...] |
| NEK11 protein network | https://string-db.org/network/9606.ENSP00000372857 | Serine/threonine-protein kinase Nek11; Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on [...] |
| LY6G6E protein network | https://string-db.org/network/9606.ENSP00000372910 | Lymphocyte antigen 6 family member G6E; LY6/PLAUR domain containing |
| HMCES protein network | https://string-db.org/network/9606.ENSP00000372955 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader [...] |
| LRRC30 protein network | https://string-db.org/network/9606.ENSP00000372959 | Leucine-rich repeat-containing protein 30; Leucine rich repeat containing 30 |
| OR12D2 protein network | https://string-db.org/network/9606.ENSP00000373047 | Olfactory receptor 12D2; Odorant receptor; Olfactory receptors, family 12 |
| TXNRD3 protein network | https://string-db.org/network/9606.ENSP00000373066 | Thioredoxin reductase 3; Glutaredoxin domain containing |
| UROC1 protein network | https://string-db.org/network/9606.ENSP00000373073 | Urocanate hydratase 1 |
| OR2H2 protein network | https://string-db.org/network/9606.ENSP00000373136 | Olfactory receptor 2H2; Odorant receptor; Olfactory receptors, family 2 |
| PTPLB protein network | https://string-db.org/network/9606.ENSP00000373153 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic proces [...] |
| DRD3 protein network | https://string-db.org/network/9606.ENSP00000373169 | D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation; Belongs to the G-protein coupled receptor 1 family |
| GTPBP8 protein network | https://string-db.org/network/9606.ENSP00000373176 | GTP binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. EngB GTPase family |
| LNP1 protein network | https://string-db.org/network/9606.ENSP00000373191 | Leukemia NUP98 fusion partner 1 |
| OR5K1 protein network | https://string-db.org/network/9606.ENSP00000373193 | Olfactory receptor 5K1; Odorant receptor; Olfactory receptors, family 5 |
| OR5K3 protein network | https://string-db.org/network/9606.ENSP00000373194 | Olfactory receptor 5K3; Odorant receptor; Olfactory receptors, family 5 |
| OR5H15 protein network | https://string-db.org/network/9606.ENSP00000373195 | Olfactory receptor 5H15; Odorant receptor; Olfactory receptors, family 5 |
| OR5H6 protein network | https://string-db.org/network/9606.ENSP00000373196 | Olfactory receptor 5H6; Odorant receptor; Olfactory receptors, family 5 |
| EOGT protein network | https://string-db.org/network/9606.ENSP00000373206 | EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins res [...] |
| CADPS protein network | https://string-db.org/network/9606.ENSP00000373215 | Calcium-dependent secretion activator 1; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogen [...] |
| CSPG5 protein network | https://string-db.org/network/9606.ENSP00000373244 | Chondroitin sulfate proteoglycan 5; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation |
| TRIM71 protein network | https://string-db.org/network/9606.ENSP00000373272 | E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). B [...] |
| ZNF860 protein network | https://string-db.org/network/9606.ENSP00000373274 | Zinc finger protein 860; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RBMS3 protein network | https://string-db.org/network/9606.ENSP00000373277 | RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides; RNA binding motif containing |
| ZCWPW2 protein network | https://string-db.org/network/9606.ENSP00000373278 | Zinc finger CW-type and PWWP domain containing 2 |
| COLQ protein network | https://string-db.org/network/9606.ENSP00000373298 | Acetylcholinesterase collagenic tail peptide; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina |
| SH3BP5 protein network | https://string-db.org/network/9606.ENSP00000373301 | SH3 domain-binding protein 5; Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR [...] |
| CCDC174 protein network | https://string-db.org/network/9606.ENSP00000373304 | Coiled-coil domain-containing protein 174; Probably involved in neuronal development |
| SEC13 protein network | https://string-db.org/network/9606.ENSP00000373312 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles; B [...] |
| IL17RE protein network | https://string-db.org/network/9606.ENSP00000373325 | Interleukin-17 receptor E; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator [...] |
| CIDEC protein network | https://string-db.org/network/9606.ENSP00000373328 | Cell death activator CIDE-3; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes d [...] |
| RPUSD3 protein network | https://string-db.org/network/9606.ENSP00000373331 | Mitochondrial mRNA pseudouridine synthase RPUSD3; Major enzyme responsible for the conversion of uridine to pseudouridine (PSI) at position 390 in mitochondrial COXI (MT- CO1) mRNA and at positio [...] |
| BRPF1 protein network | https://string-db.org/network/9606.ENSP00000373340 | Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 [...] |
| CPNE9 protein network | https://string-db.org/network/9606.ENSP00000373343 | Copine-9; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocyt [...] |
| SRGAP3 protein network | https://string-db.org/network/9606.ENSP00000373347 | SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons; F-BAR domain containing |
| SETMAR protein network | https://string-db.org/network/9606.ENSP00000373354 | Histone-lysine N-methyltransferase SETMAR; Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled [...] |
| FAM131A protein network | https://string-db.org/network/9606.ENSP00000373360 | Protein FAM131A; Family with sequence similarity 131 member A; Belongs to the FAM131 family |
| GOLM1 protein network | https://string-db.org/network/9606.ENSP00000373364 | Golgi membrane protein 1; Unknown. Cellular response protein to viral infection; Belongs to the GOLM1/CASC4 family |
| FLG2 protein network | https://string-db.org/network/9606.ENSP00000373370 | Filaggrin-2; S100 fused type protein family; In the N-terminal section; belongs to the S-100 family |
| PIP5KL1 protein network | https://string-db.org/network/9606.ENSP00000373399 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4 [...] |
| MRPL2 protein network | https://string-db.org/network/9606.ENSP00000373404 | Mitochondrial ribosomal protein L2; Belongs to the universal ribosomal protein uL2 family |
| UFSP1 protein network | https://string-db.org/network/9606.ENSP00000373413 | Inactive Ufm1-specific protease 1; UFM1 specific peptidase 1; Belongs to the peptidase C78 family |
| RUFY2 protein network | https://string-db.org/network/9606.ENSP00000373420 | RUN and FYVE domain containing 2; Zinc fingers FYVE-type |
| LAMB4 protein network | https://string-db.org/network/9606.ENSP00000373433 | Laminin subunit beta-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| SPAG1 protein network | https://string-db.org/network/9606.ENSP00000373450 | Sperm-associated antigen 1; May play a role in the cytoplasmic assembly of the ciliary dynein arms (By similarity). May play a role in fertilization. Binds GTP and has GTPase activity; Tetratrico [...] |
| ADAMTS7 protein network | https://string-db.org/network/9606.ENSP00000373472 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP; ADAM metallopeptidases with thrombospondin type 1 motif |
| METTL14 protein network | https://string-db.org/network/9606.ENSP00000373474 | N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6- methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs an [...] |
| GPX3 protein network | https://string-db.org/network/9606.ENSP00000373477 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione; Selenoprot [...] |
| KRT18 protein network | https://string-db.org/network/9606.ENSP00000373487 | Keratin, type I cytoskeletal 18; Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved [...] |
| C11orf31 protein network | https://string-db.org/network/9606.ENSP00000373509 | Selenoprotein H; May be involved in a redox-related process |
| NOX5 protein network | https://string-db.org/network/9606.ENSP00000373518 | NADPH oxidase 5; Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and sper [...] |
| STAB2 protein network | https://string-db.org/network/9606.ENSP00000373539 | Stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in differen [...] |
| FAM83H protein network | https://string-db.org/network/9606.ENSP00000373565 | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin f [...] |
| CCDC158 protein network | https://string-db.org/network/9606.ENSP00000373566 | Coiled-coil domain containing 158 |
| TYRP1 protein network | https://string-db.org/network/9606.ENSP00000373570 | 5,6-dihydroxyindole-2-carboxylic acid oxidase; Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) [...] |
| FOXI2 protein network | https://string-db.org/network/9606.ENSP00000373572 | Forkhead box protein I2; Possible transcriptional activator; Forkhead boxes |
| ACVRL1 protein network | https://string-db.org/network/9606.ENSP00000373574 | Serine/threonine-protein kinase receptor R3; Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a [...] |
| C6orf163 protein network | https://string-db.org/network/9606.ENSP00000373575 | Uncharacterized protein C6orf163; Chromosome 6 open reading frame 163 |
| C9orf173 protein network | https://string-db.org/network/9606.ENSP00000373583 | Protein STPG3; Chromosome 9 open reading frame 173 |
| C2orf54 protein network | https://string-db.org/network/9606.ENSP00000373586 | Uncharacterized protein C2orf54; Chromosome 2 open reading frame 54 |
| C15orf27 protein network | https://string-db.org/network/9606.ENSP00000373594 | Transmembrane protein 266; Chromosome 15 open reading frame 27 |
| LRRK1 protein network | https://string-db.org/network/9606.ENSP00000373600 | Leucine rich repeat kinase 1; Roco domain containing |
| OTOA protein network | https://string-db.org/network/9606.ENSP00000373610 | Otoancorin; May act as an adhesion molecule; Belongs to the stereocilin family |
| HSPD1 protein network | https://string-db.org/network/9606.ENSP00000373620 | 60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported prote [...] |
| SEPT14 protein network | https://string-db.org/network/9606.ENSP00000373627 | Septin-14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Septins |
| FAM83G protein network | https://string-db.org/network/9606.ENSP00000373647 | Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway |
| KCNQ3 protein network | https://string-db.org/network/9606.ENSP00000373648 | Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-cur [...] |
| C17orf85 protein network | https://string-db.org/network/9606.ENSP00000373657 | Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking [...] |
| C17orf59 protein network | https://string-db.org/network/9606.ENSP00000373669 | BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...] |
| NT5M protein network | https://string-db.org/network/9606.ENSP00000373674 | 5'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')- phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication [...] |
| STK38L protein network | https://string-db.org/network/9606.ENSP00000373684 | Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells |
| TRIP12 protein network | https://string-db.org/network/9606.ENSP00000373696 | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) [...] |
| ALK protein network | https://string-db.org/network/9606.ENSP00000373700 | ALK tyrosine kinase receptor; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an import [...] |
| PP2D1 protein network | https://string-db.org/network/9606.ENSP00000373702 | Protein phosphatase 2C like domain containing 1 |
| SACM1L protein network | https://string-db.org/network/9606.ENSP00000373713 | Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Has low activ [...] |
| DCP2 protein network | https://string-db.org/network/9606.ENSP00000373715 | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphoryl [...] |
| FAM159B protein network | https://string-db.org/network/9606.ENSP00000373726 | Membrane protein FAM159B; Family with sequence similarity 159, member B |
| DENND5B protein network | https://string-db.org/network/9606.ENSP00000373734 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab protein [...] |
| RNF180 protein network | https://string-db.org/network/9606.ENSP00000373752 | E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2; Ring finger proteins |
| RNF20 protein network | https://string-db.org/network/9606.ENSP00000373772 | E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a spec [...] |
| LOXL2 protein network | https://string-db.org/network/9606.ENSP00000373783 | Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in ext [...] |
| FAM169A protein network | https://string-db.org/network/9606.ENSP00000373808 | Soluble lamin-associated protein of 75 kDa; Family with sequence similarity 169 member A; Belongs to the FAM169 family |
| CCDC150 protein network | https://string-db.org/network/9606.ENSP00000373827 | Coiled-coil domain containing 150 |
| CCDC154 protein network | https://string-db.org/network/9606.ENSP00000373828 | Coiled-coil domain containing 154 |
| ITGAD protein network | https://string-db.org/network/9606.ENSP00000373854 | Integrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood [...] |
| ASPDH protein network | https://string-db.org/network/9606.ENSP00000373860 | Putative L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate |
| RYR3 protein network | https://string-db.org/network/9606.ENSP00000373884 | Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. M [...] |
| POU6F1 protein network | https://string-db.org/network/9606.ENSP00000373895 | POU domain, class 6, transcription factor 1; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3'); POU class homeoboxes and pseudogenes |
| DNM2 protein network | https://string-db.org/network/9606.ENSP00000373905 | Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon g [...] |
| GARS protein network | https://string-db.org/network/9606.ENSP00000373918 | Glycine--tRNA ligase; Catalyzes the ligation of glycine to the 3'-end of its cognate tRNA. Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for c [...] |
| PRTG protein network | https://string-db.org/network/9606.ENSP00000373937 | Protogenin; May play a role in anteroposterior axis elongation; Fibronectin type III domain containing |
| CFAP69 protein network | https://string-db.org/network/9606.ENSP00000373948 | Cilia- and flagella-associated protein 69; Armadillo-like helical domain containing |
| FANCA protein network | https://string-db.org/network/9606.ENSP00000373952 | Fanconi anemia group A protein; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in th [...] |
| SMTNL2 protein network | https://string-db.org/network/9606.ENSP00000373964 | Smoothelin-like protein 2; Smoothelin like 2 |
| TRAPPC9 protein network | https://string-db.org/network/9606.ENSP00000373979 | Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May p [...] |
| PRB2 protein network | https://string-db.org/network/9606.ENSP00000374013 | Basic salivary proline-rich protein 2; Proline rich protein BstNI subfamily 2 |
| TM6SF2 protein network | https://string-db.org/network/9606.ENSP00000374014 | Transmembrane 6 superfamily member 2; Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. May function as sterol isomerase; Belongs to the TM6S [...] |
| RPH3A protein network | https://string-db.org/network/9606.ENSP00000374036 | Rabphilin-3A; Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by reg [...] |
| VPS9D1 protein network | https://string-db.org/network/9606.ENSP00000374037 | VPS9 domain containing 1 |
| DNAH6 protein network | https://string-db.org/network/9606.ENSP00000374045 | Dynein heavy chain 6, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| VWA3A protein network | https://string-db.org/network/9606.ENSP00000374049 | Von Willebrand factor A domain containing 3A |
| PTPRN2 protein network | https://string-db.org/network/9606.ENSP00000374069 | Receptor-type tyrosine-protein phosphatase N2; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreati [...] |
| ADAMTS20 protein network | https://string-db.org/network/9606.ENSP00000374071 | A disintegrin and metalloproteinase with thrombospondin motifs 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independ [...] |
| SIGLEC15 protein network | https://string-db.org/network/9606.ENSP00000374125 | Sialic acid-binding Ig-like lectin 15; Binds sialylated glycoproteins; Sialic acid binding Ig like lectins |
| LRP1B protein network | https://string-db.org/network/9606.ENSP00000374135 | Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Low density lipoprotein rec [...] |
| CHRNG protein network | https://string-db.org/network/9606.ENSP00000374145 | Acetylcholine receptor subunit gamma; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting cha [...] |
| SMYD5 protein network | https://string-db.org/network/9606.ENSP00000374152 | SET and MYND domain-containing protein 5; Zinc fingers MYND-type; Belongs to the class V-like SAM-binding methyltransferase superfamily |
| CAMSAP1 protein network | https://string-db.org/network/9606.ENSP00000374183 | Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...] |
| TBR1 protein network | https://string-db.org/network/9606.ENSP00000374205 | T-box brain protein 1; Probable transcriptional regulator involved in developmental processes. Required for normal brain development; T-boxes |
| EP400NL protein network | https://string-db.org/network/9606.ENSP00000374211 | EP400 N-terminal-like protein; EP400 N-terminal like |
| EP400 protein network | https://string-db.org/network/9606.ENSP00000374213 | E1A-binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone [...] |
| ESYT3 protein network | https://string-db.org/network/9606.ENSP00000374218 | Extended synaptotagmin-3; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membran [...] |
| TMEM72 protein network | https://string-db.org/network/9606.ENSP00000374234 | Transmembrane protein 72 |
| NXPE2 protein network | https://string-db.org/network/9606.ENSP00000374237 | NXPE family member 2; Neurexophilin and PC-esterase domain family member 2 |
| SHOX2 protein network | https://string-db.org/network/9606.ENSP00000374240 | Short stature homeobox protein 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure fo [...] |
| GPX2 protein network | https://string-db.org/network/9606.ENSP00000374265 | Glutathione peroxidase 2; Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydr [...] |
| GXYLT2 protein network | https://string-db.org/network/9606.ENSP00000374268 | Glucoside xylosyltransferase 2; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of x [...] |
| CRYBG3 protein network | https://string-db.org/network/9606.ENSP00000374273 | Very large A-kinase anchor protein; Isoform vlAKAP: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA); Beta-gamma crystallin domain containing |
| SSC5D protein network | https://string-db.org/network/9606.ENSP00000374274 | Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D; Binds to extracellular matrix proteins. Binds to pathogen-associated molecular patterns (PAMPs) present on the cell walls [...] |
| RTF1 protein network | https://string-db.org/network/9606.ENSP00000374280 | RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of dev [...] |
| CCDC57 protein network | https://string-db.org/network/9606.ENSP00000374292 | Coiled-coil domain containing 57 |
| LAMA1 protein network | https://string-db.org/network/9606.ENSP00000374309 | Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| EPHA6 protein network | https://string-db.org/network/9606.ENSP00000374323 | Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| FAXC protein network | https://string-db.org/network/9606.ENSP00000374328 | Failed axon connections homolog; May play a role in axonal development |
| TSN protein network | https://string-db.org/network/9606.ENSP00000374332 | Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene [...] |
| HAGHL protein network | https://string-db.org/network/9606.ENSP00000374353 | Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds |
| EXOSC8 protein network | https://string-db.org/network/9606.ENSP00000374354 | Exosome complex component RRP43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrad [...] |
| ZXDC protein network | https://string-db.org/network/9606.ENSP00000374359 | Zinc finger protein ZXDC; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes; Zinc fingers C2H2-type |
| FAM101A protein network | https://string-db.org/network/9606.ENSP00000374377 | Refilin-A; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing c [...] |
| TRMT44 protein network | https://string-db.org/network/9606.ENSP00000374387 | Probable tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Belongs to the TRM44 family |
| GPR149 protein network | https://string-db.org/network/9606.ENSP00000374390 | Probable G-protein coupled receptor 149; Orphan receptor; G protein-coupled receptors, Class A orphans |
| TRMT61A protein network | https://string-db.org/network/9606.ENSP00000374399 | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)- methyladenine at position [...] |
| PKP4 protein network | https://string-db.org/network/9606.ENSP00000374409 | Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques; Armadillo repeat containing |
| ARHGAP8 protein network | https://string-db.org/network/9606.ENSP00000374424 | Rho GTPase activating protein 8; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; BCH domain containing |
| LYST protein network | https://string-db.org/network/9606.ENSP00000374443 | Lysosomal-trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules; BEACH domain containing |
| LRCH1 protein network | https://string-db.org/network/9606.ENSP00000374447 | Leucine-rich repeat and calponin homology domain-containing protein 1; Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC [...] |
| SQSTM1 protein network | https://string-db.org/network/9606.ENSP00000374455 | Sequestosome-1; Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and [...] |
| MRGPRE protein network | https://string-db.org/network/9606.ENSP00000374482 | Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; G protein-coupled receptors, [...] |
| TMEM87A protein network | https://string-db.org/network/9606.ENSP00000374484 | Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN) |
| DNAH17 protein network | https://string-db.org/network/9606.ENSP00000374490 | Dynein heavy chain 17, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| UVSSA protein network | https://string-db.org/network/9606.ENSP00000374501 | UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rap [...] |
| CCDC88C protein network | https://string-db.org/network/9606.ENSP00000374507 | Protein Daple; Negative regulator of the canonical Wnt signaling pathway, acting downstream of DVL to inhibit CTNNB1/Beta-catenin stabilization (By similarity). May also activate the JNK signalin [...] |
| CCNK protein network | https://string-db.org/network/9606.ENSP00000374529 | Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of t [...] |
| RNF216 protein network | https://string-db.org/network/9606.ENSP00000374552 | E3 ubiquitin-protein ligase RNF216; Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting [...] |
| COX16 protein network | https://string-db.org/network/9606.ENSP00000374562 | COX16, cytochrome c oxidase assembly homolog; Belongs to the COX16 family |
| KIF19 protein network | https://string-db.org/network/9606.ENSP00000374566 | Kinesin-like protein KIF19; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips; Kinesins |
| IL17REL protein network | https://string-db.org/network/9606.ENSP00000374633 | Putative interleukin-17 receptor E-like; Interleukin 17 receptor E like |
| TMEM203 protein network | https://string-db.org/network/9606.ENSP00000375053 | Transmembrane protein 203; Involved in the regulation of cellular calcium homeotasis. Required for spermatogenesis |
| NLRP5 protein network | https://string-db.org/network/9606.ENSP00000375063 | NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions; [...] |
| HCAR2 protein network | https://string-db.org/network/9606.ENSP00000375066 | Hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and de [...] |
| BCAS3 protein network | https://string-db.org/network/9606.ENSP00000375067 | Breast carcinoma-amplified sequence 3; Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation an [...] |
| COL23A1 protein network | https://string-db.org/network/9606.ENSP00000375069 | Collagen type XXIII alpha 1 chain; Collagens |
| EID2 protein network | https://string-db.org/network/9606.ENSP00000375073 | EP300-interacting inhibitor of differentiation 2; Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferas [...] |
| KRTAP4-4 protein network | https://string-db.org/network/9606.ENSP00000375076 | Keratin-associated protein 4-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| PPP2R3B protein network | https://string-db.org/network/9606.ENSP00000375080 | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the locali [...] |
| TSSK1B protein network | https://string-db.org/network/9606.ENSP00000375081 | Testis-specific serine/threonine-protein kinase 1; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late st [...] |
| CCL25 protein network | https://string-db.org/network/9606.ENSP00000375086 | C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on [...] |
| TAS2R19 protein network | https://string-db.org/network/9606.ENSP00000375091 | Taste receptor type 2 member 19; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| TAS2R31 protein network | https://string-db.org/network/9606.ENSP00000375093 | Taste receptor type 2 member 31; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| TAS2R13 protein network | https://string-db.org/network/9606.ENSP00000375095 | Taste receptor type 2 member 13; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| KRTAP19-6 protein network | https://string-db.org/network/9606.ENSP00000375107 | Keratin-associated protein 19-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP19-1 protein network | https://string-db.org/network/9606.ENSP00000375108 | Keratin-associated protein 19-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP13-3 protein network | https://string-db.org/network/9606.ENSP00000375109 | Keratin-associated protein 13-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| ZRSR1 protein network | https://string-db.org/network/9606.ENSP00000375133 | U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1 |
| KRTAP16-1 protein network | https://string-db.org/network/9606.ENSP00000375147 | Keratin associated protein 16-1; Belongs to the KRTAP type 16 family |
| KRTAP29-1 protein network | https://string-db.org/network/9606.ENSP00000375148 | Keratin associated protein 29-1; Belongs to the KRTAP type 10 family |
| KRTAP9-7 protein network | https://string-db.org/network/9606.ENSP00000375149 | Keratin-associated protein 9-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP9-6 protein network | https://string-db.org/network/9606.ENSP00000375150 | Keratin-associated protein 9-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP4-3 protein network | https://string-db.org/network/9606.ENSP00000375151 | Keratin-associated protein 4-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| CTAGE1 protein network | https://string-db.org/network/9606.ENSP00000375220 | cTAGE family member 2; Cutaneous T cell lymphoma-associated antigen 1; CTAGE family |
| KRTAP4-11 protein network | https://string-db.org/network/9606.ENSP00000375232 | Keratin-associated protein 4-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP4-9 protein network | https://string-db.org/network/9606.ENSP00000375234 | Keratin-associated protein 4-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP4-7 protein network | https://string-db.org/network/9606.ENSP00000375236 | Keratin associated protein 4-7 |
| KRTAP2-3 protein network | https://string-db.org/network/9606.ENSP00000375237 | Keratin associated protein 2-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP2-1 protein network | https://string-db.org/network/9606.ENSP00000375238 | Keratin-associated protein 2-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| BHLHA9 protein network | https://string-db.org/network/9606.ENSP00000375248 | Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated [...] |
| FAM127B protein network | https://string-db.org/network/9606.ENSP00000375267 | Retrotransposon Gag-like protein 8A; Family with sequence similarity 127, member B; Belongs to the FAM127 family |
| FAM127C protein network | https://string-db.org/network/9606.ENSP00000375268 | Retrotransposon Gag-like protein 8B; Family with sequence similarity 127, member C; Belongs to the FAM127 family |
| PRR33 protein network | https://string-db.org/network/9606.ENSP00000375311 | Proline-rich protein 33; Proline rich 33 |
| OR2A42 protein network | https://string-db.org/network/9606.ENSP00000375334 | Olfactory receptor, family 2, subfamily A, member 42; Odorant receptor; Olfactory receptors, family 2 |
| KRTAP3-3 protein network | https://string-db.org/network/9606.ENSP00000375428 | Keratin-associated protein 3-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP3-2 protein network | https://string-db.org/network/9606.ENSP00000375429 | Keratin-associated protein 3-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP3-1 protein network | https://string-db.org/network/9606.ENSP00000375430 | Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP12-1 protein network | https://string-db.org/network/9606.ENSP00000375475 | Keratin-associated protein 12-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP12-4 protein network | https://string-db.org/network/9606.ENSP00000375476 | Keratin-associated protein 12-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-3 protein network | https://string-db.org/network/9606.ENSP00000375478 | Keratin-associated protein 10-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-2 protein network | https://string-db.org/network/9606.ENSP00000375479 | Keratin-associated protein 10-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP6-3 protein network | https://string-db.org/network/9606.ENSP00000375482 | Keratin-associated protein 6-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| ZNF552 protein network | https://string-db.org/network/9606.ENSP00000375582 | Zinc finger protein 552; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF304 protein network | https://string-db.org/network/9606.ENSP00000375586 | Zinc finger protein 304; Acts as transcriptional regulator and plays a role in gene silencing. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation [...] |
| ZSCAN5A protein network | https://string-db.org/network/9606.ENSP00000375593 | Zinc finger and SCAN domain-containing protein 5A; May be involved in transcriptional regulation; SCAN domain containing |
| KIR3DL1 protein network | https://string-db.org/network/9606.ENSP00000375608 | Killer cell immunoglobulin-like receptor 3DL1; Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis; CD molecules |
| LILRB4 protein network | https://string-db.org/network/9606.ENSP00000375616 | Leukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulati [...] |
| LAIR1 protein network | https://string-db.org/network/9606.ENSP00000375622 | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-c [...] |
| LILRB2 protein network | https://string-db.org/network/9606.ENSP00000375629 | Leukocyte immunoglobulin-like receptor subfamily B member 2; Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulati [...] |
| TFPT protein network | https://string-db.org/network/9606.ENSP00000375639 | TCF3 fusion partner; Appears to promote apoptosis in a p53/TP53-independent manner; INO80 complex |
| CACNG7 protein network | https://string-db.org/network/9606.ENSP00000375647 | Voltage-dependent calcium channel gamma-7 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane a [...] |
| MYADM protein network | https://string-db.org/network/9606.ENSP00000375649 | Myeloid associated differentiation marker; Belongs to the MAL family |
| NLRP12 protein network | https://string-db.org/network/9606.ENSP00000375653 | NACHT, LRR and PYD domains-containing protein 12; May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK; NLR family |
| ZNF321P protein network | https://string-db.org/network/9606.ENSP00000375656 | Putative protein ZNF321; Zinc finger protein 321, pseudogene |
| KLK14 protein network | https://string-db.org/network/9606.ENSP00000375678 | Kallikrein-14; Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and [...] |
| KLK8 protein network | https://string-db.org/network/9606.ENSP00000375682 | Kallikrein-8; Kallikrein related peptidase 8; Kallikreins |
| KLK7 protein network | https://string-db.org/network/9606.ENSP00000375683 | Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino ac [...] |
| AKT1S1 protein network | https://string-db.org/network/9606.ENSP00000375711 | Proline-rich AKT1 substrate 1; Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino [...] |
| PTOV1 protein network | https://string-db.org/network/9606.ENSP00000375717 | Prostate tumor-overexpressed gene 1 protein; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation |
| GNG4 protein network | https://string-db.org/network/9606.ENSP00000375727 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sy [...] |
| RPL13A protein network | https://string-db.org/network/9606.ENSP00000375730 | 60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhi [...] |
| KCNJ14 protein network | https://string-db.org/network/9606.ENSP00000375756 | ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Th [...] |
| CARD8 protein network | https://string-db.org/network/9606.ENSP00000375767 | Caspase recruitment domain-containing protein 8; Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcripti [...] |
| ZNF541 protein network | https://string-db.org/network/9606.ENSP00000375770 | Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis; Myb/SANT domain containing |
| STRN4 protein network | https://string-db.org/network/9606.ENSP00000375777 | Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family |
| LAMB3 protein network | https://string-db.org/network/9606.ENSP00000375778 | Laminin subunit beta-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| DACT3 protein network | https://string-db.org/network/9606.ENSP00000375783 | Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathway [...] |
| IL24 protein network | https://string-db.org/network/9606.ENSP00000375795 | Interleukin-24; Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation; Belongs to the IL-10 family |
| ERCC2 protein network | https://string-db.org/network/9606.ENSP00000375809 | TFIIH basal transcription factor complex helicase XPD subunit; ATP-dependent 5'-3' DNA helicase, component of the core- TFIIH basal transcription factor. Involved in nucleotide excision repair (N [...] |
| KLC3 protein network | https://string-db.org/network/9606.ENSP00000375810 | Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; Belongs to the kinesin light chain family |
| ZNF233 protein network | https://string-db.org/network/9606.ENSP00000375820 | Zinc finger protein 233; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF222 protein network | https://string-db.org/network/9606.ENSP00000375822 | Zinc finger protein 222; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LAD1 protein network | https://string-db.org/network/9606.ENSP00000375829 | Ladinin-1; Anchoring filament protein which is a component of the basement membrane zone |
| HDLBP protein network | https://string-db.org/network/9606.ENSP00000375836 | Vigilin; Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol |
| CAPN10 protein network | https://string-db.org/network/9606.ENSP00000375844 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insuli [...] |
| OTOS protein network | https://string-db.org/network/9606.ENSP00000375849 | Otospiralin; May be essential for the survival of the neurosensory epithelium of the inner ear |
| PDC protein network | https://string-db.org/network/9606.ENSP00000375855 | Phosducin; May participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. Inhibits the transcriptional activation activity of the cone-rod homeob [...] |
| LRRFIP1 protein network | https://string-db.org/network/9606.ENSP00000375857 | Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF [...] |
| TMEM91 protein network | https://string-db.org/network/9606.ENSP00000375859 | Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family |
| HNRNPUL1 protein network | https://string-db.org/network/9606.ENSP00000375863 | Heterogeneous nuclear ribonucleoprotein U-like protein 1; Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated [...] |
| ATG16L1 protein network | https://string-db.org/network/9606.ENSP00000375872 | Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C) [...] |
| ALPP protein network | https://string-db.org/network/9606.ENSP00000375881 | Alkaline phosphatase, placental |
| AKT2 protein network | https://string-db.org/network/9606.ENSP00000375892 | RAC-beta serine/threonine-protein kinase; AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includi [...] |
| GPR55 protein network | https://string-db.org/network/9606.ENSP00000375894 | G-protein coupled receptor 55; May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L- alpha-lysophosphatidylinositol (LPI). LPI induces [...] |
| SP140 protein network | https://string-db.org/network/9606.ENSP00000375899 | Nuclear body protein SP140; Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia [...] |
| LGALS16 protein network | https://string-db.org/network/9606.ENSP00000375904 | Galectin-16; Binds lactose with high affinity. Strong inducer of T- cell apoptosis; Galectins |
| PID1 protein network | https://string-db.org/network/9606.ENSP00000375907 | PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation |
| SPHKAP protein network | https://string-db.org/network/9606.ENSP00000375909 | A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular [...] |
| RHBDD1 protein network | https://string-db.org/network/9606.ENSP00000375914 | Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and ju [...] |
| SAMD4A protein network | https://string-db.org/network/9606.ENSP00000375919 | Protein Smaug homolog 1; Acts as a translational repressor of SRE-containing messengers; Belongs to the SMAUG family |
| PAX3 protein network | https://string-db.org/network/9606.ENSP00000375921 | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, act [...] |
| TBP protein network | https://string-db.org/network/9606.ENSP00000375942 | TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional ste [...] |
| TTLL4 protein network | https://string-db.org/network/9606.ENSP00000375951 | Tubulin polyglutamylase TTLL4; Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS/MB21D1. Involved in the side-chain initiation step [...] |
| MLLT4 protein network | https://string-db.org/network/9606.ENSP00000375960 | Afadin; Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens [...] |
| XRCC5 protein network | https://string-db.org/network/9606.ENSP00000375978 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork- [...] |
| MAP3K4 protein network | https://string-db.org/network/9606.ENSP00000375986 | Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically [...] |
| PNLDC1 protein network | https://string-db.org/network/9606.ENSP00000376007 | Poly(A)-specific ribonuclease PNLDC1; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) t [...] |
| ZNF566 protein network | https://string-db.org/network/9606.ENSP00000376010 | Zinc finger protein 566; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SNX9 protein network | https://string-db.org/network/9606.ENSP00000376024 | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. [...] |
| ZBTB32 protein network | https://string-db.org/network/9606.ENSP00000376035 | Zinc finger and BTB domain-containing protein 32; DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional [...] |
| MAG protein network | https://string-db.org/network/9606.ENSP00000376048 | Myelin-associated glycoprotein; Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoprot [...] |
| EEF1B2 protein network | https://string-db.org/network/9606.ENSP00000376056 | Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP |
| FAM117B protein network | https://string-db.org/network/9606.ENSP00000376071 | Protein FAM117B; Family with sequence similarity 117 member B |
| SUMO1 protein network | https://string-db.org/network/9606.ENSP00000376077 | Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its s [...] |
| URI1 protein network | https://string-db.org/network/9606.ENSP00000376097 | Unconventional prefoldin RPB5 interactor 1; Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) t [...] |
| C19orf12 protein network | https://string-db.org/network/9606.ENSP00000376103 | Protein C19orf12; Chromosome 19 open reading frame 12 |
| ZNF493 protein network | https://string-db.org/network/9606.ENSP00000376110 | Zinc finger protein 493; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SH2D2A protein network | https://string-db.org/network/9606.ENSP00000376123 | SH2 domain-containing protein 2A; Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56- LCK-dependent signal transduction pathwa [...] |
| MYO1B protein network | https://string-db.org/network/9606.ENSP00000376132 | Unconventional myosin-Ib; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport; Myosins, c [...] |
| STAT4 protein network | https://string-db.org/network/9606.ENSP00000376134 | Signal transducer and activator of transcription 4; Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling; SH2 domain containing |
| ZNF605 protein network | https://string-db.org/network/9606.ENSP00000376135 | Zinc finger protein 605; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| WDR45B protein network | https://string-db.org/network/9606.ENSP00000376139 | Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degra [...] |
| MFSD6 protein network | https://string-db.org/network/9606.ENSP00000376141 | Major facilitator superfamily domain containing 6 |
| INPP1 protein network | https://string-db.org/network/9606.ENSP00000376142 | Inositol polyphosphate-1-phosphatase; Belongs to the inositol monophosphatase superfamily |
| GPS1 protein network | https://string-db.org/network/9606.ENSP00000376167 | COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential [...] |
| STRA13 protein network | https://string-db.org/network/9606.ENSP00000376168 | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 comple [...] |
| STX2 protein network | https://string-db.org/network/9606.ENSP00000376178 | Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Syntaxins |
| BDH1 protein network | https://string-db.org/network/9606.ENSP00000376184 | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| CRLF1 protein network | https://string-db.org/network/9606.ENSP00000376188 | Cytokine receptor-like factor 1; Cytokine receptor subunit, possibly playing a regulatory role in the immune system and during fetal development. May be involved in nervous system development; Fi [...] |
| ASH1L protein network | https://string-db.org/network/9606.ENSP00000376204 | Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically methylating 'Lys- 36' of histone H3 (H3K36me); Bromodomain containing |
| KIAA1683 protein network | https://string-db.org/network/9606.ENSP00000376213 | IQ domain-containing protein N; KIAA1683 |
| TMEM200A protein network | https://string-db.org/network/9606.ENSP00000376224 | Transmembrane protein 200A; Belongs to the TMEM200 family |
| TMEM44 protein network | https://string-db.org/network/9606.ENSP00000376227 | Transmembrane protein 44 |
| MB21D2 protein network | https://string-db.org/network/9606.ENSP00000376246 | Protein MB21D2; Mab-21 domain containing 2 |
| CCDC50 protein network | https://string-db.org/network/9606.ENSP00000376250 | Coiled-coil domain-containing protein 50; Involved in EGFR signaling; Deafness associated genes |
| RNF34 protein network | https://string-db.org/network/9606.ENSP00000376258 | E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiqu [...] |
| SEC14L1 protein network | https://string-db.org/network/9606.ENSP00000376268 | SEC14-like protein 1; May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic se [...] |
| NCOA7 protein network | https://string-db.org/network/9606.ENSP00000376269 | Nuclear receptor coactivator 7; Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RA [...] |
| RFC4 protein network | https://string-db.org/network/9606.ENSP00000376272 | Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...] |
| SRSF2 protein network | https://string-db.org/network/9606.ENSP00000376276 | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal compone [...] |
| LENEP protein network | https://string-db.org/network/9606.ENSP00000376278 | Lens epithelial cell protein LEP503; May play a role in lens epithelial cell differentiation |
| CRYGS protein network | https://string-db.org/network/9606.ENSP00000376287 | Beta-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| OSBPL6 protein network | https://string-db.org/network/9606.ENSP00000376293 | Oxysterol-binding protein-related protein 6; Weakly binds 25-hydroxycholesterol; Belongs to the OSBP family |
| DYNLL1 protein network | https://string-db.org/network/9606.ENSP00000376297 | Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to [...] |
| CPT1C protein network | https://string-db.org/network/9606.ENSP00000376303 | Carnitine O-palmitoyltransferase 1, brain isoform; May play a role in lipid metabolic process; Belongs to the carnitine/choline acetyltransferase family |
| TMEM121 protein network | https://string-db.org/network/9606.ENSP00000376304 | Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family |
| CIT protein network | https://string-db.org/network/9606.ENSP00000376306 | Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO [...] |
| C14orf80 protein network | https://string-db.org/network/9606.ENSP00000376307 | Uncharacterized protein C14orf80; Chromosome 14 open reading frame 80 |
| HNRNPA3 protein network | https://string-db.org/network/9606.ENSP00000376309 | Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing; RNA binding motif [...] |
| TAOK3 protein network | https://string-db.org/network/9606.ENSP00000376317 | Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator o [...] |
| HOXD13 protein network | https://string-db.org/network/9606.ENSP00000376322 | Homeobox protein Hox-D13; Sequence-specific transcription factor that binds gene promoters and activates their transcription. Part of a developmental regulatory system that provides cells with sp [...] |
| WIPF1 protein network | https://string-db.org/network/9606.ENSP00000376330 | WAS/WASL-interacting protein family member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participa [...] |
| LLGL2 protein network | https://string-db.org/network/9606.ENSP00000376333 | Lethal(2) giant larvae protein homolog 2; Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal c [...] |
| GPR155 protein network | https://string-db.org/network/9606.ENSP00000376335 | Integral membrane protein GPR155; G protein-coupled receptor 155 |
| BTBD6 protein network | https://string-db.org/network/9606.ENSP00000376337 | BTB/POZ domain-containing protein 6; Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity); [...] |
| GRB2 protein network | https://string-db.org/network/9606.ENSP00000376345 | Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; SH2 domain containing |
| NUDT14 protein network | https://string-db.org/network/9606.ENSP00000376349 | Uridine diphosphate glucose pyrophosphatase; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucos [...] |
| PDK1 protein network | https://string-db.org/network/9606.ENSP00000376352 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation [...] |
| WASF1 protein network | https://string-db.org/network/9606.ENSP00000376368 | Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...] |
| PLD4 protein network | https://string-db.org/network/9606.ENSP00000376372 | Phospholipase D family member 4; Belongs to the phospholipase D family |
| GPR123 protein network | https://string-db.org/network/9606.ENSP00000376384 | Adhesion G protein-coupled receptor A1; Orphan receptor |
| RAB37 protein network | https://string-db.org/network/9606.ENSP00000376390 | Ras-related protein Rab-37; RAB37, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family |
| CD300E protein network | https://string-db.org/network/9606.ENSP00000376395 | CMRF35-like molecule 2; Probably acts as an activating receptor; CD molecules |
| CD300LB protein network | https://string-db.org/network/9606.ENSP00000376397 | CMRF35-like molecule 7; Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2; V-set domain containing |
| GPRC5C protein network | https://string-db.org/network/9606.ENSP00000376403 | G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling [...] |
| INF2 protein network | https://string-db.org/network/9606.ENSP00000376410 | Inverted formin-2; Severs actin filaments and accelerates their polymerization and depolymerization; Armadillo-like helical domain containing |
| ARMC2 protein network | https://string-db.org/network/9606.ENSP00000376417 | Required for sperm flagellum axoneme organization and function (By similarity). Involved in axonemal central pair complex assembly and/or stability (By similarity). |
| KLHL23 protein network | https://string-db.org/network/9606.ENSP00000376419 | Kelch-like protein 23; Kelch like family member 23; BTB domain containing |
| SDK2 protein network | https://string-db.org/network/9606.ENSP00000376421 | Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts [...] |
| SPRR2A protein network | https://string-db.org/network/9606.ENSP00000376423 | Small proline-rich protein 2A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| KCNJ1 protein network | https://string-db.org/network/9606.ENSP00000376432 | ATP-sensitive inward rectifier potassium channel 1; In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendenc [...] |
| ETS1 protein network | https://string-db.org/network/9606.ENSP00000376436 | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival [...] |
| RAD9B protein network | https://string-db.org/network/9606.ENSP00000376440 | Cell cycle checkpoint control protein RAD9B; RAD9 checkpoint clamp component B |
| ABCA5 protein network | https://string-db.org/network/9606.ENSP00000376443 | ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes; Belongs to the ABC transporter superfamily. ABCA family |
| TIRAP protein network | https://string-db.org/network/9606.ENSP00000376445 | Toll/interleukin-1 receptor domain-containing adapter protein; Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activa [...] |
| CERS6 protein network | https://string-db.org/network/9606.ENSP00000376453 | Ceramide synthase 6; May be involved in sphingolipid synthesis or its regulation; CERS class homeoboxes |
| B3GALT1 protein network | https://string-db.org/network/9606.ENSP00000376456 | Beta-1,3-galactosyltransferase 1; Beta-1,3-galactosyltransferase that transfers galactose from UDP-alpha-D-galactose to substrates with a terminal beta-N- acetylglucosamine (beta-GlcNAc) residue. [...] |
| ECT2 protein network | https://string-db.org/network/9606.ENSP00000376457 | Protein ECT2; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC [...] |
| CDON protein network | https://string-db.org/network/9606.ENSP00000376458 | Cell adhesion molecule-related/down-regulated by oncogenes; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiat [...] |
| GALNT3 protein network | https://string-db.org/network/9606.ENSP00000376465 | Polypeptide N-acetylgalactosaminyltransferase 3; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| STT3A protein network | https://string-db.org/network/9606.ENSP00000376472 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose ol [...] |
| PRKAR1A protein network | https://string-db.org/network/9606.ENSP00000376475 | cAMP-dependent protein kinase type I-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells |
| TANK protein network | https://string-db.org/network/9606.ENSP00000376505 | TRAF family member-associated NF-kappa-B activator; Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immu [...] |
| PDCD10 protein network | https://string-db.org/network/9606.ENSP00000376506 | Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, [...] |
| CEP112 protein network | https://string-db.org/network/9606.ENSP00000376522 | Centrosomal protein 112 |
| SCN3B protein network | https://string-db.org/network/9606.ENSP00000376523 | Sodium channel subunit beta-3; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its associa [...] |
| B3GALNT1 protein network | https://string-db.org/network/9606.ENSP00000376532 | UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine onto globotriaosylceramide; Belongs to the glycosyltransferase 31 family |
| BAZ2B protein network | https://string-db.org/network/9606.ENSP00000376534 | Bromodomain adjacent to zinc finger domain protein 2B; May play a role in transcriptional regulation interacting with ISWI; Belongs to the WAL family |
| TECTA protein network | https://string-db.org/network/9606.ENSP00000376543 | Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepit [...] |
| CD79B protein network | https://string-db.org/network/9606.ENSP00000376544 | B-cell antigen receptor complex-associated protein beta chain; Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor comple [...] |
| TMEM119 protein network | https://string-db.org/network/9606.ENSP00000376553 | Transmembrane protein 119; Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and diff [...] |
| TMUB1 protein network | https://string-db.org/network/9606.ENSP00000376565 | Transmembrane and ubiquitin-like domain-containing protein 1; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selec [...] |
| MLF1 protein network | https://string-db.org/network/9606.ENSP00000376568 | Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-ind [...] |
| GALNT13 protein network | https://string-db.org/network/9606.ENSP00000376570 | Polypeptide N-acetylgalactosaminyltransferase 13; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or thre [...] |
| RNF208 protein network | https://string-db.org/network/9606.ENSP00000376572 | Ring finger protein 208 |
| RIC8B protein network | https://string-db.org/network/9606.ENSP00000376583 | Synembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP [...] |
| SLC33A1 protein network | https://string-db.org/network/9606.ENSP00000376587 | Acetyl-coenzyme A transporter 1; Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides. Negatively regulates BMP signaling; Solute carriers |
| SMIM8 protein network | https://string-db.org/network/9606.ENSP00000376603 | Small integral membrane protein 8 |
| GTDC1 protein network | https://string-db.org/network/9606.ENSP00000376608 | Glycosyltransferase-like domain-containing protein 1; Glycosyl transferases group 1 domain containing; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily |
| GRK5 protein network | https://string-db.org/network/9606.ENSP00000376609 | G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphoryla [...] |
| TDG protein network | https://string-db.org/network/9606.ENSP00000376611 | G/T mismatch-specific thymine DNA glycosylase; DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine ( [...] |
| NT5DC3 protein network | https://string-db.org/network/9606.ENSP00000376615 | 5'-nucleotidase domain containing 3 |
| CSH2 protein network | https://string-db.org/network/9606.ENSP00000376623 | Chorionic somatomammotropin hormone 2; Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR thr [...] |
| EVL protein network | https://string-db.org/network/9606.ENSP00000376652 | Ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipod [...] |
| SYCP3 protein network | https://string-db.org/network/9606.ENSP00000376658 | Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in mal [...] |
| LCA5 protein network | https://string-db.org/network/9606.ENSP00000376686 | Lebercilin; Might be involved in minus end-directed microtubule transport |
| CYB561 protein network | https://string-db.org/network/9606.ENSP00000376702 | Cytochrome b561; Secretory vesicle-specific electron transport protein; Cytochrome b561 |
| ANO4 protein network | https://string-db.org/network/9606.ENSP00000376703 | Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel [...] |
| VWA2 protein network | https://string-db.org/network/9606.ENSP00000376708 | Von Willebrand factor A domain containing 2 |
| MRPS33 protein network | https://string-db.org/network/9606.ENSP00000376732 | Mitochondrial ribosomal protein S33; Belongs to the mitochondrion-specific ribosomal protein mS33 family |
| GIPC1 protein network | https://string-db.org/network/9606.ENSP00000376753 | PDZ domain-containing protein GIPC1; May be involved in G protein-linked signaling; Belongs to the GIPC family |
| PIAS3 protein network | https://string-db.org/network/9606.ENSP00000376765 | E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...] |
| C11orf57 protein network | https://string-db.org/network/9606.ENSP00000376767 | Uncharacterized protein NKAPD1; Chromosome 11 open reading frame 57 |
| DBH protein network | https://string-db.org/network/9606.ENSP00000376776 | Dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline |
| POU2AF1 protein network | https://string-db.org/network/9606.ENSP00000376786 | POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, t [...] |
| VTI1A protein network | https://string-db.org/network/9606.ENSP00000376792 | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are [...] |
| GIG25 protein network | https://string-db.org/network/9606.ENSP00000376793 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, b [...] |
| MTPN protein network | https://string-db.org/network/9606.ENSP00000376800 | Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity (By similarity). Plays a role in the regulation of the growth of actin filaments. I [...] |
| DPEP1 protein network | https://string-db.org/network/9606.ENSP00000376807 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important rol [...] |
| CUL5 protein network | https://string-db.org/network/9606.ENSP00000376808 | Cullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradat [...] |
| STEAP3 protein network | https://string-db.org/network/9606.ENSP00000376822 | Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe( [...] |
| C7orf49 protein network | https://string-db.org/network/9606.ENSP00000376823 | Cell cycle regulator of non-homologous end joining; Isoform 1: Cell-cycle-specific inhibitor of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair during the S an [...] |
| MKS1 protein network | https://string-db.org/network/9606.ENSP00000376827 | Meckel syndrome type 1 protein; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembran [...] |
| BPGM protein network | https://string-db.org/network/9606.ENSP00000376840 | Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits muta [...] |
| PRIMA1 protein network | https://string-db.org/network/9606.ENSP00000376848 | Proline-rich membrane anchor 1; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to or [...] |
| CASP5 protein network | https://string-db.org/network/9606.ENSP00000376849 | Caspase-5; Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts MB21D1 and may play a role in the regulation of antiviral innate immune activation; Ca [...] |
| DPP10 protein network | https://string-db.org/network/9606.ENSP00000376855 | Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipepti [...] |
| PDGFD protein network | https://string-db.org/network/9606.ENSP00000376865 | Platelet-derived growth factor D; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitoge [...] |
| RABL2A protein network | https://string-db.org/network/9606.ENSP00000376872 | Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins inclu [...] |
| NME1-NME2 protein network | https://string-db.org/network/9606.ENSP00000376886 | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-s [...] |
| NME2 protein network | https://string-db.org/network/9606.ENSP00000376889 | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional [...] |
| IL1F10 protein network | https://string-db.org/network/9606.ENSP00000376893 | Interleukin-1 family member 10; Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Ca [...] |
| IL36RN protein network | https://string-db.org/network/9606.ENSP00000376896 | Interleukin-36 receptor antagonist protein; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP [...] |
| PTGFRN protein network | https://string-db.org/network/9606.ENSP00000376899 | Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity [...] |
| BANP protein network | https://string-db.org/network/9606.ENSP00000376902 | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an AT [...] |
| LRRIQ1 protein network | https://string-db.org/network/9606.ENSP00000376910 | Leucine rich repeats and IQ motif containing 1 |
| LGMN protein network | https://string-db.org/network/9606.ENSP00000376911 | Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradatio [...] |
| NTNG2 protein network | https://string-db.org/network/9606.ENSP00000376921 | Netrin-G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites; Net [...] |
| NRF1 protein network | https://string-db.org/network/9606.ENSP00000376924 | Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth an [...] |
| TMCC1 protein network | https://string-db.org/network/9606.ENSP00000376930 | Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission . Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by pro [...] |
| BCL2L11 protein network | https://string-db.org/network/9606.ENSP00000376943 | Bcl-2-like protein 11; Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less [...] |
| FBXW9 protein network | https://string-db.org/network/9606.ENSP00000376945 | F-box/WD repeat-containing protein 9; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing |
| BBS10 protein network | https://string-db.org/network/9606.ENSP00000376946 | Bardet-Biedl syndrome 10 protein; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a co [...] |
| EME1 protein network | https://string-db.org/network/9606.ENSP00000376952 | Crossover junction endonuclease EME1; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Ty [...] |
| DENND2C protein network | https://string-db.org/network/9606.ENSP00000376955 | DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins int [...] |
| ZNF800 protein network | https://string-db.org/network/9606.ENSP00000376989 | Zinc finger protein 800; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| BCL2L15 protein network | https://string-db.org/network/9606.ENSP00000376992 | Bcl-2-like protein 15; BCL2 like 15 |
| SPOP protein network | https://string-db.org/network/9606.ENSP00000377001 | Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their [...] |
| TSPAN8 protein network | https://string-db.org/network/9606.ENSP00000377003 | Tetraspanin-8; Tetraspanin 8; Belongs to the tetraspanin (TM4SF) family |
| CENPN protein network | https://string-db.org/network/9606.ENSP00000377007 | Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| PICALM protein network | https://string-db.org/network/9606.ENSP00000377015 | Phosphatidylinositol-binding clathrin assembly protein; Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-ve [...] |
| CNOT6 protein network | https://string-db.org/network/9606.ENSP00000377024 | CCR4-NOT transcription complex subunit 6; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linke [...] |
| TGFBRAP1 protein network | https://string-db.org/network/9606.ENSP00000377027 | Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor comple [...] |
| ATP5G1 protein network | https://string-db.org/network/9606.ENSP00000377033 | ATP synthase F(0) complex subunit C1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...] |
| PPP2R4 protein network | https://string-db.org/network/9606.ENSP00000377036 | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a [...] |
| RASGEF1C protein network | https://string-db.org/network/9606.ENSP00000377037 | Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF) |
| AASS protein network | https://string-db.org/network/9606.ENSP00000377040 | Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarat [...] |
| TTLL6 protein network | https://string-db.org/network/9606.ENSP00000377043 | Tubulin polyglutamylase TTLL6; Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglu [...] |
| PTPRZ1 protein network | https://string-db.org/network/9606.ENSP00000377047 | Receptor-type tyrosine-protein phosphatase zeta; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal d [...] |
| ANKRD42 protein network | https://string-db.org/network/9606.ENSP00000377051 | Ankyrin repeat domain-containing protein 42; Protein phosphatase 1 regulatory subunits; Ankyrin repeat domain containing |
| PRCP protein network | https://string-db.org/network/9606.ENSP00000377055 | Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymati [...] |
| SNX11 protein network | https://string-db.org/network/9606.ENSP00000377059 | Sorting nexin-11; Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes; Belongs to the sorting nexin family |
| CBX1 protein network | https://string-db.org/network/9606.ENSP00000377060 | Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) c [...] |
| PLXNA1 protein network | https://string-db.org/network/9606.ENSP00000377061 | Plexin-A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive [...] |
| RGL3 protein network | https://string-db.org/network/9606.ENSP00000377075 | Ral guanine nucleotide dissociation stimulator-like 3; Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates El [...] |
| ZFP1 protein network | https://string-db.org/network/9606.ENSP00000377080 | Zinc finger protein 1 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| LONRF2 protein network | https://string-db.org/network/9606.ENSP00000377086 | LON peptidase N-terminal domain and ring finger 2 |
| SLC12A8 protein network | https://string-db.org/network/9606.ENSP00000377112 | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation; Solute carriers |
| LIPT1 protein network | https://string-db.org/network/9606.ENSP00000377115 | Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes; Belongs to the LplA [...] |
| TSGA10 protein network | https://string-db.org/network/9606.ENSP00000377123 | Testis-specific gene 10 protein; May play a role in the sperm tail fibrous sheath, a major sperm tail structure; Belongs to the CEP135/TSGA10 family |
| CNGA3 protein network | https://string-db.org/network/9606.ENSP00000377140 | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP w [...] |
| AP1G1 protein network | https://string-db.org/network/9606.ENSP00000377148 | AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...] |
| ANKRD39 protein network | https://string-db.org/network/9606.ENSP00000377170 | Ankyrin repeat domain-containing protein 39; Ankyrin repeat domain containing; Belongs to the ANKRD39 family |
| ZNF359 protein network | https://string-db.org/network/9606.ENSP00000377171 | Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SPATA7 protein network | https://string-db.org/network/9606.ENSP00000377176 | Spermatogenesis-associated protein 7; Involved in photoreceptor cells maintenance (By similarity). It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connectin [...] |
| G6PD protein network | https://string-db.org/network/9606.ENSP00000377192 | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysi [...] |
| HYDIN protein network | https://string-db.org/network/9606.ENSP00000377197 | Hydrocephalus-inducing protein homolog; Required for ciliary motility; Protein phosphatase 1 regulatory subunits |
| IRF2 protein network | https://string-db.org/network/9606.ENSP00000377218 | Interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses thos [...] |
| CDKN2D protein network | https://string-db.org/network/9606.ENSP00000377224 | Cyclin-dependent kinase 4 inhibitor D; Interacts strongly with CDK4 and CDK6 and inhibits them; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family |
| FAM50A protein network | https://string-db.org/network/9606.ENSP00000377225 | Protein FAM50A; May be a DNA-binding protein or transcriptional factor; Spliceosomal C complex |
| ARAP1 protein network | https://string-db.org/network/9606.ENSP00000377233 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeli [...] |
| MON2 protein network | https://string-db.org/network/9606.ENSP00000377250 | Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Armadillo-like helical domain containing |
| ST3GAL2 protein network | https://string-db.org/network/9606.ENSP00000377257 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Responsible for the synthesis of the sequence NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups [...] |
| SRPK2 protein network | https://string-db.org/network/9606.ENSP00000377262 | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, know [...] |
| TFAP2B protein network | https://string-db.org/network/9606.ENSP00000377265 | Transcription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors [...] |
| GOLGB1 protein network | https://string-db.org/network/9606.ENSP00000377275 | Golgin subfamily B member 1; May participate in forming intercisternal cross-bridges of the Golgi complex |
| FBXO8 protein network | https://string-db.org/network/9606.ENSP00000377280 | F-box only protein 8; May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential); F-boxes other |
| ZFYVE27 protein network | https://string-db.org/network/9606.ENSP00000377282 | Protrudin; Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport. Promotes axonal elongation and contributes to the establishment of [...] |
| FOLR1 protein network | https://string-db.org/network/9606.ENSP00000377284 | Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for fo [...] |
| NUMA1 protein network | https://string-db.org/network/9606.ENSP00000377298 | Nuclear mitotic apparatus protein 1; Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes [...] |
| RENBP protein network | https://string-db.org/network/9606.ENSP00000377303 | N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and i [...] |
| FDX1L protein network | https://string-db.org/network/9606.ENSP00000377311 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis; Belongs to the adrenodoxin/putidaredoxin family |
| DDX60 protein network | https://string-db.org/network/9606.ENSP00000377344 | Probable ATP-dependent RNA helicase DDX60; Positively regulates DDX58/RIG-I- and IFIH1/MDA5- dependent type I interferon and interferon inducible gene expression in response to viral infection. B [...] |
| DRD1 protein network | https://string-db.org/network/9606.ENSP00000377353 | D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family |
| ZDHHC16 protein network | https://string-db.org/network/9606.ENSP00000377357 | Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly [...] |
| LRRC74A protein network | https://string-db.org/network/9606.ENSP00000377369 | Leucine-rich repeat-containing protein 74A; Leucine rich repeat containing 74A |
| IGSF11 protein network | https://string-db.org/network/9606.ENSP00000377370 | Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth; I-set domain containing |
| GAP43 protein network | https://string-db.org/network/9606.ENSP00000377372 | Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filop [...] |
| ERGIC1 protein network | https://string-db.org/network/9606.ENSP00000377374 | Endoplasmic reticulum-Golgi intermediate compartment protein 1; Possible role in transport between endoplasmic reticulum and Golgi |
| ARHGAP9 protein network | https://string-db.org/network/9606.ENSP00000377380 | Rho GTPase-activating protein 9; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has a substantial GAP activity toward CDC42 and RAC1 and less toward [...] |
| UBTD2 protein network | https://string-db.org/network/9606.ENSP00000377381 | Ubiquitin domain containing 2 |
| PSMC3IP protein network | https://string-db.org/network/9606.ENSP00000377384 | Homologous-pairing protein 2 homolog; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The co [...] |
| PPAN-P2RY11 protein network | https://string-db.org/network/9606.ENSP00000377385 | PPAN-P2RY11 readthrough; Belongs to the G-protein coupled receptor 1 family |
| PPP6R3 protein network | https://string-db.org/network/9606.ENSP00000377390 | Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintainin [...] |
| FAM198B protein network | https://string-db.org/network/9606.ENSP00000377396 | Protein FAM198B; Family with sequence similarity 198 member B; Belongs to the FAM198 family |
| SLC35B2 protein network | https://string-db.org/network/9606.ENSP00000377401 | Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sul [...] |
| NDUFA4L2 protein network | https://string-db.org/network/9606.ENSP00000377411 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; NDUFA4, mitochondrial complex associated like 2 |
| SLC29A1 protein network | https://string-db.org/network/9606.ENSP00000377424 | Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor [...] |
| CFAP44 protein network | https://string-db.org/network/9606.ENSP00000377428 | Cilia and flagella associated protein 44; Belongs to the CFAP44 family |
| SUCLG1 protein network | https://string-db.org/network/9606.ENSP00000377446 | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of [...] |
| REG3A protein network | https://string-db.org/network/9606.ENSP00000377456 | Regenerating islet-derived protein 3-alpha; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydr [...] |
| CNP protein network | https://string-db.org/network/9606.ENSP00000377470 | 2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin |
| CORO1B protein network | https://string-db.org/network/9606.ENSP00000377471 | Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity); Coronins |
| MAGEA12 protein network | https://string-db.org/network/9606.ENSP00000377478 | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines; MAGE family |
| MRPL19 protein network | https://string-db.org/network/9606.ENSP00000377486 | Mitochondrial ribosomal protein L19; Belongs to the bacterial ribosomal protein bL19 family |
| HMMR protein network | https://string-db.org/network/9606.ENSP00000377492 | Hyaluronan mediated motility receptor; Receptor for hyaluronic acid (HA) (By similarity). Involved in cell motility (By similarity). When hyaluronan binds to HMMR, the phosphorylation of a number [...] |
| TAGLN3 protein network | https://string-db.org/network/9606.ENSP00000377494 | Transgelin-3; Transgelin 3 |
| ZNF414 protein network | https://string-db.org/network/9606.ENSP00000377504 | Zinc finger protein 414; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| JUP protein network | https://string-db.org/network/9606.ENSP00000377508 | Junction plakoglobin; Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of [...] |
| SYT12 protein network | https://string-db.org/network/9606.ENSP00000377520 | Synaptotagmin-12; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ve [...] |
| MOSPD3 protein network | https://string-db.org/network/9606.ENSP00000377522 | Motile sperm domain containing 3 |
| PC protein network | https://string-db.org/network/9606.ENSP00000377532 | Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transf [...] |
| PTTG1 protein network | https://string-db.org/network/9606.ENSP00000377536 | Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, [...] |
| C1QTNF2 protein network | https://string-db.org/network/9606.ENSP00000377545 | Complement C1q tumor necrosis factor-related protein 2; C1q and TNF related 2 |
| CCNJL protein network | https://string-db.org/network/9606.ENSP00000377547 | Cyclin-J-like protein; Cyclin J like; Cyclins |
| FABP6 protein network | https://string-db.org/network/9606.ENSP00000377549 | Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By s [...] |
| KRT35 protein network | https://string-db.org/network/9606.ENSP00000377558 | Keratin, type I cuticular Ha5; Keratins, type I |
| ELMO3 protein network | https://string-db.org/network/9606.ENSP00000377566 | Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initial [...] |
| KRT34 protein network | https://string-db.org/network/9606.ENSP00000377570 | Keratin, type I cuticular Ha4; Keratins, type I |
| KRTAP9-9 protein network | https://string-db.org/network/9606.ENSP00000377576 | Keratin associated protein 9-9 |
| CCDC176 protein network | https://string-db.org/network/9606.ENSP00000377577 | Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabili [...] |
| KRTAP4-12 protein network | https://string-db.org/network/9606.ENSP00000377582 | Keratin-associated protein 4-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP2-4 protein network | https://string-db.org/network/9606.ENSP00000377583 | annotation not available |
| HELLS protein network | https://string-db.org/network/9606.ENSP00000377601 | Lymphoid-specific helicase; Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance [...] |
| KRT222 protein network | https://string-db.org/network/9606.ENSP00000377616 | Keratin-like protein KRT222; Keratins, type II |
| MTHFD2 protein network | https://string-db.org/network/9606.ENSP00000377617 | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency; Belongs [...] |
| STAMBP protein network | https://string-db.org/network/9606.ENSP00000377633 | STAM-binding protein; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity). Plays a role in s [...] |
| RPL24 protein network | https://string-db.org/network/9606.ENSP00000377640 | Ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family |
| SENP7 protein network | https://string-db.org/network/9606.ENSP00000377655 | Sentrin-specific protease 7; Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low effici [...] |
| GAPVD1 protein network | https://string-db.org/network/9606.ENSP00000377664 | GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processe [...] |
| SUOX protein network | https://string-db.org/network/9606.ENSP00000377668 | Sulfite oxidase, mitochondrial; Sulfite oxidase |
| G3BP1 protein network | https://string-db.org/network/9606.ENSP00000377681 | Ras GTPase-activating protein-binding protein 1; May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively [...] |
| MED24 protein network | https://string-db.org/network/9606.ENSP00000377686 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| TTC23 protein network | https://string-db.org/network/9606.ENSP00000377690 | Participates positively in the ciliary Hedgehog (Hh) signaling |
| NIT2 protein network | https://string-db.org/network/9606.ENSP00000377696 | Omega-amidase NIT2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologic [...] |
| GPR112 protein network | https://string-db.org/network/9606.ENSP00000377699 | Adhesion G-protein coupled receptor G4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily |
| TBC1D23 protein network | https://string-db.org/network/9606.ENSP00000377700 | TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Plays a role in brain development, including in cortical neuron positioning (By s [...] |
| ZSCAN25 protein network | https://string-db.org/network/9606.ENSP00000377708 | Zinc finger and SCAN domain-containing protein 25; May be involved in transcriptional regulation; SCAN domain containing |
| FHL1 protein network | https://string-db.org/network/9606.ENSP00000377710 | Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy; LIM domain containing |
| NR2F2 protein network | https://string-db.org/network/9606.ENSP00000377721 | COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or prog [...] |
| ORMDL3 protein network | https://string-db.org/network/9606.ENSP00000377724 | ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling; Belongs to the ORM family |
| ZKSCAN5 protein network | https://string-db.org/network/9606.ENSP00000377725 | Zinc finger protein with KRAB and SCAN domains 5; May be involved in transcriptional regulation; SCAN domain containing |
| CHD2 protein network | https://string-db.org/network/9606.ENSP00000377747 | Chromodomain-helicase-DNA-binding protein 2; DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of his [...] |
| DHFRL1 protein network | https://string-db.org/network/9606.ENSP00000377768 | Dihydrofolate reductase 2, mitochondrial; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mt [...] |
| ARL13B protein network | https://string-db.org/network/9606.ENSP00000377769 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcompl [...] |
| SIPA1 protein network | https://string-db.org/network/9606.ENSP00000377771 | Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound st [...] |
| MIEN1 protein network | https://string-db.org/network/9606.ENSP00000377778 | Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through contr [...] |
| SV2B protein network | https://string-db.org/network/9606.ENSP00000377779 | Synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells |
| ELF2 protein network | https://string-db.org/network/9606.ENSP00000377782 | ETS-related transcription factor Elf-2; Isoform 1 transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter; ETS transcription fa [...] |
| PROS1 protein network | https://string-db.org/network/9606.ENSP00000377783 | Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and st [...] |
| GUCA1A protein network | https://string-db.org/network/9606.ENSP00000377784 | Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevat [...] |
| SYNPO protein network | https://string-db.org/network/9606.ENSP00000377789 | Synaptopodin; Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the forma [...] |
| PRC1 protein network | https://string-db.org/network/9606.ENSP00000377793 | Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formatio [...] |
| METTL7B protein network | https://string-db.org/network/9606.ENSP00000377796 | Methyltransferase-like protein 7B; Probable methyltransferase |
| USP49 protein network | https://string-db.org/network/9606.ENSP00000377797 | Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a re [...] |
| OR6C4 protein network | https://string-db.org/network/9606.ENSP00000377799 | Olfactory receptor 6C4; Odorant receptor; Olfactory receptors, family 6 |
| RCCD1 protein network | https://string-db.org/network/9606.ENSP00000377801 | RCC1 domain-containing protein 1; Acts as a coregulator of KDM8 to promote histone demethylase activity on di- and trimethylated 'Lys-36' (H3K36me2/me3) of histone H3. Plays a role in transcripti [...] |
| OEBT protein network | https://string-db.org/network/9606.ENSP00000377806 | Prickle planar cell polarity protein 4; Belongs to the prickle / espinas / testin family |
| FAM122A protein network | https://string-db.org/network/9606.ENSP00000377807 | Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subuni [...] |
| HDDC3 protein network | https://string-db.org/network/9606.ENSP00000377814 | Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response |
| NDRG4 protein network | https://string-db.org/network/9606.ENSP00000377823 | Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell [...] |
| ANXA4 protein network | https://string-db.org/network/9606.ENSP00000377833 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Annexins |
| GPC3 protein network | https://string-db.org/network/9606.ENSP00000377836 | Glypican-3; Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly [...] |
| CACNB1 protein network | https://string-db.org/network/9606.ENSP00000377840 | Voltage-dependent L-type calcium channel subunit beta-1; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...] |
| LHX6 protein network | https://string-db.org/network/9606.ENSP00000377854 | LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cor [...] |
| FAT4 protein network | https://string-db.org/network/9606.ENSP00000377862 | Protocadherin Fat 4; Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor [...] |
| MST4 protein network | https://string-db.org/network/9606.ENSP00000377867 | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activatio [...] |
| ATP5G2 protein network | https://string-db.org/network/9606.ENSP00000377878 | ATP synthase F(0) complex subunit C2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the [...] |
| FBXO38 protein network | https://string-db.org/network/9606.ENSP00000377895 | F-box only protein 38; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiq [...] |
| LIPF protein network | https://string-db.org/network/9606.ENSP00000377900 | Lipase F, gastric type; Lipases |
| CIAPIN1 protein network | https://string-db.org/network/9606.ENSP00000377914 | Anamorsin; Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). Component of t [...] |
| KIF7 protein network | https://string-db.org/network/9606.ENSP00000377934 | Kinesin-like protein KIF7; Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstrea [...] |
| PPP2R2B protein network | https://string-db.org/network/9606.ENSP00000377936 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the l [...] |
| ACTN1 protein network | https://string-db.org/network/9606.ENSP00000377941 | Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Belongs to the alpha-actinin family |
| UTP14A protein network | https://string-db.org/network/9606.ENSP00000377944 | U3 small nucleolar RNA-associated protein 14 homolog A; May be required for ribosome biogenesis |
| QRFPR protein network | https://string-db.org/network/9606.ENSP00000377948 | Pyroglutamylated RFamide peptide receptor; Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intr [...] |
| LARS protein network | https://string-db.org/network/9606.ENSP00000377954 | Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and [...] |
| CCT4 protein network | https://string-db.org/network/9606.ENSP00000377958 | T-complex protein 1 subunit delta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex in [...] |
| GTF2F1 protein network | https://string-db.org/network/9606.ENSP00000377969 | General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration w [...] |
| AHSA2 protein network | https://string-db.org/network/9606.ENSP00000377970 | Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity |
| ANKLE1 protein network | https://string-db.org/network/9606.ENSP00000377971 | Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair; Ankyrin repeat domain containing |
| MT1X protein network | https://string-db.org/network/9606.ENSP00000377995 | Metallothionein-1X; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| KRIT1 protein network | https://string-db.org/network/9606.ENSP00000378015 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity (By similarity). Negative regulator of angiogen [...] |
| RNF14 protein network | https://string-db.org/network/9606.ENSP00000378028 | E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which co [...] |
| BAD protein network | https://string-db.org/network/9606.ENSP00000378040 | Bcl2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins [...] |
| FKBP2 protein network | https://string-db.org/network/9606.ENSP00000378046 | Peptidyl-prolyl cis-trans isomerase FKBP2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; FKBP prolyl isome [...] |
| TRPT1 protein network | https://string-db.org/network/9606.ENSP00000378050 | tRNA 2'-phosphotransferase 1; Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate; B [...] |
| DNASE1L3 protein network | https://string-db.org/network/9606.ENSP00000378053 | Deoxyribonuclease gamma; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to [...] |
| EFEMP1 protein network | https://string-db.org/network/9606.ENSP00000378058 | EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in [...] |
| SLFN12 protein network | https://string-db.org/network/9606.ENSP00000378063 | Schlafen family member 12; Belongs to the Schlafen family |
| SLFN11 protein network | https://string-db.org/network/9606.ENSP00000378067 | Schlafen family member 11; Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as hum [...] |
| PNPLA1 protein network | https://string-db.org/network/9606.ENSP00000378072 | Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism; Patatin like ph [...] |
| SLC28A1 protein network | https://string-db.org/network/9606.ENSP00000378074 | Sodium/nucleoside cotransporter 1; Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for p [...] |
| PCDHGA2 protein network | https://string-db.org/network/9606.ENSP00000378077 | Protocadherin gamma-A2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| NMB protein network | https://string-db.org/network/9606.ENSP00000378089 | Neuromedin-B; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family |
| ELOVL6 protein network | https://string-db.org/network/9606.ENSP00000378105 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| CCL8 protein network | https://string-db.org/network/9606.ENSP00000378118 | C-C motif chemokine 8; Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. May play a role in neoplasia and inflammatory host responses. This protein can bind hepa [...] |
| STEAP2 protein network | https://string-db.org/network/9606.ENSP00000378119 | Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity); STEAP family |
| CFI protein network | https://string-db.org/network/9606.ENSP00000378130 | Complement factor I; Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively; Belongs to the peptidase S1 family |
| IRX5 protein network | https://string-db.org/network/9606.ENSP00000378132 | Iroquois-class homeodomain protein IRX-5; Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell dif [...] |
| CCDC109B protein network | https://string-db.org/network/9606.ENSP00000378145 | Calcium uniporter regulatory subunit MCUb, mitochondrial; Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into t [...] |
| AKTIP protein network | https://string-db.org/network/9606.ENSP00000378152 | AKT-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sortin [...] |
| ACYP2 protein network | https://string-db.org/network/9606.ENSP00000378161 | Acylphosphatase-2; Its physiological role is not yet clear |
| RPL34 protein network | https://string-db.org/network/9606.ENSP00000378163 | 60S ribosomal protein L34; Component of the large ribosomal subunit |
| ZNF207 protein network | https://string-db.org/network/9606.ENSP00000378165 | BUB3-interacting and GLEBS motif-containing protein ZNF207; Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered lo [...] |
| CCDC66 protein network | https://string-db.org/network/9606.ENSP00000378167 | Microtubule-binding protein required for ciliogenesis . May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centr [...] |
| SGMS2 protein network | https://string-db.org/network/9606.ENSP00000378176 | Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, [...] |
| CEMIP protein network | https://string-db.org/network/9606.ENSP00000378177 | Cell migration-inducing and hyaluronan-binding protein; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluron [...] |
| BRD7 protein network | https://string-db.org/network/9606.ENSP00000378181 | Bromodomain-containing protein 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negati [...] |
| ADCY7 protein network | https://string-db.org/network/9606.ENSP00000378187 | Adenylate cyclase type 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase; Adenylate cyclases |
| AIMP1 protein network | https://string-db.org/network/9606.ENSP00000378191 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase [...] |
| DMTF1 protein network | https://string-db.org/network/9606.ENSP00000378193 | Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arre [...] |
| GPR75 protein network | https://string-db.org/network/9606.ENSP00000378195 | Probable G-protein coupled receptor 75; G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosp [...] |
| HSPA2 protein network | https://string-db.org/network/9606.ENSP00000378199 | Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synth [...] |
| AKAP5 protein network | https://string-db.org/network/9606.ENSP00000378207 | A-kinase anchor protein 5; May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association w [...] |
| PRKCD protein network | https://string-db.org/network/9606.ENSP00000378217 | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by [...] |
| ABCC11 protein network | https://string-db.org/network/9606.ENSP00000378230 | ATP-binding cassette sub-family C member 11; Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and [...] |
| SFMBT1 protein network | https://string-db.org/network/9606.ENSP00000378235 | Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by c [...] |
| STON1-GTF2A1L protein network | https://string-db.org/network/9606.ENSP00000378236 | May be involved in the endocytic machinery. |
| CXXC4 protein network | https://string-db.org/network/9606.ENSP00000378248 | CXXC-type zinc finger protein 4; Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1; Zinc fingers CXXC-type |
| EML3 protein network | https://string-db.org/network/9606.ENSP00000378254 | Echinoderm microtubule-associated protein-like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing |
| ALG13 protein network | https://string-db.org/network/9606.ENSP00000378260 | Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13; Isoform 1: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities; Belongs [...] |
| SLC9B2 protein network | https://string-db.org/network/9606.ENSP00000378265 | Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium h [...] |
| PAIP2 protein network | https://string-db.org/network/9606.ENSP00000378275 | Polyadenylate-binding protein-interacting protein 2; Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediate [...] |
| ZBTB3 protein network | https://string-db.org/network/9606.ENSP00000378286 | Zinc finger and BTB domain-containing protein 3; May be involved in transcriptional regulation; BTB domain containing |
| MYLK3 protein network | https://string-db.org/network/9606.ENSP00000378288 | Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility (By similarity) |
| SYNPO2L protein network | https://string-db.org/network/9606.ENSP00000378289 | Synaptopodin 2-like protein; Actin-associated protein that may play a role in modulating actin-based shape; PDZ domain containing |
| KRT80 protein network | https://string-db.org/network/9606.ENSP00000378292 | Keratin, type II cytoskeletal 80; Keratins, type II |
| SIL1 protein network | https://string-db.org/network/9606.ENSP00000378294 | Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5; Be [...] |
| INCENP protein network | https://string-db.org/network/9606.ENSP00000378295 | Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ens [...] |
| PPP3CB protein network | https://string-db.org/network/9606.ENSP00000378306 | Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of [...] |
| PBRM1 protein network | https://string-db.org/network/9606.ENSP00000378307 | Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/S [...] |
| SLC39A8 protein network | https://string-db.org/network/9606.ENSP00000378310 | Zinc transporter ZIP8; Acts as a manganese and zinc influx transporter. Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain; Belongs [...] |
| EFCAB5 protein network | https://string-db.org/network/9606.ENSP00000378312 | EF-hand calcium-binding domain-containing protein 5; EF-hand calcium binding domain 5 |
| RAB3IL1 protein network | https://string-db.org/network/9606.ENSP00000378313 | Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP [...] |
| TTC7A protein network | https://string-db.org/network/9606.ENSP00000378320 | Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinosit [...] |
| PPP3CA protein network | https://string-db.org/network/9606.ENSP00000378323 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit [...] |
| DNAJA4 protein network | https://string-db.org/network/9606.ENSP00000378324 | DnaJ heat shock protein family member A4 |
| ZP3 protein network | https://string-db.org/network/9606.ENSP00000378326 | Zona pellucida sperm-binding protein 3; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy [...] |
| ANKRD13B protein network | https://string-db.org/network/9606.ENSP00000378328 | Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...] |
| TGFB1I1 protein network | https://string-db.org/network/9606.ENSP00000378332 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleu [...] |
| GIT1 protein network | https://string-db.org/network/9606.ENSP00000378338 | ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling ves [...] |
| COL4A6 protein network | https://string-db.org/network/9606.ENSP00000378340 | Collagen alpha-6(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| CDC23 protein network | https://string-db.org/network/9606.ENSP00000378350 | Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| KIF20A protein network | https://string-db.org/network/9606.ENSP00000378356 | Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the centra [...] |
| ADH6 protein network | https://string-db.org/network/9606.ENSP00000378359 | Alcohol dehydrogenase 6 |
| DAK protein network | https://string-db.org/network/9606.ENSP00000378360 | Triokinase/FMN cyclase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best subst [...] |
| SLC11A2 protein network | https://string-db.org/network/9606.ENSP00000378364 | Natural resistance-associated macrophage protein 2; Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical [...] |
| CCL26 protein network | https://string-db.org/network/9606.ENSP00000378365 | C-C motif chemokine 26; Chemoattractant for eosinophils and basophils. Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca(2+) mobilization in eosinophils; Belongs to the intercrin [...] |
| NRG4 protein network | https://string-db.org/network/9606.ENSP00000378367 | Pro-neuregulin-4, membrane-bound isoform; Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine p [...] |
| FLOT2 protein network | https://string-db.org/network/9606.ENSP00000378368 | Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion [...] |
| PSAP protein network | https://string-db.org/network/9606.ENSP00000378394 | Prosaposin; Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific h [...] |
| WDR89 protein network | https://string-db.org/network/9606.ENSP00000378399 | WD repeat-containing protein 89; WD repeat domain containing |
| LIMA1 protein network | https://string-db.org/network/9606.ENSP00000378400 | LIM domain and actin-binding protein 1; Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolym [...] |
| SPOCK1 protein network | https://string-db.org/network/9606.ENSP00000378401 | Testican-1; May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system; SPARC family |
| SIN3A protein network | https://string-db.org/network/9606.ENSP00000378402 | Paired amphipathic helix protein Sin3a; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Als [...] |
| BCKDK protein network | https://string-db.org/network/9606.ENSP00000378405 | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regul [...] |
| GPT protein network | https://string-db.org/network/9606.ENSP00000378408 | Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liv [...] |
| C10orf54 protein network | https://string-db.org/network/9606.ENSP00000378409 | V-type immunoglobulin domain-containing suppressor of T-cell activation; Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhi [...] |
| SMARCD1 protein network | https://string-db.org/network/9606.ENSP00000378414 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...] |
| ALAS1 protein network | https://string-db.org/network/9606.ENSP00000378416 | 5-aminolevulinate synthase, nonspecific, mitochondrial; 5'-aminolevulinate synthase 1; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family |
| SP9 protein network | https://string-db.org/network/9606.ENSP00000378418 | Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgro [...] |
| VKORC1 protein network | https://string-db.org/network/9606.ENSP00000378426 | Vitamin K epoxide reductase complex subunit 1; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide t [...] |
| C5orf24 protein network | https://string-db.org/network/9606.ENSP00000378427 | UPF0461 protein C5orf24; Chromosome 5 open reading frame 24; Belongs to the UPF0461 family |
| MMRN1 protein network | https://string-db.org/network/9606.ENSP00000378431 | Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may li [...] |
| CPLX3 protein network | https://string-db.org/network/9606.ENSP00000378464 | Complexin-3; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family |
| RGS19 protein network | https://string-db.org/network/9606.ENSP00000378483 | Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G [...] |
| MATK protein network | https://string-db.org/network/9606.ENSP00000378485 | Megakaryocyte-associated tyrosine-protein kinase; Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in b [...] |
| GRM2 protein network | https://string-db.org/network/9606.ENSP00000378492 | Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| ZBTB9 protein network | https://string-db.org/network/9606.ENSP00000378503 | Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation; BTB domain containing |
| NXF3 protein network | https://string-db.org/network/9606.ENSP00000378504 | Nuclear RNA export factor 3; May function as a tissue-specific nuclear mRNA export factor |
| CLK3 protein network | https://string-db.org/network/9606.ENSP00000378505 | Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spl [...] |
| OR10W1 protein network | https://string-db.org/network/9606.ENSP00000378516 | Olfactory receptor 10W1; Odorant receptor; Olfactory receptors, family 10 |
| SPP1 protein network | https://string-db.org/network/9606.ENSP00000378517 | Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Endogenous ligands |
| FZR1 protein network | https://string-db.org/network/9606.ENSP00000378529 | Fizzy-related protein homolog; Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in r [...] |
| ZBTB46 protein network | https://string-db.org/network/9606.ENSP00000378536 | Zinc finger and BTB domain-containing protein 46; Function as a transcriptional repressor for PRDM1; BTB domain containing |
| GPR135 protein network | https://string-db.org/network/9606.ENSP00000378548 | Probable G-protein coupled receptor 135; Orphan receptor; G protein-coupled receptors, Class A orphans |
| DAAM1 protein network | https://string-db.org/network/9606.ENSP00000378557 | Disheveled-associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho [...] |
| PFDN6 protein network | https://string-db.org/network/9606.ENSP00000378563 | Prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| SULT1A3 protein network | https://string-db.org/network/9606.ENSP00000378570 | Sulfotransferase 1A3; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as [...] |
| CLDN3 protein network | https://string-db.org/network/9606.ENSP00000378577 | Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family |
| AFF1 protein network | https://string-db.org/network/9606.ENSP00000378578 | AF4/FMR2 family member 1 |
| TIMM9 protein network | https://string-db.org/network/9606.ENSP00000378588 | Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mit [...] |
| DNAJC30 protein network | https://string-db.org/network/9606.ENSP00000378605 | DnaJ heat shock protein family member C30 |
| ARHGAP24 protein network | https://string-db.org/network/9606.ENSP00000378611 | Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by con [...] |
| HERC4 protein network | https://string-db.org/network/9606.ENSP00000378624 | Probable E3 ubiquitin-protein ligase HERC4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon ma [...] |
| DRP2 protein network | https://string-db.org/network/9606.ENSP00000378635 | Dystrophin-related protein 2; Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX l [...] |
| ZNF785 protein network | https://string-db.org/network/9606.ENSP00000378642 | Zinc finger protein 785; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TBX6 protein network | https://string-db.org/network/9606.ENSP00000378650 | T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulatin [...] |
| ALDOA protein network | https://string-db.org/network/9606.ENSP00000378669 | Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity); Belongs to the class I fructose-bispho [...] |
| POM121 protein network | https://string-db.org/network/9606.ENSP00000378687 | Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to [...] |
| CALN1 protein network | https://string-db.org/network/9606.ENSP00000378690 | Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of ne [...] |
| CDK1 protein network | https://string-db.org/network/9606.ENSP00000378699 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 pro [...] |
| BRD2 protein network | https://string-db.org/network/9606.ENSP00000378704 | Bromodomain-containing protein 2; May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, prob [...] |
| FAM135B protein network | https://string-db.org/network/9606.ENSP00000378710 | Protein FAM135B; Family with sequence similarity 135 member B |
| IZUMO4 protein network | https://string-db.org/network/9606.ENSP00000378712 | Izumo sperm-egg fusion protein 4; IZUMO family member 4; Belongs to the Izumo family |
| SEC31A protein network | https://string-db.org/network/9606.ENSP00000378721 | Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| KTN1 protein network | https://string-db.org/network/9606.ENSP00000378725 | Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin; Belongs to the ki [...] |
| LBH protein network | https://string-db.org/network/9606.ENSP00000378733 | Protein LBH; Transcriptional activator which may act in mitogen- activated protein kinase signaling pathway; Belongs to the LBH family |
| CRCP protein network | https://string-db.org/network/9606.ENSP00000378736 | DNA-directed RNA polymerase III subunit RPC9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| AK4 protein network | https://string-db.org/network/9606.ENSP00000378743 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and d [...] |
| SLC16A9 protein network | https://string-db.org/network/9606.ENSP00000378757 | Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane; Solute carriers |
| MVP protein network | https://string-db.org/network/9606.ENSP00000378760 | Major vault protein; Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role [...] |
| PPP1CB protein network | https://string-db.org/network/9606.ENSP00000378769 | Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hu [...] |
| QPRT protein network | https://string-db.org/network/9606.ENSP00000378782 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA); Belongs to the NadC/ModD family |
| PHF20L1 protein network | https://string-db.org/network/9606.ENSP00000378784 | PHD finger protein 20 like 1 |
| HLA-DRA protein network | https://string-db.org/network/9606.ENSP00000378786 | HLA class II histocompatibility antigen, DR alpha chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surfa [...] |
| ZNF169 protein network | https://string-db.org/network/9606.ENSP00000378792 | Zinc finger protein 169; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PAQR5 protein network | https://string-db.org/network/9606.ENSP00000378803 | Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation; Progestin [...] |
| CHCHD2 protein network | https://string-db.org/network/9606.ENSP00000378812 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4 [...] |
| QRICH1 protein network | https://string-db.org/network/9606.ENSP00000378830 | Glutamine-rich protein 1; Glutamine rich 1 |
| LAT protein network | https://string-db.org/network/9606.ENSP00000378845 | Linker for activation of T cells |
| MAPK1IP1L protein network | https://string-db.org/network/9606.ENSP00000378851 | MAPK-interacting and spindle-stabilizing protein-like; Mitogen-activated protein kinase 1 interacting protein 1 like |
| PSPH protein network | https://string-db.org/network/9606.ENSP00000378854 | Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates; HAD As [...] |
| SOCS4 protein network | https://string-db.org/network/9606.ENSP00000378855 | Suppressor of cytokine signaling 4; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-li [...] |
| LGALS9 protein network | https://string-db.org/network/9606.ENSP00000378856 | Galectin-9; Binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bacte [...] |
| WDR6 protein network | https://string-db.org/network/9606.ENSP00000378857 | WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy; WD repeat domain containing |
| A1CF protein network | https://string-db.org/network/9606.ENSP00000378868 | APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA cod [...] |
| AGPAT1 protein network | https://string-db.org/network/9606.ENSP00000378877 | 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone; 1- [...] |
| ZNF484 protein network | https://string-db.org/network/9606.ENSP00000378881 | Zinc finger protein 484; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DHRS7B protein network | https://string-db.org/network/9606.ENSP00000378887 | Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily |
| EGFL8 protein network | https://string-db.org/network/9606.ENSP00000378888 | Epidermal growth factor-like protein 8; EGF like domain multiple 8 |
| ASAH2 protein network | https://string-db.org/network/9606.ENSP00000378897 | Neutral ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generat [...] |
| COBL protein network | https://string-db.org/network/9606.ENSP00000378912 | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite bra [...] |
| ULK2 protein network | https://string-db.org/network/9606.ENSP00000378914 | Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the forma [...] |
| ATXN2L protein network | https://string-db.org/network/9606.ENSP00000378917 | Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation; Belongs to the ataxin-2 family |
| SLC26A6 protein network | https://string-db.org/network/9606.ENSP00000378920 | Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeosta [...] |
| PPHLN1 protein network | https://string-db.org/network/9606.ENSP00000378935 | Periphilin-1; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to [...] |
| MFAP4 protein network | https://string-db.org/network/9606.ENSP00000378957 | Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance; Fibrino [...] |
| RABL2B protein network | https://string-db.org/network/9606.ENSP00000378958 | Rab-like protein 2B; RAB, member of RAS oncogene family like 2B |
| SNTB1 protein network | https://string-db.org/network/9606.ENSP00000378965 | Beta-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and th [...] |
| SULT1A1 protein network | https://string-db.org/network/9606.ENSP00000378972 | Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransm [...] |
| MAPK8 protein network | https://string-db.org/network/9606.ENSP00000378974 | Mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. [...] |
| SULT1A2 protein network | https://string-db.org/network/9606.ENSP00000378992 | Sulfotransferase 1A2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransm [...] |
| NREP protein network | https://string-db.org/network/9606.ENSP00000378996 | Neuronal regeneration-related protein; May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration (By similarity). May also have functio [...] |
| NUPR1 protein network | https://string-db.org/network/9606.ENSP00000379003 | Nuclear protein 1, transcriptional regulator |
| SLC5A10 protein network | https://string-db.org/network/9606.ENSP00000379008 | Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) f [...] |
| CPT1B protein network | https://string-db.org/network/9606.ENSP00000379011 | Carnitine O-palmitoyltransferase 1, muscle isoform; Carnitine palmitoyltransferase 1B |
| FBXW10 protein network | https://string-db.org/network/9606.ENSP00000379025 | F-box/WD repeat-containing protein 10; Probable substrate-recognition component of a SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subseque [...] |
| EXT2 protein network | https://string-db.org/network/9606.ENSP00000379032 | Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan-sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appea [...] |
| KLHDC7B protein network | https://string-db.org/network/9606.ENSP00000379034 | Kelch domain containing 7B |
| TYMP protein network | https://string-db.org/network/9606.ENSP00000379038 | Thymidine phosphorylase; May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activit [...] |
| ERO1L protein network | https://string-db.org/network/9606.ENSP00000379042 | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in o [...] |
| CCDC51 protein network | https://string-db.org/network/9606.ENSP00000379047 | Mitochondrial potassium channel located in the mitochondrial inner membrane . Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potas [...] |
| PURB protein network | https://string-db.org/network/9606.ENSP00000379051 | Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gen [...] |
| MIEF2 protein network | https://string-db.org/network/9606.ENSP00000379057 | Mitochondrial dynamics protein MID49; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related [...] |
| TRPS1 protein network | https://string-db.org/network/9606.ENSP00000379065 | Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate [...] |
| ADM2 protein network | https://string-db.org/network/9606.ENSP00000379087 | ADM2; IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pat [...] |
| BTC protein network | https://string-db.org/network/9606.ENSP00000379092 | Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells |
| AREG protein network | https://string-db.org/network/9606.ENSP00000379097 | Amphiregulin; Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts; Belongs to the a [...] |
| CAMK2B protein network | https://string-db.org/network/9606.ENSP00000379098 | Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, [...] |
| MTHFD2L protein network | https://string-db.org/network/9606.ENSP00000379108 | Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2; Methylenetetrahydrofolate dehydrogenase 2 like |
| CXCL1 protein network | https://string-db.org/network/9606.ENSP00000379110 | Growth-regulated alpha protein; Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the proces [...] |
| IL4R protein network | https://string-db.org/network/9606.ENSP00000379111 | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The [...] |
| APIP protein network | https://string-db.org/network/9606.ENSP00000379133 | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Functions in the [...] |
| AFP protein network | https://string-db.org/network/9606.ENSP00000379138 | Alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding pr [...] |
| CXCL12 protein network | https://string-db.org/network/9606.ENSP00000379140 | Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the le [...] |
| ZNF32 protein network | https://string-db.org/network/9606.ENSP00000379143 | Zinc finger protein 32; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TNRC6A protein network | https://string-db.org/network/9606.ENSP00000379144 | Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repressi [...] |
| MPRIP protein network | https://string-db.org/network/9606.ENSP00000379156 | Myosin phosphatase Rho-interacting protein; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an in [...] |
| CAST protein network | https://string-db.org/network/9606.ENSP00000379157 | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein deg [...] |
| ZNF287 protein network | https://string-db.org/network/9606.ENSP00000379168 | Zinc finger protein 287; May be involved in transcriptional regulation; SCAN domain containing |
| POLM protein network | https://string-db.org/network/9606.ENSP00000379174 | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain ge [...] |
| CDKL1 protein network | https://string-db.org/network/9606.ENSP00000379176 | Cyclin-dependent kinase-like 1; Cyclin dependent kinase like 1 |
| RAE1 protein network | https://string-db.org/network/9606.ENSP00000379182 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cyt [...] |
| PANX2 protein network | https://string-db.org/network/9606.ENSP00000379183 | Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family |
| CD59 protein network | https://string-db.org/network/9606.ENSP00000379191 | CD59 glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation [...] |
| VCPKMT protein network | https://string-db.org/network/9606.ENSP00000379201 | Protein-lysine methyltransferase METTL21D; Protein-lysine N-methyltransferase that specifically trimethylates 'Lys-315' of VCP/p97; this modification may decrease VCP ATPase activity; Belongs to [...] |
| ATP6V1C1 protein network | https://string-db.org/network/9606.ENSP00000379203 | V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a sp [...] |
| BMP7 protein network | https://string-db.org/network/9606.ENSP00000379204 | Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation [...] |
| ZNF248 protein network | https://string-db.org/network/9606.ENSP00000379208 | Zinc finger protein 248; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MYL3 protein network | https://string-db.org/network/9606.ENSP00000379210 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing |
| UBFD1 protein network | https://string-db.org/network/9606.ENSP00000379217 | Ubiquitin domain-containing protein UBFD1; May play a role as NF-kappa-B regulator |
| COA1 protein network | https://string-db.org/network/9606.ENSP00000379218 | Cytochrome c oxidase assembly factor 1 homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytoch [...] |
| TEX11 protein network | https://string-db.org/network/9606.ENSP00000379226 | Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers (By similarity) |
| HECW1 protein network | https://string-db.org/network/9606.ENSP00000379228 | E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotroph [...] |
| LRRC2 protein network | https://string-db.org/network/9606.ENSP00000379241 | Leucine-rich repeat-containing protein 2; Leucine rich repeat containing 2 |
| CDRT1 protein network | https://string-db.org/network/9606.ENSP00000379242 | CMT1A duplicated region transcript 1 protein; F-box and WD repeat domain containing |
| NCALD protein network | https://string-db.org/network/9606.ENSP00000379256 | Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions; EF-hand domain containing |
| GLI3 protein network | https://string-db.org/network/9606.ENSP00000379258 | Transcriptional activator GLI3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 [...] |
| TEKT3 protein network | https://string-db.org/network/9606.ENSP00000379263 | Tektin-3; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for progressive sperm mobility (By si [...] |
| ELP4 protein network | https://string-db.org/network/9606.ENSP00000379267 | Elongator complex protein 4; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involve [...] |
| ABHD16A protein network | https://string-db.org/network/9606.ENSP00000379282 | Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS) (By similarity). LPS constitutes a class of signaling lipids that regula [...] |
| YWHAZ protein network | https://string-db.org/network/9606.ENSP00000379287 | 14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by rec [...] |
| BCAS1 protein network | https://string-db.org/network/9606.ENSP00000379290 | Breast carcinoma amplified sequence 1 |
| FAM172A protein network | https://string-db.org/network/9606.ENSP00000379294 | Protein FAM172A; Family with sequence similarity 172 member A; Belongs to the UPF0528 family |
| CASC1 protein network | https://string-db.org/network/9606.ENSP00000379310 | Protein phosphatase 1 regulatory subunits |
| SLC5A12 protein network | https://string-db.org/network/9606.ENSP00000379326 | Sodium-coupled monocarboxylate transporter 2; Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma memb [...] |
| PRR34 protein network | https://string-db.org/network/9606.ENSP00000379329 | Proline-rich protein 34; Proline rich 34 |
| NFATC2 protein network | https://string-db.org/network/9606.ENSP00000379330 | Nuclear factor of activated T-cells, cytoplasmic 2; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF [...] |
| RPS29 protein network | https://string-db.org/network/9606.ENSP00000379339 | Ribosomal protein S29 |
| ADNP protein network | https://string-db.org/network/9606.ENSP00000379346 | Activity-dependent neuroprotector homeobox protein; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proli [...] |
| ITGB1 protein network | https://string-db.org/network/9606.ENSP00000379350 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydr [...] |
| ST8SIA1 protein network | https://string-db.org/network/9606.ENSP00000379353 | Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one [...] |
| MOB1A protein network | https://string-db.org/network/9606.ENSP00000379364 | MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apop [...] |
| EDA2R protein network | https://string-db.org/network/9606.ENSP00000379365 | Tumor necrosis factor receptor superfamily member 27; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be m [...] |
| MOB1B protein network | https://string-db.org/network/9606.ENSP00000379366 | MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apop [...] |
| LYRM1 protein network | https://string-db.org/network/9606.ENSP00000379367 | LYR motif-containing protein 1; May promote cell proliferation and inhibition of apoptosis of preadipocytes; Belongs to the complex I LYR family |
| ZNF35 protein network | https://string-db.org/network/9606.ENSP00000379368 | Zinc finger protein 35; May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation; Zinc fingers C2H2-type |
| FOXB1 protein network | https://string-db.org/network/9606.ENSP00000379369 | Forkhead box B1 |
| ZNF197 protein network | https://string-db.org/network/9606.ENSP00000379370 | Zinc finger protein 197; May be involved in transcriptional regulation; SCAN domain containing |
| GTF2A2 protein network | https://string-db.org/network/9606.ENSP00000379372 | Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a compl [...] |
| GCNT3 protein network | https://string-db.org/network/9606.ENSP00000379377 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and [...] |
| ENAM protein network | https://string-db.org/network/9606.ENSP00000379383 | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation |
| LDHB protein network | https://string-db.org/network/9606.ENSP00000379386 | Lactate dehydrogenase B; Belongs to the LDH/MDH superfamily. LDH family |
| HERPUD2 protein network | https://string-db.org/network/9606.ENSP00000379390 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway |
| NAV2 protein network | https://string-db.org/network/9606.ENSP00000379396 | Neuron navigator 2; Possesses 3' to 5' helicase activity and exonuclease activity. Involved in neuronal development, specifically in the development of different sensory organs; Belongs to the Na [...] |
| ODAM protein network | https://string-db.org/network/9606.ENSP00000379401 | Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the [...] |
| ZNFX1 protein network | https://string-db.org/network/9606.ENSP00000379412 | Zinc finger NFX1-type containing 1; UPF1 like RNA helicases |
| NDUFAF6 protein network | https://string-db.org/network/9606.ENSP00000379430 | NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the [...] |
| KLHL28 protein network | https://string-db.org/network/9606.ENSP00000379434 | Kelch-like protein 28; Kelch like family member 28; BTB domain containing |
| UMOD protein network | https://string-db.org/network/9606.ENSP00000379438 | Uromodulin; Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of comp [...] |
| JMY protein network | https://string-db.org/network/9606.ENSP00000379441 | Junction-mediating and -regulatory protein; Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that inc [...] |
| ZNF418 protein network | https://string-db.org/network/9606.ENSP00000379451 | Zinc finger protein 418; Transcriptional repressor; Zinc fingers C2H2-type |
| FAF1 protein network | https://string-db.org/network/9606.ENSP00000379457 | FAS-associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis; UBX domain containing |
| ZNF586 protein network | https://string-db.org/network/9606.ENSP00000379458 | Zinc finger protein 586; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CTAGE5 protein network | https://string-db.org/network/9606.ENSP00000379462 | Endoplasmic reticulum export factor CTAGE5; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into me [...] |
| ZNF134 protein network | https://string-db.org/network/9606.ENSP00000379464 | Zinc finger protein 134; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CCK protein network | https://string-db.org/network/9606.ENSP00000379472 | Cholecystokinin; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimula [...] |
| DDX39B protein network | https://string-db.org/network/9606.ENSP00000379475 | Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and n [...] |
| PDE1C protein network | https://string-db.org/network/9606.ENSP00000379496 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regu [...] |
| UEVLD protein network | https://string-db.org/network/9606.ENSP00000379500 | Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination; In the N-terminal section; belongs to the ubiquitin- conjugating enzyme family. UEV subfamily |
| PDP1 protein network | https://string-db.org/network/9606.ENSP00000379503 | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate [...] |
| RPL14 protein network | https://string-db.org/network/9606.ENSP00000379506 | 60S ribosomal protein L14; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL14 family |
| MGST1 protein network | https://string-db.org/network/9606.ENSP00000379512 | Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity; Microsomal glu [...] |
| TMC5 protein network | https://string-db.org/network/9606.ENSP00000379531 | Transmembrane channel-like protein 5; Probable ion channel; Transmembrane channel likes |
| TSPO protein network | https://string-db.org/network/9606.ENSP00000379563 | Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes [...] |
| CCHCR1 protein network | https://string-db.org/network/9606.ENSP00000379566 | Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation |
| ACBD5 protein network | https://string-db.org/network/9606.ENSP00000379568 | Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medi [...] |
| MRGPRX3 protein network | https://string-db.org/network/9606.ENSP00000379571 | Mas-related G-protein coupled receptor member X3; Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sen [...] |
| RAB27A protein network | https://string-db.org/network/9606.ENSP00000379601 | Ras-related protein Rab-27A; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse; RAB, mem [...] |
| VAMP1 protein network | https://string-db.org/network/9606.ENSP00000379602 | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane |
| KNCN protein network | https://string-db.org/network/9606.ENSP00000379607 | Kinocilin |
| TAX1BP1 protein network | https://string-db.org/network/9606.ENSP00000379612 | Tax1-binding protein 1; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a rol [...] |
| MYH11 protein network | https://string-db.org/network/9606.ENSP00000379616 | Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family |
| WDR72 protein network | https://string-db.org/network/9606.ENSP00000379619 | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and c [...] |
| SNX16 protein network | https://string-db.org/network/9606.ENSP00000379621 | Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome [...] |
| NDE1 protein network | https://string-db.org/network/9606.ENSP00000379643 | Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regul [...] |
| SOX6 protein network | https://string-db.org/network/9606.ENSP00000379644 | Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleto [...] |
| LILRA6 protein network | https://string-db.org/network/9606.ENSP00000379651 | Leukocyte immunoglobulin-like receptor subfamily A member 6; May act as receptor for class I MHC antigens; Activating leukocyte immunoglobulin like receptors |
| KIAA0430 protein network | https://string-db.org/network/9606.ENSP00000379654 | Meiosis regulator and mRNA stability factor 1; Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which i [...] |
| ETV6 protein network | https://string-db.org/network/9606.ENSP00000379658 | Transcription factor ETV6; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation; Belongs to the ETS family |
| MPV17L protein network | https://string-db.org/network/9606.ENSP00000379669 | Mpv17-like protein; Isoform 1 participates in reactive oxygen species metablism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 [...] |
| PGM5 protein network | https://string-db.org/network/9606.ENSP00000379678 | Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity |
| NAGA protein network | https://string-db.org/network/9606.ENSP00000379680 | Alpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids |
| PRH2 protein network | https://string-db.org/network/9606.ENSP00000379682 | Salivary acidic proline-rich phosphoprotein 1/2; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental ena [...] |
| CYP19A1 protein network | https://string-db.org/network/9606.ENSP00000379683 | Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens; Cytochrome P450 family 19 |
| ZNF813 protein network | https://string-db.org/network/9606.ENSP00000379684 | Zinc finger protein 813; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF765 protein network | https://string-db.org/network/9606.ENSP00000379689 | Zinc finger protein 765; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PDXDC1 protein network | https://string-db.org/network/9606.ENSP00000379691 | Pyridoxal-dependent decarboxylase domain-containing protein 1; Pyridoxal dependent decarboxylase domain containing 1; Belongs to the group II decarboxylase family |
| PKIA protein network | https://string-db.org/network/9606.ENSP00000379696 | cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme af [...] |
| HNF4G protein network | https://string-db.org/network/9606.ENSP00000379701 | Hepatocyte nuclear factor 4-gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha; Belongs to the nuclear hormone receptor family. NR2 subfamily |
| ZNF665 protein network | https://string-db.org/network/9606.ENSP00000379702 | Zinc finger protein 665; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SEPT3 protein network | https://string-db.org/network/9606.ENSP00000379704 | Neuronal-specific septin-3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase su [...] |
| ARHGAP21 protein network | https://string-db.org/network/9606.ENSP00000379709 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also requ [...] |
| IQSEC2 protein network | https://string-db.org/network/9606.ENSP00000379712 | IQ motif and SEC7 domain-containing protein 2; Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins; X-linked mental retardation |
| USP8 protein network | https://string-db.org/network/9606.ENSP00000379721 | Ubiquitin carboxyl-terminal hydrolase 8; Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventi [...] |
| CEACAM18 protein network | https://string-db.org/network/9606.ENSP00000379738 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| IPP protein network | https://string-db.org/network/9606.ENSP00000379739 | Actin-binding protein IPP; May play a role in organizing the actin cytoskeleton; BTB domain containing |
| CCDC125 protein network | https://string-db.org/network/9606.ENSP00000379754 | Coiled-coil domain-containing protein 125; May be involved in the regulation of cell migration |
| DKK3 protein network | https://string-db.org/network/9606.ENSP00000379762 | Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes inte [...] |
| ZC3H7A protein network | https://string-db.org/network/9606.ENSP00000379773 | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the [...] |
| COX7B2 protein network | https://string-db.org/network/9606.ENSP00000379784 | Cytochrome c oxidase subunit 7B2, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| AMPD3 protein network | https://string-db.org/network/9606.ENSP00000379802 | AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family |
| OSBPL10 protein network | https://string-db.org/network/9606.ENSP00000379804 | Oxysterol-binding protein-related protein 10; Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphat [...] |
| ATF7IP2 protein network | https://string-db.org/network/9606.ENSP00000379808 | Activating transcription factor 7-interacting protein 2; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chrom [...] |
| GRIN2A protein network | https://string-db.org/network/9606.ENSP00000379818 | Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...] |
| SLC12A1 protein network | https://string-db.org/network/9606.ENSP00000379822 | Solute carrier family 12 member 1; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume; Belong [...] |
| COL4A3 protein network | https://string-db.org/network/9606.ENSP00000379823 | Collagen alpha-3(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| TRIM40 protein network | https://string-db.org/network/9606.ENSP00000379826 | Tripartite motif-containing protein 40; May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of [...] |
| SLC30A5 protein network | https://string-db.org/network/9606.ENSP00000379836 | Zinc transporter 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 [...] |
| CARHSP1 protein network | https://string-db.org/network/9606.ENSP00000379838 | Calcium-regulated heat-stable protein 1; Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro) |
| GNE protein network | https://string-db.org/network/9606.ENSP00000379839 | Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N- acetylneuraminic acid (NeuAc), a precursor of sialic acids. Plays an essent [...] |
| SGK3 protein network | https://string-db.org/network/9606.ENSP00000379842 | Serum/glucocorticoid regulated kinase family, member 3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, [...] |
| ABAT protein network | https://string-db.org/network/9606.ENSP00000379845 | 4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respective [...] |
| ZNF143 protein network | https://string-db.org/network/9606.ENSP00000379847 | Zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in effic [...] |
| COCH protein network | https://string-db.org/network/9606.ENSP00000379862 | Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork; Deafness associated genes |
| ADHFE1 protein network | https://string-db.org/network/9606.ENSP00000379865 | Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of [...] |
| COL4A4 protein network | https://string-db.org/network/9606.ENSP00000379866 | Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and [...] |
| ELP5 protein network | https://string-db.org/network/9606.ENSP00000379869 | Elongator complex protein 5; Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involve [...] |
| HLA-A protein network | https://string-db.org/network/9606.ENSP00000379873 | HLA class I histocompatibility antigen, A-3 alpha chain; Involved in the presentation of foreign antigens to the immune system; C1-set domain containing |
| LRRC3B protein network | https://string-db.org/network/9606.ENSP00000379880 | Leucine-rich repeat-containing protein 3B; Leucine rich repeat containing 3B |
| RPS8 protein network | https://string-db.org/network/9606.ENSP00000379888 | Ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family |
| AP1S3 protein network | https://string-db.org/network/9606.ENSP00000379891 | AP-1 complex subunit sigma-3; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...] |
| UBN1 protein network | https://string-db.org/network/9606.ENSP00000379894 | Ubinuclein-1; Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. [...] |
| GATM protein network | https://string-db.org/network/9606.ENSP00000379895 | Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. [...] |
| ARL4A protein network | https://string-db.org/network/9606.ENSP00000379898 | ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleot [...] |
| TMEM106B protein network | https://string-db.org/network/9606.ENSP00000379901 | Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lys [...] |
| THRB protein network | https://string-db.org/network/9606.ENSP00000379904 | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyr [...] |
| CENPK protein network | https://string-db.org/network/9606.ENSP00000379911 | Centromere protein K; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chr [...] |
| UBE2E2 protein network | https://string-db.org/network/9606.ENSP00000379931 | Ubiquitin-conjugating enzyme E2 E2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63' [...] |
| ZDHHC4 protein network | https://string-db.org/network/9606.ENSP00000379934 | Probable palmitoyltransferase ZDHHC4; Zinc finger DHHC-type containing 4; Belongs to the DHHC palmitoyltransferase family |
| GLTSCR1 protein network | https://string-db.org/network/9606.ENSP00000379946 | BRD4-interacting chromatin-remodeling complex-associated protein; May play a role in BRD4-mediated gene transcription |
| ILK protein network | https://string-db.org/network/9606.ENSP00000379975 | Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein [...] |
| CD72 protein network | https://string-db.org/network/9606.ENSP00000379980 | B-cell differentiation antigen CD72; Plays a role in B-cell proliferation and differentiation; C-type lectin domain containing |
| GAPT protein network | https://string-db.org/network/9606.ENSP00000379997 | Protein GAPT; Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity); [...] |
| TIMM17B protein network | https://string-db.org/network/9606.ENSP00000379999 | Translocase of inner mitochondrial membrane 17B; TIM23 complex |
| LTB4R protein network | https://string-db.org/network/9606.ENSP00000380008 | Leukotriene B4 receptor 1; Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger sys [...] |
| ZNF384 protein network | https://string-db.org/network/9606.ENSP00000380019 | Zinc finger protein 384; Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity); Belongs to [...] |
| OR12D3 protein network | https://string-db.org/network/9606.ENSP00000380023 | Olfactory receptor 12D3; Odorant receptor; Olfactory receptors, family 12 |
| ING4 protein network | https://string-db.org/network/9606.ENSP00000380024 | Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of h [...] |
| DDX17 protein network | https://string-db.org/network/9606.ENSP00000380033 | Probable ATP-dependent RNA helicase DDX17; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRN [...] |
| SNAI2 protein network | https://string-db.org/network/9606.ENSP00000380034 | Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role [...] |
| FITM2 protein network | https://string-db.org/network/9606.ENSP00000380037 | Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization |
| CSNK1E protein network | https://string-db.org/network/9606.ENSP00000380044 | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of p [...] |
| LEUTX protein network | https://string-db.org/network/9606.ENSP00000380053 | PRD class homeoboxes and pseudogenes |
| EAF1 protein network | https://string-db.org/network/9606.ENSP00000380054 | ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities; Belongs to the EAF family |
| ZSCAN32 protein network | https://string-db.org/network/9606.ENSP00000380057 | Zinc finger and SCAN domain-containing protein 32; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TIGD7 protein network | https://string-db.org/network/9606.ENSP00000380071 | Tigger transposable element-derived protein 7; Helix-turn-helix CENPB type domain containing; Belongs to the tigger transposable element derived protein family |
| IRF9 protein network | https://string-db.org/network/9606.ENSP00000380073 | Interferon regulatory factor 9; Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and [...] |
| SLC38A9 protein network | https://string-db.org/network/9606.ENSP00000380074 | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acids. Probably acts as an amino acid sensor of the Rag [...] |
| SLC29A4 protein network | https://string-db.org/network/9606.ENSP00000380081 | Equilibrative nucleoside transporter 4; Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenyl [...] |
| ZNF213 protein network | https://string-db.org/network/9606.ENSP00000380087 | Zinc finger protein 213; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SOX10 protein network | https://string-db.org/network/9606.ENSP00000380093 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturatio [...] |
| NFKBID protein network | https://string-db.org/network/9606.ENSP00000380109 | NF-kappa-B inhibitor delta; May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May al [...] |
| RBAK-RBAKDN protein network | https://string-db.org/network/9606.ENSP00000380112 | RBAK-RBAKDN readthrough |
| PROSER3 protein network | https://string-db.org/network/9606.ENSP00000380116 | Proline and serine rich 3 |
| RBAK protein network | https://string-db.org/network/9606.ENSP00000380120 | RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CLDN6 protein network | https://string-db.org/network/9606.ENSP00000380131 | Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins |
| KAT6A protein network | https://string-db.org/network/9606.ENSP00000380136 | Histone acetyltransferase KAT6A; Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyl [...] |
| CARD11 protein network | https://string-db.org/network/9606.ENSP00000380150 | Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T- cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell prolifer [...] |
| OR51E2 protein network | https://string-db.org/network/9606.ENSP00000380153 | Olfactory receptor 51E2; Probable G protein-coupled receptor that is activated by the short chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin sec [...] |
| OR51E1 protein network | https://string-db.org/network/9606.ENSP00000380155 | Olfactory receptor 51E1; Odorant receptor; Olfactory receptors, family 51 |
| MOCS2 protein network | https://string-db.org/network/9606.ENSP00000380157 | Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the [...] |
| FLYWCH2 protein network | https://string-db.org/network/9606.ENSP00000380159 | FLYWCH family member 2 |
| ZNF182 protein network | https://string-db.org/network/9606.ENSP00000380165 | Zinc finger protein 182; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZSCAN29 protein network | https://string-db.org/network/9606.ENSP00000380174 | Zinc finger and SCAN domain-containing protein 29; May be involved in transcriptional regulation; SCAN domain containing |
| UBE2G1 protein network | https://string-db.org/network/9606.ENSP00000380178 | Ubiquitin-conjugating enzyme E2 G1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyub [...] |
| AGPAT6 protein network | https://string-db.org/network/9606.ENSP00000380184 | Glycerol-3-phosphate acyltransferase 4; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both satur [...] |
| PLEKHG6 protein network | https://string-db.org/network/9606.ENSP00000380185 | Pleckstrin homology domain-containing family G member 6; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHO [...] |
| ITGA4 protein network | https://string-db.org/network/9606.ENSP00000380227 | Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of f [...] |
| NUDT1 protein network | https://string-db.org/network/9606.ENSP00000380241 | 7,8-dihydro-8-oxoguanine triphosphatase; Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydroly [...] |
| HRH1 protein network | https://string-db.org/network/9606.ENSP00000380247 | Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal [...] |
| SLC17A3 protein network | https://string-db.org/network/9606.ENSP00000380250 | Sodium-dependent phosphate transport protein 4; Isoform 2: voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta [...] |
| NUDT19 protein network | https://string-db.org/network/9606.ENSP00000380251 | Nucleoside diphosphate-linked moiety X motif 19; Coenzyme A diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched- chain fatty-acyl-CoA este [...] |
| NFE2L2 protein network | https://string-db.org/network/9606.ENSP00000380252 | Nuclear factor erythroid 2-related factor 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-re [...] |
| CCNF protein network | https://string-db.org/network/9606.ENSP00000380256 | Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 [...] |
| ART5 protein network | https://string-db.org/network/9606.ENSP00000380258 | ADP-ribosyltransferase 5 |
| RAPGEF4 protein network | https://string-db.org/network/9606.ENSP00000380271 | Rap guanine nucleotide exchange factor 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involve [...] |
| GPER1 protein network | https://string-db.org/network/9606.ENSP00000380281 | G-protein coupled estrogen receptor 1; G-protein coupled estrogen receptor that binds to 17- beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracel [...] |
| GPR146 protein network | https://string-db.org/network/9606.ENSP00000380283 | Probable G-protein coupled receptor 146; Orphan receptor; G protein-coupled receptors, Class A orphans |
| C7orf50 protein network | https://string-db.org/network/9606.ENSP00000380286 | Uncharacterized protein C7orf50; Chromosome 7 open reading frame 50 |
| JPH4 protein network | https://string-db.org/network/9606.ENSP00000380307 | Junctophilin-4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. [...] |
| DYNC1I2 protein network | https://string-db.org/network/9606.ENSP00000380308 | Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargo [...] |
| ZNF676 protein network | https://string-db.org/network/9606.ENSP00000380310 | Zinc finger protein 676; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF208 protein network | https://string-db.org/network/9606.ENSP00000380315 | Zinc finger protein 208; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TULP3 protein network | https://string-db.org/network/9606.ENSP00000380321 | Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of [...] |
| EMC6 protein network | https://string-db.org/network/9606.ENSP00000380322 | ER membrane protein complex subunit 6; Belongs to the EMC6 family |
| ITIH5 protein network | https://string-db.org/network/9606.ENSP00000380333 | Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor |
| NCF4 protein network | https://string-db.org/network/9606.ENSP00000380334 | Neutrophil cytosol factor 4; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, [...] |
| SMU1 protein network | https://string-db.org/network/9606.ENSP00000380336 | WD40 repeat-containing protein SMU1; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Regulates alternativ [...] |
| CAPN3 protein network | https://string-db.org/network/9606.ENSP00000380349 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Calpains |
| ZNF682 protein network | https://string-db.org/network/9606.ENSP00000380351 | Zinc finger protein 682; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DDHD2 protein network | https://string-db.org/network/9606.ENSP00000380352 | Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidyli [...] |
| SFMBT2 protein network | https://string-db.org/network/9606.ENSP00000380353 | Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene; MBT domain containing |
| RGN protein network | https://string-db.org/network/9606.ENSP00000380365 | Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in [...] |
| PAFAH1B1 protein network | https://string-db.org/network/9606.ENSP00000380378 | Platelet-activating factor acetylhydrolase IB subunit alpha; Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmi [...] |
| WNT5B protein network | https://string-db.org/network/9606.ENSP00000380379 | Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete r [...] |
| FOXRED2 protein network | https://string-db.org/network/9606.ENSP00000380401 | FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endo [...] |
| MPST protein network | https://string-db.org/network/9606.ENSP00000380402 | 3-mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynt [...] |
| AGAP3 protein network | https://string-db.org/network/9606.ENSP00000380413 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation o [...] |
| DEK protein network | https://string-db.org/network/9606.ENSP00000380414 | Protein DEK; Involved in chromatin organization |
| IL15RA protein network | https://string-db.org/network/9606.ENSP00000380421 | Interleukin 15 receptor subunit alpha; CD molecules |
| ARPC4-TTLL3 protein network | https://string-db.org/network/9606.ENSP00000380427 | ARPC4-TTLL3 readthrough |
| INS protein network | https://string-db.org/network/9606.ENSP00000380432 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and [...] |
| SLC22A17 protein network | https://string-db.org/network/9606.ENSP00000380437 | Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internaliz [...] |
| INS-IGF2 protein network | https://string-db.org/network/9606.ENSP00000380440 | Insulin, isoform 2; INS-IGF2 readthrough |
| PLA2G4F protein network | https://string-db.org/network/9606.ENSP00000380442 | Cytosolic phospholipase A2 zeta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine [...] |
| NOXO1 protein network | https://string-db.org/network/9606.ENSP00000380450 | NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures [...] |
| ERMN protein network | https://string-db.org/network/9606.ENSP00000380453 | Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May p [...] |
| PLAA protein network | https://string-db.org/network/9606.ENSP00000380460 | Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins traffickin [...] |
| RPL23L protein network | https://string-db.org/network/9606.ENSP00000380466 | Mitochondrial ribosomal protein L23 |
| JMJD7 protein network | https://string-db.org/network/9606.ENSP00000380467 | JmjC domain-containing protein 7; Jumonji domain containing 7 |
| ELAVL2 protein network | https://string-db.org/network/9606.ENSP00000380479 | ELAV-like protein 2; Binds RNA. Seems to recognize a GAAA motif. Can bind to its own 3'-UTR, the FOS 3'-UTR and the ID 3'-UTR; Belongs to the RRM elav family |
| GALNT9 protein network | https://string-db.org/network/9606.ENSP00000380488 | Polypeptide N-acetylgalactosaminyltransferase 9; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| MB protein network | https://string-db.org/network/9606.ENSP00000380489 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles |
| MYCL protein network | https://string-db.org/network/9606.ENSP00000380494 | Protein L-Myc; MYCL proto-oncogene, bHLH transcription factor; Basic helix-loop-helix proteins |
| DDX51 protein network | https://string-db.org/network/9606.ENSP00000380495 | ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily |
| HAGH protein network | https://string-db.org/network/9606.ENSP00000380514 | Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactama [...] |
| HMBOX1 protein network | https://string-db.org/network/9606.ENSP00000380516 | Homeobox-containing protein 1; Transcription factor. Isoform 1 acts as a transcriptional repressor. Isoform 4 has very low activity as a transcriptional repressor; HNF class homeoboxes |
| CDH24 protein network | https://string-db.org/network/9606.ENSP00000380517 | Cadherin-24; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| CAPSL protein network | https://string-db.org/network/9606.ENSP00000380524 | Calcyphosin-like protein; EF-hand domain containing |
| DUSP8 protein network | https://string-db.org/network/9606.ENSP00000380530 | Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing [...] |
| OGFOD2 protein network | https://string-db.org/network/9606.ENSP00000380544 | 2-oxoglutarate and iron dependent oxygenase domain containing 2 |
| TSPAN4 protein network | https://string-db.org/network/9606.ENSP00000380553 | Tetraspanin-4; Tetraspanin 4; Belongs to the tetraspanin (TM4SF) family |
| AKAP8L protein network | https://string-db.org/network/9606.ENSP00000380557 | A-kinase anchor protein 8-like; Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. [...] |
| CRAMP1L protein network | https://string-db.org/network/9606.ENSP00000380559 | Crm, cramped-like (Drosophila) |
| CD151 protein network | https://string-db.org/network/9606.ENSP00000380565 | CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Blood group antigens |
| BPIFC protein network | https://string-db.org/network/9606.ENSP00000380594 | BPI fold containing family C |
| BLOC1S5 protein network | https://string-db.org/network/9606.ENSP00000380598 | Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| CNTN4 protein network | https://string-db.org/network/9606.ENSP00000380602 | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Fibronectin type III [...] |
| LYPD1 protein network | https://string-db.org/network/9606.ENSP00000380605 | Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity fo [...] |
| ARL16 protein network | https://string-db.org/network/9606.ENSP00000380635 | ADP-ribosylation factor-like protein 16; ADP ribosylation factor like GTPase 16; ARF GTPase family |
| PTK2B protein network | https://string-db.org/network/9606.ENSP00000380638 | Protein-tyrosine kinase 2-beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remod [...] |
| TMEM80 protein network | https://string-db.org/network/9606.ENSP00000380646 | Transmembrane protein 80 |
| EIF4ENIF1 protein network | https://string-db.org/network/9606.ENSP00000380659 | Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism |
| CEP250 protein network | https://string-db.org/network/9606.ENSP00000380661 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase |
| SLC7A7 protein network | https://string-db.org/network/9606.ENSP00000380666 | Y+L amino acid transporter 1; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to [...] |
| SMCO1 protein network | https://string-db.org/network/9606.ENSP00000380671 | Single-pass membrane protein with coiled-coil domains 1 |
| WEE2 protein network | https://string-db.org/network/9606.ENSP00000380675 | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required [...] |
| CCDC40 protein network | https://string-db.org/network/9606.ENSP00000380679 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby [...] |
| CCDC64 protein network | https://string-db.org/network/9606.ENSP00000380690 | BICD family-like cargo adapter 1; Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by contro [...] |
| KDM7A protein network | https://string-db.org/network/9606.ENSP00000380692 | Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 [...] |
| IRF7 protein network | https://string-db.org/network/9606.ENSP00000380697 | Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA vir [...] |
| MYCBP protein network | https://string-db.org/network/9606.ENSP00000380702 | c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC |
| RASSF7 protein network | https://string-db.org/network/9606.ENSP00000380713 | Ras association domain-containing protein 7; Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Follo [...] |
| CDYL protein network | https://string-db.org/network/9606.ENSP00000380718 | Chromodomain Y-like protein; Isoform 2: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys- 27' and trimethylated at 'Lys-27' (H3K9me3, H [...] |
| FAM98B protein network | https://string-db.org/network/9606.ENSP00000380734 | Protein FAM98B; Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation. Promotes colorectal cancer cell malignancy; tRNA splicing ligase complex |
| FBXL16 protein network | https://string-db.org/network/9606.ENSP00000380746 | F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| TMEM209 protein network | https://string-db.org/network/9606.ENSP00000380747 | Transmembrane protein 209 |
| PRMT2 protein network | https://string-db.org/network/9606.ENSP00000380759 | Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (w [...] |
| TEN1 protein network | https://string-db.org/network/9606.ENSP00000380762 | CST complex subunit TEN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication [...] |
| TCTN1 protein network | https://string-db.org/network/9606.ENSP00000380779 | Tectonic-1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between t [...] |
| NFIX protein network | https://string-db.org/network/9606.ENSP00000380781 | Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...] |
| HOOK2 protein network | https://string-db.org/network/9606.ENSP00000380785 | Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting [...] |
| ALG3 protein network | https://string-db.org/network/9606.ENSP00000380793 | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Dolichyl D-mannosyl phosphate dependent man [...] |
| CHMP7 protein network | https://string-db.org/network/9606.ENSP00000380794 | Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex pr [...] |
| MCM3AP protein network | https://string-db.org/network/9606.ENSP00000380820 | Germinal-center associated nuclear protein; Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-re [...] |
| SEPT10 protein network | https://string-db.org/network/9606.ENSP00000380824 | Septin-10; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin- like GTPase superfamily. Septin GTPase family |
| LSS protein network | https://string-db.org/network/9606.ENSP00000380837 | Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein agg [...] |
| ZNF709 protein network | https://string-db.org/network/9606.ENSP00000380840 | Zinc finger protein 709; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PDCD1LG2 protein network | https://string-db.org/network/9606.ENSP00000380855 | Programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-ce [...] |
| ZBTB44 protein network | https://string-db.org/network/9606.ENSP00000380861 | Zinc finger and BTB domain-containing protein 44; May be involved in transcriptional regulation; BTB domain containing |
| ZNF788 protein network | https://string-db.org/network/9606.ENSP00000380866 | Zinc finger family member 788 |
| RAB2B protein network | https://string-db.org/network/9606.ENSP00000380869 | Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; RAB, member RAS oncogene GTPases |
| PGBD4 protein network | https://string-db.org/network/9606.ENSP00000380872 | piggyBac transposable element derived 4; DNA transposon derived genes |
| RGS11 protein network | https://string-db.org/network/9606.ENSP00000380876 | Regulator of G-protein signaling 11; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form; Regulators [...] |
| ASCC2 protein network | https://string-db.org/network/9606.ENSP00000380877 | Activating signal cointegrator 1 complex subunit 2; Enhances NF-kappa-B, SRF and AP1 transactivation |
| PPP3CC protein network | https://string-db.org/network/9606.ENSP00000380878 | Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of [...] |
| PQLC1 protein network | https://string-db.org/network/9606.ENSP00000380880 | PQ-loop repeat-containing protein 1; PQ loop repeat containing 1 |
| MED13 protein network | https://string-db.org/network/9606.ENSP00000380888 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| COL8A2 protein network | https://string-db.org/network/9606.ENSP00000380901 | Collagen alpha-2(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the en [...] |
| ROBO3 protein network | https://string-db.org/network/9606.ENSP00000380903 | Roundabout homolog 3; Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissu [...] |
| POLR3D protein network | https://string-db.org/network/9606.ENSP00000380904 | DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| CEP83 protein network | https://string-db.org/network/9606.ENSP00000380911 | Centrosomal protein of 83 kDa; Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ci [...] |
| C19orf38 protein network | https://string-db.org/network/9606.ENSP00000380920 | Protein HIDE1; Chromosome 19 open reading frame 38 |
| SH3KBP1 protein network | https://string-db.org/network/9606.ENSP00000380921 | SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of [...] |
| TCP10 protein network | https://string-db.org/network/9606.ENSP00000380929 | T-complex protein 10A homolog; T-complex 10 |
| C12orf74 protein network | https://string-db.org/network/9606.ENSP00000380933 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 |
| ARHGEF12 protein network | https://string-db.org/network/9606.ENSP00000380942 | Rho guanine nucleotide exchange factor 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchang [...] |
| ITGB2 protein network | https://string-db.org/network/9606.ENSP00000380948 | Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component [...] |
| MBP protein network | https://string-db.org/network/9606.ENSP00000380958 | Myelin basic protein; The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its fo [...] |
| C17orf67 protein network | https://string-db.org/network/9606.ENSP00000380959 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67 |
| KIAA0020 protein network | https://string-db.org/network/9606.ENSP00000380982 | Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence spe [...] |
| KIAA1211L protein network | https://string-db.org/network/9606.ENSP00000380996 | Uncharacterized protein KIAA1211-like; KIAA1211 like |
| CHMP1A protein network | https://string-db.org/network/9606.ENSP00000380998 | Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodi [...] |
| ZNF846 protein network | https://string-db.org/network/9606.ENSP00000380999 | Zinc finger protein 846; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TTC28 protein network | https://string-db.org/network/9606.ENSP00000381003 | Tetratricopeptide repeat protein 28; During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody; Tetratricopeptide repeat domain cont [...] |
| KRTAP12-3 protein network | https://string-db.org/network/9606.ENSP00000381005 | Keratin-associated protein 12-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| NAV3 protein network | https://string-db.org/network/9606.ENSP00000381007 | Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration; Belongs to the Nav/unc-53 family |
| MUC16 protein network | https://string-db.org/network/9606.ENSP00000381008 | Mucin-16; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces; Mucins |
| KRTAP10-9 protein network | https://string-db.org/network/9606.ENSP00000381009 | Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| TRPM2 protein network | https://string-db.org/network/9606.ENSP00000381023 | Transient receptor potential cation channel subfamily M member 2; Isoform 1: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasm [...] |
| NPM2 protein network | https://string-db.org/network/9606.ENSP00000381032 | Nucleoplasmin-2; Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during [...] |
| SOCS6 protein network | https://string-db.org/network/9606.ENSP00000381034 | Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of [...] |
| ADGB protein network | https://string-db.org/network/9606.ENSP00000381036 | Androglobin; Calpains |
| C21orf2 protein network | https://string-db.org/network/9606.ENSP00000381047 | Protein C21orf2; Plays a role in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Involved in DNA damage repair |
| ZMYND11 protein network | https://string-db.org/network/9606.ENSP00000381053 | Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongati [...] |
| RNASE1 protein network | https://string-db.org/network/9606.ENSP00000381057 | Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA; Ribonuclease A family |
| CDH7 protein network | https://string-db.org/network/9606.ENSP00000381058 | Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| INTS10 protein network | https://string-db.org/network/9606.ENSP00000381064 | Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. Th [...] |
| MAP2K7 protein network | https://string-db.org/network/9606.ENSP00000381070 | Dual specificity mitogen-activated protein kinase kinase 7; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component [...] |
| SERPINB8 protein network | https://string-db.org/network/9606.ENSP00000381072 | Serpin B8; Has an important role in epithelial desmosome-mediated cell-cell adhesion; Belongs to the serpin family. Ov-serpin subfamily |
| CXorf36 protein network | https://string-db.org/network/9606.ENSP00000381086 | Deleted in autism-related protein 1; Chromosome X open reading frame 36 |
| SLC35E3 protein network | https://string-db.org/network/9606.ENSP00000381089 | Solute carrier family 35 member E3; Putative transporter; Solute carriers |
| EPHB1 protein network | https://string-db.org/network/9606.ENSP00000381097 | Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| GRIP1 protein network | https://string-db.org/network/9606.ENSP00000381098 | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners a [...] |
| SERPINB7 protein network | https://string-db.org/network/9606.ENSP00000381101 | Serpin B7; Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin; Serpin peptidase inhibitors |
| TMEM55B protein network | https://string-db.org/network/9606.ENSP00000381102 | Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol [...] |
| TM9SF4 protein network | https://string-db.org/network/9606.ENSP00000381104 | Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Regulates the assembly an [...] |
| NPS protein network | https://string-db.org/network/9606.ENSP00000381105 | Neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role (By similarity). Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium conce [...] |
| ZCWPW1 protein network | https://string-db.org/network/9606.ENSP00000381109 | Zinc finger CW-type and PWWP domain containing 1 |
| GRK4 protein network | https://string-db.org/network/9606.ENSP00000381129 | G protein-coupled receptor kinase 4; Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmod [...] |
| FGL1 protein network | https://string-db.org/network/9606.ENSP00000381133 | Fibrinogen-like protein 1; Has hepatocyte mitogenic activity; Fibrinogen C domain containing |
| AGPAT3 protein network | https://string-db.org/network/9606.ENSP00000381140 | 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Ac [...] |
| CTDSP2 protein network | https://string-db.org/network/9606.ENSP00000381148 | Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2; Preferentially catalyzes the dephosphorylation of 'Ser- 5' within the tandem 7 residue repeats in the C-terminal domai [...] |
| MBLAC1 protein network | https://string-db.org/network/9606.ENSP00000381150 | Metallo-beta-lactamase domain containing 1 |
| DYNC2H1 protein network | https://string-db.org/network/9606.ENSP00000381167 | Cytoplasmic dynein 2 heavy chain 1; May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and [...] |
| FAM153C protein network | https://string-db.org/network/9606.ENSP00000381177 | Protein FAM153C; Family with sequence similarity 153 member C; Belongs to the FAM153 family |
| C3orf56 protein network | https://string-db.org/network/9606.ENSP00000381182 | Putative uncharacterized protein C3orf56; Chromosome 3 open reading frame 56 |
| BCL2 protein network | https://string-db.org/network/9606.ENSP00000381185 | Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial [...] |
| KIAA1468 protein network | https://string-db.org/network/9606.ENSP00000381198 | LisH domain and HEAT repeat-containing protein KIAA1468; Armadillo-like helical domain containing |
| TMEM123 protein network | https://string-db.org/network/9606.ENSP00000381204 | Porimin; Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability |
| RDH16 protein network | https://string-db.org/network/9606.ENSP00000381206 | Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol t [...] |
| HPS4 protein network | https://string-db.org/network/9606.ENSP00000381213 | Hermansky-Pudlak syndrome 4 protein; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting t [...] |
| RGPD2 protein network | https://string-db.org/network/9606.ENSP00000381214 | RANBP2-like and GRIP domain-containing protein 2; Tetratricopeptide repeat domain containing |
| KHSRP protein network | https://string-db.org/network/9606.ENSP00000381216 | Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream co [...] |
| HDDC2 protein network | https://string-db.org/network/9606.ENSP00000381220 | HD domain containing 2; Belongs to the HDDC2 family |
| CBSL protein network | https://string-db.org/network/9606.ENSP00000381231 | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, [...] |
| ENSG00000274276 protein network | https://string-db.org/network/9606.ENSP00000381234 | annotation not available |
| HM13 protein network | https://string-db.org/network/9606.ENSP00000381237 | Histocompatibility minor 13 |
| EFCAB9 protein network | https://string-db.org/network/9606.ENSP00000381247 | EF-hand calcium-binding domain-containing protein 9; EF-hand calcium binding domain 9 |
| APOF protein network | https://string-db.org/network/9606.ENSP00000381250 | Apolipoprotein F; Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Als [...] |
| WDR4 protein network | https://string-db.org/network/9606.ENSP00000381266 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and [...] |
| TBC1D32 protein network | https://string-db.org/network/9606.ENSP00000381270 | Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliar [...] |
| CD200R1L protein network | https://string-db.org/network/9606.ENSP00000381272 | Cell surface glycoprotein CD200 receptor 2; May be a receptor for the CD200/OX2 cell surface glycoprotein; C2-set domain containing |
| CRYBB2 protein network | https://string-db.org/network/9606.ENSP00000381273 | Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family |
| VIMP protein network | https://string-db.org/network/9606.ENSP00000381282 | Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where [...] |
| NSF protein network | https://string-db.org/network/9606.ENSP00000381293 | Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulu [...] |
| LONRF1 protein network | https://string-db.org/network/9606.ENSP00000381298 | LON peptidase N-terminal domain and ring finger 1 |
| PPAPDC1A protein network | https://string-db.org/network/9606.ENSP00000381302 | Phospholipid phosphatase 4; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol; Belongs to the PA-phosphat [...] |
| CRHR1 protein network | https://string-db.org/network/9606.ENSP00000381333 | Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a con [...] |
| GNAT3 protein network | https://string-db.org/network/9606.ENSP00000381339 | Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in [...] |
| GGT5 protein network | https://string-db.org/network/9606.ENSP00000381340 | Glutathione hydrolase 5 proenzyme; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4); Be [...] |
| CABIN1 protein network | https://string-db.org/network/9606.ENSP00000381364 | Calcineurin-binding protein cabin-1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcine [...] |
| C15orf38-AP3S2 protein network | https://string-db.org/network/9606.ENSP00000381377 | C15orf38-AP3S2 readthrough |
| FANCB protein network | https://string-db.org/network/9606.ENSP00000381378 | Fanconi anemia group B protein; DNA repair protein required for FANCD2 ubiquitination; Fanconi anemia complementation groups |
| TCF4 protein network | https://string-db.org/network/9606.ENSP00000381382 | Transcription factor 4; Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding [...] |
| DDT protein network | https://string-db.org/network/9606.ENSP00000381386 | D-dopachrome decarboxylase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI) |
| CAMK2A protein network | https://string-db.org/network/9606.ENSP00000381412 | Calcium/calmodulin-dependent protein kinase type II subunit alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurot [...] |
| MPP3 protein network | https://string-db.org/network/9606.ENSP00000381425 | MAGUK p55 subfamily member 3; Membrane associated guanylate kinases; Belongs to the MAGUK family |
| CGGBP1 protein network | https://string-db.org/network/9606.ENSP00000381429 | CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter |
| VGLL3 protein network | https://string-db.org/network/9606.ENSP00000381436 | Transcription cofactor vestigial-like protein 3; May act as a specific coactivator for the mammalian TEFs; Vestigial like family |
| CST3 protein network | https://string-db.org/network/9606.ENSP00000381448 | Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family |
| PPME1 protein network | https://string-db.org/network/9606.ENSP00000381461 | Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion a [...] |
| HIGD1C protein network | https://string-db.org/network/9606.ENSP00000381473 | HIG1 hypoxia inducible domain family member 1C |
| TMPRSS12 protein network | https://string-db.org/network/9606.ENSP00000381476 | Transmembrane serine protease 12; Belongs to the peptidase S1 family |
| SPAG11B protein network | https://string-db.org/network/9606.ENSP00000381480 | Sperm-associated antigen 11A; Sperm associated antigen 11B; Belongs to the SPAG11 family |
| NOTO protein network | https://string-db.org/network/9606.ENSP00000381486 | Homeobox protein notochord; Transcription regulator acting downstream of both FOXA2 and Brachyury (T) during notochord development. Required for node morphogenesis. Is essential for cilia formati [...] |
| KRTAP9-1 protein network | https://string-db.org/network/9606.ENSP00000381488 | Keratin-associated protein 9-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KRTAP4-1 protein network | https://string-db.org/network/9606.ENSP00000381489 | Keratin-associated protein 4-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| LARP4 protein network | https://string-db.org/network/9606.ENSP00000381490 | La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA tr [...] |
| KRTAP2-2 protein network | https://string-db.org/network/9606.ENSP00000381494 | Keratin-associated protein 2-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| FGFRL1 protein network | https://string-db.org/network/9606.ENSP00000381498 | Fibroblast growth factor receptor-like 1; Has a negative effect on cell proliferation; I-set domain containing |
| PAX1 protein network | https://string-db.org/network/9606.ENSP00000381499 | Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal developm [...] |
| PRPS2 protein network | https://string-db.org/network/9606.ENSP00000381504 | Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase f [...] |
| STK32A protein network | https://string-db.org/network/9606.ENSP00000381535 | Serine/threonine kinase 32A |
| KRTAP5-11 protein network | https://string-db.org/network/9606.ENSP00000381541 | Keratin-associated protein 5-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which a [...] |
| KRTAP5-10 protein network | https://string-db.org/network/9606.ENSP00000381542 | Keratin-associated protein 5-10; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which a [...] |
| FRMD4B protein network | https://string-db.org/network/9606.ENSP00000381549 | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffoldin [...] |
| CCDC11 protein network | https://string-db.org/network/9606.ENSP00000381553 | Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis |
| DIAPH1 protein network | https://string-db.org/network/9606.ENSP00000381565 | Protein diaphanous homolog 1; Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates ac [...] |
| TMF1 protein network | https://string-db.org/network/9606.ENSP00000381567 | TATA element modulatory factor; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from [...] |
| USP34 protein network | https://string-db.org/network/9606.ENSP00000381577 | Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activat [...] |
| LCP1 protein network | https://string-db.org/network/9606.ENSP00000381581 | Plastin-2; Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and C [...] |
| TMPRSS2 protein network | https://string-db.org/network/9606.ENSP00000381588 | Transmembrane protease serine 2; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus- cell membrane fusions; spike proteins are synthes [...] |
| PCDHGA11 protein network | https://string-db.org/network/9606.ENSP00000381589 | Protocadherin gamma-A11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadh [...] |
| PCDHGB7 protein network | https://string-db.org/network/9606.ENSP00000381594 | Protocadherin gamma-B7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| MX1 protein network | https://string-db.org/network/9606.ENSP00000381601 | Interferon-induced GTP-binding protein Mx1; Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include neg [...] |
| PCDHGA8 protein network | https://string-db.org/network/9606.ENSP00000381605 | Protocadherin gamma-A8; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| GSTP1 protein network | https://string-db.org/network/9606.ENSP00000381607 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocatio [...] |
| PCDHGA10 protein network | https://string-db.org/network/9606.ENSP00000381611 | Protocadherin gamma-A10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadh [...] |
| ZNF596 protein network | https://string-db.org/network/9606.ENSP00000381613 | Zinc finger protein 596; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PCDHA12 protein network | https://string-db.org/network/9606.ENSP00000381628 | Protocadherin alpha-12; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| C2orf73 protein network | https://string-db.org/network/9606.ENSP00000381631 | Uncharacterized protein C2orf73; Chromosome 2 open reading frame 73 |
| PCDHA11 protein network | https://string-db.org/network/9606.ENSP00000381636 | Protocadherin alpha-11; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| HMGCLL1 protein network | https://string-db.org/network/9606.ENSP00000381654 | 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy- 3-methylglutaryl [...] |
| DOT1L protein network | https://string-db.org/network/9606.ENSP00000381657 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to [...] |
| GXYLT1 protein network | https://string-db.org/network/9606.ENSP00000381666 | Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of x [...] |
| TP53TG3 protein network | https://string-db.org/network/9606.ENSP00000381672 | TP53 target 3; May play a significant role in p53/TP53-mediating signaling pathway |
| ZSWIM8 protein network | https://string-db.org/network/9606.ENSP00000381693 | Zinc finger SWIM-type containing 8 |
| SHARPIN protein network | https://string-db.org/network/9606.ENSP00000381698 | Sharpin; Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflamm [...] |
| B3GALT5 protein network | https://string-db.org/network/9606.ENSP00000381699 | Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Ce [...] |
| DEFB113 protein network | https://string-db.org/network/9606.ENSP00000381703 | Beta-defensin 113; Has antibacterial activity; Defensins, beta |
| UBE2D2 protein network | https://string-db.org/network/9606.ENSP00000381717 | Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates [...] |
| ATP5A1 protein network | https://string-db.org/network/9606.ENSP00000381736 | ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane [...] |
| PARP3 protein network | https://string-db.org/network/9606.ENSP00000381740 | Poly [ADP-ribose] polymerase 3; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin archite [...] |
| CAPN11 protein network | https://string-db.org/network/9606.ENSP00000381758 | Calpain-11; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs to the peptidase [...] |
| IQCF6 protein network | https://string-db.org/network/9606.ENSP00000381760 | IQ motif containing F6 |
| CDH23 protein network | https://string-db.org/network/9606.ENSP00000381768 | Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing an [...] |
| TOP3B protein network | https://string-db.org/network/9606.ENSP00000381773 | DNA topoisomerase 3-beta-1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the [...] |
| TNFSF11 protein network | https://string-db.org/network/9606.ENSP00000381775 | Tumor necrosis factor ligand superfamily member 11; Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic [...] |
| SLC25A45 protein network | https://string-db.org/network/9606.ENSP00000381782 | Solute carrier family 25 member 45; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| HSDL2 protein network | https://string-db.org/network/9606.ENSP00000381785 | Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity; Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| GRB10 protein network | https://string-db.org/network/9606.ENSP00000381793 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals fro [...] |
| CCDC33 protein network | https://string-db.org/network/9606.ENSP00000381795 | Coiled-coil domain containing 33 |
| YPEL3 protein network | https://string-db.org/network/9606.ENSP00000381821 | Protein yippee-like 3; Involved in proliferation and apoptosis in myeloid precursor cells; Yippee like family |
| SEC24A protein network | https://string-db.org/network/9606.ENSP00000381823 | Protein transport protein Sec24A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| SAC3D1 protein network | https://string-db.org/network/9606.ENSP00000381824 | SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression; Belongs to the SAC3 family |
| AEBP2 protein network | https://string-db.org/network/9606.ENSP00000381840 | Zinc finger protein AEBP2; DNA-binding transcriptional repressor. May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 |
| ATL3 protein network | https://string-db.org/network/9606.ENSP00000381844 | Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular netw [...] |
| MROH6 protein network | https://string-db.org/network/9606.ENSP00000381857 | Maestro heat like repeat family member 6 |
| TOMM6 protein network | https://string-db.org/network/9606.ENSP00000381859 | Mitochondrial import receptor subunit TOM6 homolog; Translocase of outer mitochondrial membrane complex; Belongs to the Tom6 family |
| DAAM2 protein network | https://string-db.org/network/9606.ENSP00000381876 | Dishevelled associated activator of morphogenesis 2; Armadillo-like helical domain containing |
| SMCO3 protein network | https://string-db.org/network/9606.ENSP00000381895 | Single-pass membrane protein with coiled-coil domains 3 |
| MGARP protein network | https://string-db.org/network/9606.ENSP00000381928 | Protein MGARP; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hyp [...] |
| DYRK1A protein network | https://string-db.org/network/9606.ENSP00000381932 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway [...] |
| C4orf29 protein network | https://string-db.org/network/9606.ENSP00000381937 | Protein ABHD18; Chromosome 4 open reading frame 29; Belongs to the AB hydrolase superfamily |
| COL13A1 protein network | https://string-db.org/network/9606.ENSP00000381949 | Collagen alpha-1(XIII) chain; Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basemen [...] |
| MS4A4E protein network | https://string-db.org/network/9606.ENSP00000381956 | Putative membrane-spanning 4-domains subfamily A member 4E; Membrane spanning 4-domains A4E; Belongs to the MS4A family |
| KSR1 protein network | https://string-db.org/network/9606.ENSP00000381958 | Kinase suppressor of Ras 1; Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes [...] |
| SPTLC3 protein network | https://string-db.org/network/9606.ENSP00000381968 | Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) [...] |
| GIN1 protein network | https://string-db.org/network/9606.ENSP00000381970 | Gypsy retrotransposon integrase 1 |
| TTC3 protein network | https://string-db.org/network/9606.ENSP00000381981 | E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a ter [...] |
| RPRD1A protein network | https://string-db.org/network/9606.ENSP00000381984 | Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and partici [...] |
| SEPT7 protein network | https://string-db.org/network/9606.ENSP00000381992 | Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for nor [...] |
| CDRT15L2 protein network | https://string-db.org/network/9606.ENSP00000382000 | CMT1A duplicated region transcript 15 like 2 |
| CTNND1 protein network | https://string-db.org/network/9606.ENSP00000382004 | Catenin delta-1; Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulat [...] |
| LCMT1 protein network | https://string-db.org/network/9606.ENSP00000382021 | Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues |
| C4orf3 protein network | https://string-db.org/network/9606.ENSP00000382026 | Uncharacterized protein C4orf3; Chromosome 4 open reading frame 3 |
| RAD51AP2 protein network | https://string-db.org/network/9606.ENSP00000382030 | RAD51 associated protein 2 |
| POLR3G protein network | https://string-db.org/network/9606.ENSP00000382058 | DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripher [...] |
| HLCS protein network | https://string-db.org/network/9606.ENSP00000382071 | Biotin--protein ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl [...] |
| COL25A1 protein network | https://string-db.org/network/9606.ENSP00000382083 | Collagen alpha-1(XXV) chain; Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds [...] |
| EVPLL protein network | https://string-db.org/network/9606.ENSP00000382086 | Envoplakin-like protein; Envoplakin like; Belongs to the plakin or cytolinker family |
| CLDN14 protein network | https://string-db.org/network/9606.ENSP00000382090 | Claudin-14; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Belongs to the claudin family |
| ALKBH5 protein network | https://string-db.org/network/9606.ENSP00000382091 | RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messeng [...] |
| DCDC2C protein network | https://string-db.org/network/9606.ENSP00000382097 | Doublecortin domain containing 2C |
| DOPEY2 protein network | https://string-db.org/network/9606.ENSP00000382104 | Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes; Belongs to the dopey family |
| AIFM3 protein network | https://string-db.org/network/9606.ENSP00000382120 | Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential |
| LRRC48 protein network | https://string-db.org/network/9606.ENSP00000382140 | Dynein regulatory complex subunit 3; Key component of the nexin-dynein regulatory complex (N- DRC), a key regulator of ciliary motility |
| SETD4 protein network | https://string-db.org/network/9606.ENSP00000382163 | Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family |
| MYO5A protein network | https://string-db.org/network/9606.ENSP00000382177 | Unconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates th [...] |
| MDGA2 protein network | https://string-db.org/network/9606.ENSP00000382178 | MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions; I-set domain containing |
| JMJD1C protein network | https://string-db.org/network/9606.ENSP00000382204 | Probable JmjC domain-containing histone demethylation protein 2C; Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code [...] |
| DSPP protein network | https://string-db.org/network/9606.ENSP00000382213 | Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regula [...] |
| ZSWIM7 protein network | https://string-db.org/network/9606.ENSP00000382218 | Zinc finger SWIM domain-containing protein 7; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced [...] |
| FAM165B protein network | https://string-db.org/network/9606.ENSP00000382234 | Small integral membrane protein 11; Belongs to the SMIM11 family |
| TMEM26 protein network | https://string-db.org/network/9606.ENSP00000382237 | Transmembrane protein 26 |
| RBM12B protein network | https://string-db.org/network/9606.ENSP00000382239 | RNA binding motif protein 12B |
| QSER1 protein network | https://string-db.org/network/9606.ENSP00000382241 | Glutamine and serine rich 1 |
| MRPS6 protein network | https://string-db.org/network/9606.ENSP00000382250 | Mitochondrial ribosomal protein S6 |
| HECTD1 protein network | https://string-db.org/network/9606.ENSP00000382269 | E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquiti [...] |
| NOMO3 protein network | https://string-db.org/network/9606.ENSP00000382274 | Nodal modulator 3; May antagonize Nodal signaling |
| OTOG protein network | https://string-db.org/network/9606.ENSP00000382323 | Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule [...] |
| SDR39U1 protein network | https://string-db.org/network/9606.ENSP00000382327 | Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily |
| N4BP2L2 protein network | https://string-db.org/network/9606.ENSP00000382328 | NEDD4 binding protein 2 like 2 |
| RNF222 protein network | https://string-db.org/network/9606.ENSP00000382330 | Ring finger protein 222 |
| PSG5 protein network | https://string-db.org/network/9606.ENSP00000382334 | Pregnancy specific beta-1-glycoprotein 5; Belongs to the immunoglobulin superfamily. CEA family |
| RABGGTA protein network | https://string-db.org/network/9606.ENSP00000382341 | Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence - [...] |
| ABCC1 protein network | https://string-db.org/network/9606.ENSP00000382342 | Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene [...] |
| ACSM4 protein network | https://string-db.org/network/9606.ENSP00000382349 | Acyl-coenzyme A synthetase ACSM4, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspon [...] |
| COL28A1 protein network | https://string-db.org/network/9606.ENSP00000382356 | Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family |
| ANKRD28 protein network | https://string-db.org/network/9606.ENSP00000382379 | Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein su [...] |
| NEURL4 protein network | https://string-db.org/network/9606.ENSP00000382390 | Neuralized-like protein 4; Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing form [...] |
| MAP3K1 protein network | https://string-db.org/network/9606.ENSP00000382423 | Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May [...] |
| DLG4 protein network | https://string-db.org/network/9606.ENSP00000382428 | Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. [...] |
| PLA2G4E protein network | https://string-db.org/network/9606.ENSP00000382434 | Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position; C2 domain containing phospholipases |
| C22orf39 protein network | https://string-db.org/network/9606.ENSP00000382474 | UPF0545 protein C22orf39; Chromosome 22 open reading frame 39; Belongs to the UPF0545 family |
| MROH2B protein network | https://string-db.org/network/9606.ENSP00000382476 | Maestro heat-like repeat-containing protein family member 2B; May play a role in the process of sperm capacitation; Maestro heat like repeat containing |
| PROL1 protein network | https://string-db.org/network/9606.ENSP00000382485 | Opiorphin prepropeptide; Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC( [...] |
| RADIL protein network | https://string-db.org/network/9606.ENSP00000382492 | Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development; Belongs to the RADIL famil [...] |
| UBXN2B protein network | https://string-db.org/network/9606.ENSP00000382507 | UBX domain-containing protein 2B; Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their r [...] |
| CDIP1 protein network | https://string-db.org/network/9606.ENSP00000382508 | Cell death-inducing p53-target protein 1; Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner |
| ZNF195 protein network | https://string-db.org/network/9606.ENSP00000382511 | Zinc finger protein 195; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF594 protein network | https://string-db.org/network/9606.ENSP00000382513 | Zinc finger protein 594; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SRL protein network | https://string-db.org/network/9606.ENSP00000382518 | Sarcalumenin; May be involved in the regulation of calcium transport |
| TSSK2 protein network | https://string-db.org/network/9606.ENSP00000382544 | Testis-specific serine/threonine-protein kinase 2; Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in [...] |
| KRTAP5-5 protein network | https://string-db.org/network/9606.ENSP00000382584 | Keratin-associated protein 5-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| KRTAP5-4 protein network | https://string-db.org/network/9606.ENSP00000382590 | Keratin associated protein 5-4 |
| KRTAP5-3 protein network | https://string-db.org/network/9606.ENSP00000382592 | Keratin-associated protein 5-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| PAICS protein network | https://string-db.org/network/9606.ENSP00000382595 | Multifunctional protein ADE2; Phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase famil [...] |
| ANKRD18A protein network | https://string-db.org/network/9606.ENSP00000382610 | Ankyrin repeat domain-containing protein 18A; Ankyrin repeat domain containing |
| RBBP8 protein network | https://string-db.org/network/9606.ENSP00000382628 | DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double- strand break (DSB) repair through the homologous recomb [...] |
| FAM166B protein network | https://string-db.org/network/9606.ENSP00000382646 | Protein FAM166B; Family with sequence similarity 166 member B |
| GRXCR1 protein network | https://string-db.org/network/9606.ENSP00000382670 | Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Glutaredoxin domain containing |
| ENHO protein network | https://string-db.org/network/9606.ENSP00000382675 | Adropin; Involved in the regulation of glucose homeostasis and lipid metabolism |
| MRAP protein network | https://string-db.org/network/9606.ENSP00000382684 | Melanocortin-2 receptor accessory protein; Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing gen [...] |
| KDM5A protein network | https://string-db.org/network/9606.ENSP00000382688 | Lysine-specific demethylase 5A; Histone demethylase that specifically demethylates 'Lys- 4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', [...] |
| ROCK1 protein network | https://string-db.org/network/9606.ENSP00000382697 | Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organizat [...] |
| IFITM3 protein network | https://string-db.org/network/9606.ENSP00000382707 | Interferon-induced transmembrane protein 3; IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by prevent [...] |
| C5orf49 protein network | https://string-db.org/network/9606.ENSP00000382708 | Uncharacterized protein C5orf49; Chromosome 5 open reading frame 49 |
| UBE2QL1 protein network | https://string-db.org/network/9606.ENSP00000382713 | Ubiquitin-conjugating enzyme E2Q-like protein 1; Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination [...] |
| WDR19 protein network | https://string-db.org/network/9606.ENSP00000382717 | WD repeat-containing protein 19; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Involved in cilia function and/or assembly (By similarity). Associate [...] |
| CECR1 protein network | https://string-db.org/network/9606.ENSP00000382731 | Adenosine deaminase 2; Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated [...] |
| SEL1L3 protein network | https://string-db.org/network/9606.ENSP00000382767 | Protein sel-1 homolog 3; SEL1L family member 3 |
| KCNU1 protein network | https://string-db.org/network/9606.ENSP00000382770 | Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatoz [...] |
| KRTAP13-2 protein network | https://string-db.org/network/9606.ENSP00000382777 | Keratin-associated protein 13-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| SEH1L protein network | https://string-db.org/network/9606.ENSP00000382779 | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex i [...] |
| CLDN8 protein network | https://string-db.org/network/9606.ENSP00000382783 | Claudin-8; Tight-junction protein required for paracellular chloride transport in the kidney. Mediates recruitment of CLDN4 to tight junction in the kidney. Claudins play a major role in tight ju [...] |
| GRIK1 protein network | https://string-db.org/network/9606.ENSP00000382791 | Glutamate receptor ionotropic, kainate 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitato [...] |
| RNF212B protein network | https://string-db.org/network/9606.ENSP00000382794 | Ring finger protein 212B |
| RUNX3 protein network | https://string-db.org/network/9606.ENSP00000382800 | Runt-related transcription factor 3; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor en [...] |
| ODF3B protein network | https://string-db.org/network/9606.ENSP00000382804 | Outer dense fiber of sperm tails 3B |
| BACH1 protein network | https://string-db.org/network/9606.ENSP00000382805 | Transcription regulator protein BACH1; Transcriptional regulator that acts as repressor or activator. Binds, in vitro, to NF-E2 binding sites. Play important roles in coordinating transcription a [...] |
| ITFG3 protein network | https://string-db.org/network/9606.ENSP00000382814 | Protein FAM234A; Integrin alpha FG-GAP repeat containing 3; Belongs to the FAM234 family |
| KIAA2026 protein network | https://string-db.org/network/9606.ENSP00000382815 | Uncharacterized protein KIAA2026; KIAA2026 |
| MAP3K7CL protein network | https://string-db.org/network/9606.ENSP00000382828 | MAP3K7 C-terminal-like protein; MAP3K7 C-terminal like |
| DDX3X protein network | https://string-db.org/network/9606.ENSP00000382840 | ATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate spec [...] |
| MTRNR2L4 protein network | https://string-db.org/network/9606.ENSP00000382856 | Humanin-like 4; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| CHD8 protein network | https://string-db.org/network/9606.ENSP00000382863 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structu [...] |
| MAGEB16 protein network | https://string-db.org/network/9606.ENSP00000382871 | Melanoma-associated antigen B16; MAGE family member B16 |
| MAGEB17 protein network | https://string-db.org/network/9606.ENSP00000382884 | Melanoma-associated antigen B17; MAGE family member B17 |
| RPGRIP1 protein network | https://string-db.org/network/9606.ENSP00000382895 | X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Re [...] |
| SIRPA protein network | https://string-db.org/network/9606.ENSP00000382941 | Tyrosine-protein phosphatase non-receptor type substrate 1; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other bindin [...] |
| DEFB30 protein network | https://string-db.org/network/9606.ENSP00000382951 | Defensin, beta 130; Antimicrobial host-defense peptide. Has an antiplasmodial activity |
| SNRPN protein network | https://string-db.org/network/9606.ENSP00000382972 | Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events; Sm spliceosomal proteins |
| L3MBTL4 protein network | https://string-db.org/network/9606.ENSP00000382976 | Lethal(3)malignant brain tumor-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...] |
| TUBA3C protein network | https://string-db.org/network/9606.ENSP00000382982 | Tubulin alpha-3C/D chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alph [...] |
| FKBP1A protein network | https://string-db.org/network/9606.ENSP00000383003 | Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of l [...] |
| ZNF705G protein network | https://string-db.org/network/9606.ENSP00000383020 | Putative zinc finger protein 705G; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MYL5 protein network | https://string-db.org/network/9606.ENSP00000383023 | Myosin light chain 5; EF-hand domain containing |
| KDM1A protein network | https://string-db.org/network/9606.ENSP00000383042 | Lysine-specific histone demethylase 1A; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending [...] |
| USP25 protein network | https://string-db.org/network/9606.ENSP00000383044 | Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycl [...] |
| ARGLU1 protein network | https://string-db.org/network/9606.ENSP00000383059 | Arginine and glutamate-rich protein 1; Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 |
| NRIP1 protein network | https://string-db.org/network/9606.ENSP00000383063 | Nuclear receptor-interacting protein 1; Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone recep [...] |
| TPTE2 protein network | https://string-db.org/network/9606.ENSP00000383089 | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2; Transmembrane phosphoinositide 3-phosphatase and tensin homolog 2; C2 tensin-type domain containing |
| HGNC:9979 protein network | https://string-db.org/network/9606.ENSP00000383096 | Ret finger protein-like 2 |
| DEPDC5 protein network | https://string-db.org/network/9606.ENSP00000383105 | GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydro [...] |
| COLEC12 protein network | https://string-db.org/network/9606.ENSP00000383115 | Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the r [...] |
| CDC42 protein network | https://string-db.org/network/9606.ENSP00000383118 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of e [...] |
| SLITRK6 protein network | https://string-db.org/network/9606.ENSP00000383143 | SLIT and NTRK-like protein 6; Regulator of neurite outgrowth required for normal hearing and vision; Belongs to the SLITRK family |
| SFI1 protein network | https://string-db.org/network/9606.ENSP00000383145 | Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2; Belongs to the SFI1 family |
| PCBP3 protein network | https://string-db.org/network/9606.ENSP00000383168 | Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC |
| DIAPH3 protein network | https://string-db.org/network/9606.ENSP00000383178 | Protein diaphanous homolog 3; Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is req [...] |
| MACC1 protein network | https://string-db.org/network/9606.ENSP00000383185 | Metastasis-associated in colon cancer protein 1; Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth [...] |
| NEDD4L protein network | https://string-db.org/network/9606.ENSP00000383199 | E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiq [...] |
| SGSM1 protein network | https://string-db.org/network/9606.ENSP00000383212 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and R [...] |
| KRTAP10-12 protein network | https://string-db.org/network/9606.ENSP00000383216 | Keratin-associated protein 10-12; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-6 protein network | https://string-db.org/network/9606.ENSP00000383219 | Keratin-associated protein 10-6; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-5 protein network | https://string-db.org/network/9606.ENSP00000383223 | Keratin-associated protein 10-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-4 protein network | https://string-db.org/network/9606.ENSP00000383225 | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| KRTAP10-1 protein network | https://string-db.org/network/9606.ENSP00000383226 | Keratin-associated protein 10-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| GGT1 protein network | https://string-db.org/network/9606.ENSP00000383232 | Glutathione hydrolase 1 proenzyme; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of [...] |
| MAPK4 protein network | https://string-db.org/network/9606.ENSP00000383234 | Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still uncl [...] |
| SIAH3 protein network | https://string-db.org/network/9606.ENSP00000383256 | Seven in absentia homolog 3; Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depol [...] |
| SMIM2 protein network | https://string-db.org/network/9606.ENSP00000383270 | Small integral membrane protein 2 |
| EIF4G3 protein network | https://string-db.org/network/9606.ENSP00000383274 | Eukaryotic translation initiation factor 4 gamma 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal s [...] |
| NBEA protein network | https://string-db.org/network/9606.ENSP00000383295 | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By sim [...] |
| DSCAM protein network | https://string-db.org/network/9606.ENSP00000383303 | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the sa [...] |
| MORC3 protein network | https://string-db.org/network/9606.ENSP00000383333 | MORC family CW-type zinc finger protein 3; Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP5 [...] |
| PLA2G2A protein network | https://string-db.org/network/9606.ENSP00000383364 | Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metaboli [...] |
| TXNRD2 protein network | https://string-db.org/network/9606.ENSP00000383365 | Thioredoxin reductase 2, mitochondrial; Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling; Belongs [...] |
| EFCAB8 protein network | https://string-db.org/network/9606.ENSP00000383366 | EF-hand calcium-binding domain-containing protein 8; EF-hand calcium binding domain 8 |
| JAM2 protein network | https://string-db.org/network/9606.ENSP00000383376 | Junctional adhesion molecule B; May play a role in the processes of lymphocyte homing to secondary lymphoid organs; Belongs to the immunoglobulin superfamily |
| GP1BB protein network | https://string-db.org/network/9606.ENSP00000383382 | Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to [...] |
| NCAM2 protein network | https://string-db.org/network/9606.ENSP00000383392 | Neural cell adhesion molecule 2; May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons; Fibronectin type III domain containing |
| DEFB116 protein network | https://string-db.org/network/9606.ENSP00000383396 | Beta-defensin 116; Has antibacterial activity; Defensins, beta |
| DEFB115 protein network | https://string-db.org/network/9606.ENSP00000383398 | Beta-defensin 115; Has antibacterial activity; Defensins, beta |
| PPP4R1 protein network | https://string-db.org/network/9606.ENSP00000383402 | Serine/threonine-protein phosphatase 4 regulatory subunit 1; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The P [...] |
| RBM11 protein network | https://string-db.org/network/9606.ENSP00000383421 | Splicing regulator RBM11; Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-media [...] |
| GAB4 protein network | https://string-db.org/network/9606.ENSP00000383431 | GRB2 associated binding protein family member 4; Belongs to the GAB family |
| C9orf152 protein network | https://string-db.org/network/9606.ENSP00000383456 | Uncharacterized protein C9orf152; Chromosome 9 open reading frame 152 |
| KLHDC7A protein network | https://string-db.org/network/9606.ENSP00000383505 | Kelch domain containing 7A |
| HMX1 protein network | https://string-db.org/network/9606.ENSP00000383516 | Homeobox protein HMX1; DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May pla [...] |
| GCGR protein network | https://string-db.org/network/9606.ENSP00000383558 | Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose produ [...] |
| ZG16 protein network | https://string-db.org/network/9606.ENSP00000383563 | Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) an [...] |
| TMEM242 protein network | https://string-db.org/network/9606.ENSP00000383594 | Transmembrane protein 242; Belongs to the TMEM242 family |
| WDR47 protein network | https://string-db.org/network/9606.ENSP00000383599 | WD repeat-containing protein 47; WD repeat domain containing |
| CCNL2 protein network | https://string-db.org/network/9606.ENSP00000383611 | Cyclin-L2; Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors; Cyclins |
| CRLF2 protein network | https://string-db.org/network/9606.ENSP00000383641 | Cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activat [...] |
| FAM72D protein network | https://string-db.org/network/9606.ENSP00000383682 | Protein FAM72D; Family with sequence similarity 72 member D |
| MASP2 protein network | https://string-db.org/network/9606.ENSP00000383690 | Mannan-binding lectin serine protease 2; Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic clea [...] |
| CENPS-CORT protein network | https://string-db.org/network/9606.ENSP00000383692 | APITD1-CORT readthrough |
| SLC2A7 protein network | https://string-db.org/network/9606.ENSP00000383698 | Solute carrier family 2, facilitated glucose transporter member 7; High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose; Solute carriers |
| C1orf86 protein network | https://string-db.org/network/9606.ENSP00000383710 | Fanconi anemia core complex-associated protein 20; Chromosome 1 open reading frame 86 |
| ENSG00000272980 protein network | https://string-db.org/network/9606.ENSP00000383715 | C-C chemokine receptor type 6; Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is [...] |
| UBE2J2 protein network | https://string-db.org/network/9606.ENSP00000383719 | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endopl [...] |
| DNAH14 protein network | https://string-db.org/network/9606.ENSP00000383737 | Dynein axonemal heavy chain 14 |
| CCDC18 protein network | https://string-db.org/network/9606.ENSP00000383808 | Coiled-coil domain containing 18 |
| MIER1 protein network | https://string-db.org/network/9606.ENSP00000383820 | Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a [...] |
| MMACHC protein network | https://string-db.org/network/9606.ENSP00000383840 | Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also [...] |
| KIAA1522 protein network | https://string-db.org/network/9606.ENSP00000383851 | Uncharacterized protein KIAA1522; KIAA1522 |
| SZRD1 protein network | https://string-db.org/network/9606.ENSP00000383866 | SUZ RNA binding domain containing 1 |
| TTC34 protein network | https://string-db.org/network/9606.ENSP00000383873 | Tetratricopeptide repeat domain containing |
| MATN3 protein network | https://string-db.org/network/9606.ENSP00000383894 | Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks; Matrilins |
| LIPK protein network | https://string-db.org/network/9606.ENSP00000383900 | Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lip [...] |
| LIPM protein network | https://string-db.org/network/9606.ENSP00000383901 | Lipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Bel [...] |
| DMRTA2 protein network | https://string-db.org/network/9606.ENSP00000383909 | Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development |
| UBAC2 protein network | https://string-db.org/network/9606.ENSP00000383911 | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets; Rhomboid family |
| ASXL2 protein network | https://string-db.org/network/9606.ENSP00000383920 | Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive s [...] |
| ZNF610 protein network | https://string-db.org/network/9606.ENSP00000383922 | Zinc finger protein 610; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LIPN protein network | https://string-db.org/network/9606.ENSP00000383923 | Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers; Lip [...] |
| GP5 protein network | https://string-db.org/network/9606.ENSP00000383931 | Platelet glycoprotein V; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces [...] |
| FAM19A5 protein network | https://string-db.org/network/9606.ENSP00000383933 | Protein FAM19A5; Family with sequence similarity 19 member A5, C-C motif chemokine like; Belongs to the FAM19/TAFA family |
| CRELD2 protein network | https://string-db.org/network/9606.ENSP00000383938 | Cysteine rich with EGF like domains 2 |
| NHP2L1 protein network | https://string-db.org/network/9606.ENSP00000383949 | NHP2-like protein 1; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding |
| MTA3 protein network | https://string-db.org/network/9606.ENSP00000383973 | Metastasis-associated protein MTA3; Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and [...] |
| CDCA7L protein network | https://string-db.org/network/9606.ENSP00000383986 | Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the pr [...] |
| ZNF681 protein network | https://string-db.org/network/9606.ENSP00000384000 | Zinc finger protein 681; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| POU6F2 protein network | https://string-db.org/network/9606.ENSP00000384004 | POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the [...] |
| CARF protein network | https://string-db.org/network/9606.ENSP00000384006 | Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calci [...] |
| SUN1 protein network | https://string-db.org/network/9606.ENSP00000384015 | SUN domain-containing protein 1; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nuc [...] |
| NCOR2 protein network | https://string-db.org/network/9606.ENSP00000384018 | Nuclear receptor corepressor 2; Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access [...] |
| CCDC85A protein network | https://string-db.org/network/9606.ENSP00000384040 | Coiled-coil domain containing 85A; Belongs to the CCDC85 family |
| PAXIP1 protein network | https://string-db.org/network/9606.ENSP00000384048 | PAX-interacting protein 1; Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. Plays a role in early development. In DNA damage re [...] |
| CSF2RB protein network | https://string-db.org/network/9606.ENSP00000384053 | Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor; CD molecules |
| TXNRD3NB protein network | https://string-db.org/network/9606.ENSP00000384071 | Protein TXNRD3NB; Thioredoxin reductase 3 neighbor |
| EFR3B protein network | https://string-db.org/network/9606.ENSP00000384081 | Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphat [...] |
| DTNB protein network | https://string-db.org/network/9606.ENSP00000384084 | Dystrobrevin beta; Zinc fingers ZZ-type; Belongs to the dystrophin family. Dystrobrevin subfamily |
| POMC protein network | https://string-db.org/network/9606.ENSP00000384092 | Pro-opiomelanocortin; Met-enkephalin: Endogenous opiate; Belongs to the POMC family |
| VSTM2A protein network | https://string-db.org/network/9606.ENSP00000384103 | V-set and transmembrane domain-containing protein 2A; Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of pre [...] |
| CUL4B protein network | https://string-db.org/network/9606.ENSP00000384109 | Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The funct [...] |
| MEI1 protein network | https://string-db.org/network/9606.ENSP00000384115 | Meiosis inhibitor protein 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity); Armadillo-l [...] |
| LRRC32 protein network | https://string-db.org/network/9606.ENSP00000384126 | Leucine-rich repeat-containing protein 32; Leucine rich repeat containing 32 |
| RDX protein network | https://string-db.org/network/9606.ENSP00000384136 | Radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane; Deafness associated genes |
| RBM33 protein network | https://string-db.org/network/9606.ENSP00000384160 | RNA-binding protein 33; RNA binding motif containing |
| KIF16B protein network | https://string-db.org/network/9606.ENSP00000384164 | Kinesin-like protein KIF16B; Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early [...] |
| FBLN2 protein network | https://string-db.org/network/9606.ENSP00000384169 | Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN; Fibulins |
| ZFPM2 protein network | https://string-db.org/network/9606.ENSP00000384179 | Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential dur [...] |
| SCFD2 protein network | https://string-db.org/network/9606.ENSP00000384182 | Sec1 family domain-containing protein 2; May be involved in protein transport |
| GATSL3 protein network | https://string-db.org/network/9606.ENSP00000384183 | Cytosolic arginine sensor for mTORC1 subunit 1; Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer [...] |
| RASGRP3 protein network | https://string-db.org/network/9606.ENSP00000384192 | Ras guanyl-releasing protein 3; Guanine nucleotide exchange factor (GEF) for Ras and Rap1; EF-hand domain containing |
| CADM2 protein network | https://string-db.org/network/9606.ENSP00000384193 | Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organ [...] |
| PDZRN4 protein network | https://string-db.org/network/9606.ENSP00000384197 | PDZ domain containing ring finger 4 |
| INO80D protein network | https://string-db.org/network/9606.ENSP00000384198 | INO80 complex subunit D; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; Belongs [...] |
| PSME4 protein network | https://string-db.org/network/9606.ENSP00000384211 | Proteasome activator complex subunit 4; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core hi [...] |
| IL18BP protein network | https://string-db.org/network/9606.ENSP00000384212 | Interleukin-18-binding protein; Isoform A binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response; Immunoglobulin like domain containing |
| GAGE12D protein network | https://string-db.org/network/9606.ENSP00000384214 | G antigen 12D; Belongs to the GAGE family |
| WWC2 protein network | https://string-db.org/network/9606.ENSP00000384222 | Protein WWC2; WW and C2 domain containing 2 |
| ECE2 protein network | https://string-db.org/network/9606.ENSP00000384223 | Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, p [...] |
| TMEM196 protein network | https://string-db.org/network/9606.ENSP00000384234 | Transmembrane protein 196 |
| ATG4B protein network | https://string-db.org/network/9606.ENSP00000384259 | Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABAR [...] |
| HPSE protein network | https://string-db.org/network/9606.ENSP00000384262 | Heparanase; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and [...] |
| CNGA1 protein network | https://string-db.org/network/9606.ENSP00000384264 | cGMP-gated cation channel alpha-1; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to [...] |
| RELA protein network | https://string-db.org/network/9606.ENSP00000384273 | Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a v [...] |
| C17orf51 protein network | https://string-db.org/network/9606.ENSP00000384286 | Uncharacterized protein C17orf51; Chromosome 17 open reading frame 51 |
| WDR60 protein network | https://string-db.org/network/9606.ENSP00000384290 | WD repeat-containing protein 60; May play a role in ciliogenesis; WD repeat domain containing |
| ACY1 protein network | https://string-db.org/network/9606.ENSP00000384296 | Aminoacylase-1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate); Belongs to the peptidase M20A family |
| WDR43 protein network | https://string-db.org/network/9606.ENSP00000384302 | WD repeat-containing protein 43; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I; [...] |
| TRIOBP protein network | https://string-db.org/network/9606.ENSP00000384312 | TRIO and F-actin-binding protein; May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formatio [...] |
| MYH8 protein network | https://string-db.org/network/9606.ENSP00000384330 | Myosin-8; Muscle contraction; Myosin heavy chains |
| CEBPZOS protein network | https://string-db.org/network/9606.ENSP00000384331 | Protein CEBPZOS; CEBPZ opposite strand |
| MEIG1 protein network | https://string-db.org/network/9606.ENSP00000384334 | Meiosis expressed gene 1 protein homolog; Essential for spermiogenesis |
| APOBEC3A protein network | https://string-db.org/network/9606.ENSP00000384359 | DNA dC->dU-editing enzyme APOBEC-3A; DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity agains [...] |
| GDPD3 protein network | https://string-db.org/network/9606.ENSP00000384363 | Lysophospholipase D GDPD3; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl-sn-glycero-3-phosphocholine (l [...] |
| NPY protein network | https://string-db.org/network/9606.ENSP00000384364 | Pro-neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family |
| KCTD1 protein network | https://string-db.org/network/9606.ENSP00000384367 | BTB/POZ domain-containing protein KCTD1; May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent |
| METTL15 protein network | https://string-db.org/network/9606.ENSP00000384369 | Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase |
| STEAP1B protein network | https://string-db.org/network/9606.ENSP00000384370 | STEAP family member 1B; Belongs to the STEAP family |
| BCL6 protein network | https://string-db.org/network/9606.ENSP00000384371 | B-cell lymphoma 6 protein; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the l [...] |
| TDRD15 protein network | https://string-db.org/network/9606.ENSP00000384376 | Tudor domain containing 15 |
| HCRTR1 protein network | https://string-db.org/network/9606.ENSP00000384387 | Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response [...] |
| MEX3D protein network | https://string-db.org/network/9606.ENSP00000384398 | RNA-binding protein MEX3D; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins |
| CHKB protein network | https://string-db.org/network/9606.ENSP00000384400 | Choline/ethanolamine kinase; Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choli [...] |
| PARG protein network | https://string-db.org/network/9606.ENSP00000384408 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG acts both as an endo- a [...] |
| TFIP11 protein network | https://string-db.org/network/9606.ENSP00000384421 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in tw [...] |
| ZGLP1 protein network | https://string-db.org/network/9606.ENSP00000384434 | GATA-type zinc finger protein 1; Transcriptional repressor that plays a central role in somatic cells of the gonad and is required for germ cell development. Able to repress GATA transcription fa [...] |
| CDK11A protein network | https://string-db.org/network/9606.ENSP00000384442 | Cyclin dependent kinase 11A |
| HYPK protein network | https://string-db.org/network/9606.ENSP00000384474 | Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in Neuro2a neuronal cells. Requi [...] |
| IFRD1 protein network | https://string-db.org/network/9606.ENSP00000384477 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that at [...] |
| CBX6 protein network | https://string-db.org/network/9606.ENSP00000384490 | Chromobox protein homolog 6; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| RASSF8 protein network | https://string-db.org/network/9606.ENSP00000384491 | Ras association domain family member 8 |
| PARVB protein network | https://string-db.org/network/9606.ENSP00000384515 | Beta-parvin; Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorg [...] |
| ARNTL protein network | https://string-db.org/network/9606.ENSP00000384517 | Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system [...] |
| ETV2 protein network | https://string-db.org/network/9606.ENSP00000384524 | ETS translocation variant 2; Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; ETS transcription factor family |
| ZBTB40 protein network | https://string-db.org/network/9606.ENSP00000384527 | Zinc finger and BTB domain-containing protein 40; May be involved in transcriptional regulation; BTB domain containing |
| AKAP12 protein network | https://string-db.org/network/9606.ENSP00000384537 | A-kinase anchor protein 12; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC); A-kinase anchoring proteins |
| BTBD3 protein network | https://string-db.org/network/9606.ENSP00000384545 | BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopica [...] |
| NXPH1 protein network | https://string-db.org/network/9606.ENSP00000384551 | Neurexophilin-1; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors |
| OR6B2 protein network | https://string-db.org/network/9606.ENSP00000384563 | Olfactory receptor 6B2; Odorant receptor; Olfactory receptors, family 6 |
| SELM protein network | https://string-db.org/network/9606.ENSP00000384564 | May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation |
| CARD10 protein network | https://string-db.org/network/9606.ENSP00000384570 | Caspase recruitment domain-containing protein 10; Activates NF-kappa-B via BCL10 and IKK; Caspase recruitment domain containing |
| GPR98 protein network | https://string-db.org/network/9606.ENSP00000384582 | G-protein coupled receptor 98; Receptor that may have an important role in the development of the central nervous system; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily |
| CYP4F11 protein network | https://string-db.org/network/9606.ENSP00000384588 | Phylloquinone omega-hydroxylase CYP4F11; Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabo [...] |
| GAREML protein network | https://string-db.org/network/9606.ENSP00000384593 | GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway |
| GTF2A1L protein network | https://string-db.org/network/9606.ENSP00000384597 | TFIIA-alpha and beta-like factor; May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows [...] |
| FAM150B protein network | https://string-db.org/network/9606.ENSP00000384604 | ALK and LTK ligand 2; Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation |
| PNPLA7 protein network | https://string-db.org/network/9606.ENSP00000384610 | Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy; Patatin like [...] |
| STON1 protein network | https://string-db.org/network/9606.ENSP00000384615 | Stonin-1; May be involved in the endocytic machinery |
| MFSD7 protein network | https://string-db.org/network/9606.ENSP00000384616 | Major facilitator superfamily domain containing 7 |
| NRG1 protein network | https://string-db.org/network/9606.ENSP00000384620 | Pro-neuregulin-1, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine [...] |
| DQX1 protein network | https://string-db.org/network/9606.ENSP00000384621 | ATP-dependent RNA helicase DQX1; DEAQ-box RNA dependent ATPase 1 |
| NLK protein network | https://string-db.org/network/9606.ENSP00000384625 | Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canon [...] |
| SETD8 protein network | https://string-db.org/network/9606.ENSP00000384629 | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K [...] |
| CTNNA2 protein network | https://string-db.org/network/9606.ENSP00000384638 | Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphologica [...] |
| MTMR3 protein network | https://string-db.org/network/9606.ENSP00000384651 | Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bi [...] |
| KIAA1210 protein network | https://string-db.org/network/9606.ENSP00000384670 | Acrosomal protein KIAA1210; KIAA1210 |
| RNASE9 protein network | https://string-db.org/network/9606.ENSP00000384683 | Inactive ribonuclease-like protein 9; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family |
| MMD2 protein network | https://string-db.org/network/9606.ENSP00000384690 | Monocyte to macrophage differentiation associated 2; Progestin and adipoQ receptor family |
| PAPOLB protein network | https://string-db.org/network/9606.ENSP00000384700 | poly(A) polymerase beta |
| FSHR protein network | https://string-db.org/network/9606.ENSP00000384708 | Follicle-stimulating hormone receptor; Receptor for follicle-stimulating hormone or follitropin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Induces [...] |
| ZDHHC8 protein network | https://string-db.org/network/9606.ENSP00000384716 | Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 s [...] |
| VSNL1 protein network | https://string-db.org/network/9606.ENSP00000384719 | Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family |
| PRDM6 protein network | https://string-db.org/network/9606.ENSP00000384725 | Putative histone-lysine N-methyltransferase PRDM6; Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from diffe [...] |
| DERL3 protein network | https://string-db.org/network/9606.ENSP00000384744 | Derlin-3; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel [...] |
| TMEM79 protein network | https://string-db.org/network/9606.ENSP00000384748 | Transmembrane protein 79; Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial c [...] |
| SLC8A1 protein network | https://string-db.org/network/9606.ENSP00000384763 | Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) leve [...] |
| RSPH10B2 protein network | https://string-db.org/network/9606.ENSP00000384766 | Radial spoke head 10 homolog B2 |
| PSG4 protein network | https://string-db.org/network/9606.ENSP00000384770 | Pregnancy specific beta-1-glycoprotein 4 |
| WDR62 protein network | https://string-db.org/network/9606.ENSP00000384792 | WD repeat-containing protein 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration. Plays a role in mother-centriole-dependent centriole duplication [...] |
| A4GALT protein network | https://string-db.org/network/9606.ENSP00000384794 | Lactosylceramide 4-alpha-galactosyltransferase; Necessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceram [...] |
| FBXO11 protein network | https://string-db.org/network/9606.ENSP00000384823 | F-box only protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degrada [...] |
| FAM104A protein network | https://string-db.org/network/9606.ENSP00000384832 | Protein FAM104A; Family with sequence similarity 104 member A |
| PRR5 protein network | https://string-db.org/network/9606.ENSP00000384848 | Proline-rich protein 5; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be [...] |
| CDKN1A protein network | https://string-db.org/network/9606.ENSP00000384849 | Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, p [...] |
| ESRRA protein network | https://string-db.org/network/9606.ENSP00000384851 | Steroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase ( [...] |
| XPO1 protein network | https://string-db.org/network/9606.ENSP00000384863 | Exportin-1; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperative [...] |
| C6orf203 protein network | https://string-db.org/network/9606.ENSP00000384867 | Uncharacterized protein C6orf203; Chromosome 6 open reading frame 203 |
| CLHC1 protein network | https://string-db.org/network/9606.ENSP00000384869 | Clathrin heavy chain linker domain containing 1 |
| TRIM66 protein network | https://string-db.org/network/9606.ENSP00000384876 | Tripartite motif-containing protein 66; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as [...] |
| ABCB5 protein network | https://string-db.org/network/9606.ENSP00000384881 | ATP-binding cassette sub-family B member 5; Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of th [...] |
| IFI30 protein network | https://string-db.org/network/9606.ENSP00000384886 | Gamma-interferon-inducible lysosomal thiol reductase; Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal d [...] |
| CEACAM19 protein network | https://string-db.org/network/9606.ENSP00000384887 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| AQP12B protein network | https://string-db.org/network/9606.ENSP00000384894 | Aquaporin-12B; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily |
| SAA1 protein network | https://string-db.org/network/9606.ENSP00000384906 | Serum amyloid A-1 protein; Major acute phase protein; Belongs to the SAA family |
| SVEP1 protein network | https://string-db.org/network/9606.ENSP00000384917 | Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process; Sushi domain containing |
| C22orf29 protein network | https://string-db.org/network/9606.ENSP00000384924 | Protein Bop; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signal [...] |
| GPR12 protein network | https://string-db.org/network/9606.ENSP00000384932 | G-protein coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP pr [...] |
| PYCR1 protein network | https://string-db.org/network/9606.ENSP00000384949 | Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Invol [...] |
| SULT6B1 protein network | https://string-db.org/network/9606.ENSP00000384950 | Sulfotransferase 6B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of thyroxine. Involved in the metabolism of thyro [...] |
| MRPS12 protein network | https://string-db.org/network/9606.ENSP00000384952 | Mitochondrial ribosomal protein S12 |
| F11 protein network | https://string-db.org/network/9606.ENSP00000384957 | Coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX |
| C22orf15 protein network | https://string-db.org/network/9606.ENSP00000384965 | Uncharacterized protein C22orf15; Chromosome 22 open reading frame 15 |
| IMMP2L protein network | https://string-db.org/network/9606.ENSP00000384966 | Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into th [...] |
| LRRC72 protein network | https://string-db.org/network/9606.ENSP00000384971 | Leucine-rich repeat-containing protein 72; Leucine rich repeat containing 72 |
| TBC1D10A protein network | https://string-db.org/network/9606.ENSP00000384996 | TBC1 domain family member 10A; Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A |
| P4HA2 protein network | https://string-db.org/network/9606.ENSP00000384999 | Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins |
| KIF2A protein network | https://string-db.org/network/9606.ENSP00000385000 | Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progre [...] |
| THAP4 protein network | https://string-db.org/network/9606.ENSP00000385006 | THAP domain containing 4 |
| CACNA1I protein network | https://string-db.org/network/9606.ENSP00000385019 | Voltage-dependent T-type calcium channel subunit alpha-1I; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of c [...] |
| FANCL protein network | https://string-db.org/network/9606.ENSP00000385021 | E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitina [...] |
| SMCR8 protein network | https://string-db.org/network/9606.ENSP00000385025 | Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9 [...] |
| CHRNA2 protein network | https://string-db.org/network/9606.ENSP00000385026 | Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| SLC22A23 protein network | https://string-db.org/network/9606.ENSP00000385028 | Solute carrier family 22 member 23 |
| C1S protein network | https://string-db.org/network/9606.ENSP00000385035 | Complement C1s subcomponent; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s s [...] |
| TCL1A protein network | https://string-db.org/network/9606.ENSP00000385036 | T-cell leukemia/lymphoma protein 1A; Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondr [...] |
| APOBEC3G protein network | https://string-db.org/network/9606.ENSP00000385057 | DNA dC->dU-editing enzyme APOBEC-3G; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| FAH protein network | https://string-db.org/network/9606.ENSP00000385080 | Fumarylacetoacetase; Fumarylacetoacetate hydrolase |
| KDSR protein network | https://string-db.org/network/9606.ENSP00000385083 | 3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| NLRC4 protein network | https://string-db.org/network/9606.ENSP00000385090 | NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome [...] |
| KCTD17 protein network | https://string-db.org/network/9606.ENSP00000385096 | BTB/POZ domain-containing protein KCTD17; Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING u [...] |
| ALS2CR12 protein network | https://string-db.org/network/9606.ENSP00000385098 | Amyotrophic lateral sclerosis 2 chromosome region 12 |
| ZNF792 protein network | https://string-db.org/network/9606.ENSP00000385099 | Zinc finger protein 792; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PRR16 protein network | https://string-db.org/network/9606.ENSP00000385118 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those [...] |
| NRXN1 protein network | https://string-db.org/network/9606.ENSP00000385142 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have [...] |
| UNC5D protein network | https://string-db.org/network/9606.ENSP00000385143 | Netrin receptor UNC5D; Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cel [...] |
| FAM161A protein network | https://string-db.org/network/9606.ENSP00000385158 | Protein FAM161A; Involved in ciliogenesis |
| ZNF155 protein network | https://string-db.org/network/9606.ENSP00000385163 | Zinc finger protein 155; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PICK1 protein network | https://string-db.org/network/9606.ENSP00000385205 | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the [...] |
| CEP162 protein network | https://string-db.org/network/9606.ENSP00000385215 | Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the dista [...] |
| NCOA1 protein network | https://string-db.org/network/9606.ENSP00000385216 | Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the co [...] |
| CAPN14 protein network | https://string-db.org/network/9606.ENSP00000385247 | Calpain-14; Calcium-regulated non-lysosomal thiol-protease; Calpains |
| ELAVL1 protein network | https://string-db.org/network/9606.ENSP00000385269 | ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNA [...] |
| ELFN2 protein network | https://string-db.org/network/9606.ENSP00000385277 | Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Fibronectin type III domain containing |
| RNF32 protein network | https://string-db.org/network/9606.ENSP00000385285 | RING finger protein 32; May play a role in sperm formation; Ring finger proteins |
| CLDN15 protein network | https://string-db.org/network/9606.ENSP00000385300 | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers [...] |
| SLC25A19 protein network | https://string-db.org/network/9606.ENSP00000385312 | Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria; Solute carriers |
| MAD1L1 protein network | https://string-db.org/network/9606.ENSP00000385334 | Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plat [...] |
| TAPT1 protein network | https://string-db.org/network/9606.ENSP00000385347 | Transmembrane anterior posterior transformation protein 1 homolog; Plays a role in primary cilia formation. May act as a downstream effector of HOXC8 possibly by transducing or transmitting extra [...] |
| CCDC157 protein network | https://string-db.org/network/9606.ENSP00000385357 | Coiled-coil domain containing 157 |
| VPREB1 protein network | https://string-db.org/network/9606.ENSP00000385361 | Immunoglobulin iota chain; Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in [...] |
| PDIA6 protein network | https://string-db.org/network/9606.ENSP00000385385 | Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensor [...] |
| NOLC1 protein network | https://string-db.org/network/9606.ENSP00000385410 | Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and mod [...] |
| GAGE10 protein network | https://string-db.org/network/9606.ENSP00000385415 | G antigen 10; Belongs to the GAGE family |
| SAR1B protein network | https://string-db.org/network/9606.ENSP00000385432 | GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the [...] |
| RSPH10B protein network | https://string-db.org/network/9606.ENSP00000385443 | Radial spoke head 10 homolog B |
| MAGI1 protein network | https://string-db.org/network/9606.ENSP00000385450 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating [...] |
| MDK protein network | https://string-db.org/network/9606.ENSP00000385451 | Midkine; Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activatio [...] |
| CGREF1 protein network | https://string-db.org/network/9606.ENSP00000385452 | Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines; EF-hand domain contai [...] |
| TFDP3 protein network | https://string-db.org/network/9606.ENSP00000385461 | Transcription factor Dp family member 3; Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase; Belongs to the E2F/DP fa [...] |
| C22orf46 protein network | https://string-db.org/network/9606.ENSP00000385467 | Uncharacterized protein C22orf46; Chromosome 22 open reading frame 46 |
| TNFSF18 protein network | https://string-db.org/network/9606.ENSP00000385470 | Tumor necrosis factor ligand superfamily member 18; Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activat [...] |
| CLDN5 protein network | https://string-db.org/network/9606.ENSP00000385477 | Claudin-5; Plays a major role in tight junction-specific obliteration of the intercellular space; Claudins |
| ISPD protein network | https://string-db.org/network/9606.ENSP00000385478 | D-ribitol-5-phosphate cytidylyltransferase; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP- ribitol nucleotide sugar from D-ribitol 5-phosphate. [...] |
| HIST2H3A protein network | https://string-db.org/network/9606.ENSP00000385479 | Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones there [...] |
| SYCE3 protein network | https://string-db.org/network/9606.ENSP00000385480 | Synaptonemal complex central element protein 3; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. R [...] |
| TMEM211 protein network | https://string-db.org/network/9606.ENSP00000385494 | Transmembrane protein 211 |
| GPSM2 protein network | https://string-db.org/network/9606.ENSP00000385510 | G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein- dynactin complex recruitment during met [...] |
| PPARA protein network | https://string-db.org/network/9606.ENSP00000385523 | Peroxisome proliferator-activated receptor alpha; Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3- [...] |
| MFSD2B protein network | https://string-db.org/network/9606.ENSP00000385527 | Major facilitator superfamily domain-containing protein 2B; Cation-dependent lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets. Sphin [...] |
| KIF26B protein network | https://string-db.org/network/9606.ENSP00000385545 | Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by inter [...] |
| ICA1 protein network | https://string-db.org/network/9606.ENSP00000385570 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing |
| HIPK2 protein network | https://string-db.org/network/9606.ENSP00000385571 | Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a co [...] |
| KIAA1841 protein network | https://string-db.org/network/9606.ENSP00000385579 | Uncharacterized protein KIAA1841; KIAA1841 |
| HOXD12 protein network | https://string-db.org/network/9606.ENSP00000385586 | Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| IGSF23 protein network | https://string-db.org/network/9606.ENSP00000385592 | Immunoglobulin superfamily member 23; Immunoglobulin like domain containing |
| MEX3C protein network | https://string-db.org/network/9606.ENSP00000385610 | RNA-binding E3 ubiquitin-protein ligase MEX3C; E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulate [...] |
| SUN2 protein network | https://string-db.org/network/9606.ENSP00000385616 | SUN domain-containing protein 2; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nu [...] |
| PDE7A protein network | https://string-db.org/network/9606.ENSP00000385632 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle [...] |
| OBSL1 protein network | https://string-db.org/network/9606.ENSP00000385636 | Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it co [...] |
| IL6 protein network | https://string-db.org/network/9606.ENSP00000385675 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- s [...] |
| HERC3 protein network | https://string-db.org/network/9606.ENSP00000385684 | Probable E3 ubiquitin-protein ligase HERC3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...] |
| GRAMD4 protein network | https://string-db.org/network/9606.ENSP00000385689 | GRAM domain-containing protein 4; Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53; GRAM domain containing |
| SEC14L6 protein network | https://string-db.org/network/9606.ENSP00000385695 | Putative SEC14-like protein 6; SEC14 like lipid binding 6 |
| PSG2 protein network | https://string-db.org/network/9606.ENSP00000385706 | Pregnancy specific beta-1-glycoprotein 2 |
| ARHGAP35 protein network | https://string-db.org/network/9606.ENSP00000385720 | Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP), binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhi [...] |
| GGT2 protein network | https://string-db.org/network/9606.ENSP00000385721 | Inactive glutathione hydrolase 2; Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically a [...] |
| INTS1 protein network | https://string-db.org/network/9606.ENSP00000385722 | Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| MAST4 protein network | https://string-db.org/network/9606.ENSP00000385727 | Microtubule associated serine/threonine kinase family member 4; PDZ domain containing |
| GAL3ST1 protein network | https://string-db.org/network/9606.ENSP00000385735 | Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catal [...] |
| CEACAM21 protein network | https://string-db.org/network/9606.ENSP00000385739 | Carcinoembryonic antigen related cell adhesion molecule family; Belongs to the immunoglobulin superfamily. CEA family |
| APOBEC3H protein network | https://string-db.org/network/9606.ENSP00000385741 | DNA dC->dU-editing enzyme APOBEC-3H; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent [...] |
| SMS protein network | https://string-db.org/network/9606.ENSP00000385746 | Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) |
| PRKAR1B protein network | https://string-db.org/network/9606.ENSP00000385749 | cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells |
| MARK2 protein network | https://string-db.org/network/9606.ENSP00000385751 | Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, M [...] |
| BLVRA protein network | https://string-db.org/network/9606.ENSP00000385757 | Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo [...] |
| PTGR1 protein network | https://string-db.org/network/9606.ENSP00000385763 | Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similar [...] |
| DGKB protein network | https://string-db.org/network/9606.ENSP00000385780 | Diacylglycerol kinase beta; Exhibits high phosphorylation activity for long-chain diacylglycerols |
| POP1 protein network | https://string-db.org/network/9606.ENSP00000385787 | Ribonucleases P/MRP protein subunit POP1; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP |
| SDSL protein network | https://string-db.org/network/9606.ENSP00000385790 | Serine dehydratase-like; Has low serine dehydratase and threonine dehydratase activity |
| PHF14 protein network | https://string-db.org/network/9606.ENSP00000385795 | PHD finger protein 14 |
| KIF3A protein network | https://string-db.org/network/9606.ENSP00000385808 | Kinesin-like protein KIF3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. [...] |
| RPAIN protein network | https://string-db.org/network/9606.ENSP00000385814 | RPA-interacting protein; Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA comple [...] |
| FOXO3 protein network | https://string-db.org/network/9606.ENSP00000385824 | Forkhead box protein O3; Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DN [...] |
| TST protein network | https://string-db.org/network/9606.ENSP00000385828 | Thiosulfate sulfurtransferase; Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur i [...] |
| TF protein network | https://string-db.org/network/9606.ENSP00000385834 | Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transp [...] |
| FAM26D protein network | https://string-db.org/network/9606.ENSP00000385836 | Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel |
| SETD5 protein network | https://string-db.org/network/9606.ENSP00000385852 | SET domain-containing protein 5; Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of hi [...] |
| DUSP28 protein network | https://string-db.org/network/9606.ENSP00000385885 | Dual specificity phosphatase 28; Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate (in vitro); Atypical dual specificity phosphatases |
| ANKMY1 protein network | https://string-db.org/network/9606.ENSP00000385887 | Ankyrin repeat and MYND domain containing 1 |
| PLEKHB2 protein network | https://string-db.org/network/9606.ENSP00000385892 | Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes; Pleckstrin homology domain containing |
| SDK1 protein network | https://string-db.org/network/9606.ENSP00000385899 | Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promote [...] |
| NAA60 protein network | https://string-db.org/network/9606.ENSP00000385903 | N-alpha-acetyltransferase 60; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini fac [...] |
| DNASE1 protein network | https://string-db.org/network/9606.ENSP00000385905 | Deoxyribonuclease-1; Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity) |
| NUCB1 protein network | https://string-db.org/network/9606.ENSP00000385923 | Nucleobindin-1; Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity); Belongs to the nucleobindin family |
| RMDN1 protein network | https://string-db.org/network/9606.ENSP00000385927 | Regulator of microtubule dynamics 1 |
| DCDC1 protein network | https://string-db.org/network/9606.ENSP00000385936 | Doublecortin domain-containing protein 5; Doublecortin domain containing 1 |
| ZNF12 protein network | https://string-db.org/network/9606.ENSP00000385939 | Zinc finger protein 12; Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity; Belongs to the krueppel C2H2-ty [...] |
| KBTBD12 protein network | https://string-db.org/network/9606.ENSP00000385957 | Kelch repeat and BTB domain containing 12 |
| RPS14 protein network | https://string-db.org/network/9606.ENSP00000385958 | Ribosomal protein S14 |
| KCNS3 protein network | https://string-db.org/network/9606.ENSP00000385968 | Potassium voltage-gated channel subfamily S member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulat [...] |
| THADA protein network | https://string-db.org/network/9606.ENSP00000385995 | Thyroid adenoma-associated protein; THADA, armadillo repeat containing; Belongs to the THADA family |
| MS4A15 protein network | https://string-db.org/network/9606.ENSP00000386022 | Membrane-spanning 4-domains subfamily A member 15; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| BUD31 protein network | https://string-db.org/network/9606.ENSP00000386023 | Protein BUD31 homolog; Spliceosomal Bact complex |
| GABRR2 protein network | https://string-db.org/network/9606.ENSP00000386029 | Gamma-aminobutyric acid receptor subunit rho-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...] |
| RPA3OS protein network | https://string-db.org/network/9606.ENSP00000386039 | UBAP1-MVB12-associated (UMA)-domain containing protein 1; RPA3 opposite strand |
| MYH6 protein network | https://string-db.org/network/9606.ENSP00000386041 | Myosin-6; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family |
| LTBP1 protein network | https://string-db.org/network/9606.ENSP00000386043 | Latent-transforming growth factor beta-binding protein 1; May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical role [...] |
| MBD5 protein network | https://string-db.org/network/9606.ENSP00000386049 | Methyl-CpG-binding domain protein 5; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro); Methyl-CpG binding domain containing |
| ADRA2C protein network | https://string-db.org/network/9606.ENSP00000386069 | Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins; Adrenoceptors |
| CPE protein network | https://string-db.org/network/9606.ENSP00000386104 | Carboxypeptidase E; Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin; Belongs to the peptidase M14 family |
| TEX33 protein network | https://string-db.org/network/9606.ENSP00000386118 | Testis-expressed protein 33; Testis expressed 33 |
| ARMC5 protein network | https://string-db.org/network/9606.ENSP00000386125 | Armadillo repeat-containing protein 5; Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a ro [...] |
| UMODL1 protein network | https://string-db.org/network/9606.ENSP00000386126 | Uromodulin like 1 |
| POM121L12 protein network | https://string-db.org/network/9606.ENSP00000386133 | POM121-like protein 12; POM121 transmembrane nucleoporin like 12; Belongs to the POM121 family |
| NGDN protein network | https://string-db.org/network/9606.ENSP00000386134 | Neuroguidin; Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs |
| DAPK1 protein network | https://string-db.org/network/9606.ENSP00000386135 | Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regu [...] |
| OR2A14 protein network | https://string-db.org/network/9606.ENSP00000386137 | Olfactory receptor 2A14; Odorant receptor; Olfactory receptors, family 2 |
| OR1C1 protein network | https://string-db.org/network/9606.ENSP00000386138 | Olfactory receptor 1C1; Odorant receptor; Olfactory receptors, family 1 |
| XKR9 protein network | https://string-db.org/network/9606.ENSP00000386141 | XK-related protein 9; XK related family |
| HEPN1 protein network | https://string-db.org/network/9606.ENSP00000386143 | Putative cancer susceptibility gene HEPN1 protein; Hepatocellular carcinoma, down-regulated 1 |
| C6orf226 protein network | https://string-db.org/network/9606.ENSP00000386146 | Uncharacterized protein C6orf226; Chromosome 6 open reading frame 226 |
| OR6B1 protein network | https://string-db.org/network/9606.ENSP00000386151 | Olfactory receptor 6B1; Odorant receptor; Olfactory receptors, family 6 |
| WIBG protein network | https://string-db.org/network/9606.ENSP00000386156 | Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positiona [...] |
| LCNL1 protein network | https://string-db.org/network/9606.ENSP00000386162 | Lipocalin-like 1 protein; Lipocalin like 1; Belongs to the calycin superfamily. Lipocalin family |
| TMEM14E protein network | https://string-db.org/network/9606.ENSP00000386163 | Transmembrane protein 14E |
| CEBPD protein network | https://string-db.org/network/9606.ENSP00000386165 | CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many e [...] |
| PRR21 protein network | https://string-db.org/network/9606.ENSP00000386166 | Proline rich 21 |
| OR2A25 protein network | https://string-db.org/network/9606.ENSP00000386167 | Olfactory receptor 2A25; Odorant receptor; Olfactory receptors, family 2 |
| TBX20 protein network | https://string-db.org/network/9606.ENSP00000386170 | T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenoty [...] |
| OR2A12 protein network | https://string-db.org/network/9606.ENSP00000386174 | Olfactory receptor 2A12; Odorant receptor; Olfactory receptors, family 2 |
| OR2A1 protein network | https://string-db.org/network/9606.ENSP00000386175 | Olfactory receptor 2A1/2A42; Odorant receptor; Olfactory receptors, family 2 |
| OR3A2 protein network | https://string-db.org/network/9606.ENSP00000386180 | Olfactory receptor 3A2; Odorant receptor; Olfactory receptors, family 3 |
| TTC30B protein network | https://string-db.org/network/9606.ENSP00000386181 | Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are tra [...] |
| ZBED8 protein network | https://string-db.org/network/9606.ENSP00000386184 | Protein ZBED8; Zinc finger BED-type containing 8 |
| TIGD1 protein network | https://string-db.org/network/9606.ENSP00000386186 | Tigger transposable element-derived protein 1; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| IFITM1 protein network | https://string-db.org/network/9606.ENSP00000386187 | Interferon-induced transmembrane protein 1; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral f [...] |
| C2orf16 protein network | https://string-db.org/network/9606.ENSP00000386190 | Uncharacterized protein C2orf16; Chromosome 2 open reading frame 16 |
| ARIH2OS protein network | https://string-db.org/network/9606.ENSP00000386193 | Uncharacterized protein ARIH2OS; Ariadne RBR E3 ubiquitin protein ligase 2 opposite strand |
| OR4E2 protein network | https://string-db.org/network/9606.ENSP00000386195 | Olfactory receptor 4E2; Odorant receptor; Olfactory receptors, family 4 |
| FOXP2 protein network | https://string-db.org/network/9606.ENSP00000386200 | Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal an [...] |
| TAS2R41 protein network | https://string-db.org/network/9606.ENSP00000386201 | Taste receptor type 2 member 41; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| HMSD protein network | https://string-db.org/network/9606.ENSP00000386207 | Serpin-like protein HMSD; Putative serine protease inhibitor; Minor histocompatibility antigens |
| OR2A5 protein network | https://string-db.org/network/9606.ENSP00000386208 | Olfactory receptor 2A5; Odorant receptor; Olfactory receptors, family 2 |
| OR2A2 protein network | https://string-db.org/network/9606.ENSP00000386209 | Olfactory receptor 2A2; Odorant receptor; Olfactory receptors, family 2 |
| TAS2R40 protein network | https://string-db.org/network/9606.ENSP00000386210 | Taste receptor type 2 member 40; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calci [...] |
| PSMB11 protein network | https://string-db.org/network/9606.ENSP00000386212 | Proteasome subunit beta type-11; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the le [...] |
| MYO3B protein network | https://string-db.org/network/9606.ENSP00000386213 | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear ha [...] |
| C3orf36 protein network | https://string-db.org/network/9606.ENSP00000386219 | Uncharacterized protein C3orf36; Chromosome 3 open reading frame 36 |
| OR2F2 protein network | https://string-db.org/network/9606.ENSP00000386222 | Olfactory receptor 2F2; Odorant receptor; Olfactory receptors, family 2 |
| RBM34 protein network | https://string-db.org/network/9606.ENSP00000386226 | RNA-binding protein 34; RNA binding motif containing; Belongs to the RRM RBM34 family |
| MCC protein network | https://string-db.org/network/9606.ENSP00000386227 | Colorectal mutant cancer protein; Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer ce [...] |
| RGS14 protein network | https://string-db.org/network/9606.ENSP00000386229 | Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby d [...] |
| C19orf73 protein network | https://string-db.org/network/9606.ENSP00000386230 | Putative uncharacterized protein C19orf73; Chromosome 19 open reading frame 73 |
| TONSL protein network | https://string-db.org/network/9606.ENSP00000386239 | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is re [...] |
| TMEM237 protein network | https://string-db.org/network/9606.ENSP00000386264 | Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family |
| SLC38A11 protein network | https://string-db.org/network/9606.ENSP00000386272 | Putative sodium-coupled neutral amino acid transporter 11; Putative sodium-dependent amino acid/proton antiporter; Solute carriers |
| CNPPD1 protein network | https://string-db.org/network/9606.ENSP00000386277 | Protein CNPPD1; Cyclin Pas1/PHO80 domain containing 1 |
| APOL6 protein network | https://string-db.org/network/9606.ENSP00000386280 | Apolipoprotein L6; May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles; Apolipoproteins |
| ALAD protein network | https://string-db.org/network/9606.ENSP00000386284 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes t [...] |
| GULP1 protein network | https://string-db.org/network/9606.ENSP00000386289 | PTB domain-containing engulfment adapter protein 1; May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholestero [...] |
| TMEM194B protein network | https://string-db.org/network/9606.ENSP00000386292 | Nuclear envelope integral membrane protein 2; Transmembrane protein 194B; Belongs to the NEMP family |
| C2orf76 protein network | https://string-db.org/network/9606.ENSP00000386302 | UPF0538 protein C2orf76; Chromosome 2 open reading frame 76; Belongs to the UPF0538 family |
| SCN9A protein network | https://string-db.org/network/9606.ENSP00000386306 | Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| MYO7A protein network | https://string-db.org/network/9606.ENSP00000386331 | Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous [...] |
| SFTPB protein network | https://string-db.org/network/9606.ENSP00000386346 | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air s [...] |
| SAPCD2 protein network | https://string-db.org/network/9606.ENSP00000386348 | Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions (By s [...] |
| LRRTM4 protein network | https://string-db.org/network/9606.ENSP00000386357 | Leucine-rich repeat transmembrane neuronal protein 4; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to exc [...] |
| KRTAP19-3 protein network | https://string-db.org/network/9606.ENSP00000386376 | Keratin-associated protein 19-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| MGAT5 protein network | https://string-db.org/network/9606.ENSP00000386377 | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oli [...] |
| CD207 protein network | https://string-db.org/network/9606.ENSP00000386378 | C-type lectin domain family 4 member K; Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superim [...] |
| IL1R1 protein network | https://string-db.org/network/9606.ENSP00000386380 | Interleukin-1 receptor type 1; Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex whi [...] |
| PXMP4 protein network | https://string-db.org/network/9606.ENSP00000386385 | Peroxisomal membrane protein 4 |
| KLHL30 protein network | https://string-db.org/network/9606.ENSP00000386389 | Kelch-like protein 30; Kelch like family member 30; BTB domain containing |
| NIF3L1 protein network | https://string-db.org/network/9606.ENSP00000386394 | NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation |
| ANKRD30BL protein network | https://string-db.org/network/9606.ENSP00000386398 | Putative ankyrin repeat domain-containing protein 30B-like; Ankyrin repeat domain containing |
| RAD21L1 protein network | https://string-db.org/network/9606.ENSP00000386414 | Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required duri [...] |
| ZNF638 protein network | https://string-db.org/network/9606.ENSP00000386433 | Zinc finger protein 638; Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SR [...] |
| SYNC protein network | https://string-db.org/network/9606.ENSP00000386439 | Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facili [...] |
| TGOLN2 protein network | https://string-db.org/network/9606.ENSP00000386443 | Trans-Golgi network integral membrane protein 2; May be involved in regulating membrane traffic to and from trans-Golgi network |
| SAG protein network | https://string-db.org/network/9606.ENSP00000386444 | S-arrestin; Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated- phosphorylated rhodopsin, thereby apparently preventing the transducin-media [...] |
| C7orf34 protein network | https://string-db.org/network/9606.ENSP00000386450 | LLLL and CFNLAS motif-containing protein 1; Chromosome 7 open reading frame 34 |
| C17orf104 protein network | https://string-db.org/network/9606.ENSP00000386452 | Meiosis-specific coiled-coil domain-containing protein MEIOC; Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing [...] |
| CYSRT1 protein network | https://string-db.org/network/9606.ENSP00000386453 | Cysteine rich tail 1 |
| AAK1 protein network | https://string-db.org/network/9606.ENSP00000386456 | AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP [...] |
| PRPF40A protein network | https://string-db.org/network/9606.ENSP00000386458 | Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Play [...] |
| APOPT1 protein network | https://string-db.org/network/9606.ENSP00000386485 | Apoptogenic protein 1, mitochondrial; Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c fro [...] |
| ZC3H8 protein network | https://string-db.org/network/9606.ENSP00000386488 | Zinc finger CCCH domain-containing protein 8; Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the n [...] |
| HOXD3 protein network | https://string-db.org/network/9606.ENSP00000386498 | Homeobox protein Hox-D3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| PRR35 protein network | https://string-db.org/network/9606.ENSP00000386499 | Proline-rich protein 35; Proline rich 35 |
| ANKRD61 protein network | https://string-db.org/network/9606.ENSP00000386502 | Ankyrin repeat domain-containing protein 61; Ankyrin repeat domain containing |
| RAD54L2 protein network | https://string-db.org/network/9606.ENSP00000386520 | Helicase ARIP4; DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity); Belongs [...] |
| SMPD4 protein network | https://string-db.org/network/9606.ENSP00000386531 | Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide |
| ASB18 protein network | https://string-db.org/network/9606.ENSP00000386532 | Ankyrin repeat and SOCS box protein 18; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| TBC1D10B protein network | https://string-db.org/network/9606.ENSP00000386538 | TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A |
| PSMD14 protein network | https://string-db.org/network/9606.ENSP00000386541 | 26S proteasome non-ATPase regulatory subunit 14; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a [...] |
| PREPL protein network | https://string-db.org/network/9606.ENSP00000386543 | Prolyl endopeptidase-like; Probable serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue. May play a role in the regul [...] |
| C19orf24 protein network | https://string-db.org/network/9606.ENSP00000386557 | Uncharacterized membrane protein C19orf24; Chromosome 19 open reading frame 24 |
| CD8A protein network | https://string-db.org/network/9606.ENSP00000386559 | T-cell surface glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external an [...] |
| MORN2 protein network | https://string-db.org/network/9606.ENSP00000386563 | MORN repeat-containing protein 2; Might have a role in spermatogenesis |
| RGPD3 protein network | https://string-db.org/network/9606.ENSP00000386588 | RanBP2-like and GRIP domain-containing protein 3; Tetratricopeptide repeat domain containing |
| DPAGT1 protein network | https://string-db.org/network/9606.ENSP00000386597 | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides |
| C7orf31 protein network | https://string-db.org/network/9606.ENSP00000386604 | Uncharacterized protein C7orf31; Chromosome 7 open reading frame 31 |
| VSTM5 protein network | https://string-db.org/network/9606.ENSP00000386607 | V-set and transmembrane domain-containing protein 5; Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by [...] |
| WDR81 protein network | https://string-db.org/network/9606.ENSP00000386609 | WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying [...] |
| ZC3H12D protein network | https://string-db.org/network/9606.ENSP00000386616 | Probable ribonuclease ZC3H12D; May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association [...] |
| SSB protein network | https://string-db.org/network/9606.ENSP00000386636 | Lupus La protein; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of [...] |
| DFNB59 protein network | https://string-db.org/network/9606.ENSP00000386647 | Pejvakin; Essential in the activity of auditory pathway neurons |
| MCFD2 protein network | https://string-db.org/network/9606.ENSP00000386651 | Multiple coagulation factor deficiency protein 2; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coag [...] |
| PCDH20 protein network | https://string-db.org/network/9606.ENSP00000386653 | Protocadherin 20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| RPL36A-HNRNPH2 protein network | https://string-db.org/network/9606.ENSP00000386655 | RPL36A-HNRNPH2 readthrough; Belongs to the eukaryotic ribosomal protein eL42 family |
| FAM183B protein network | https://string-db.org/network/9606.ENSP00000386657 | Protein FAM183BP; Family with sequence similarity 183, member B; Belongs to the FAM183 family |
| KDM3A protein network | https://string-db.org/network/9606.ENSP00000386660 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and di [...] |
| FHL2 protein network | https://string-db.org/network/9606.ENSP00000386665 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor [...] |
| MYADML2 protein network | https://string-db.org/network/9606.ENSP00000386702 | Myeloid-associated differentiation marker-like protein 2; Myeloid associated differentiation marker like 2 |
| ATG9A protein network | https://string-db.org/network/9606.ENSP00000386710 | Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore [...] |
| JAKMIP1 protein network | https://string-db.org/network/9606.ENSP00000386711 | Janus kinase and microtubule-interacting protein 1; Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signali [...] |
| RPL31 protein network | https://string-db.org/network/9606.ENSP00000386717 | Ribosomal protein L31 |
| FCHSD2 protein network | https://string-db.org/network/9606.ENSP00000386722 | FCH and double SH3 domains 2; F-BAR domain containing |
| KCMF1 protein network | https://string-db.org/network/9606.ENSP00000386738 | E3 ubiquitin-protein ligase KCMF1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination; Belongs to the KCMF1 family |
| CHN1 protein network | https://string-db.org/network/9606.ENSP00000386741 | N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance |
| SETD2 protein network | https://string-db.org/network/9606.ENSP00000386759 | Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represen [...] |
| ZC3H6 protein network | https://string-db.org/network/9606.ENSP00000386764 | Zinc finger CCCH-type containing 6 |
| SLC39A10 protein network | https://string-db.org/network/9606.ENSP00000386766 | Zinc transporter ZIP10; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family |
| DNAH10 protein network | https://string-db.org/network/9606.ENSP00000386770 | Dynein heavy chain 10, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| GPATCH11 protein network | https://string-db.org/network/9606.ENSP00000386772 | G-patch domain containing 11 |
| ENSG00000184761 protein network | https://string-db.org/network/9606.ENSP00000386773 | Uncharacterized protein |
| KIAA0922 protein network | https://string-db.org/network/9606.ENSP00000386787 | Transmembrane protein 131-like; Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyt [...] |
| UBE2E3 protein network | https://string-db.org/network/9606.ENSP00000386788 | Ubiquitin-conjugating enzyme E2 E3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-, as well as 'Lys-63' [...] |
| C21orf140 protein network | https://string-db.org/network/9606.ENSP00000386791 | Uncharacterized protein C21orf140; Chromosome 21 open reading frame 140 |
| SCN7A protein network | https://string-db.org/network/9606.ENSP00000386796 | Sodium channel protein type 7 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage diff [...] |
| C2orf82 protein network | https://string-db.org/network/9606.ENSP00000386804 | Uncharacterized protein C2orf82; Chromosome 2 open reading frame 82 |
| C4orf48 protein network | https://string-db.org/network/9606.ENSP00000386807 | Neuropeptide-like protein C4orf48; Chromosome 4 open reading frame 48 |
| RGPD4 protein network | https://string-db.org/network/9606.ENSP00000386810 | RanBP2-like and GRIP domain-containing protein 4; Tetratricopeptide repeat domain containing |
| AFF3 protein network | https://string-db.org/network/9606.ENSP00000386834 | AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA; Belongs to the AF4 family |
| XIRP2 protein network | https://string-db.org/network/9606.ENSP00000386840 | Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization; Belongs to the Xin family |
| ZNF385B protein network | https://string-db.org/network/9606.ENSP00000386845 | Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis |
| ACTG2 protein network | https://string-db.org/network/9606.ENSP00000386857 | Actin, gamma-enteric smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| SH3BP4 protein network | https://string-db.org/network/9606.ENSP00000386862 | SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may ac [...] |
| TET3 protein network | https://string-db.org/network/9606.ENSP00000386869 | Methylcytosine dioxygenase TET3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigene [...] |
| DCDC2B protein network | https://string-db.org/network/9606.ENSP00000386870 | Doublecortin domain containing 2B |
| DYSF protein network | https://string-db.org/network/9606.ENSP00000386881 | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocy [...] |
| CXCR4 protein network | https://string-db.org/network/9606.ENSP00000386884 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts a [...] |
| RBM4 protein network | https://string-db.org/network/9606.ENSP00000386894 | RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site [...] |
| FAM124B protein network | https://string-db.org/network/9606.ENSP00000386895 | Protein FAM124B; Family with sequence similarity 124 member B; Belongs to the FAM124 family |
| ITGA6 protein network | https://string-db.org/network/9606.ENSP00000386896 | Integrin alpha-6; Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in [...] |
| PTGES3L protein network | https://string-db.org/network/9606.ENSP00000386902 | Putative protein PTGES3L; Prostaglandin E synthase 3 like |
| MEGF11 protein network | https://string-db.org/network/9606.ENSP00000386908 | Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a m [...] |
| ARHGAP25 protein network | https://string-db.org/network/9606.ENSP00000386911 | Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; Pleckstrin homology domain containing |
| KDELR3 protein network | https://string-db.org/network/9606.ENSP00000386918 | ER lumen protein-retaining receptor 3; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required f [...] |
| TBC1D14 protein network | https://string-db.org/network/9606.ENSP00000386921 | TBC1 domain family member 14; Negative regulator of starvation-induced autophagosome formation |
| LYG1 protein network | https://string-db.org/network/9606.ENSP00000386923 | Lysozyme g-like protein 1; Lysozymes, g-type |
| STK16 protein network | https://string-db.org/network/9606.ENSP00000386928 | Serine/threonine-protein kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphor [...] |
| UAP1L1 protein network | https://string-db.org/network/9606.ENSP00000386935 | UDP-N-acetylhexosamine pyrophosphorylase-like protein 1; UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 |
| ST6GAL2 protein network | https://string-db.org/network/9606.ENSP00000386942 | Beta-galactoside alpha-2,6-sialyltransferase 2; Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase act [...] |
| CAPS2 protein network | https://string-db.org/network/9606.ENSP00000386959 | Calcyphosin-2; EF-hand domain containing |
| CATSPERG protein network | https://string-db.org/network/9606.ENSP00000386962 | Cation channel sperm-associated protein subunit gamma; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility w [...] |
| CALCRL protein network | https://string-db.org/network/9606.ENSP00000386972 | Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Recep [...] |
| CC2D2B protein network | https://string-db.org/network/9606.ENSP00000386988 | Protein CC2D2B; Coiled-coil and C2 domain containing 2B |
| IPO11 protein network | https://string-db.org/network/9606.ENSP00000386992 | Importin-11; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the [...] |
| CWC22 protein network | https://string-db.org/network/9606.ENSP00000387006 | Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicin [...] |
| NCAPG2 protein network | https://string-db.org/network/9606.ENSP00000387007 | Condensin-2 complex subunit G2; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid ax [...] |
| R3HDM1 protein network | https://string-db.org/network/9606.ENSP00000387010 | R3H domain containing 1 |
| ARHGEF33 protein network | https://string-db.org/network/9606.ENSP00000387020 | Rho guanine nucleotide exchange factor 33; May act as a guanine-nucleotide releasing factor; Rho guanine nucleotide exchange factors |
| C5orf52 protein network | https://string-db.org/network/9606.ENSP00000387027 | Uncharacterized protein C5orf52; Chromosome 5 open reading frame 52 |
| PPM1M protein network | https://string-db.org/network/9606.ENSP00000387046 | Protein phosphatase, Mg2+/Mn2+ dependent 1M; Belongs to the PP2C family |
| PLD3 protein network | https://string-db.org/network/9606.ENSP00000387050 | Phospholipase D3; May be involved in APP processing; Belongs to the phospholipase D family |
| FAM168B protein network | https://string-db.org/network/9606.ENSP00000387051 | Myelin-associated neurite-outgrowth inhibitor; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CD [...] |
| TRABD2A protein network | https://string-db.org/network/9606.ENSP00000387075 | Metalloprotease TIKI1; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Followin [...] |
| LYPD6B protein network | https://string-db.org/network/9606.ENSP00000387077 | Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent ma [...] |
| WDSUB1 protein network | https://string-db.org/network/9606.ENSP00000387078 | WD repeat, sterile alpha motif and U-box domain containing 1 |
| TISP43 protein network | https://string-db.org/network/9606.ENSP00000387081 | Uncharacterized LOC150527 |
| ZNF365 protein network | https://string-db.org/network/9606.ENSP00000387091 | Protein ZNF365; Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth. Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. [...] |
| TPRN protein network | https://string-db.org/network/9606.ENSP00000387100 | Taperin; Deafness associated genes |
| ENSG00000273155 protein network | https://string-db.org/network/9606.ENSP00000387111 | annotation not available |
| CLEC16A protein network | https://string-db.org/network/9606.ENSP00000387122 | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. Th [...] |
| ALDH7A1 protein network | https://string-db.org/network/9606.ENSP00000387123 | Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl don [...] |
| C2orf78 protein network | https://string-db.org/network/9606.ENSP00000387124 | Uncharacterized protein C2orf78; Chromosome 2 open reading frame 78 |
| NCKAP5 protein network | https://string-db.org/network/9606.ENSP00000387128 | NCK associated protein 5 |
| NPPC protein network | https://string-db.org/network/9606.ENSP00000387159 | C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be va [...] |
| CPVL protein network | https://string-db.org/network/9606.ENSP00000387164 | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for [...] |
| GIGYF2 protein network | https://string-db.org/network/9606.ENSP00000387170 | GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that [...] |
| POTEJ protein network | https://string-db.org/network/9606.ENSP00000387176 | POTE ankyrin domain family member J; In the N-terminal section; belongs to the POTE family |
| ATHL1 protein network | https://string-db.org/network/9606.ENSP00000387185 | Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins |
| SERF2 protein network | https://string-db.org/network/9606.ENSP00000387187 | Positive regulator of amyloid protein aggregation and proteotoxicity . Induces conformational changes in amyloid proteins, such as HTT, driving them into compact formations preceding the formatio [...] |
| CEP19 protein network | https://string-db.org/network/9606.ENSP00000387209 | Centrosomal protein of 19 kDa; Required for ciliation. Recruits the RABL2B GTPase to the ciliary base to initiate ciliation. After specifically capturing the activated GTP-bound RABL2B, the CEP19 [...] |
| IL18R1 protein network | https://string-db.org/network/9606.ENSP00000387211 | Interleukin-18 receptor 1; Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable). Contributes to IL18-induced cytoki [...] |
| NFU1 protein network | https://string-db.org/network/9606.ENSP00000387219 | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe-2S] clusters and deliver them to target proteins; Belongs to the NifU family |
| MAP3K2 protein network | https://string-db.org/network/9606.ENSP00000387246 | Mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K [...] |
| PCDH13 protein network | https://string-db.org/network/9606.ENSP00000387250 | Protocadherin-20; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins |
| PSTPIP2 protein network | https://string-db.org/network/9606.ENSP00000387261 | Proline-serine-threonine phosphatase-interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity); F-BAR domain containing |
| IMMT protein network | https://string-db.org/network/9606.ENSP00000387262 | MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner mem [...] |
| SPIRE1 protein network | https://string-db.org/network/9606.ENSP00000387266 | Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibe [...] |
| MPP4 protein network | https://string-db.org/network/9606.ENSP00000387278 | MAGUK p55 subfamily member 4; May play a role in retinal photoreceptors development; Membrane associated guanylate kinases |
| AGFG1 protein network | https://string-db.org/network/9606.ENSP00000387282 | Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis (By similarity). May play a role in RNA trafficking or localization. In case o [...] |
| RAB1A protein network | https://string-db.org/network/9606.ENSP00000387286 | Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| TMEM150A protein network | https://string-db.org/network/9606.ENSP00000387292 | Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K comp [...] |
| ERICH2 protein network | https://string-db.org/network/9606.ENSP00000387298 | Glutamate-rich protein 2; Glutamate rich 2 |
| TDRD9 protein network | https://string-db.org/network/9606.ENSP00000387303 | ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase required during spermatogenesis. Required to repress transposable elements and prevent their mobilization, which is essential for the ge [...] |
| RAB6C protein network | https://string-db.org/network/9606.ENSP00000387307 | Ras-related protein Rab-6C; May be involved in the regulation of centrosome duplication and cell cycle progression; RAB, member RAS oncogene GTPases |
| NOTUM protein network | https://string-db.org/network/9606.ENSP00000387310 | Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Ser [...] |
| LRRC29 protein network | https://string-db.org/network/9606.ENSP00000387318 | Leucine-rich repeat-containing protein 29; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation |
| NLRX1 protein network | https://string-db.org/network/9606.ENSP00000387334 | NLR family member X1; Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-M [...] |
| ACAN protein network | https://string-db.org/network/9606.ENSP00000387356 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds av [...] |
| SBNO1 protein network | https://string-db.org/network/9606.ENSP00000387361 | Strawberry notch homolog 1 |
| UBE4A protein network | https://string-db.org/network/9606.ENSP00000387362 | Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the [...] |
| PWP1 protein network | https://string-db.org/network/9606.ENSP00000387365 | Periodic tryptophan protein 1 homolog; May play an important role in cell growth and/or transcription; Belongs to the WD repeat PWP1 family |
| NECAB1 protein network | https://string-db.org/network/9606.ENSP00000387380 | N-terminal EF-hand calcium binding protein 1; EF-hand domain containing |
| CYHR1 protein network | https://string-db.org/network/9606.ENSP00000387426 | Cysteine and histidine rich 1; Belongs to the CYHR1 family |
| ARTN protein network | https://string-db.org/network/9606.ENSP00000387435 | Artemin; Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture [...] |
| ZBTB10 protein network | https://string-db.org/network/9606.ENSP00000387462 | Zinc finger and BTB domain-containing protein 10; May be involved in transcriptional regulation; BTB domain containing |
| FAM96B protein network | https://string-db.org/network/9606.ENSP00000387471 | Mitotic spindle-associated MMXD complex subunit MIP18; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur [...] |
| FUT2 protein network | https://string-db.org/network/9606.ENSP00000387498 | Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a [...] |
| OR7E24 protein network | https://string-db.org/network/9606.ENSP00000387523 | Olfactory receptor 7E24; Odorant receptor; Olfactory receptors, family 7 |
| IRGQ protein network | https://string-db.org/network/9606.ENSP00000387535 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family |
| PDK3 protein network | https://string-db.org/network/9606.ENSP00000387536 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose [...] |
| SLC18A1 protein network | https://string-db.org/network/9606.ENSP00000387549 | Chromaffin granule amine transporter; Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells; Be [...] |
| TANC2 protein network | https://string-db.org/network/9606.ENSP00000387593 | Protein TANC2; Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2; Belongs to the TANC family |
| SMCO2 protein network | https://string-db.org/network/9606.ENSP00000387617 | Single-pass membrane protein with coiled-coil domains 2 |
| CAND2 protein network | https://string-db.org/network/9606.ENSP00000387641 | Cullin-associated NEDD8-dissociated protein 2; Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-bo [...] |
| PCYOX1 protein network | https://string-db.org/network/9606.ENSP00000387654 | Prenylcysteine oxidase 1; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine |
| GCG protein network | https://string-db.org/network/9606.ENSP00000387662 | Glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life; Belongs to th [...] |
| ENSG00000167377 protein network | https://string-db.org/network/9606.ENSP00000387673 | Zinc finger protein 23; May be involved in transcriptional regulation. May have a role in embryonic development; Belongs to the krueppel C2H2-type zinc-finger protein family |
| UGT2B11 protein network | https://string-db.org/network/9606.ENSP00000387683 | UDP-glucuronosyltransferase 2B11; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds; Belongs to the UDP-glycosyl [...] |
| SLC12A5 protein network | https://string-db.org/network/9606.ENSP00000387694 | Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chlo [...] |
| CREB1 protein network | https://string-db.org/network/9606.ENSP00000387699 | Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence prese [...] |
| TARS protein network | https://string-db.org/network/9606.ENSP00000387710 | Threonine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II |
| AMOTL1 protein network | https://string-db.org/network/9606.ENSP00000387739 | Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus; Belongs to [...] |
| HIC2 protein network | https://string-db.org/network/9606.ENSP00000387757 | Hypermethylated in cancer 2 protein; Transcriptional repressor; BTB domain containing |
| ENSG00000264813 protein network | https://string-db.org/network/9606.ENSP00000387760 | Angiotensin-converting enzyme; Uncharacterized protein |
| SOS1 protein network | https://string-db.org/network/9606.ENSP00000387784 | Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic compon [...] |
| BRDT protein network | https://string-db.org/network/9606.ENSP00000387822 | Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role [...] |
| KIF4B protein network | https://string-db.org/network/9606.ENSP00000387875 | Chromosome-associated kinesin KIF4B; Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step f [...] |
| TC2N protein network | https://string-db.org/network/9606.ENSP00000387882 | Synaptotagmin like tandem C2 proteins |
| UGT2A1 protein network | https://string-db.org/network/9606.ENSP00000387888 | UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water so [...] |
| ANKUB1 protein network | https://string-db.org/network/9606.ENSP00000387907 | Protein ANKUB1; Ankyrin repeat and ubiquitin domain containing 1 |
| PARN protein network | https://string-db.org/network/9606.ENSP00000387911 | Poly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tai [...] |
| IFFO2 protein network | https://string-db.org/network/9606.ENSP00000387941 | Intermediate filament family orphan 2; Belongs to the intermediate filament family |
| WDR73 protein network | https://string-db.org/network/9606.ENSP00000387982 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; WD repeat domain containing |
| OAS1 protein network | https://string-db.org/network/9606.ENSP00000388001 | 2'-5'-oligoadenylate synthase 1; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in ot [...] |
| KRBOX1 protein network | https://string-db.org/network/9606.ENSP00000388094 | KRAB box domain containing 1 |
| UBA52 protein network | https://string-db.org/network/9606.ENSP00000388107 | Ubiquitin-60S ribosomal protein L40; Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isope [...] |
| MPPED1 protein network | https://string-db.org/network/9606.ENSP00000388137 | Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro) |
| ARPC4 protein network | https://string-db.org/network/9606.ENSP00000388169 | Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nuc [...] |
| RNF148 protein network | https://string-db.org/network/9606.ENSP00000388207 | Ring finger protein 148 |
| ENSG00000249624 protein network | https://string-db.org/network/9606.ENSP00000388223 | annotation not available |
| KIF26A protein network | https://string-db.org/network/9606.ENSP00000388241 | Kinesin-like protein KIF26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, po [...] |
| AGBL3 protein network | https://string-db.org/network/9606.ENSP00000388275 | Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generat [...] |
| TSTD1 protein network | https://string-db.org/network/9606.ENSP00000388293 | Thiosulfate:glutathione sulfurtransferase; Thiosulfate:glutathione sulfurtransferase (TST) required to produce glutathione persulfide (GSS(-)), a central intermediate in hydrogen sulfide metaboli [...] |
| TRIM49C protein network | https://string-db.org/network/9606.ENSP00000388299 | Tripartite motif containing 49C; Ring finger proteins |
| ZNF845 protein network | https://string-db.org/network/9606.ENSP00000388311 | Zinc finger protein 845; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CTU2 protein network | https://string-db.org/network/9606.ENSP00000388320 | Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with [...] |
| LAMB2 protein network | https://string-db.org/network/9606.ENSP00000388325 | Laminin subunit beta-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| SEC61G protein network | https://string-db.org/network/9606.ENSP00000388337 | Protein transport protein Sec61 subunit gamma; Necessary for protein translocation in the endoplasmic reticulum; Belongs to the SecE/SEC61-gamma family |
| ZFP36L1 protein network | https://string-db.org/network/9606.ENSP00000388402 | mRNA decay activator protein ZFP36L1; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail remov [...] |
| TMEM251 protein network | https://string-db.org/network/9606.ENSP00000388431 | Transmembrane protein 251; Belongs to the TMEM251 family |
| ZNF583 protein network | https://string-db.org/network/9606.ENSP00000388502 | Zinc finger protein 583; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RARG protein network | https://string-db.org/network/9606.ENSP00000388510 | Retinoic acid receptor gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic [...] |
| RNF24 protein network | https://string-db.org/network/9606.ENSP00000388550 | RING finger protein 24; May play a role in TRPCs intracellular trafficking; Ring finger proteins |
| RBM14-RBM4 protein network | https://string-db.org/network/9606.ENSP00000388552 | RNA-binding protein 14; RBM14-RBM4 readthrough |
| CASP4 protein network | https://string-db.org/network/9606.ENSP00000388566 | Caspase-4; Inflammatory caspase. Essential effector of NLRP3 inflammasome- dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation, c [...] |
| EOMES protein network | https://string-db.org/network/9606.ENSP00000388620 | Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesod [...] |
| PLCD4 protein network | https://string-db.org/network/9606.ENSP00000388631 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and in [...] |
| RBM17 protein network | https://string-db.org/network/9606.ENSP00000388638 | Splicing factor 45; Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alterna [...] |
| CHEK1 protein network | https://string-db.org/network/9606.ENSP00000388648 | Serine/threonine-protein kinase Chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA d [...] |
| SLC25A12 protein network | https://string-db.org/network/9606.ENSP00000388658 | Calcium-binding mitochondrial carrier protein Aralar1; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May [...] |
| TMEM247 protein network | https://string-db.org/network/9606.ENSP00000388684 | Transmembrane protein 247 |
| LANCL1 protein network | https://string-db.org/network/9606.ENSP00000388713 | LanC-like protein 1; May play a role in EPS8 signaling. Binds glutathione |
| KBTBD13 protein network | https://string-db.org/network/9606.ENSP00000388723 | Kelch repeat and BTB domain-containing protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex; BTB domain containing |
| SSFA2 protein network | https://string-db.org/network/9606.ENSP00000388731 | Sperm specific antigen 2 |
| EIF4B protein network | https://string-db.org/network/9606.ENSP00000388806 | Eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in prese [...] |
| NSG1 protein network | https://string-db.org/network/9606.ENSP00000388823 | Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosome [...] |
| MLN protein network | https://string-db.org/network/9606.ENSP00000388825 | Promotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Endogenous liga [...] |
| PNMA5 protein network | https://string-db.org/network/9606.ENSP00000388850 | Paraneoplastic antigen-like protein 5; Paraneoplastic Ma antigens; Belongs to the PNMA family |
| ZNF419 protein network | https://string-db.org/network/9606.ENSP00000388864 | Zinc finger protein 419; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| KIF25 protein network | https://string-db.org/network/9606.ENSP00000388878 | Kinesin-like protein KIF25; Minus-end microtubule-dependent motor protein (By similarity). Acts as a negative regulator of centrosome separation required to prevent premature centrosome separatio [...] |
| SPATA3 protein network | https://string-db.org/network/9606.ENSP00000388895 | Spermatogenesis-associated protein 3; Spermatogenesis associated 3 |
| C17orf62 protein network | https://string-db.org/network/9606.ENSP00000388909 | Uncharacterized protein C17orf62; Chromosome 17 open reading frame 62 |
| NFATC4 protein network | https://string-db.org/network/9606.ENSP00000388910 | Nuclear factor of activated T-cells, cytoplasmic 4; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally rep [...] |
| RWDD4 protein network | https://string-db.org/network/9606.ENSP00000388920 | RWD domain containing 4 |
| TCF12 protein network | https://string-db.org/network/9606.ENSP00000388940 | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'); Basic helix-loop-helix [...] |
| SCRN1 protein network | https://string-db.org/network/9606.ENSP00000388942 | Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity) |
| AP1M1 protein network | https://string-db.org/network/9606.ENSP00000388996 | AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate t [...] |
| CARNS1 protein network | https://string-db.org/network/9606.ENSP00000389009 | Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine |
| C5orf42 protein network | https://string-db.org/network/9606.ENSP00000389014 | Protein JBTS17; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and [...] |
| SBK2 protein network | https://string-db.org/network/9606.ENSP00000389015 | Serine/threonine-protein kinase SBK2; SH3 domain binding kinase family member 2 |
| CRISP3 protein network | https://string-db.org/network/9606.ENSP00000389026 | Cysteine rich secretory protein family; Belongs to the CRISP family |
| MMADHC protein network | https://string-db.org/network/9606.ENSP00000389060 | Methylmalonic aciduria and homocystinuria type D protein, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenos [...] |
| OR10G8 protein network | https://string-db.org/network/9606.ENSP00000389072 | Olfactory receptor 10G8; Odorant receptor; Olfactory receptors, family 10 |
| RPL23A protein network | https://string-db.org/network/9606.ENSP00000389103 | 60S ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA; Belongs to the universal ribosomal protein uL23 family |
| C1orf233 protein network | https://string-db.org/network/9606.ENSP00000389111 | Fibronectin type III domain-containing protein 10; Chromosome 1 open reading frame 233 |
| DCC protein network | https://string-db.org/network/9606.ENSP00000389140 | Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with U [...] |
| NDUFA11 protein network | https://string-db.org/network/9606.ENSP00000389160 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...] |
| PPP1R12A protein network | https://string-db.org/network/9606.ENSP00000389168 | Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Cap [...] |
| GLYCTK protein network | https://string-db.org/network/9606.ENSP00000389175 | Glycerate kinase; Belongs to the glycerate kinase type-2 family |
| C1GALT1 protein network | https://string-db.org/network/9606.ENSP00000389176 | Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for ma [...] |
| RPP30 protein network | https://string-db.org/network/9606.ENSP00000389182 | Ribonuclease P protein subunit p30; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends |
| NBPF4 protein network | https://string-db.org/network/9606.ENSP00000389237 | Neuroblastoma breakpoint family member 4; NBPF member 4 |
| DHRS9 protein network | https://string-db.org/network/9606.ENSP00000389241 | Dehydrogenase/reductase SDR family member 9; 3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstaned [...] |
| ENSG00000273303 protein network | https://string-db.org/network/9606.ENSP00000389243 | Zinc finger protein with KRAB and SCAN domains 7 |
| NPNT protein network | https://string-db.org/network/9606.ENSP00000389252 | Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May als [...] |
| HCAR1 protein network | https://string-db.org/network/9606.ENSP00000389255 | Hydroxycarboxylic acid receptor 1; Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway; Hydroxy-carboxylic acid receptors |
| ENSG00000233024 protein network | https://string-db.org/network/9606.ENSP00000389275 | LOC339047 protein; Nuclear pore complex-interacting protein family member A5; Protein LOC101930008 |
| TMBIM6 protein network | https://string-db.org/network/9606.ENSP00000389277 | Bax inhibitor 1; Suppressor of apoptosis. Modulates unfolded protein response signaling. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and a [...] |
| AKR1B15 protein network | https://string-db.org/network/9606.ENSP00000389289 | Aldo-keto reductase family 1 member B15; Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydro [...] |
| ACE2 protein network | https://string-db.org/network/9606.ENSP00000389326 | Angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able t [...] |
| NFATC1 protein network | https://string-db.org/network/9606.ENSP00000389377 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also [...] |
| YY2 protein network | https://string-db.org/network/9606.ENSP00000389381 | Transcription factor YY2; Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in develop [...] |
| GPAT2 protein network | https://string-db.org/network/9606.ENSP00000389395 | Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required f [...] |
| TMCO3 protein network | https://string-db.org/network/9606.ENSP00000389399 | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family |
| TBXAS1 protein network | https://string-db.org/network/9606.ENSP00000389414 | Thromboxane-A synthase; Cytochrome P450 family 5 |
| CEP44 protein network | https://string-db.org/network/9606.ENSP00000389427 | Centrosomal protein 44 |
| USP17L12 protein network | https://string-db.org/network/9606.ENSP00000389443 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 12; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| UBAP2L protein network | https://string-db.org/network/9606.ENSP00000389445 | Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs) |
| DIRC3 protein network | https://string-db.org/network/9606.ENSP00000389455 | Disrupted in renal carcinoma 3 |
| TGM7 protein network | https://string-db.org/network/9606.ENSP00000389466 | Protein-glutamine gamma-glutamyltransferase Z; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins; Belongs to the transglutaminase superfamily. Transglutaminase [...] |
| CT47A4 protein network | https://string-db.org/network/9606.ENSP00000389513 | Cancer/testis antigen family 47, member A4 |
| C2CD4D protein network | https://string-db.org/network/9606.ENSP00000389554 | C2 calcium-dependent domain-containing protein 4D; C2 calcium dependent domain containing 4D |
| SEMA5B protein network | https://string-db.org/network/9606.ENSP00000389588 | Semaphorin-5B; May act as positive axonal guidance cues; Semaphorins |
| TLR6 protein network | https://string-db.org/network/9606.ENSP00000389600 | Toll-like receptor 6; Participates in the innate immune response to Gram- positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In res [...] |
| OR2M3 protein network | https://string-db.org/network/9606.ENSP00000389625 | Olfactory receptor 2M3; Odorant receptor; Olfactory receptors, family 2 |
| DPY19L4 protein network | https://string-db.org/network/9606.ENSP00000389630 | Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins |
| ARPC1B protein network | https://string-db.org/network/9606.ENSP00000389631 | Actin-related protein 2/3 complex subunit 1B; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promo [...] |
| ATP5J protein network | https://string-db.org/network/9606.ENSP00000389649 | ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membr [...] |
| RNF212 protein network | https://string-db.org/network/9606.ENSP00000389709 | Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific reco [...] |
| CTNNA3 protein network | https://string-db.org/network/9606.ENSP00000389714 | Catenin alpha-3; May be involved in formation of stretch-resistant cell- cell adhesion complexes; Alpha catenins |
| KSR2 protein network | https://string-db.org/network/9606.ENSP00000389715 | Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low effi [...] |
| CYB561A3 protein network | https://string-db.org/network/9606.ENSP00000389745 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron don [...] |
| GATS protein network | https://string-db.org/network/9606.ENSP00000389760 | Putative protein GATS; GATS, stromal antigen 3 opposite strand; Belongs to the GATS family |
| PLEKHF1 protein network | https://string-db.org/network/9606.ENSP00000389787 | Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosoma [...] |
| DSN1 protein network | https://string-db.org/network/9606.ENSP00000389810 | Kinetochore-associated protein DSN1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis |
| ACAD10 protein network | https://string-db.org/network/9606.ENSP00000389813 | Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2- methyl-C15-CoA |
| ADIPOQ protein network | https://string-db.org/network/9606.ENSP00000389814 | Adiponectin; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK p [...] |
| ZNF852 protein network | https://string-db.org/network/9606.ENSP00000389841 | Zinc finger protein 852; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SLC38A4 protein network | https://string-db.org/network/9606.ENSP00000389843 | Sodium-coupled neutral amino acid transporter 4; Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a pre [...] |
| DLX3 protein network | https://string-db.org/network/9606.ENSP00000389870 | Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less home [...] |
| DCUN1D4 protein network | https://string-db.org/network/9606.ENSP00000389900 | DCN1-like protein 4; Defective in cullin neddylation 1 domain containing 4 |
| LETMD1 protein network | https://string-db.org/network/9606.ENSP00000389903 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53; Solute carriers |
| RCBTB2 protein network | https://string-db.org/network/9606.ENSP00000389910 | RCC1 and BTB domain containing protein 2 |
| PLEKHM1 protein network | https://string-db.org/network/9606.ENSP00000389913 | Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosom [...] |
| NT5C3B protein network | https://string-db.org/network/9606.ENSP00000389948 | 7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7 [...] |
| TMEM67 protein network | https://string-db.org/network/9606.ENSP00000389998 | Meckelin; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By simil [...] |
| CTU1 protein network | https://string-db.org/network/9606.ENSP00000390011 | Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts [...] |
| HLA-DOB protein network | https://string-db.org/network/9606.ENSP00000390020 | HLA class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifie [...] |
| CT47A5 protein network | https://string-db.org/network/9606.ENSP00000390070 | Cancer/testis antigen family 47, member A5 |
| ZSCAN31 protein network | https://string-db.org/network/9606.ENSP00000390076 | Zinc finger and SCAN domain-containing protein 31; May function as a transcription factor. May be involved in the development of multiple embryonic organs; Belongs to the krueppel C2H2-type zinc- [...] |
| SHISA6 protein network | https://string-db.org/network/9606.ENSP00000390084 | Protein shisa-6 homolog; Shisa family member 6 |
| PLSCR5 protein network | https://string-db.org/network/9606.ENSP00000390111 | Phospholipid scramblase family member 5; Belongs to the phospholipid scramblase family |
| HERC1 protein network | https://string-db.org/network/9606.ENSP00000390158 | Probable E3 ubiquitin-protein ligase HERC1; Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and [...] |
| ZNF527 protein network | https://string-db.org/network/9606.ENSP00000390179 | Zinc finger protein 527; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HEPACAM2 protein network | https://string-db.org/network/9606.ENSP00000390204 | HEPACAM family member 2; Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosome [...] |
| ZBBX protein network | https://string-db.org/network/9606.ENSP00000390232 | Zinc finger B-box domain containing |
| IDH1 protein network | https://string-db.org/network/9606.ENSP00000390265 | Isocitrate dehydrogenase 1, cytosolic |
| ENSG00000239789 protein network | https://string-db.org/network/9606.ENSP00000390331 | HCG1984214, isoform CRA_a; Mitochondrial ribosomal protein S17 |
| TMEM213 protein network | https://string-db.org/network/9606.ENSP00000390407 | Transmembrane protein 213 |
| GPR141 protein network | https://string-db.org/network/9606.ENSP00000390410 | Probable G-protein coupled receptor 141; Orphan receptor; G protein-coupled receptors, Class A orphans |
| CATSPER4 protein network | https://string-db.org/network/9606.ENSP00000390423 | Cation channel sperm-associated protein 4; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as spe [...] |
| HLA-DQB2 protein network | https://string-db.org/network/9606.ENSP00000390431 | Major histocompatibility complex, class II, DQ beta 2; Belongs to the MHC class II family |
| GLI2 protein network | https://string-db.org/network/9606.ENSP00000390436 | Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor (By similarity) [...] |
| CXXC1 protein network | https://string-db.org/network/9606.ENSP00000390475 | CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG; PHD finger proteins |
| SLC16A5 protein network | https://string-db.org/network/9606.ENSP00000390564 | Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...] |
| DDN protein network | https://string-db.org/network/9606.ENSP00000390590 | Dendrin; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retentio [...] |
| SCN10A protein network | https://string-db.org/network/9606.ENSP00000390600 | Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conforma [...] |
| BTNL2 protein network | https://string-db.org/network/9606.ENSP00000390613 | Butyrophilin-like protein 2; Negative regulator of T-cell proliferation; Belongs to the immunoglobulin superfamily. BTN/MOG family |
| TDRD12 protein network | https://string-db.org/network/9606.ENSP00000390621 | Putative ATP-dependent RNA helicase TDRD12; Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essentia [...] |
| HNRNPLL protein network | https://string-db.org/network/9606.ENSP00000390625 | Heterogeneous nuclear ribonucleoprotein L-like; RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for al [...] |
| RIMBP3C protein network | https://string-db.org/network/9606.ENSP00000390630 | RIMS binding protein 3C; Belongs to the RIMBP family |
| SLC14A1 protein network | https://string-db.org/network/9606.ENSP00000390637 | Urea transporter 1; Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through w [...] |
| IRAK4 protein network | https://string-db.org/network/9606.ENSP00000390651 | Interleukin-1 receptor-associated kinase 4; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like recept [...] |
| CLEC2L protein network | https://string-db.org/network/9606.ENSP00000390661 | C-type lectin domain family 2 member L |
| SLC25A17 protein network | https://string-db.org/network/9606.ENSP00000390722 | Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine m [...] |
| BORCS8-MEF2B protein network | https://string-db.org/network/9606.ENSP00000390762 | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in [...] |
| MEIOB protein network | https://string-db.org/network/9606.ENSP00000390778 | Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and cro [...] |
| SCFD1 protein network | https://string-db.org/network/9606.ENSP00000390783 | Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endopla [...] |
| B3GALT4 protein network | https://string-db.org/network/9606.ENSP00000390784 | Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis; Beta 3-glycosyltransferases |
| ABHD5 protein network | https://string-db.org/network/9606.ENSP00000390849 | 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; Lysophosphatidic acid acyltransferase which functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol t [...] |
| LRRC23 protein network | https://string-db.org/network/9606.ENSP00000390932 | Leucine-rich repeat-containing protein 23; Leucine rich repeat containing 23 |
| ATCAY protein network | https://string-db.org/network/9606.ENSP00000390941 | Caytaxin; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GL [...] |
| UNC80 protein network | https://string-db.org/network/9606.ENSP00000391088 | Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and e [...] |
| SLFN14 protein network | https://string-db.org/network/9606.ENSP00000391101 | Protein SLFN14; Protein SLFN14: Shows no ribosome-associated and endoribonuclease activities; Belongs to the Schlafen family |
| RDH13 protein network | https://string-db.org/network/9606.ENSP00000391121 | Retinol dehydrogenase 13; Does not exhibit retinol dehydrogenase (RDH) activity in vitro; Short chain dehydrogenase/reductase superfamily |
| ASB10 protein network | https://string-db.org/network/9606.ENSP00000391137 | Ankyrin repeat and SOCS box protein 10; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| DENND4A protein network | https://string-db.org/network/9606.ENSP00000391167 | C-myc promoter-binding protein; Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into th [...] |
| ZNF692 protein network | https://string-db.org/network/9606.ENSP00000391200 | Zinc finger protein 692; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CYB561D2 protein network | https://string-db.org/network/9606.ENSP00000391209 | Cytochrome b561 family member D2 |
| PSMC2 protein network | https://string-db.org/network/9606.ENSP00000391211 | 26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| MGAT5B protein network | https://string-db.org/network/9606.ENSP00000391227 | Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N- ac [...] |
| SEPT9 protein network | https://string-db.org/network/9606.ENSP00000391249 | Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria [...] |
| SAMD7 protein network | https://string-db.org/network/9606.ENSP00000391299 | Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes; Sterile alpha motif dom [...] |
| SEPT5 protein network | https://string-db.org/network/9606.ENSP00000391311 | Septin-5; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity); Belongs to the TRAFAC class TrmE [...] |
| MT1G protein network | https://string-db.org/network/9606.ENSP00000391397 | Metallothionein-1G; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| C4orf51 protein network | https://string-db.org/network/9606.ENSP00000391404 | Uncharacterized protein C4orf51; Chromosome 4 open reading frame 51 |
| CDHR4 protein network | https://string-db.org/network/9606.ENSP00000391409 | Cadherin-related family member 4; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may th [...] |
| INO80C protein network | https://string-db.org/network/9606.ENSP00000391457 | Chromosome 18 open reading frame 37, isoform CRA_a; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably [...] |
| TKT protein network | https://string-db.org/network/9606.ENSP00000391481 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the t [...] |
| PNMA6A protein network | https://string-db.org/network/9606.ENSP00000391488 | Paraneoplastic antigen-like protein 6A; Paraneoplastic Ma antigens; Belongs to the PNMA family |
| AGR2 protein network | https://string-db.org/network/9606.ENSP00000391490 | Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene [...] |
| KCNK16 protein network | https://string-db.org/network/9606.ENSP00000391498 | Potassium channel subfamily K member 16; Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents; Potassium two pore domain channel [...] |
| CCDC173 protein network | https://string-db.org/network/9606.ENSP00000391504 | Coiled-coil domain containing 173 |
| DENND6B protein network | https://string-db.org/network/9606.ENSP00000391524 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35; DENN/MADD domain containing |
| SMIM19 protein network | https://string-db.org/network/9606.ENSP00000391549 | Small integral membrane protein 19 |
| PARVG protein network | https://string-db.org/network/9606.ENSP00000391583 | Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family |
| PTPN6 protein network | https://string-db.org/network/9606.ENSP00000391592 | Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with ot [...] |
| ERV3-1 protein network | https://string-db.org/network/9606.ENSP00000391594 | Endogenous retrovirus group 3 member 1 Env polyprotein; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have [...] |
| AMDHD2 protein network | https://string-db.org/network/9606.ENSP00000391596 | N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N- glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. A [...] |
| PEX5 protein network | https://string-db.org/network/9606.ENSP00000391601 | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import |
| ZNF780B protein network | https://string-db.org/network/9606.ENSP00000391641 | Zinc finger protein 780B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MFRP protein network | https://string-db.org/network/9606.ENSP00000391664 | Membrane frizzled-related protein; May play a role in eye development |
| MTMR11 protein network | https://string-db.org/network/9606.ENSP00000391668 | Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a [...] |
| BCAR1 protein network | https://string-db.org/network/9606.ENSP00000391669 | Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of [...] |
| JAK3 protein network | https://string-db.org/network/9606.ENSP00000391676 | Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate a [...] |
| CCDC103 protein network | https://string-db.org/network/9606.ENSP00000391692 | Coiled-coil domain containing 103; Dynein-attachment factor required for cilia motility; Belongs to the CCDC103/PR46b family |
| PUM1 protein network | https://string-db.org/network/9606.ENSP00000391723 | Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Respo [...] |
| LACC1 protein network | https://string-db.org/network/9606.ENSP00000391747 | Laccase domain-containing protein 1; Central regulator of the metabolic function and bioenergetic state of macrophages. In macrophages, promotes flux through de novo lipogenesis to concomitantly [...] |
| PILRB protein network | https://string-db.org/network/9606.ENSP00000391748 | Paired immunoglobin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB [...] |
| CCDC36 protein network | https://string-db.org/network/9606.ENSP00000391788 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114 [...] |
| APLN protein network | https://string-db.org/network/9606.ENSP00000391800 | Apelin; Endogenous ligands |
| ENSG00000250264 protein network | https://string-db.org/network/9606.ENSP00000391806 | Uncharacterized protein; Belongs to the MHC class II family |
| IGF2 protein network | https://string-db.org/network/9606.ENSP00000391826 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. [...] |
| FAM187A protein network | https://string-db.org/network/9606.ENSP00000391869 | annotation not available |
| NECAP2 protein network | https://string-db.org/network/9606.ENSP00000391942 | Adaptin ear-binding coat-associated protein 2; Involved in endocytosis |
| ANKRD36 protein network | https://string-db.org/network/9606.ENSP00000391950 | Ankyrin repeat domain-containing protein 36A; Ankyrin repeat domain containing |
| ZNF844 protein network | https://string-db.org/network/9606.ENSP00000392024 | Zinc finger protein 844; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CYLD protein network | https://string-db.org/network/9606.ENSP00000392025 | Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulati [...] |
| CHD7 protein network | https://string-db.org/network/9606.ENSP00000392028 | Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production; DNA helicases |
| ATP2B1 protein network | https://string-db.org/network/9606.ENSP00000392043 | Plasma membrane calcium-transporting ATPase 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell; ATPases Ca2+ transporting |
| REPS1 protein network | https://string-db.org/network/9606.ENSP00000392065 | RalBP1-associated Eps domain-containing protein 1; May coordinate the cellular actions of activated EGF receptors and Ral-GTPases; EF-hand domain containing |
| DIP2A protein network | https://string-db.org/network/9606.ENSP00000392066 | Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system |
| EFTUD2 protein network | https://string-db.org/network/9606.ENSP00000392094 | 116 kDa U5 small nuclear ribonucleoprotein component; Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translati [...] |
| C1orf106 protein network | https://string-db.org/network/9606.ENSP00000392105 | Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine [...] |
| PPP6C protein network | https://string-db.org/network/9606.ENSP00000392147 | Protein phosphatase 6 catalytic subunit |
| KRTAP9-3 protein network | https://string-db.org/network/9606.ENSP00000392189 | Keratin-associated protein 9-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| KLLN protein network | https://string-db.org/network/9606.ENSP00000392204 | Killin; DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled t [...] |
| AGAP10 protein network | https://string-db.org/network/9606.ENSP00000392206 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10 |
| TTLL8 protein network | https://string-db.org/network/9606.ENSP00000392252 | Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non- tubulin proteins, generating side chains of glycine on the gamma- carboxyl groups of specific glutamate residues of [...] |
| PPIL6 protein network | https://string-db.org/network/9606.ENSP00000392257 | Peptidyl-prolyl cis-trans isomerase-like 6; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Cyclophilin pept [...] |
| STRAP protein network | https://string-db.org/network/9606.ENSP00000392270 | Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Th [...] |
| CT47A7 protein network | https://string-db.org/network/9606.ENSP00000392283 | Cancer/testis antigen family 47, member A7 |
| IFRD2 protein network | https://string-db.org/network/9606.ENSP00000392316 | Interferon related developmental regulator 2; Armadillo-like helical domain containing |
| CSRP2BP protein network | https://string-db.org/network/9606.ENSP00000392318 | Cysteine-rich protein 2-binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to [...] |
| BCAP31 protein network | https://string-db.org/network/9606.ENSP00000392330 | B-cell receptor-associated protein 31; Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER [...] |
| ZNF487 protein network | https://string-db.org/network/9606.ENSP00000392335 | Putative zinc finger protein 487; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PSMG4 protein network | https://string-db.org/network/9606.ENSP00000392353 | Proteasome assembly chaperone 4 |
| C14orf105 protein network | https://string-db.org/network/9606.ENSP00000392368 | Uncharacterized protein CCDC198; Chromosome 14 open reading frame 105 |
| ZSCAN30 protein network | https://string-db.org/network/9606.ENSP00000392371 | Zinc finger and SCAN domain-containing protein 30; May be involved in transcriptional regulation; SCAN domain containing |
| CHFR protein network | https://string-db.org/network/9606.ENSP00000392395 | E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in earl [...] |
| GPX5 protein network | https://string-db.org/network/9606.ENSP00000392398 | Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glut [...] |
| PRR20D protein network | https://string-db.org/network/9606.ENSP00000392407 | Proline rich 20D |
| ZNF587B protein network | https://string-db.org/network/9606.ENSP00000392410 | Zinc finger protein 587B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SLC13A2 protein network | https://string-db.org/network/9606.ENSP00000392411 | Solute carrier family 13 member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate; Solute carriers |
| RELN protein network | https://string-db.org/network/9606.ENSP00000392423 | Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affe [...] |
| FAM219A protein network | https://string-db.org/network/9606.ENSP00000392452 | Protein FAM219A; Family with sequence similarity 219 member A |
| LDB1 protein network | https://string-db.org/network/9606.ENSP00000392466 | LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by de [...] |
| TRAPPC2 protein network | https://string-db.org/network/9606.ENSP00000392495 | Trafficking protein particle complex subunit 2; Prevents transcriptional repression and induction of cell death by ENO1 (By similarity). May play a role in vesicular transport from endoplasmic re [...] |
| NLGN1 protein network | https://string-db.org/network/9606.ENSP00000392500 | Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and pro [...] |
| PRRT3 protein network | https://string-db.org/network/9606.ENSP00000392511 | Proline rich transmembrane protein 3 |
| AGAP4 protein network | https://string-db.org/network/9606.ENSP00000392513 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4; Putative GTPase-activating protein; Ankyrin repeat domain containing |
| TTLL3 protein network | https://string-db.org/network/9606.ENSP00000392549 | Tubulin monoglycylase TTLL3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-termi [...] |
| PPAPDC1B protein network | https://string-db.org/network/9606.ENSP00000392553 | Phospholipid phosphatase 5; Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppre [...] |
| ENSG00000233050 protein network | https://string-db.org/network/9606.ENSP00000392568 | annotation not available |
| SMARCD2 protein network | https://string-db.org/network/9606.ENSP00000392617 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alter [...] |
| ARHGAP28 protein network | https://string-db.org/network/9606.ENSP00000392660 | Rho GTPase-activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state |
| AKIRIN1 protein network | https://string-db.org/network/9606.ENSP00000392678 | Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading t [...] |
| AMER3 protein network | https://string-db.org/network/9606.ENSP00000392700 | APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell [...] |
| NDUFS1 protein network | https://string-db.org/network/9606.ENSP00000392709 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal [...] |
| POTEI protein network | https://string-db.org/network/9606.ENSP00000392718 | POTE ankyrin domain family member I; In the N-terminal section; belongs to the POTE family |
| POM121L2 protein network | https://string-db.org/network/9606.ENSP00000392726 | POM121-like protein 2; POM121 transmembrane nucleoporin like 2; Belongs to the POM121 family |
| DCT protein network | https://string-db.org/network/9606.ENSP00000392762 | L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels; Belongs to the ty [...] |
| MS4A6A protein network | https://string-db.org/network/9606.ENSP00000392770 | Membrane-spanning 4-domains subfamily A member 6A; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family |
| PIK3R5 protein network | https://string-db.org/network/9606.ENSP00000392812 | Phosphoinositide 3-kinase regulatory subunit 5; Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-ga [...] |
| GPSM1 protein network | https://string-db.org/network/9606.ENSP00000392828 | G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha sub [...] |
| TCP11X2 protein network | https://string-db.org/network/9606.ENSP00000392879 | T-complex 11 family, X-linked 2; Belongs to the TCP11 family |
| HSBP1 protein network | https://string-db.org/network/9606.ENSP00000392896 | Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stres [...] |
| PLEKHG2 protein network | https://string-db.org/network/9606.ENSP00000392906 | Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC [...] |
| RFPL4A protein network | https://string-db.org/network/9606.ENSP00000392936 | Ret finger protein like 4A; Ring finger proteins |
| HTATIP2 protein network | https://string-db.org/network/9606.ENSP00000392985 | Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear tra [...] |
| SLC4A10 protein network | https://string-db.org/network/9606.ENSP00000393066 | Sodium-driven chloride bicarbonate exchanger; Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By simi [...] |
| GABRA1 protein network | https://string-db.org/network/9606.ENSP00000393097 | Gamma-aminobutyric acid receptor subunit alpha-1; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine r [...] |
| MAPKBP1 protein network | https://string-db.org/network/9606.ENSP00000393099 | Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and ant [...] |
| LHFPL3 protein network | https://string-db.org/network/9606.ENSP00000393128 | LHFPL tetraspan subfamily member 3 |
| CDC7 protein network | https://string-db.org/network/9606.ENSP00000393139 | Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3 |
| FBXO15 protein network | https://string-db.org/network/9606.ENSP00000393154 | F-box only protein 15; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| TMEM151B protein network | https://string-db.org/network/9606.ENSP00000393161 | Transmembrane protein 151B; Belongs to the TMEM151 family |
| ZNF630 protein network | https://string-db.org/network/9606.ENSP00000393163 | Zinc finger protein 630; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| VPRBP protein network | https://string-db.org/network/9606.ENSP00000393183 | DDB1- and CUL4-associated factor 1; Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles i [...] |
| HES4 protein network | https://string-db.org/network/9606.ENSP00000393198 | Hes family bHLH transcription factor 4; Basic helix-loop-helix proteins |
| CFAP221 protein network | https://string-db.org/network/9606.ENSP00000393222 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis; Cilia and flagella associated |
| RPS18 protein network | https://string-db.org/network/9606.ENSP00000393241 | 40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA; S ribosomal proteins |
| ZNF7 protein network | https://string-db.org/network/9606.ENSP00000393260 | Zinc finger protein 7; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| NANOS1 protein network | https://string-db.org/network/9606.ENSP00000393275 | Nanos homolog 1; May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of inte [...] |
| FGFR1 protein network | https://string-db.org/network/9606.ENSP00000393312 | Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic developmen [...] |
| EPS15L1 protein network | https://string-db.org/network/9606.ENSP00000393313 | Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of i [...] |
| CT47A1 protein network | https://string-db.org/network/9606.ENSP00000393315 | Cancer/testis antigen family 47, member A1 |
| TMX1 protein network | https://string-db.org/network/9606.ENSP00000393316 | Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide [...] |
| EIF4E3 protein network | https://string-db.org/network/9606.ENSP00000393324 | Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhib [...] |
| TBXA2R protein network | https://string-db.org/network/9606.ENSP00000393333 | Thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylino [...] |
| KIF5C protein network | https://string-db.org/network/9606.ENSP00000393379 | Kinesin heavy chain isoform 5C; Mediates dendritic trafficking of mRNAs (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport; B [...] |
| MYO1A protein network | https://string-db.org/network/9606.ENSP00000393392 | Unconventional myosin-Ia; Involved in directing the movement of organelles along actin filaments; Myosins, class I |
| CASP14 protein network | https://string-db.org/network/9606.ENSP00000393417 | Caspase-14; Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum. Seems to play a role in keratinocyte differentiation and is requi [...] |
| SMYD1 protein network | https://string-db.org/network/9606.ENSP00000393453 | Histone-lysine N-methyltransferase SMYD1; Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for [...] |
| CD163L1 protein network | https://string-db.org/network/9606.ENSP00000393474 | Scavenger receptor cysteine-rich type 1 protein M160; Scavenger receptor cysteine rich domain containing |
| ABLIM2 protein network | https://string-db.org/network/9606.ENSP00000393511 | Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity; LIM domain containing |
| IFT27 protein network | https://string-db.org/network/9606.ENSP00000393541 | Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interactio [...] |
| SLC4A4 protein network | https://string-db.org/network/9606.ENSP00000393557 | Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux a [...] |
| PACS2 protein network | https://string-db.org/network/9606.ENSP00000393559 | Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria wi [...] |
| HLA-DPA1 protein network | https://string-db.org/network/9606.ENSP00000393566 | HLA class II histocompatibility antigen, DP alpha 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell sur [...] |
| CEP131 protein network | https://string-db.org/network/9606.ENSP00000393583 | Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating c [...] |
| BIRC6 protein network | https://string-db.org/network/9606.ENSP00000393596 | Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin [...] |
| ADM5 protein network | https://string-db.org/network/9606.ENSP00000393631 | Putative adrenomedullin-5-like protein; Probable non-functional remnant of adrenomedullin-5 |
| FAM126B protein network | https://string-db.org/network/9606.ENSP00000393667 | Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane; Belongs to the FAM126 family |
| FAM73A protein network | https://string-db.org/network/9606.ENSP00000393675 | Mitoguardin 1; Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regu [...] |
| CLEC17A protein network | https://string-db.org/network/9606.ENSP00000393719 | C-type lectin domain family 17, member A; Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alph [...] |
| SESN1 protein network | https://string-db.org/network/9606.ENSP00000393762 | Sestrin-1; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 a [...] |
| FCHO2 protein network | https://string-db.org/network/9606.ENSP00000393776 | F-BAR domain only protein 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formati [...] |
| NKIRAS1 protein network | https://string-db.org/network/9606.ENSP00000393785 | NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (N [...] |
| ZNF512B protein network | https://string-db.org/network/9606.ENSP00000393795 | Zinc finger protein 512B; May be involved in transcriptional regulation |
| PPP1R3G protein network | https://string-db.org/network/9606.ENSP00000393832 | Protein phosphatase 1 regulatory subunit 3G; Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feed [...] |
| ZNF506 protein network | https://string-db.org/network/9606.ENSP00000393835 | Zinc finger protein 506; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| BLOC1S3 protein network | https://string-db.org/network/9606.ENSP00000393840 | Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| PPIAL4G protein network | https://string-db.org/network/9606.ENSP00000393845 | Peptidyl-prolyl cis-trans isomerase A-like 4G; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...] |
| PLA2G10 protein network | https://string-db.org/network/9606.ENSP00000393847 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cel [...] |
| CENPBD1 protein network | https://string-db.org/network/9606.ENSP00000393854 | CENPB DNA-binding domain-containing protein 1; Helix-turn-helix CENPB type domain containing |
| ZNF655 protein network | https://string-db.org/network/9606.ENSP00000393876 | Zinc finger protein 655; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| AHSG protein network | https://string-db.org/network/9606.ENSP00000393887 | Alpha-2-HS-glycoprotein; Promotes endocytosis, possesses opsonic properties and influences the mineral phase of bone. Shows affinity for calcium and barium ions; Cystatins, type 4 |
| OR5K2 protein network | https://string-db.org/network/9606.ENSP00000393889 | Olfactory receptor 5K2; Odorant receptor; Olfactory receptors, family 5 |
| RUSC2 protein network | https://string-db.org/network/9606.ENSP00000393922 | Iporin; RUN and SH3 domain containing 2 |
| TTC39A protein network | https://string-db.org/network/9606.ENSP00000393952 | Tetratricopeptide repeat domain containing |
| KIFC1 protein network | https://string-db.org/network/9606.ENSP00000393963 | Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles (By similarity). Regulate [...] |
| PRKD2 protein network | https://string-db.org/network/9606.ENSP00000393978 | Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in [...] |
| FAM19A2 protein network | https://string-db.org/network/9606.ENSP00000393987 | Protein FAM19A2; Family with sequence similarity 19 member A2, C-C motif chemokine like |
| KCNK2 protein network | https://string-db.org/network/9606.ENSP00000394033 | Potassium channel subfamily K member 2; Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a v [...] |
| SLA protein network | https://string-db.org/network/9606.ENSP00000394049 | Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved [...] |
| NOSTRIN protein network | https://string-db.org/network/9606.ENSP00000394051 | Nostrin; Nitric oxide synthase trafficking; F-BAR domain containing |
| GDI1 protein network | https://string-db.org/network/9606.ENSP00000394071 | Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Prom [...] |
| LRRC74B protein network | https://string-db.org/network/9606.ENSP00000394078 | Leucine-rich repeat-containing protein 74B; Leucine rich repeat containing 74B |
| JMJD6 protein network | https://string-db.org/network/9606.ENSP00000394085 | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes [...] |
| ENSG00000249209 protein network | https://string-db.org/network/9606.ENSP00000394107 | annotation not available |
| SLCO1B7 protein network | https://string-db.org/network/9606.ENSP00000394168 | Solute carrier organic anion transporter family member 1B7 |
| TMEM182 protein network | https://string-db.org/network/9606.ENSP00000394178 | Transmembrane protein 182 |
| CDKN2AIPNL protein network | https://string-db.org/network/9606.ENSP00000394183 | CDKN2AIP N-terminal-like protein; CDKN2A interacting protein N-terminal like |
| CSF2RA protein network | https://string-db.org/network/9606.ENSP00000394227 | Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proli [...] |
| ZNF716 protein network | https://string-db.org/network/9606.ENSP00000394248 | Zinc finger protein 716; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR4F3 protein network | https://string-db.org/network/9606.ENSP00000394282 | Olfactory receptor, family 4, subfamily F, member 3; Odorant receptor; Olfactory receptors, family 4 |
| BZW1 protein network | https://string-db.org/network/9606.ENSP00000394316 | Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly |
| COMMD5 protein network | https://string-db.org/network/9606.ENSP00000394331 | COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase tra [...] |
| DIXDC1 protein network | https://string-db.org/network/9606.ENSP00000394352 | Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2; Belongs to the DIXDC1 family |
| ZNF625 protein network | https://string-db.org/network/9606.ENSP00000394380 | Zinc finger protein 625; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| KCTD15 protein network | https://string-db.org/network/9606.ENSP00000394390 | BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activ [...] |
| ANAPC7 protein network | https://string-db.org/network/9606.ENSP00000394394 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...] |
| MORF4L2 protein network | https://string-db.org/network/9606.ENSP00000394417 | Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosoma [...] |
| BTBD18 protein network | https://string-db.org/network/9606.ENSP00000394472 | BTB/POZ domain-containing protein 18; Specifically required during spermatogenesis to promote expression of piRNA precursors. The piRNA metabolic process mediates the repression of transposable e [...] |
| DCLK3 protein network | https://string-db.org/network/9606.ENSP00000394484 | Serine/threonine-protein kinase DCLK3; Doublecortin like kinase 3; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily |
| PDZK1 protein network | https://string-db.org/network/9606.ENSP00000394485 | Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apica [...] |
| FGD4 protein network | https://string-db.org/network/9606.ENSP00000394487 | FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the ac [...] |
| CORO1C protein network | https://string-db.org/network/9606.ENSP00000394496 | Coronin-1C; May be involved in cytokinesis, motility, and signal transduction; Belongs to the WD repeat coronin family |
| PRR12 protein network | https://string-db.org/network/9606.ENSP00000394510 | Proline-rich protein 12; Proline rich 12 |
| NHSL1 protein network | https://string-db.org/network/9606.ENSP00000394546 | NHS-like protein 1; NHS like 1; Belongs to the NHS family |
| MAPK9 protein network | https://string-db.org/network/9606.ENSP00000394560 | Mitogen-activated protein kinase 9; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. [...] |
| NUTM2B protein network | https://string-db.org/network/9606.ENSP00000394623 | NUT family member 2B |
| OPRM1 protein network | https://string-db.org/network/9606.ENSP00000394624 | Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, [...] |
| SEMA4B protein network | https://string-db.org/network/9606.ENSP00000394720 | Semaphorin-4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Semaphorins |
| CLK1 protein network | https://string-db.org/network/9606.ENSP00000394734 | Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spl [...] |
| IPCEF1 protein network | https://string-db.org/network/9606.ENSP00000394751 | Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner; Pleckstrin homology domain contain [...] |
| ZNF516 protein network | https://string-db.org/network/9606.ENSP00000394757 | Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose ti [...] |
| CMYA5 protein network | https://string-db.org/network/9606.ENSP00000394770 | Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May functio [...] |
| SENP1 protein network | https://string-db.org/network/9606.ENSP00000394791 | Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ub [...] |
| PTPN13 protein network | https://string-db.org/network/9606.ENSP00000394794 | Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS- induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide [...] |
| GCA protein network | https://string-db.org/network/9606.ENSP00000394842 | Grancalcin; Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions; EF-hand domain containing |
| PPT1 protein network | https://string-db.org/network/9606.ENSP00000394863 | Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl c [...] |
| EIF2B4 protein network | https://string-db.org/network/9606.ENSP00000394869 | Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP |
| DOCK8 protein network | https://string-db.org/network/9606.ENSP00000394888 | Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, require [...] |
| TMEM51 protein network | https://string-db.org/network/9606.ENSP00000394899 | Transmembrane protein 51 |
| ORM2 protein network | https://string-db.org/network/9606.ENSP00000394936 | Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influ [...] |
| GSG1L protein network | https://string-db.org/network/9606.ENSP00000394954 | Germ cell-specific gene 1-like protein; As a component of the inner core of AMPAR complex, modifies AMPA receptor (AMPAR) gating |
| ZNF746 protein network | https://string-db.org/network/9606.ENSP00000395007 | Zinc finger protein 746; Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby play [...] |
| KLHL24 protein network | https://string-db.org/network/9606.ENSP00000395012 | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubi [...] |
| ARFIP1 protein network | https://string-db.org/network/9606.ENSP00000395083 | Arfaptin-1; Putative target protein of ADP-ribosylation factor; Classical BAR domain containing |
| TRIM51 protein network | https://string-db.org/network/9606.ENSP00000395086 | Tripartite motif-containing 51; Ring finger proteins |
| EARS2 protein network | https://string-db.org/network/9606.ENSP00000395196 | Probable glutamate--tRNA ligase, mitochondrial; Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred [...] |
| TMEM68 protein network | https://string-db.org/network/9606.ENSP00000395204 | Transmembrane protein 68 |
| IGFL2 protein network | https://string-db.org/network/9606.ENSP00000395219 | Insulin growth factor-like family member 2; Potential ligand of the IGFLR1 cell membrane receptor |
| SYTL5 protein network | https://string-db.org/network/9606.ENSP00000395220 | Synaptotagmin-like protein 5; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids; Synaptotagmin like tandem C2 proteins |
| MTFR2 protein network | https://string-db.org/network/9606.ENSP00000395232 | Mitochondrial fission regulator 2; May play a role in mitochondrial aerobic respiration essentially in the testis. Can also promote mitochondrial fission (By similarity); Belongs to the MTFR1 fam [...] |
| TMEM229A protein network | https://string-db.org/network/9606.ENSP00000395244 | Transmembrane protein 229A |
| FAM134A protein network | https://string-db.org/network/9606.ENSP00000395249 | Reticulophagy regulator 2; Family with sequence similarity 134, member A; Belongs to the RETREG family |
| ZBED9 protein network | https://string-db.org/network/9606.ENSP00000395259 | SCAN domain-containing protein 3; Zinc finger BED-type containing 9; SCAN domain containing |
| C9orf116 protein network | https://string-db.org/network/9606.ENSP00000395281 | UPF0691 protein C9orf116; Chromosome 9 open reading frame 116 |
| FAM185A protein network | https://string-db.org/network/9606.ENSP00000395340 | Protein FAM185A; Family with sequence similarity 185 member A |
| LPAR3 protein network | https://string-db.org/network/9606.ENSP00000395389 | Lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to [...] |
| BTBD19 protein network | https://string-db.org/network/9606.ENSP00000395461 | BTB/POZ domain-containing protein 19; BTB domain containing 19 |
| MAN2B1 protein network | https://string-db.org/network/9606.ENSP00000395473 | Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover. Cleaves all known types of alpha-mannosidic linkages; Belongs to the gly [...] |
| SNX10 protein network | https://string-db.org/network/9606.ENSP00000395474 | Sorting nexin-10; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transpor [...] |
| PATE3 protein network | https://string-db.org/network/9606.ENSP00000395505 | Prostate and testis expressed 3; Belongs to the PATE family |
| MECP2 protein network | https://string-db.org/network/9606.ENSP00000395535 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. M [...] |
| TNRC18 protein network | https://string-db.org/network/9606.ENSP00000395538 | Trinucleotide repeat-containing gene 18 protein; Trinucleotide repeat containing 18 |
| TCEB3 protein network | https://string-db.org/network/9606.ENSP00000395574 | Elongin-A; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...] |
| IFI35 protein network | https://string-db.org/network/9606.ENSP00000395590 | Interferon-induced 35 kDa protein; Not yet known |
| ZNF812 protein network | https://string-db.org/network/9606.ENSP00000395629 | Zinc finger protein 812 |
| SMARCA4 protein network | https://string-db.org/network/9606.ENSP00000395654 | Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin [...] |
| CXCR6 protein network | https://string-db.org/network/9606.ENSP00000395704 | C-X-C chemokine receptor type 6; Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1 |
| RAPGEF3 protein network | https://string-db.org/network/9606.ENSP00000395708 | Rap guanine nucleotide exchange factor 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RA [...] |
| ZNF200 protein network | https://string-db.org/network/9606.ENSP00000395723 | Zinc finger protein 200; Could have a role in spermatogenesis; Zinc fingers C2H2-type |
| ZNF737 protein network | https://string-db.org/network/9606.ENSP00000395733 | Zinc finger protein 737; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GNL3 protein network | https://string-db.org/network/9606.ENSP00000395772 | Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradatio [...] |
| CCDC129 protein network | https://string-db.org/network/9606.ENSP00000395835 | Coiled-coil domain containing 129 |
| NSD1 protein network | https://string-db.org/network/9606.ENSP00000395929 | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Tran [...] |
| SLC12A4 protein network | https://string-db.org/network/9606.ENSP00000395983 | Solute carrier family 12 member 4; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involv [...] |
| CCDC141 protein network | https://string-db.org/network/9606.ENSP00000395995 | Coiled-coil domain-containing protein 141; Plays a critical role in radial migration and centrosomal function; Immunoglobulin like domain containing |
| PLA2G4B protein network | https://string-db.org/network/9606.ENSP00000396045 | Cytosolic phospholipase A2 beta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a m [...] |
| BRMS1 protein network | https://string-db.org/network/9606.ENSP00000396052 | Breast cancer metastasis-suppressor 1; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding [...] |
| UBR3 protein network | https://string-db.org/network/9606.ENSP00000396068 | E3 ubiquitin-protein ligase UBR3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Does not bind to proteins bearing specific N-terminal residues that a [...] |
| OR6V1 protein network | https://string-db.org/network/9606.ENSP00000396085 | Olfactory receptor 6V1; Odorant receptor; Olfactory receptors, family 6 |
| MYT1L protein network | https://string-db.org/network/9606.ENSP00000396103 | Myelin transcription factor 1-like protein; Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non- neuronal genes during neuron diffe [...] |
| FBRSL1 protein network | https://string-db.org/network/9606.ENSP00000396160 | Fibrosin-1-like protein; Fibrosin like 1; Belongs to the AUTS2 family |
| CLEC2A protein network | https://string-db.org/network/9606.ENSP00000396163 | C-type lectin domain family 2 member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced e [...] |
| KIAA0141 protein network | https://string-db.org/network/9606.ENSP00000396225 | Death ligand signal enhancer; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation |
| DEPDC4 protein network | https://string-db.org/network/9606.ENSP00000396234 | DEP domain containing 4 |
| TSPAN14 protein network | https://string-db.org/network/9606.ENSP00000396270 | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10- mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated c [...] |
| IK protein network | https://string-db.org/network/9606.ENSP00000396301 | Protein Red; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progr [...] |
| CLDN25 protein network | https://string-db.org/network/9606.ENSP00000396304 | Putative claudin-25; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| DHFR protein network | https://string-db.org/network/9606.ENSP00000396308 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine [...] |
| SCN4A protein network | https://string-db.org/network/9606.ENSP00000396320 | Sodium channel protein type 4 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...] |
| ZNF302 protein network | https://string-db.org/network/9606.ENSP00000396379 | Zinc finger protein 302; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF793 protein network | https://string-db.org/network/9606.ENSP00000396402 | Zinc finger protein 793; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NXPE3 protein network | https://string-db.org/network/9606.ENSP00000396421 | NXPE family member 3; Neurexophilin and PC-esterase domain family member 3 |
| GPATCH4 protein network | https://string-db.org/network/9606.ENSP00000396441 | G-patch domain containing 4 |
| OSGIN2 protein network | https://string-db.org/network/9606.ENSP00000396445 | Oxidative stress-induced growth inhibitor 2; May be involved in meiosis or the maturation of germ cells |
| HDHD1 protein network | https://string-db.org/network/9606.ENSP00000396452 | Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine; Belongs to the HAD-like hy [...] |
| MAPKAPK3 protein network | https://string-db.org/network/9606.ENSP00000396467 | MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional reg [...] |
| SLC35G6 protein network | https://string-db.org/network/9606.ENSP00000396523 | Solute carrier family 35 member G6 |
| ENSG00000249319 protein network | https://string-db.org/network/9606.ENSP00000396527 | annotation not available |
| DYTN protein network | https://string-db.org/network/9606.ENSP00000396593 | Dystrotelin; Zinc fingers ZZ-type |
| GLB1L3 protein network | https://string-db.org/network/9606.ENSP00000396615 | Beta-galactosidase-1-like protein 3; Galactosidase beta 1 like 3 |
| NFYC protein network | https://string-db.org/network/9606.ENSP00000396620 | Nuclear transcription factor Y subunit gamma; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'- CCAAT-3' box motif found in the pro [...] |
| MROH7 protein network | https://string-db.org/network/9606.ENSP00000396622 | Maestro heat like repeat family member 7 |
| TEX264 protein network | https://string-db.org/network/9606.ENSP00000396628 | Testis-expressed protein 264; Testis expressed 264 |
| PRR23C protein network | https://string-db.org/network/9606.ENSP00000396648 | Proline-rich protein 23C; Proline rich 23C; Belongs to the PRR23 family |
| FTSJ3 protein network | https://string-db.org/network/9606.ENSP00000396673 | pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation; Belongs to the class I-like SAM-bi [...] |
| C4A protein network | https://string-db.org/network/9606.ENSP00000396688 | Complement C4-A; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune comple [...] |
| TOP2B protein network | https://string-db.org/network/9606.ENSP00000396704 | DNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks; Belongs to the type II t [...] |
| NTM protein network | https://string-db.org/network/9606.ENSP00000396722 | Neurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family |
| PRDM7 protein network | https://string-db.org/network/9606.ENSP00000396732 | Probable histone-lysine N-methyltransferase PRDM7; Probable histone methyltransferase; PR/SET domain family |
| ANKRD60 protein network | https://string-db.org/network/9606.ENSP00000396747 | Ankyrin repeat domain-containing protein 60; Ankyrin repeat domain containing |
| KANSL3 protein network | https://string-db.org/network/9606.ENSP00000396749 | KAT8 regulatory NSL complex subunit 3; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...] |
| CNTD2 protein network | https://string-db.org/network/9606.ENSP00000396755 | Cyclin N-terminal domain containing 2 |
| NFIC protein network | https://string-db.org/network/9606.ENSP00000396843 | Nuclear factor 1 C-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These [...] |
| ZNF697 protein network | https://string-db.org/network/9606.ENSP00000396857 | Zinc finger protein 697; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DNAJC4 protein network | https://string-db.org/network/9606.ENSP00000396896 | DnaJ heat shock protein family member C4 |
| SCN1B protein network | https://string-db.org/network/9606.ENSP00000396915 | Sodium channel subunit beta-1; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha s [...] |
| URGCP protein network | https://string-db.org/network/9606.ENSP00000396918 | Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) [...] |
| KIAA0226L protein network | https://string-db.org/network/9606.ENSP00000396935 | Protein RUBCNL-like; May act as a tumor suppressor |
| PRR29 protein network | https://string-db.org/network/9606.ENSP00000396936 | Proline-rich protein 29; Proline rich 29 |
| PSMD13 protein network | https://string-db.org/network/9606.ENSP00000396937 | Proteasome 26S subunit, non-ATPase 13 |
| ATF5 protein network | https://string-db.org/network/9606.ENSP00000396954 | Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP resp [...] |
| BAHD1 protein network | https://string-db.org/network/9606.ENSP00000396976 | Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. [...] |
| PAPD5 protein network | https://string-db.org/network/9606.ENSP00000396995 | Non-canonical poly(A) RNA polymerase PAPD5; Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechan [...] |
| TEX22 protein network | https://string-db.org/network/9606.ENSP00000397002 | Testis-expressed protein 22; Testis expressed 22 |
| GRIK2 protein network | https://string-db.org/network/9606.ENSP00000397026 | Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitato [...] |
| SMIM34A protein network | https://string-db.org/network/9606.ENSP00000397039 | annotation not available |
| PPM1N protein network | https://string-db.org/network/9606.ENSP00000397050 | Belongs to the PP2C family |
| TRIM10 protein network | https://string-db.org/network/9606.ENSP00000397073 | Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis; Belongs to the TRIM/RBCC family |
| SFTPA1 protein network | https://string-db.org/network/9606.ENSP00000397082 | Pulmonary surfactant-associated protein A1; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveo [...] |
| GAGE12C protein network | https://string-db.org/network/9606.ENSP00000397103 | G antigen 12C; Belongs to the GAGE family |
| PRKAG3 protein network | https://string-db.org/network/9606.ENSP00000397133 | 5'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energ [...] |
| PERP protein network | https://string-db.org/network/9606.ENSP00000397157 | P53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. P [...] |
| BLCAP protein network | https://string-db.org/network/9606.ENSP00000397172 | Bladder cancer-associated protein; May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B |
| ZNF300 protein network | https://string-db.org/network/9606.ENSP00000397178 | Zinc finger protein 300; Has a transcriptional repressor activity; Zinc fingers C2H2-type |
| RGS4 protein network | https://string-db.org/network/9606.ENSP00000397181 | Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on [...] |
| FAM104B protein network | https://string-db.org/network/9606.ENSP00000397188 | Family with sequence similarity 104 member B |
| KDM4E protein network | https://string-db.org/network/9606.ENSP00000397239 | Lysine-specific demethylase 4E; Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code; Lysine demethylases |
| BZW2 protein network | https://string-db.org/network/9606.ENSP00000397249 | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation |
| ATXN7L3 protein network | https://string-db.org/network/9606.ENSP00000397259 | Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediatin [...] |
| SELENBP1 protein network | https://string-db.org/network/9606.ENSP00000397261 | Selenium-binding protein 1; Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity [...] |
| NTF3 protein network | https://string-db.org/network/9606.ENSP00000397297 | Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family |
| LRRN3 protein network | https://string-db.org/network/9606.ENSP00000397312 | Leucine-rich repeat neuronal protein 3; Fibronectin type III domain containing |
| GRID2IP protein network | https://string-db.org/network/9606.ENSP00000397351 | Delphilin; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules; PDZ domain cont [...] |
| C19orf25 protein network | https://string-db.org/network/9606.ENSP00000397394 | UPF0449 protein C19orf25; Chromosome 19 open reading frame 25; Belongs to the UPF0449 family |
| TSEN34 protein network | https://string-db.org/network/9606.ENSP00000397402 | tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the spli [...] |
| RLN3 protein network | https://string-db.org/network/9606.ENSP00000397415 | Relaxin-3; May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142); Belongs to the insulin family |
| TSC22D1 protein network | https://string-db.org/network/9606.ENSP00000397435 | TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter |
| COG6 protein network | https://string-db.org/network/9606.ENSP00000397441 | Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function; Components of oligomeric golgi complex |
| UBE2W protein network | https://string-db.org/network/9606.ENSP00000397453 | Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrat [...] |
| DUSP22 protein network | https://string-db.org/network/9606.ENSP00000397459 | Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK) (By simi [...] |
| ACTL6A protein network | https://string-db.org/network/9606.ENSP00000397552 | Actin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remode [...] |
| PAPD4 protein network | https://string-db.org/network/9606.ENSP00000397563 | Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly [...] |
| GTF2IRD1 protein network | https://string-db.org/network/9606.ENSP00000397566 | General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I tr [...] |
| KY protein network | https://string-db.org/network/9606.ENSP00000397598 | Kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by [...] |
| ASB15 protein network | https://string-db.org/network/9606.ENSP00000397655 | Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| ALKBH8 protein network | https://string-db.org/network/9606.ENSP00000397673 | Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its met [...] |
| ENDOU protein network | https://string-db.org/network/9606.ENSP00000397679 | Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini; Serine proteases |
| ZNF28 protein network | https://string-db.org/network/9606.ENSP00000397693 | Zinc finger protein 28; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RPL17 protein network | https://string-db.org/network/9606.ENSP00000397798 | 60S ribosomal protein L17; Component of the large ribosomal subunit; Belongs to the universal ribosomal protein uL22 family |
| TMA7 protein network | https://string-db.org/network/9606.ENSP00000397843 | Translation machinery associated 7 homolog |
| IL34 protein network | https://string-db.org/network/9606.ENSP00000397863 | Interleukin-34; Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an impor [...] |
| PET117 protein network | https://string-db.org/network/9606.ENSP00000397881 | Protein PET117 homolog, mitochondrial; PET117 homolog |
| MRO protein network | https://string-db.org/network/9606.ENSP00000397900 | Maestro heat like repeat containing |
| LPIN1 protein network | https://string-db.org/network/9606.ENSP00000397908 | Phosphatidate phosphatase LPIN1; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catal [...] |
| SP140L protein network | https://string-db.org/network/9606.ENSP00000397911 | SP140 nuclear body protein like; Bromodomain containing |
| ATP2C2 protein network | https://string-db.org/network/9606.ENSP00000397925 | Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium; ATPases Ca2+ transporting |
| POLDIP3 protein network | https://string-db.org/network/9606.ENSP00000397927 | Polymerase delta-interacting protein 3; Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA trans [...] |
| ENSG00000249240 protein network | https://string-db.org/network/9606.ENSP00000397942 | Uncharacterized protein |
| PLEKHA8 protein network | https://string-db.org/network/9606.ENSP00000397947 | Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) [...] |
| LOC728763 protein network | https://string-db.org/network/9606.ENSP00000397968 | Putative ciliary rootlet coiled-coil protein 2; Protein LOC728763 ; Belongs to the rootletin family |
| CLDN9 protein network | https://string-db.org/network/9606.ENSP00000398017 | Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| ALPK1 protein network | https://string-db.org/network/9606.ENSP00000398048 | Alpha-protein kinase 1; Kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation |
| HIGD1A protein network | https://string-db.org/network/9606.ENSP00000398064 | HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the [...] |
| ATP9B protein network | https://string-db.org/network/9606.ENSP00000398076 | Probable phospholipid-transporting ATPase IIB; ATPase phospholipid transporting 9B |
| TMEM243 protein network | https://string-db.org/network/9606.ENSP00000398083 | Transmembrane protein 243; Belongs to the TMEM243 family |
| ZNF821 protein network | https://string-db.org/network/9606.ENSP00000398089 | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CHAC1 protein network | https://string-db.org/network/9606.ENSP00000398105 | Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamm [...] |
| ZBED5 protein network | https://string-db.org/network/9606.ENSP00000398106 | Zinc finger BED-type containing 5 |
| E2F5 protein network | https://string-db.org/network/9606.ENSP00000398124 | Transcription factor E2F5; Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate [...] |
| GSPT1 protein network | https://string-db.org/network/9606.ENSP00000398131 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Inv [...] |
| ALKBH2 protein network | https://string-db.org/network/9606.ENSP00000398181 | DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containi [...] |
| TTC21A protein network | https://string-db.org/network/9606.ENSP00000398211 | Tetratricopeptide repeat domain containing; Belongs to the TTC21 family |
| SOX5 protein network | https://string-db.org/network/9606.ENSP00000398273 | Transcription factor SOX-5; Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro; SRY-boxes |
| PPP1R14D protein network | https://string-db.org/network/9606.ENSP00000398342 | Protein phosphatase 1 regulatory subunit 14D; Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1C [...] |
| C11orf68 protein network | https://string-db.org/network/9606.ENSP00000398350 | UPF0696 protein C11orf68; Chromosome 11 open reading frame 68; Belongs to the UPF0696 family |
| FAM133B protein network | https://string-db.org/network/9606.ENSP00000398401 | Protein FAM133B; Family with sequence similarity 133 member B |
| KDM8 protein network | https://string-db.org/network/9606.ENSP00000398410 | JmjC domain-containing protein 5; Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repre [...] |
| CADPS2 protein network | https://string-db.org/network/9606.ENSP00000398481 | Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogen [...] |
| DIABLO protein network | https://string-db.org/network/9606.ENSP00000398495 | Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins [...] |
| FAM86A protein network | https://string-db.org/network/9606.ENSP00000398502 | Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525' |
| L3MBTL1 protein network | https://string-db.org/network/9606.ENSP00000398516 | Lethal(3)malignant brain tumor-like protein 1; Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader [...] |
| CALCOCO2 protein network | https://string-db.org/network/9606.ENSP00000398523 | Calcium-binding and coiled-coil domain-containing protein 2; Xenophagy-specific receptor required for autophagy- mediated intracellular bacteria degradation. Acts as an effector protein of galect [...] |
| ENSG00000256349 protein network | https://string-db.org/network/9606.ENSP00000398526 | Bardet-Biedl syndrome 1 protein |
| CT47A3 protein network | https://string-db.org/network/9606.ENSP00000398559 | Cancer/testis antigen family 47, member A3 |
| SPATA13 protein network | https://string-db.org/network/9606.ENSP00000398560 | Spermatogenesis-associated protein 13; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a [...] |
| PRF1 protein network | https://string-db.org/network/9606.ENSP00000398568 | Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recogniz [...] |
| TAMM41 protein network | https://string-db.org/network/9606.ENSP00000398596 | Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosyn [...] |
| EXOSC6 protein network | https://string-db.org/network/9606.ENSP00000398597 | Exosome complex component MTR3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degrada [...] |
| ANXA11 protein network | https://string-db.org/network/9606.ENSP00000398610 | Annexin A11; Binds specifically to calcyclin in a calcium-dependent manner (By similarity). Required for midbody formation and completion of the terminal phase of cytokinesis; Belongs to the anne [...] |
| FAM71E2 protein network | https://string-db.org/network/9606.ENSP00000398617 | Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family |
| KRTAP25-1 protein network | https://string-db.org/network/9606.ENSP00000398619 | Keratin-associated protein 25-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| CD44 protein network | https://string-db.org/network/9606.ENSP00000398632 | CD44 antigen; Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as oste [...] |
| ARL13A protein network | https://string-db.org/network/9606.ENSP00000398637 | ADP-ribosylation factor-like protein 13A; ADP ribosylation factor like GTPase 13A; ARF GTPase family |
| ITK protein network | https://string-db.org/network/9606.ENSP00000398655 | Tyrosine-protein kinase ITK/TSK; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventiona [...] |
| VWA5B2 protein network | https://string-db.org/network/9606.ENSP00000398688 | Von Willebrand factor A domain containing 5B2 |
| TNF protein network | https://string-db.org/network/9606.ENSP00000398698 | Tumor necrosis factor; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen c [...] |
| CHID1 protein network | https://string-db.org/network/9606.ENSP00000398722 | Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length o [...] |
| CYR61 protein network | https://string-db.org/network/9606.ENSP00000398736 | Protein CYR61; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number [...] |
| ADAL protein network | https://string-db.org/network/9606.ENSP00000398744 | Adenosine deaminase-like protein; Putative nucleoside deaminase. May catalyze the hydrolytic deamination of adenosine or some similar substrate and play a role in purine metabolism (By similarity [...] |
| RELL1 protein network | https://string-db.org/network/9606.ENSP00000398778 | RELT-like protein 1; RELT family; Belongs to the RELT family |
| SNX13 protein network | https://string-db.org/network/9606.ENSP00000398789 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis (By similarity). Acts as a GAP for Galphas; Belongs to the sorting nexin [...] |
| ZNF142 protein network | https://string-db.org/network/9606.ENSP00000398798 | Zinc finger protein 142; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TSTA3 protein network | https://string-db.org/network/9606.ENSP00000398803 | GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogena [...] |
| PHF21A protein network | https://string-db.org/network/9606.ENSP00000398824 | PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE s [...] |
| KMT2B protein network | https://string-db.org/network/9606.ENSP00000398837 | Histone-lysine N-methyltransferase 2B; Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Pla [...] |
| IP6K3 protein network | https://string-db.org/network/9606.ENSP00000398861 | Inositol hexakisphosphate kinase 3; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4; B [...] |
| CDK12 protein network | https://string-db.org/network/9606.ENSP00000398880 | Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of trans [...] |
| DOHH protein network | https://string-db.org/network/9606.ENSP00000398882 | Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5 [...] |
| HLA-DMB protein network | https://string-db.org/network/9606.ENSP00000398890 | HLA class II histocompatibility antigen, DM beta chain; Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II m [...] |
| SGCE protein network | https://string-db.org/network/9606.ENSP00000398930 | Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix |
| CNTNAP5 protein network | https://string-db.org/network/9606.ENSP00000399013 | Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellu [...] |
| C18orf42 protein network | https://string-db.org/network/9606.ENSP00000399075 | A-kinase anchor protein inhibitor 1; Protein kinase A (PKA)-binding protein. Binds to type II regulatory subunits of protein kinase A (PKA) and may block the A- kinase anchoring protein (AKAP)-me [...] |
| OR10J1 protein network | https://string-db.org/network/9606.ENSP00000399078 | Olfactory receptor 10J1; Odorant receptor; Olfactory receptors, family 10 |
| SLC6A12 protein network | https://string-db.org/network/9606.ENSP00000399136 | Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic [...] |
| HLA-B protein network | https://string-db.org/network/9606.ENSP00000399168 | HLA class I histocompatibility antigen, B-7 alpha chain; Involved in the presentation of foreign antigens to the immune system; C1-set domain containing |
| MXRA8 protein network | https://string-db.org/network/9606.ENSP00000399229 | Matrix remodeling-associated protein 8; May play a role in the maturation and maintenance of blood-brain barrier; V-set domain containing |
| FCHSD1 protein network | https://string-db.org/network/9606.ENSP00000399259 | FCH and double SH3 domains 1; F-BAR domain containing |
| FGF16 protein network | https://string-db.org/network/9606.ENSP00000399324 | Fibroblast growth factor 16; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferatio [...] |
| CT62 protein network | https://string-db.org/network/9606.ENSP00000399356 | Cancer/testis antigen 62 |
| C3orf52 protein network | https://string-db.org/network/9606.ENSP00000399392 | TPA-induced transmembrane protein; Chromosome 3 open reading frame 52 |
| KLC2 protein network | https://string-db.org/network/9606.ENSP00000399403 | Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...] |
| CCBL1 protein network | https://string-db.org/network/9606.ENSP00000399415 | Kynurenine--oxoglutarate transaminase 1; Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of [...] |
| CD36 protein network | https://string-db.org/network/9606.ENSP00000399421 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyl [...] |
| LRRC70 protein network | https://string-db.org/network/9606.ENSP00000399441 | Leucine-rich repeat-containing protein 70; Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS) |
| DDOST protein network | https://string-db.org/network/9606.ENSP00000399457 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose o [...] |
| ATF7 protein network | https://string-db.org/network/9606.ENSP00000399465 | Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present i [...] |
| JMJD8 protein network | https://string-db.org/network/9606.ENSP00000399475 | JmjC domain-containing protein 8; Jumonji domain containing 8 |
| LY6H protein network | https://string-db.org/network/9606.ENSP00000399485 | Lymphocyte antigen 6H; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. May play a role [...] |
| TNIK protein network | https://string-db.org/network/9606.ENSP00000399511 | TRAF2 and NCK-interacting protein kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to acti [...] |
| SATB1 protein network | https://string-db.org/network/9606.ENSP00000399518 | DNA-binding protein SATB1; Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds t [...] |
| ANKRD63 protein network | https://string-db.org/network/9606.ENSP00000399547 | Ankyrin repeat domain-containing protein 63; Ankyrin repeat domain containing |
| MRS2 protein network | https://string-db.org/network/9606.ENSP00000399585 | Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial r [...] |
| GAB3 protein network | https://string-db.org/network/9606.ENSP00000399588 | GRB2-associated-binding protein 3; Pleckstrin homology domain containing |
| ZFP69B protein network | https://string-db.org/network/9606.ENSP00000399664 | Zinc finger protein ZFP69B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PRG4 protein network | https://string-db.org/network/9606.ENSP00000399679 | Proteoglycan 4; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth a [...] |
| ENSG00000248235 protein network | https://string-db.org/network/9606.ENSP00000399696 | Uncharacterized protein |
| PLAC8 protein network | https://string-db.org/network/9606.ENSP00000399700 | Placenta-specific gene 8 protein; Placenta specific 8 |
| BEST1 protein network | https://string-db.org/network/9606.ENSP00000399709 | Bestrophin-1; Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate; Bestrophins |
| CT47A6 protein network | https://string-db.org/network/9606.ENSP00000399711 | Cancer/testis antigen family 47, member A6 |
| MBIP protein network | https://string-db.org/network/9606.ENSP00000399718 | MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activ [...] |
| CHRM2 protein network | https://string-db.org/network/9606.ENSP00000399745 | Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...] |
| MOV10 protein network | https://string-db.org/network/9606.ENSP00000399797 | Putative helicase MOV-10; Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression [...] |
| CRYZ protein network | https://string-db.org/network/9606.ENSP00000399805 | Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequ [...] |
| HOXC4 protein network | https://string-db.org/network/9606.ENSP00000399808 | Homeobox protein Hox-C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| CNOT10 protein network | https://string-db.org/network/9606.ENSP00000399862 | CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA d [...] |
| ZNF839 protein network | https://string-db.org/network/9606.ENSP00000399863 | Zinc finger protein 839 |
| HMGA1 protein network | https://string-db.org/network/9606.ENSP00000399888 | High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleoso [...] |
| NBEAL1 protein network | https://string-db.org/network/9606.ENSP00000399903 | Neurobeachin-like protein 1; Armadillo-like helical domain containing; Belongs to the WD repeat neurobeachin family |
| FLYWCH1 protein network | https://string-db.org/network/9606.ENSP00000399938 | FLYWCH-type zinc finger 1 |
| NCOA2 protein network | https://string-db.org/network/9606.ENSP00000399968 | Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal dom [...] |
| PPP2R2D protein network | https://string-db.org/network/9606.ENSP00000399970 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis [...] |
| SLC52A1 protein network | https://string-db.org/network/9606.ENSP00000399979 | Solute carrier family 52, riboflavin transporter, member 1; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by ribof [...] |
| TAF6 protein network | https://string-db.org/network/9606.ENSP00000399982 | Transcription initiation factor TFIID subunit 6; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is mu [...] |
| PTPRJ protein network | https://string-db.org/network/9606.ENSP00000400010 | Receptor-type tyrosine-protein phosphatase eta; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SR [...] |
| KRTAP5-2 protein network | https://string-db.org/network/9606.ENSP00000400041 | Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| CT47A8 protein network | https://string-db.org/network/9606.ENSP00000400046 | Cancer/testis antigen family 47, member A8 |
| ASRGL1 protein network | https://string-db.org/network/9606.ENSP00000400057 | Isoaspartyl peptidase/L-asparaginase; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitt [...] |
| TEN1-CDK3 protein network | https://string-db.org/network/9606.ENSP00000400088 | TEN1-CDK3 readthrough (NMD candidate); Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. [...] |
| FAM65A protein network | https://string-db.org/network/9606.ENSP00000400099 | Rho family-interacting cell polarization regulator 1; Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter prote [...] |
| SLC25A13 protein network | https://string-db.org/network/9606.ENSP00000400101 | Calcium-binding mitochondrial carrier protein Aralar2; Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May [...] |
| ZDHHC13 protein network | https://string-db.org/network/9606.ENSP00000400113 | Palmitoyltransferase ZDHHC13; Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily |
| EWSR1 protein network | https://string-db.org/network/9606.ENSP00000400142 | RNA-binding protein EWS; Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicki [...] |
| B3GNT9 protein network | https://string-db.org/network/9606.ENSP00000400157 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 |
| ATP5MF-PTCD1 protein network | https://string-db.org/network/9606.ENSP00000400168 | ATP5J2-PTCD1 readthrough |
| RHOA protein network | https://string-db.org/network/9606.ENSP00000400175 | Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependen [...] |
| C17orf89 protein network | https://string-db.org/network/9606.ENSP00000400184 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize N [...] |
| FJX1 protein network | https://string-db.org/network/9606.ENSP00000400223 | Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching; Belongs to the FJX1/FJ family |
| DNAI2 protein network | https://string-db.org/network/9606.ENSP00000400252 | Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family |
| DLGAP2 protein network | https://string-db.org/network/9606.ENSP00000400258 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoske [...] |
| ULK3 protein network | https://string-db.org/network/9606.ENSP00000400312 | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in th [...] |
| ENSG00000251357 protein network | https://string-db.org/network/9606.ENSP00000400325 | Uncharacterized protein |
| FOXA2 protein network | https://string-db.org/network/9606.ENSP00000400341 | Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentia [...] |
| LAMA2 protein network | https://string-db.org/network/9606.ENSP00000400365 | Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development [...] |
| ERAP2 protein network | https://string-db.org/network/9606.ENSP00000400376 | Endoplasmic reticulum aminopeptidase 2; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I- binding peptides. Peptide trimming is [...] |
| ZNF146 protein network | https://string-db.org/network/9606.ENSP00000400391 | Zinc finger protein 146; Belongs to the krueppel C2H2-type zinc-finger protein family |
| HNRNPF protein network | https://string-db.org/network/9606.ENSP00000400433 | Heterogeneous nuclear ribonucleoprotein F; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo [...] |
| TPRXL protein network | https://string-db.org/network/9606.ENSP00000400448 | Tetra-peptide repeat homeobox-like; PRD class homeoboxes and pseudogenes |
| SNAP91 protein network | https://string-db.org/network/9606.ENSP00000400459 | Clathrin coat assembly protein AP180; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to i [...] |
| RPL9 protein network | https://string-db.org/network/9606.ENSP00000400467 | L ribosomal proteins |
| TMEM106C protein network | https://string-db.org/network/9606.ENSP00000400471 | Transmembrane protein 106C |
| CMTM3 protein network | https://string-db.org/network/9606.ENSP00000400482 | CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family |
| THAP5 protein network | https://string-db.org/network/9606.ENSP00000400500 | THAP domain-containing protein 5; Has sequence-specific DNA-binding activity and can function as transcriptional repressor (in vitro). May be a regulator of cell cycle: THAP5 overexpression in hu [...] |
| FASTKD1 protein network | https://string-db.org/network/9606.ENSP00000400513 | FAST kinase domain-containing protein 1, mitochondrial; FASTK mitochondrial RNA binding family |
| CCL24 protein network | https://string-db.org/network/9606.ENSP00000400533 | C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppre [...] |
| SNRPE protein network | https://string-db.org/network/9606.ENSP00000400591 | Small nuclear ribonucleoprotein E; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an import [...] |
| CASP16 protein network | https://string-db.org/network/9606.ENSP00000400592 | Caspase 16, apoptosis-related cysteine peptidase (putative) |
| PNPT1 protein network | https://string-db.org/network/9606.ENSP00000400646 | Polyribonucleotide nucleotidyltransferase 1, mitochondrial; RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides [...] |
| EXOC3L2 protein network | https://string-db.org/network/9606.ENSP00000400713 | Exocyst complex component 3-like protein 2; Armadillo-like helical domain containing; Belongs to the SEC6 family |
| GNA13 protein network | https://string-db.org/network/9606.ENSP00000400717 | Guanine nucleotide-binding protein subunit alpha-13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activat [...] |
| C1orf159 protein network | https://string-db.org/network/9606.ENSP00000400736 | Uncharacterized protein C1orf159; Chromosome 1 open reading frame 159 |
| LRRC69 protein network | https://string-db.org/network/9606.ENSP00000400803 | Leucine-rich repeat-containing protein 69; Leucine rich repeat containing 69 |
| APTX protein network | https://string-db.org/network/9606.ENSP00000400806 | Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at b [...] |
| SLC35G2 protein network | https://string-db.org/network/9606.ENSP00000400839 | Solute carrier family 35 member G2; May play a role in cell proliferation; Solute carriers |
| ZNF736 protein network | https://string-db.org/network/9606.ENSP00000400852 | Zinc finger protein 736; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| AARSD1 protein network | https://string-db.org/network/9606.ENSP00000400870 | Alanyl-tRNA editing protein Aarsd1; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) |
| ZNF234 protein network | https://string-db.org/network/9606.ENSP00000400878 | Zinc finger protein 234; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| USP17L11 protein network | https://string-db.org/network/9606.ENSP00000400880 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 11; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| CAPNS2 protein network | https://string-db.org/network/9606.ENSP00000400882 | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small s [...] |
| PPIP5K1 protein network | https://string-db.org/network/9606.ENSP00000400887 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphos [...] |
| TESPA1 protein network | https://string-db.org/network/9606.ENSP00000400892 | Protein TESPA1; Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen r [...] |
| OTOGL protein network | https://string-db.org/network/9606.ENSP00000400895 | Otogelin-like protein; Otogelin like |
| UBE2L3 protein network | https://string-db.org/network/9606.ENSP00000400906 | Ubiquitin-conjugating enzyme E2L 3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing [...] |
| MYBPC1 protein network | https://string-db.org/network/9606.ENSP00000400908 | Myosin-binding protein C, slow-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin fila [...] |
| SLAIN1 protein network | https://string-db.org/network/9606.ENSP00000400921 | SLAIN motif-containing protein 1; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elon [...] |
| SLC35G1 protein network | https://string-db.org/network/9606.ENSP00000400932 | Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing ca [...] |
| AGAP6 protein network | https://string-db.org/network/9606.ENSP00000400972 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 6; Putative GTPase-activating protein; Ankyrin repeat domain containing |
| BTD protein network | https://string-db.org/network/9606.ENSP00000400995 | Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation |
| ZNF780A protein network | https://string-db.org/network/9606.ENSP00000400997 | Zinc finger protein 780A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CAPZB protein network | https://string-db.org/network/9606.ENSP00000401010 | F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subuni [...] |
| GINS3 protein network | https://string-db.org/network/9606.ENSP00000401018 | GINS complex subunit 3 |
| HECTD2 protein network | https://string-db.org/network/9606.ENSP00000401023 | Probable E3 ubiquitin-protein ligase HECTD2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly tran [...] |
| ANKRD34C protein network | https://string-db.org/network/9606.ENSP00000401089 | Ankyrin repeat domain-containing protein 34C; Ankyrin repeat domain containing; Belongs to the ANKRD34 family |
| SATB2 protein network | https://string-db.org/network/9606.ENSP00000401112 | DNA-binding protein SATB2; Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor control [...] |
| SS18L2 protein network | https://string-db.org/network/9606.ENSP00000401115 | SS18-like protein 2; SS18 like 2; Belongs to the SS18 family |
| GAS2 protein network | https://string-db.org/network/9606.ENSP00000401145 | Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements o [...] |
| WBSCR22 protein network | https://string-db.org/network/9606.ENSP00000401191 | Probable 18S rRNA (guanine-N(7))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methy [...] |
| USP19 protein network | https://string-db.org/network/9606.ENSP00000401197 | Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn [...] |
| CTPS2 protein network | https://string-db.org/network/9606.ENSP00000401264 | CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine [...] |
| CBLL1 protein network | https://string-db.org/network/9606.ENSP00000401277 | E3 ubiquitin-protein ligase Hakai; Promotes ubiquitination of several tyrosine- phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation; Ring fi [...] |
| SHC1 protein network | https://string-db.org/network/9606.ENSP00000401303 | SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. I [...] |
| FRG2B protein network | https://string-db.org/network/9606.ENSP00000401310 | Protein FRG2-like-1; FSHD region gene 2 family member B |
| PRSS48 protein network | https://string-db.org/network/9606.ENSP00000401328 | Serine protease 48; Belongs to the peptidase S1 family |
| C16orf90 protein network | https://string-db.org/network/9606.ENSP00000401335 | Uncharacterized protein C16orf90; Chromosome 16 open reading frame 90 |
| TMEM8A protein network | https://string-db.org/network/9606.ENSP00000401338 | Post-GPI attachment to proteins factor 6; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 [...] |
| TIA1 protein network | https://string-db.org/network/9606.ENSP00000401371 | Nucleolysin TIA-1 isoform p40; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). [...] |
| LOC388813 protein network | https://string-db.org/network/9606.ENSP00000401381 | annotation not available |
| MYD88 protein network | https://string-db.org/network/9606.ENSP00000401399 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2 [...] |
| VPS53 protein network | https://string-db.org/network/9606.ENSP00000401435 | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...] |
| LDB3 protein network | https://string-db.org/network/9606.ENSP00000401437 | LIM domain-binding protein 3; LIM domain containing |
| ERN1 protein network | https://string-db.org/network/9606.ENSP00000401445 | Serine/threonine-protein kinase/endoribonuclease IRE1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The act [...] |
| RANGAP1 protein network | https://string-db.org/network/9606.ENSP00000401470 | Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state |
| TMEM232 protein network | https://string-db.org/network/9606.ENSP00000401477 | Transmembrane protein 232 |
| C11orf94 protein network | https://string-db.org/network/9606.ENSP00000401498 | Uncharacterized protein C11orf94; Chromosome 11 open reading frame 94 |
| SIGLEC6 protein network | https://string-db.org/network/9606.ENSP00000401502 | Sialic acid-binding Ig-like lectin 6; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may [...] |
| NAPRT protein network | https://string-db.org/network/9606.ENSP00000401508 | Nicotinate phosphoribosyltransferase; Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of [...] |
| STRC protein network | https://string-db.org/network/9606.ENSP00000401513 | Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia; Belongs to the stereocilin family |
| DNAH1 protein network | https://string-db.org/network/9606.ENSP00000401514 | Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the for [...] |
| ENSG00000248751 protein network | https://string-db.org/network/9606.ENSP00000401535 | Uncharacterized protein |
| RFX8 protein network | https://string-db.org/network/9606.ENSP00000401536 | DNA-binding protein RFX8; May be a transcription factor; Regulatory factor X family |
| RANBP1 protein network | https://string-db.org/network/9606.ENSP00000401564 | Ran-specific GTPase-activating protein; Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May ac [...] |
| ECD protein network | https://string-db.org/network/9606.ENSP00000401566 | Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptio [...] |
| DTHD1 protein network | https://string-db.org/network/9606.ENSP00000401597 | Death domain containing 1 |
| MYO16 protein network | https://string-db.org/network/9606.ENSP00000401633 | Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| SERPINB2 protein network | https://string-db.org/network/9606.ENSP00000401645 | Plasminogen activator inhibitor 2; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1; Belongs to the serpin family. Ov [...] |
| MYOCD protein network | https://string-db.org/network/9606.ENSP00000401678 | Myocardin; Smooth muscle cells (SM) and cardiac muscle cells- specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum resp [...] |
| PRSS42 protein network | https://string-db.org/network/9606.ENSP00000401701 | Serine protease 42; Belongs to the peptidase S1 family |
| OR5H14 protein network | https://string-db.org/network/9606.ENSP00000401706 | Olfactory receptor 5H14; Odorant receptor; Olfactory receptors, family 5 |
| GK protein network | https://string-db.org/network/9606.ENSP00000401720 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family |
| PAN2 protein network | https://string-db.org/network/9606.ENSP00000401721 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miR [...] |
| P4HA3 protein network | https://string-db.org/network/9606.ENSP00000401749 | Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family |
| CITED1 protein network | https://string-db.org/network/9606.ENSP00000401764 | Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link betwee [...] |
| C14orf2 protein network | https://string-db.org/network/9606.ENSP00000401770 | 6.8 kDa mitochondrial proteolipid; Chromosome 14 open reading frame 2 |
| PSMC6 protein network | https://string-db.org/network/9606.ENSP00000401802 | 26S proteasome regulatory subunit 10B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role i [...] |
| ACSF2 protein network | https://string-db.org/network/9606.ENSP00000401831 | Acyl-CoA synthetase family member 2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-c [...] |
| HYAL2 protein network | https://string-db.org/network/9606.ENSP00000401853 | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displ [...] |
| MXD3 protein network | https://string-db.org/network/9606.ENSP00000401867 | Max dimerization protein 3; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC t [...] |
| KBTBD8 protein network | https://string-db.org/network/9606.ENSP00000401878 | Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(K [...] |
| BMPR1B protein network | https://string-db.org/network/9606.ENSP00000401907 | Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phospho [...] |
| PRSS45 protein network | https://string-db.org/network/9606.ENSP00000401932 | Uncharacterized protein; Serine protease 45 |
| TNRC6B protein network | https://string-db.org/network/9606.ENSP00000401946 | Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translat [...] |
| ZNF223 protein network | https://string-db.org/network/9606.ENSP00000401947 | Zinc finger protein 223; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OR1M1 protein network | https://string-db.org/network/9606.ENSP00000401966 | Olfactory receptor 1M1; Odorant receptor; Olfactory receptors, family 1 |
| MAVS protein network | https://string-db.org/network/9606.ENSP00000401980 | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during vira [...] |
| SEPT4 protein network | https://string-db.org/network/9606.ENSP00000402000 | Septin-4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm [...] |
| C17orf58 protein network | https://string-db.org/network/9606.ENSP00000402020 | UPF0450 protein C17orf58; Chromosome 17 open reading frame 58 |
| PDZD2 protein network | https://string-db.org/network/9606.ENSP00000402033 | PDZ domain containing 2 |
| MTO1 protein network | https://string-db.org/network/9606.ENSP00000402038 | Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs; Belongs to the MnmG family |
| PVR protein network | https://string-db.org/network/9606.ENSP00000402060 | Poliovirus receptor; Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell cont [...] |
| WEE1 protein network | https://string-db.org/network/9606.ENSP00000402084 | Wee1-like protein kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onse [...] |
| SAMD3 protein network | https://string-db.org/network/9606.ENSP00000402092 | Sterile alpha motif domain containing 3 |
| HK1 protein network | https://string-db.org/network/9606.ENSP00000402103 | Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-pho [...] |
| C5orf66 protein network | https://string-db.org/network/9606.ENSP00000402151 | Putative uncharacterized protein C5orf66; Chromosome 5 open reading frame 66 |
| SLC12A3 protein network | https://string-db.org/network/9606.ENSP00000402152 | Solute carrier family 12 member 3; Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption. Receptor for the pr [...] |
| IQCJ protein network | https://string-db.org/network/9606.ENSP00000402153 | IQ motif containing J |
| MEF2B protein network | https://string-db.org/network/9606.ENSP00000402154 | Myocyte-specific enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Activates transcription [...] |
| VSIG1 protein network | https://string-db.org/network/9606.ENSP00000402219 | V-set and immunoglobulin domain containing 1; IgCAM CXADR-related subfamily |
| RUNX1T1 protein network | https://string-db.org/network/9606.ENSP00000402257 | Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and hist [...] |
| LACTBL1 protein network | https://string-db.org/network/9606.ENSP00000402297 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family |
| LAPTM4B protein network | https://string-db.org/network/9606.ENSP00000402301 | Lysosomal-associated transmembrane protein 4B; Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidy [...] |
| RPF2 protein network | https://string-db.org/network/9606.ENSP00000402338 | Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus |
| ZNF469 protein network | https://string-db.org/network/9606.ENSP00000402343 | Zinc finger protein 469; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| COPG2 protein network | https://string-db.org/network/9606.ENSP00000402346 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosy [...] |
| CDRT15 protein network | https://string-db.org/network/9606.ENSP00000402355 | CMT1A duplicated region transcript 15 |
| ACTA2 protein network | https://string-db.org/network/9606.ENSP00000402373 | Actin, aortic smooth muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin [...] |
| CHST15 protein network | https://string-db.org/network/9606.ENSP00000402394 | Carbohydrate sulfotransferase 15; Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroit [...] |
| TRIM48 protein network | https://string-db.org/network/9606.ENSP00000402414 | Tripartite motif containing 48; Belongs to the TRIM/RBCC family |
| GRAMD1B protein network | https://string-db.org/network/9606.ENSP00000402457 | Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding c [...] |
| CLSTN2 protein network | https://string-db.org/network/9606.ENSP00000402460 | Calsyntenin-2; May modulate calcium-mediated postsynaptic signals; Cadherin related |
| CPAMD8 protein network | https://string-db.org/network/9606.ENSP00000402505 | C3 and PZP like, alpha-2-macroglobulin domain containing 8; Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family |
| SMG1 protein network | https://string-db.org/network/9606.ENSP00000402515 | Serine/threonine-protein kinase SMG1; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q [...] |
| SENP6 protein network | https://string-db.org/network/9606.ENSP00000402527 | Sentrin-specific protease 6; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly- SUMO3 chains, but does not efficiently process [...] |
| MTMR10 protein network | https://string-db.org/network/9606.ENSP00000402537 | Myotubularin-related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a [...] |
| MDGA1 protein network | https://string-db.org/network/9606.ENSP00000402584 | MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Plays a role in t [...] |
| CPS1 protein network | https://string-db.org/network/9606.ENSP00000402608 | Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell |
| ENSG00000251537 protein network | https://string-db.org/network/9606.ENSP00000402644 | Uncharacterized protein |
| WDR83 protein network | https://string-db.org/network/9606.ENSP00000402653 | WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, lin [...] |
| TMEM177 protein network | https://string-db.org/network/9606.ENSP00000402661 | Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. |
| BHMG1 protein network | https://string-db.org/network/9606.ENSP00000402674 | Basic helix-loop-helix and HMG box domain-containing protein 1 |
| NBPF6 protein network | https://string-db.org/network/9606.ENSP00000402703 | Neuroblastoma breakpoint family member 6; NBPF member 6 |
| NR2C2AP protein network | https://string-db.org/network/9606.ENSP00000402756 | Nuclear receptor 2C2-associated protein; May act as a repressor of NR2C2-mediated transactivation by suppressing the binding between NR2C2/TR4 and the TR4-response element in target genes; Belong [...] |
| PMEL protein network | https://string-db.org/network/9606.ENSP00000402758 | Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II m [...] |
| TMEM235 protein network | https://string-db.org/network/9606.ENSP00000402790 | Transmembrane protein 235; Belongs to the PMP-22/EMP/MP20 family |
| TREML1 protein network | https://string-db.org/network/9606.ENSP00000402855 | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response; V-set domain containing |
| PLCL1 protein network | https://string-db.org/network/9606.ENSP00000402861 | Inactive phospholipase C-like protein 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidy [...] |
| C2orf74 protein network | https://string-db.org/network/9606.ENSP00000402915 | Uncharacterized protein C2orf74; Chromosome 2 open reading frame 74 |
| TBC1D5 protein network | https://string-db.org/network/9606.ENSP00000402935 | TBC1 domain family member 5; May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal [...] |
| FAM58A protein network | https://string-db.org/network/9606.ENSP00000402949 | Cyclin-Q; Activating cyclin for the cyclin-associated kinase CDK10; Belongs to the cyclin family. Cyclin-like FAM58 subfamily |
| PHTF2 protein network | https://string-db.org/network/9606.ENSP00000403042 | Putative homeodomain transcription factor 2; May play a role in transcription regulation |
| FRMD5 protein network | https://string-db.org/network/9606.ENSP00000403067 | FERM domain-containing protein 5; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail intera [...] |
| VKORC1L1 protein network | https://string-db.org/network/9606.ENSP00000403077 | Vitamin K epoxide reductase complex subunit 1 like 1 |
| SIGIRR protein network | https://string-db.org/network/9606.ENSP00000403104 | Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the T [...] |
| MFSD1 protein network | https://string-db.org/network/9606.ENSP00000403117 | Major facilitator superfamily domain containing 1 |
| TMEM233 protein network | https://string-db.org/network/9606.ENSP00000403130 | Interferon induced transmembrane protein domain containing |
| C10orf105 protein network | https://string-db.org/network/9606.ENSP00000403151 | Uncharacterized protein C10orf105; Chromosome 10 open reading frame 105 |
| RPL6 protein network | https://string-db.org/network/9606.ENSP00000403172 | 60S ribosomal protein L6; Component of the large ribosomal subunit |
| ENSG00000233438 protein network | https://string-db.org/network/9606.ENSP00000403181 | Uncharacterized protein |
| MAP10 protein network | https://string-db.org/network/9606.ENSP00000403208 | Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization o [...] |
| EMC9 protein network | https://string-db.org/network/9606.ENSP00000403210 | ER membrane protein complex subunit 9 |
| FBXO43 protein network | https://string-db.org/network/9606.ENSP00000403293 | F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyc [...] |
| ANKRD36C protein network | https://string-db.org/network/9606.ENSP00000403302 | Ankyrin repeat domain-containing protein 36C; Ankyrin repeat domain containing |
| SNRNP35 protein network | https://string-db.org/network/9606.ENSP00000403310 | Small nuclear ribonucleoprotein U11/U12 subunit 35; RNA binding motif containing |
| ARHGAP27 protein network | https://string-db.org/network/9606.ENSP00000403323 | Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an ina [...] |
| FAM126A protein network | https://string-db.org/network/9606.ENSP00000403396 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) s [...] |
| ZDHHC17 protein network | https://string-db.org/network/9606.ENSP00000403397 | Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. Palmitoylates MPP1 in erythrocytes. May be involve [...] |
| CCPG1 protein network | https://string-db.org/network/9606.ENSP00000403400 | Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibitio [...] |
| ZNF30 protein network | https://string-db.org/network/9606.ENSP00000403441 | Zinc finger protein 30; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ODF2 protein network | https://string-db.org/network/9606.ENSP00000403453 | Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and princi [...] |
| GRB7 protein network | https://string-db.org/network/9606.ENSP00000403459 | Growth factor receptor-bound protein 7; Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-st [...] |
| CC2D2A protein network | https://string-db.org/network/9606.ENSP00000403465 | Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusio [...] |
| LTA protein network | https://string-db.org/network/9606.ENSP00000403495 | Lymphotoxin-alpha; Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is prod [...] |
| BRAP protein network | https://string-db.org/network/9606.ENSP00000403524 | BRCA1-associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras respo [...] |
| GAMT protein network | https://string-db.org/network/9606.ENSP00000403536 | Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development; Belongs to the class I-like [...] |
| MRPL55 protein network | https://string-db.org/network/9606.ENSP00000403614 | Mitochondrial ribosomal protein L55 |
| SYNGAP1 protein network | https://string-db.org/network/9606.ENSP00000403636 | Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in [...] |
| DDC protein network | https://string-db.org/network/9606.ENSP00000403644 | Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine |
| TANGO2 protein network | https://string-db.org/network/9606.ENSP00000403645 | Transport and golgi organization 2 homolog |
| CGB8 protein network | https://string-db.org/network/9606.ENSP00000403649 | Choriogonadotropin subunit beta variant 2; Chorionic gonadotropin beta subunit 8; Belongs to the glycoprotein hormones subunit beta family |
| PRM2 protein network | https://string-db.org/network/9606.ENSP00000403681 | Protamine-2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex |
| NABP1 protein network | https://string-db.org/network/9606.ENSP00000403683 | SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as [...] |
| ARRB2 protein network | https://string-db.org/network/9606.ENSP00000403701 | Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous d [...] |
| USP17L10 protein network | https://string-db.org/network/9606.ENSP00000403760 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 10; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| FBXO10 protein network | https://string-db.org/network/9606.ENSP00000403802 | F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of B [...] |
| POLR2F protein network | https://string-db.org/network/9606.ENSP00000403852 | DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...] |
| PPP1R13L protein network | https://string-db.org/network/9606.ENSP00000403902 | RelA-associated inhibitor; Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV- [...] |
| ATP5SL protein network | https://string-db.org/network/9606.ENSP00000403910 | Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of [...] |
| TBCEL protein network | https://string-db.org/network/9606.ENSP00000403925 | Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability |
| EFCAB3 protein network | https://string-db.org/network/9606.ENSP00000403932 | EF-hand calcium-binding domain-containing protein 3; EF-hand calcium binding domain 3 |
| C11orf74 protein network | https://string-db.org/network/9606.ENSP00000403937 | Uncharacterized protein C11orf74; Chromosome 11 open reading frame 74 |
| TENM1 protein network | https://string-db.org/network/9606.ENSP00000403954 | Teneurin-1; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity) |
| CLDN34 protein network | https://string-db.org/network/9606.ENSP00000403980 | Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity |
| C15orf40 protein network | https://string-db.org/network/9606.ENSP00000403987 | UPF0235 protein C15orf40; Chromosome 15 open reading frame 40 |
| TMED4 protein network | https://string-db.org/network/9606.ENSP00000404042 | Transmembrane emp24 domain-containing protein 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. A [...] |
| ZSCAN9 protein network | https://string-db.org/network/9606.ENSP00000404074 | Zinc finger and SCAN domain containing 9 |
| DNAJB5 protein network | https://string-db.org/network/9606.ENSP00000404079 | DnaJ heat shock protein family member B5 |
| SMC6 protein network | https://string-db.org/network/9606.ENSP00000404092 | Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote siste [...] |
| PAX6 protein network | https://string-db.org/network/9606.ENSP00000404100 | Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic is [...] |
| OR2V1 protein network | https://string-db.org/network/9606.ENSP00000404102 | Olfactory receptor 2V1; Odorant receptor; Olfactory receptors, family 2 |
| ILF3 protein network | https://string-db.org/network/9606.ENSP00000404121 | Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-m [...] |
| IFT74 protein network | https://string-db.org/network/9606.ENSP00000404122 | Intraflagellar transport protein 74 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of [...] |
| GAGE12F protein network | https://string-db.org/network/9606.ENSP00000404123 | G antigen 12F; Belongs to the GAGE family |
| ENSG00000242852 protein network | https://string-db.org/network/9606.ENSP00000404127 | Zinc finger protein 709; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CEP170B protein network | https://string-db.org/network/9606.ENSP00000404151 | Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization |
| DOCK4 protein network | https://string-db.org/network/9606.ENSP00000404179 | Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activ [...] |
| RACGAP1 protein network | https://string-db.org/network/9606.ENSP00000404190 | Rac GTPase-activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation duri [...] |
| CKMT2 protein network | https://string-db.org/network/9606.ENSP00000404203 | Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role [...] |
| CCDC155 protein network | https://string-db.org/network/9606.ENSP00000404220 | Protein KASH5; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic in [...] |
| EFHC2 protein network | https://string-db.org/network/9606.ENSP00000404232 | EF-hand domain-containing family member C2; EF-hand domain containing 2 |
| LILRA5 protein network | https://string-db.org/network/9606.ENSP00000404236 | Leukocyte immunoglobulin-like receptor subfamily A member 5; May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition; Activatin [...] |
| ARL17B protein network | https://string-db.org/network/9606.ENSP00000404247 | ADP-ribosylation factor-like protein 17; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein traf [...] |
| VGLL4 protein network | https://string-db.org/network/9606.ENSP00000404251 | Transcription cofactor vestigial-like protein 4; May act as a specific coactivator for the mammalian TEFs; Vestigial like family |
| PRR20E protein network | https://string-db.org/network/9606.ENSP00000404281 | Proline rich 20E |
| PLEKHA5 protein network | https://string-db.org/network/9606.ENSP00000404296 | Pleckstrin homology domain containing A5 |
| ARMCX4 protein network | https://string-db.org/network/9606.ENSP00000404304 | Armadillo repeat containing, X-linked 4; Belongs to the eutherian X-chromosome-specific Armcx family |
| RPL36A protein network | https://string-db.org/network/9606.ENSP00000404375 | Ribosomal protein L36a |
| DNAJB14 protein network | https://string-db.org/network/9606.ENSP00000404381 | DnaJ homolog subfamily B member 14; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded prot [...] |
| LIMS3L protein network | https://string-db.org/network/9606.ENSP00000404432 | LIM and senescent cell antigen-like domains 3-like |
| SOHLH1 protein network | https://string-db.org/network/9606.ENSP00000404438 | Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription factor expressed in undifferentiated spermatogonia required for spermatogonial development; Basi [...] |
| NPIPB4 protein network | https://string-db.org/network/9606.ENSP00000404439 | Nuclear pore complex interacting protein family member B4 |
| CCBE1 protein network | https://string-db.org/network/9606.ENSP00000404464 | Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 fami [...] |
| BBC3 protein network | https://string-db.org/network/9606.ENSP00000404503 | Bcl-2-binding component 3; Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity; BCL2 homology region [...] |
| KRTAP21-3 protein network | https://string-db.org/network/9606.ENSP00000404517 | Keratin-associated protein 21-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| MYH13 protein network | https://string-db.org/network/9606.ENSP00000404570 | Myosin-13; Fast twitching myosin mediating the high-velocity and low-tension contractions of specific striated muscles; Myosin heavy chains |
| EZH1 protein network | https://string-db.org/network/9606.ENSP00000404658 | Histone-lysine N-methyltransferase EZH1; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repressi [...] |
| PGGT1B protein network | https://string-db.org/network/9606.ENSP00000404676 | Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of p [...] |
| SLMO1 protein network | https://string-db.org/network/9606.ENSP00000404700 | PRELI domain containing protein 3A; In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the m [...] |
| VPS8 protein network | https://string-db.org/network/9606.ENSP00000404704 | Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the puta [...] |
| NAALADL2 protein network | https://string-db.org/network/9606.ENSP00000404705 | Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2; May be catalytically inactive; Belongs to the peptidase M28 family. M28B subfamily |
| MGAT1 protein network | https://string-db.org/network/9606.ENSP00000404718 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-gly [...] |
| AKAP2 protein network | https://string-db.org/network/9606.ENSP00000404782 | A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream [...] |
| TAPBP protein network | https://string-db.org/network/9606.ENSP00000404833 | Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading); C1-set domain cont [...] |
| HEMK1 protein network | https://string-db.org/network/9606.ENSP00000404843 | HemK methyltransferase family member 1; N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L; Seven-beta-strand [...] |
| NDRG1 protein network | https://string-db.org/network/9606.ENSP00000404854 | Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- [...] |
| SCHIP1 protein network | https://string-db.org/network/9606.ENSP00000404860 | Schwannomin interacting protein 1, isoform CRA_c; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon i [...] |
| ENSG00000277669 protein network | https://string-db.org/network/9606.ENSP00000404873 | Uncharacterized protein; Nicotinate-nucleotide pyrophosphorylase [carboxylating] |
| ENSG00000124593 protein network | https://string-db.org/network/9606.ENSP00000404911 | Prickle planar cell polarity protein 4; Belongs to the prickle / espinas / testin family |
| TECPR1 protein network | https://string-db.org/network/9606.ENSP00000404923 | Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by ass [...] |
| TMEM120B protein network | https://string-db.org/network/9606.ENSP00000404991 | Transmembrane protein 120B; Necessary for efficient adipogenesis; Belongs to the TMEM120 family |
| WDR87 protein network | https://string-db.org/network/9606.ENSP00000405012 | WD repeat-containing protein 87; Armadillo-like helical domain containing |
| GSG1 protein network | https://string-db.org/network/9606.ENSP00000405032 | Germ cell-specific gene 1 protein; May cause the redistribution of PAPOLB from the cytosol to the endoplasmic reticulum |
| NOP14 protein network | https://string-db.org/network/9606.ENSP00000405068 | Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity); Belongs to the NOP [...] |
| TAS2R39 protein network | https://string-db.org/network/9606.ENSP00000405095 | Taste receptor type 2 member 39; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| DHX57 protein network | https://string-db.org/network/9606.ENSP00000405111 | Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily |
| LIMS3 protein network | https://string-db.org/network/9606.ENSP00000405165 | LIM and senescent cell antigen-like-containing domain protein 3; LIM zinc finger domain containing 3 |
| SPANXB2 protein network | https://string-db.org/network/9606.ENSP00000405202 | Sperm protein associated with the nucleus on the X chromosome B1; SPANX family, member B2 |
| SPANXN4 protein network | https://string-db.org/network/9606.ENSP00000405210 | Sperm protein associated with the nucleus on the X chromosome N4; SPANX family member N4; Belongs to the SPAN-X family |
| ZNF347 protein network | https://string-db.org/network/9606.ENSP00000405218 | Zinc finger protein 347; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DCAF8L1 protein network | https://string-db.org/network/9606.ENSP00000405222 | DDB1- and CUL4-associated factor 8-like protein 1; DDB1 and CUL4 associated factor 8 like 1; Belongs to the WD repeat DCAF8 family |
| AKAP7 protein network | https://string-db.org/network/9606.ENSP00000405252 | A-kinase anchor protein 7 isoform gamma; Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane- associated form reduces epithelial [...] |
| ZNF778 protein network | https://string-db.org/network/9606.ENSP00000405289 | Zinc finger protein 778; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ETV1 protein network | https://string-db.org/network/9606.ENSP00000405327 | ETS translocation variant 1; Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'; Belongs to the ETS family |
| ESR1 protein network | https://string-db.org/network/9606.ENSP00000405330 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differenti [...] |
| INPP5D protein network | https://string-db.org/network/9606.ENSP00000405338 | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdI [...] |
| CA10 protein network | https://string-db.org/network/9606.ENSP00000405388 | Carbonic anhydrase-related protein 10; Does not have a catalytic activity; Belongs to the alpha-carbonic anhydrase family |
| PHLDB2 protein network | https://string-db.org/network/9606.ENSP00000405405 | Pleckstrin homology-like domain family B member 2; Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsyn [...] |
| HHATL protein network | https://string-db.org/network/9606.ENSP00000405423 | Protein-cysteine N-palmitoyltransferase HHAT-like protein; Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN; Belongs to the membrane-bound acyltransferase family. HHAT subfamily |
| OXR1 protein network | https://string-db.org/network/9606.ENSP00000405424 | Oxidation resistance protein 1; May be involved in protection from oxidative damage |
| SVOPL protein network | https://string-db.org/network/9606.ENSP00000405482 | Putative transporter SVOPL; SVOP like; Belongs to the major facilitator superfamily |
| PPP1R9A protein network | https://string-db.org/network/9606.ENSP00000405514 | Neurabin-1; Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1- alpha [...] |
| GPI protein network | https://string-db.org/network/9606.ENSP00000405573 | Glucose-6-phosphate isomerase; Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell mo [...] |
| TBL1XR1 protein network | https://string-db.org/network/9606.ENSP00000405574 | F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an [...] |
| CHMP3 protein network | https://string-db.org/network/9606.ENSP00000405575 | Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| CLMP protein network | https://string-db.org/network/9606.ENSP00000405577 | CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development [...] |
| DHX30 protein network | https://string-db.org/network/9606.ENSP00000405620 | Putative ATP-dependent RNA helicase DHX30; Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein [...] |
| CNEP1R1 protein network | https://string-db.org/network/9606.ENSP00000405635 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 |
| NOL7 protein network | https://string-db.org/network/9606.ENSP00000405674 | Nucleolar protein 7 |
| ENSG00000254706 protein network | https://string-db.org/network/9606.ENSP00000405676 | Uncharacterized protein; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein |
| ZNF837 protein network | https://string-db.org/network/9606.ENSP00000405699 | Zinc finger protein 837; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CCDC39 protein network | https://string-db.org/network/9606.ENSP00000405708 | Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby [...] |
| CDC45 protein network | https://string-db.org/network/9606.ENSP00000405726 | Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication |
| ESRP1 protein network | https://string-db.org/network/9606.ENSP00000405738 | Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelia [...] |
| SLC4A8 protein network | https://string-db.org/network/9606.ENSP00000405812 | Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in p [...] |
| RXFP1 protein network | https://string-db.org/network/9606.ENSP00000405841 | Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may a [...] |
| PBX1 protein network | https://string-db.org/network/9606.ENSP00000405890 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator [...] |
| AQP12A protein network | https://string-db.org/network/9606.ENSP00000405899 | Aquaporin-12A; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily |
| TMED7 protein network | https://string-db.org/network/9606.ENSP00000405926 | Transmembrane emp24 domain-containing protein 7; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Appears to play a role in the biosynthesis of secreted car [...] |
| PNCK protein network | https://string-db.org/network/9606.ENSP00000405950 | Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN [...] |
| RASGRF1 protein network | https://string-db.org/network/9606.ENSP00000405963 | Ras-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP; Pleckstrin homology domain containing |
| SUMO2 protein network | https://string-db.org/network/9606.ENSP00000405965 | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to it [...] |
| ACBD4 protein network | https://string-db.org/network/9606.ENSP00000405969 | acyl-CoA binding domain containing 4 |
| LRRD1 protein network | https://string-db.org/network/9606.ENSP00000405987 | Leucine rich repeats and death domain containing 1 |
| IFT140 protein network | https://string-db.org/network/9606.ENSP00000406012 | Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function [...] |
| UNC5C protein network | https://string-db.org/network/9606.ENSP00000406022 | Netrin receptor UNC5C; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in gro [...] |
| SH2D5 protein network | https://string-db.org/network/9606.ENSP00000406026 | SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels |
| EPM2AIP1 protein network | https://string-db.org/network/9606.ENSP00000406027 | EPM2A interacting protein 1 |
| KAT8 protein network | https://string-db.org/network/9606.ENSP00000406037 | Histone acetyltransferase KAT8; Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acet [...] |
| POLD1 protein network | https://string-db.org/network/9606.ENSP00000406046 | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in [...] |
| TSGA13 protein network | https://string-db.org/network/9606.ENSP00000406047 | Testis-specific gene 13 protein; Testis specific 13 |
| HTR3E protein network | https://string-db.org/network/9606.ENSP00000406050 | 5-hydroxytryptamine receptor 3E; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mit [...] |
| TDRD5 protein network | https://string-db.org/network/9606.ENSP00000406052 | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integr [...] |
| WDR20 protein network | https://string-db.org/network/9606.ENSP00000406084 | WD repeat-containing protein 20; Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12. Anchors at the base of the ubiquitin-contacting loop o [...] |
| CTXN2 protein network | https://string-db.org/network/9606.ENSP00000406145 | Cortexin-2; Cortexin 2 |
| PAPSS2 protein network | https://string-db.org/network/9606.ENSP00000406157 | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. T [...] |
| PRMT1 protein network | https://string-db.org/network/9606.ENSP00000406162 | Protein arginine N-methyltransferase 1; Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1 [...] |
| GMNC protein network | https://string-db.org/network/9606.ENSP00000406164 | Geminin coiled-coil domain-containing protein 1; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2- dependent recruitment of CDC45L on [...] |
| TRPV4 protein network | https://string-db.org/network/9606.ENSP00000406191 | Transient receptor potential cation channel subfamily V member 4; Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to h [...] |
| PAQR8 protein network | https://string-db.org/network/9606.ENSP00000406197 | Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similari [...] |
| ZNF160 protein network | https://string-db.org/network/9606.ENSP00000406201 | Zinc finger protein 160; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| EPN1 protein network | https://string-db.org/network/9606.ENSP00000406209 | Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By simi [...] |
| SLC13A5 protein network | https://string-db.org/network/9606.ENSP00000406220 | Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate ra [...] |
| FAT1 protein network | https://string-db.org/network/9606.ENSP00000406229 | Protocadherin Fat 1; Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact; Cadherin related |
| ENPP3 protein network | https://string-db.org/network/9606.ENSP00000406261 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD; CD molecules |
| ZBTB7B protein network | https://string-db.org/network/9606.ENSP00000406286 | Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment [...] |
| TCEA3 protein network | https://string-db.org/network/9606.ENSP00000406293 | Transcription elongation factor A protein 3; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...] |
| ZNF880 protein network | https://string-db.org/network/9606.ENSP00000406318 | Zinc finger protein 880; Zinc fingers C2H2-type |
| COX20 protein network | https://string-db.org/network/9606.ENSP00000406327 | Cytochrome c oxidase protein 20 homolog; Mitochondrial respiratory chain complex assembly factors; Belongs to the COX20 family |
| GPR124 protein network | https://string-db.org/network/9606.ENSP00000406367 | Adhesion G protein-coupled receptor A2; Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprout [...] |
| DNAJC7 protein network | https://string-db.org/network/9606.ENSP00000406463 | DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progestero [...] |
| CDK15 protein network | https://string-db.org/network/9606.ENSP00000406472 | Cyclin-dependent kinase 15; Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'; [...] |
| LILRB5 protein network | https://string-db.org/network/9606.ENSP00000406478 | Leukocyte immunoglobulin-like receptor subfamily B member 5; May act as receptor for class I MHC antigens; CD molecules |
| THSD7A protein network | https://string-db.org/network/9606.ENSP00000406482 | Thrombospondin type-1 domain-containing protein 7A; The soluble form promotes endothelial cell migration and filopodia formationduring angiogenesis via a FAK-dependent mechanism |
| PMS1 protein network | https://string-db.org/network/9606.ENSP00000406490 | PMS1 protein homolog 1; Probably involved in the repair of mismatches in DNA |
| C11orf21 protein network | https://string-db.org/network/9606.ENSP00000406541 | Uncharacterized protein C11orf21; Chromosome 11 open reading frame 21 |
| SLC23A3 protein network | https://string-db.org/network/9606.ENSP00000406546 | Solute carrier family 23 member 3; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily |
| TAF1 protein network | https://string-db.org/network/9606.ENSP00000406549 | Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which [...] |
| CKMT1A protein network | https://string-db.org/network/9606.ENSP00000406577 | Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role [...] |
| ENSG00000279765 protein network | https://string-db.org/network/9606.ENSP00000406581 | cDNA FLJ53879, highly similar to Chromodomain-helicase-DNA-binding protein 2 (EC 3.6.1.-); DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remod [...] |
| C4orf27 protein network | https://string-db.org/network/9606.ENSP00000406598 | Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid sp [...] |
| MOGAT1 protein network | https://string-db.org/network/9606.ENSP00000406674 | 2-acylglycerol O-acyltransferase 1; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestin [...] |
| C5orf67 protein network | https://string-db.org/network/9606.ENSP00000406718 | Uncharacterized protein LOC101928448 |
| GTF2IRD2 protein network | https://string-db.org/network/9606.ENSP00000406723 | General transcription factor II-I repeat domain-containing protein 2A; GTF2I repeat domain containing 2 |
| DCD protein network | https://string-db.org/network/9606.ENSP00000406773 | Dermcidin; DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.fae [...] |
| MUC6 protein network | https://string-db.org/network/9606.ENSP00000406861 | Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an im [...] |
| PAK6 protein network | https://string-db.org/network/9606.ENSP00000406873 | P21 protein (Cdc42/Rac)-activated kinase 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors includin [...] |
| TMEM41A protein network | https://string-db.org/network/9606.ENSP00000406885 | Transmembrane protein 41A; Belongs to the TMEM41 family |
| PHOSPHO1 protein network | https://string-db.org/network/9606.ENSP00000406909 | Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate [...] |
| C4orf26 protein network | https://string-db.org/network/9606.ENSP00000406925 | Odontogenesis associated phosphoprotein; May promote nucleation of hydroxyapatite |
| NT5DC2 protein network | https://string-db.org/network/9606.ENSP00000406933 | 5'-nucleotidase domain containing 2 |
| LAX1 protein network | https://string-db.org/network/9606.ENSP00000406970 | Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and BCR (B-cell antigen receptor)- mediated signaling in B-cells |
| GPR6 protein network | https://string-db.org/network/9606.ENSP00000406986 | G-protein coupled receptor 6; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity [...] |
| FAM86B1 protein network | https://string-db.org/network/9606.ENSP00000407067 | Putative protein N-methyltransferase FAM86B1; Seven-beta-strand methyltransferase motif containing |
| HHLA1 protein network | https://string-db.org/network/9606.ENSP00000407107 | HERV-H LTR-associating 1 |
| NAPEPLD protein network | https://string-db.org/network/9606.ENSP00000407112 | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the g [...] |
| SYBU protein network | https://string-db.org/network/9606.ENSP00000407118 | Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly duri [...] |
| ZNF410 protein network | https://string-db.org/network/9606.ENSP00000407130 | Zinc finger protein 410; Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence; Zinc fingers C2H2-type |
| TNPO2 protein network | https://string-db.org/network/9606.ENSP00000407182 | Transportin-2; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate doc [...] |
| ARSG protein network | https://string-db.org/network/9606.ENSP00000407193 | Arylsulfatase G; Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4- methylumbellif [...] |
| IQCA1 protein network | https://string-db.org/network/9606.ENSP00000407213 | IQ motif containing with AAA domain 1 |
| FAM198A protein network | https://string-db.org/network/9606.ENSP00000407301 | Protein FAM198A; Family with sequence similarity 198 member A; Belongs to the FAM198 family |
| EBNA1BP2 protein network | https://string-db.org/network/9606.ENSP00000407323 | Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA; Belongs to the EBP2 family |
| LMNTD1 protein network | https://string-db.org/network/9606.ENSP00000407353 | Lamin tail domain containing 1 |
| GPX1 protein network | https://string-db.org/network/9606.ENSP00000407375 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family |
| MUC7 protein network | https://string-db.org/network/9606.ENSP00000407422 | Mucin-7; May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili; Mucins |
| UNC45A protein network | https://string-db.org/network/9606.ENSP00000407487 | Protein unc-45 homolog A; Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary fo [...] |
| SPINK8 protein network | https://string-db.org/network/9606.ENSP00000407497 | Serine protease inhibitor Kazal-type 8; Probable serine protease inhibitor; Serine peptidase inhibitors, Kazal type |
| PNPLA6 protein network | https://string-db.org/network/9606.ENSP00000407509 | Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 [...] |
| NUTM2E protein network | https://string-db.org/network/9606.ENSP00000407521 | NUT family member 2E; Belongs to the NUT family |
| ZBTB22 protein network | https://string-db.org/network/9606.ENSP00000407545 | Zinc finger and BTB domain-containing protein 22; May be involved in transcriptional regulation; BTB domain containing |
| CHRNA7 protein network | https://string-db.org/network/9606.ENSP00000407546 | Neuronal acetylcholine receptor subunit alpha-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-con [...] |
| GAS7 protein network | https://string-db.org/network/9606.ENSP00000407552 | Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons; F-BAR domain containing |
| SLC25A44 protein network | https://string-db.org/network/9606.ENSP00000407560 | Solute carrier family 25 member 44 |
| HRAS protein network | https://string-db.org/network/9606.ENSP00000407586 | GTPase HRas; Involved in the activation of Ras protein signal transduction. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family |
| KCNMB2 protein network | https://string-db.org/network/9606.ENSP00000407592 | Potassium large conductance calcium-activated channel, subfamily M, beta member 2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity [...] |
| METTL6 protein network | https://string-db.org/network/9606.ENSP00000407613 | S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser) |
| PRR22 protein network | https://string-db.org/network/9606.ENSP00000407653 | Proline-rich protein 22; Proline rich 22 |
| TNXB protein network | https://string-db.org/network/9606.ENSP00000407685 | Tenascin-X; Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. [...] |
| VWA5A protein network | https://string-db.org/network/9606.ENSP00000407726 | Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is invo [...] |
| ACOXL protein network | https://string-db.org/network/9606.ENSP00000407761 | Acyl-coenzyme A oxidase-like protein; acyl-CoA oxidase like; Belongs to the acyl-CoA oxidase family |
| CCDC122 protein network | https://string-db.org/network/9606.ENSP00000407763 | Coiled-coil domain containing 122 |
| USP46 protein network | https://string-db.org/network/9606.ENSP00000407818 | Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67 (By si [...] |
| CNTN6 protein network | https://string-db.org/network/9606.ENSP00000407822 | Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTC [...] |
| NKX1-1 protein network | https://string-db.org/network/9606.ENSP00000407978 | NK1 transcription factor-related protein 1; NKL subclass homeoboxes and pseudogenes; Belongs to the NK-1 homeobox family |
| VRK2 protein network | https://string-db.org/network/9606.ENSP00000408002 | Serine/threonine-protein kinase VRK2; Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interl [...] |
| SLC9A3R2 protein network | https://string-db.org/network/9606.ENSP00000408005 | Na(+)/H(+) exchange regulatory cofactor NHE-RF2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the acti [...] |
| FBP1 protein network | https://string-db.org/network/9606.ENSP00000408025 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenes [...] |
| METTL11B protein network | https://string-db.org/network/9606.ENSP00000408058 | Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiato [...] |
| WDR26 protein network | https://string-db.org/network/9606.ENSP00000408108 | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G [...] |
| GOLGA6B protein network | https://string-db.org/network/9606.ENSP00000408132 | Golgin A6 family member B; Belongs to the GOLGA6 family |
| HLA-DPB1 protein network | https://string-db.org/network/9606.ENSP00000408146 | HLA class II histocompatibility antigen, DP beta 1 chain; Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surf [...] |
| CT47A9 protein network | https://string-db.org/network/9606.ENSP00000408204 | Cancer/testis antigen family 47, member A9 |
| LPAR4 protein network | https://string-db.org/network/9606.ENSP00000408205 | Lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stim [...] |
| CYTH2 protein network | https://string-db.org/network/9606.ENSP00000408236 | Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP wit [...] |
| PPP1R3E protein network | https://string-db.org/network/9606.ENSP00000408288 | Protein phosphatase 1 regulatory subunit 3E; Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to [...] |
| TRIM32 protein network | https://string-db.org/network/9606.ENSP00000408292 | E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in media [...] |
| RFC5 protein network | https://string-db.org/network/9606.ENSP00000408295 | Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) [...] |
| PRAM1 protein network | https://string-db.org/network/9606.ENSP00000408342 | PML-RARA-regulated adapter molecule 1; May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P |
| CHTF8 protein network | https://string-db.org/network/9606.ENSP00000408367 | Chromosome transmission fidelity protein 8 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear [...] |
| LAMP2 protein network | https://string-db.org/network/9606.ENSP00000408411 | Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and [...] |
| VWA9 protein network | https://string-db.org/network/9606.ENSP00000408429 | Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent proce [...] |
| ENSG00000237847 protein network | https://string-db.org/network/9606.ENSP00000408511 | Family with sequence similarity 231, member A |
| IMPA1 protein network | https://string-db.org/network/9606.ENSP00000408526 | Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological targe [...] |
| C2orf61 protein network | https://string-db.org/network/9606.ENSP00000408527 | Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing [...] |
| LARS2 protein network | https://string-db.org/network/9606.ENSP00000408576 | Probable leucine--tRNA ligase, mitochondrial; leucyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I |
| TMEM132D protein network | https://string-db.org/network/9606.ENSP00000408581 | Transmembrane protein 132D; May serve as a cell-surface marker for oligodendrocyte differentiation; Protein phosphatase 1 regulatory subunits |
| PABPN1L protein network | https://string-db.org/network/9606.ENSP00000408598 | Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA; RNA binding motif containing |
| HDAC9 protein network | https://string-db.org/network/9606.ENSP00000408617 | Histone deacetylase 9; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| PRKCA protein network | https://string-db.org/network/9606.ENSP00000408695 | Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proli [...] |
| NUGGC protein network | https://string-db.org/network/9606.ENSP00000408697 | Nuclear GTPase SLIP-GC; Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells [...] |
| SP8 protein network | https://string-db.org/network/9606.ENSP00000408792 | Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgro [...] |
| CYP21A2 protein network | https://string-db.org/network/9606.ENSP00000408860 | Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids; Cytochrome P450 family 21 |
| DCTN2 protein network | https://string-db.org/network/9606.ENSP00000408910 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring micr [...] |
| KIF5A protein network | https://string-db.org/network/9606.ENSP00000408979 | Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusi [...] |
| IFNL3 protein network | https://string-db.org/network/9606.ENSP00000409000 | Interferon lambda-3; Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a l [...] |
| GDNF protein network | https://string-db.org/network/9606.ENSP00000409007 | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake [...] |
| TBRG1 protein network | https://string-db.org/network/9606.ENSP00000409016 | Transforming growth factor beta regulator 1; Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require eithe [...] |
| ZBTB42 protein network | https://string-db.org/network/9606.ENSP00000409107 | Zinc finger and BTB domain-containing protein 42; Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes; BTB domain contain [...] |
| ANO6 protein network | https://string-db.org/network/9606.ENSP00000409126 | Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling resu [...] |
| WSB2 protein network | https://string-db.org/network/9606.ENSP00000409131 | WD repeat and SOCS box-containing protein 2; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitina [...] |
| PLXNB2 protein network | https://string-db.org/network/9606.ENSP00000409171 | Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosp [...] |
| C10orf55 protein network | https://string-db.org/network/9606.ENSP00000409225 | Uncharacterized protein C10orf55; Chromosome 10 open reading frame 55 |
| TRAPPC13 protein network | https://string-db.org/network/9606.ENSP00000409231 | Belongs to the TRAPPC13 family |
| OTUD4 protein network | https://string-db.org/network/9606.ENSP00000409279 | OTU domain-containing protein 4; Deubiquitinating enzyme that specifically hydrolyzes 'Lys-48'-linked polyubiquitin; OTU domain containing |
| RBM18 protein network | https://string-db.org/network/9606.ENSP00000409315 | Probable RNA-binding protein 18; RNA binding motif containing |
| OR4F29 protein network | https://string-db.org/network/9606.ENSP00000409316 | Olfactory receptor 4F3/4F16/4F29; Odorant receptor; Olfactory receptors, family 4 |
| ZNF230 protein network | https://string-db.org/network/9606.ENSP00000409318 | Zinc finger protein 230; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CISH protein network | https://string-db.org/network/9606.ENSP00000409346 | Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regu [...] |
| CHRM4 protein network | https://string-db.org/network/9606.ENSP00000409378 | Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modu [...] |
| CRACR2A protein network | https://string-db.org/network/9606.ENSP00000409382 | EF-hand calcium-binding domain-containing protein 4B; Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as [...] |
| FAM47E protein network | https://string-db.org/network/9606.ENSP00000409423 | Protein FAM47E; Family with sequence similarity 47 member E |
| ZNF740 protein network | https://string-db.org/network/9606.ENSP00000409463 | Zinc finger protein 740; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LOC388849 protein network | https://string-db.org/network/9606.ENSP00000409542 | Coiled-coil domain-containing protein 188; Uncharacterized protein LOC388849 |
| CLDN4 protein network | https://string-db.org/network/9606.ENSP00000409544 | Claudin-4; Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the k [...] |
| HERPUD1 protein network | https://string-db.org/network/9606.ENSP00000409555 | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degra [...] |
| ARRB1 protein network | https://string-db.org/network/9606.ENSP00000409581 | Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous d [...] |
| ZNF766 protein network | https://string-db.org/network/9606.ENSP00000409652 | Zinc finger protein 766; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SUMO3 protein network | https://string-db.org/network/9606.ENSP00000409666 | Small ubiquitin-like modifier 3 |
| SYNJ1 protein network | https://string-db.org/network/9606.ENSP00000409667 | Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosph [...] |
| TMBIM1 protein network | https://string-db.org/network/9606.ENSP00000409738 | Protein lifeguard 3; Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling; Transmembrane BAX inhibitor motif containing |
| RPP21 protein network | https://string-db.org/network/9606.ENSP00000409799 | Ribonuclease P protein subunit p21; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P prote [...] |
| GAGE12J protein network | https://string-db.org/network/9606.ENSP00000409832 | G antigen 12J |
| CCNB1IP1 protein network | https://string-db.org/network/9606.ENSP00000409896 | E3 ubiquitin-protein ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS [...] |
| USP53 protein network | https://string-db.org/network/9606.ENSP00000409906 | Inactive ubiquitin carboxyl-terminal hydrolase 53; Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier propertie [...] |
| PTGES3L-AARSD1 protein network | https://string-db.org/network/9606.ENSP00000409924 | PTGES3L-AARSD1 readthrough; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) |
| ALS2CR11 protein network | https://string-db.org/network/9606.ENSP00000409937 | C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 |
| VPS52 protein network | https://string-db.org/network/9606.ENSP00000409952 | Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TG [...] |
| CFAP97 protein network | https://string-db.org/network/9606.ENSP00000409964 | Cilia and flagella associated protein 97 |
| FBXO46 protein network | https://string-db.org/network/9606.ENSP00000410007 | F-box only protein 46; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| PHGR1 protein network | https://string-db.org/network/9606.ENSP00000410024 | Proline, histidine and glycine rich 1 |
| SKIDA1 protein network | https://string-db.org/network/9606.ENSP00000410041 | Belongs to the DACH/dachshund family |
| EEF1D protein network | https://string-db.org/network/9606.ENSP00000410059 | Elongation factor 1-delta; Isoform 1: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1- alpha for another round of transfer of aminoacyl-tRNAs [...] |
| VEZT protein network | https://string-db.org/network/9606.ENSP00000410083 | Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. In case of Listeria infection, promotes bacterial internalization by participating in [...] |
| TBC1D26 protein network | https://string-db.org/network/9606.ENSP00000410111 | TBC1 domain family member 26; May act as a GTPase-activating protein for Rab family protein(s); Belongs to the krueppel C2H2-type zinc-finger protein family |
| ABTB2 protein network | https://string-db.org/network/9606.ENSP00000410157 | Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth; Ankyrin repeat domain containing |
| AK9 protein network | https://string-db.org/network/9606.ENSP00000410186 | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate k [...] |
| ZSCAN2 protein network | https://string-db.org/network/9606.ENSP00000410198 | Zinc finger and SCAN domain-containing protein 2; May be involved in transcriptional regulation during the post-meiotic stages of spermatogenesis; SCAN domain containing |
| POC5 protein network | https://string-db.org/network/9606.ENSP00000410216 | Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation; Belongs to the POC5 family |
| SCN5A protein network | https://string-db.org/network/9606.ENSP00000410257 | Sodium channel protein type 5 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the [...] |
| TMEM176B protein network | https://string-db.org/network/9606.ENSP00000410269 | Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity); Membrane spanning 4-domains |
| FGFR2 protein network | https://string-db.org/network/9606.ENSP00000410294 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, [...] |
| PDE1A protein network | https://string-db.org/network/9606.ENSP00000410309 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regu [...] |
| TOMM40 protein network | https://string-db.org/network/9606.ENSP00000410339 | Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria; Belongs to the Tom40 family |
| CMSS1 protein network | https://string-db.org/network/9606.ENSP00000410396 | Protein CMSS1; Cms1 ribosomal small subunit homolog |
| CT47A11 protein network | https://string-db.org/network/9606.ENSP00000410400 | Cancer/testis antigen family 47, member A11 |
| MAP2K4 protein network | https://string-db.org/network/9606.ENSP00000410402 | Dual specificity mitogen-activated protein kinase kinase 4; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component [...] |
| TAF1D protein network | https://string-db.org/network/9606.ENSP00000410409 | TATA box-binding protein-associated factor RNA polymerase I subunit D; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation comple [...] |
| TRIM26 protein network | https://string-db.org/network/9606.ENSP00000410446 | Tripartite motif-containing protein 26; E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA- encoded pattern-recognition receptors [...] |
| STMN1 protein network | https://string-db.org/network/9606.ENSP00000410452 | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 [...] |
| ZNF90 protein network | https://string-db.org/network/9606.ENSP00000410466 | Zinc finger protein 90; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FAHD2B protein network | https://string-db.org/network/9606.ENSP00000410470 | Fumarylacetoacetate hydrolase domain-containing protein 2B; May have hydrolase activity |
| LTB protein network | https://string-db.org/network/9606.ENSP00000410481 | Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the [...] |
| RNF223 protein network | https://string-db.org/network/9606.ENSP00000410533 | Ring finger protein 223 |
| ZNF814 protein network | https://string-db.org/network/9606.ENSP00000410545 | Zinc finger protein 814; Zinc fingers C2H2-type |
| CDK3 protein network | https://string-db.org/network/9606.ENSP00000410561 | Cyclin-dependent kinase 3; Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0- G1 and G1-S cell cycle transitions. Interacts wi [...] |
| CELF4 protein network | https://string-db.org/network/9606.ENSP00000410584 | CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissu [...] |
| FAM131B protein network | https://string-db.org/network/9606.ENSP00000410603 | Protein FAM131B; Family with sequence similarity 131 member B; Belongs to the FAM131 family |
| AFAP1 protein network | https://string-db.org/network/9606.ENSP00000410689 | Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipod [...] |
| SFRP4 protein network | https://string-db.org/network/9606.ENSP00000410715 | Secreted frizzled-related protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell gr [...] |
| GABRG2 protein network | https://string-db.org/network/9606.ENSP00000410732 | Gamma-aminobutyric acid receptor subunit gamma-2; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine r [...] |
| ZNF562 protein network | https://string-db.org/network/9606.ENSP00000410734 | Zinc finger protein 562; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LSM5 protein network | https://string-db.org/network/9606.ENSP00000410758 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating formation of the spliceosomal U4/U6 duplex formatio [...] |
| ATXN7L1 protein network | https://string-db.org/network/9606.ENSP00000410759 | Ataxin-7-like protein 1; Ataxin 7 like 1 |
| ENSG00000272752 protein network | https://string-db.org/network/9606.ENSP00000410764 | annotation not available |
| FAM135A protein network | https://string-db.org/network/9606.ENSP00000410768 | Protein FAM135A; Family with sequence similarity 135 member A; Belongs to the FAM135 family |
| CNBP protein network | https://string-db.org/network/9606.ENSP00000410769 | Cellular nucleic acid-binding protein; Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression; Ring finger proteins |
| PNPLA8 protein network | https://string-db.org/network/9606.ENSP00000410804 | Calcium-independent phospholipase A2-gamma; Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. [...] |
| FIGNL1 protein network | https://string-db.org/network/9606.ENSP00000410811 | Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dep [...] |
| ENSG00000244255 protein network | https://string-db.org/network/9606.ENSP00000410815 | Complement factor B; Uncharacterized protein; cDNA FLJ55673, highly similar to Complement factor B ; Belongs to the peptidase S1 family |
| MAD2L1BP protein network | https://string-db.org/network/9606.ENSP00000410818 | MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 comple [...] |
| GBE1 protein network | https://string-db.org/network/9606.ENSP00000410833 | 1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule (Probable); Be [...] |
| TMEM132C protein network | https://string-db.org/network/9606.ENSP00000410852 | Transmembrane protein 132C; Protein phosphatase 1 regulatory subunits |
| NHLRC4 protein network | https://string-db.org/network/9606.ENSP00000410858 | NHL-repeat-containing protein 4; NHL repeat containing 4 |
| RUNDC3A protein network | https://string-db.org/network/9606.ENSP00000410862 | RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells; Belongs to the RUNDC3 family |
| ZNF783 protein network | https://string-db.org/network/9606.ENSP00000410890 | Protein ZNF783; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MUSTN1 protein network | https://string-db.org/network/9606.ENSP00000410910 | Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system |
| LMLN protein network | https://string-db.org/network/9606.ENSP00000410926 | Leishmanolysin-like peptidase; Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration |
| TSPYL4 protein network | https://string-db.org/network/9606.ENSP00000410943 | Testis-specific Y-encoded-like protein 4; TSPY like 4 |
| ERLIN1 protein network | https://string-db.org/network/9606.ENSP00000410964 | Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of [...] |
| XG protein network | https://string-db.org/network/9606.ENSP00000411004 | Glycoprotein Xg; Pseudoautosomal region 1; Belongs to the CD99 family |
| DNTTIP2 protein network | https://string-db.org/network/9606.ENSP00000411010 | Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein |
| NSMAF protein network | https://string-db.org/network/9606.ENSP00000411012 | Protein FAN; Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide productio [...] |
| ZNF284 protein network | https://string-db.org/network/9606.ENSP00000411032 | Zinc finger protein 284; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LCE6A protein network | https://string-db.org/network/9606.ENSP00000411070 | Late cornified envelope protein 6A; Precursors of the cornified envelope of the stratum corneum |
| BCL7B protein network | https://string-db.org/network/9606.ENSP00000411073 | B-cell CLL/lymphoma 7 protein family member B; Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 [...] |
| ZNF799 protein network | https://string-db.org/network/9606.ENSP00000411084 | Zinc finger protein 799; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ABCA13 protein network | https://string-db.org/network/9606.ENSP00000411096 | ATP binding cassette subfamily A member 13 |
| TLK1 protein network | https://string-db.org/network/9606.ENSP00000411099 | Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle che [...] |
| BEGAIN protein network | https://string-db.org/network/9606.ENSP00000411124 | Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD) |
| ZNF619 protein network | https://string-db.org/network/9606.ENSP00000411132 | Zinc finger protein 619; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NPIPB15 protein network | https://string-db.org/network/9606.ENSP00000411140 | Nuclear pore complex interacting protein family member B15 |
| FEZF1 protein network | https://string-db.org/network/9606.ENSP00000411145 | Fez family zinc finger protein 1; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of [...] |
| ITPKB protein network | https://string-db.org/network/9606.ENSP00000411152 | Inositol-trisphosphate 3-kinase B |
| TBC1D9 protein network | https://string-db.org/network/9606.ENSP00000411197 | TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s); EF-hand domain containing |
| NBR1 protein network | https://string-db.org/network/9606.ENSP00000411250 | Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets; Zinc fingers ZZ-type |
| TBCCD1 protein network | https://string-db.org/network/9606.ENSP00000411253 | TBCC domain-containing protein 1; Plays a role in the regulation of centrosome and Golgi apparatus positioning, with consequences on cell shape and cell migration |
| BEND3 protein network | https://string-db.org/network/9606.ENSP00000411268 | BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoyla [...] |
| PTPRC protein network | https://string-db.org/network/9606.ENSP00000411355 | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation [...] |
| FAM200A protein network | https://string-db.org/network/9606.ENSP00000411372 | Protein FAM200A; Family with sequence similarity 200 member A; Belongs to the FAM200 family |
| MARK3 protein network | https://string-db.org/network/9606.ENSP00000411397 | MAP/microtubule affinity-regulating kinase 3; Involved in the specific phosphorylation of microtubule- associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C on 'Ser-216'. Regulates lo [...] |
| ZNF598 protein network | https://string-db.org/network/9606.ENSP00000411409 | E3 ubiquitin-protein ligase ZNF598; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translat [...] |
| RAB3GAP1 protein network | https://string-db.org/network/9606.ENSP00000411418 | Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins [...] |
| PATE4 protein network | https://string-db.org/network/9606.ENSP00000411439 | Prostate and testis expressed protein 4; May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility; LY6/PLAUR domain containing |
| ABCF3 protein network | https://string-db.org/network/9606.ENSP00000411471 | ATP-binding cassette sub-family F member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B; ATP binding cassette subfamily F |
| FAM153A protein network | https://string-db.org/network/9606.ENSP00000411506 | Protein FAM153A; Family with sequence similarity 153 member A; Belongs to the FAM153 family |
| GJC1 protein network | https://string-db.org/network/9606.ENSP00000411528 | Gap junction gamma-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| TOP2A protein network | https://string-db.org/network/9606.ENSP00000411532 | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosi [...] |
| DHRS12 protein network | https://string-db.org/network/9606.ENSP00000411565 | Dehydrogenase/reductase SDR family member 12; Putative oxidoreductase; Short chain dehydrogenase/reductase superfamily |
| MSANTD1 protein network | https://string-db.org/network/9606.ENSP00000411584 | Myb/SANT-like DNA-binding domain-containing protein 1; Myb/SANT DNA binding domain containing 1 |
| GLRA1 protein network | https://string-db.org/network/9606.ENSP00000411593 | Glycine receptor subunit alpha-1; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and bet [...] |
| AOC1 protein network | https://string-db.org/network/9606.ENSP00000411613 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune r [...] |
| ATP6V0E2 protein network | https://string-db.org/network/9606.ENSP00000411672 | ATPase H+ transporting V0 subunit e2; V-type ATPases |
| COLEC11 protein network | https://string-db.org/network/9606.ENSP00000411770 | Collectin-11; Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylga [...] |
| GPR35 protein network | https://string-db.org/network/9606.ENSP00000411788 | G-protein coupled receptor 35; Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calc [...] |
| CSGALNACT1 protein network | https://string-db.org/network/9606.ENSP00000411816 | Chondroitin sulfate N-acetylgalactosaminyltransferase 1; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of [...] |
| ALDH3A1 protein network | https://string-db.org/network/9606.ENSP00000411821 | Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, [...] |
| ISY1-RAB43 protein network | https://string-db.org/network/9606.ENSP00000411822 | Component of the spliceosome C complex required for the selective processing of microRNAs during embryonic stem cell differentiation (By similarity). Required for the biogenesis of all miRNAs fro [...] |
| PDCD6IP protein network | https://string-db.org/network/9606.ENSP00000411825 | Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junc [...] |
| GPR137 protein network | https://string-db.org/network/9606.ENSP00000411827 | Integral membrane protein GPR137; G protein-coupled receptor 137; Belongs to the GPR137 family |
| KIF21B protein network | https://string-db.org/network/9606.ENSP00000411831 | Kinesin-like protein KIF21B; Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neur [...] |
| MARCH8 protein network | https://string-db.org/network/9606.ENSP00000411848 | E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocy [...] |
| C10orf131 protein network | https://string-db.org/network/9606.ENSP00000411850 | Protein CC2D2B; Chromosome 10 open reading frame 131 |
| EPGN protein network | https://string-db.org/network/9606.ENSP00000411898 | Epigen; Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases |
| CT47A10 protein network | https://string-db.org/network/9606.ENSP00000411909 | Cancer/testis antigen family 47, member A10 |
| LMOD2 protein network | https://string-db.org/network/9606.ENSP00000411932 | Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization. Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcome [...] |
| IFNA17 protein network | https://string-db.org/network/9606.ENSP00000411940 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfer [...] |
| SAPCD1 protein network | https://string-db.org/network/9606.ENSP00000411948 | Suppressor APC domain containing 1 |
| PRR13 protein network | https://string-db.org/network/9606.ENSP00000412064 | Proline-rich protein 13; Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane- induced apoptosis |
| MRVI1 protein network | https://string-db.org/network/9606.ENSP00000412130 | Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular st [...] |
| CCDC121 protein network | https://string-db.org/network/9606.ENSP00000412150 | Coiled-coil domain containing 121 |
| DGKZ protein network | https://string-db.org/network/9606.ENSP00000412178 | Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. I [...] |
| PGAM4 protein network | https://string-db.org/network/9606.ENSP00000412189 | Phosphoglycerate mutase family member 4; Bisphosphoglycerate phosphatases |
| IL5RA protein network | https://string-db.org/network/9606.ENSP00000412209 | Interleukin-5 receptor subunit alpha; This is the receptor for interleukin-5. The alpha chain binds to IL5; Belongs to the type I cytokine receptor family. Type 5 subfamily |
| C4orf45 protein network | https://string-db.org/network/9606.ENSP00000412215 | Uncharacterized protein C4orf45; Chromosome 4 open reading frame 45 |
| IL10 protein network | https://string-db.org/network/9606.ENSP00000412237 | Interleukin-10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells; Belongs to the IL-10 fami [...] |
| DEPDC1 protein network | https://string-db.org/network/9606.ENSP00000412292 | DEP domain-containing protein 1A; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by [...] |
| MBD3 protein network | https://string-db.org/network/9606.ENSP00000412302 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing meth [...] |
| PPP2R5C protein network | https://string-db.org/network/9606.ENSP00000412324 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...] |
| ARPP21 protein network | https://string-db.org/network/9606.ENSP00000412326 | cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons |
| SIGLEC11 protein network | https://string-db.org/network/9606.ENSP00000412361 | Sialic acid-binding Ig-like lectin 11; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid reco [...] |
| ZNF438 protein network | https://string-db.org/network/9606.ENSP00000412363 | Zinc finger protein 438; Isoform 1 acts as a transcriptional repressor; Zinc fingers C2H2-type |
| CDKL2 protein network | https://string-db.org/network/9606.ENSP00000412365 | Cyclin-dependent kinase-like 2; Cyclin dependent kinase like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily |
| C9orf172 protein network | https://string-db.org/network/9606.ENSP00000412388 | Uncharacterized protein C9orf172; Chromosome 9 open reading frame 172 |
| ENSG00000248993 protein network | https://string-db.org/network/9606.ENSP00000412457 | HLA class II histocompatibility antigen, DM beta chain |
| ARHGAP22 protein network | https://string-db.org/network/9606.ENSP00000412461 | Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a [...] |
| TMEM169 protein network | https://string-db.org/network/9606.ENSP00000412524 | Transmembrane protein 169 |
| SNRPB protein network | https://string-db.org/network/9606.ENSP00000412566 | Small nuclear ribonucleoprotein-associated proteins B and B; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome [...] |
| GABRR1 protein network | https://string-db.org/network/9606.ENSP00000412673 | Gamma-aminobutyric acid receptor subunit rho-1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...] |
| MMS19 protein network | https://string-db.org/network/9606.ENSP00000412698 | MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur [...] |
| FAM115C protein network | https://string-db.org/network/9606.ENSP00000412724 | TRPM8 channel-associated factor 2; Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate c [...] |
| OSBPL9 protein network | https://string-db.org/network/9606.ENSP00000412733 | Oxysterol-binding protein-related protein 9; Pleckstrin homology domain containing; Belongs to the OSBP family |
| OR4A47 protein network | https://string-db.org/network/9606.ENSP00000412752 | Olfactory receptor 4A47; Odorant receptor; Olfactory receptors, family 4 |
| MALRD1 protein network | https://string-db.org/network/9606.ENSP00000412763 | MAM and LDL-receptor class A domain-containing protein 1; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis |
| IKZF2 protein network | https://string-db.org/network/9606.ENSP00000412869 | Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin; Zinc fingers C2H2-type |
| CAMTA2 protein network | https://string-db.org/network/9606.ENSP00000412886 | Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor; Belongs to the CAMTA family |
| RPP14 protein network | https://string-db.org/network/9606.ENSP00000412894 | Ribonuclease P protein subunit p14; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends |
| IFNA4 protein network | https://string-db.org/network/9606.ENSP00000412897 | Interferon alpha-4; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Belongs t [...] |
| URM1 protein network | https://string-db.org/network/9606.ENSP00000412922 | Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in [...] |
| HLA-G protein network | https://string-db.org/network/9606.ENSP00000412927 | HLA class I histocompatibility antigen, alpha chain G; Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protecti [...] |
| FREM1 protein network | https://string-db.org/network/9606.ENSP00000412940 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belo [...] |
| BIRC8 protein network | https://string-db.org/network/9606.ENSP00000412957 | Baculoviral IAP repeat-containing protein 8; Protects against apoptosis mediated by BAX; Belongs to the IAP family |
| ZNF805 protein network | https://string-db.org/network/9606.ENSP00000412999 | Zinc finger protein 805; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| AGBL1 protein network | https://string-db.org/network/9606.ENSP00000413001 | Cytosolic carboxypeptidase 4; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...] |
| CCDC28B protein network | https://string-db.org/network/9606.ENSP00000413017 | Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex [...] |
| C7orf25 protein network | https://string-db.org/network/9606.ENSP00000413029 | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family |
| RBFOX2 protein network | https://string-db.org/network/9606.ENSP00000413035 | RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulate [...] |
| SLC25A48 protein network | https://string-db.org/network/9606.ENSP00000413049 | Solute carrier family 25 member 48 |
| NAT8L protein network | https://string-db.org/network/9606.ENSP00000413064 | N-acetylaspartate synthetase; Plays a role in the regulation of lipogenesis by producing N-acetylaspartate acid (NAA), a brain-specific metabolite. NAA occurs in high concentration in brain and i [...] |
| ZNF445 protein network | https://string-db.org/network/9606.ENSP00000413073 | Zinc finger protein 445; May be involved in transcriptional regulation; SCAN domain containing |
| MICA protein network | https://string-db.org/network/9606.ENSP00000413079 | MHC class I polypeptide-related sequence A; Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/N [...] |
| SCAF8 protein network | https://string-db.org/network/9606.ENSP00000413098 | Protein SCAF8; May play a role in mRNA processing; RNA binding motif containing |
| C16orf91 protein network | https://string-db.org/network/9606.ENSP00000413100 | Protein CCSMST1; Chromosome 16 open reading frame 91 |
| C1orf226 protein network | https://string-db.org/network/9606.ENSP00000413150 | Uncharacterized protein C1orf226; Chromosome 1 open reading frame 226 |
| FKBP7 protein network | https://string-db.org/network/9606.ENSP00000413152 | PPIases accelerate the folding of proteins during protein synthesis |
| RAB34 protein network | https://string-db.org/network/9606.ENSP00000413156 | Ras-related protein Rab-34; Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region (By similarity). Plays a role in the maturation of phagosomes that engulf patho [...] |
| TMEM130 protein network | https://string-db.org/network/9606.ENSP00000413163 | Transmembrane protein 130 |
| FAM160A1 protein network | https://string-db.org/network/9606.ENSP00000413196 | Protein FAM160A1; Family with sequence similarity 160 member A1; Belongs to the UPF0518 family |
| FAM213B protein network | https://string-db.org/network/9606.ENSP00000413218 | Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostagla [...] |
| C3orf55 protein network | https://string-db.org/network/9606.ENSP00000413228 | Putative uncharacterized protein PQLC2L; Chromosome 3 open reading frame 55 |
| PIGZ protein network | https://string-db.org/network/9606.ENSP00000413405 | GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The [...] |
| ZNF724P protein network | https://string-db.org/network/9606.ENSP00000413411 | Zinc finger protein 724; May be involved in transcriptional regulation |
| ZFHX2 protein network | https://string-db.org/network/9606.ENSP00000413418 | Zinc finger homeobox protein 2; May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes |
| RPL10 protein network | https://string-db.org/network/9606.ENSP00000413436 | 60S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development |
| KIAA1324L protein network | https://string-db.org/network/9606.ENSP00000413445 | UPF0577 protein KIAA1324-like; KIAA1324 like; Belongs to the UPF0577 family |
| KRT3 protein network | https://string-db.org/network/9606.ENSP00000413479 | Keratin, type II cytoskeletal 3; Keratins, type II |
| FGF12 protein network | https://string-db.org/network/9606.ENSP00000413496 | Fibroblast growth factor 12; Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by e [...] |
| HID1 protein network | https://string-db.org/network/9606.ENSP00000413520 | Protein HID1; May play an important role in the development of cancers in a broad range of tissues |
| APRG1 protein network | https://string-db.org/network/9606.ENSP00000413537 | AP20 region protein 1; Chromosome 3 open reading frame 35 |
| NLE1 protein network | https://string-db.org/network/9606.ENSP00000413572 | Notchless protein homolog 1; Plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Not [...] |
| CROT protein network | https://string-db.org/network/9606.ENSP00000413575 | Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxi [...] |
| RFESD protein network | https://string-db.org/network/9606.ENSP00000413592 | Rieske domain-containing protein; Rieske Fe-S domain containing |
| STXBP2 protein network | https://string-db.org/network/9606.ENSP00000413606 | Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- et [...] |
| FNBP1 protein network | https://string-db.org/network/9606.ENSP00000413625 | Formin-binding protein 1; May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the [...] |
| MCMDC2 protein network | https://string-db.org/network/9606.ENSP00000413632 | Minichromosome maintenance domain-containing protein 2; Plays an important role in meiotic recombination and associated DNA double-strand break repair; MCM family |
| ZNF492 protein network | https://string-db.org/network/9606.ENSP00000413660 | Zinc finger protein 492; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TOM1 protein network | https://string-db.org/network/9606.ENSP00000413697 | Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family |
| LRRC15 protein network | https://string-db.org/network/9606.ENSP00000413707 | Leucine-rich repeat-containing protein 15; Leucine rich repeat containing 15 |
| CDKN1C protein network | https://string-db.org/network/9606.ENSP00000413720 | Cyclin-dependent kinase inhibitor 1C; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cy [...] |
| C12orf71 protein network | https://string-db.org/network/9606.ENSP00000413728 | Uncharacterized protein C12orf71; Chromosome 12 open reading frame 71 |
| SIGLEC9 protein network | https://string-db.org/network/9606.ENSP00000413861 | Sialic acid-binding Ig-like lectin 9; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sial [...] |
| FAM25BP protein network | https://string-db.org/network/9606.ENSP00000413896 | Family with sequence similarity 25 member B, pseudogene |
| BCS1L protein network | https://string-db.org/network/9606.ENSP00000413908 | Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, re [...] |
| RCOR3 protein network | https://string-db.org/network/9606.ENSP00000413929 | REST corepressor 3; May act as a component of a corepressor complex that represses transcription; Belongs to the CoREST family |
| INPP5K protein network | https://string-db.org/network/9606.ENSP00000413937 | Inositol polyphosphate 5-phosphatase K; Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphati [...] |
| GDPD2 protein network | https://string-db.org/network/9606.ENSP00000414019 | Glycerophosphoinositol inositolphosphodiesterase GDPD2; Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for othe [...] |
| PERM1 protein network | https://string-db.org/network/9606.ENSP00000414022 | PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contr [...] |
| PRR26 protein network | https://string-db.org/network/9606.ENSP00000414034 | Proline-rich protein 26; Proline rich 26 |
| NRBP2 protein network | https://string-db.org/network/9606.ENSP00000414055 | Nuclear receptor-binding protein 2; May regulate apoptosis of neural progenitor cells during their differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family |
| ACN9 protein network | https://string-db.org/network/9606.ENSP00000414066 | Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) [...] |
| ENSG00000255835 protein network | https://string-db.org/network/9606.ENSP00000414068 | Uncharacterized protein |
| HJURP protein network | https://string-db.org/network/9606.ENSP00000414109 | Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chape [...] |
| SPG20 protein network | https://string-db.org/network/9606.ENSP00000414147 | Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis |
| ERG protein network | https://string-db.org/network/9606.ENSP00000414150 | Transcriptional regulator ERG; Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of [...] |
| PPP6R1 protein network | https://string-db.org/network/9606.ENSP00000414202 | Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphor [...] |
| HSBP1L1 protein network | https://string-db.org/network/9606.ENSP00000414236 | Heat shock factor binding protein 1 like 1; Belongs to the HSBP1 family |
| INTS2 protein network | https://string-db.org/network/9606.ENSP00000414237 | Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| CT47A2 protein network | https://string-db.org/network/9606.ENSP00000414253 | Cancer/testis antigen family 47, member A2 |
| MST1 protein network | https://string-db.org/network/9606.ENSP00000414287 | Hepatocyte growth factor-like protein; Macrophage stimulating 1 |
| SRSF12 protein network | https://string-db.org/network/9606.ENSP00000414302 | Serine/arginine-rich splicing factor 12; Splicing factor that seems to antagonize SR proteins in pre-mRNA splicing regulation; RNA binding motif containing |
| BDNF protein network | https://string-db.org/network/9606.ENSP00000414303 | Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in ax [...] |
| RPS24 protein network | https://string-db.org/network/9606.ENSP00000414321 | 40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS24 family |
| RIMKLA protein network | https://string-db.org/network/9606.ENSP00000414330 | N-acetylaspartylglutamate synthase A; Catalyzes the synthesis of N-acetyl-L-aspartyl-L- glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate; Belongs to the RimK family |
| MUC20 protein network | https://string-db.org/network/9606.ENSP00000414350 | Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS path [...] |
| PSMA1 protein network | https://string-db.org/network/9606.ENSP00000414359 | Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles w [...] |
| EFNA4 protein network | https://string-db.org/network/9606.ENSP00000414378 | Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial [...] |
| C11orf70 protein network | https://string-db.org/network/9606.ENSP00000414390 | Uncharacterized protein C11orf70; Chromosome 11 open reading frame 70 |
| USP17L13 protein network | https://string-db.org/network/9606.ENSP00000414392 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 13; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| DNAJB11 protein network | https://string-db.org/network/9606.ENSP00000414398 | DnaJ homolog subfamily B member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates [...] |
| FAM177B protein network | https://string-db.org/network/9606.ENSP00000414451 | Protein FAM177B; Family with sequence similarity 177 member B |
| CT47A12 protein network | https://string-db.org/network/9606.ENSP00000414509 | Cancer/testis antigen family 47, member A12 |
| SS18 protein network | https://string-db.org/network/9606.ENSP00000414516 | Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function [...] |
| MAMLD1 protein network | https://string-db.org/network/9606.ENSP00000414517 | Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ; Belong [...] |
| ABHD4 protein network | https://string-db.org/network/9606.ENSP00000414558 | Protein ABHD4; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydroly [...] |
| EFCC1 protein network | https://string-db.org/network/9606.ENSP00000414597 | EF-hand and coiled-coil domain containing 1 |
| PRPSAP1 protein network | https://string-db.org/network/9606.ENSP00000414624 | Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5- phosphoribose 1-diphosphate synthesis |
| LRRC34 protein network | https://string-db.org/network/9606.ENSP00000414635 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression o [...] |
| OSR2 protein network | https://string-db.org/network/9606.ENSP00000414657 | Protein odd-skipped-related 2; Odd-skipped related transciption factor 2; Zinc fingers C2H2-type |
| LMOD3 protein network | https://string-db.org/network/9606.ENSP00000414670 | Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization; Belongs to the tropomodulin family |
| WBP1L protein network | https://string-db.org/network/9606.ENSP00000414721 | WW domain binding protein 1 like; WBP1/VOPP1 family |
| TMEM64 protein network | https://string-db.org/network/9606.ENSP00000414786 | Transmembrane protein 64; Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which [...] |
| ELP2 protein network | https://string-db.org/network/9606.ENSP00000414851 | Elongator complex protein 2; Regulates the ligand-dependent activation of STAT3; Belongs to the WD repeat ELP2 family |
| SPARCL1 protein network | https://string-db.org/network/9606.ENSP00000414856 | SPARC-like protein 1; SPARC family |
| HYLS1 protein network | https://string-db.org/network/9606.ENSP00000414884 | Hydrolethalus syndrome protein 1; Plays a role in ciliogenesis |
| KCNIP1 protein network | https://string-db.org/network/9606.ENSP00000414886 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing |
| ZNF879 protein network | https://string-db.org/network/9606.ENSP00000414887 | Zinc finger protein 879; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GVQW1 protein network | https://string-db.org/network/9606.ENSP00000414891 | Protein GVQW1; GVQW motif containing 1 |
| CTSO protein network | https://string-db.org/network/9606.ENSP00000414904 | Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover; Belongs to the peptidase C1 family |
| DCTN4 protein network | https://string-db.org/network/9606.ENSP00000414906 | Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles [...] |
| C1orf167 protein network | https://string-db.org/network/9606.ENSP00000414909 | Uncharacterized protein C1orf167; Chromosome 1 open reading frame 167 |
| SPATA24 protein network | https://string-db.org/network/9606.ENSP00000414920 | Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box- containing promoters and with GMNN and [...] |
| PTBP3 protein network | https://string-db.org/network/9606.ENSP00000414921 | Polypyrimidine tract-binding protein 3; RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migra [...] |
| USP41 protein network | https://string-db.org/network/9606.ENSP00000414922 | Putative ubiquitin carboxyl-terminal hydrolase 41; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as we [...] |
| CCDC107 protein network | https://string-db.org/network/9606.ENSP00000414964 | Coiled-coil domain containing 107 |
| KLC1 protein network | https://string-db.org/network/9606.ENSP00000414982 | Kinesin light chain 1; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chai [...] |
| SLC30A8 protein network | https://string-db.org/network/9606.ENSP00000415011 | Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin ma [...] |
| PRRT4 protein network | https://string-db.org/network/9606.ENSP00000415026 | Proline rich transmembrane protein 4 |
| C16orf96 protein network | https://string-db.org/network/9606.ENSP00000415027 | Uncharacterized protein C16orf96; Chromosome 16 open reading frame 96 |
| TMEM171 protein network | https://string-db.org/network/9606.ENSP00000415030 | Transmembrane protein 171 |
| NBEAL2 protein network | https://string-db.org/network/9606.ENSP00000415034 | Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogen [...] |
| GSDMB protein network | https://string-db.org/network/9606.ENSP00000415049 | Gasdermin-B; The N-terminal moiety promotes pyroptosis. May be acting by homooligomerizing within the membrane and forming pores. The physiological relevance of this observation is unknown (Proba [...] |
| EXD1 protein network | https://string-db.org/network/9606.ENSP00000415056 | piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates [...] |
| ENSG00000270011 protein network | https://string-db.org/network/9606.ENSP00000415070 | ZNF559-ZNF177 readthrough; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CACTIN protein network | https://string-db.org/network/9606.ENSP00000415078 | Cactin; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon- regulatory factor (IRF) signaling pathways. Contributes to the regul [...] |
| MYO7B protein network | https://string-db.org/network/9606.ENSP00000415090 | Unconventional myosin-VIIb; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relati [...] |
| KBTBD4 protein network | https://string-db.org/network/9606.ENSP00000415106 | Kelch repeat and BTB domain containing 4 |
| METTL21A protein network | https://string-db.org/network/9606.ENSP00000415115 | Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo t [...] |
| TICAM2 protein network | https://string-db.org/network/9606.ENSP00000415139 | TIR domain-containing adapter molecule 2; Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges [...] |
| CBFB protein network | https://string-db.org/network/9606.ENSP00000415151 | Core-binding factor subunit beta; CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhan [...] |
| ENSG00000249590 protein network | https://string-db.org/network/9606.ENSP00000415178 | Uncharacterized protein |
| PIGG protein network | https://string-db.org/network/9606.ENSP00000415203 | GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second manno [...] |
| NPIPB7 protein network | https://string-db.org/network/9606.ENSP00000415207 | Nuclear pore complex interacting protein family member B7 |
| SKIL protein network | https://string-db.org/network/9606.ENSP00000415243 | Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals; Belongs to the SKI family |
| ICAM2 protein network | https://string-db.org/network/9606.ENSP00000415283 | Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA- [...] |
| FAM221B protein network | https://string-db.org/network/9606.ENSP00000415299 | Protein FAM221B; Family with sequence similarity 221 member B; Belongs to the FAM221 family |
| SESTD1 protein network | https://string-db.org/network/9606.ENSP00000415332 | SEC14 domain and spectrin repeat-containing protein 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5 [...] |
| GTSE1 protein network | https://string-db.org/network/9606.ENSP00000415430 | G2 and S phase-expressed protein 1; May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpressio [...] |
| INTS12 protein network | https://string-db.org/network/9606.ENSP00000415433 | Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Inte [...] |
| USP40 protein network | https://string-db.org/network/9606.ENSP00000415434 | Ubiquitin carboxyl-terminal hydrolase 40; May be catalytically inactive; Belongs to the peptidase C19 family |
| KANSL2 protein network | https://string-db.org/network/9606.ENSP00000415436 | KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulatio [...] |
| GCNT1 protein network | https://string-db.org/network/9606.ENSP00000415454 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-gl [...] |
| PHYHIP protein network | https://string-db.org/network/9606.ENSP00000415491 | Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system |
| C6orf10 protein network | https://string-db.org/network/9606.ENSP00000415517 | Uncharacterized protein C6orf10; Chromosome 6 open reading frame 10 |
| CCDC81 protein network | https://string-db.org/network/9606.ENSP00000415528 | Coiled-coil domain containing 81 |
| POLR2H protein network | https://string-db.org/network/9606.ENSP00000415536 | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...] |
| DCAF11 protein network | https://string-db.org/network/9606.ENSP00000415556 | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| CTCFL protein network | https://string-db.org/network/9606.ENSP00000415579 | Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigen [...] |
| IQCF3 protein network | https://string-db.org/network/9606.ENSP00000415609 | IQ motif containing F3 |
| C17orf105 protein network | https://string-db.org/network/9606.ENSP00000415662 | Uncharacterized protein C17orf105; Chromosome 17 open reading frame 105 |
| ITIH3 protein network | https://string-db.org/network/9606.ENSP00000415769 | Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in [...] |
| ZNF732 protein network | https://string-db.org/network/9606.ENSP00000415774 | Zinc finger protein 732; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SERPINE2 protein network | https://string-db.org/network/9606.ENSP00000415786 | Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin; Belongs to the serpin family |
| ATXN1L protein network | https://string-db.org/network/9606.ENSP00000415822 | Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, alon [...] |
| IGFL1 protein network | https://string-db.org/network/9606.ENSP00000415823 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor |
| ZNF276 protein network | https://string-db.org/network/9606.ENSP00000415836 | Zinc finger protein 276; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ENSG00000250644 protein network | https://string-db.org/network/9606.ENSP00000415840 | Uncharacterized protein |
| PUS7L protein network | https://string-db.org/network/9606.ENSP00000415899 | Pseudouridylate synthase that catalyzes pseudouridylation of RNAs |
| IL31RA protein network | https://string-db.org/network/9606.ENSP00000415900 | Interleukin-31 receptor subunit alpha; Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediate [...] |
| C4B protein network | https://string-db.org/network/9606.ENSP00000415941 | Complement C4-B; Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune co [...] |
| STRBP protein network | https://string-db.org/network/9606.ENSP00000415968 | Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently [...] |
| SLC48A1 protein network | https://string-db.org/network/9606.ENSP00000415998 | Heme transporter HRG1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment; Solute carriers |
| SLC35A2 protein network | https://string-db.org/network/9606.ENSP00000416002 | UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function; Belongs to the nucleotide-sugar transporter family. SLC35A subfa [...] |
| MICAL3 protein network | https://string-db.org/network/9606.ENSP00000416015 | [F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in [...] |
| PROB1 protein network | https://string-db.org/network/9606.ENSP00000416033 | Proline rich basic protein 1 |
| KIAA1549 protein network | https://string-db.org/network/9606.ENSP00000416040 | Belongs to the UPF0606 family |
| TM2D2 protein network | https://string-db.org/network/9606.ENSP00000416050 | TM2 domain containing 2 |
| SERPINA1 protein network | https://string-db.org/network/9606.ENSP00000416066 | Alpha-1-antitrypsin; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and p [...] |
| GOLGA2 protein network | https://string-db.org/network/9606.ENSP00000416097 | Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether th [...] |
| ARHGEF38 protein network | https://string-db.org/network/9606.ENSP00000416125 | Rho guanine nucleotide exchange factor 38; May act as a guanine-nucleotide releasing factor; Classical BAR domain containing |
| PRAP1 protein network | https://string-db.org/network/9606.ENSP00000416126 | Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells |
| TMEM238 protein network | https://string-db.org/network/9606.ENSP00000416154 | Transmembrane protein 238 |
| TRANK1 protein network | https://string-db.org/network/9606.ENSP00000416168 | Tetratricopeptide repeat and ankyrin repeat containing 1 |
| P2RX6 protein network | https://string-db.org/network/9606.ENSP00000416193 | P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel; Belongs to the P2X receptor family |
| GAGE12G protein network | https://string-db.org/network/9606.ENSP00000416249 | G antigen 12G; Belongs to the GAGE family |
| EIF2B1 protein network | https://string-db.org/network/9606.ENSP00000416250 | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP |
| EIF4G1 protein network | https://string-db.org/network/9606.ENSP00000416255 | Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary [...] |
| WDR27 protein network | https://string-db.org/network/9606.ENSP00000416289 | WD repeat-containing protein 27; WD repeat domain containing |
| SLC2A1 protein network | https://string-db.org/network/9606.ENSP00000416293 | Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad sub [...] |
| TGFBI protein network | https://string-db.org/network/9606.ENSP00000416330 | Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity) |
| NELL2 protein network | https://string-db.org/network/9606.ENSP00000416341 | Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the con [...] |
| FBLIM1 protein network | https://string-db.org/network/9606.ENSP00000416387 | Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. [...] |
| SLC9A8 protein network | https://string-db.org/network/9606.ENSP00000416418 | Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by th [...] |
| RPL32 protein network | https://string-db.org/network/9606.ENSP00000416429 | Ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family |
| ATP13A3 protein network | https://string-db.org/network/9606.ENSP00000416508 | Probable cation-transporting ATPase 13A3; ATPase orphan transporters |
| FDXR protein network | https://string-db.org/network/9606.ENSP00000416515 | NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogeni [...] |
| SEMA4D protein network | https://string-db.org/network/9606.ENSP00000416523 | Semaphorin-4D; Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth [...] |
| DDX46 protein network | https://string-db.org/network/9606.ENSP00000416534 | Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during splicing A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfam [...] |
| FBXO24 protein network | https://string-db.org/network/9606.ENSP00000416558 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| CFB protein network | https://string-db.org/network/9606.ENSP00000416561 | Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complem [...] |
| DERA protein network | https://string-db.org/network/9606.ENSP00000416583 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate. Participates in stress granu [...] |
| FSHB protein network | https://string-db.org/network/9606.ENSP00000416606 | Follitropin subunit beta; Stimulates development of follicle and spermatogenesis in the reproductive organs; Belongs to the glycoprotein hormones subunit beta family |
| NME6 protein network | https://string-db.org/network/9606.ENSP00000416658 | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism [...] |
| ZNF713 protein network | https://string-db.org/network/9606.ENSP00000416662 | Zinc finger protein 713; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PATL2 protein network | https://string-db.org/network/9606.ENSP00000416673 | Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor; Armadillo-like helical domain containing |
| IGFALS protein network | https://string-db.org/network/9606.ENSP00000416683 | Insulin-like growth factor-binding protein complex acid labile subunit; Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion |
| RIC1 protein network | https://string-db.org/network/9606.ENSP00000416696 | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required [...] |
| ACTBL2 protein network | https://string-db.org/network/9606.ENSP00000416706 | Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells |
| XKR6 protein network | https://string-db.org/network/9606.ENSP00000416707 | XK-related protein 6; XK related family; Belongs to the XK family |
| RECQL protein network | https://string-db.org/network/9606.ENSP00000416739 | ATP-dependent DNA helicase Q1; DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-heli [...] |
| HS3ST6 protein network | https://string-db.org/network/9606.ENSP00000416741 | Heparan sulfate glucosamine 3-O-sulfotransferase 6; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrat [...] |
| STK33 protein network | https://string-db.org/network/9606.ENSP00000416750 | Serine/threonine-protein kinase 33; Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosph [...] |
| MUC15 protein network | https://string-db.org/network/9606.ENSP00000416753 | Mucin-15; May play a role in the cell adhesion to the extracellular matrix; Mucins |
| GALNT11 protein network | https://string-db.org/network/9606.ENSP00000416787 | Polypeptide N-acetylgalactosaminyltransferase 11; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymm [...] |
| CAMSAP3 protein network | https://string-db.org/network/9606.ENSP00000416797 | Calmodulin-regulated spectrin-associated protein 3; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organ [...] |
| SPATA2 protein network | https://string-db.org/network/9606.ENSP00000416799 | Spermatogenesis-associated protein 2; May have a role in the regulation of spermatogenesis; Belongs to the SPATA2 family |
| ZNF679 protein network | https://string-db.org/network/9606.ENSP00000416809 | Zinc finger protein 679; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZC3H18 protein network | https://string-db.org/network/9606.ENSP00000416951 | Zinc finger CCCH-type containing 18 |
| TRA2B protein network | https://string-db.org/network/9606.ENSP00000416959 | Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively w [...] |
| MEPE protein network | https://string-db.org/network/9606.ENSP00000416984 | Matrix extracellular phosphoglycoprotein; Promotes renal phosphate excretion and modulates mineralization; SIBLING family |
| ACKR2 protein network | https://string-db.org/network/9606.ENSP00000416996 | Atypical chemokine receptor 2; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal [...] |
| PLEKHM3 protein network | https://string-db.org/network/9606.ENSP00000417003 | Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation. |
| C19orf81 protein network | https://string-db.org/network/9606.ENSP00000417035 | Putative uncharacterized protein C19orf81; Chromosome 19 open reading frame 81 |
| PHACTR2 protein network | https://string-db.org/network/9606.ENSP00000417038 | Phosphatase and actin regulator 2 |
| ENSG00000250349 protein network | https://string-db.org/network/9606.ENSP00000417050 | Tetraspanin; Uncharacterized protein; cDNA FLJ59144, highly similar to Tetraspanin-7 |
| EBP protein network | https://string-db.org/network/9606.ENSP00000417052 | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family |
| KIAA1751 protein network | https://string-db.org/network/9606.ENSP00000417061 | Cilia- and flagella-associated protein 74; As part of the central apparatus of the cilium axoneme may play a role in cilium movement |
| SPATA6L protein network | https://string-db.org/network/9606.ENSP00000417063 | Spermatogenesis-associated 6-like protein; Spermatogenesis associated 6 like |
| DHX36 protein network | https://string-db.org/network/9606.ENSP00000417078 | ATP-dependent RNA helicase DHX36; Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves te [...] |
| SLC15A2 protein network | https://string-db.org/network/9606.ENSP00000417085 | Solute carrier family 15 member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family |
| DEFB121 protein network | https://string-db.org/network/9606.ENSP00000417128 | Beta-defensin 121; Has antibacterial activity; Belongs to the beta-defensin family |
| BAP1 protein network | https://string-db.org/network/9606.ENSP00000417132 | Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB co [...] |
| PLTP protein network | https://string-db.org/network/9606.ENSP00000417138 | Phospholipid transfer protein; Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylgl [...] |
| NDUFA5 protein network | https://string-db.org/network/9606.ENSP00000417142 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| GPR143 protein network | https://string-db.org/network/9606.ENSP00000417161 | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SE [...] |
| VAPB protein network | https://string-db.org/network/9606.ENSP00000417175 | Vesicle-associated membrane protein-associated protein B/C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium [...] |
| DPCR1 protein network | https://string-db.org/network/9606.ENSP00000417182 | Diffuse panbronchiolitis critical region 1 |
| DUSP7 protein network | https://string-db.org/network/9606.ENSP00000417183 | Dual specificity protein phosphatase 7; Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L alth [...] |
| VWA1 protein network | https://string-db.org/network/9606.ENSP00000417185 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly; Fibronectin type III domain containing |
| ATPAF2 protein network | https://string-db.org/network/9606.ENSP00000417190 | ATP synthase mitochondrial F1 complex assembly factor 2; May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase); Belongs to the ATP12 family |
| ZNF80 protein network | https://string-db.org/network/9606.ENSP00000417192 | Zinc finger protein 80; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PCBP4 protein network | https://string-db.org/network/9606.ENSP00000417196 | Poly(rC)-binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC |
| HOXB3 protein network | https://string-db.org/network/9606.ENSP00000417207 | Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| PARP15 protein network | https://string-db.org/network/9606.ENSP00000417214 | Poly [ADP-ribose] polymerase 15; Possesses ADP-ribosyltransferase activity. Transcriptional repressor; Poly(ADP-ribose) polymerases |
| CPB1 protein network | https://string-db.org/network/9606.ENSP00000417222 | M14 carboxypeptidases; Belongs to the peptidase M14 family |
| EIF2A protein network | https://string-db.org/network/9606.ENSP00000417229 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosom [...] |
| MED12L protein network | https://string-db.org/network/9606.ENSP00000417235 | Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase [...] |
| RPSAP58 protein network | https://string-db.org/network/9606.ENSP00000417240 | Ribosomal protein SA pseudogene 58 |
| GPR156 protein network | https://string-db.org/network/9606.ENSP00000417261 | Probable G-protein coupled receptor 156; Orphan receptor; Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily |
| NCK1 protein network | https://string-db.org/network/9606.ENSP00000417273 | Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine- phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF [...] |
| REPIN1 protein network | https://string-db.org/network/9606.ENSP00000417291 | Replication initiator 1; Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the or [...] |
| KLF8 protein network | https://string-db.org/network/9606.ENSP00000417303 | Krueppel-like factor 8; Transcriptional repressor and activator. Binds to CACCC- boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) p [...] |
| KRTAP5-7 protein network | https://string-db.org/network/9606.ENSP00000417330 | Keratin-associated protein 5-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| ROBO2 protein network | https://string-db.org/network/9606.ENSP00000417335 | Roundabout homolog 2; Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the n [...] |
| GOLIM4 protein network | https://string-db.org/network/9606.ENSP00000417354 | Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi |
| ATP6V1F protein network | https://string-db.org/network/9606.ENSP00000417378 | ATPase H+ transporting V1 subunit F; V-type ATPases |
| HELZ2 protein network | https://string-db.org/network/9606.ENSP00000417401 | Helicase with zinc finger domain 2; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA; Belongs to the DNA2/NAM7 hel [...] |
| HFE protein network | https://string-db.org/network/9606.ENSP00000417404 | Hereditary hemochromatosis protein; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin; Belongs to the MHC class I family |
| DNAJB8 protein network | https://string-db.org/network/9606.ENSP00000417418 | DnaJ homolog subfamily B member 8; Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins; DNAJ heat shock proteins |
| RBMXL3 protein network | https://string-db.org/network/9606.ENSP00000417451 | RNA binding motif protein, X-linked like 3 |
| RRP1 protein network | https://string-db.org/network/9606.ENSP00000417464 | Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA; Belongs to the RRP1 family |
| ZNF786 protein network | https://string-db.org/network/9606.ENSP00000417470 | Zinc finger protein 786; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FHIT protein network | https://string-db.org/network/9606.ENSP00000417480 | Bis(5'-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'- adenosyl) tetraphosphate (Ap4A), but has extreme [...] |
| FSD1L protein network | https://string-db.org/network/9606.ENSP00000417492 | FSD1-like protein; Fibronectin type III and SPRY domain containing 1 like |
| MUC4 protein network | https://string-db.org/network/9606.ENSP00000417498 | Mucin-4; May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alt [...] |
| FAM208A protein network | https://string-db.org/network/9606.ENSP00000417509 | Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to [...] |
| SUPT20H protein network | https://string-db.org/network/9606.ENSP00000417510 | SPT20 homolog, SAGA complex component |
| ENSG00000173366 protein network | https://string-db.org/network/9606.ENSP00000417517 | annotation not available |
| CLASP2 protein network | https://string-db.org/network/9606.ENSP00000417518 | CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating fr [...] |
| DNAJC24 protein network | https://string-db.org/network/9606.ENSP00000417548 | DnaJ homolog subfamily C member 24; Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron-binding. The iron- bound form is redox-active and can functio [...] |
| ENSG00000251184 protein network | https://string-db.org/network/9606.ENSP00000417556 | Uncharacterized protein |
| STIM2 protein network | https://string-db.org/network/9606.ENSP00000417569 | Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive C [...] |
| YIPF6 protein network | https://string-db.org/network/9606.ENSP00000417573 | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression; Yip1 domain containing |
| IAH1 protein network | https://string-db.org/network/9606.ENSP00000417580 | Isoamyl acetate-hydrolyzing esterase 1 homolog; Probable lipase |
| FAM199X protein network | https://string-db.org/network/9606.ENSP00000417581 | Protein FAM199X; Family with sequence similarity 199, X-linked; Belongs to the FAM199 family |
| ST6GALNAC5 protein network | https://string-db.org/network/9606.ENSP00000417583 | Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins (By s [...] |
| FBXL2 protein network | https://string-db.org/network/9606.ENSP00000417601 | F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitina [...] |
| MRPL47 protein network | https://string-db.org/network/9606.ENSP00000417602 | Belongs to the universal ribosomal protein uL29 family. |
| C6orf1 protein network | https://string-db.org/network/9606.ENSP00000417604 | Uncharacterized protein SMIM29; Chromosome 6 open reading frame 1 |
| RAB23 protein network | https://string-db.org/network/9606.ENSP00000417610 | Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| TMEM176A protein network | https://string-db.org/network/9606.ENSP00000417626 | Transmembrane protein 176A; Membrane spanning 4-domains |
| SLC26A8 protein network | https://string-db.org/network/9606.ENSP00000417638 | Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meio [...] |
| DBNL protein network | https://string-db.org/network/9606.ENSP00000417653 | Drebrin-like protein; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formati [...] |
| SLC35A5 protein network | https://string-db.org/network/9606.ENSP00000417654 | Probable UDP-sugar transporter protein SLC35A5; Solute carrier family 35 member A5 |
| COX7B protein network | https://string-db.org/network/9606.ENSP00000417656 | Cytochrome c oxidase subunit 7B, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Play [...] |
| PTCHD3 protein network | https://string-db.org/network/9606.ENSP00000417658 | Patched domain-containing protein 3; May play a role in sperm development or sperm function |
| PPM1L protein network | https://string-db.org/network/9606.ENSP00000417659 | Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK [...] |
| ZBTB8OS protein network | https://string-db.org/network/9606.ENSP00000417677 | Protein archease; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation [...] |
| SLBP protein network | https://string-db.org/network/9606.ENSP00000417686 | Histone RNA hairpin-binding protein; RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to e [...] |
| ZNF525 protein network | https://string-db.org/network/9606.ENSP00000417696 | Zinc finger protein 525; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DCUN1D2 protein network | https://string-db.org/network/9606.ENSP00000417706 | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBC12. Neddylation of cullins play an [...] |
| DPPA2 protein network | https://string-db.org/network/9606.ENSP00000417710 | Developmental pluripotency-associated protein 2; Binds to target gene promoters, including NKX2-5 and SYCE1, but not GATA4, and may be involved in the maintenance of the active epigenetic status [...] |
| FAM205A protein network | https://string-db.org/network/9606.ENSP00000417711 | Protein FAM205A; Family with sequence similarity 205 member A |
| DDI2 protein network | https://string-db.org/network/9606.ENSP00000417748 | DNA damage inducible 1 homolog 2; Belongs to the DDI1 family |
| NAA10 protein network | https://string-db.org/network/9606.ENSP00000417763 | N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that ar [...] |
| ALG2 protein network | https://string-db.org/network/9606.ENSP00000417764 | Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)- dolichol diphosphate; Belongs to the gl [...] |
| IQUB protein network | https://string-db.org/network/9606.ENSP00000417769 | IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance |
| SMIM4 protein network | https://string-db.org/network/9606.ENSP00000417806 | Small integral membrane protein 4 |
| ANP32A protein network | https://string-db.org/network/9606.ENSP00000417864 | Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent a [...] |
| PAEP protein network | https://string-db.org/network/9606.ENSP00000417898 | Glycodelin; Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in [...] |
| GPHN protein network | https://string-db.org/network/9606.ENSP00000417901 | Gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Cataly [...] |
| ASB11 protein network | https://string-db.org/network/9606.ENSP00000417914 | Ankyrin repeat and SOCS box protein 11; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| TSPYL6 protein network | https://string-db.org/network/9606.ENSP00000417919 | Testis-specific Y-encoded-like protein 6; TSPY like 6 |
| VWA3B protein network | https://string-db.org/network/9606.ENSP00000417955 | Von Willebrand factor A domain containing 3B |
| PPP2R5D protein network | https://string-db.org/network/9606.ENSP00000417963 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the lo [...] |
| EHMT1 protein network | https://string-db.org/network/9606.ENSP00000417980 | Histone-lysine N-methyltransferase EHMT1; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me repre [...] |
| GK5 protein network | https://string-db.org/network/9606.ENSP00000418001 | Glycerol kinase 5 |
| MRPS22 protein network | https://string-db.org/network/9606.ENSP00000418008 | Mitochondrial ribosomal protein S22; Belongs to the mitochondrion-specific ribosomal protein mS22 family |
| RARRES2 protein network | https://string-db.org/network/9606.ENSP00000418009 | Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CM [...] |
| IFNE protein network | https://string-db.org/network/9606.ENSP00000418018 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Di [...] |
| PVRL3 protein network | https://string-db.org/network/9606.ENSP00000418070 | Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. T [...] |
| CACNA2D2 protein network | https://string-db.org/network/9606.ENSP00000418081 | Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...] |
| RPL37A protein network | https://string-db.org/network/9606.ENSP00000418082 | Ribosomal protein L37a |
| C3orf14 protein network | https://string-db.org/network/9606.ENSP00000418086 | Uncharacterized protein C3orf14; Chromosome 3 open reading frame 14 |
| PTPRG protein network | https://string-db.org/network/9606.ENSP00000418112 | Receptor-type tyrosine-protein phosphatase gamma; Possesses tyrosine phosphatase activity; Fibronectin type III domain containing |
| ZNF717 protein network | https://string-db.org/network/9606.ENSP00000418187 | Zinc finger protein 717; Zinc fingers C2H2-type |
| SPRR2F protein network | https://string-db.org/network/9606.ENSP00000418193 | Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane [...] |
| PARP14 protein network | https://string-db.org/network/9606.ENSP00000418194 | Poly [ADP-ribose] polymerase 14; ADP-ribosyltransferase. By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory [...] |
| RPL7L1 protein network | https://string-db.org/network/9606.ENSP00000418221 | Ribosomal protein L7 like 1 |
| ZFP57 protein network | https://string-db.org/network/9606.ENSP00000418259 | ZFP57 zinc finger protein; Zinc fingers C2H2-type |
| MCM10 protein network | https://string-db.org/network/9606.ENSP00000418268 | Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Addition [...] |
| CIAO1 protein network | https://string-db.org/network/9606.ENSP00000418287 | Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of [...] |
| CMC1 protein network | https://string-db.org/network/9606.ENSP00000418348 | COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome [...] |
| TAF1L protein network | https://string-db.org/network/9606.ENSP00000418379 | Transcription initiation factor TFIID subunit 1-like; May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced; Belongs to the [...] |
| IVD protein network | https://string-db.org/network/9606.ENSP00000418397 | Isovaleryl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase family |
| SRPRB protein network | https://string-db.org/network/9606.ENSP00000418401 | Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting [...] |
| CHCHD10 protein network | https://string-db.org/network/9606.ENSP00000418428 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial; May be involved in the maintenance of mitochondrial organization and mitochondrial cristae structure; Mitochondria [...] |
| NDUFA3 protein network | https://string-db.org/network/9606.ENSP00000418438 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| PPP2CA protein network | https://string-db.org/network/9606.ENSP00000418447 | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase [...] |
| LCN10 protein network | https://string-db.org/network/9606.ENSP00000418491 | Epididymal-specific lipocalin-10; Lipocalin 10; Belongs to the calycin superfamily. Lipocalin family |
| MME protein network | https://string-db.org/network/9606.ENSP00000418525 | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and L [...] |
| NSFL1C protein network | https://string-db.org/network/9606.ENSP00000418529 | NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a ro [...] |
| UGT1A3 protein network | https://string-db.org/network/9606.ENSP00000418532 | UDP-glucuronosyltransferase 1-3; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase [...] |
| U2SURP protein network | https://string-db.org/network/9606.ENSP00000418563 | U2 snRNP-associated SURP motif-containing protein; U2 snRNP associated SURP domain containing; Belongs to the splicing factor SR family |
| FAM19A1 protein network | https://string-db.org/network/9606.ENSP00000418575 | Protein FAM19A1; Family with sequence similarity 19 member A1, C-C motif chemokine like |
| SNX21 protein network | https://string-db.org/network/9606.ENSP00000418593 | Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular traff [...] |
| UBN2 protein network | https://string-db.org/network/9606.ENSP00000418648 | Ubinuclein-2; Ubinuclein 2; Belongs to the ubinuclein family |
| PTRH1 protein network | https://string-db.org/network/9606.ENSP00000418661 | peptidyl-tRNA hydrolase 1 homolog; Belongs to the PTH family |
| BOC protein network | https://string-db.org/network/9606.ENSP00000418663 | Brother of CDO; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells; Fibronectin type III [...] |
| MURC protein network | https://string-db.org/network/9606.ENSP00000418668 | Caveolae-associated protein 4; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within [...] |
| SEPHS2 protein network | https://string-db.org/network/9606.ENSP00000418669 | Selenide, water dikinase 2; Synthesizes selenophosphate from selenide and ATP; Selenoproteins |
| EFCAB10 protein network | https://string-db.org/network/9606.ENSP00000418678 | EF-hand calcium-binding domain-containing protein 10; EF-hand calcium binding domain 10 |
| RWDD2B protein network | https://string-db.org/network/9606.ENSP00000418693 | RWD domain containing 2B |
| PSMD6 protein network | https://string-db.org/network/9606.ENSP00000418695 | Proteasome 26S subunit, non-ATPase 6 |
| ZNF273 protein network | https://string-db.org/network/9606.ENSP00000418719 | Zinc finger protein 273; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PURG protein network | https://string-db.org/network/9606.ENSP00000418721 | Purine-rich element-binding protein gamma; Purine rich element binding protein G |
| MYSM1 protein network | https://string-db.org/network/9606.ENSP00000418734 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a co [...] |
| ADAMTS9 protein network | https://string-db.org/network/9606.ENSP00000418735 | A disintegrin and metalloproteinase with thrombospondin motifs 9; Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428- Glu-|-Ala-1 [...] |
| ESRP2 protein network | https://string-db.org/network/9606.ENSP00000418748 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelia [...] |
| BTBD9 protein network | https://string-db.org/network/9606.ENSP00000418751 | BTB/POZ domain-containing protein 9; BTB domain containing 9 |
| PTK7 protein network | https://string-db.org/network/9606.ENSP00000418754 | Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the [...] |
| TREML2 protein network | https://string-db.org/network/9606.ENSP00000418767 | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells e [...] |
| PARK7 protein network | https://string-db.org/network/9606.ENSP00000418770 | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive ca [...] |
| TIMMDC1 protein network | https://string-db.org/network/9606.ENSP00000418803 | Complex I assembly factor TIMMDC1, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing [...] |
| SELK protein network | https://string-db.org/network/9606.ENSP00000418813 | Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation [...] |
| FTO protein network | https://string-db.org/network/9606.ENSP00000418823 | Alpha-ketoglutarate-dependent dioxygenase FTO; Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methylurac [...] |
| NDUFA6 protein network | https://string-db.org/network/9606.ENSP00000418842 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved [...] |
| RPL29 protein network | https://string-db.org/network/9606.ENSP00000418868 | 60S ribosomal protein L29; Component of the large ribosomal subunit |
| PRSS50 protein network | https://string-db.org/network/9606.ENSP00000418875 | Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family |
| SELT protein network | https://string-db.org/network/9606.ENSP00000418910 | Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death . Involved in ADCYAP1/PACAP-induced ca [...] |
| CDKN2A protein network | https://string-db.org/network/9606.ENSP00000418915 | Cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cy [...] |
| PEG10 protein network | https://string-db.org/network/9606.ENSP00000418944 | Retrotransposon-derived protein PEG10; Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth prom [...] |
| BRCA1 protein network | https://string-db.org/network/9606.ENSP00000418960 | Breast cancer type 1 susceptibility protein; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by [...] |
| C6orf222 protein network | https://string-db.org/network/9606.ENSP00000418983 | Uncharacterized protein C6orf222; Chromosome 6 open reading frame 222 |
| SYNPR protein network | https://string-db.org/network/9606.ENSP00000418994 | Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity); Belongs to the synaptophysin/synaptobrevin family |
| LSAMP protein network | https://string-db.org/network/9606.ENSP00000419000 | Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic s [...] |
| NMD3 protein network | https://string-db.org/network/9606.ENSP00000419004 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit |
| DIEXF protein network | https://string-db.org/network/9606.ENSP00000419005 | Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs |
| PCCB protein network | https://string-db.org/network/9606.ENSP00000419027 | This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isole [...] |
| GFM1 protein network | https://string-db.org/network/9606.ENSP00000419038 | Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from t [...] |
| GCH1 protein network | https://string-db.org/network/9606.ENSP00000419045 | GTP cyclohydrolase 1; Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. [...] |
| CALML4 protein network | https://string-db.org/network/9606.ENSP00000419081 | Calmodulin-like protein 4; EF-hand domain containing; Belongs to the calmodulin family |
| TIGIT protein network | https://string-db.org/network/9606.ENSP00000419085 | T-cell immunoreceptor with Ig and ITIM domains; Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses [...] |
| NDUFB2 protein network | https://string-db.org/network/9606.ENSP00000419087 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not [...] |
| FAM162A protein network | https://string-db.org/network/9606.ENSP00000419088 | Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells [...] |
| CACNA2D3 protein network | https://string-db.org/network/9606.ENSP00000419101 | Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics o [...] |
| RPL35A protein network | https://string-db.org/network/9606.ENSP00000419117 | 60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator a [...] |
| FAM107A protein network | https://string-db.org/network/9606.ENSP00000419124 | Protein FAM107A; When transfected into cell lines in which it is not expressed, suppresses cell growth. May play a role in tumor development |
| C10orf88 protein network | https://string-db.org/network/9606.ENSP00000419126 | Uncharacterized protein C10orf88; Chromosome 10 open reading frame 88 |
| ZBTB20 protein network | https://string-db.org/network/9606.ENSP00000419153 | Zinc finger and BTB domain-containing protein 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses. Plays a role in postnatal myogenesis, may [...] |
| SPATA45 protein network | https://string-db.org/network/9606.ENSP00000419160 | Spermatogenesis-associated protein 45; Spermatogenesis associated 45; Belongs to the SPATA45 family |
| WDR86 protein network | https://string-db.org/network/9606.ENSP00000419162 | WD repeat-containing protein 86; WD repeat domain containing |
| SMYD3 protein network | https://string-db.org/network/9606.ENSP00000419184 | Histone-lysine N-methyltransferase SMYD3; Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Ly [...] |
| ONECUT2 protein network | https://string-db.org/network/9606.ENSP00000419185 | One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B; CUT class homeoboxes and pseudogenes |
| MSMP protein network | https://string-db.org/network/9606.ENSP00000419194 | Microseminoprotein, prostate associated; Belongs to the beta-microseminoprotein family |
| CAMKV protein network | https://string-db.org/network/9606.ENSP00000419195 | CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family |
| ASB14 protein network | https://string-db.org/network/9606.ENSP00000419199 | Ankyrin repeat and SOCS box protein 14; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquit [...] |
| FAM115A protein network | https://string-db.org/network/9606.ENSP00000419235 | TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell [...] |
| RIIAD1 protein network | https://string-db.org/network/9606.ENSP00000419249 | RIIa domain-containing protein 1; Regulatory subunit of type II PKA R-subunit domain containing 1 |
| EVX1 protein network | https://string-db.org/network/9606.ENSP00000419266 | Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types; HOXL subclass homeoboxes |
| PRKRIP1 protein network | https://string-db.org/network/9606.ENSP00000419270 | PRKR-interacting protein 1; Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity (By similarity); Zinc fingers C2H2-type |
| TTC26 protein network | https://string-db.org/network/9606.ENSP00000419279 | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary [...] |
| POU5F1B protein network | https://string-db.org/network/9606.ENSP00000419298 | Putative POU domain, class 5, transcription factor 1B; Shows weak transcriptional activator activity; POU class homeoboxes and pseudogenes |
| TRPC1 protein network | https://string-db.org/network/9606.ENSP00000419313 | Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...] |
| SUCLG2 protein network | https://string-db.org/network/9606.ENSP00000419325 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synt [...] |
| ADCY5 protein network | https://string-db.org/network/9606.ENSP00000419361 | Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosol [...] |
| MALSU1 protein network | https://string-db.org/network/9606.ENSP00000419370 | Mitochondrial assembly of ribosomal large subunit protein 1; May function as a ribosomal silencing factor. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation. In [...] |
| AZI2 protein network | https://string-db.org/network/9606.ENSP00000419371 | 5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine- protein kinase TBK1 and facilitates its oligom [...] |
| CLIC3 protein network | https://string-db.org/network/9606.ENSP00000419378 | Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control; Belongs to the chloride channel CLIC family |
| CDNF protein network | https://string-db.org/network/9606.ENSP00000419395 | Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-l [...] |
| ZNF782 protein network | https://string-db.org/network/9606.ENSP00000419397 | Zinc finger protein 782; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SLC4A2 protein network | https://string-db.org/network/9606.ENSP00000419412 | Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Solute carriers |
| C1orf52 protein network | https://string-db.org/network/9606.ENSP00000419417 | UPF0690 protein C1orf52; Chromosome 1 open reading frame 52; Belongs to the UPF0690 family |
| AGTR1 protein network | https://string-db.org/network/9606.ENSP00000419422 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| PPIA protein network | https://string-db.org/network/9606.ENSP00000419425 | Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclop [...] |
| ADAM9 protein network | https://string-db.org/network/9606.ENSP00000419446 | Disintegrin and metalloproteinase domain-containing protein 9; Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VC [...] |
| EIF1 protein network | https://string-db.org/network/9606.ENSP00000419449 | Eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of [...] |
| RNF183 protein network | https://string-db.org/network/9606.ENSP00000419454 | Probable E3 ubiquitin-protein ligase RNF183; May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restr [...] |
| NOBOX protein network | https://string-db.org/network/9606.ENSP00000419457 | Homeobox protein NOBOX; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG- 3' and 5'-TAATTA-3'; PRD class homeoboxes and p [...] |
| WWTR1 protein network | https://string-db.org/network/9606.ENSP00000419465 | WW domain-containing transcription regulator protein 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ [...] |
| RAD51B protein network | https://string-db.org/network/9606.ENSP00000419471 | DNA repair protein RAD51 homolog 2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. M [...] |
| COMMD2 protein network | https://string-db.org/network/9606.ENSP00000419475 | COMM domain-containing protein 2; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B; COMM domain containing |
| GCSAM protein network | https://string-db.org/network/9606.ENSP00000419485 | Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive re [...] |
| RYBP protein network | https://string-db.org/network/9606.ENSP00000419494 | RING1 and YY1-binding protein; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, incl [...] |
| LRRC75A protein network | https://string-db.org/network/9606.ENSP00000419502 | Leucine-rich repeat-containing protein 75A; Leucine rich repeat containing 75A |
| PTPLAD2 protein network | https://string-db.org/network/9606.ENSP00000419503 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; Catalyzes the third of the four reactions of the long- chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic proces [...] |
| LRRC55 protein network | https://string-db.org/network/9606.ENSP00000419542 | Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marke [...] |
| MAP3K6 protein network | https://string-db.org/network/9606.ENSP00000419591 | Mitogen-activated protein kinase kinase kinase 6; Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways |
| FAM122B protein network | https://string-db.org/network/9606.ENSP00000419592 | Protein FAM122B; Family with sequence similarity 122B; Belongs to the FAM122 family |
| DPH3 protein network | https://string-db.org/network/9606.ENSP00000419599 | DPH3 homolog; Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP- ribosyl [...] |
| NUDT5 protein network | https://string-db.org/network/9606.ENSP00000419628 | ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate. In absence of diphosph [...] |
| TMEM30C protein network | https://string-db.org/network/9606.ENSP00000419663 | Cell cycle control protein 50C; Transmembrane protein 30C; Belongs to the CDC50/LEM3 family |
| SSBP1 protein network | https://string-db.org/network/9606.ENSP00000419665 | Single-stranded DNA-binding protein, mitochondrial; This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication. Associates with mitochondria [...] |
| RXRA protein network | https://string-db.org/network/9606.ENSP00000419692 | Retinoic acid receptor RXR-alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retin [...] |
| TMEM8C protein network | https://string-db.org/network/9606.ENSP00000419712 | Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion react [...] |
| OFCC1 protein network | https://string-db.org/network/9606.ENSP00000419718 | Orofacial cleft 1 candidate 1 |
| NSUN4 protein network | https://string-db.org/network/9606.ENSP00000419740 | 5-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5- methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subu [...] |
| GGTLC2 protein network | https://string-db.org/network/9606.ENSP00000419751 | Gamma-glutamyltransferase light chain 2; Belongs to the gamma-glutamyltransferase family |
| BRD9 protein network | https://string-db.org/network/9606.ENSP00000419765 | Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that [...] |
| CDK5 protein network | https://string-db.org/network/9606.ENSP00000419782 | Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuron [...] |
| RGAG1 protein network | https://string-db.org/network/9606.ENSP00000419786 | Retrotransposon Gag-like protein 9; Retrotransposon gag domain containing 1 |
| GMPS protein network | https://string-db.org/network/9606.ENSP00000419851 | GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a [...] |
| CDS2 protein network | https://string-db.org/network/9606.ENSP00000419879 | Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin |
| L1TD1 protein network | https://string-db.org/network/9606.ENSP00000419901 | LINE1 type transposase domain containing 1; Belongs to the transposase 22 family |
| KLF6 protein network | https://string-db.org/network/9606.ENSP00000419923 | Krueppel-like factor 6; Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development; Belongs to the krueppel C2H2-type zinc-finger protein [...] |
| PXT1 protein network | https://string-db.org/network/9606.ENSP00000419944 | Peroxisomal, testis specific 1 |
| ERVW-1 protein network | https://string-db.org/network/9606.ENSP00000419945 | Syncytin-1; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morp [...] |
| KCNAB1 protein network | https://string-db.org/network/9606.ENSP00000419952 | Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its [...] |
| POR protein network | https://string-db.org/network/9606.ENSP00000419970 | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome [...] |
| PEX5L protein network | https://string-db.org/network/9606.ENSP00000419975 | PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence; Belongs t [...] |
| ENSG00000272762 protein network | https://string-db.org/network/9606.ENSP00000420008 | Poly(rC)-binding protein 4 |
| HOXB6 protein network | https://string-db.org/network/9606.ENSP00000420009 | Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| LYRM4 protein network | https://string-db.org/network/9606.ENSP00000420026 | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; LYR motif containing |
| PIGP protein network | https://string-db.org/network/9606.ENSP00000420037 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first [...] |
| KCNIP2 protein network | https://string-db.org/network/9606.ENSP00000420040 | Kv channel-interacting protein 2; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate o [...] |
| ABHD14B protein network | https://string-db.org/network/9606.ENSP00000420065 | Protein ABHD14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription; Abhydrolase domain containing |
| SERP1 protein network | https://string-db.org/network/9606.ENSP00000420076 | Stress-associated endoplasmic reticulum protein 1; Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against [...] |
| SLITRK3 protein network | https://string-db.org/network/9606.ENSP00000420091 | SLIT and NTRK-like protein 3; Suppresses neurite outgrowth |
| ZMYND8 protein network | https://string-db.org/network/9606.ENSP00000420095 | Protein kinase C-binding protein 1; May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis- associated genes; the function seems to [...] |
| RAB9A protein network | https://string-db.org/network/9606.ENSP00000420127 | Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans Golgi network. Involved in the recruitment of SGSM2 to melanosomes and is required for the pr [...] |
| PLSCR2 protein network | https://string-db.org/network/9606.ENSP00000420132 | Phospholipid scramblase 2; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...] |
| FAM71F2 protein network | https://string-db.org/network/9606.ENSP00000420140 | Protein FAM71F2; Family with sequence similarity 71 member F2 |
| B4GALT4 protein network | https://string-db.org/network/9606.ENSP00000420161 | Beta-1,4-galactosyltransferase 4; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the [...] |
| GSTA2 protein network | https://string-db.org/network/9606.ENSP00000420168 | Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family |
| ERVFRD-1 protein network | https://string-db.org/network/9606.ENSP00000420174 | Syncytin-2; This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morp [...] |
| POLE4 protein network | https://string-db.org/network/9606.ENSP00000420176 | DNA polymerase epsilon subunit 4; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function; DNA polymerases |
| CCDC14 protein network | https://string-db.org/network/9606.ENSP00000420180 | Coiled-coil domain-containing protein 14; Negatively regulates centriole duplication. Negatively regulates CEP63 and CDK2 centrosomal localization |
| IQCJ-SCHIP1 protein network | https://string-db.org/network/9606.ENSP00000420182 | IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial [...] |
| CASR protein network | https://string-db.org/network/9606.ENSP00000420194 | Extracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. [...] |
| SRSF10 protein network | https://string-db.org/network/9606.ENSP00000420195 | Serine/arginine-rich splicing factor 10; Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recogni [...] |
| ADPRH protein network | https://string-db.org/network/9606.ENSP00000420200 | [Protein ADP-ribosylarginine] hydrolase; Catalyzes the reverse reaction of mono-ADP-ribosylation |
| RGL2 protein network | https://string-db.org/network/9606.ENSP00000420211 | Ral guanine nucleotide dissociation stimulator-like 2; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in [...] |
| FLNB protein network | https://string-db.org/network/9606.ENSP00000420213 | Filamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various [...] |
| CPA5 protein network | https://string-db.org/network/9606.ENSP00000420237 | M14 carboxypeptidases; Belongs to the peptidase M14 family |
| CYLC2 protein network | https://string-db.org/network/9606.ENSP00000420256 | Cylicin-2; Possible architectural role during spermatogenesis. May be involved in spermatid differentiation |
| NR6A1 protein network | https://string-db.org/network/9606.ENSP00000420267 | Nuclear receptor subfamily 6 group A member 1; Orphan nuclear receptor. Binds to a response element containing the sequence 5'-TCAAGGTCA-3'. May be involved in the regulation of gene expression i [...] |
| ADH7 protein network | https://string-db.org/network/9606.ENSP00000420269 | Alcohol dehydrogenase class 4 mu/sigma chain; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and [...] |
| UHMK1 protein network | https://string-db.org/network/9606.ENSP00000420270 | Serine/threonine-protein kinase Kist; Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved i [...] |
| PHC3 protein network | https://string-db.org/network/9606.ENSP00000420294 | Polyhomeotic-like protein 3; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| PDE6B protein network | https://string-db.org/network/9606.ENSP00000420295 | Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a func [...] |
| CD200 protein network | https://string-db.org/network/9606.ENSP00000420298 | OX-2 membrane glycoprotein; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues; CD molecules |
| THOC5 protein network | https://string-db.org/network/9606.ENSP00000420306 | THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically ass [...] |
| RPL23 protein network | https://string-db.org/network/9606.ENSP00000420311 | Ribosomal protein L23 |
| ABHD6 protein network | https://string-db.org/network/9606.ENSP00000420315 | Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regu [...] |
| ROBO1 protein network | https://string-db.org/network/9606.ENSP00000420321 | Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neu [...] |
| ARMC8 protein network | https://string-db.org/network/9606.ENSP00000420333 | Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription fac [...] |
| RWDD1 protein network | https://string-db.org/network/9606.ENSP00000420357 | RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation; Belongs to the RWDD1/GIR2 family |
| CST7 protein network | https://string-db.org/network/9606.ENSP00000420384 | Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system; [...] |
| ATP11A protein network | https://string-db.org/network/9606.ENSP00000420387 | Probable phospholipid-transporting ATPase IH; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the out [...] |
| FSBP protein network | https://string-db.org/network/9606.ENSP00000420405 | Fibrinogen silencer-binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction [...] |
| ZNF398 protein network | https://string-db.org/network/9606.ENSP00000420418 | Zinc finger protein 398; Function as a transcriptional activator; Zinc fingers C2H2-type |
| CNIH4 protein network | https://string-db.org/network/9606.ENSP00000420443 | Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory [...] |
| RNF182 protein network | https://string-db.org/network/9606.ENSP00000420465 | E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway; Ring finger protein [...] |
| NACAD protein network | https://string-db.org/network/9606.ENSP00000420477 | NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge f [...] |
| OARD1 protein network | https://string-db.org/network/9606.ENSP00000420484 | O-acetyl-ADP-ribose deacetylase 1; Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes th [...] |
| ABHD14A-ACY1 protein network | https://string-db.org/network/9606.ENSP00000420487 | ABHD14A-ACY1 readthrough |
| LAT2 protein network | https://string-db.org/network/9606.ENSP00000420494 | Linker for activation of T-cells family member 2; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen r [...] |
| OR2A7 protein network | https://string-db.org/network/9606.ENSP00000420502 | Olfactory receptor 2A7; Odorant receptor; Olfactory receptors, family 2 |
| BAG1 protein network | https://string-db.org/network/9606.ENSP00000420514 | BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 p [...] |
| TFR2 protein network | https://string-db.org/network/9606.ENSP00000420525 | Transferrin receptor protein 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differen [...] |
| TFAM protein network | https://string-db.org/network/9606.ENSP00000420588 | Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recog [...] |
| EMC1 protein network | https://string-db.org/network/9606.ENSP00000420608 | ER membrane protein complex subunit 1; Belongs to the EMC1 family |
| C6orf201 protein network | https://string-db.org/network/9606.ENSP00000420610 | Uncharacterized protein C6orf201; Chromosome 6 open reading frame 201 |
| TIPARP protein network | https://string-db.org/network/9606.ENSP00000420612 | TCDD-inducible poly [ADP-ribose] polymerase; Poly [ADP-ribose] polymerase using NAD(+) as a substrate to transfer ADP-ribose onto glutamic acid residues of a protein acceptor; repeated rounds of [...] |
| DP2 protein network | https://string-db.org/network/9606.ENSP00000420616 | Transcription factor Dp-2; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter reg [...] |
| MFN1 protein network | https://string-db.org/network/9606.ENSP00000420617 | Mitofusin-1; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coile [...] |
| TMEM14B protein network | https://string-db.org/network/9606.ENSP00000420658 | Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn p [...] |
| KLHL29 protein network | https://string-db.org/network/9606.ENSP00000420659 | Kelch-like protein 29; Kelch like family member 29; BTB domain containing |
| QTRTD1 protein network | https://string-db.org/network/9606.ENSP00000420682 | Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) [...] |
| PLCXD2 protein network | https://string-db.org/network/9606.ENSP00000420686 | PI-PLC X domain-containing protein 2; Phosphatidylinositol specific phospholipase C X domain containing 2 |
| MRPS14 protein network | https://string-db.org/network/9606.ENSP00000420714 | Mitochondrial ribosomal protein S14; Belongs to the universal ribosomal protein uS14 family |
| C1orf228 protein network | https://string-db.org/network/9606.ENSP00000420716 | Uncharacterized protein C1orf228; Chromosome 1 open reading frame 228 |
| KRTAP5-8 protein network | https://string-db.org/network/9606.ENSP00000420723 | Keratin-associated protein 5-8; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| ZNF181 protein network | https://string-db.org/network/9606.ENSP00000420727 | Zinc finger protein 181; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PRB1 protein network | https://string-db.org/network/9606.ENSP00000420826 | Basic salivary proline-rich protein 1; Proline rich protein BstNI subfamily 1 |
| PCDHA1 protein network | https://string-db.org/network/9606.ENSP00000420840 | Protocadherin alpha-1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| NIM1K protein network | https://string-db.org/network/9606.ENSP00000420849 | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family |
| EFCAB12 protein network | https://string-db.org/network/9606.ENSP00000420854 | EF-hand calcium-binding domain-containing protein 12; EF-hand calcium binding domain 12 |
| RMND5B protein network | https://string-db.org/network/9606.ENSP00000420875 | Protein RMD5 homolog B; Required for meiotic nuclear division 5 homolog B |
| HSD17B4 protein network | https://string-db.org/network/9606.ENSP00000420914 | Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta- oxidation pathway for fatty acids. Catalyzes the formation of 3- ketoacyl-CoA intermediates from bot [...] |
| TMEM150C protein network | https://string-db.org/network/9606.ENSP00000420919 | Transmembrane protein 150C; Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception; Belongs [...] |
| PDK2 protein network | https://string-db.org/network/9606.ENSP00000420927 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphoryla [...] |
| SEPP1 protein network | https://string-db.org/network/9606.ENSP00000420939 | Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues su [...] |
| C4orf36 protein network | https://string-db.org/network/9606.ENSP00000420949 | Uncharacterized protein C4orf36; Chromosome 4 open reading frame 36 |
| DLEU7 protein network | https://string-db.org/network/9606.ENSP00000420976 | Leukemia-associated protein 7; Deleted in lymphocytic leukemia, 7 |
| SPINK13 protein network | https://string-db.org/network/9606.ENSP00000421048 | Serine protease inhibitor Kazal-type 13; May be a serine protease inhibitor (By similarity). Essential for sperm maturation and fertility. Inhibits sperm acrosome reaction, protecting sperm from [...] |
| ATP5L2 protein network | https://string-db.org/network/9606.ENSP00000421076 | ATP synthase subunit g 2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane wh [...] |
| FAM90A26 protein network | https://string-db.org/network/9606.ENSP00000421131 | Putative protein FAM90A5P; Family with sequence similarity 90 member A26; Belongs to the FAM90 family |
| TRIM60 protein network | https://string-db.org/network/9606.ENSP00000421142 | Tripartite motif containing 60; Belongs to the TRIM/RBCC family |
| BEND4 protein network | https://string-db.org/network/9606.ENSP00000421169 | BEN domain containing 4 |
| AWAT2 protein network | https://string-db.org/network/9606.ENSP00000421172 | Acyl-CoA wax alcohol acyltransferase 2; Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in s [...] |
| MAML3 protein network | https://string-db.org/network/9606.ENSP00000421180 | Mastermind-like protein 3; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1; Belongs to the mastermind family |
| MGAT4D protein network | https://string-db.org/network/9606.ENSP00000421185 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surf [...] |
| IGSF22 protein network | https://string-db.org/network/9606.ENSP00000421191 | Immunoglobulin superfamily, member 22; Fibronectin type III domain containing |
| CLDND1 protein network | https://string-db.org/network/9606.ENSP00000421226 | Claudin domain containing 1 |
| LY6G6F-LY6G6D protein network | https://string-db.org/network/9606.ENSP00000421232 | HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein |
| ZNF131 protein network | https://string-db.org/network/9606.ENSP00000421246 | Zinc finger protein 131; Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regul [...] |
| ZNF154 protein network | https://string-db.org/network/9606.ENSP00000421258 | Zinc finger protein 154; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SLC10A7 protein network | https://string-db.org/network/9606.ENSP00000421275 | Sodium/bile acid cotransporter 7; Solute carrier family 10 member 7; Belongs to the unknown BART superfamily-1 (UBS1) (TC 2.A.93) family |
| MYO10 protein network | https://string-db.org/network/9606.ENSP00000421280 | Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles an [...] |
| SH3D21 protein network | https://string-db.org/network/9606.ENSP00000421294 | SH3 domain containing 21 |
| ENSG00000250424 protein network | https://string-db.org/network/9606.ENSP00000421315 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family |
| ATP2C1 protein network | https://string-db.org/network/9606.ENSP00000421326 | Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium; Belongs to the cation transport ATPase (P- [...] |
| SLCO6A1 protein network | https://string-db.org/network/9606.ENSP00000421339 | Solute carrier organic anion transporter family member 6A1 |
| PIEZO2 protein network | https://string-db.org/network/9606.ENSP00000421377 | Piezo-type mechanosensitive ion channel component 2; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotr [...] |
| SNF8 protein network | https://string-db.org/network/9606.ENSP00000421380 | Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal [...] |
| ROPN1L protein network | https://string-db.org/network/9606.ENSP00000421405 | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermat [...] |
| TIGD5 protein network | https://string-db.org/network/9606.ENSP00000421489 | Tigger transposable element-derived protein 5; Helix-turn-helix CENPB type domain containing; DNA transposon derived genes |
| XRCC4 protein network | https://string-db.org/network/9606.ENSP00000421491 | DNA repair protein XRCC4; Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRC [...] |
| PCBD2 protein network | https://string-db.org/network/9606.ENSP00000421544 | Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By simila [...] |
| GPR33 protein network | https://string-db.org/network/9606.ENSP00000421557 | Probable G-protein coupled receptor 33; Orphan receptor; could be a chemoattractant receptor; Belongs to the G-protein coupled receptor 1 family |
| XPNPEP1 protein network | https://string-db.org/network/9606.ENSP00000421566 | Xaa-Pro aminopeptidase 1; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro; Aminopeptidases |
| ALYREF protein network | https://string-db.org/network/9606.ENSP00000421592 | THO complex subunit 4; Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pat [...] |
| SPDYE2 protein network | https://string-db.org/network/9606.ENSP00000421686 | Speedy protein E2; speedy/RINGO cell cycle regulator family member E2; Belongs to the Speedy/Ringo family |
| CSNK1A1 protein network | https://string-db.org/network/9606.ENSP00000421689 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of [...] |
| GC protein network | https://string-db.org/network/9606.ENSP00000421725 | Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation an [...] |
| CR1L protein network | https://string-db.org/network/9606.ENSP00000421736 | Complement component receptor 1-like protein; Complement C3b/C4b receptor 1 like; Belongs to the receptors of complement activation (RCA) family |
| ENSG00000257184 protein network | https://string-db.org/network/9606.ENSP00000421799 | Uncharacterized protein |
| HGFAC protein network | https://string-db.org/network/9606.ENSP00000421801 | Hepatocyte growth factor activator; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form; Belongs to the peptidase S1 family |
| GABRA2 protein network | https://string-db.org/network/9606.ENSP00000421828 | Gamma-aminobutyric acid receptor subunit alpha-2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| ANAPC13 protein network | https://string-db.org/network/9606.ENSP00000421842 | Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| RANBP3L protein network | https://string-db.org/network/9606.ENSP00000421853 | Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocki [...] |
| MAGED4B protein network | https://string-db.org/network/9606.ENSP00000421861 | Melanoma antigen family D, 4B; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...] |
| CCDC169-SOHLH2 protein network | https://string-db.org/network/9606.ENSP00000421868 | CCDC169-SOHLH2 readthrough |
| DCANP1 protein network | https://string-db.org/network/9606.ENSP00000421871 | Dendritic cell nuclear protein 1; Binds with and transactivates the corticotropin- releasing hormone (CRH) promoter |
| ZNF672 protein network | https://string-db.org/network/9606.ENSP00000421915 | Zinc finger protein 672; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HMGXB3 protein network | https://string-db.org/network/9606.ENSP00000421917 | HMG domain-containing protein 3; Non-canonical high mobility group |
| LRPAP1 protein network | https://string-db.org/network/9606.ENSP00000421922 | Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway; Belongs to th [...] |
| PRRC1 protein network | https://string-db.org/network/9606.ENSP00000421965 | Protein PRRC1; Proline rich coiled-coil 1; Belongs to the PRRC1 family |
| PAQR3 protein network | https://string-db.org/network/9606.ENSP00000421981 | Progestin and adipoQ receptor family member 3; Functions as a spatial regulator of RAF1 kinase by sequestrating it to the Golgi; Progestin and adipoQ receptor family |
| FNIP1 protein network | https://string-db.org/network/9606.ENSP00000421985 | Folliculin-interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client pr [...] |
| PSG7 protein network | https://string-db.org/network/9606.ENSP00000421986 | Pregnancy specific beta-1-glycoprotein 7; Belongs to the immunoglobulin superfamily. CEA family |
| ACTN3 protein network | https://string-db.org/network/9606.ENSP00000422007 | Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins |
| NFXL1 protein network | https://string-db.org/network/9606.ENSP00000422037 | NF-X1-type zinc finger protein NFXL1; Nuclear transcription factor, X-box binding like 1; Belongs to the NFX1 family |
| FAM47E-STBD1 protein network | https://string-db.org/network/9606.ENSP00000422067 | FAM47E-STBD1 readthrough |
| USP17L25 protein network | https://string-db.org/network/9606.ENSP00000422097 | Ubiquitin specific peptidase 17-like family member 25; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| FAM193B protein network | https://string-db.org/network/9606.ENSP00000422131 | Protein FAM193B; Family with sequence similarity 193 member B; Belongs to the FAM193 family |
| SH3BP2 protein network | https://string-db.org/network/9606.ENSP00000422168 | SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase [...] |
| SORCS2 protein network | https://string-db.org/network/9606.ENSP00000422185 | Sortilin related VPS10 domain containing receptor 2; Belongs to the VPS10-related sortilin family. SORCS subfamily |
| TTC23L protein network | https://string-db.org/network/9606.ENSP00000422188 | Tetratricopeptide repeat domain 23 like |
| USP17L21 protein network | https://string-db.org/network/9606.ENSP00000422216 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 21; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| FAM173B protein network | https://string-db.org/network/9606.ENSP00000422338 | Protein FAM173B; Seven-beta-strand methyltransferase motif containing; Belongs to the FAM173 family |
| GSTCD protein network | https://string-db.org/network/9606.ENSP00000422354 | Glutathione S-transferase C-terminal domain containing; Belongs to the GSTCD family |
| NUDT16 protein network | https://string-db.org/network/9606.ENSP00000422375 | U8 snoRNA-decapping enzyme; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that [...] |
| LSM6 protein network | https://string-db.org/network/9606.ENSP00000422392 | U6 snRNA-associated Sm-like protein LSm6; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient associat [...] |
| TMEM158 protein network | https://string-db.org/network/9606.ENSP00000422431 | Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide |
| PDGFC protein network | https://string-db.org/network/9606.ENSP00000422464 | Platelet-derived growth factor C; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitoge [...] |
| TMEM33 protein network | https://string-db.org/network/9606.ENSP00000422473 | Transmembrane protein 33; Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and [...] |
| ESRRB protein network | https://string-db.org/network/9606.ENSP00000422488 | Steroid hormone receptor ERR2; Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulati [...] |
| TTC39B protein network | https://string-db.org/network/9606.ENSP00000422496 | Tetratricopeptide repeat domain containing; Belongs to the TTC39 family |
| LPHN3 protein network | https://string-db.org/network/9606.ENSP00000422533 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays [...] |
| ADAMTS12 protein network | https://string-db.org/network/9606.ENSP00000422554 | A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumor [...] |
| TRIML2 protein network | https://string-db.org/network/9606.ENSP00000422581 | Probable E3 ubiquitin-protein ligase TRIML2; Tripartite motif family like 2 |
| SLIT2 protein network | https://string-db.org/network/9606.ENSP00000422591 | Slit homolog 2 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural develop [...] |
| ACSL1 protein network | https://string-db.org/network/9606.ENSP00000422607 | Long-chain-fatty-acid--CoA ligase 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and l [...] |
| USP17L17 protein network | https://string-db.org/network/9606.ENSP00000422621 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 17; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| LARP7 protein network | https://string-db.org/network/9606.ENSP00000422626 | La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b [...] |
| DDX41 protein network | https://string-db.org/network/9606.ENSP00000422753 | Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing; Belongs to the DEAD [...] |
| DNAH10OS protein network | https://string-db.org/network/9606.ENSP00000422769 | Uncharacterized protein DNAH10OS; Dynein axonemal heavy chain 10 opposite strand |
| USP17L30 protein network | https://string-db.org/network/9606.ENSP00000422887 | Ubiquitin specific peptidase 17-like family member 30; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| GTF2H2C protein network | https://string-db.org/network/9606.ENSP00000422907 | General transcription factor IIH subunit 2-like protein; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in [...] |
| STIMATE-MUSTN1 protein network | https://string-db.org/network/9606.ENSP00000422941 | annotation not available |
| TRIM34 protein network | https://string-db.org/network/9606.ENSP00000422947 | Tripartite motif containing 34; May function as antiviral protein and may contribute to the defense against retroviral infections; Belongs to the TRIM/RBCC family |
| USP17L29 protein network | https://string-db.org/network/9606.ENSP00000422969 | Ubiquitin specific peptidase 17-like family member 29; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| OCIAD2 protein network | https://string-db.org/network/9606.ENSP00000423014 | OCIA domain containing 2 |
| WDR36 protein network | https://string-db.org/network/9606.ENSP00000423067 | WD repeat-containing protein 36; Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2; UTPb subcomplex |
| CXorf40A protein network | https://string-db.org/network/9606.ENSP00000423099 | Protein CXorf40A; May have an important role of cell protection in inflammation reaction |
| USP17L22 protein network | https://string-db.org/network/9606.ENSP00000423115 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 22; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| GOLGA8O protein network | https://string-db.org/network/9606.ENSP00000423159 | Golgin A8 family member O; Belongs to the GOLGA6 family |
| AADAT protein network | https://string-db.org/network/9606.ENSP00000423190 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. [...] |
| USP17L27 protein network | https://string-db.org/network/9606.ENSP00000423211 | Ubiquitin specific peptidase 17-like family member 27; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| ZCCHC10 protein network | https://string-db.org/network/9606.ENSP00000423276 | Zinc finger CCHC-type containing 10 |
| ENSG00000270249 protein network | https://string-db.org/network/9606.ENSP00000423309 | Uncharacterized protein |
| GALNTL6 protein network | https://string-db.org/network/9606.ENSP00000423313 | Polypeptide N-acetylgalactosaminyltransferase-like 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or [...] |
| USP51 protein network | https://string-db.org/network/9606.ENSP00000423333 | Ubiquitin carboxyl-terminal hydrolase 51; Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). [...] |
| KIAA1211 protein network | https://string-db.org/network/9606.ENSP00000423366 | Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping protein [...] |
| USP26 protein network | https://string-db.org/network/9606.ENSP00000423390 | Ubiquitin carboxyl-terminal hydrolase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and [...] |
| RFPL4B protein network | https://string-db.org/network/9606.ENSP00000423391 | Ret finger protein like 4B; Ring finger proteins |
| MRPL36 protein network | https://string-db.org/network/9606.ENSP00000423399 | Mitochondrial ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family |
| LY75-CD302 protein network | https://string-db.org/network/9606.ENSP00000423463 | LY75-CD302 readthrough |
| USP17L18 protein network | https://string-db.org/network/9606.ENSP00000423503 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 18; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| TTC29 protein network | https://string-db.org/network/9606.ENSP00000423505 | Tetratricopeptide repeat domain containing |
| SV2C protein network | https://string-db.org/network/9606.ENSP00000423541 | Synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates ves [...] |
| ENSG00000258838 protein network | https://string-db.org/network/9606.ENSP00000423550 | Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ER [...] |
| H2AFY protein network | https://string-db.org/network/9606.ENSP00000423563 | Core histone macro-H2A.1; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limitin [...] |
| CCDC153 protein network | https://string-db.org/network/9606.ENSP00000423567 | Coiled-coil domain containing 153; Belongs to the UPF0610 family |
| MTX3 protein network | https://string-db.org/network/9606.ENSP00000423600 | Metaxin-3; Could function in transport of proteins into the mitochondrion; Belongs to the metaxin family |
| DAPP1 protein network | https://string-db.org/network/9606.ENSP00000423602 | Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; May act as a B-cell-associated adapter that regulates B- cell antigen receptor (BCR)-signaling downstream of PI3K; P [...] |
| FBXL7 protein network | https://string-db.org/network/9606.ENSP00000423630 | F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal de [...] |
| SH3TC2 protein network | https://string-db.org/network/9606.ENSP00000423660 | SH3 domain and tetratricopeptide repeats 2 |
| CDK18 protein network | https://string-db.org/network/9606.ENSP00000423665 | Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Cyclin dependent kinases |
| NDUFA13 protein network | https://string-db.org/network/9606.ENSP00000423673 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involve [...] |
| GNPDA1 protein network | https://string-db.org/network/9606.ENSP00000423674 | Glucosamine-6-phosphate isomerase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the emb [...] |
| USP17L28 protein network | https://string-db.org/network/9606.ENSP00000423777 | Ubiquitin specific peptidase 17-like family member 28; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| CHAD protein network | https://string-db.org/network/9606.ENSP00000423812 | Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play a [...] |
| ZFP62 protein network | https://string-db.org/network/9606.ENSP00000423820 | Zinc finger protein 62 homolog; May play a role in differentiating skeletal muscle; Zinc fingers C2H2-type |
| GPX8 protein network | https://string-db.org/network/9606.ENSP00000423822 | Glutathione peroxidase 8; Belongs to the glutathione peroxidase family |
| PACRGL protein network | https://string-db.org/network/9606.ENSP00000423881 | PACRG-like protein; Armadillo-like helical domain containing |
| KLHL5 protein network | https://string-db.org/network/9606.ENSP00000423897 | Kelch-like protein 5; Kelch like family member 5; BTB domain containing |
| NPY5R protein network | https://string-db.org/network/9606.ENSP00000423917 | Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated [...] |
| THUMPD2 protein network | https://string-db.org/network/9606.ENSP00000423933 | THUMP domain-containing protein 2; Seven-beta-strand methyltransferase motif containing; Belongs to the methyltransferase superfamily |
| SHLD3 protein network | https://string-db.org/network/9606.ENSP00000424007 | CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein |
| FRG2 protein network | https://string-db.org/network/9606.ENSP00000424015 | Protein FRG2; FSHD region gene 2 |
| TAS2R50 protein network | https://string-db.org/network/9606.ENSP00000424040 | Taste receptor type 2 member 50; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| SPDYE2B protein network | https://string-db.org/network/9606.ENSP00000424058 | Speedy protein E2B; speedy/RINGO cell cycle regulator family member E2B |
| USP17L23 protein network | https://string-db.org/network/9606.ENSP00000424077 | Putative ubiquitin carboxyl-terminal hydrolase 17-like protein 23; Ubiquitin specific peptidase 17-like family member 23 |
| NHSL2 protein network | https://string-db.org/network/9606.ENSP00000424079 | NHS-like protein 2; NHS like 2 |
| ELOVL7 protein network | https://string-db.org/network/9606.ENSP00000424123 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| MCTP1 protein network | https://string-db.org/network/9606.ENSP00000424126 | Multiple C2 and transmembrane domain-containing protein 1; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term [...] |
| WAP7 protein network | https://string-db.org/network/9606.ENSP00000424176 | EPPIN-WFDC6 readthrough; Serine protease inhibitor that plays an essential role in male reproduction and fertility. Modulates the hydrolysis of SEMG1 by KLK3/PSA (a serine protease), provides ant [...] |
| LAMTOR3 protein network | https://string-db.org/network/9606.ENSP00000424183 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth [...] |
| SMUG1 protein network | https://string-db.org/network/9606.ENSP00000424191 | Single-strand selective monofunctional uracil DNA glycosylase; Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for [...] |
| KLHL2 protein network | https://string-db.org/network/9606.ENSP00000424198 | Kelch-like protein 2; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most oft [...] |
| TENM3 protein network | https://string-db.org/network/9606.ENSP00000424226 | Teneurin-3; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the [...] |
| EYS protein network | https://string-db.org/network/9606.ENSP00000424243 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells; Belongs to the EYS family |
| PTTG2 protein network | https://string-db.org/network/9606.ENSP00000424261 | Securin-2; Pituitary tumor-transforming 2; Belongs to the securin family |
| MRPS30 protein network | https://string-db.org/network/9606.ENSP00000424328 | Mitochondrial ribosomal protein S30 |
| ENSG00000251569 protein network | https://string-db.org/network/9606.ENSP00000424363 | Bardet-Biedl syndrome 5 protein; Uncharacterized protein |
| LMF2 protein network | https://string-db.org/network/9606.ENSP00000424381 | Lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through t [...] |
| SPATS1 protein network | https://string-db.org/network/9606.ENSP00000424400 | Spermatogenesis-associated serine-rich protein 1; Spermatogenesis associated serine rich 1 |
| PLRG1 protein network | https://string-db.org/network/9606.ENSP00000424417 | Pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing |
| SAMD14 protein network | https://string-db.org/network/9606.ENSP00000424474 | Sterile alpha motif domain containing 14 |
| SH3RF2 protein network | https://string-db.org/network/9606.ENSP00000424497 | Putative E3 ubiquitin-protein ligase SH3RF2; Inhibits PPP1CA phosphatase activity. May be a E3 ubiquitin-protein ligase (Potential). May play a role in cardiac function; Belongs to the SH3RF fami [...] |
| HTN1 protein network | https://string-db.org/network/9606.ENSP00000424501 | Histatin-1; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibi [...] |
| TUSC3 protein network | https://string-db.org/network/9606.ENSP00000424544 | Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked olig [...] |
| CDHR2 protein network | https://string-db.org/network/9606.ENSP00000424565 | Cadherin-related family member 2; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, [...] |
| SLC35A4 protein network | https://string-db.org/network/9606.ENSP00000424566 | Probable UDP-sugar transporter protein SLC35A4; Solute carrier family 35 member A4; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily |
| FBN2 protein network | https://string-db.org/network/9606.ENSP00000424571 | Fibrillin-2; Fibrillin-2: Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. [...] |
| PRPS1L1 protein network | https://string-db.org/network/9606.ENSP00000424595 | Ribose-phosphate pyrophosphokinase 3; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis |
| DEFB4B protein network | https://string-db.org/network/9606.ENSP00000424598 | Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse [...] |
| TAAR9 protein network | https://string-db.org/network/9606.ENSP00000424607 | Trace amine-associated receptor 9; Orphan receptor. Could be a receptor for trace amines. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace ami [...] |
| TMEM167A protein network | https://string-db.org/network/9606.ENSP00000424707 | Protein kish-A; Involved in the early part of the secretory pathway |
| CLRN2 protein network | https://string-db.org/network/9606.ENSP00000424711 | Clarin-2; Clarin 2; Clarins |
| ZGRF1 protein network | https://string-db.org/network/9606.ENSP00000424737 | Protein ZGRF1; Zinc finger GRF-type containing 1; UPF1 like RNA helicases |
| NEK1 protein network | https://string-db.org/network/9606.ENSP00000424757 | Serine/threonine-protein kinase Nek1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (By similarity). Involved in DNA damage checkpoint control and fo [...] |
| AMOTL2 protein network | https://string-db.org/network/9606.ENSP00000424765 | Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-c [...] |
| MSANTD3-TMEFF1 protein network | https://string-db.org/network/9606.ENSP00000424768 | MSANTD3-TMEFF1 readthrough |
| NEDD4 protein network | https://string-db.org/network/9606.ENSP00000424827 | E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin [...] |
| DDX4 protein network | https://string-db.org/network/9606.ENSP00000424838 | Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essenti [...] |
| SRP19 protein network | https://string-db.org/network/9606.ENSP00000424870 | Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP |
| CNOT6L protein network | https://string-db.org/network/9606.ENSP00000424896 | CCR4-NOT transcription complex subunit 6-like; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the majo [...] |
| ENSG00000187695 protein network | https://string-db.org/network/9606.ENSP00000424951 | Uncharacterized protein FLJ43738 |
| CCSER1 protein network | https://string-db.org/network/9606.ENSP00000425040 | Coiled-coil serine rich protein 1 |
| DTWD2 protein network | https://string-db.org/network/9606.ENSP00000425048 | DTW domain containing 2 |
| LUC7L3 protein network | https://string-db.org/network/9606.ENSP00000425092 | Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing; Belongs to the Luc7 family |
| CDH18 protein network | https://string-db.org/network/9606.ENSP00000425093 | Cadherin-18; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| ATG12 protein network | https://string-db.org/network/9606.ENSP00000425107 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like [...] |
| SMG7 protein network | https://string-db.org/network/9606.ENSP00000425133 | Protein SMG7; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery invol [...] |
| C1orf216 protein network | https://string-db.org/network/9606.ENSP00000425166 | UPF0500 protein C1orf216; Chromosome 1 open reading frame 216 |
| COX18 protein network | https://string-db.org/network/9606.ENSP00000425261 | Mitochondrial inner membrane protein COX18; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c [...] |
| USP17L24 protein network | https://string-db.org/network/9606.ENSP00000425375 | Ubiquitin specific peptidase 17-like family member 24; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include c [...] |
| ABLIM3 protein network | https://string-db.org/network/9606.ENSP00000425394 | Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity; LIM domain containing |
| SATL1 protein network | https://string-db.org/network/9606.ENSP00000425421 | Spermidine/spermine N1-acetyl transferase like 1; GCN5 related N-acetyltransferases |
| INPP4B protein network | https://string-db.org/network/9606.ENSP00000425487 | Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisp [...] |
| CAGE1 protein network | https://string-db.org/network/9606.ENSP00000425493 | Cancer-associated gene 1 protein; Cancer antigen 1 |
| ENSG00000270386 protein network | https://string-db.org/network/9606.ENSP00000425497 | UDP-glucuronosyltransferase 2A1; UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus; Belongs to the UDP-glycosyltransferase family |
| PALLD protein network | https://string-db.org/network/9606.ENSP00000425556 | Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in [...] |
| EIF4E protein network | https://string-db.org/network/9606.ENSP00000425561 | Eukaryotic translation initiation factor 4E |
| USP17L19 protein network | https://string-db.org/network/9606.ENSP00000425582 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 19; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| EXOC3 protein network | https://string-db.org/network/9606.ENSP00000425587 | Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane |
| HARS protein network | https://string-db.org/network/9606.ENSP00000425634 | Histidine--tRNA ligase, cytoplasmic; Cytoplasmic histidine--tRNA ligase (Probable). Plays a role in axon guidance; Aminoacyl tRNA synthetases, Class II |
| ANKRD50 protein network | https://string-db.org/network/9606.ENSP00000425658 | Ankyrin repeat domain-containing protein 50; Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1; Ankyrin repeat domain [...] |
| CCDC149 protein network | https://string-db.org/network/9606.ENSP00000425715 | Coiled-coil domain containing 149 |
| COX7C protein network | https://string-db.org/network/9606.ENSP00000425759 | Cytochrome c oxidase subunit 7C, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| C4orf22 protein network | https://string-db.org/network/9606.ENSP00000425786 | Uncharacterized protein C4orf22; Chromosome 4 open reading frame 22 |
| PGM3 protein network | https://string-db.org/network/9606.ENSP00000425809 | Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylati [...] |
| RNF150 protein network | https://string-db.org/network/9606.ENSP00000425840 | Ring finger protein 150 |
| MEF2BNB protein network | https://string-db.org/network/9606.ENSP00000425864 | BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BO [...] |
| USP17L5 protein network | https://string-db.org/network/9606.ENSP00000425955 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 5; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...] |
| SPINK2 protein network | https://string-db.org/network/9606.ENSP00000425961 | Serine peptidase inhibitor, Kazal type 2 |
| DROSHA protein network | https://string-db.org/network/9606.ENSP00000425979 | Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex th [...] |
| C7orf73 protein network | https://string-db.org/network/9606.ENSP00000425996 | Short transmembrane mitochondrial protein 1; Chromosome 7 open reading frame 73 |
| GNGT2 protein network | https://string-db.org/network/9606.ENSP00000426022 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling s [...] |
| HELT protein network | https://string-db.org/network/9606.ENSP00000426033 | Hairy and enhancer of split-related protein HELT; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'; Belongs to the HEY family |
| C5orf28 protein network | https://string-db.org/network/9606.ENSP00000426067 | Transmembrane protein 267; Chromosome 5 open reading frame 28 |
| TRPC7 protein network | https://string-db.org/network/9606.ENSP00000426070 | Short transient receptor potential channel 7; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger s [...] |
| ADH1C protein network | https://string-db.org/network/9606.ENSP00000426083 | Alcohol dehydrogenase 1C, gamma polypeptide |
| MIB2 protein network | https://string-db.org/network/9606.ENSP00000426103 | E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notc [...] |
| CRIP2 protein network | https://string-db.org/network/9606.ENSP00000426119 | Cysteine rich protein 2; LIM domain containing |
| GRAMD3 protein network | https://string-db.org/network/9606.ENSP00000426120 | GRAM domain-containing protein 2B; GRAM domain containing 3 |
| C6orf223 protein network | https://string-db.org/network/9606.ENSP00000426159 | Uncharacterized protein C6orf223; Chromosome 6 open reading frame 223 |
| OSTC protein network | https://string-db.org/network/9606.ENSP00000426167 | Oligosaccharyltransferase complex subunit OSTC; May act as substrate-specific component of the N- oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosacc [...] |
| CCDC169 protein network | https://string-db.org/network/9606.ENSP00000426174 | Coiled-coil domain containing 169 |
| RAD17 protein network | https://string-db.org/network/9606.ENSP00000426191 | Cell cycle checkpoint protein RAD17; Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity [...] |
| SERINC5 protein network | https://string-db.org/network/9606.ENSP00000426237 | Serine incorporator 5; Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the vira [...] |
| SNX25 protein network | https://string-db.org/network/9606.ENSP00000426255 | Sorting nexin-25; May be involved in several stages of intracellular trafficking; Sorting nexins |
| ROPN1B protein network | https://string-db.org/network/9606.ENSP00000426271 | Ropporin-1B; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capaci [...] |
| MLIP protein network | https://string-db.org/network/9606.ENSP00000426290 | Muscular LMNA-interacting protein; Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a [...] |
| PCP4L1 protein network | https://string-db.org/network/9606.ENSP00000426296 | Purkinje cell protein 4 like 1; Belongs to the PCP4 family |
| TMEM161B protein network | https://string-db.org/network/9606.ENSP00000426354 | Transmembrane protein 161B; Belongs to the TMEM161 family |
| MCIDAS protein network | https://string-db.org/network/9606.ENSP00000426359 | Multicilin; Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required fo [...] |
| ZBTB38 protein network | https://string-db.org/network/9606.ENSP00000426387 | Zinc finger and BTB domain-containing protein 38; Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus seq [...] |
| ASTE1 protein network | https://string-db.org/network/9606.ENSP00000426421 | Protein asteroid homolog 1; Possible role in EGF receptor signaling |
| RNASET2 protein network | https://string-db.org/network/9606.ENSP00000426455 | Ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RN [...] |
| RNF4 protein network | https://string-db.org/network/9606.ENSP00000426503 | E3 ubiquitin-protein ligase RNF4; E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked pol [...] |
| AMER2 protein network | https://string-db.org/network/9606.ENSP00000426528 | APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphos [...] |
| KCTD16 protein network | https://string-db.org/network/9606.ENSP00000426548 | BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter [...] |
| SMAD1 protein network | https://string-db.org/network/9606.ENSP00000426568 | Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1 [...] |
| TNIP3 protein network | https://string-db.org/network/9606.ENSP00000426613 | TNFAIP3-interacting protein 3; Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetra [...] |
| ERBB2IP protein network | https://string-db.org/network/9606.ENSP00000426632 | Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state. Inhibits [...] |
| ETFDH protein network | https://string-db.org/network/9606.ENSP00000426638 | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone; Belongs to the ETF-QO/FixC family |
| WNT8A protein network | https://string-db.org/network/9606.ENSP00000426653 | Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, nota [...] |
| ANAPC4 protein network | https://string-db.org/network/9606.ENSP00000426654 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G [...] |
| GOLGA8K protein network | https://string-db.org/network/9606.ENSP00000426691 | Golgin A8 family member K; Belongs to the GOLGA8 family |
| ENSG00000251246 protein network | https://string-db.org/network/9606.ENSP00000426741 | Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3 ; Belongs to the ephrin family |
| PROM1 protein network | https://string-db.org/network/9606.ENSP00000426809 | Prominin-1; May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol- containing plasma membrane microdomains and may play a role in the organization [...] |
| ENSG00000249141 protein network | https://string-db.org/network/9606.ENSP00000426906 | Belongs to the RNase T2 family. |
| GNB2L1 protein network | https://string-db.org/network/9606.ENSP00000426909 | Receptor of activated protein C kinase 1; (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses; Belongs to the WD [...] |
| MRPS27 protein network | https://string-db.org/network/9606.ENSP00000426941 | 28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondria [...] |
| ENSG00000273217 protein network | https://string-db.org/network/9606.ENSP00000426948 | Uncharacterized protein |
| YJEFN3 protein network | https://string-db.org/network/9606.ENSP00000426964 | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis |
| NXF5 protein network | https://string-db.org/network/9606.ENSP00000426978 | Nuclear RNA export factor 5; Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neuro [...] |
| RPS6KA2 protein network | https://string-db.org/network/9606.ENSP00000427015 | Ribosomal protein S6 kinase alpha-2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of tran [...] |
| CDKN2AIP protein network | https://string-db.org/network/9606.ENSP00000427108 | CDKN2A-interacting protein; Regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence; Belongs to th [...] |
| FYB protein network | https://string-db.org/network/9606.ENSP00000427114 | FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents th [...] |
| KCNN2 protein network | https://string-db.org/network/9606.ENSP00000427120 | Small conductance calcium-activated potassium channel protein 2; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...] |
| RAI14 protein network | https://string-db.org/network/9606.ENSP00000427123 | Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhe [...] |
| ANKRD13D protein network | https://string-db.org/network/9606.ENSP00000427130 | Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regul [...] |
| APBB2 protein network | https://string-db.org/network/9606.ENSP00000427211 | Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein |
| MARCH1 protein network | https://string-db.org/network/9606.ENSP00000427223 | E3 ubiquitin-protein ligase MARCH1; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subseq [...] |
| USP17L20 protein network | https://string-db.org/network/9606.ENSP00000427264 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 20; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| CXCL2 protein network | https://string-db.org/network/9606.ENSP00000427279 | C-X-C motif chemokine 2; Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor c [...] |
| FOXR2 protein network | https://string-db.org/network/9606.ENSP00000427329 | Forkhead box R2 |
| DIO3 protein network | https://string-db.org/network/9606.ENSP00000427336 | Thyroxine 5-deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronin [...] |
| CT45A5 protein network | https://string-db.org/network/9606.ENSP00000427342 | Cancer/testis antigen family 45 member A5; Belongs to the CT45 family |
| USP17L26 protein network | https://string-db.org/network/9606.ENSP00000427366 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 24; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| SREK1IP1 protein network | https://string-db.org/network/9606.ENSP00000427401 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival |
| SMIM20 protein network | https://string-db.org/network/9606.ENSP00000427407 | Small integral membrane protein 20; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxida [...] |
| CDC42SE2 protein network | https://string-db.org/network/9606.ENSP00000427421 | CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape ch [...] |
| TNFAIP8 protein network | https://string-db.org/network/9606.ENSP00000427424 | Tumor necrosis factor alpha-induced protein 8; Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 act [...] |
| FAM218A protein network | https://string-db.org/network/9606.ENSP00000427428 | Protein FAM218A; Family with sequence similarity 218 member A |
| SPCS3 protein network | https://string-db.org/network/9606.ENSP00000427463 | Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated [...] |
| CEBPA protein network | https://string-db.org/network/9606.ENSP00000427514 | CCAAT/enhancer-binding protein alpha; Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and [...] |
| CEP192 protein network | https://string-db.org/network/9606.ENSP00000427550 | Centrosomal protein of 192 kDa; Required for mitotic centrosome and spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and cent [...] |
| DDR1 protein network | https://string-db.org/network/9606.ENSP00000427552 | Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remode [...] |
| LOC285556 protein network | https://string-db.org/network/9606.ENSP00000427555 | Protein LOC285556 |
| ABL2 protein network | https://string-db.org/network/9606.ENSP00000427562 | Abelson tyrosine-protein kinase 2; Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in [...] |
| FHDC1 protein network | https://string-db.org/network/9606.ENSP00000427567 | Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation . Regulates Golgi ribbon form [...] |
| SLC4A9 protein network | https://string-db.org/network/9606.ENSP00000427661 | Anion exchange protein 4; Probable apical anion exchanger of the kidney cortex; Belongs to the anion exchanger (TC 2.A.31) family |
| MTTP protein network | https://string-db.org/network/9606.ENSP00000427679 | Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of p [...] |
| FAM153B protein network | https://string-db.org/network/9606.ENSP00000427684 | Protein FAM153B; Family with sequence similarity 153 member B |
| WDR1 protein network | https://string-db.org/network/9606.ENSP00000427687 | WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Enhances cofilin-mediated actin severing (By similarity). Involved in cytok [...] |
| GYPB protein network | https://string-db.org/network/9606.ENSP00000427690 | Glycophorin-B; This protein is a minor sialoglycoprotein in erythrocyte membranes; Belongs to the glycophorin-A family |
| TOB1 protein network | https://string-db.org/network/9606.ENSP00000427695 | Protein Tob1; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CP [...] |
| WWC1 protein network | https://string-db.org/network/9606.ENSP00000427772 | Protein KIBRA; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting a [...] |
| WWP1 protein network | https://string-db.org/network/9606.ENSP00000427793 | NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...] |
| NACA2 protein network | https://string-db.org/network/9606.ENSP00000427802 | Nascent polypeptide-associated complex subunit alpha-2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as th [...] |
| C8orf34 protein network | https://string-db.org/network/9606.ENSP00000427820 | Uncharacterized protein C8orf34; Chromosome 8 open reading frame 34 |
| CEP57L1 protein network | https://string-db.org/network/9606.ENSP00000427844 | Centrosomal protein CEP57L1; Centrosomal protein which may be required for microtubule attachment to centrosomes; Belongs to the translokin family |
| DMTN protein network | https://string-db.org/network/9606.ENSP00000427866 | Dematin; Membrane-cytoskeleton-associated protein with F-actin- binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated up [...] |
| ANKAR protein network | https://string-db.org/network/9606.ENSP00000427882 | Ankyrin and armadillo repeat containing |
| HS3ST5 protein network | https://string-db.org/network/9606.ENSP00000427888 | Heparan sulfate glucosamine 3-O-sulfotransferase 5; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine res [...] |
| KIF13B protein network | https://string-db.org/network/9606.ENSP00000427900 | Kinesin-like protein KIF13B; Involved in reorganization of the cortical cytoskeleton. Regulates axon formation by promoting the formation of extra axons. May be functionally important for the int [...] |
| RHOBTB2 protein network | https://string-db.org/network/9606.ENSP00000427926 | Rho-related BTB domain-containing protein 2; Rho related BTB domain containing 2 |
| CCDC160 protein network | https://string-db.org/network/9606.ENSP00000427951 | Coiled-coil domain containing 160; Belongs to the CCDC160 family |
| RANBP17 protein network | https://string-db.org/network/9606.ENSP00000427975 | Ran-binding protein 17; May function as a nuclear transport receptor; Armadillo-like helical domain containing |
| C8orf44 protein network | https://string-db.org/network/9606.ENSP00000428002 | Putative uncharacterized protein C8orf44; Chromosome 8 open reading frame 44 |
| PIK3R1 protein network | https://string-db.org/network/9606.ENSP00000428056 | Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p [...] |
| RPL30 protein network | https://string-db.org/network/9606.ENSP00000428085 | Ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family |
| SLC45A4 protein network | https://string-db.org/network/9606.ENSP00000428137 | Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family |
| MPP2 protein network | https://string-db.org/network/9606.ENSP00000428182 | MAGUK p55 subfamily member 2; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons [...] |
| FBXO32 protein network | https://string-db.org/network/9606.ENSP00000428205 | F-box only protein 32; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degrada [...] |
| UBE2V2 protein network | https://string-db.org/network/9606.ENSP00000428209 | Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked [...] |
| IRGM protein network | https://string-db.org/network/9606.ENSP00000428220 | Immunity-related GTPase family M protein; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulat [...] |
| RPL26L1 protein network | https://string-db.org/network/9606.ENSP00000428223 | Ribosomal protein L26 like 1; Belongs to the universal ribosomal protein uL24 family |
| CETN3 protein network | https://string-db.org/network/9606.ENSP00000428259 | Centrin-3; EF-hand domain containing |
| C14orf159 protein network | https://string-db.org/network/9606.ENSP00000428263 | D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo- D-proline |
| FER1L6 protein network | https://string-db.org/network/9606.ENSP00000428280 | Fer-1-like protein 6; Fer-1 like family member 6 |
| LEPROTL1 protein network | https://string-db.org/network/9606.ENSP00000428281 | Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of redu [...] |
| PCDHGB4 protein network | https://string-db.org/network/9606.ENSP00000428288 | Protocadherin gamma-B4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| SERPINE3 protein network | https://string-db.org/network/9606.ENSP00000428316 | Serpin E3; Probable serine protease inhibitor; Serpin peptidase inhibitors |
| VASH2 protein network | https://string-db.org/network/9606.ENSP00000428324 | Vasohibin-2; Angiogenesis inhibitor. Inhibits network formation by endothelial cells; Belongs to the vasohibin family |
| PYDC2 protein network | https://string-db.org/network/9606.ENSP00000428325 | Pyrin domain-containing protein 2; May play a role in innate immunity by disrupting the interaction between PYCARD and NLRP3, thereby regulating the NLRP3 inflammasome. May also inhibit NF-kappa- [...] |
| SFTA3 protein network | https://string-db.org/network/9606.ENSP00000428331 | Surfactant-associated protein 3; Surfactant associated 3 |
| SPSB2 protein network | https://string-db.org/network/9606.ENSP00000428338 | SPRY domain-containing SOCS box protein 2; Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the u [...] |
| ANGPT1 protein network | https://string-db.org/network/9606.ENSP00000428340 | Angiopoietin-1; Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell surviv [...] |
| RGS21 protein network | https://string-db.org/network/9606.ENSP00000428343 | Regulator of G-protein signaling 21; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form; Regulators [...] |
| CLVS1 protein network | https://string-db.org/network/9606.ENSP00000428402 | Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) |
| RIMS1 protein network | https://string-db.org/network/9606.ENSP00000428417 | Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Ess [...] |
| TCEA1 protein network | https://string-db.org/network/9606.ENSP00000428426 | Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property [...] |
| DLX6 protein network | https://string-db.org/network/9606.ENSP00000428480 | Homeobox protein DLX-6; NKL subclass homeoboxes and pseudogenes |
| PBK protein network | https://string-db.org/network/9606.ENSP00000428489 | Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When pho [...] |
| GFRA2 protein network | https://string-db.org/network/9606.ENSP00000428518 | GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosin [...] |
| ST3GAL1 protein network | https://string-db.org/network/9606.ENSP00000428540 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr [...] |
| TMEM200B protein network | https://string-db.org/network/9606.ENSP00000428544 | Transmembrane protein 200B |
| SEC24B protein network | https://string-db.org/network/9606.ENSP00000428564 | Protein transport protein Sec24B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main fu [...] |
| LY6E protein network | https://string-db.org/network/9606.ENSP00000428572 | Lymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs ma [...] |
| NWD1 protein network | https://string-db.org/network/9606.ENSP00000428579 | NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels; WD repeat domain containing |
| SMIM12 protein network | https://string-db.org/network/9606.ENSP00000428585 | Small integral membrane protein 12 |
| PCDHGB6 protein network | https://string-db.org/network/9606.ENSP00000428603 | Protocadherin gamma-B6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| SLC10A5 protein network | https://string-db.org/network/9606.ENSP00000428612 | Sodium/bile acid cotransporter 5; Solute carrier family 10 member 5 |
| UTP14C protein network | https://string-db.org/network/9606.ENSP00000428619 | U3 small nucleolar RNA-associated protein 14 homolog C; Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis (By sim [...] |
| FBXO41 protein network | https://string-db.org/network/9606.ENSP00000428646 | F-box only protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-boxes other |
| NAIP protein network | https://string-db.org/network/9606.ENSP00000428657 | Baculoviral IAP repeat-containing protein 1; Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pr [...] |
| ZNF829 protein network | https://string-db.org/network/9606.ENSP00000428679 | Zinc finger protein 829; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RNF217 protein network | https://string-db.org/network/9606.ENSP00000428698 | Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the u [...] |
| STAU2 protein network | https://string-db.org/network/9606.ENSP00000428756 | Double-stranded RNA-binding protein Staufen homolog 2; RNA-binding protein required for the microtubule- dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthes [...] |
| CLDN23 protein network | https://string-db.org/network/9606.ENSP00000428780 | Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| AP3M2 protein network | https://string-db.org/network/9606.ENSP00000428787 | AP-3 complex subunit mu-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral struct [...] |
| VDAC3 protein network | https://string-db.org/network/9606.ENSP00000428845 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitoc [...] |
| CES5A protein network | https://string-db.org/network/9606.ENSP00000428864 | Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Carboxylesterases |
| FAM83A protein network | https://string-db.org/network/9606.ENSP00000428876 | Protein FAM83A; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both RAS/MAPK and PI3K/AKT/TOR signaling cascades downstream of EG [...] |
| ZNF721 protein network | https://string-db.org/network/9606.ENSP00000428878 | Zinc finger protein 721; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| COX6C protein network | https://string-db.org/network/9606.ENSP00000428895 | Cytochrome c oxidase subunit 6C; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport |
| LYN protein network | https://string-db.org/network/9606.ENSP00000428924 | Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune re [...] |
| ENSG00000264668 protein network | https://string-db.org/network/9606.ENSP00000428966 | Zinc finger protein 41 homolog; A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis; Zinc fingers C2H2-type |
| RNF19A protein network | https://string-db.org/network/9606.ENSP00000428968 | E3 ubiquitin-protein ligase RNF19A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transf [...] |
| CCNC protein network | https://string-db.org/network/9606.ENSP00000428982 | Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey infor [...] |
| GRIA1 protein network | https://string-db.org/network/9606.ENSP00000428994 | Glutamate receptor 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter [...] |
| ANKRD46 protein network | https://string-db.org/network/9606.ENSP00000429015 | Ankyrin repeat domain-containing protein 46; Ankyrin repeat domain containing |
| PCDHGB2 protein network | https://string-db.org/network/9606.ENSP00000429018 | Protocadherin gamma-B2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| ENSG00000270024 protein network | https://string-db.org/network/9606.ENSP00000429022 | annotation not available |
| INTS9 protein network | https://string-db.org/network/9606.ENSP00000429065 | Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| NKAIN3 protein network | https://string-db.org/network/9606.ENSP00000429073 | Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Sodium/potassium transporting ATPase interacting 3; Belongs to the NKAIN family |
| UBR5 protein network | https://string-db.org/network/9606.ENSP00000429084 | E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destab [...] |
| CCNE2 protein network | https://string-db.org/network/9606.ENSP00000429089 | G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase; Belongs to the cyclin family. Cyclin E subfamily |
| ZNF674 protein network | https://string-db.org/network/9606.ENSP00000429148 | Zinc finger protein 674; May be involved in transcriptional regulation; X-linked mental retardation |
| FAM49B protein network | https://string-db.org/network/9606.ENSP00000429150 | Protein FAM49B; Family with sequence similarity 49 member B |
| SLC25A30 protein network | https://string-db.org/network/9606.ENSP00000429168 | Kidney mitochondrial carrier protein 1; Probable transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| ENDOV protein network | https://string-db.org/network/9606.ENSP00000429190 | Endonuclease V; Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (s [...] |
| SLC25A37 protein network | https://string-db.org/network/9606.ENSP00000429200 | Mitoferrin-1; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into [...] |
| TRNP1 protein network | https://string-db.org/network/9606.ENSP00000429216 | TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Re [...] |
| ENSG00000248405 protein network | https://string-db.org/network/9606.ENSP00000429240 | annotation not available |
| STMN2 protein network | https://string-db.org/network/9606.ENSP00000429243 | Stathmin-2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negati [...] |
| PCDHGB1 protein network | https://string-db.org/network/9606.ENSP00000429273 | Protocadherin gamma-B1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| TMEM125 protein network | https://string-db.org/network/9606.ENSP00000429275 | Transmembrane protein 125 |
| PGRMC2 protein network | https://string-db.org/network/9606.ENSP00000429301 | Membrane-associated progesterone receptor component 2; Receptor for steroids; Membrane associated progesterone receptor family |
| TPD52 protein network | https://string-db.org/network/9606.ENSP00000429309 | Belongs to the TPD52 family |
| PNMA2 protein network | https://string-db.org/network/9606.ENSP00000429344 | Paraneoplastic Ma antigens; Belongs to the PNMA family |
| FAM92A1 protein network | https://string-db.org/network/9606.ENSP00000429367 | Protein FAM92A; May play a role in ciliogenesis. In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendages during early [...] |
| RPS20 protein network | https://string-db.org/network/9606.ENSP00000429374 | Ribosomal protein S20 |
| TENM2 protein network | https://string-db.org/network/9606.ENSP00000429430 | Teneurin-2; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal [...] |
| HS6ST2 protein network | https://string-db.org/network/9606.ENSP00000429473 | Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine resi [...] |
| TRIQK protein network | https://string-db.org/network/9606.ENSP00000429517 | Triple QxxK/R motif-containing protein; May play a role in cell growth and maintenance of cell morphology |
| NKX6-3 protein network | https://string-db.org/network/9606.ENSP00000429553 | Homeobox protein Nkx-6.3; Putative transcription factor, which may be involved in patterning of central nervous system and pancreas; NKL subclass homeoboxes and pseudogenes |
| UNC13A protein network | https://string-db.org/network/9606.ENSP00000429562 | Protein unc-13 homolog A; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synapt [...] |
| PCDHGA6 protein network | https://string-db.org/network/9606.ENSP00000429601 | Protocadherin gamma-A6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| FANCD2OS protein network | https://string-db.org/network/9606.ENSP00000429608 | FANCD2 opposite strand |
| ERI1 protein network | https://string-db.org/network/9606.ENSP00000429615 | 3'-5' exoribonuclease 1; RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and [...] |
| MYBL1 protein network | https://string-db.org/network/9606.ENSP00000429633 | Myb-related protein A; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expr [...] |
| ATP6V0E1 protein network | https://string-db.org/network/9606.ENSP00000429690 | V-type proton ATPase subunit e 1; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the V-ATPase e1/e2 subunit family |
| FAM159A protein network | https://string-db.org/network/9606.ENSP00000429726 | Membrane protein FAM159A; Family with sequence similarity 159, member A; Belongs to the FAM159 family |
| STK3 protein network | https://string-db.org/network/9606.ENSP00000429744 | Serine/threonine-protein kinase 3; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA [...] |
| FAM196A protein network | https://string-db.org/network/9606.ENSP00000429763 | Protein FAM196A; Family with sequence similarity 196 member A |
| ZNF260 protein network | https://string-db.org/network/9606.ENSP00000429803 | Zinc finger protein 260; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of gene [...] |
| PCDHA3 protein network | https://string-db.org/network/9606.ENSP00000429808 | Protocadherin alpha-3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| CLINT1 protein network | https://string-db.org/network/9606.ENSP00000429824 | Clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi networ [...] |
| PCDHGA5 protein network | https://string-db.org/network/9606.ENSP00000429834 | Protocadherin gamma-A5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| SNTG1 protein network | https://string-db.org/network/9606.ENSP00000429842 | Gamma-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystro [...] |
| TVP23C-CDRT4 protein network | https://string-db.org/network/9606.ENSP00000429865 | Golgi apparatus membrane protein TVP23 homolog; TVP23C-CDRT4 readthrough |
| FAM178B protein network | https://string-db.org/network/9606.ENSP00000429896 | Protein FAM178B; Family with sequence similarity 178 member B |
| ASAP1 protein network | https://string-db.org/network/9606.ENSP00000429900 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; Possesses phosphatidylinositol 4,5-bisphosphate- dependent GTPase-activating protein activity for ARF1 (ADP ribosylation fa [...] |
| EIF3H protein network | https://string-db.org/network/9606.ENSP00000429931 | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| SCUBE2 protein network | https://string-db.org/network/9606.ENSP00000429969 | Signal peptide, CUB domain and EGF like domain containing 2 |
| ENY2 protein network | https://string-db.org/network/9606.ENSP00000429986 | Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histon [...] |
| ATXN7L3B protein network | https://string-db.org/network/9606.ENSP00000430000 | Ataxin-7-like protein 3B; By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone d [...] |
| PCDHGA7 protein network | https://string-db.org/network/9606.ENSP00000430024 | Protocadherin gamma-A7; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| LYRM2 protein network | https://string-db.org/network/9606.ENSP00000430025 | LYR motif containing 2 |
| CNBD1 protein network | https://string-db.org/network/9606.ENSP00000430073 | Cyclic nucleotide-binding domain-containing protein 1; Cyclic nucleotide binding domain containing 1 |
| AMPD1 protein network | https://string-db.org/network/9606.ENSP00000430075 | AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family |
| GABRP protein network | https://string-db.org/network/9606.ENSP00000430100 | Gamma-aminobutyric acid receptor subunit pi; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and o [...] |
| RALYL protein network | https://string-db.org/network/9606.ENSP00000430128 | RNA-binding Raly-like protein; RALY RNA binding protein like |
| ALG11 protein network | https://string-db.org/network/9606.ENSP00000430236 | GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic [...] |
| RNF130 protein network | https://string-db.org/network/9606.ENSP00000430237 | E3 ubiquitin-protein ligase RNF130; May have a role during the programmed cell death of hematopoietic cells (By similarity). Acts as an E3 ubiquitin- protein ligase; Ring finger proteins |
| EBF2 protein network | https://string-db.org/network/9606.ENSP00000430241 | Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with t [...] |
| SBSN protein network | https://string-db.org/network/9606.ENSP00000430242 | Suprabasin |
| EPHX2 protein network | https://string-db.org/network/9606.ENSP00000430269 | Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobi [...] |
| ETV3L protein network | https://string-db.org/network/9606.ENSP00000430271 | ETS translocation variant 3-like protein; Transcriptional regulator; ETS transcription factor family |
| MCF2 protein network | https://string-db.org/network/9606.ENSP00000430276 | Proto-oncogene DBL; Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GT [...] |
| PRSS46 protein network | https://string-db.org/network/9606.ENSP00000430307 | Protease, serine, 46; Belongs to the peptidase S1 family |
| TDRP protein network | https://string-db.org/network/9606.ENSP00000430325 | Contributes to normal sperm motility, but not essential for male fertility |
| INTS8 protein network | https://string-db.org/network/9606.ENSP00000430338 | Integrator complex subunit 8; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integ [...] |
| PLCD1 protein network | https://string-db.org/network/9606.ENSP00000430344 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by acti [...] |
| HDAC2 protein network | https://string-db.org/network/9606.ENSP00000430432 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic rep [...] |
| CNOT8 protein network | https://string-db.org/network/9606.ENSP00000430493 | CCR4-NOT transcription complex subunit 8; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalyti [...] |
| UQCRB protein network | https://string-db.org/network/9606.ENSP00000430494 | Cytochrome b-c1 complex subunit 7; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory cha [...] |
| ZFHX4 protein network | https://string-db.org/network/9606.ENSP00000430497 | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes |
| PTDSS1 protein network | https://string-db.org/network/9606.ENSP00000430548 | Phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, [...] |
| ATOX1 protein network | https://string-db.org/network/9606.ENSP00000430598 | Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense; Belongs to the ATX1 family |
| HEPH protein network | https://string-db.org/network/9606.ENSP00000430620 | Hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate i [...] |
| CA1 protein network | https://string-db.org/network/9606.ENSP00000430656 | Carbonic anhydrase 1; Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea; Carbonic anhydrases |
| KCNK9 protein network | https://string-db.org/network/9606.ENSP00000430676 | Potassium channel subfamily K member 9; pH-dependent, voltage-insensitive, background potassium channel protein; Potassium two pore domain channel subfamily K |
| IKBKB protein network | https://string-db.org/network/9606.ENSP00000430684 | Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammator [...] |
| TFF3 protein network | https://string-db.org/network/9606.ENSP00000430690 | Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen) |
| EIF5AL1 protein network | https://string-db.org/network/9606.ENSP00000430706 | Eukaryotic translation initiation factor 5A-1-like; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of [...] |
| TRHR protein network | https://string-db.org/network/9606.ENSP00000430711 | Thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; [...] |
| CSMD1 protein network | https://string-db.org/network/9606.ENSP00000430733 | CUB and sushi domain-containing protein 1; Potential suppressor of squamous cell carcinomas; Protein phosphatase 1 regulatory subunits |
| ENSG00000272772 protein network | https://string-db.org/network/9606.ENSP00000430774 | Uncharacterized protein; Belongs to the SKP1 family |
| ZNF706 protein network | https://string-db.org/network/9606.ENSP00000430823 | Zinc finger protein 706; Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4 |
| KCNB2 protein network | https://string-db.org/network/9606.ENSP00000430846 | Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth mus [...] |
| NPIPB11 protein network | https://string-db.org/network/9606.ENSP00000430853 | Nuclear pore complex interacting protein family member B11 |
| GPBAR1 protein network | https://string-db.org/network/9606.ENSP00000430886 | G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP productio [...] |
| CCDC71L protein network | https://string-db.org/network/9606.ENSP00000430897 | Coiled-coil domain-containing protein 71L; Coiled-coil domain containing 71 like |
| C1orf210 protein network | https://string-db.org/network/9606.ENSP00000430918 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane |
| HMGB4 protein network | https://string-db.org/network/9606.ENSP00000430919 | Canonical high mobility group; Belongs to the HMGB family |
| BAI1 protein network | https://string-db.org/network/9606.ENSP00000430945 | Adhesion G protein-coupled receptor B1; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulate [...] |
| IDO1 protein network | https://string-db.org/network/9606.ENSP00000430950 | Indoleamine 2,3-dioxygenase 1; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune [...] |
| RNF145 protein network | https://string-db.org/network/9606.ENSP00000430955 | E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phag [...] |
| ANKRD6 protein network | https://string-db.org/network/9606.ENSP00000430985 | Ankyrin repeat domain-containing protein 6; Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-c [...] |
| MRPL22 protein network | https://string-db.org/network/9606.ENSP00000431040 | Mitochondrial ribosomal protein L22 |
| GSTK1 protein network | https://string-db.org/network/9606.ENSP00000431049 | Soluble glutathione S-transferases |
| PCDHGA1 protein network | https://string-db.org/network/9606.ENSP00000431083 | Protocadherin gamma-A1; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| CTRP5 protein network | https://string-db.org/network/9606.ENSP00000431140 | Complement C1q tumor necrosis factor-related protein 5; C1q and TNF related 5 |
| EID1 protein network | https://string-db.org/network/9606.ENSP00000431162 | EP300-interacting inhibitor of differentiation 1; Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be [...] |
| ENSG00000258472 protein network | https://string-db.org/network/9606.ENSP00000431165 | Uncharacterized protein |
| BTBD10 protein network | https://string-db.org/network/9606.ENSP00000431186 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in pre [...] |
| ZNF345 protein network | https://string-db.org/network/9606.ENSP00000431202 | Zinc finger protein 345; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IGLL5 protein network | https://string-db.org/network/9606.ENSP00000431254 | Immunoglobulin lambda like polypeptide 5; C1-set domain containing |
| ZFP82 protein network | https://string-db.org/network/9606.ENSP00000431265 | Zinc finger protein 82 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LPXN protein network | https://string-db.org/network/9606.ENSP00000431284 | Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negati [...] |
| METTL12 protein network | https://string-db.org/network/9606.ENSP00000431287 | Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive [...] |
| TATDN3 protein network | https://string-db.org/network/9606.ENSP00000431376 | Putative deoxyribonuclease TATDN3; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family |
| API5 protein network | https://string-db.org/network/9606.ENSP00000431391 | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated D [...] |
| PGBD5 protein network | https://string-db.org/network/9606.ENSP00000431404 | PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements. Can induce genomic rearrangements that inactivate the HPRT1 gene; DNA transpos [...] |
| NTRK1 protein network | https://string-db.org/network/9606.ENSP00000431418 | High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferati [...] |
| KRTAP5-9 protein network | https://string-db.org/network/9606.ENSP00000431443 | Keratin-associated protein 5-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which ar [...] |
| CD3G protein network | https://string-db.org/network/9606.ENSP00000431445 | T-cell surface glycoprotein CD3 gamma chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cel [...] |
| FAM89B protein network | https://string-db.org/network/9606.ENSP00000431459 | Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TG [...] |
| NEDD8-MDP1 protein network | https://string-db.org/network/9606.ENSP00000431482 | NEDD8-MDP1 readthrough |
| HSF1 protein network | https://string-db.org/network/9606.ENSP00000431512 | Heat shock factor protein 1; Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), lead [...] |
| POU2F2 protein network | https://string-db.org/network/9606.ENSP00000431603 | POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to acti [...] |
| MS4A18 protein network | https://string-db.org/network/9606.ENSP00000431607 | Membrane spanning 4-domains A18 |
| TAS2R43 protein network | https://string-db.org/network/9606.ENSP00000431719 | Taste receptor type 2 member 43; Gustducin-coupled receptor immplicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calc [...] |
| PCDHA2 protein network | https://string-db.org/network/9606.ENSP00000431748 | Protocadherin alpha-2; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| C12orf55 protein network | https://string-db.org/network/9606.ENSP00000431759 | Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella |
| EIF3F protein network | https://string-db.org/network/9606.ENSP00000431800 | Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| AAMDC protein network | https://string-db.org/network/9606.ENSP00000431808 | Mth938 domain-containing protein; May play a role in preadipocyte differentiation and adipogenesis; Belongs to the AAMDC family |
| CSRP3 protein network | https://string-db.org/network/9606.ENSP00000431813 | Cysteine and glycine-rich protein 3; Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding [...] |
| SLC24A4 protein network | https://string-db.org/network/9606.ENSP00000431840 | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neur [...] |
| NPIPB6 protein network | https://string-db.org/network/9606.ENSP00000431871 | Nuclear pore complex interacting protein family member B6; Belongs to the NPIP family |
| USP35 protein network | https://string-db.org/network/9606.ENSP00000431876 | Ubiquitin specific peptidase 35 |
| TYK2 protein network | https://string-db.org/network/9606.ENSP00000431885 | Non-receptor tyrosine-protein kinase TYK2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/ [...] |
| OR10S1 protein network | https://string-db.org/network/9606.ENSP00000431914 | Olfactory receptor 10S1; Odorant receptor; Olfactory receptors, family 10 |
| AMBRA1 protein network | https://string-db.org/network/9606.ENSP00000431926 | Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal develo [...] |
| L3MBTL3 protein network | https://string-db.org/network/9606.ENSP00000431962 | Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromat [...] |
| SAMD1 protein network | https://string-db.org/network/9606.ENSP00000431971 | Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall; Sterile alpha motif domain containing |
| CAPN1 protein network | https://string-db.org/network/9606.ENSP00000431984 | Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction; Belongs [...] |
| OR52B2 protein network | https://string-db.org/network/9606.ENSP00000432011 | Olfactory receptor 52B2; Odorant receptor; Olfactory receptors, family 52 |
| ANKHD1-EIF4EBP3 protein network | https://string-db.org/network/9606.ENSP00000432016 | ANKHD1-EIF4EBP3 readthrough |
| HSPA8 protein network | https://string-db.org/network/9606.ENSP00000432083 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthes [...] |
| EBLN2 protein network | https://string-db.org/network/9606.ENSP00000432104 | Endogenous Bornavirus-like nucleoprotein 2; May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligome [...] |
| WDR74 protein network | https://string-db.org/network/9606.ENSP00000432119 | WD repeat-containing protein 74; WD repeat domain containing |
| CCDC17 protein network | https://string-db.org/network/9606.ENSP00000432172 | Coiled-coil domain containing 17 |
| IL32 protein network | https://string-db.org/network/9606.ENSP00000432218 | Interleukin-32; Interleukin 32; Interleukins |
| CHMP1B protein network | https://string-db.org/network/9606.ENSP00000432279 | Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodi [...] |
| TAGLN protein network | https://string-db.org/network/9606.ENSP00000432282 | Transgelin; Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence; Belongs to [...] |
| SPA17 protein network | https://string-db.org/network/9606.ENSP00000432305 | Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohyd [...] |
| ATG13 protein network | https://string-db.org/network/9606.ENSP00000432412 | Autophagy-related protein 13; Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the p [...] |
| OR5M11 protein network | https://string-db.org/network/9606.ENSP00000432417 | Olfactory receptor 5M11; Odorant receptor; Olfactory receptors, family 5 |
| GPR61 protein network | https://string-db.org/network/9606.ENSP00000432456 | Probable G-protein coupled receptor 61; Orphan receptor; Belongs to the G-protein coupled receptor 1 family |
| TMEM262 protein network | https://string-db.org/network/9606.ENSP00000432459 | Transmembrane protein 262 |
| BRK1 protein network | https://string-db.org/network/9606.ENSP00000432472 | Protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF- NTRK2 [...] |
| NAALAD2 protein network | https://string-db.org/network/9606.ENSP00000432481 | N-acetylated-alpha-linked acidic dipeptidase 2; Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptid [...] |
| SAAL1 protein network | https://string-db.org/network/9606.ENSP00000432487 | Protein SAAL1; Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli; Armadillo-like helical domain containing |
| C11orf98 protein network | https://string-db.org/network/9606.ENSP00000432523 | Uncharacterized protein LOC102288414 |
| HTN3 protein network | https://string-db.org/network/9606.ENSP00000432561 | Histatin-3; Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibi [...] |
| SPTBN2 protein network | https://string-db.org/network/9606.ENSP00000432568 | Spectrin beta chain, non-erythrocytic 2; Probably plays an important role in neuronal membrane skeleton; Belongs to the spectrin family |
| FAT3 protein network | https://string-db.org/network/9606.ENSP00000432586 | Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development; Cadherin related |
| NDUFC2-KCTD14 protein network | https://string-db.org/network/9606.ENSP00000432614 | NADH dehydrogenase [ubiquinone] 1 subunit C2, isoform 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in c [...] |
| YPEL4 protein network | https://string-db.org/network/9606.ENSP00000432648 | Protein yippee-like 4; Yippee like family; Belongs to the yippee family |
| SMTNL1 protein network | https://string-db.org/network/9606.ENSP00000432651 | Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylati [...] |
| CFL1 protein network | https://string-db.org/network/9606.ENSP00000432660 | Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. [...] |
| PIGY protein network | https://string-db.org/network/9606.ENSP00000432688 | Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y; Component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc [...] |
| UQCC3 protein network | https://string-db.org/network/9606.ENSP00000432692 | Ubiquinol-cytochrome-c reductase complex assembly factor 3; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...] |
| KIAA1456 protein network | https://string-db.org/network/9606.ENSP00000432695 | Probable tRNA methyltransferase 9-like protein; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 |
| TP53AIP1 protein network | https://string-db.org/network/9606.ENSP00000432743 | P53-regulated apoptosis-inducing protein 1; May play an important role in mediating p53/TP53- dependent apoptosis |
| CKAP5 protein network | https://string-db.org/network/9606.ENSP00000432768 | Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytop [...] |
| EYA4 protein network | https://string-db.org/network/9606.ENSP00000432770 | Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair [...] |
| KDM2A protein network | https://string-db.org/network/9606.ENSP00000432786 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylate [...] |
| MANF protein network | https://string-db.org/network/9606.ENSP00000432799 | Mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neuro [...] |
| ACRV1 protein network | https://string-db.org/network/9606.ENSP00000432816 | Acrosomal vesicle protein 1 |
| MEX3A protein network | https://string-db.org/network/9606.ENSP00000432845 | RNA-binding protein MEX3A; RNA binding protein, may be involved in post- transcriptional regulatory mechanisms; Ring finger proteins |
| GYLTL1B protein network | https://string-db.org/network/9606.ENSP00000432869 | LARGE xylosyl- and glucuronyltransferase 2; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phospho [...] |
| RNPC3 protein network | https://string-db.org/network/9606.ENSP00000432886 | RNA-binding protein 40; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-codi [...] |
| MPZ protein network | https://string-db.org/network/9606.ENSP00000432943 | Myelin protein P0; Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compa [...] |
| RGS5 protein network | https://string-db.org/network/9606.ENSP00000433001 | Regulator of G-protein signaling 5; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G( [...] |
| RBM4B protein network | https://string-db.org/network/9606.ENSP00000433071 | RNA-binding protein 4B; Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA (By similarity); RNA binding motif con [...] |
| TRIM3 protein network | https://string-db.org/network/9606.ENSP00000433102 | Tripartite motif-containing protein 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recyc [...] |
| KCNA2 protein network | https://string-db.org/network/9606.ENSP00000433109 | Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the centra [...] |
| TMEM41B protein network | https://string-db.org/network/9606.ENSP00000433126 | Transmembrane protein 41B; Required for normal motor neuron development |
| CASP1 protein network | https://string-db.org/network/9606.ENSP00000433138 | Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against p [...] |
| USP47 protein network | https://string-db.org/network/9606.ENSP00000433146 | Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in ba [...] |
| BBIP1 protein network | https://string-db.org/network/9606.ENSP00000433157 | BBSome interacting protein 1; Bardet-Biedl syndrome associated; BBSome |
| C11orf30 protein network | https://string-db.org/network/9606.ENSP00000433205 | BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the [...] |
| GSDMD protein network | https://string-db.org/network/9606.ENSP00000433209 | Gasdermin-D; Gasdermin-D, N-terminal: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in [...] |
| MS4A1 protein network | https://string-db.org/network/9606.ENSP00000433277 | B-lymphocyte antigen CD20; This protein may be involved in the regulation of B-cell activation and proliferation; Belongs to the MS4A family |
| SLC22A18AS protein network | https://string-db.org/network/9606.ENSP00000433282 | Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene B protein; Solute carrier family 22 member 18 antisense |
| KCNJ5 protein network | https://string-db.org/network/9606.ENSP00000433295 | G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow [...] |
| FAM118B protein network | https://string-db.org/network/9606.ENSP00000433343 | Protein FAM118B; May play a role in Cajal bodies formation; Belongs to the FAM118 family |
| LMO7 protein network | https://string-db.org/network/9606.ENSP00000433352 | LIM domain only protein 7; LIM domain containing |
| TMEM9B protein network | https://string-db.org/network/9606.ENSP00000433361 | Transmembrane protein 9B; Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways; Belongs to [...] |
| PCDHA6 protein network | https://string-db.org/network/9606.ENSP00000433378 | Protocadherin alpha-6; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| NT5C1B-RDH14 protein network | https://string-db.org/network/9606.ENSP00000433415 | NT5C1B-RDH14 readthrough |
| ARL15 protein network | https://string-db.org/network/9606.ENSP00000433427 | ADP-ribosylation factor-like protein 15; ADP ribosylation factor like GTPase 15; ARF GTPase family |
| MAGEL2 protein network | https://string-db.org/network/9606.ENSP00000433433 | MAGE-like protein 2; Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-con [...] |
| CREBZF protein network | https://string-db.org/network/9606.ENSP00000433459 | CREB/ATF bZIP transcription factor; Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. A [...] |
| FLI1 protein network | https://string-db.org/network/9606.ENSP00000433488 | Friend leukemia integration 1 transcription factor; Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'; Belongs to the ETS family |
| CALCB protein network | https://string-db.org/network/9606.ENSP00000433490 | Calcitonin gene-related peptide 2; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points towar [...] |
| GRK6 protein network | https://string-db.org/network/9606.ENSP00000433511 | G protein-coupled receptor kinase 6; Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desens [...] |
| ST5 protein network | https://string-db.org/network/9606.ENSP00000433528 | Suppression of tumorigenicity 5 protein; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab protei [...] |
| CRYAB protein network | https://string-db.org/network/9606.ENSP00000433560 | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress [...] |
| NPIPA5 protein network | https://string-db.org/network/9606.ENSP00000433597 | Nuclear pore complex interacting protein family member A5 |
| TRAF6 protein network | https://string-db.org/network/9606.ENSP00000433623 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, I [...] |
| FCGR3B protein network | https://string-db.org/network/9606.ENSP00000433642 | Low affinity immunoglobulin gamma Fc region receptor III-B; Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. C [...] |
| C10orf113 protein network | https://string-db.org/network/9606.ENSP00000433646 | Putative uncharacterized protein C10orf113; Chromosome 10 open reading frame 113 |
| EIF4G2 protein network | https://string-db.org/network/9606.ENSP00000433664 | Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by [...] |
| NCAPD3 protein network | https://string-db.org/network/9606.ENSP00000433681 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid ax [...] |
| SPRN protein network | https://string-db.org/network/9606.ENSP00000433712 | Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity) |
| TTC12 protein network | https://string-db.org/network/9606.ENSP00000433757 | Tetratricopeptide repeat domain containing |
| MS4A14 protein network | https://string-db.org/network/9606.ENSP00000433761 | Membrane-spanning 4-domains subfamily A member 14; May be involved in signal transduction as a component of a multimeric receptor complex; Membrane spanning 4-domains |
| ZNF585B protein network | https://string-db.org/network/9606.ENSP00000433773 | Zinc finger protein 585B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TSPAN19 protein network | https://string-db.org/network/9606.ENSP00000433816 | Putative tetraspanin-19; Tetraspanin 19; Tetraspanins |
| B3GAT1 protein network | https://string-db.org/network/9606.ENSP00000433847 | Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan bios [...] |
| CLNS1A protein network | https://string-db.org/network/9606.ENSP00000433919 | Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, play [...] |
| PNLIPRP1 protein network | https://string-db.org/network/9606.ENSP00000433933 | Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholin [...] |
| ENSG00000100926 protein network | https://string-db.org/network/9606.ENSP00000433967 | Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family |
| RNH1 protein network | https://string-db.org/network/9606.ENSP00000433999 | Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis |
| H2AFX protein network | https://string-db.org/network/9606.ENSP00000434024 | Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineri [...] |
| RAP1GAP protein network | https://string-db.org/network/9606.ENSP00000434033 | Rap1 GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state |
| FZD4 protein network | https://string-db.org/network/9606.ENSP00000434034 | Frizzled-4; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhib [...] |
| GPR68 protein network | https://string-db.org/network/9606.ENSP00000434045 | Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. M [...] |
| TPD52L1 protein network | https://string-db.org/network/9606.ENSP00000434142 | Tumor protein D52 like 1 |
| KCNC3 protein network | https://string-db.org/network/9606.ENSP00000434241 | Potassium voltage-gated channel subfamily C member 3; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in r [...] |
| TMPRSS13 protein network | https://string-db.org/network/9606.ENSP00000434279 | Transmembrane protease serine 13; Scavenger receptor cysteine rich domain containing; Belongs to the peptidase S1 family |
| CYB5RL protein network | https://string-db.org/network/9606.ENSP00000434343 | NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methem [...] |
| PUF60 protein network | https://string-db.org/network/9606.ENSP00000434359 | Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with F [...] |
| SLC6A5 protein network | https://string-db.org/network/9606.ENSP00000434364 | Sodium- and chloride-dependent glycine transporter 2; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termin [...] |
| NPIPB8 protein network | https://string-db.org/network/9606.ENSP00000434399 | Nuclear pore complex interacting protein family member B8; Belongs to the NPIP family |
| SERPINH1 protein network | https://string-db.org/network/9606.ENSP00000434412 | Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen; Serpin peptidase inhibitors |
| FAM111A protein network | https://string-db.org/network/9606.ENSP00000434435 | Protein FAM111A; Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis. May directly function at replication forks, explaining why [...] |
| ARFGAP2 protein network | https://string-db.org/network/9606.ENSP00000434442 | ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi comp [...] |
| INTS4 protein network | https://string-db.org/network/9606.ENSP00000434466 | Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The [...] |
| ACER3 protein network | https://string-db.org/network/9606.ENSP00000434480 | Alkaline ceramidase 3; Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity; Alkaline ceramidases |
| ENSG00000254469 protein network | https://string-db.org/network/9606.ENSP00000434508 | Putative short transient receptor potential channel 2-like protein ; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily |
| SLC43A3 protein network | https://string-db.org/network/9606.ENSP00000434515 | Solute carrier family 43 member 3; Putative transporter; Belongs to the SLC43A transporter (TC 2.A.1.44) family |
| TXNRD1 protein network | https://string-db.org/network/9606.ENSP00000434516 | Thioredoxin reductase 1, cytoplasmic; Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of c [...] |
| MAML2 protein network | https://string-db.org/network/9606.ENSP00000434552 | Mastermind-like protein 2; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 mor [...] |
| SOGA3 protein network | https://string-db.org/network/9606.ENSP00000434570 | SOGA family member 3 |
| C6orf141 protein network | https://string-db.org/network/9606.ENSP00000434602 | Uncharacterized protein C6orf141; Chromosome 6 open reading frame 141 |
| CDC27 protein network | https://string-db.org/network/9606.ENSP00000434614 | Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| PCDHA8 protein network | https://string-db.org/network/9606.ENSP00000434655 | Protocadherin alpha-8; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| USP50 protein network | https://string-db.org/network/9606.ENSP00000434676 | Inactive ubiquitin carboxyl-terminal hydrolase 50; Has no peptidase activity; Ubiquitin specific peptidases |
| CCDC90B protein network | https://string-db.org/network/9606.ENSP00000434724 | Coiled-coil domain-containing protein 90B, mitochondrial; Coiled-coil domain containing 90B |
| CCDC180 protein network | https://string-db.org/network/9606.ENSP00000434727 | Coiled-coil domain containing 180 |
| ATP6V0B protein network | https://string-db.org/network/9606.ENSP00000434729 | V-type proton ATPase 21 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of [...] |
| NRK protein network | https://string-db.org/network/9606.ENSP00000434830 | Nik-related protein kinase; May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling [...] |
| TSKU protein network | https://string-db.org/network/9606.ENSP00000434847 | Tsukushin; Tsukushi, small leucine rich proteoglycan |
| LRRC24 protein network | https://string-db.org/network/9606.ENSP00000434849 | Leucine-rich repeat-containing protein 24; Leucine rich repeat containing 24; I-set domain containing |
| THNSL1 protein network | https://string-db.org/network/9606.ENSP00000434887 | Threonine synthase like 1 |
| CLP1 protein network | https://string-db.org/network/9606.ENSP00000434995 | Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'- hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA ( [...] |
| DEFB134 protein network | https://string-db.org/network/9606.ENSP00000435010 | Beta-defensin 134; Has antibacterial activity; Defensins, beta |
| RPS25 protein network | https://string-db.org/network/9606.ENSP00000435096 | Ribosomal protein S25 |
| KIAA0408 protein network | https://string-db.org/network/9606.ENSP00000435150 | Uncharacterized protein KIAA0408; KIAA0408 |
| RAB30 protein network | https://string-db.org/network/9606.ENSP00000435189 | Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| BCLAF1 protein network | https://string-db.org/network/9606.ENSP00000435210 | Bcl-2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'en [...] |
| TEAD1 protein network | https://string-db.org/network/9606.ENSP00000435233 | Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...] |
| ZSCAN5C protein network | https://string-db.org/network/9606.ENSP00000435234 | Putative zinc finger and SCAN domain-containing protein 5C; May be involved in transcriptional regulation; SCAN domain containing |
| PAFAH1B2 protein network | https://string-db.org/network/9606.ENSP00000435289 | Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit |
| CRACR2B protein network | https://string-db.org/network/9606.ENSP00000435299 | EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE); EF-hand domain containing |
| PCDHA4 protein network | https://string-db.org/network/9606.ENSP00000435300 | Protocadherin alpha-4; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of spec [...] |
| NPIPA8 protein network | https://string-db.org/network/9606.ENSP00000435325 | Nuclear pore complex interacting protein family member A8 |
| RTL1 protein network | https://string-db.org/network/9606.ENSP00000435342 | Retrotransposon-like protein 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta; Retrotransposon Gag li [...] |
| GJB7 protein network | https://string-db.org/network/9606.ENSP00000435355 | Gap junction beta-7 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| TOR1AIP1 protein network | https://string-db.org/network/9606.ENSP00000435365 | Torsin-1A-interacting protein 1; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-typ [...] |
| FAU protein network | https://string-db.org/network/9606.ENSP00000435370 | Ubiquitin-like protein FUBI; FAU, ubiquitin like and ribosomal protein S30 fusion |
| CCNJ protein network | https://string-db.org/network/9606.ENSP00000435373 | Cyclin-J; Cyclin J; Cyclins |
| SLN protein network | https://string-db.org/network/9606.ENSP00000435380 | Sarcolipin; Reversibly inhibits the activity of ATP2A1 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation [...] |
| RPS6KA1 protein network | https://string-db.org/network/9606.ENSP00000435412 | Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the [...] |
| OR5M1 protein network | https://string-db.org/network/9606.ENSP00000435416 | Olfactory receptor 5M1; Odorant receptor; Olfactory receptors, family 5 |
| DDIAS protein network | https://string-db.org/network/9606.ENSP00000435421 | DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival |
| LGALS8 protein network | https://string-db.org/network/9606.ENSP00000435460 | Galectin 8; Galectins |
| KIRREL3 protein network | https://string-db.org/network/9606.ENSP00000435466 | Kin of IRRE-like protein 3; Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target- specific synapses at hippocampal mossy fiber synap [...] |
| POLN protein network | https://string-db.org/network/9606.ENSP00000435506 | DNA polymerase nu; DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurat [...] |
| ZIC4 protein network | https://string-db.org/network/9606.ENSP00000435509 | Zinc finger protein ZIC 4; Binds to DNA; Zinc fingers C2H2-type |
| ZC2HC1C protein network | https://string-db.org/network/9606.ENSP00000435550 | Zinc finger C2HC-type containing 1C; Belongs to the ZC2HC1 family |
| MROH1 protein network | https://string-db.org/network/9606.ENSP00000435565 | Maestro heat like repeat family member 1 |
| AGBL2 protein network | https://string-db.org/network/9606.ENSP00000435582 | Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational [...] |
| EPS8L2 protein network | https://string-db.org/network/9606.ENSP00000435585 | Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In [...] |
| EID3 protein network | https://string-db.org/network/9606.ENSP00000435619 | EP300-interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The com [...] |
| C1orf94 protein network | https://string-db.org/network/9606.ENSP00000435634 | Uncharacterized protein C1orf94; Chromosome 1 open reading frame 94 |
| CNTN5 protein network | https://string-db.org/network/9606.ENSP00000435637 | Contactin-5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal [...] |
| GRIK4 protein network | https://string-db.org/network/9606.ENSP00000435648 | Glutamate receptor ionotropic, kainate 4; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Gl [...] |
| ASCL3 protein network | https://string-db.org/network/9606.ENSP00000435770 | Achaete-scute homolog 3; Transcriptional repressor. Inhibits myogenesis (By similarity); Basic helix-loop-helix proteins |
| RPS13 protein network | https://string-db.org/network/9606.ENSP00000435777 | Ribosomal protein S13 |
| EHF protein network | https://string-db.org/network/9606.ENSP00000435835 | ETS homologous factor; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-res [...] |
| CELF1 protein network | https://string-db.org/network/9606.ENSP00000435926 | CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability [...] |
| KCNV1 protein network | https://string-db.org/network/9606.ENSP00000435954 | Potassium voltage-gated channel subfamily V member 1; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the thresh [...] |
| OR5M10 protein network | https://string-db.org/network/9606.ENSP00000436004 | Olfactory receptor 5M10; Odorant receptor; Olfactory receptors, family 5 |
| TRAPPC4 protein network | https://string-db.org/network/9606.ENSP00000436005 | Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Trafficking protein particle complex |
| PCDHA9 protein network | https://string-db.org/network/9606.ENSP00000436042 | Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| ST3GAL4 protein network | https://string-db.org/network/9606.ENSP00000436047 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences [...] |
| EIF3M protein network | https://string-db.org/network/9606.ENSP00000436049 | Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| SAA2 protein network | https://string-db.org/network/9606.ENSP00000436126 | Serum amyloid A-2 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family |
| TP53I11 protein network | https://string-db.org/network/9606.ENSP00000436152 | Tumor protein p53 inducible protein 11 |
| ZNF707 protein network | https://string-db.org/network/9606.ENSP00000436212 | Zinc finger protein 707; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| KBTBD3 protein network | https://string-db.org/network/9606.ENSP00000436262 | Kelch repeat and BTB domain containing 3 |
| CCS protein network | https://string-db.org/network/9606.ENSP00000436318 | Copper chaperone for superoxide dismutase; Delivers copper to copper zinc superoxide dismutase (SOD1) |
| OMP protein network | https://string-db.org/network/9606.ENSP00000436376 | Olfactory marker protein; May act as a modulator of the olfactory signal- transduction cascade; Belongs to the olfactory marker protein family |
| OR4D10 protein network | https://string-db.org/network/9606.ENSP00000436424 | Olfactory receptor 4D10; Odorant receptor; Olfactory receptors, family 4 |
| PCDHA7 protein network | https://string-db.org/network/9606.ENSP00000436426 | Protocadherin alpha-7; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of spec [...] |
| TAS2R46 protein network | https://string-db.org/network/9606.ENSP00000436450 | Taste receptor type 2 member 46; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| OR52I1 protein network | https://string-db.org/network/9606.ENSP00000436453 | Olfactory receptor 52I1; Odorant receptor; Olfactory receptors, family 52 |
| NUCB2 protein network | https://string-db.org/network/9606.ENSP00000436455 | Nucleobindin-2; Calcium-binding protein. May have a role in calcium homeostasis; EF-hand domain containing |
| IGSF9B protein network | https://string-db.org/network/9606.ENSP00000436552 | Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development. May mediate homophilic cell adhesion; Fibronec [...] |
| PCDHA5 protein network | https://string-db.org/network/9606.ENSP00000436557 | Protocadherin alpha-5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| PRR23D2 protein network | https://string-db.org/network/9606.ENSP00000436580 | Proline rich 23 domain containing 2 |
| ECHDC1 protein network | https://string-db.org/network/9606.ENSP00000436585 | Ethylmalonyl-CoA decarboxylase; Decarboxylases ethylmalonyl-CoA decarboxylase, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Als [...] |
| TMEM218 protein network | https://string-db.org/network/9606.ENSP00000436596 | Transmembrane protein 218; May be involved in ciliary biogenesis or function |
| GALNT4 protein network | https://string-db.org/network/9606.ENSP00000436604 | Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| ADM protein network | https://string-db.org/network/9606.ENSP00000436607 | ADM; AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, [...] |
| C8orf82 protein network | https://string-db.org/network/9606.ENSP00000436621 | UPF0598 protein C8orf82; Chromosome 8 open reading frame 82 |
| NXF1 protein network | https://string-db.org/network/9606.ENSP00000436679 | Nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (T [...] |
| ARMS2 protein network | https://string-db.org/network/9606.ENSP00000436682 | Age-related maculopathy susceptibility 2 |
| CARD18 protein network | https://string-db.org/network/9606.ENSP00000436691 | Caspase recruitment domain-containing protein 18; Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B; Casp [...] |
| HCAR3 protein network | https://string-db.org/network/9606.ENSP00000436714 | Hydroxycarboxylic acid receptor 3; Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiol [...] |
| ENSG00000254536 protein network | https://string-db.org/network/9606.ENSP00000436767 | Mitochondrial GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity |
| SLC52A2 protein network | https://string-db.org/network/9606.ENSP00000436768 | Solute carrier family 52, riboflavin transporter, member 2; Riboflavin transporter. Riboflavin transport is Na(+)- independent but moderately pH-sensitive. Activity is strongly inhibited by ribof [...] |
| KIAA0100 protein network | https://string-db.org/network/9606.ENSP00000436773 | Protein KIAA0100; May be involved in membrane trafficking; Belongs to the SABRE family |
| SLC35F2 protein network | https://string-db.org/network/9606.ENSP00000436785 | Solute carrier family 35 member F2; Putative solute transporter |
| KMT2A protein network | https://string-db.org/network/9606.ENSP00000436786 | Histone-lysine N-methyltransferase 2A; Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein com [...] |
| MUC5B protein network | https://string-db.org/network/9606.ENSP00000436812 | Mucin-5B; Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus; Mucins |
| CACNG5 protein network | https://string-db.org/network/9606.ENSP00000436836 | Voltage-dependent calcium channel gamma-5 subunit; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of [...] |
| C11orf48 protein network | https://string-db.org/network/9606.ENSP00000436848 | LBH domain-containing protein 1; Chromosome 11 open reading frame 48 |
| DBX1 protein network | https://string-db.org/network/9606.ENSP00000436881 | Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major cl [...] |
| PRR23D1 protein network | https://string-db.org/network/9606.ENSP00000436891 | Proline-rich protein 23D1; Proline rich 23 domain containing 1; Belongs to the PRR23 family |
| SMIM3 protein network | https://string-db.org/network/9606.ENSP00000436897 | Small integral membrane protein 3 |
| DPF2 protein network | https://string-db.org/network/9606.ENSP00000436901 | Zinc finger protein ubi-d4; May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development an [...] |
| NFRKB protein network | https://string-db.org/network/9606.ENSP00000436926 | Nuclear factor related to kappa-B-binding protein; Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'; Belongs to the NFRKB family |
| DNAAF3 protein network | https://string-db.org/network/9606.ENSP00000436975 | Dynein assembly factor 3, axonemal; Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia; Belongs [...] |
| CYB5R2 protein network | https://string-db.org/network/9606.ENSP00000437041 | NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemogl [...] |
| MYO18A protein network | https://string-db.org/network/9606.ENSP00000437073 | Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi memb [...] |
| CHI3L2 protein network | https://string-db.org/network/9606.ENSP00000437082 | Chitinase-3-like protein 2; Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity; Belongs to the glycosyl hydrolase 18 family |
| TIAM2 protein network | https://string-db.org/network/9606.ENSP00000437188 | T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimu [...] |
| DICER1 protein network | https://string-db.org/network/9606.ENSP00000437256 | Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs an [...] |
| TNKS1BP1 protein network | https://string-db.org/network/9606.ENSP00000437271 | 182 kDa tankyrase-1-binding protein; Tankyrase 1 binding protein 1 |
| ZAR1L protein network | https://string-db.org/network/9606.ENSP00000437289 | ZAR1-like protein; Zinc fingers 3CxxC-type; Belongs to the ZAR1 family |
| ENO2 protein network | https://string-db.org/network/9606.ENSP00000437402 | Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons a [...] |
| GRAPL protein network | https://string-db.org/network/9606.ENSP00000437409 | GRB2-related adapter protein-like; GRB2 related adaptor protein like; SH2 domain containing |
| FBXL17 protein network | https://string-db.org/network/9606.ENSP00000437464 | F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and leucine rich repeat proteins |
| CCDC166 protein network | https://string-db.org/network/9606.ENSP00000437468 | Coiled-coil domain containing 166 |
| FZD3 protein network | https://string-db.org/network/9606.ENSP00000437489 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of [...] |
| C16orf93 protein network | https://string-db.org/network/9606.ENSP00000437532 | Coiled-coil domain-containing protein 189; Chromosome 16 open reading frame 93 |
| LATS1 protein network | https://string-db.org/network/9606.ENSP00000437550 | Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation [...] |
| IQSEC3 protein network | https://string-db.org/network/9606.ENSP00000437554 | IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 |
| ENSG00000255641 protein network | https://string-db.org/network/9606.ENSP00000437563 | Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells |
| ZNF611 protein network | https://string-db.org/network/9606.ENSP00000437616 | Zinc finger protein 611; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HMGA2 protein network | https://string-db.org/network/9606.ENSP00000437621 | High mobility group protein HMGI-C; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiot [...] |
| OR6J1 protein network | https://string-db.org/network/9606.ENSP00000437629 | Olfactory receptor 6J1; Odorant receptor; Olfactory receptors, family 6 |
| SLFN12L protein network | https://string-db.org/network/9606.ENSP00000437635 | Schlafen family member 12 like; Belongs to the Schlafen family |
| HTR2A protein network | https://string-db.org/network/9606.ENSP00000437737 | 5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, p [...] |
| SFSWAP protein network | https://string-db.org/network/9606.ENSP00000437738 | Splicing factor, suppressor of white-apricot homolog; Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of [...] |
| BCORL1 protein network | https://string-db.org/network/9606.ENSP00000437775 | BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence- specific DNA-binding proteins such as BCL6. [...] |
| LDHC protein network | https://string-db.org/network/9606.ENSP00000437783 | L-lactate dehydrogenase C chain; Possible role in sperm motility |
| CDH22 protein network | https://string-db.org/network/9606.ENSP00000437790 | Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the [...] |
| C12orf43 protein network | https://string-db.org/network/9606.ENSP00000437803 | Uncharacterized protein C12orf43; Chromosome 12 open reading frame 43 |
| FAM106A protein network | https://string-db.org/network/9606.ENSP00000437812 | Protein FAM106A; Family with sequence similarity 106 member A; Belongs to the FAM106 family |
| ZNF641 protein network | https://string-db.org/network/9606.ENSP00000437832 | Zinc finger protein 641; Transcriptional activator. Activates transcriptional activities of SRE and AP-1; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TRPM1 protein network | https://string-db.org/network/9606.ENSP00000437849 | Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade [...] |
| GPRASP2 protein network | https://string-db.org/network/9606.ENSP00000437872 | G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors; Belongs to the GPRASP family |
| MTRNR2L5 protein network | https://string-db.org/network/9606.ENSP00000437910 | Humanin-like 5; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| CD19 protein network | https://string-db.org/network/9606.ENSP00000437940 | B-lymphocyte antigen CD19; Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation; CD molecules |
| HIF1A protein network | https://string-db.org/network/9606.ENSP00000437955 | Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, incl [...] |
| KIAA2012 protein network | https://string-db.org/network/9606.ENSP00000437957 | Uncharacterized protein KIAA2012 |
| HEATR5A protein network | https://string-db.org/network/9606.ENSP00000437968 | HEAT repeat-containing protein 5A; Armadillo-like helical domain containing |
| KLRC1 protein network | https://string-db.org/network/9606.ENSP00000438038 | NKG2-A/NKG2-B type II integral membrane protein; Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells; C-type lectin domain contain [...] |
| CCDC91 protein network | https://string-db.org/network/9606.ENSP00000438040 | Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydr [...] |
| SAMD8 protein network | https://string-db.org/network/9606.ENSP00000438042 | Sphingomyelin synthase-related protein 1; Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endopl [...] |
| GGA3 protein network | https://string-db.org/network/9606.ENSP00000438085 | ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clath [...] |
| ENSG00000276418 protein network | https://string-db.org/network/9606.ENSP00000438113 | Tumor protein D52 |
| COPS7A protein network | https://string-db.org/network/9606.ENSP00000438115 | COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator [...] |
| MDH1 protein network | https://string-db.org/network/9606.ENSP00000438144 | Malate dehydrogenase, cytoplasmic; Malate dehydrogenase 1; Belongs to the LDH/MDH superfamily. MDH type 2 family |
| TOMM5 protein network | https://string-db.org/network/9606.ENSP00000438204 | Mitochondrial import receptor subunit TOM5 homolog; Translocase of outer mitochondrial membrane complex |
| MANSC1 protein network | https://string-db.org/network/9606.ENSP00000438205 | MANSC domain containing 1 |
| SP6 protein network | https://string-db.org/network/9606.ENSP00000438209 | Transcription factor Sp6; Promotes cell proliferation; Sp transcription factors |
| KLRF2 protein network | https://string-db.org/network/9606.ENSP00000438244 | Killer cell lectin-like receptor subfamily F member 2; C-type lectin-like receptor involved in natural killer cell mediated cytotoxicity and cytokine secretion in keratinocytes via its interactio [...] |
| CALU protein network | https://string-db.org/network/9606.ENSP00000438248 | Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity [...] |
| TJP2 protein network | https://string-db.org/network/9606.ENSP00000438262 | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family |
| LRIT2 protein network | https://string-db.org/network/9606.ENSP00000438264 | Leucine rich repeat, Ig-like and transmembrane domains 2; I-set domain containing |
| BBS12 protein network | https://string-db.org/network/9606.ENSP00000438273 | Bardet-Biedl syndrome 12 protein; Probable molecular chaperone. Assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a co [...] |
| PDE10A protein network | https://string-db.org/network/9606.ENSP00000438284 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP a [...] |
| MAGEA8 protein network | https://string-db.org/network/9606.ENSP00000438293 | Melanoma-associated antigen 8; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family |
| REEP1 protein network | https://string-db.org/network/9606.ENSP00000438346 | Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surf [...] |
| TRMT112 protein network | https://string-db.org/network/9606.ENSP00000438349 | Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) po [...] |
| KIF1A protein network | https://string-db.org/network/9606.ENSP00000438388 | Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily |
| IST1 protein network | https://string-db.org/network/9606.ENSP00000438399 | IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in [...] |
| CLDN24 protein network | https://string-db.org/network/9606.ENSP00000438400 | Putative claudin-24; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| TIMM8B protein network | https://string-db.org/network/9606.ENSP00000438455 | Mitochondrial import inner membrane translocase subunit Tim8 B; Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane prote [...] |
| PGAM5 protein network | https://string-db.org/network/9606.ENSP00000438465 | Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosph [...] |
| HHAT protein network | https://string-db.org/network/9606.ENSP00000438468 | Protein-cysteine N-palmitoyltransferase HHAT; Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling. May bind GTP; Belongs to the membrane-bound acyltransferase family. [...] |
| KPNA2 protein network | https://string-db.org/network/9606.ENSP00000438483 | Importin subunit alpha-1; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or biparti [...] |
| RAB40C protein network | https://string-db.org/network/9606.ENSP00000438492 | Ras-related protein Rab-40C; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...] |
| ENSG00000272822 protein network | https://string-db.org/network/9606.ENSP00000438507 | Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family |
| KLHL35 protein network | https://string-db.org/network/9606.ENSP00000438526 | Kelch-like protein 35; Kelch like family member 35; BTB domain containing |
| ZC3H11A protein network | https://string-db.org/network/9606.ENSP00000438527 | Zinc finger CCCH domain-containing protein 11A; Involved in nuclear mRNA export; probably mediated by assoociation with the TREX complex; Zinc fingers CCCH-type |
| PLSCR3 protein network | https://string-db.org/network/9606.ENSP00000438547 | Phospholipid scramblase 3; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry [...] |
| H2AFJ protein network | https://string-db.org/network/9606.ENSP00000438553 | Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones ther [...] |
| C1R protein network | https://string-db.org/network/9606.ENSP00000438615 | Complement C1r subcomponent; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the pept [...] |
| ACADVL protein network | https://string-db.org/network/9606.ENSP00000438689 | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, mysritoyl-CoA and stearoyl-CoA. Can accom [...] |
| SMG8 protein network | https://string-db.org/network/9606.ENSP00000438748 | Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SM [...] |
| PRR20C protein network | https://string-db.org/network/9606.ENSP00000438757 | Proline-rich protein 20A; Proline rich 20C |
| CUL7 protein network | https://string-db.org/network/9606.ENSP00000438788 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubu [...] |
| OR13C2 protein network | https://string-db.org/network/9606.ENSP00000438815 | Olfactory receptor 13C2; Odorant receptor; Olfactory receptors, family 13 |
| TMEM206 protein network | https://string-db.org/network/9606.ENSP00000438863 | Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediat [...] |
| NOVA1 protein network | https://string-db.org/network/9606.ENSP00000438875 | RNA-binding protein Nova-1; May regulate RNA splicing or metabolism in a specific subset of developing neurons |
| CDK5RAP3 protein network | https://string-db.org/network/9606.ENSP00000438886 | CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF-kappa-B-mediated gene t [...] |
| CACNB4 protein network | https://string-db.org/network/9606.ENSP00000438949 | Voltage-dependent L-type calcium channel subunit beta-4; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium curre [...] |
| ZCCHC8 protein network | https://string-db.org/network/9606.ENSP00000438993 | Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non- coding short-lived RNAs for exo [...] |
| DBI protein network | https://string-db.org/network/9606.ENSP00000439012 | Acyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepa [...] |
| ZNF426 protein network | https://string-db.org/network/9606.ENSP00000439017 | Zinc finger protein 426; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HAUS5 protein network | https://string-db.org/network/9606.ENSP00000439056 | HAUS augmin-like complex subunit 5; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex |
| COA8 protein network | https://string-db.org/network/9606.ENSP00000439065 | Uncharacterized protein; Kinesin light chain 1 |
| CRADD protein network | https://string-db.org/network/9606.ENSP00000439068 | Death domain-containing protein CRADD; Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. In the presence of RIP and TRADD, CRADD recruits caspase-2 [...] |
| NFE2 protein network | https://string-db.org/network/9606.ENSP00000439120 | Transcription factor NF-E2 45 kDa subunit; Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 [...] |
| BANF2 protein network | https://string-db.org/network/9606.ENSP00000439128 | Barrier-to-autointegration factor-like protein; May play a role in BANF1 regulation and influence tissue-specific roles of BANF1; Belongs to the BAF family |
| TBCE protein network | https://string-db.org/network/9606.ENSP00000439170 | Tubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct o [...] |
| MYO1H protein network | https://string-db.org/network/9606.ENSP00000439182 | Unconventional myosin-Ih; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind [...] |
| POTEE protein network | https://string-db.org/network/9606.ENSP00000439189 | POTE ankyrin domain family member E; In the C-terminal section; belongs to the actin family |
| MTRNR2L1 protein network | https://string-db.org/network/9606.ENSP00000439228 | Humanin-like 1; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| CIZ1 protein network | https://string-db.org/network/9606.ENSP00000439244 | Cip1-interacting zinc finger protein; May regulate the subcellular localization of CIP/WAF1 |
| FKBP9 protein network | https://string-db.org/network/9606.ENSP00000439250 | Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis; EF-hand domain containing |
| TRDN protein network | https://string-db.org/network/9606.ENSP00000439281 | Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contractio [...] |
| RIMS4 protein network | https://string-db.org/network/9606.ENSP00000439287 | Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis |
| SSUH2 protein network | https://string-db.org/network/9606.ENSP00000439378 | Protein SSUH2 homolog; Plays a role in odontogenesis |
| ZNF667 protein network | https://string-db.org/network/9606.ENSP00000439402 | Zinc finger protein 667; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ANAPC15 protein network | https://string-db.org/network/9606.ENSP00000439403 | Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| ZNF133 protein network | https://string-db.org/network/9606.ENSP00000439427 | Zinc finger protein 133; May be involved in transcriptional regulation as a repressor; Zinc fingers C2H2-type |
| ZNF415 protein network | https://string-db.org/network/9606.ENSP00000439435 | Zinc finger protein 415; Involved in transcriptional regulation. Transcriptional activity differed among the various isoforms. All isoforms except isoform 3 seem to suppresses the transcriptional [...] |
| PPIAL4D protein network | https://string-db.org/network/9606.ENSP00000439444 | Peptidyl-prolyl cis-trans isomerase A-like 4D; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...] |
| TARM1 protein network | https://string-db.org/network/9606.ENSP00000439454 | T-cell-interacting, activating receptor on myeloid cells protein 1; May act as receptor (By similarity). Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by [...] |
| PDCD2 protein network | https://string-db.org/network/9606.ENSP00000439467 | Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation; Zinc fingers MYND-ty [...] |
| DMXL1 protein network | https://string-db.org/network/9606.ENSP00000439479 | DmX-like protein 1; WD repeat domain containing |
| ANHX protein network | https://string-db.org/network/9606.ENSP00000439513 | Anomalous homeobox |
| ENSG00000277737 protein network | https://string-db.org/network/9606.ENSP00000439534 | annotation not available |
| ATXN7 protein network | https://string-db.org/network/9606.ENSP00000439585 | Ataxin-7; Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary [...] |
| HMHA1 protein network | https://string-db.org/network/9606.ENSP00000439601 | Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. [...] |
| PLEKHG5 protein network | https://string-db.org/network/9606.ENSP00000439625 | Pleckstrin homology domain-containing family G member 5; Guanine nucleotide exchange factor that activates RHOA and maybe the NF-kappa-B signaling pathway. Involved in the control of neuronal cel [...] |
| MTRNR2L8 protein network | https://string-db.org/network/9606.ENSP00000439666 | MT-RNR2 like 8; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| TRERF1 protein network | https://string-db.org/network/9606.ENSP00000439689 | Transcriptional-regulating factor 1; Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1; Myb/SANT d [...] |
| TMEM50B protein network | https://string-db.org/network/9606.ENSP00000439768 | Belongs to the UPF0220 family |
| ENSG00000269905 protein network | https://string-db.org/network/9606.ENSP00000439782 | Transcription factor Dp-2; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter reg [...] |
| MPDZ protein network | https://string-db.org/network/9606.ENSP00000439807 | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface (By similarity). Member of the NMDAR signaling complex that may play a role in control of AMPAR p [...] |
| CHERP protein network | https://string-db.org/network/9606.ENSP00000439856 | Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation; G-patch domain containing |
| LOC110117498-PIK3R3 protein network | https://string-db.org/network/9606.ENSP00000439913 | Uncharacterized protein; Phosphatidylinositol 3-kinase regulatory subunit gamma |
| HOMER3 protein network | https://string-db.org/network/9606.ENSP00000439937 | Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 [...] |
| MTRNR2L7 protein network | https://string-db.org/network/9606.ENSP00000439985 | Humanin-like 7; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| ARF1 protein network | https://string-db.org/network/9606.ENSP00000440005 | ADP-ribosylation factor 1; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking among [...] |
| TCEANC protein network | https://string-db.org/network/9606.ENSP00000440038 | Transcription elongation factor A N-terminal and central domain containing |
| ATP2A2 protein network | https://string-db.org/network/9606.ENSP00000440045 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic [...] |
| CPNE6 protein network | https://string-db.org/network/9606.ENSP00000440077 | Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). [...] |
| FAM120B protein network | https://string-db.org/network/9606.ENSP00000440125 | Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation (By similarity); [...] |
| FAM9A protein network | https://string-db.org/network/9606.ENSP00000440163 | Protein FAM9A; Family with sequence similarity 9 member A |
| RAB19 protein network | https://string-db.org/network/9606.ENSP00000440167 | Ras-related protein Rab-19; RAB19, member RAS oncogene family; Belongs to the small GTPase superfamily. Rab family |
| PDYN protein network | https://string-db.org/network/9606.ENSP00000440185 | Proenkephalin-B; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By s [...] |
| TDRD3 protein network | https://string-db.org/network/9606.ENSP00000440190 | Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmet [...] |
| TBC1D30 protein network | https://string-db.org/network/9606.ENSP00000440207 | TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro |
| LUC7L2 protein network | https://string-db.org/network/9606.ENSP00000440222 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain |
| ME3 protein network | https://string-db.org/network/9606.ENSP00000440246 | NADP-dependent malic enzyme, mitochondrial; Malic enzyme 3; Belongs to the malic enzymes family |
| ENSG00000255767 protein network | https://string-db.org/network/9606.ENSP00000440272 | Uncharacterized protein |
| SH2B2 protein network | https://string-db.org/network/9606.ENSP00000440273 | SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras [...] |
| ABCB9 protein network | https://string-db.org/network/9606.ENSP00000440288 | ATP-binding cassette sub-family B member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broa [...] |
| ADIG protein network | https://string-db.org/network/9606.ENSP00000440331 | Adipogenin; Plays a role in stimulating adipocyte differentiation and development |
| ZNF124 protein network | https://string-db.org/network/9606.ENSP00000440365 | Zinc finger protein 124; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| MCF2L protein network | https://string-db.org/network/9606.ENSP00000440374 | Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC4 [...] |
| ANKRD49 protein network | https://string-db.org/network/9606.ENSP00000440396 | Ankyrin repeat domain-containing protein 49; Induces HBG1 expression. May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF- kappaB pathway (B [...] |
| DDX11 protein network | https://string-db.org/network/9606.ENSP00000440402 | ATP-dependent DNA helicase DDX11; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and hetero [...] |
| CLEC4C protein network | https://string-db.org/network/9606.ENSP00000440428 | C-type lectin domain family 4 member C; Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non- sialylated galactose-terminat [...] |
| ATF7IP protein network | https://string-db.org/network/9606.ENSP00000440440 | Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chrom [...] |
| ZNF573 protein network | https://string-db.org/network/9606.ENSP00000440464 | Zinc finger protein 573; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PSMD9 protein network | https://string-db.org/network/9606.ENSP00000440485 | 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During [...] |
| GDAP1L1 protein network | https://string-db.org/network/9606.ENSP00000440498 | Ganglioside-induced differentiation-associated protein 1-like 1; Ganglioside induced differentiation associated protein 1 like 1 |
| KIAA1958 protein network | https://string-db.org/network/9606.ENSP00000440504 | Uncharacterized protein KIAA1958; KIAA1958 |
| TIFAB protein network | https://string-db.org/network/9606.ENSP00000440509 | TRAF-interacting protein with FHA domain-containing protein B; Inhibits TIFA-mediated TRAF6 activation possibly by inducing a conformational change in TIFA |
| GRM4 protein network | https://string-db.org/network/9606.ENSP00000440556 | Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G protein [...] |
| VNN3 protein network | https://string-db.org/network/9606.ENSP00000440594 | Vascular non-inflammatory molecule 3; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cystea [...] |
| MYRFL protein network | https://string-db.org/network/9606.ENSP00000440626 | Myelin regulatory factor like |
| TMEM216 protein network | https://string-db.org/network/9606.ENSP00000440638 | Transmembrane protein 216; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition |
| TLR5 protein network | https://string-db.org/network/9606.ENSP00000440643 | Toll-like receptor 5; Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytok [...] |
| PHC1 protein network | https://string-db.org/network/9606.ENSP00000440674 | Polyhomeotic-like protein 1; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] |
| CYP2E1 protein network | https://string-db.org/network/9606.ENSP00000440689 | Cytochrome P450 2E1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrate [...] |
| NPIPB5 protein network | https://string-db.org/network/9606.ENSP00000440703 | Nuclear pore complex interacting protein family member B5 |
| SYTL1 protein network | https://string-db.org/network/9606.ENSP00000440704 | Synaptotagmin-like protein 1; May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cyto [...] |
| C16orf13 protein network | https://string-db.org/network/9606.ENSP00000440765 | Methyltransferase-like 26; Chromosome 16 open reading frame 13 |
| CACFD1 protein network | https://string-db.org/network/9606.ENSP00000440832 | Calcium channel flower domain containing 1 |
| ZNF185 protein network | https://string-db.org/network/9606.ENSP00000440847 | Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation; LIM domain containing |
| NR4A1 protein network | https://string-db.org/network/9606.ENSP00000440864 | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the N [...] |
| PLD5 protein network | https://string-db.org/network/9606.ENSP00000440896 | Inactive phospholipase D5; Phospholipase D family member 5; Belongs to the phospholipase D family |
| KIAA0391 protein network | https://string-db.org/network/9606.ENSP00000440915 | Mitochondrial ribonuclease P catalytic subunit; Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA [...] |
| PACSIN3 protein network | https://string-db.org/network/9606.ENSP00000440945 | Protein kinase C and casein kinase substrate in neurons protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of [...] |
| RASA4B protein network | https://string-db.org/network/9606.ENSP00000440982 | Ras GTPase-activating protein 4B; Pleckstrin homology domain containing; C2 and RasGAP domain containing |
| AP3B2 protein network | https://string-db.org/network/9606.ENSP00000440984 | AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and [...] |
| VARS2 protein network | https://string-db.org/network/9606.ENSP00000441000 | Valine--tRNA ligase, mitochondrial; valyl-tRNA synthetase 2, mitochondrial; Aminoacyl tRNA synthetases, Class I |
| OBP2A protein network | https://string-db.org/network/9606.ENSP00000441028 | Odorant-binding protein 2a; Probably binds and transports small hydrophobic volatile molecules with a higher affinity for aldehydes and large fatty acids; Lipocalins |
| GRAMD1A protein network | https://string-db.org/network/9606.ENSP00000441032 | GRAM domain-containing protein 1A; May play a role in tumor progression; GRAM domain containing |
| GPR161 protein network | https://string-db.org/network/9606.ENSP00000441039 | G-protein coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex [...] |
| SLC16A1 protein network | https://string-db.org/network/9606.ENSP00000441065 | Monocarboxylate transporter 1; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-ch [...] |
| NDUFC1 protein network | https://string-db.org/network/9606.ENSP00000441126 | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved [...] |
| NOL8 protein network | https://string-db.org/network/9606.ENSP00000441140 | Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expressio [...] |
| CLTCL1 protein network | https://string-db.org/network/9606.ENSP00000441158 | Clathrin heavy chain 2; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma me [...] |
| RHBG protein network | https://string-db.org/network/9606.ENSP00000441197 | Ammonium transporter Rh type B; Functions as a specific ammonium transporter; Solute carriers |
| USP36 protein network | https://string-db.org/network/9606.ENSP00000441214 | Ubiquitin carboxyl-terminal hydrolase 36; May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B a [...] |
| TSHR protein network | https://string-db.org/network/9606.ENSP00000441235 | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The act [...] |
| SLCO1B3-SLCO1B7 protein network | https://string-db.org/network/9606.ENSP00000441269 | Solute carrier organic anion transporter family member; Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukot [...] |
| CLDN2 protein network | https://string-db.org/network/9606.ENSP00000441283 | Claudin-2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity; Claudins |
| OR4D2 protein network | https://string-db.org/network/9606.ENSP00000441354 | Olfactory receptor 4D2; Odorant receptor; Olfactory receptors, family 4 |
| MARVELD1 protein network | https://string-db.org/network/9606.ENSP00000441365 | MARVEL domain-containing protein 1; Microtubule-associated protein that exhibits cell cycle- dependent localization and can inhibit cell proliferation and migration |
| MSLNL protein network | https://string-db.org/network/9606.ENSP00000441381 | Mesothelin-like protein; May play a role in cellular adhesion |
| ZNF664 protein network | https://string-db.org/network/9606.ENSP00000441405 | Zinc finger protein 664; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF135 protein network | https://string-db.org/network/9606.ENSP00000441410 | Zinc finger protein 135; Plays a role in the regulation of cell morphology and cytoskeletal organization. May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ARSE protein network | https://string-db.org/network/9606.ENSP00000441417 | Arylsulfatase E; May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates; Sulfatases |
| NNMT protein network | https://string-db.org/network/9606.ENSP00000441434 | Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenob [...] |
| SERPINB11 protein network | https://string-db.org/network/9606.ENSP00000441497 | Serpin B11; Has no serine protease inhibitory activity, probably due to mutations in the scaffold impairing conformational change; Serpin peptidase inhibitors |
| UBC protein network | https://string-db.org/network/9606.ENSP00000441543 | Polyubiquitin-C; Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as [...] |
| CCR3 protein network | https://string-db.org/network/9606.ENSP00000441600 | C-C chemokine receptor type 3; Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellul [...] |
| TAS2R20 protein network | https://string-db.org/network/9606.ENSP00000441624 | Taste receptor type 2 member 20; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| PRR14 protein network | https://string-db.org/network/9606.ENSP00000441641 | Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha. M [...] |
| PDZD9 protein network | https://string-db.org/network/9606.ENSP00000441685 | PDZ domain containing 9 |
| ITGAM protein network | https://string-db.org/network/9606.ENSP00000441691 | Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. [...] |
| CLUL1 protein network | https://string-db.org/network/9606.ENSP00000441726 | Clusterin-like protein 1; Clusterin like 1 |
| DYRK4 protein network | https://string-db.org/network/9606.ENSP00000441755 | Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYR [...] |
| PTHLH protein network | https://string-db.org/network/9606.ENSP00000441765 | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calc [...] |
| CXorf56 protein network | https://string-db.org/network/9606.ENSP00000441786 | UPF0428 protein CXorf56; Chromosome X open reading frame 56; Spliceosomal C complex |
| PCDH7 protein network | https://string-db.org/network/9606.ENSP00000441802 | Protocadherin-7; Protein phosphatase 1 regulatory subunits; Non-clustered protocadherins |
| SALL3 protein network | https://string-db.org/network/9606.ENSP00000441823 | Sal-like protein 3; Probable transcription factor; Zinc fingers C2H2-type |
| HPR protein network | https://string-db.org/network/9606.ENSP00000441828 | Haptoglobin-related protein; Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic fac [...] |
| FNDC3A protein network | https://string-db.org/network/9606.ENSP00000441831 | Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis; Belongs to the FNDC3 family |
| GPR19 protein network | https://string-db.org/network/9606.ENSP00000441832 | Probable G-protein coupled receptor 19; Orphan receptor; G protein-coupled receptors, Class A orphans |
| ZNF567 protein network | https://string-db.org/network/9606.ENSP00000441838 | Zinc finger protein 567; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| DMXL2 protein network | https://string-db.org/network/9606.ENSP00000441858 | DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles. Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By sim [...] |
| PHB2 protein network | https://string-db.org/network/9606.ENSP00000441875 | Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selecti [...] |
| ARHGEF28 protein network | https://string-db.org/network/9606.ENSP00000441913 | Rho guanine nucleotide exchange factor 28; Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Funct [...] |
| SESN3 protein network | https://string-db.org/network/9606.ENSP00000441927 | Sestrin-3; May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TO [...] |
| MUC12 protein network | https://string-db.org/network/9606.ENSP00000441929 | Mucin-12; Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF-alpha and TGF- beta in [...] |
| PIH1D3 protein network | https://string-db.org/network/9606.ENSP00000441930 | Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein; Belongs to the PIH1 family |
| TAS2R14 protein network | https://string-db.org/network/9606.ENSP00000441949 | Taste receptor type 2 member 14; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| ORC4 protein network | https://string-db.org/network/9606.ENSP00000441953 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define ori [...] |
| SMAD5 protein network | https://string-db.org/network/9606.ENSP00000441954 | Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) |
| CEPT1 protein network | https://string-db.org/network/9606.ENSP00000441980 | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-de [...] |
| TMTC1 protein network | https://string-db.org/network/9606.ENSP00000442046 | Transmembrane and tetratricopeptide repeat containing 1 |
| PCYT2 protein network | https://string-db.org/network/9606.ENSP00000442050 | Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine |
| RBM19 protein network | https://string-db.org/network/9606.ENSP00000442053 | Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development; RNA binding motif containing |
| CDCA3 protein network | https://string-db.org/network/9606.ENSP00000442068 | Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation [...] |
| HDGFL1 protein network | https://string-db.org/network/9606.ENSP00000442129 | Hepatoma-derived growth factor-like protein 1; Heparin binding growth factor family; Belongs to the HDGF family |
| PIANP protein network | https://string-db.org/network/9606.ENSP00000442157 | PILR alpha-associated neural protein; Acts as a ligand for PILRA in neural tissues, where it may be involved in immune regulation |
| MTRNR2L10 protein network | https://string-db.org/network/9606.ENSP00000442159 | Humanin-like 10; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| IQCC protein network | https://string-db.org/network/9606.ENSP00000442291 | IQ motif containing C |
| FAM132B protein network | https://string-db.org/network/9606.ENSP00000442304 | Erythroferrone; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression [...] |
| ECT2L protein network | https://string-db.org/network/9606.ENSP00000442307 | Epithelial cell-transforming sequence 2 oncogene-like; May act as a guanine nucleotide exchange factor (GEF); F-boxes other |
| NKRF protein network | https://string-db.org/network/9606.ENSP00000442308 | NF-kappa-B-repressing factor; Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved [...] |
| CAND1 protein network | https://string-db.org/network/9606.ENSP00000442318 | Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box sub [...] |
| TOP3A protein network | https://string-db.org/network/9606.ENSP00000442336 | DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the D [...] |
| ZDHHC11B protein network | https://string-db.org/network/9606.ENSP00000442373 | Probable palmitoyltransferase ZDHHC11B; Zinc finger DHHC-type containing 11B |
| JHDM3C protein network | https://string-db.org/network/9606.ENSP00000442382 | Lysine-specific demethylase 4C; Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethyla [...] |
| SLC34A3 protein network | https://string-db.org/network/9606.ENSP00000442397 | Sodium-dependent phosphate transport protein 2C; May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% o [...] |
| KRTCAP3 protein network | https://string-db.org/network/9606.ENSP00000442400 | Keratinocyte associated protein 3 |
| IL22 protein network | https://string-db.org/network/9606.ENSP00000442424 | Interleukin-22; Cytokine that contributes to the inflammatory response in vivo; Interleukins |
| MIXL1 protein network | https://string-db.org/network/9606.ENSP00000442439 | Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the pr [...] |
| ENSG00000259040 protein network | https://string-db.org/network/9606.ENSP00000442453 | BLOC1S5-TXNDC5 readthrough |
| PTK6 protein network | https://string-db.org/network/9606.ENSP00000442460 | Protein-tyrosine kinase 6; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epitheli [...] |
| NCEH1 protein network | https://string-db.org/network/9606.ENSP00000442464 | Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsibl [...] |
| ASIC5 protein network | https://string-db.org/network/9606.ENSP00000442477 | Acid-sensing ion channel 5; Cation channel that gives rise to very low constitutive currents in the absence of activation. The activated channel exhibits selectivity for sodium, and is inhibited [...] |
| STOML1 protein network | https://string-db.org/network/9606.ENSP00000442478 | Stomatin-like protein 1; May play a role in cholesterol transfer to late endosomes. May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current [...] |
| TTLL9 protein network | https://string-db.org/network/9606.ENSP00000442515 | Probable tubulin polyglutamylase TTLL9; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins (By similarity); Tubulin [...] |
| BEX2 protein network | https://string-db.org/network/9606.ENSP00000442521 | Protein BEX2; Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the mod [...] |
| POLG2 protein network | https://string-db.org/network/9606.ENSP00000442563 | DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. B [...] |
| ZNF668 protein network | https://string-db.org/network/9606.ENSP00000442573 | Zinc finger protein 668; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| DAG1 protein network | https://string-db.org/network/9606.ENSP00000442600 | Dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, n [...] |
| PRB3 protein network | https://string-db.org/network/9606.ENSP00000442626 | Basic salivary proline-rich protein 3; Acts as a receptor for the Gram-negative bacterium F.nucleatum; Proline rich proteins |
| ACVR1B protein network | https://string-db.org/network/9606.ENSP00000442656 | Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin [...] |
| ADAP1 protein network | https://string-db.org/network/9606.ENSP00000442682 | Arf-GAP with dual PH domain-containing protein 1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5- trisphosphate (PtdInsP3) and inosi [...] |
| MFSD5 protein network | https://string-db.org/network/9606.ENSP00000442688 | Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily |
| HTATSF1 protein network | https://string-db.org/network/9606.ENSP00000442699 | HIV Tat-specific factor 1; Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on tr [...] |
| PLXNB3 protein network | https://string-db.org/network/9606.ENSP00000442736 | Plexin-B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In gliom [...] |
| GPN3 protein network | https://string-db.org/network/9606.ENSP00000442770 | GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family |
| LMO3 protein network | https://string-db.org/network/9606.ENSP00000442786 | LIM domain only protein 3; LIM domain containing |
| TET2 protein network | https://string-db.org/network/9606.ENSP00000442788 | Methylcytosine dioxygenase TET2; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in active [...] |
| BEAN1 protein network | https://string-db.org/network/9606.ENSP00000442793 | Protein BEAN1; Brain expressed associated with NEDD4 1 |
| MYBPC3 protein network | https://string-db.org/network/9606.ENSP00000442795 | Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin f [...] |
| RGS13 protein network | https://string-db.org/network/9606.ENSP00000442837 | Regulator of G-protein signaling 13; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to b [...] |
| SETD1B protein network | https://string-db.org/network/9606.ENSP00000442924 | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if [...] |
| APC2 protein network | https://string-db.org/network/9606.ENSP00000442954 | Adenomatous polyposis coli protein 2; Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting t [...] |
| DAPK3 protein network | https://string-db.org/network/9606.ENSP00000442973 | Death-associated protein kinase 3; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved [...] |
| GPR17 protein network | https://string-db.org/network/9606.ENSP00000442982 | Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. Ma [...] |
| HIST4H4 protein network | https://string-db.org/network/9606.ENSP00000443017 | Histone cluster 4, H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histo [...] |
| RASSF3 protein network | https://string-db.org/network/9606.ENSP00000443021 | Ras association domain family member 3 |
| ZCCHC7 protein network | https://string-db.org/network/9606.ENSP00000443113 | Zinc finger CCHC-type containing 7 |
| ENSG00000256591 protein network | https://string-db.org/network/9606.ENSP00000443130 | Uncharacterized protein; Succinate dehydrogenase assembly factor 2, mitochondrial |
| FAM180B protein network | https://string-db.org/network/9606.ENSP00000443133 | Protein FAM180B; Family with sequence similarity 180 member B |
| STH protein network | https://string-db.org/network/9606.ENSP00000443168 | Saitohin |
| RSPRY1 protein network | https://string-db.org/network/9606.ENSP00000443176 | Ring finger and SPRY domain containing 1 |
| ENSG00000255863 protein network | https://string-db.org/network/9606.ENSP00000443189 | Uncharacterized protein |
| KLHL13 protein network | https://string-db.org/network/9606.ENSP00000443191 | Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin [...] |
| NAT1 protein network | https://string-db.org/network/9606.ENSP00000443194 | Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine s [...] |
| C2CD5 protein network | https://string-db.org/network/9606.ENSP00000443204 | C2 domain-containing protein 5; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma [...] |
| TMEM258 protein network | https://string-db.org/network/9606.ENSP00000443216 | Transmembrane protein 258; Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide d [...] |
| ENSG00000255730 protein network | https://string-db.org/network/9606.ENSP00000443246 | Uncharacterized protein; 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; Uncharacterized protein |
| LPAR2 protein network | https://string-db.org/network/9606.ENSP00000443256 | Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of hete [...] |
| FAR2 protein network | https://string-db.org/network/9606.ENSP00000443291 | Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA subs [...] |
| FAM222A protein network | https://string-db.org/network/9606.ENSP00000443292 | Protein FAM222A; Family with sequence similarity 222 member A; Belongs to the FAM222 family |
| PFKFB3 protein network | https://string-db.org/network/9606.ENSP00000443319 | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family |
| MTRNR2L3 protein network | https://string-db.org/network/9606.ENSP00000443339 | Humanin-like 3; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| FAM46D protein network | https://string-db.org/network/9606.ENSP00000443410 | Putative nucleotidyltransferase FAM46D; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase |
| FAM92B protein network | https://string-db.org/network/9606.ENSP00000443411 | Protein FAM92B; May play a role in ciliogenesis (By similarity). In cooperation with CBY1 may facilitate ciliogenesis likely by the recruitment and fusion of endosomal vesicles at distal appendag [...] |
| IDO2 protein network | https://string-db.org/network/9606.ENSP00000443432 | Indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in immune regulation. May [...] |
| BCAT1 protein network | https://string-db.org/network/9606.ENSP00000443459 | Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine |
| ACTN2 protein network | https://string-db.org/network/9606.ENSP00000443495 | Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein; Actinins |
| MVK protein network | https://string-db.org/network/9606.ENSP00000443551 | Mevalonate kinase; May be a regulatory site in cholesterol biosynthetic pathway; Belongs to the GHMP kinase family. Mevalonate kinase subfamily |
| FAM214A protein network | https://string-db.org/network/9606.ENSP00000443598 | Protein FAM214A; Family with sequence similarity 214 member A; Belongs to the FAM214 family |
| PLCB3 protein network | https://string-db.org/network/9606.ENSP00000443631 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activ [...] |
| AUNIP protein network | https://string-db.org/network/9606.ENSP00000443647 | Aurora kinase A and ninein-interacting protein; DNA-binding protein that accumulates at DNA double- strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombinati [...] |
| TBC1D10C protein network | https://string-db.org/network/9606.ENSP00000443654 | Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that als [...] |
| ZNRF3 protein network | https://string-db.org/network/9606.ENSP00000443824 | E3 ubiquitin-protein ligase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt rec [...] |
| SP7 protein network | https://string-db.org/network/9606.ENSP00000443827 | Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity) |
| TEX40 protein network | https://string-db.org/network/9606.ENSP00000443917 | Cation channel sperm-associated protein subunit zeta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm [...] |
| CELF2 protein network | https://string-db.org/network/9606.ENSP00000443926 | CUGBP Elav-like family member 2; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability [...] |
| ZNF580 protein network | https://string-db.org/network/9606.ENSP00000443957 | Zinc finger protein 580; Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may p [...] |
| CPEB2 protein network | https://string-db.org/network/9606.ENSP00000443985 | Cytoplasmic polyadenylation element-binding protein 2; May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers [...] |
| SUDS3 protein network | https://string-db.org/network/9606.ENSP00000443988 | Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumo [...] |
| NUP153 protein network | https://string-db.org/network/9606.ENSP00000444029 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuc [...] |
| CES4A protein network | https://string-db.org/network/9606.ENSP00000444052 | Carboxylesterase 4A; Probable carboxylesterase; Carboxylesterases |
| OR52E8 protein network | https://string-db.org/network/9606.ENSP00000444054 | Olfactory receptor 52E8; Odorant receptor; Olfactory receptors, family 52 |
| NPIPB3 protein network | https://string-db.org/network/9606.ENSP00000444096 | Nuclear pore complex interacting protein family member B3 |
| OR7G1 protein network | https://string-db.org/network/9606.ENSP00000444134 | Olfactory receptor 7G1; Odorant receptor; Olfactory receptors, family 7 |
| POLR1B protein network | https://string-db.org/network/9606.ENSP00000444136 | DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core [...] |
| SLCO1C1 protein network | https://string-db.org/network/9606.ENSP00000444149 | Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other pot [...] |
| ARMC6 protein network | https://string-db.org/network/9606.ENSP00000444156 | Armadillo repeat containing 6 |
| GALNT6 protein network | https://string-db.org/network/9606.ENSP00000444171 | Polypeptide N-acetylgalactosaminyltransferase 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threo [...] |
| CITED2 protein network | https://string-db.org/network/9606.ENSP00000444198 | Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcrip [...] |
| SYT7 protein network | https://string-db.org/network/9606.ENSP00000444201 | Synaptotagmin-7; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces [...] |
| RAI2 protein network | https://string-db.org/network/9606.ENSP00000444210 | Retinoic acid induced 2 |
| PDGFRL protein network | https://string-db.org/network/9606.ENSP00000444211 | Platelet-derived growth factor receptor-like protein; Platelet derived growth factor receptor like; I-set domain containing |
| TNFAIP8L1 protein network | https://string-db.org/network/9606.ENSP00000444215 | Tumor necrosis factor alpha-induced protein 8-like protein 1; Acts as a negative regulator of mTOR activity; Belongs to the TNFAIP8 family |
| PRRG1 protein network | https://string-db.org/network/9606.ENSP00000444278 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain containing |
| ZNF701 protein network | https://string-db.org/network/9606.ENSP00000444339 | Zinc finger protein 701; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| OTUB1 protein network | https://string-db.org/network/9606.ENSP00000444357 | Ubiquitin thioesterase OTUB1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by [...] |
| SLC1A5 protein network | https://string-db.org/network/9606.ENSP00000444408 | Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all [...] |
| FRMPD1 protein network | https://string-db.org/network/9606.ENSP00000444411 | FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1; FERM domain containing |
| ZNF268 protein network | https://string-db.org/network/9606.ENSP00000444412 | Zinc finger protein 268; Isoform 1: Acts as a transcriptional repressor. Inhibits erythroid differentiation and tumor cell proliferation. Plays a role during ovarian cancer development and progre [...] |
| SCO2 protein network | https://string-db.org/network/9606.ENSP00000444433 | Protein SCO2 homolog, mitochondrial; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2); Mitochondrial respiratory chain complex assem [...] |
| SEBOX protein network | https://string-db.org/network/9606.ENSP00000444503 | Homeobox protein SEBOX; Probable transcription factor involved in the control of specification of mesoderm and endoderm; PRD class homeoboxes and pseudogenes |
| KRT86 protein network | https://string-db.org/network/9606.ENSP00000444533 | Keratin, type II cuticular Hb6; Keratins, type II |
| ARMCX6 protein network | https://string-db.org/network/9606.ENSP00000444537 | Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells; Armadillo repeat containing |
| TMEM14C protein network | https://string-db.org/network/9606.ENSP00000444561 | Transmembrane protein 14C; Required for normal heme biosynthesis |
| MYCBP2 protein network | https://string-db.org/network/9606.ENSP00000444596 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 [...] |
| GLB1L2 protein network | https://string-db.org/network/9606.ENSP00000444628 | Beta-galactosidase-1-like protein 2; Galactosidase beta 1 like 2 |
| CYFIP2 protein network | https://string-db.org/network/9606.ENSP00000444645 | Cytoplasmic FMR1-interacting protein 2; Involved in T-cell adhesion and p53/TP53-dependent induction of apoptosis. Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 en [...] |
| ATP1A3 protein network | https://string-db.org/network/9606.ENSP00000444688 | Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...] |
| TAS2R30 protein network | https://string-db.org/network/9606.ENSP00000444736 | Taste receptor type 2 member 30; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| SSH2 protein network | https://string-db.org/network/9606.ENSP00000444743 | Protein phosphatase Slingshot homolog 2; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequ [...] |
| ZNF835 protein network | https://string-db.org/network/9606.ENSP00000444747 | Zinc finger protein 835; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TDO2 protein network | https://string-db.org/network/9606.ENSP00000444788 | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyze [...] |
| FKBP5 protein network | https://string-db.org/network/9606.ENSP00000444810 | Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-sho [...] |
| ZNF324 protein network | https://string-db.org/network/9606.ENSP00000444812 | Zinc finger protein 324A; May be involved in transcriptional regulation. May be involved in regulation of cell proliferation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| USO1 protein network | https://string-db.org/network/9606.ENSP00000444850 | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent bind [...] |
| CUL2 protein network | https://string-db.org/network/9606.ENSP00000444856 | Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS com [...] |
| NUTM1 protein network | https://string-db.org/network/9606.ENSP00000444896 | NUT midline carcinoma family member 1 |
| PAFAH1B3 protein network | https://string-db.org/network/9606.ENSP00000444935 | Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the dev [...] |
| KCNK4 protein network | https://string-db.org/network/9606.ENSP00000444948 | Potassium channel subfamily K member 4; Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising [...] |
| C21orf62 protein network | https://string-db.org/network/9606.ENSP00000444950 | Uncharacterized protein C21orf62; Chromosome 21 open reading frame 62 |
| AP1S2 protein network | https://string-db.org/network/9606.ENSP00000444957 | AP-1 complex subunit sigma-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP co [...] |
| HCK protein network | https://string-db.org/network/9606.ENSP00000444986 | Tyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of [...] |
| CPSF3L protein network | https://string-db.org/network/9606.ENSP00000445001 | Integrator complex subunit 11; Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent proc [...] |
| APOA5 protein network | https://string-db.org/network/9606.ENSP00000445002 | Apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) l [...] |
| FRY protein network | https://string-db.org/network/9606.ENSP00000445043 | Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in earl [...] |
| CTSV protein network | https://string-db.org/network/9606.ENSP00000445052 | Cathepsin L2; Cysteine protease. May have an important role in corneal physiology; Belongs to the peptidase C1 family |
| EIF2S3L protein network | https://string-db.org/network/9606.ENSP00000445077 | Putative eukaryotic translation initiation factor 2 subunit 3-like protein; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presenc [...] |
| HSD3B2 protein network | https://string-db.org/network/9606.ENSP00000445122 | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxid [...] |
| NLRP2 protein network | https://string-db.org/network/9606.ENSP00000445135 | NACHT, LRR and PYD domains-containing protein 2; Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated [...] |
| GTF2H3 protein network | https://string-db.org/network/9606.ENSP00000445162 | General transcription factor IIH subunit 3; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcrip [...] |
| LDHA protein network | https://string-db.org/network/9606.ENSP00000445175 | Lactate dehydrogenase A; Belongs to the LDH/MDH superfamily. LDH family |
| PRR19 protein network | https://string-db.org/network/9606.ENSP00000445247 | Proline-rich protein 19; Proline rich 19 |
| ATP1A1 protein network | https://string-db.org/network/9606.ENSP00000445306 | Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium [...] |
| SLC5A8 protein network | https://string-db.org/network/9606.ENSP00000445340 | Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short [...] |
| ATP8B1 protein network | https://string-db.org/network/9606.ENSP00000445359 | Phospholipid-transporting ATPase IC; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the [...] |
| DND1 protein network | https://string-db.org/network/9606.ENSP00000445366 | Dead end protein homolog 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells (By similarity [...] |
| PIK3C2G protein network | https://string-db.org/network/9606.ENSP00000445381 | Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that [...] |
| OR10G2 protein network | https://string-db.org/network/9606.ENSP00000445383 | Olfactory receptor 10G2; Odorant receptor; Olfactory receptors, family 10 |
| RABEP1 protein network | https://string-db.org/network/9606.ENSP00000445408 | Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling e [...] |
| FAM90A1 protein network | https://string-db.org/network/9606.ENSP00000445418 | Protein FAM90A1; Family with sequence similarity 90 member A1 |
| PHKG1 protein network | https://string-db.org/network/9606.ENSP00000445440 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen b [...] |
| C3orf33 protein network | https://string-db.org/network/9606.ENSP00000445446 | Protein C3orf33; Isoform 2: Secreted protein may play a role in transcription regulation via the MAPK3/MAPK1 pathway through an unidentified receptor on the plasma membrane |
| CNOT4 protein network | https://string-db.org/network/9606.ENSP00000445508 | CCR4-NOT transcription complex subunit 4; Has E3 ubiquitin ligase activity. Involved in activation of the JAK/STAT pathway; CCR4-NOT transcription complex |
| EGR4 protein network | https://string-db.org/network/9606.ENSP00000445626 | Early growth response protein 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required [...] |
| HIST1H2BG protein network | https://string-db.org/network/9606.ENSP00000445633 | Histone cluster 1 H2B family member g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| PRAME protein network | https://string-db.org/network/9606.ENSP00000445675 | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. P [...] |
| GPRASP1 protein network | https://string-db.org/network/9606.ENSP00000445683 | G-protein coupled receptor-associated sorting protein 1; Modulates lysosomal sorting and functional down- regulation of a variety of G-protein coupled receptors. Targets receptors for degradation [...] |
| ANKRD65 protein network | https://string-db.org/network/9606.ENSP00000445688 | Ankyrin repeat domain-containing protein 65; Ankyrin repeat domain containing |
| PCGF5 protein network | https://string-db.org/network/9606.ENSP00000445704 | Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many gene [...] |
| RNF170 protein network | https://string-db.org/network/9606.ENSP00000445725 | E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradatio [...] |
| KIAA1147 protein network | https://string-db.org/network/9606.ENSP00000445768 | Protein LCHN; May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia |
| LTB4R2 protein network | https://string-db.org/network/9606.ENSP00000445772 | Leukotriene B4 receptor 2; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activ [...] |
| FAM216B protein network | https://string-db.org/network/9606.ENSP00000445786 | Protein FAM216B; Family with sequence similarity 216 member B; Belongs to the FAM216 family |
| TIMM50 protein network | https://string-db.org/network/9606.ENSP00000445806 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across th [...] |
| SLC39A11 protein network | https://string-db.org/network/9606.ENSP00000445829 | Zinc transporter ZIP11; Functions as a cellular zinc transporter; Solute carriers |
| HIST2H2BF protein network | https://string-db.org/network/9606.ENSP00000445831 | Histone H2B type 2-F; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| BCL7A protein network | https://string-db.org/network/9606.ENSP00000445868 | B-cell CLL/lymphoma 7 protein family member A; BCL tumor suppressor 7A; BAF complex |
| EVI5L protein network | https://string-db.org/network/9606.ENSP00000445905 | EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity |
| MMAB protein network | https://string-db.org/network/9606.ENSP00000445920 | Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers [...] |
| SLC2A14 protein network | https://string-db.org/network/9606.ENSP00000445929 | Solute carrier family 2, facilitated glucose transporter member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis; Solute carriers |
| ZNF623 protein network | https://string-db.org/network/9606.ENSP00000445979 | Zinc finger protein 623; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| VIM protein network | https://string-db.org/network/9606.ENSP00000446007 | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitoc [...] |
| BEX5 protein network | https://string-db.org/network/9606.ENSP00000446054 | Protein BEX5; Brain expressed X-linked family; Belongs to the BEX family |
| SHD protein network | https://string-db.org/network/9606.ENSP00000446058 | SH2 domain-containing adapter protein D; May function as an adapter protein; SH2 domain containing |
| TUBGCP2 protein network | https://string-db.org/network/9606.ENSP00000446093 | Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome |
| RBMXL1 protein network | https://string-db.org/network/9606.ENSP00000446099 | RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing |
| CMIP protein network | https://string-db.org/network/9606.ENSP00000446100 | C-Maf-inducing protein; Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that [...] |
| C12orf56 protein network | https://string-db.org/network/9606.ENSP00000446101 | Uncharacterized protein C12orf56; Chromosome 12 open reading frame 56 |
| LIMS1 protein network | https://string-db.org/network/9606.ENSP00000446121 | LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface re [...] |
| RRP12 protein network | https://string-db.org/network/9606.ENSP00000446184 | RRP12-like protein; Armadillo-like helical domain containing |
| HES7 protein network | https://string-db.org/network/9606.ENSP00000446205 | Transcription factor HES-7; Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the preso [...] |
| RAN protein network | https://string-db.org/network/9606.ENSP00000446215 | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplas [...] |
| ZNF550 protein network | https://string-db.org/network/9606.ENSP00000446224 | Zinc finger protein 550; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SLC25A10 protein network | https://string-db.org/network/9606.ENSP00000446242 | Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane; Be [...] |
| SOD2 protein network | https://string-db.org/network/9606.ENSP00000446252 | Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems |
| LSM14A protein network | https://string-db.org/network/9606.ENSP00000446271 | Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs; LSm proteins |
| LRTM2 protein network | https://string-db.org/network/9606.ENSP00000446278 | Leucine rich repeats and transmembrane domains 2 |
| PCSK5 protein network | https://string-db.org/network/9606.ENSP00000446280 | Proprotein convertase subtilisin/kexin type 5; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...] |
| ZNF362 protein network | https://string-db.org/network/9606.ENSP00000446335 | Zinc finger protein 362; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GCSAML protein network | https://string-db.org/network/9606.ENSP00000446460 | Germinal center associated signaling and motility like |
| FICD protein network | https://string-db.org/network/9606.ENSP00000446479 | Adenosine monophosphate-protein transferase FICD; Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rh [...] |
| GTSF1 protein network | https://string-db.org/network/9606.ENSP00000446485 | Gametocyte-specific factor 1; Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells |
| COX14 protein network | https://string-db.org/network/9606.ENSP00000446524 | Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cyto [...] |
| HOXC11 protein network | https://string-db.org/network/9606.ENSP00000446680 | Homeobox protein Hox-C11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posteri [...] |
| PCED1B protein network | https://string-db.org/network/9606.ENSP00000446688 | PC-esterase domain containing 1B; Belongs to the PC-esterase family |
| ENSG00000144785 protein network | https://string-db.org/network/9606.ENSP00000446743 | Uncharacterized protein |
| BPNT1 protein network | https://string-db.org/network/9606.ENSP00000446828 | 3'(2'),5'-bisphosphate nucleotidase 1; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 10 [...] |
| DNAJC22 protein network | https://string-db.org/network/9606.ENSP00000446830 | DnaJ homolog subfamily C member 22; May function as a co-chaperone; DNAJ heat shock proteins |
| GATC protein network | https://string-db.org/network/9606.ENSP00000446872 | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. [...] |
| C21orf59-TCP10L protein network | https://string-db.org/network/9606.ENSP00000446874 | Uncharacterized protein |
| BAZ2A protein network | https://string-db.org/network/9606.ENSP00000446880 | Bromodomain adjacent to zinc finger domain protein 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruitin [...] |
| NPIPA2 protein network | https://string-db.org/network/9606.ENSP00000446882 | Nuclear pore complex interacting protein family member A2 |
| NPIPB9 protein network | https://string-db.org/network/9606.ENSP00000446902 | Nuclear pore complex interacting protein family member B9; Belongs to the NPIP family |
| PRSS58 protein network | https://string-db.org/network/9606.ENSP00000446916 | Serine protease 58; Belongs to the peptidase S1 family |
| APPL2 protein network | https://string-db.org/network/9606.ENSP00000446917 | DCC-interacting protein 13-beta; Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal tr [...] |
| MYL6 protein network | https://string-db.org/network/9606.ENSP00000446955 | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing |
| ENSG00000257390 protein network | https://string-db.org/network/9606.ENSP00000447000 | Uncharacterized protein |
| RPL18 protein network | https://string-db.org/network/9606.ENSP00000447001 | 60S ribosomal protein L18; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL18 family |
| CNTN1 protein network | https://string-db.org/network/9606.ENSP00000447006 | Contactin-1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the [...] |
| RAB5C protein network | https://string-db.org/network/9606.ENSP00000447053 | Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); RAB, member RAS oncogene GTPases |
| ENSG00000203546 protein network | https://string-db.org/network/9606.ENSP00000447056 | Uncharacterized protein |
| C12orf45 protein network | https://string-db.org/network/9606.ENSP00000447057 | Uncharacterized protein C12orf45; Chromosome 12 open reading frame 45 |
| SLC8B1 protein network | https://string-db.org/network/9606.ENSP00000447091 | Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ion [...] |
| CHURC1-FNTB protein network | https://string-db.org/network/9606.ENSP00000447121 | cDNA FLJ59570, highly similar to Protein farnesyltransferase subunit beta (EC 2.5.1.58); CHURC1-FNTB readthrough |
| NR1H4 protein network | https://string-db.org/network/9606.ENSP00000447149 | Bile acid receptor; Isoform 4: Promotes transcriptional activation of target genes ABCB11/BSEP (inducible by unconjugated CDCA, ACA and DCA), NR0B2/SHP (inducible by unconjugated CDCA, ACA and DC [...] |
| VDR protein network | https://string-db.org/network/9606.ENSP00000447173 | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms h [...] |
| FRS2 protein network | https://string-db.org/network/9606.ENSP00000447241 | Fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinase [...] |
| RAB3IP protein network | https://string-db.org/network/9606.ENSP00000447300 | Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their [...] |
| MGAM protein network | https://string-db.org/network/9606.ENSP00000447378 | Maltase-glucoamylase, intestinal; May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique ro [...] |
| LOC93432 protein network | https://string-db.org/network/9606.ENSP00000447431 | Probable maltase-glucoamylase 2; Homo sapiens maltase-glucoamylase (alpha-glucosidase) (LOC93432), mRNA |
| LIN7A protein network | https://string-db.org/network/9606.ENSP00000447488 | Protein lin-7 homolog A; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated mu [...] |
| BLOC1S1 protein network | https://string-db.org/network/9606.ENSP00000447537 | Biogenesis of lysosome-related organelles complex 1 subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as plat [...] |
| RT14 protein network | https://string-db.org/network/9606.ENSP00000447650 | Uncharacterized protein; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. I [...] |
| MTERF2 protein network | https://string-db.org/network/9606.ENSP00000447651 | Transcription termination factor 2, mitochondrial; Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species; Belongs to the mTERF family |
| INAFM1 protein network | https://string-db.org/network/9606.ENSP00000447679 | Putative transmembrane protein INAFM1; InaF motif containing 1 |
| CD63 protein network | https://string-db.org/network/9606.ENSP00000447730 | CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leadi [...] |
| TMEM116 protein network | https://string-db.org/network/9606.ENSP00000447731 | Transmembrane protein 116 |
| POC1B-GALNT4 protein network | https://string-db.org/network/9606.ENSP00000447852 | Polypeptide N-acetylgalactosaminyltransferase; POC1B-GALNT4 readthrough |
| ZBED6 protein network | https://string-db.org/network/9606.ENSP00000447879 | Zinc finger BED domain-containing protein 6; Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of othe [...] |
| ZNF878 protein network | https://string-db.org/network/9606.ENSP00000447931 | Zinc finger protein 878; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PFDN5 protein network | https://string-db.org/network/9606.ENSP00000447942 | Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which the [...] |
| CEP290 protein network | https://string-db.org/network/9606.ENSP00000448012 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110. May play a role i [...] |
| NACA protein network | https://string-db.org/network/9606.ENSP00000448035 | Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the developm [...] |
| DAZAP2 protein network | https://string-db.org/network/9606.ENSP00000448051 | DAZ associated protein 2 |
| NUP37 protein network | https://string-db.org/network/9606.ENSP00000448054 | Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex [...] |
| PAH protein network | https://string-db.org/network/9606.ENSP00000448059 | Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. |
| POTEG protein network | https://string-db.org/network/9606.ENSP00000448062 | POTE ankyrin domain family member G; Belongs to the POTE family |
| PRPF40B protein network | https://string-db.org/network/9606.ENSP00000448073 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing |
| TPCN1 protein network | https://string-db.org/network/9606.ENSP00000448083 | Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal [...] |
| APAF1 protein network | https://string-db.org/network/9606.ENSP00000448165 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apopto [...] |
| TBC1D15 protein network | https://string-db.org/network/9606.ENSP00000448182 | TBC1 domain family member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity) |
| TAS2R38 protein network | https://string-db.org/network/9606.ENSP00000448219 | Taste receptor type 2 member 38; Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal [...] |
| KRT4 protein network | https://string-db.org/network/9606.ENSP00000448220 | Keratin, type II cytoskeletal 4; Keratins, type II; Belongs to the intermediate filament family |
| SPATS2 protein network | https://string-db.org/network/9606.ENSP00000448228 | Spermatogenesis-associated serine-rich protein 2; Spermatogenesis associated serine rich 2 |
| GLIPR1L2 protein network | https://string-db.org/network/9606.ENSP00000448248 | GLIPR1-like protein 2; GLI pathogenesis related family 1; Belongs to the CRISP family |
| BEST2 protein network | https://string-db.org/network/9606.ENSP00000448310 | Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Bestrophins |
| BRF1 protein network | https://string-db.org/network/9606.ENSP00000448323 | Transcription factor IIIB 90 kDa subunit; General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters. The isoform 1 is involved in the transc [...] |
| CPM protein network | https://string-db.org/network/9606.ENSP00000448517 | Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth fac [...] |
| C12orf75 protein network | https://string-db.org/network/9606.ENSP00000448536 | Overexpressed in colon carcinoma 1 protein; Chromosome 12 open reading frame 75 |
| SPIC protein network | https://string-db.org/network/9606.ENSP00000448580 | Transcription factor Spi-C; Controls the development of red pulp macrophages required for red blood cells recycling and iron homeostasis. Transcription factor that binds to the PU-box, a purine-r [...] |
| C17orf49 protein network | https://string-db.org/network/9606.ENSP00000448598 | Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes; Myb/SANT domain containing |
| DDIT3 protein network | https://string-db.org/network/9606.ENSP00000448665 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell [...] |
| RITA1 protein network | https://string-db.org/network/9606.ENSP00000448680 | RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediate [...] |
| MAP3K12 protein network | https://string-db.org/network/9606.ENSP00000448689 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. Phosphorylates beta-casein, histone 1 and myelin basic protein in vitro; Belongs to the protein kin [...] |
| DTX3 protein network | https://string-db.org/network/9606.ENSP00000448696 | Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Prob [...] |
| METTL7A protein network | https://string-db.org/network/9606.ENSP00000448785 | Methyltransferase-like protein 7A; Probable methyltransferase |
| OR9A4 protein network | https://string-db.org/network/9606.ENSP00000448789 | Olfactory receptor 9A4; Odorant receptor; Olfactory receptors, family 9 |
| OR6C68 protein network | https://string-db.org/network/9606.ENSP00000448811 | Olfactory receptor 6C68; Odorant receptor; Olfactory receptors, family 6 |
| NPIPA3 protein network | https://string-db.org/network/9606.ENSP00000448841 | Nuclear pore complex interacting protein family member A3; Belongs to the NPIP family |
| GAS2L3 protein network | https://string-db.org/network/9606.ENSP00000448955 | GAS2-like protein 3; Cytoskeletal linker protein. May promote and stabilize the formation of the actin and microtubule network; Belongs to the GAS2 family |
| CYP4F12 protein network | https://string-db.org/network/9606.ENSP00000448998 | Cytochrome P450 4F12; Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the [...] |
| OR11H12 protein network | https://string-db.org/network/9606.ENSP00000449002 | Olfactory receptor 11H12; Odorant receptor; Olfactory receptors, family 11 |
| ENSG00000229117 protein network | https://string-db.org/network/9606.ENSP00000449026 | Ribosomal protein L41; Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII; L ribosomal proteins |
| RDH12 protein network | https://string-db.org/network/9606.ENSP00000449079 | Retinol dehydrogenase 12; Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-tran [...] |
| DNM1L protein network | https://string-db.org/network/9606.ENSP00000449089 | Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the sc [...] |
| C19orf67 protein network | https://string-db.org/network/9606.ENSP00000449137 | UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family |
| ENSG00000258130 protein network | https://string-db.org/network/9606.ENSP00000449223 | Protein LOC101929849 |
| AGAP2 protein network | https://string-db.org/network/9606.ENSP00000449241 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the preve [...] |
| KCNC2 protein network | https://string-db.org/network/9606.ENSP00000449253 | Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes t [...] |
| COPZ1 protein network | https://string-db.org/network/9606.ENSP00000449270 | Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosyn [...] |
| RPLP0 protein network | https://string-db.org/network/9606.ENSP00000449328 | 60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 |
| ENSG00000258150 protein network | https://string-db.org/network/9606.ENSP00000449334 | Uncharacterized protein |
| MAPKAPK5 protein network | https://string-db.org/network/9606.ENSP00000449381 | MAP kinase-activated protein kinase 5; Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MA [...] |
| KRT8 protein network | https://string-db.org/network/9606.ENSP00000449404 | Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type II |
| TWF1 protein network | https://string-db.org/network/9606.ENSP00000449428 | Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also [...] |
| RNASEK protein network | https://string-db.org/network/9606.ENSP00000449500 | Ribonuclease kappa; Endoribonuclease which preferentially cleaves ApU and ApG phosphodiester bonds. Hydrolyzes UpU bonds at a lower rate; Belongs to the RNase K family |
| ACSS3 protein network | https://string-db.org/network/9606.ENSP00000449535 | Acyl-CoA synthetase short-chain family member 3, mitochondrial; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enz [...] |
| ENSG00000257921 protein network | https://string-db.org/network/9606.ENSP00000449544 | Uncharacterized protein |
| ANKS1B protein network | https://string-db.org/network/9606.ENSP00000449629 | Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells; An [...] |
| FKBP11 protein network | https://string-db.org/network/9606.ENSP00000449751 | Peptidyl-prolyl cis-trans isomerase FKBP11; PPIases accelerate the folding of proteins during protein synthesis; FKBP prolyl isomerases |
| SLC38A1 protein network | https://string-db.org/network/9606.ENSP00000449756 | Sodium-coupled neutral amino acid transporter 1; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium [...] |
| ENSG00000257411 protein network | https://string-db.org/network/9606.ENSP00000449770 | Uncharacterized protein |
| HECTD4 protein network | https://string-db.org/network/9606.ENSP00000449784 | Probable E3 ubiquitin-protein ligase HECTD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the [...] |
| TRIAP1 protein network | https://string-db.org/network/9606.ENSP00000449795 | TP53-regulated inhibitor of apoptosis 1; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, t [...] |
| MRPL42 protein network | https://string-db.org/network/9606.ENSP00000449884 | Mitochondrial ribosomal protein L42; Belongs to the mitochondrion-specific ribosomal protein mL42 family |
| CALCOCO1 protein network | https://string-db.org/network/9606.ENSP00000449960 | Calcium-binding and coiled-coil domain-containing protein 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-term [...] |
| CLEC5A protein network | https://string-db.org/network/9606.ENSP00000449999 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. Acts as a key reg [...] |
| ASPG protein network | https://string-db.org/network/9606.ENSP00000450040 | 60 kDa lysophospholipase; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities; In the N-terminal section; belongs to the asparaginase 1 family |
| RNASEK-C17orf49 protein network | https://string-db.org/network/9606.ENSP00000450085 | RNASEK-C17orf49 readthrough |
| C14orf79 protein network | https://string-db.org/network/9606.ENSP00000450114 | Uncharacterized protein CLBA1; Chromosome 14 open reading frame 79 |
| RASAL1 protein network | https://string-db.org/network/9606.ENSP00000450244 | RasGAP-activating-like protein 1; Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes; C2 and RasGAP domain containing |
| ENSG00000111780 protein network | https://string-db.org/network/9606.ENSP00000450281 | Uncharacterized protein; Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial |
| GPR84 protein network | https://string-db.org/network/9606.ENSP00000450310 | G-protein coupled receptor 84; Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the [...] |
| PPFIA2 protein network | https://string-db.org/network/9606.ENSP00000450337 | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at speci [...] |
| ENSG00000257767 protein network | https://string-db.org/network/9606.ENSP00000450353 | Uncharacterized protein |
| MYL6B protein network | https://string-db.org/network/9606.ENSP00000450385 | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium; EF-hand domain containing |
| ALDH6A1 protein network | https://string-db.org/network/9606.ENSP00000450436 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA; Aldehyde dehydrogenases |
| HEATR4 protein network | https://string-db.org/network/9606.ENSP00000450444 | HEAT repeat-containing protein 4; Armadillo-like helical domain containing |
| RAX2 protein network | https://string-db.org/network/9606.ENSP00000450456 | Retina and anterior neural fold homeobox protein 2; May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promote [...] |
| CEP95 protein network | https://string-db.org/network/9606.ENSP00000450461 | Centrosomal protein 95 |
| BDKRB2 protein network | https://string-db.org/network/9606.ENSP00000450482 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 [...] |
| MAP1LC3B2 protein network | https://string-db.org/network/9606.ENSP00000450524 | Microtubule-associated proteins 1A/1B light chain 3 beta 2; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes [...] |
| HOPX protein network | https://string-db.org/network/9606.ENSP00000450527 | Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating th [...] |
| ENSG00000196136 protein network | https://string-db.org/network/9606.ENSP00000450540 | Alpha-1-antichymotrypsin; Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiot [...] |
| IL11RA protein network | https://string-db.org/network/9606.ENSP00000450565 | Interleukin-11 receptor subunit alpha; Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11R [...] |
| RNASE12 protein network | https://string-db.org/network/9606.ENSP00000450580 | Probable inactive ribonuclease-like protein 12; Does not exhibit any ribonuclease activity |
| TIMELESS protein network | https://string-db.org/network/9606.ENSP00000450607 | Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication a [...] |
| ENSG00000258466 protein network | https://string-db.org/network/9606.ENSP00000450614 | annotation not available |
| ENSG00000258973 protein network | https://string-db.org/network/9606.ENSP00000450730 | Uncharacterized protein |
| VTI1B protein network | https://string-db.org/network/9606.ENSP00000450731 | Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are [...] |
| ZFYVE1 protein network | https://string-db.org/network/9606.ENSP00000450742 | Zinc finger FYVE-type containing 1 |
| JKAMP protein network | https://string-db.org/network/9606.ENSP00000450749 | JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) [...] |
| SIPA1L1 protein network | https://string-db.org/network/9606.ENSP00000450832 | Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to [...] |
| SERPINA4 protein network | https://string-db.org/network/9606.ENSP00000450838 | Kallistatin; Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor an [...] |
| TMEM30B protein network | https://string-db.org/network/9606.ENSP00000450842 | Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inne [...] |
| POTEM protein network | https://string-db.org/network/9606.ENSP00000450853 | POTE ankyrin domain family member M |
| ENSG00000259132 protein network | https://string-db.org/network/9606.ENSP00000450856 | annotation not available |
| STON2 protein network | https://string-db.org/network/9606.ENSP00000450857 | Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family |
| SMEK1 protein network | https://string-db.org/network/9606.ENSP00000450864 | Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizin [...] |
| FPGT-TNNI3K protein network | https://string-db.org/network/9606.ENSP00000450895 | FPGT-TNNI3K readthrough; Ankyrin repeat domain containing |
| SLIRP protein network | https://string-db.org/network/9606.ENSP00000450909 | SRA stem-loop-interacting RNA-binding protein, mitochondrial; RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediate [...] |
| TMEM179 protein network | https://string-db.org/network/9606.ENSP00000450958 | Transmembrane protein 179; Belongs to the TMEM179 family |
| EMX2 protein network | https://string-db.org/network/9606.ENSP00000450962 | Homeobox protein EMX2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations [...] |
| DIO2 protein network | https://string-db.org/network/9606.ENSP00000450980 | Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) |
| ZBTB1 protein network | https://string-db.org/network/9606.ENSP00000451000 | Zinc finger and BTB domain-containing protein 1; Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in trans [...] |
| RGS6 protein network | https://string-db.org/network/9606.ENSP00000451030 | Regulator of G-protein signaling 6; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby dr [...] |
| PGF protein network | https://string-db.org/network/9606.ENSP00000451040 | Placenta growth factor; Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 bind [...] |
| ERH protein network | https://string-db.org/network/9606.ENSP00000451080 | Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family |
| DUX4L6 protein network | https://string-db.org/network/9606.ENSP00000451087 | Double homeobox 4 like 6; PRD class homeoboxes and pseudogenes |
| DUX4L5 protein network | https://string-db.org/network/9606.ENSP00000451107 | Double homeobox 4 like 5; PRD class homeoboxes and pseudogenes |
| NPC2 protein network | https://string-db.org/network/9606.ENSP00000451112 | Epididymal secretory protein E1; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compar [...] |
| ENSG00000258724 protein network | https://string-db.org/network/9606.ENSP00000451145 | Uncharacterized protein; Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differen [...] |
| CEP128 protein network | https://string-db.org/network/9606.ENSP00000451162 | Centrosomal protein 128 |
| GSKIP protein network | https://string-db.org/network/9606.ENSP00000451188 | GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signali [...] |
| DUX4L1 protein network | https://string-db.org/network/9606.ENSP00000451207 | Double homeobox 4 like 1; PRD class homeoboxes and pseudogenes |
| NEDD1 protein network | https://string-db.org/network/9606.ENSP00000451211 | Protein NEDD1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle; WD repeat domain containing |
| PROX2 protein network | https://string-db.org/network/9606.ENSP00000451223 | Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival (By similarity); Belongs to the Prospero homeodomain family |
| ENSG00000132716 protein network | https://string-db.org/network/9606.ENSP00000451235 | DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors |
| UBE2J1 protein network | https://string-db.org/network/9606.ENSP00000451261 | Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic re [...] |
| MAP3K9 protein network | https://string-db.org/network/9606.ENSP00000451263 | Mitogen-activated protein kinase kinase kinase 9; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascad [...] |
| DUX4L4 protein network | https://string-db.org/network/9606.ENSP00000451270 | Double homeobox protein 4-like protein 4; May be involved in transcriptional regulation; PRD class homeoboxes and pseudogenes |
| HNRNPC protein network | https://string-db.org/network/9606.ENSP00000451291 | Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the st [...] |
| NUMB protein network | https://string-db.org/network/9606.ENSP00000451300 | Protein numb homolog; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowi [...] |
| C14orf6 protein network | https://string-db.org/network/9606.ENSP00000451318 | Ribonuclease, RNase A family, 11 (non-active); Ribonuclease A family member 11 |
| ENSG00000259066 protein network | https://string-db.org/network/9606.ENSP00000451369 | Uncharacterized protein |
| HSD17B6 protein network | https://string-db.org/network/9606.ENSP00000451406 | 17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid [...] |
| DUX4L7 protein network | https://string-db.org/network/9606.ENSP00000451411 | Double homeobox 4 like 7; PRD class homeoboxes and pseudogenes |
| DUX4L2 protein network | https://string-db.org/network/9606.ENSP00000451545 | Double homeobox 4 like 2; May be involved in transcriptional regulation; PRD class homeoboxes and pseudogenes |
| ENSG00000258947 protein network | https://string-db.org/network/9606.ENSP00000451560 | Uncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha [...] |
| ASB2 protein network | https://string-db.org/network/9606.ENSP00000451575 | Ankyrin repeat and SOCS box protein 2; Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination an [...] |
| MOAP1 protein network | https://string-db.org/network/9606.ENSP00000451594 | Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response [...] |
| MC1R protein network | https://string-db.org/network/9606.ENSP00000451605 | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to th [...] |
| NRXN3 protein network | https://string-db.org/network/9606.ENSP00000451648 | Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling; Neurexins |
| NDRG2 protein network | https://string-db.org/network/9606.ENSP00000451712 | Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor s [...] |
| SPTB protein network | https://string-db.org/network/9606.ENSP00000451752 | Spectrin beta chain, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cyto [...] |
| C6orf174 protein network | https://string-db.org/network/9606.ENSP00000451768 | Protein SOGA3; SOGA family member 3 |
| ENSG00000258728 protein network | https://string-db.org/network/9606.ENSP00000451792 | Uncharacterized protein |
| LIN52 protein network | https://string-db.org/network/9606.ENSP00000451812 | Protein lin-52 homolog; Lin-52 DREAM MuvB core complex component |
| SRP54 protein network | https://string-db.org/network/9606.ENSP00000451818 | Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating me [...] |
| AKT1 protein network | https://string-db.org/network/9606.ENSP00000451828 | RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes includ [...] |
| IFI27L1 protein network | https://string-db.org/network/9606.ENSP00000451851 | Interferon alpha inducible protein 27 like 1 |
| DUX4L3 protein network | https://string-db.org/network/9606.ENSP00000451859 | annotation not available |
| SMIM13 protein network | https://string-db.org/network/9606.ENSP00000451866 | Small integral membrane protein 13 |
| NKX1-2 protein network | https://string-db.org/network/9606.ENSP00000451945 | NK1 transcription factor-related protein 2; May function in cell specification, particularly in the CNS; NKL subclass homeoboxes and pseudogenes |
| OR13A1 protein network | https://string-db.org/network/9606.ENSP00000451950 | Olfactory receptor 13A1; Odorant receptor; Olfactory receptors, family 13 |
| PRAF2 protein network | https://string-db.org/network/9606.ENSP00000451962 | PRA1 family protein 2; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis; YIP family |
| XRCC3 protein network | https://string-db.org/network/9606.ENSP00000451974 | DNA repair protein XRCC3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of [...] |
| EML5 protein network | https://string-db.org/network/9606.ENSP00000451998 | Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; WD repeat domain containing |
| ISCA2 protein network | https://string-db.org/network/9606.ENSP00000452007 | Iron-sulfur cluster assembly 2 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in [...] |
| DNAL1 protein network | https://string-db.org/network/9606.ENSP00000452037 | Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm [...] |
| ITGA7 protein network | https://string-db.org/network/9606.ENSP00000452120 | Integrin alpha-7; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobili [...] |
| SRSF5 protein network | https://string-db.org/network/9606.ENSP00000452123 | Serine/arginine-rich splicing factor 5; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites; RNA binding motif containing |
| RGMA protein network | https://string-db.org/network/9606.ENSP00000452126 | Repulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube cl [...] |
| VIPAS39 protein network | https://string-db.org/network/9606.ENSP00000452181 | Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the ap [...] |
| RNASE4 protein network | https://string-db.org/network/9606.ENSP00000452245 | Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Ribonuclease A family |
| ENSG00000258941 protein network | https://string-db.org/network/9606.ENSP00000452252 | Endoplasmic reticulum export factor CTAGE5; cTAGE family member 5 |
| OR4C13 protein network | https://string-db.org/network/9606.ENSP00000452277 | Olfactory receptor 4C13; Odorant receptor; Olfactory receptors, family 4 |
| PTGR2 protein network | https://string-db.org/network/9606.ENSP00000452280 | Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto- PGE2-alpha with highest activity towards 15-keto- [...] |
| ENSG00000273171 protein network | https://string-db.org/network/9606.ENSP00000452347 | Uncharacterized protein |
| DUXA protein network | https://string-db.org/network/9606.ENSP00000452398 | Double homeobox protein A; Putative transcription factor; PRD class homeoboxes and pseudogenes |
| ENSG00000258989 protein network | https://string-db.org/network/9606.ENSP00000452401 | annotation not available |
| PTPN21 protein network | https://string-db.org/network/9606.ENSP00000452414 | Protein tyrosine phosphatase, non-receptor type 21; FERM domain containing |
| GTF2A1 protein network | https://string-db.org/network/9606.ENSP00000452454 | Transcription initiation factor IIA subunit 1; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a compl [...] |
| BCL2L2-PABPN1 protein network | https://string-db.org/network/9606.ENSP00000452479 | BCL2L2-PABPN1 readthrough; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX |
| NAA30 protein network | https://string-db.org/network/9606.ENSP00000452521 | N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Le [...] |
| ENSG00000258674 protein network | https://string-db.org/network/9606.ENSP00000452549 | Uncharacterized protein; YjeF N-terminal domain-containing protein 3 |
| ZFP37 protein network | https://string-db.org/network/9606.ENSP00000452552 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| TNFAIP2 protein network | https://string-db.org/network/9606.ENSP00000452634 | Tumor necrosis factor alpha-induced protein 2; May play a role as a mediator of inflammation and angiogenesis |
| SEC11A protein network | https://string-db.org/network/9606.ENSP00000452697 | Signal peptidase complex catalytic subunit SEC11A; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen [...] |
| PSTPIP1 protein network | https://string-db.org/network/9606.ENSP00000452746 | Proline-serine-threonine phosphatase-interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PT [...] |
| ETFA protein network | https://string-db.org/network/9606.ENSP00000452762 | Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehy [...] |
| C15orf57 protein network | https://string-db.org/network/9606.ENSP00000452773 | Coiled-coil domain-containing protein 32; Chromosome 15 open reading frame 57 |
| B2M protein network | https://string-db.org/network/9606.ENSP00000452780 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis Es [...] |
| ITGB3 protein network | https://string-db.org/network/9606.ENSP00000452786 | Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitr [...] |
| GDPGP1 protein network | https://string-db.org/network/9606.ENSP00000452793 | GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells |
| PEAK1 protein network | https://string-db.org/network/9606.ENSP00000452796 | Pseudopodium-enriched atypical kinase 1; Tyrosine kinase that may play a role in cell spreading and migration on fibronectin. May directly or indirectly affect phosphorylation levels of cytoskele [...] |
| TLE3 protein network | https://string-db.org/network/9606.ENSP00000452871 | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members [...] |
| ZNF592 protein network | https://string-db.org/network/9606.ENSP00000452877 | Zinc finger protein 592; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| FAM63B protein network | https://string-db.org/network/9606.ENSP00000452885 | Ubiquitin carboxyl-terminal hydrolase MINDY-2; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Binds to polyubiquitin chains of different linkage types, including 'L [...] |
| RPL28 protein network | https://string-db.org/network/9606.ENSP00000452909 | 60S ribosomal protein L28; Component of the large ribosomal subunit; Belongs to the eukaryotic ribosomal protein eL28 family |
| MAN2A2 protein network | https://string-db.org/network/9606.ENSP00000452948 | Alpha-mannosidase 2x; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N- [...] |
| UBE2Q2L protein network | https://string-db.org/network/9606.ENSP00000453012 | Putative ubiquitin-conjugating enzyme E2Q2-like protein; Ubiquitin conjugating enzyme E2 Q2 like; Belongs to the ubiquitin-conjugating enzyme family |
| C9orf69 protein network | https://string-db.org/network/9606.ENSP00000453019 | Transmembrane protein 250; May play a role in cell proliferation by promoting progression into S phase |
| GPR176 protein network | https://string-db.org/network/9606.ENSP00000453076 | G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repre [...] |
| ENSG00000259371 protein network | https://string-db.org/network/9606.ENSP00000453089 | annotation not available |
| GALK2 protein network | https://string-db.org/network/9606.ENSP00000453129 | N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free Gal [...] |
| BLID protein network | https://string-db.org/network/9606.ENSP00000453153 | BH3-like motif-containing cell death inducer; Functions as a proapoptotic molecule through the caspase-dependent mitochondrial pathway of cell death |
| RGPD1 protein network | https://string-db.org/network/9606.ENSP00000453170 | RANBP2-like and GRIP domain-containing protein 1; Tetratricopeptide repeat domain containing |
| TRIM69 protein network | https://string-db.org/network/9606.ENSP00000453177 | E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Ring finger proteins |
| LRRC49 protein network | https://string-db.org/network/9606.ENSP00000453273 | Leucine-rich repeat-containing protein 49; Leucine rich repeat containing 49 |
| RFX7 protein network | https://string-db.org/network/9606.ENSP00000453281 | DNA-binding protein RFX7; Regulatory factor X family; Belongs to the RFX family |
| APBA2 protein network | https://string-db.org/network/9606.ENSP00000453293 | Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machi [...] |
| ADAM8 protein network | https://string-db.org/network/9606.ENSP00000453302 | Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes; ADAM metallopeptidase domain containing |
| MEIS3 protein network | https://string-db.org/network/9606.ENSP00000453307 | Homeobox protein Meis3; TALE class homeoboxes and pseudogenes |
| HCG27 protein network | https://string-db.org/network/9606.ENSP00000453364 | HLA complex group 27 |
| TMEM185B protein network | https://string-db.org/network/9606.ENSP00000453399 | Transmembrane protein 185B |
| NUSAP1 protein network | https://string-db.org/network/9606.ENSP00000453403 | Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules (By similarity). May associate with chromosomes and promote the o [...] |
| ST20 protein network | https://string-db.org/network/9606.ENSP00000453502 | Suppressor of tumorigenicity 20 protein; May act as a tumor suppressor. Promotes apoptosis of cancer cells |
| TLN2 protein network | https://string-db.org/network/9606.ENSP00000453508 | Talin-2; As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and [...] |
| FAM169B protein network | https://string-db.org/network/9606.ENSP00000453554 | Protein FAM169B; Family with sequence similarity 169 member B; Belongs to the FAM169 family |
| TGIF2LX protein network | https://string-db.org/network/9606.ENSP00000453704 | Homeobox protein TGIF2LX; May have a transcription role in testis; TALE class homeoboxes and pseudogenes |
| MEIS2 protein network | https://string-db.org/network/9606.ENSP00000453793 | Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabiliz [...] |
| SECISBP2L protein network | https://string-db.org/network/9606.ENSP00000453854 | Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into [...] |
| ENSG00000137843 protein network | https://string-db.org/network/9606.ENSP00000453858 | Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR [...] |
| RNF111 protein network | https://string-db.org/network/9606.ENSP00000453872 | E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional respons [...] |
| CCDC175 protein network | https://string-db.org/network/9606.ENSP00000453940 | Coiled-coil domain containing 175 |
| TMEM253 protein network | https://string-db.org/network/9606.ENSP00000453962 | Transmembrane protein 253 |
| C15orf52 protein network | https://string-db.org/network/9606.ENSP00000453969 | Uncharacterized protein C15orf52; Chromosome 15 open reading frame 52 |
| UBAP1L protein network | https://string-db.org/network/9606.ENSP00000454012 | Ubiquitin-associated protein 1-like; Ubiquitin associated protein 1 like |
| SHISA9 protein network | https://string-db.org/network/9606.ENSP00000454014 | Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA re [...] |
| TGIF2-C20orf24 protein network | https://string-db.org/network/9606.ENSP00000454021 | TGIF2-C20orf24 readthrough |
| GMPR2 protein network | https://string-db.org/network/9606.ENSP00000454038 | GMP reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, a [...] |
| NRL protein network | https://string-db.org/network/9606.ENSP00000454062 | Neural retina-specific leucine zipper protein; Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a trans [...] |
| LDLR protein network | https://string-db.org/network/9606.ENSP00000454071 | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand co [...] |
| C5orf63 protein network | https://string-db.org/network/9606.ENSP00000454153 | Glutaredoxin-like protein C5orf63; Chromosome 5 open reading frame 63 |
| ZEB2 protein network | https://string-db.org/network/9606.ENSP00000454157 | Zinc finger E-box-binding homeobox 2; Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin; ZF class homeoboxes and pse [...] |
| TRAF3 protein network | https://string-db.org/network/9606.ENSP00000454207 | TNF receptor-associated factor 3; Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pat [...] |
| CLN3 protein network | https://string-db.org/network/9606.ENSP00000454229 | Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes |
| NUB1 protein network | https://string-db.org/network/9606.ENSP00000454264 | NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation o [...] |
| KIAA1024L protein network | https://string-db.org/network/9606.ENSP00000454268 | UPF0258 protein KIAA1024-like; KIAA1024 like |
| AP5B1 protein network | https://string-db.org/network/9606.ENSP00000454303 | AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport; Armadillo-like helical domain containing |
| GOLGA8F protein network | https://string-db.org/network/9606.ENSP00000454322 | Golgin A8 family member F; Belongs to the GOLGA8 family |
| ENSG00000261130 protein network | https://string-db.org/network/9606.ENSP00000454340 | Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family |
| SMKR1 protein network | https://string-db.org/network/9606.ENSP00000454370 | Small lysine rich protein 1 |
| FAM173A protein network | https://string-db.org/network/9606.ENSP00000454380 | Protein FAM173A; Seven-beta-strand methyltransferase motif containing |
| ENSG00000131152 protein network | https://string-db.org/network/9606.ENSP00000454386 | annotation not available |
| TMEM170A protein network | https://string-db.org/network/9606.ENSP00000454404 | Transmembrane protein 170A; Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet format [...] |
| GOLGA6L2 protein network | https://string-db.org/network/9606.ENSP00000454407 | Golgin subfamily A member 6-like protein 2; Golgin A6 family-like 2; Belongs to the GOLGA6 family |
| ENSG00000260861 protein network | https://string-db.org/network/9606.ENSP00000454437 | Uncharacterized protein |
| TMEM249 protein network | https://string-db.org/network/9606.ENSP00000454468 | Transmembrane protein 249 |
| ENSG00000260371 protein network | https://string-db.org/network/9606.ENSP00000454500 | Uncharacterized protein |
| RBM15B protein network | https://string-db.org/network/9606.ENSP00000454545 | Putative RNA-binding protein 15B; May function in the regulation of alternative or illicit splicing; Belongs to the RRM Spen family |
| C8orf88 protein network | https://string-db.org/network/9606.ENSP00000454561 | Uncharacterized protein C8orf88; Chromosome 8 open reading frame 88 |
| DNASE1L2 protein network | https://string-db.org/network/9606.ENSP00000454562 | Deoxyribonuclease-1-like 2; Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune rol [...] |
| ITGAX protein network | https://string-db.org/network/9606.ENSP00000454623 | Integrin alpha-X; Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is espe [...] |
| SLC38A7 protein network | https://string-db.org/network/9606.ENSP00000454646 | Putative sodium-coupled neutral amino acid transporter 7; Mediates sodium-dependent transport of amino acids, preferentially L-glutamine; Belongs to the amino acid/polyamine transporter 2 family |
| C16orf97 protein network | https://string-db.org/network/9606.ENSP00000454664 | Uncharacterized protein C16orf97; Chromosome 16 open reading frame 97 |
| ENSG00000260537 protein network | https://string-db.org/network/9606.ENSP00000454699 | ATP-dependent RNA helicase DDX19B |
| ENSG00000260342 protein network | https://string-db.org/network/9606.ENSP00000454746 | Uncharacterized protein |
| LRRC9 protein network | https://string-db.org/network/9606.ENSP00000454748 | Leucine-rich repeat-containing protein 9; Leucine rich repeat containing 9 |
| ANKRD66 protein network | https://string-db.org/network/9606.ENSP00000454770 | Ankyrin repeat domain-containing protein 66; Ankyrin repeat domain containing |
| CORO2B protein network | https://string-db.org/network/9606.ENSP00000454783 | Coronin-2B; May play a role in the reorganization of neuronal actin structure; Belongs to the WD repeat coronin family |
| ENSG00000260836 protein network | https://string-db.org/network/9606.ENSP00000454786 | annotation not available |
| ASIP protein network | https://string-db.org/network/9606.ENSP00000454804 | Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-reg [...] |
| TBL3 protein network | https://string-db.org/network/9606.ENSP00000454836 | Transducin beta-like protein 3; WD repeat domain containing; UTPb subcomplex |
| SNUPN protein network | https://string-db.org/network/9606.ENSP00000454852 | Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-ca [...] |
| C3orf84 protein network | https://string-db.org/network/9606.ENSP00000454903 | Uncharacterized protein C3orf84; Chromosome 3 open reading frame 84 |
| RNF112 protein network | https://string-db.org/network/9606.ENSP00000454919 | E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neur [...] |
| C16orf52 protein network | https://string-db.org/network/9606.ENSP00000454926 | Uncharacterized protein C16orf52; Chromosome 16 open reading frame 52 |
| TMEM204 protein network | https://string-db.org/network/9606.ENSP00000454945 | Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens |
| SCAPER protein network | https://string-db.org/network/9606.ENSP00000454973 | S phase cyclin A-associated protein in the endoplasmic reticulum; CCNA2/CDK2 regulatory protein that transiently maintains CCNA2 in the cytoplasm; Zinc fingers C2H2-type |
| RPUSD1 protein network | https://string-db.org/network/9606.ENSP00000455026 | RNA pseudouridylate synthase domain containing 1; Belongs to the pseudouridine synthase RluA family |
| TMC7 protein network | https://string-db.org/network/9606.ENSP00000455041 | Transmembrane channel-like protein 7; Probable ion channel; Transmembrane channel likes |
| ENSG00000260170 protein network | https://string-db.org/network/9606.ENSP00000455047 | Uncharacterized protein |
| SLC7A6 protein network | https://string-db.org/network/9606.ENSP00000455064 | Y+L amino acid transporter 2; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to [...] |
| METRN protein network | https://string-db.org/network/9606.ENSP00000455068 | Meteorin; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. A [...] |
| C16orf95 protein network | https://string-db.org/network/9606.ENSP00000455079 | Uncharacterized protein C16orf95; Chromosome 16 open reading frame 95 |
| TMEM88B protein network | https://string-db.org/network/9606.ENSP00000455099 | Transmembrane protein 88B |
| BOP1 protein network | https://string-db.org/network/9606.ENSP00000455106 | Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the WD repeat BOP1/ [...] |
| ENSG00000205457 protein network | https://string-db.org/network/9606.ENSP00000455132 | TP53 target 3C; May play a significant role in p53/TP53-mediating signaling pathway |
| NETO2 protein network | https://string-db.org/network/9606.ENSP00000455169 | Neuropilin and tolloid-like protein 2; Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetic [...] |
| GPR56 protein network | https://string-db.org/network/9606.ENSP00000455215 | Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell- cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cell [...] |
| DUS2 protein network | https://string-db.org/network/9606.ENSP00000455229 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the ac [...] |
| TAF1C protein network | https://string-db.org/network/9606.ENSP00000455265 | TATA box-binding protein-associated factor RNA polymerase I subunit C; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation comple [...] |
| GOLGA8S protein network | https://string-db.org/network/9606.ENSP00000455298 | Golgin A8 family member S |
| MKRN2OS protein network | https://string-db.org/network/9606.ENSP00000455385 | MKRN2 opposite strand |
| C15orf41 protein network | https://string-db.org/network/9606.ENSP00000455397 | Uncharacterized protein C15orf41; Chromosome 15 open reading frame 41 |
| ZNF423 protein network | https://string-db.org/network/9606.ENSP00000455426 | Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associat [...] |
| RD3L protein network | https://string-db.org/network/9606.ENSP00000455434 | Protein RD3-like; Retinal degeneration 3-like |
| NUPR1L protein network | https://string-db.org/network/9606.ENSP00000455442 | Nuclear protein 2; Acts as a transcriptional repressor by inhibiting gene expression at the NUPR1 promoter in a p53/TP53-dependent manner in cancer cells. Involved in the G1 cell cycle arrest, an [...] |
| TCF24 protein network | https://string-db.org/network/9606.ENSP00000455444 | Transcription factor 24; Putative transcription factor; Basic helix-loop-helix proteins |
| HYKK protein network | https://string-db.org/network/9606.ENSP00000455459 | Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5- hydroxy-L-lysine |
| GJE1 protein network | https://string-db.org/network/9606.ENSP00000455469 | Putative gap junction epsilon-1 protein; Mediates calcium-independent ATP release, suggesting activity as a hemichannel. Does not form functional gap junctions; Belongs to the connexin family. Be [...] |
| OBSCN protein network | https://string-db.org/network/9606.ENSP00000455507 | Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; Fibronectin type III domain containing |
| OBBP2 protein network | https://string-db.org/network/9606.ENSP00000455510 | Sialic acid binding Ig-like lectin 5; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sial [...] |
| ENSG00000260272 protein network | https://string-db.org/network/9606.ENSP00000455547 | Uncharacterized protein |
| ENSG00000259784 protein network | https://string-db.org/network/9606.ENSP00000455561 | Uncharacterized protein |
| ZNF853 protein network | https://string-db.org/network/9606.ENSP00000455585 | Zinc finger protein 853; Zinc fingers C2H2-type |
| TP53TG3D protein network | https://string-db.org/network/9606.ENSP00000455596 | TP53 target 3D; May play a significant role in p53/TP53-mediating signaling pathway |
| PHKG2 protein network | https://string-db.org/network/9606.ENSP00000455607 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown [...] |
| ARPP19 protein network | https://string-db.org/network/9606.ENSP00000455625 | cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically [...] |
| ST20-MTHFS protein network | https://string-db.org/network/9606.ENSP00000455643 | 5-formyltetrahydrofolate cyclo-ligase; ST20-MTHFS readthrough; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family |
| ENSG00000260869 protein network | https://string-db.org/network/9606.ENSP00000455659 | Uncharacterized protein |
| STMND1 protein network | https://string-db.org/network/9606.ENSP00000455698 | Stathmin domain containing 1 |
| SCRT1 protein network | https://string-db.org/network/9606.ENSP00000455711 | Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG. Can modulate the action of basic helix-loop-helix (bHLH) transcription factors, critical for neuronal [...] |
| ENSG00000158427 protein network | https://string-db.org/network/9606.ENSP00000455771 | Thymosin beta 15B |
| KCTD13 protein network | https://string-db.org/network/9606.ENSP00000455785 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic trans [...] |
| LY6L protein network | https://string-db.org/network/9606.ENSP00000455811 | Lymphocyte antigen 6L; Protein LOC101928108 |
| GOLGA8T protein network | https://string-db.org/network/9606.ENSP00000455826 | Golgin A8 family member T |
| TEX38 protein network | https://string-db.org/network/9606.ENSP00000455854 | Testis-expressed protein 38; Testis expressed 38 |
| MRC1 protein network | https://string-db.org/network/9606.ENSP00000455897 | Macrophage mannose receptor 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains; C-type lectin domain containing |
| MUC22 protein network | https://string-db.org/network/9606.ENSP00000455906 | Mucin-22; Mucin 22; Mucins |
| CLEC19A protein network | https://string-db.org/network/9606.ENSP00000455948 | C-type lectin domain containing 19A |
| FAM229A protein network | https://string-db.org/network/9606.ENSP00000455971 | Protein FAM229A; Family with sequence similarity 229 member A; Belongs to the FAM229 family |
| SMLR1 protein network | https://string-db.org/network/9606.ENSP00000456026 | Small leucine rich protein 1 |
| TUBB8 protein network | https://string-db.org/network/9606.ENSP00000456206 | Tubulin beta-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha ch [...] |
| PRRT2 protein network | https://string-db.org/network/9606.ENSP00000456226 | Interferon induced transmembrane protein domain containing; Belongs to the CD225/Dispanin family |
| C15orf65 protein network | https://string-db.org/network/9606.ENSP00000456337 | Uncharacterized protein C15orf65; Chromosome 15 open reading frame 65 |
| DET1 protein network | https://string-db.org/network/9606.ENSP00000456340 | DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiqui [...] |
| PARP6 protein network | https://string-db.org/network/9606.ENSP00000456348 | poly(ADP-ribose) polymerase family member 6 |
| GOLGA8J protein network | https://string-db.org/network/9606.ENSP00000456401 | Golgin A8 family member J; Belongs to the GOLGA8 family |
| MLST8 protein network | https://string-db.org/network/9606.ENSP00000456405 | Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response [...] |
| SNX29 protein network | https://string-db.org/network/9606.ENSP00000456480 | Sorting nexin 29 |
| ELFN1 protein network | https://string-db.org/network/9606.ENSP00000456548 | Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitator [...] |
| RNF151 protein network | https://string-db.org/network/9606.ENSP00000456566 | RING finger protein 151; May be involved in acrosome formation of spermatids; Ring finger proteins |
| TMEM178B protein network | https://string-db.org/network/9606.ENSP00000456594 | Transmembrane protein 178B |
| STRA6 protein network | https://string-db.org/network/9606.ENSP00000456609 | Receptor for retinol uptake STRA6; Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell m [...] |
| KLHL36 protein network | https://string-db.org/network/9606.ENSP00000456743 | Kelch-like protein 36; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; [...] |
| ZDHHC7 protein network | https://string-db.org/network/9606.ENSP00000456782 | Palmitoyltransferase; Zinc finger DHHC-type containing 7; Belongs to the DHHC palmitoyltransferase family |
| THEGL protein network | https://string-db.org/network/9606.ENSP00000456850 | Testicular haploid expressed gene protein-like; Theg spermatid protein like |
| TBC1D3G protein network | https://string-db.org/network/9606.ENSP00000456861 | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| LOC100509620 protein network | https://string-db.org/network/9606.ENSP00000456868 | Belongs to the MIP/aquaporin (TC 1.A.8) family. |
| GOLGA8M protein network | https://string-db.org/network/9606.ENSP00000456927 | Golgin A8 family member M |
| POTEB2 protein network | https://string-db.org/network/9606.ENSP00000456953 | POTE ankyrin domain family member B2; Belongs to the POTE family |
| INO80E protein network | https://string-db.org/network/9606.ENSP00000457016 | INO80 complex subunit E; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair |
| SZT2 protein network | https://string-db.org/network/9606.ENSP00000457168 | KICSTOR complex protein SZT2; As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 c [...] |
| C15orf59 protein network | https://string-db.org/network/9606.ENSP00000457205 | UPF0583 protein C15orf59; Chromosome 15 open reading frame 59 |
| SPSB3 protein network | https://string-db.org/network/9606.ENSP00000457206 | SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the u [...] |
| WWOX protein network | https://string-db.org/network/9606.ENSP00000457230 | WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergis [...] |
| TSNAXIP1 protein network | https://string-db.org/network/9606.ENSP00000457241 | Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis |
| NOL3 protein network | https://string-db.org/network/9606.ENSP00000457243 | Nucleolar protein 3; Isoform 1: May be involved in RNA splicing; Caspase recruitment domain containing |
| OGFOD1 protein network | https://string-db.org/network/9606.ENSP00000457258 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency [...] |
| EME2 protein network | https://string-db.org/network/9606.ENSP00000457353 | Probable crossover junction endonuclease EME2; Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures; Belongs to the EME1/MMS4 fam [...] |
| CEMP1 protein network | https://string-db.org/network/9606.ENSP00000457380 | Cementoblastoma-derived protein 1; May play a role in development of the periodontium which surrounds and supports the teeth by promoting the differentiation of multi-potent cells from the period [...] |
| SMIM1 protein network | https://string-db.org/network/9606.ENSP00000457386 | Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family |
| KIAA0513 protein network | https://string-db.org/network/9606.ENSP00000457408 | Uncharacterized protein KIAA0513; KIAA0513 |
| USP10 protein network | https://string-db.org/network/9606.ENSP00000457411 | Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 st [...] |
| PECAM1 protein network | https://string-db.org/network/9606.ENSP00000457421 | Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical r [...] |
| CHD9 protein network | https://string-db.org/network/9606.ENSP00000457466 | Chromodomain-helicase-DNA-binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has [...] |
| TMEM219 protein network | https://string-db.org/network/9606.ENSP00000457492 | Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding |
| CCDC179 protein network | https://string-db.org/network/9606.ENSP00000457511 | Coiled-coil domain containing 179 |
| COX4I1 protein network | https://string-db.org/network/9606.ENSP00000457513 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transp [...] |
| APOBR protein network | https://string-db.org/network/9606.ENSP00000457539 | Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic [...] |
| NFAT5 protein network | https://string-db.org/network/9606.ENSP00000457593 | Nuclear factor of activated T-cells 5; Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional respon [...] |
| DBNDD1 protein network | https://string-db.org/network/9606.ENSP00000457625 | Dysbindin domain containing 1 |
| ENSG00000261717 protein network | https://string-db.org/network/9606.ENSP00000457654 | Uncharacterized protein |
| ENSG00000233917 protein network | https://string-db.org/network/9606.ENSP00000457689 | POTE ankyrin domain family member B; Belongs to the POTE family |
| LOC730098 protein network | https://string-db.org/network/9606.ENSP00000457701 | HCG2040265, isoform CRA_a; Uncharacterized protein; cDNA FLJ50015 |
| UBL7 protein network | https://string-db.org/network/9606.ENSP00000457703 | Ubiquitin-like protein 7; Ubiquitin like 7 |
| ENSG00000256825 protein network | https://string-db.org/network/9606.ENSP00000457704 | Zinc finger protein 268 |
| ENSG00000272617 protein network | https://string-db.org/network/9606.ENSP00000457718 | Conserved oligomeric Golgi complex subunit 8 |
| RNPS1 protein network | https://string-db.org/network/9606.ENSP00000457723 | RNA-binding protein with serine-rich domain 1; Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) d [...] |
| SLC25A24 protein network | https://string-db.org/network/9606.ENSP00000457733 | Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, [...] |
| RGSL1 protein network | https://string-db.org/network/9606.ENSP00000457748 | Regulator of G protein signaling like 1 |
| MAN2C1 protein network | https://string-db.org/network/9606.ENSP00000457788 | Alpha-mannosidase 2C1; Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm; Belongs to [...] |
| KCNJ18 protein network | https://string-db.org/network/9606.ENSP00000457807 | Inward rectifier potassium channel 18; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...] |
| CENPT protein network | https://string-db.org/network/9606.ENSP00000457810 | Centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segre [...] |
| OST4 protein network | https://string-db.org/network/9606.ENSP00000457935 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4; Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligos [...] |
| TGFBR3L protein network | https://string-db.org/network/9606.ENSP00000457962 | Transforming growth factor-beta receptor type 3-like protein; Transforming growth factor beta receptor 3 like |
| PHLPP2 protein network | https://string-db.org/network/9606.ENSP00000457991 | PH domain leucine-rich repeat-containing protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobi [...] |
| HSPB9 protein network | https://string-db.org/network/9606.ENSP00000458018 | Heat shock protein family B member 9 |
| DUX4 protein network | https://string-db.org/network/9606.ENSP00000458065 | Double homeobox protein 4; Involved in transcriptional regulation. May regulate microRNA (miRNA) expression; Belongs to the paired homeobox family |
| BOLA2-SMG1P6 protein network | https://string-db.org/network/9606.ENSP00000458075 | BOLA2-SMG1P6 readthrough; BolA-like protein 2 |
| GOLGA8G protein network | https://string-db.org/network/9606.ENSP00000458130 | Golgin A8 family member G; Belongs to the GOLGA8 family |
| ACTG1 protein network | https://string-db.org/network/9606.ENSP00000458162 | Actin, cytoplasmic 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family |
| METTL4 protein network | https://string-db.org/network/9606.ENSP00000458290 | N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)- methylade [...] |
| INCA1 protein network | https://string-db.org/network/9606.ENSP00000458316 | Protein INCA1; Inhibitor of CDK, cyclin A1 interacting protein 1; Belongs to the INCA family |
| DNAH2 protein network | https://string-db.org/network/9606.ENSP00000458355 | Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| CTRL protein network | https://string-db.org/network/9606.ENSP00000458537 | Chymotrypsin-like protease CTRL-1; Chymotrypsin like; Belongs to the peptidase S1 family |
| PCDHGA4 protein network | https://string-db.org/network/9606.ENSP00000458570 | Protocadherin gamma-A4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| MMP12 protein network | https://string-db.org/network/9606.ENSP00000458585 | Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for [...] |
| CIC protein network | https://string-db.org/network/9606.ENSP00000458663 | Protein capicua homolog; Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development |
| CARD14 protein network | https://string-db.org/network/9606.ENSP00000458715 | Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms [...] |
| NMRAL1 protein network | https://string-db.org/network/9606.ENSP00000458762 | NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NAD [...] |
| NDUFAB1 protein network | https://string-db.org/network/9606.ENSP00000458770 | Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respirat [...] |
| GPR139 protein network | https://string-db.org/network/9606.ENSP00000458791 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway; G protein-coupled receptors, Class A orphans |
| ALOX15 protein network | https://string-db.org/network/9606.ENSP00000458832 | Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioa [...] |
| ENSG00000263264 protein network | https://string-db.org/network/9606.ENSP00000458866 | annotation not available |
| NUP88 protein network | https://string-db.org/network/9606.ENSP00000458954 | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex; Nucleoporins |
| DPEP2 protein network | https://string-db.org/network/9606.ENSP00000458977 | Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) |
| CLUH protein network | https://string-db.org/network/9606.ENSP00000458986 | Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in th [...] |
| OR1D5 protein network | https://string-db.org/network/9606.ENSP00000459028 | Olfactory receptor 1D5; Odorant receptor; Olfactory receptors, family 1 |
| CCDC64B protein network | https://string-db.org/network/9606.ENSP00000459043 | BICD family-like cargo adapter 2; Coiled-coil domain containing 64B |
| ZNF578 protein network | https://string-db.org/network/9606.ENSP00000459216 | Zinc finger protein 578; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| GFY protein network | https://string-db.org/network/9606.ENSP00000459439 | Golgi-associated olfactory signaling regulator; Required for proper function of the olfactory system. May be involved in establishing the acuity of olfactory sensory signaling (By similarity) |
| ACSM2A protein network | https://string-db.org/network/9606.ENSP00000459451 | Acyl-coenzyme A synthetase ACSM2A, mitochondrial; Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the correspo [...] |
| LITAF protein network | https://string-db.org/network/9606.ENSP00000459533 | Lipopolysaccharide-induced tumor necrosis factor-alpha factor; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocyt [...] |
| LRRC37A2 protein network | https://string-db.org/network/9606.ENSP00000459551 | Leucine-rich repeat-containing protein 37A2; Leucine rich repeat containing 37 member A2 |
| ZNF75A protein network | https://string-db.org/network/9606.ENSP00000459566 | Zinc finger protein 75A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SPATA22 protein network | https://string-db.org/network/9606.ENSP00000459580 | Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I |
| SRGAP2 protein network | https://string-db.org/network/9606.ENSP00000459615 | SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Play [...] |
| TNK1 protein network | https://string-db.org/network/9606.ENSP00000459799 | Non-receptor tyrosine-protein kinase TNK1; Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function [...] |
| ANKFY1 protein network | https://string-db.org/network/9606.ENSP00000459943 | Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin- [...] |
| TRPV1 protein network | https://string-db.org/network/9606.ENSP00000459962 | Transient receptor potential cation channel, subfamily V, member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. S [...] |
| GTF2I protein network | https://string-db.org/network/9606.ENSP00000460070 | General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal resp [...] |
| SPON1 protein network | https://string-db.org/network/9606.ENSP00000460236 | Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in [...] |
| PCDHGA9 protein network | https://string-db.org/network/9606.ENSP00000460274 | Protocadherin gamma-A9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| PRPF8 protein network | https://string-db.org/network/9606.ENSP00000460348 | Pre-mRNA-processing-splicing factor 8; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. [...] |
| OCLM protein network | https://string-db.org/network/9606.ENSP00000460371 | Oculomedin |
| USP6 protein network | https://string-db.org/network/9606.ENSP00000460380 | Ubiquitin carboxyl-terminal hydrolase 6; Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In v [...] |
| ZFP90 protein network | https://string-db.org/network/9606.ENSP00000460547 | Zinc finger protein 90 homolog; Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes; Zinc fingers C2H [...] |
| ERVMER34-1 protein network | https://string-db.org/network/9606.ENSP00000460602 | Endogenous retrovirus group MER34 member 1 Env polyprotein; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may [...] |
| CCER2 protein network | https://string-db.org/network/9606.ENSP00000460665 | Coiled-coil glutamate rich protein 2 |
| TOM1L1 protein network | https://string-db.org/network/9606.ENSP00000460823 | TOM1-like protein 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activ [...] |
| WSCD1 protein network | https://string-db.org/network/9606.ENSP00000460825 | WSC domain containing 1 |
| CLUAP1 protein network | https://string-db.org/network/9606.ENSP00000460850 | Clusterin-associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling |
| RSL1D1 protein network | https://string-db.org/network/9606.ENSP00000460871 | Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage; Belongs to the univers [...] |
| CORO7-PAM16 protein network | https://string-db.org/network/9606.ENSP00000460885 | Belongs to the WD repeat coronin family. |
| ATPAF1 protein network | https://string-db.org/network/9606.ENSP00000460964 | ATP synthase mitochondrial F1 complex assembly factor 1; May play an essential role for the assembly of the mitochondrial F1-F0 complex |
| ZP2 protein network | https://string-db.org/network/9606.ENSP00000460971 | Zona pellucida sperm-binding protein 2; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy [...] |
| VR1 protein network | https://string-db.org/network/9606.ENSP00000461007 | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. See [...] |
| SCIMP protein network | https://string-db.org/network/9606.ENSP00000461269 | SLP adapter and CSK-interacting membrane protein; Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. R [...] |
| ENSG00000260914 protein network | https://string-db.org/network/9606.ENSP00000461295 | Uncharacterized protein; Belongs to the AAA ATPase family |
| ENSG00000262660 protein network | https://string-db.org/network/9606.ENSP00000461324 | Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane |
| SLC43A2 protein network | https://string-db.org/network/9606.ENSP00000461382 | Large neutral amino acids transporter small subunit 4; Sodium-, chloride-, and pH-independent high affinity transport of large neutral amino acids; Belongs to the SLC43A transporter (TC 2.A.1.44) [...] |
| TRIM16L protein network | https://string-db.org/network/9606.ENSP00000461386 | Tripartite motif-containing protein 16-like protein; Tripartite motif containing 16 like; Belongs to the TRIM/RBCC family |
| OVCA2 protein network | https://string-db.org/network/9606.ENSP00000461388 | OVCA2, serine hydrolase domain containing; Belongs to the LovG family |
| ZNF286B protein network | https://string-db.org/network/9606.ENSP00000461413 | Putative zinc finger protein 286B; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF66 protein network | https://string-db.org/network/9606.ENSP00000461425 | Putative zinc finger protein 66; May be involved in transcriptional regulation |
| FAM195B protein network | https://string-db.org/network/9606.ENSP00000461433 | Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds [...] |
| CTDNEP1 protein network | https://string-db.org/network/9606.ENSP00000461749 | CTD nuclear envelope phosphatase 1; Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 [...] |
| RAB40B protein network | https://string-db.org/network/9606.ENSP00000461785 | Ras-related protein Rab-40B; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequ [...] |
| PCDHGB3 protein network | https://string-db.org/network/9606.ENSP00000461862 | Protocadherin gamma-B3; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| MRPS21 protein network | https://string-db.org/network/9606.ENSP00000461930 | Mitochondrial ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family |
| RAB31 protein network | https://string-db.org/network/9606.ENSP00000461945 | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle bet [...] |
| PIRT protein network | https://string-db.org/network/9606.ENSP00000462046 | Phosphoinositide-interacting protein; Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol 4,5-bisph [...] |
| ZFP92 protein network | https://string-db.org/network/9606.ENSP00000462054 | Zinc finger protein 92 homolog; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RASSF5 protein network | https://string-db.org/network/9606.ENSP00000462099 | Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to i [...] |
| SMIM21 protein network | https://string-db.org/network/9606.ENSP00000462106 | Small integral membrane protein 21 |
| SAP30BP protein network | https://string-db.org/network/9606.ENSP00000462116 | SAP30-binding protein; Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival. May be involved in the regulation of beta-2-microglobulin genes; Belongs to [...] |
| BAHCC1 protein network | https://string-db.org/network/9606.ENSP00000462154 | BAH domain and coiled-coil containing 1 |
| ZNF488 protein network | https://string-db.org/network/9606.ENSP00000462269 | Zinc finger protein 488; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CD300LF protein network | https://string-db.org/network/9606.ENSP00000462309 | CMRF35-like molecule 1; Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recog [...] |
| ENGASE protein network | https://string-db.org/network/9606.ENSP00000462333 | Cytosolic endo-beta-N-acetylglucosaminidase; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in t [...] |
| VEZF1 protein network | https://string-db.org/network/9606.ENSP00000462337 | Vascular endothelial zinc finger 1; Possible transcription factor. Specifically binds to the CT/GC-rich region of the interleukin-3 promoter and mediates tax transactivation of IL-3; Zinc fingers [...] |
| STARD6 protein network | https://string-db.org/network/9606.ENSP00000462349 | StAR-related lipid transfer protein 6; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity); StAR related lipid transfe [...] |
| HIST2H4B protein network | https://string-db.org/network/9606.ENSP00000462355 | Histone cluster 2 H4 family member b; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| FAM222B protein network | https://string-db.org/network/9606.ENSP00000462419 | Protein FAM222B; Family with sequence similarity 222 member B |
| TPPP3 protein network | https://string-db.org/network/9606.ENSP00000462435 | Tubulin polymerization-promoting protein family member 3; Binds tubulin and has microtubule bundling activity. May play a role in cell proliferation and mitosis; Tubulin polymerization promoting [...] |
| YES1 protein network | https://string-db.org/network/9606.ENSP00000462468 | Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and diffe [...] |
| TXNIP protein network | https://string-db.org/network/9606.ENSP00000462521 | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced sup [...] |
| NBPF15 protein network | https://string-db.org/network/9606.ENSP00000462600 | Neuroblastoma breakpoint family member 15; NBPF member 15 |
| ADCYAP1 protein network | https://string-db.org/network/9606.ENSP00000462647 | Pituitary adenylate cyclase-activating polypeptide; Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development throug [...] |
| POLI protein network | https://string-db.org/network/9606.ENSP00000462664 | DNA polymerase iota; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot procee [...] |
| HIST2H4A protein network | https://string-db.org/network/9606.ENSP00000462667 | Histone cluster 2 H4 family member a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| CDH8 protein network | https://string-db.org/network/9606.ENSP00000462701 | Cadherin-8; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| CUEDC1 protein network | https://string-db.org/network/9606.ENSP00000462717 | CUE domain containing 1 |
| OTUD7B protein network | https://string-db.org/network/9606.ENSP00000462729 | OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acti [...] |
| DCAF8L2 protein network | https://string-db.org/network/9606.ENSP00000462745 | DDB1- and CUL4-associated factor 8-like protein 2; DDB1 and CUL4 associated factor 8 like 2; Belongs to the WD repeat DCAF8 family |
| TBC1D29 protein network | https://string-db.org/network/9606.ENSP00000462799 | TBC1 domain family member 29 |
| ENSG00000266202 protein network | https://string-db.org/network/9606.ENSP00000462879 | Uncharacterized protein; Belongs to the complex I LYR family |
| MSL1 protein network | https://string-db.org/network/9606.ENSP00000462945 | Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of [...] |
| TEFM protein network | https://string-db.org/network/9606.ENSP00000462963 | Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, inc [...] |
| SPATA33 protein network | https://string-db.org/network/9606.ENSP00000462996 | Spermatogenesis-associated protein 33; Spermatogenesis associated 33 |
| OAZ2 protein network | https://string-db.org/network/9606.ENSP00000463013 | Ornithine decarboxylase antizyme 2; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...] |
| NCOA4 protein network | https://string-db.org/network/9606.ENSP00000463027 | Nuclear receptor coactivator 4; Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor [...] |
| FAM72C protein network | https://string-db.org/network/9606.ENSP00000463032 | Protein FAM72C; Family with sequence similarity 72 member C; Belongs to the FAM72 family |
| GDF2 protein network | https://string-db.org/network/9606.ENSP00000463051 | Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells [...] |
| PPIAL4C protein network | https://string-db.org/network/9606.ENSP00000463057 | Peptidyl-prolyl cis-trans isomerase A-like 4C; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity [...] |
| RBM8A protein network | https://string-db.org/network/9606.ENSP00000463058 | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core [...] |
| RNF43 protein network | https://string-db.org/network/9606.ENSP00000463069 | E3 ubiquitin-protein ligase RNF43; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradati [...] |
| MARCH10 protein network | https://string-db.org/network/9606.ENSP00000463080 | Probable E3 ubiquitin-protein ligase MARCH10; E3 ubiquitin-protein ligase (Probable). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and [...] |
| MSMB protein network | https://string-db.org/network/9606.ENSP00000463092 | Beta-microseminoprotein; Microseminoprotein beta |
| RBP3 protein network | https://string-db.org/network/9606.ENSP00000463151 | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina |
| ANP32E protein network | https://string-db.org/network/9606.ENSP00000463154 | Acidic leucine-rich nuclear phosphoprotein 32 family member E; Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AF [...] |
| C19orf47 protein network | https://string-db.org/network/9606.ENSP00000463159 | Uncharacterized protein C19orf47; Chromosome 19 open reading frame 47 |
| TRIM16 protein network | https://string-db.org/network/9606.ENSP00000463188 | Tripartite motif-containing protein 16; May play a role in the regulation of keratinocyte differentiation; Tripartite motif containing |
| SNURF protein network | https://string-db.org/network/9606.ENSP00000463201 | SNRPN upstream reading frame |
| PABPC4L protein network | https://string-db.org/network/9606.ENSP00000463233 | Polyadenylate-binding protein 4-like; May bind RNA; RNA binding motif containing |
| TMEM98 protein network | https://string-db.org/network/9606.ENSP00000463245 | Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocat [...] |
| KLF14 protein network | https://string-db.org/network/9606.ENSP00000463287 | Kruppel like factor 14 |
| PTPRM protein network | https://string-db.org/network/9606.ENSP00000463325 | Receptor-type tyrosine-protein phosphatase mu; Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control; Fibronectin type III [...] |
| MIF4GD protein network | https://string-db.org/network/9606.ENSP00000463334 | MIF4G domain-containing protein; MIF4G domain containing |
| SMIM6 protein network | https://string-db.org/network/9606.ENSP00000463361 | Small integral membrane protein 6 |
| TMEM200C protein network | https://string-db.org/network/9606.ENSP00000463375 | Transmembrane protein 200C |
| RPL17-C18orf32 protein network | https://string-db.org/network/9606.ENSP00000463379 | RPL17-C18orf32 readthrough; Belongs to the universal ribosomal protein uL22 family |
| SEC22B protein network | https://string-db.org/network/9606.ENSP00000463393 | Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the [...] |
| PPIAL4F protein network | https://string-db.org/network/9606.ENSP00000463419 | Peptidylprolyl isomerase A like 4F |
| KCNH6 protein network | https://string-db.org/network/9606.ENSP00000463533 | Potassium voltage-gated channel subfamily H member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel pro [...] |
| MYL12B protein network | https://string-db.org/network/9606.ENSP00000463559 | Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phos [...] |
| ACP6 protein network | https://string-db.org/network/9606.ENSP00000463574 | Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysop [...] |
| RNF115 protein network | https://string-db.org/network/9606.ENSP00000463650 | E3 ubiquitin-protein ligase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biolog [...] |
| RBFOX3 protein network | https://string-db.org/network/9606.ENSP00000463653 | RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-med [...] |
| GJD3 protein network | https://string-db.org/network/9606.ENSP00000463752 | Gap junction delta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| CCDC79 protein network | https://string-db.org/network/9606.ENSP00000463762 | Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homolo [...] |
| KCNJ12 protein network | https://string-db.org/network/9606.ENSP00000463778 | ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling t [...] |
| RPL26 protein network | https://string-db.org/network/9606.ENSP00000463784 | Component of the large ribosomal subunit. |
| NBPF10 protein network | https://string-db.org/network/9606.ENSP00000463957 | Neuroblastoma breakpoint family member 10; NBPF member 10 |
| SLC16A3 protein network | https://string-db.org/network/9606.ENSP00000463978 | Monocarboxylate transporter 4; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-cha [...] |
| ENSG00000265118 protein network | https://string-db.org/network/9606.ENSP00000463981 | annotation not available |
| PITPNC1 protein network | https://string-db.org/network/9606.ENSP00000464006 | Cytoplasmic phosphatidylinositol transfer protein 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding [...] |
| IKBKE protein network | https://string-db.org/network/9606.ENSP00000464030 | Inhibitor of nuclear factor kappa-B kinase subunit epsilon; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of [...] |
| CDK11B protein network | https://string-db.org/network/9606.ENSP00000464036 | Cyclin-dependent kinase 11B; Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a [...] |
| KIAA0040 protein network | https://string-db.org/network/9606.ENSP00000464040 | Uncharacterized protein KIAA0040; KIAA0040 |
| DDX42 protein network | https://string-db.org/network/9606.ENSP00000464050 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence [...] |
| NOTCH2NL protein network | https://string-db.org/network/9606.ENSP00000464060 | Notch homolog 2 N-terminal-like protein; May function in the Notch signaling pathway and regulate neutrophil differentiation |
| RNF213 protein network | https://string-db.org/network/9606.ENSP00000464087 | E3 ubiquitin-protein ligase RNF213; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitina [...] |
| GDF10 protein network | https://string-db.org/network/9606.ENSP00000464145 | Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhi [...] |
| GREB1L protein network | https://string-db.org/network/9606.ENSP00000464162 | GREB1-like protein; Growth regulation by estrogen in breast cancer 1 like; Belongs to the GREB1 family |
| ENSG00000265303 protein network | https://string-db.org/network/9606.ENSP00000464167 | Uncharacterized protein |
| ZNF286A protein network | https://string-db.org/network/9606.ENSP00000464218 | Zinc finger protein 286A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| VHLL protein network | https://string-db.org/network/9606.ENSP00000464258 | Von Hippel-Lindau-like protein; Functions as a dominant-negative VHL to serve as a protector of HIFalpha |
| UBBP4 protein network | https://string-db.org/network/9606.ENSP00000464265 | Ubiquitin B pseudogene 4 |
| FAM25E protein network | https://string-db.org/network/9606.ENSP00000464272 | Protein FAM25E; Family with sequence similarity 25 member E; Belongs to the FAM25 family |
| C17orf75 protein network | https://string-db.org/network/9606.ENSP00000464275 | Protein Njmu-R1; May have a role in spermatogenesis |
| MYH3 protein network | https://string-db.org/network/9606.ENSP00000464317 | Myosin-3; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family |
| PTRH2 protein network | https://string-db.org/network/9606.ENSP00000464327 | Peptidyl-tRNA hydrolase 2, mitochondrial; The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family |
| C18orf63 protein network | https://string-db.org/network/9606.ENSP00000464330 | Uncharacterized protein C18orf63; Chromosome 18 open reading frame 63 |
| RPL36 protein network | https://string-db.org/network/9606.ENSP00000464342 | 60S ribosomal protein L36; Component of the large ribosomal subunit |
| ENSG00000263620 protein network | https://string-db.org/network/9606.ENSP00000464383 | Uncharacterized protein |
| C18orf32 protein network | https://string-db.org/network/9606.ENSP00000464411 | RPL17-C18orf32 readthrough; Chromosome 18 open reading frame 32; Belongs to the universal ribosomal protein uL22 family |
| IFT20 protein network | https://string-db.org/network/9606.ENSP00000464443 | Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins [...] |
| TIMM23 protein network | https://string-db.org/network/9606.ENSP00000464522 | Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across th [...] |
| LRRC37A3 protein network | https://string-db.org/network/9606.ENSP00000464535 | Leucine-rich repeat-containing protein 37A3; Leucine rich repeat containing 37 member A3 |
| PPIAL4H protein network | https://string-db.org/network/9606.ENSP00000464619 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) |
| FAM215A protein network | https://string-db.org/network/9606.ENSP00000464743 | Uncharacterized protein FAM215A; Family with sequence similarity 215 member A |
| TPGS2 protein network | https://string-db.org/network/9606.ENSP00000464780 | Tubulin polyglutamylase complex subunit 2 |
| ZNF285 protein network | https://string-db.org/network/9606.ENSP00000464788 | Zinc finger protein 285; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RPL27 protein network | https://string-db.org/network/9606.ENSP00000464813 | 60S ribosomal protein L27; Component of the large ribosomal subunit. Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs |
| COASY protein network | https://string-db.org/network/9606.ENSP00000464814 | Bifunctional coenzyme A synthase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine [...] |
| ZNF519 protein network | https://string-db.org/network/9606.ENSP00000464872 | Zinc finger protein 519; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| POU5F2 protein network | https://string-db.org/network/9606.ENSP00000464890 | POU domain, class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are requi [...] |
| UNK protein network | https://string-db.org/network/9606.ENSP00000464893 | RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during em [...] |
| MFSD11 protein network | https://string-db.org/network/9606.ENSP00000464932 | UNC93-like protein MFSD11; Major facilitator superfamily domain containing 11; Belongs to the unc-93 family |
| PLEKHJ1 protein network | https://string-db.org/network/9606.ENSP00000464955 | Pleckstrin homology domain containing J1 |
| ZNF850 protein network | https://string-db.org/network/9606.ENSP00000464976 | Zinc finger protein 850; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MAP4K1 protein network | https://string-db.org/network/9606.ENSP00000465039 | Mitogen-activated protein kinase kinase kinase kinase 1; Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-termi [...] |
| SPC24 protein network | https://string-db.org/network/9606.ENSP00000465075 | Kinetochore protein Spc24; Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for k [...] |
| CD3EAP protein network | https://string-db.org/network/9606.ENSP00000465099 | DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA p [...] |
| ZNF226 protein network | https://string-db.org/network/9606.ENSP00000465121 | Zinc finger protein 226; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CNTD1 protein network | https://string-db.org/network/9606.ENSP00000465204 | Cyclin N-terminal domain containing 1 |
| ENSG00000267360 protein network | https://string-db.org/network/9606.ENSP00000465212 | Uncharacterized protein; Zinc finger protein 585B |
| POP4 protein network | https://string-db.org/network/9606.ENSP00000465213 | Ribonuclease P protein subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. May function with RPP38 to coordinate the nucleolar t [...] |
| GCOM1 protein network | https://string-db.org/network/9606.ENSP00000465231 | GRINL1A combined protein 15; GRINL1A complex locus 1 |
| C19orf26 protein network | https://string-db.org/network/9606.ENSP00000465260 | Voltage-dependent calcium channel beta subunit-associated regulatory protein; Negatively regulates voltage-gated calcium channels by preventing the interaction between their alpha and beta subuni [...] |
| TMC6 protein network | https://string-db.org/network/9606.ENSP00000465261 | Transmembrane channel-like protein 6; Probable ion channel; Transmembrane channel likes |
| KCNJ16 protein network | https://string-db.org/network/9606.ENSP00000465295 | Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage de [...] |
| APOC1 protein network | https://string-db.org/network/9606.ENSP00000465356 | Apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with [...] |
| TJP3 protein network | https://string-db.org/network/9606.ENSP00000465419 | Tight junction protein ZO-3; Membrane associated guanylate kinases |
| C19orf53 protein network | https://string-db.org/network/9606.ENSP00000465432 | Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy |
| TNFRSF11A protein network | https://string-db.org/network/9606.ENSP00000465500 | Tumor necrosis factor receptor superfamily member 11A; Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between [...] |
| C18orf21 protein network | https://string-db.org/network/9606.ENSP00000465517 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 |
| ZNF529 protein network | https://string-db.org/network/9606.ENSP00000465578 | Zinc finger protein 529; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ACSBG2 protein network | https://string-db.org/network/9606.ENSP00000465589 | Long-chain-fatty-acid--CoA ligase ACSBG2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatt [...] |
| IER2 protein network | https://string-db.org/network/9606.ENSP00000465617 | Immediate early response gene 2 protein; DNA-binding protein that seems to act as a transcription factor. Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway a [...] |
| OVOL3 protein network | https://string-db.org/network/9606.ENSP00000465620 | Putative transcription factor ovo-like protein 3; May act as a transcription regulator |
| TMEM100 protein network | https://string-db.org/network/9606.ENSP00000465638 | Transmembrane protein 100; Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation b [...] |
| PIAS2 protein network | https://string-db.org/network/9606.ENSP00000465676 | E3 SUMO-protein ligase PIAS2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Pla [...] |
| SLC16A2 protein network | https://string-db.org/network/9606.ENSP00000465734 | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidot [...] |
| CCDC106 protein network | https://string-db.org/network/9606.ENSP00000465757 | Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity |
| POLRMT protein network | https://string-db.org/network/9606.ENSP00000465759 | DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates |
| CCDC130 protein network | https://string-db.org/network/9606.ENSP00000465776 | Coiled-coil domain containing 130; Belongs to the CWC16 family |
| MPPE1 protein network | https://string-db.org/network/9606.ENSP00000465894 | Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturatio [...] |
| GALK1 protein network | https://string-db.org/network/9606.ENSP00000465930 | Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily |
| PRCD protein network | https://string-db.org/network/9606.ENSP00000465932 | Progressive rod-cone degeneration protein; Involved in vision |
| KIF18B protein network | https://string-db.org/network/9606.ENSP00000465992 | Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 alo [...] |
| PPY protein network | https://string-db.org/network/9606.ENSP00000466009 | Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Endogenous ligands |
| ZNF581 protein network | https://string-db.org/network/9606.ENSP00000466047 | Zinc finger protein 581; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF404 protein network | https://string-db.org/network/9606.ENSP00000466051 | Zinc finger protein 404; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RDH8 protein network | https://string-db.org/network/9606.ENSP00000466058 | Retinol dehydrogenase 8; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high lig [...] |
| LYPD8 protein network | https://string-db.org/network/9606.ENSP00000466070 | Ly6/PLAUR domain-containing protein 8; Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the larg [...] |
| ZSCAN5B protein network | https://string-db.org/network/9606.ENSP00000466072 | Zinc finger and SCAN domain-containing protein 5B; May be involved in transcriptional regulation; SCAN domain containing |
| ELANE protein network | https://string-db.org/network/9606.ENSP00000466090 | Neutrophil elastase; Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis |
| C19orf40 protein network | https://string-db.org/network/9606.ENSP00000466121 | Fanconi anemia core complex-associated protein 24; Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induc [...] |
| PRKCSH protein network | https://string-db.org/network/9606.ENSP00000466134 | Glucosidase 2 subunit beta; Regulatory subunit of glucosidase II; EF-hand domain containing |
| ATF7-NPFF protein network | https://string-db.org/network/9606.ENSP00000466174 | Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. |
| PDCD5 protein network | https://string-db.org/network/9606.ENSP00000466214 | Programmed cell death protein 5; May function in the process of apoptosis |
| PLK5 protein network | https://string-db.org/network/9606.ENSP00000466248 | Inactive serine/threonine-protein kinase PLK5; Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation; Belongs to the protein kinase sup [...] |
| ZNF540 protein network | https://string-db.org/network/9606.ENSP00000466274 | Zinc finger protein 540; May act as a transcriptional repressor; Zinc fingers C2H2-type |
| NLRP11 protein network | https://string-db.org/network/9606.ENSP00000466285 | NACHT, LRR and PYD domains-containing protein 11; Involved in inflammation; NLR family |
| STX10 protein network | https://string-db.org/network/9606.ENSP00000466298 | Syntaxin-10; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family |
| PIP5K1C protein network | https://string-db.org/network/9606.ENSP00000466363 | Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) [...] |
| ASNA1 protein network | https://string-db.org/network/9606.ENSP00000466379 | ATPase ASNA1; ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA prot [...] |
| RAD51D protein network | https://string-db.org/network/9606.ENSP00000466399 | Uncharacterized protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to sing [...] |
| TSSK6 protein network | https://string-db.org/network/9606.ENSP00000466477 | Testis-specific serine/threonine-protein kinase 6; Required for sperm production and function. Plays a role in DNA condensation during postmeiotic chromatin remodeling (By similarity) |
| ENSG00000267157 protein network | https://string-db.org/network/9606.ENSP00000466514 | Uncharacterized protein |
| TLE2 protein network | https://string-db.org/network/9606.ENSP00000466542 | Transducin-like enhancer protein 2; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members [...] |
| CEACAM16 protein network | https://string-db.org/network/9606.ENSP00000466561 | Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin s [...] |
| ENSG00000267740 protein network | https://string-db.org/network/9606.ENSP00000466639 | Uncharacterized protein |
| RND2 protein network | https://string-db.org/network/9606.ENSP00000466680 | Rho-related GTP-binding protein RhoN; May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity) |
| CCDC68 protein network | https://string-db.org/network/9606.ENSP00000466690 | Coiled-coil domain-containing protein 68; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC120, cooperate wi [...] |
| ZNF266 protein network | https://string-db.org/network/9606.ENSP00000466714 | Zinc finger protein 266; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| LSM12 protein network | https://string-db.org/network/9606.ENSP00000466718 | LSM12 homolog |
| APOC2 protein network | https://string-db.org/network/9606.ENSP00000466775 | Apolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lip [...] |
| HSD17B1 protein network | https://string-db.org/network/9606.ENSP00000466799 | Estradiol 17-beta-dehydrogenase 1; Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH; Short chain dehydrogenase/reductase superfamily |
| ENSG00000267168 protein network | https://string-db.org/network/9606.ENSP00000466829 | Uncharacterized protein |
| ENSG00000267618 protein network | https://string-db.org/network/9606.ENSP00000466834 | annotation not available |
| FUT5 protein network | https://string-db.org/network/9606.ENSP00000466880 | Alpha-(1,3)-fucosyltransferase 5; May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens; Fucosyltransferases |
| CIRBP protein network | https://string-db.org/network/9606.ENSP00000466897 | Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival [...] |
| LPPR2 protein network | https://string-db.org/network/9606.ENSP00000466898 | Lipid phosphate phosphatase-related protein type 2 |
| ZNF524 protein network | https://string-db.org/network/9606.ENSP00000466907 | Zinc finger protein 524; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| S1PR2 protein network | https://string-db.org/network/9606.ENSP00000466933 | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types o [...] |
| FHOD3 protein network | https://string-db.org/network/9606.ENSP00000466937 | FH1/FH2 domain-containing protein 3; Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament poly [...] |
| WTIP protein network | https://string-db.org/network/9606.ENSP00000466953 | Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell [...] |
| TRMT1 protein network | https://string-db.org/network/9606.ENSP00000466967 | tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I [...] |
| TMUB2 protein network | https://string-db.org/network/9606.ENSP00000466971 | Transmembrane and ubiquitin like domain containing 2 |
| LRFN3 protein network | https://string-db.org/network/9606.ENSP00000466989 | Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Cell adhesion molecule that mediates homophilic cell- cell adhesion in a Ca(2+)-independent manner. Promotes neurite outg [...] |
| RAD23A protein network | https://string-db.org/network/9606.ENSP00000467024 | UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent ma [...] |
| ENSG00000267140 protein network | https://string-db.org/network/9606.ENSP00000467041 | Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair |
| MUM1 protein network | https://string-db.org/network/9606.ENSP00000467083 | PWWP domain-containing protein MUM1; Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 a [...] |
| RINL protein network | https://string-db.org/network/9606.ENSP00000467107 | Ras and Rab interactor-like protein; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosi [...] |
| NLRP7 protein network | https://string-db.org/network/9606.ENSP00000467123 | NACHT, LRR and PYD domains-containing protein 7; Inhibits CASP1/caspase-1-dependent IL1B secretion; Belongs to the NLRP family |
| TTN protein network | https://string-db.org/network/9606.ENSP00000467141 | Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forc [...] |
| TNNT1 protein network | https://string-db.org/network/9606.ENSP00000467176 | Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin A [...] |
| ZNF570 protein network | https://string-db.org/network/9606.ENSP00000467218 | Zinc finger protein 570; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| UQCR11 protein network | https://string-db.org/network/9606.ENSP00000467262 | Cytochrome b-c1 complex subunit 10; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory ch [...] |
| COX6B2 protein network | https://string-db.org/network/9606.ENSP00000467266 | Cytochrome c oxidase subunit 6B2; Connects the two COX monomers into the physiological dimeric form; Belongs to the cytochrome c oxidase subunit 6B family |
| ABCA8 protein network | https://string-db.org/network/9606.ENSP00000467271 | ATP-binding cassette sub-family A member 8; ATP-dependent lipophilic drug transporter; ATP binding cassette subfamily A |
| ENSG00000267179 protein network | https://string-db.org/network/9606.ENSP00000467286 | Zinc finger protein 763; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SEMA6B protein network | https://string-db.org/network/9606.ENSP00000467290 | Semaphorin-6B; May play a role in both peripheral and central nervous system development; Semaphorins |
| OR4F17 protein network | https://string-db.org/network/9606.ENSP00000467301 | Olfactory receptor 4F17; Odorant receptor; Olfactory receptors, family 4 |
| SAFB protein network | https://string-db.org/network/9606.ENSP00000467423 | Scaffold attachment factor B1; Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR [...] |
| RPS15 protein network | https://string-db.org/network/9606.ENSP00000467466 | Ribosomal protein S15 |
| GIPR protein network | https://string-db.org/network/9606.ENSP00000467494 | Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled rece [...] |
| GPATCH8 protein network | https://string-db.org/network/9606.ENSP00000467556 | G-patch domain containing 8 |
| WBP2 protein network | https://string-db.org/network/9606.ENSP00000467579 | WW domain-binding protein 2; Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1- responsive [...] |
| ZNF699 protein network | https://string-db.org/network/9606.ENSP00000467723 | Zinc finger protein 699; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ANKRD62 protein network | https://string-db.org/network/9606.ENSP00000467740 | Ankyrin repeat domain-containing protein 62; Ankyrin repeat domain containing |
| LINGO3 protein network | https://string-db.org/network/9606.ENSP00000467753 | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3; Leucine rich repeat and Ig domain containing 3 |
| BOD1L2 protein network | https://string-db.org/network/9606.ENSP00000467843 | Biorientation of chromosomes in cell division protein 1-like 2; May play a role in proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles |
| ZNF461 protein network | https://string-db.org/network/9606.ENSP00000467931 | Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ENSG00000267001 protein network | https://string-db.org/network/9606.ENSP00000467958 | Uncharacterized protein |
| KANK2 protein network | https://string-db.org/network/9606.ENSP00000468002 | KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the [...] |
| LUZP6 protein network | https://string-db.org/network/9606.ENSP00000468007 | Leucine zipper protein 6 |
| TMEM101 protein network | https://string-db.org/network/9606.ENSP00000468025 | Transmembrane protein 101; May activate NF-kappa-B signaling pathways |
| SARM1 protein network | https://string-db.org/network/9606.ENSP00000468032 | Sterile alpha and TIR motif-containing protein 1; Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneratio [...] |
| ENSG00000267748 protein network | https://string-db.org/network/9606.ENSP00000468040 | annotation not available |
| ZNF101 protein network | https://string-db.org/network/9606.ENSP00000468049 | Zinc finger protein 101; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HSPB6 protein network | https://string-db.org/network/9606.ENSP00000468057 | Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functio [...] |
| ZNF559 protein network | https://string-db.org/network/9606.ENSP00000468153 | Zinc finger protein 559; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| CCDC159 protein network | https://string-db.org/network/9606.ENSP00000468232 | Coiled-coil domain containing 159 |
| APOC4 protein network | https://string-db.org/network/9606.ENSP00000468236 | Apolipoprotein C-IV; May participate in lipoprotein metabolism; Apolipoproteins |
| ERC1 protein network | https://string-db.org/network/9606.ENSP00000468263 | ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at t [...] |
| ENSG00000267173 protein network | https://string-db.org/network/9606.ENSP00000468271 | Uncharacterized protein |
| ENSG00000267318 protein network | https://string-db.org/network/9606.ENSP00000468280 | Uncharacterized protein |
| MBTD1 protein network | https://string-db.org/network/9606.ENSP00000468304 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering [...] |
| FAM20A protein network | https://string-db.org/network/9606.ENSP00000468308 | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM2 [...] |
| EML2 protein network | https://string-db.org/network/9606.ENSP00000468312 | Echinoderm microtubule-associated protein-like 2; Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules; WD repeat domain containing |
| MAP2K6 protein network | https://string-db.org/network/9606.ENSP00000468348 | Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, c [...] |
| ANKRD29 protein network | https://string-db.org/network/9606.ENSP00000468354 | Ankyrin repeat domain-containing protein 29; Ankyrin repeat domain containing |
| ENSG00000267261 protein network | https://string-db.org/network/9606.ENSP00000468367 | Uncharacterized protein |
| PSENEN protein network | https://string-db.org/network/9606.ENSP00000468411 | Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch rece [...] |
| NMT1 protein network | https://string-db.org/network/9606.ENSP00000468424 | Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins |
| GFAP protein network | https://string-db.org/network/9606.ENSP00000468500 | Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from othe [...] |
| ZNF177 protein network | https://string-db.org/network/9606.ENSP00000468531 | Zinc finger protein 177; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SEC11C protein network | https://string-db.org/network/9606.ENSP00000468633 | Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen [...] |
| PLEKHH3 protein network | https://string-db.org/network/9606.ENSP00000468678 | Pleckstrin homology, MyTH4 and FERM domain containing H3 |
| ENSG00000266953 protein network | https://string-db.org/network/9606.ENSP00000468690 | Uncharacterized protein |
| ZNF253 protein network | https://string-db.org/network/9606.ENSP00000468720 | Zinc finger protein 253; May function as a transcription factor. Seem to have a transcriptional repression activity; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ACP5 protein network | https://string-db.org/network/9606.ENSP00000468767 | Tartrate-resistant acid phosphatase type 5; Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgki [...] |
| ZBTB7C protein network | https://string-db.org/network/9606.ENSP00000468782 | Zinc finger and BTB domain-containing protein 7C; May be a tumor suppressor gene; BTB domain containing |
| MBD1 protein network | https://string-db.org/network/9606.ENSP00000468785 | Methyl-CpG-binding domain protein 1; Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is aboli [...] |
| ENSG00000268434 protein network | https://string-db.org/network/9606.ENSP00000468837 | Uncharacterized protein |
| FPR2 protein network | https://string-db.org/network/9606.ENSP00000468897 | N-formyl peptide receptor 2; Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutro [...] |
| STAP2 protein network | https://string-db.org/network/9606.ENSP00000468927 | Signal transducing adaptor family member 2 |
| JOSD2 protein network | https://string-db.org/network/9606.ENSP00000468956 | Josephin-2; Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme; MJD deubiquinating en [...] |
| WDR83OS protein network | https://string-db.org/network/9606.ENSP00000468969 | Protein Asterix; WD repeat domain 83 opposite strand |
| SLC25A53 protein network | https://string-db.org/network/9606.ENSP00000468980 | Solute carrier family 25 member 53 |
| ZIM2 protein network | https://string-db.org/network/9606.ENSP00000468984 | Zinc finger imprinted 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| MTRNR2L12 protein network | https://string-db.org/network/9606.ENSP00000468991 | annotation not available |
| SSX4 protein network | https://string-db.org/network/9606.ENSP00000469011 | Synovial sarcoma, X breakpoint 4; Could act as a modulator of transcription |
| ZNF574 protein network | https://string-db.org/network/9606.ENSP00000469029 | Zinc finger protein 574; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TNFSF14 protein network | https://string-db.org/network/9606.ENSP00000469049 | Tumor necrosis factor ligand superfamily member 14; Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation [...] |
| ZBTB45 protein network | https://string-db.org/network/9606.ENSP00000469089 | Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (By simila [...] |
| NPAS1 protein network | https://string-db.org/network/9606.ENSP00000469142 | Neuronal PAS domain-containing protein 1; May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulat [...] |
| SLITRK4 protein network | https://string-db.org/network/9606.ENSP00000469205 | SLIT and NTRK-like protein 4; It is involved in synaptogenesis and promotes synapse differentiation. Suppresses neurite outgrowth (By similarity); Belongs to the SLITRK family |
| HSFX2 protein network | https://string-db.org/network/9606.ENSP00000469223 | Heat shock transcription factor family, X-linked 2 |
| CHMP2A protein network | https://string-db.org/network/9606.ENSP00000469240 | Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation [...] |
| FAM156B protein network | https://string-db.org/network/9606.ENSP00000469248 | Family with sequence similarity 156 member B |
| KLK15 protein network | https://string-db.org/network/9606.ENSP00000469315 | Kallikrein-15; Protease whose physiological substrate is not yet known; Kallikreins |
| GABRQ protein network | https://string-db.org/network/9606.ENSP00000469332 | Gamma-aminobutyric acid receptor subunit theta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...] |
| LRRC63 protein network | https://string-db.org/network/9606.ENSP00000469337 | Leucine-rich repeat-containing protein 63; Leucine rich repeat containing 63 |
| ZNF677 protein network | https://string-db.org/network/9606.ENSP00000469391 | Zinc finger protein 677; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| SSX4B protein network | https://string-db.org/network/9606.ENSP00000469394 | Protein SSX4; Could act as a modulator of transcription |
| PAK4 protein network | https://string-db.org/network/9606.ENSP00000469413 | Serine/threonine-protein kinase PAK 4; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, pr [...] |
| KLK9 protein network | https://string-db.org/network/9606.ENSP00000469417 | Kallikrein-9; Kallikrein related peptidase 9; Kallikreins |
| ENSG00000267881 protein network | https://string-db.org/network/9606.ENSP00000469421 | Carcinoembryonic antigen-related cell adhesion molecule 5 isoform 3D |
| CTAG1A protein network | https://string-db.org/network/9606.ENSP00000469441 | Cancer/testis antigen 1A; Belongs to the CTAG/PCC1 family |
| PNMA3 protein network | https://string-db.org/network/9606.ENSP00000469445 | Paraneoplastic Ma antigens; Belongs to the PNMA family |
| NTF4 protein network | https://string-db.org/network/9606.ENSP00000469455 | Neurotrophin-4; Target-derived survival factor for peripheral sensory sympathetic neurons; Neurotrophins |
| LSM4 protein network | https://string-db.org/network/9606.ENSP00000469468 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA; Belongs to the snRNP Sm proteins family |
| CCDC177 protein network | https://string-db.org/network/9606.ENSP00000469474 | Coiled-coil domain containing 177 |
| ZNF729 protein network | https://string-db.org/network/9606.ENSP00000469582 | Zinc finger protein 729; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF628 protein network | https://string-db.org/network/9606.ENSP00000469591 | Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity); Zinc fingers C2H2-type |
| FLT3LG protein network | https://string-db.org/network/9606.ENSP00000469613 | Fms-related tyrosine kinase 3 ligand; Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleuk [...] |
| ZFP36 protein network | https://string-db.org/network/9606.ENSP00000469647 | mRNA decay activator protein ZFP36; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal [...] |
| EGLN2 protein network | https://string-db.org/network/9606.ENSP00000469686 | Egl nine homolog 2; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydrox [...] |
| SHANK2 protein network | https://string-db.org/network/9606.ENSP00000469689 | SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membran [...] |
| ENSG00000268187 protein network | https://string-db.org/network/9606.ENSP00000469705 | annotation not available |
| LRIT3 protein network | https://string-db.org/network/9606.ENSP00000469759 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3; Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite [...] |
| MPV17L2 protein network | https://string-db.org/network/9606.ENSP00000469836 | Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome. Is a positive regulator of mitochondrial protein synthesis; Belongs to the peroxisomal membrane protei [...] |
| DYRK1B protein network | https://string-db.org/network/9606.ENSP00000469863 | Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity [...] |
| SCGB2B2 protein network | https://string-db.org/network/9606.ENSP00000469876 | Secretoglobin family 2B member 2; Secretoglobins |
| VRK3 protein network | https://string-db.org/network/9606.ENSP00000469880 | Inactive serine/threonine-protein kinase VRK3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in t [...] |
| TRAPPC2P1 protein network | https://string-db.org/network/9606.ENSP00000469888 | Trafficking protein particle complex 2 pseudogene 1 |
| ZNF626 protein network | https://string-db.org/network/9606.ENSP00000469958 | Zinc finger protein 626; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ENSG00000268221 protein network | https://string-db.org/network/9606.ENSP00000469970 | Opsin 1 (cone pigments), medium-wave-sensitive; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal |
| TAZ protein network | https://string-db.org/network/9606.ENSP00000469981 | Tafazzin; Some isoforms may be involved in cardiolipin (CL) metabolism; Belongs to the taffazin family |
| ZNF114 protein network | https://string-db.org/network/9606.ENSP00000469998 | Zinc finger protein 114; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| NOSIP protein network | https://string-db.org/network/9606.ENSP00000470034 | Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/thr [...] |
| ENSG00000268083 protein network | https://string-db.org/network/9606.ENSP00000470059 | Uncharacterized protein; Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial |
| DEDD2 protein network | https://string-db.org/network/9606.ENSP00000470082 | DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of in [...] |
| ENSG00000268643 protein network | https://string-db.org/network/9606.ENSP00000470087 | Uncharacterized protein; Belongs to the protein kinase superfamily |
| ZSCAN18 protein network | https://string-db.org/network/9606.ENSP00000470123 | Zinc finger and SCAN domain-containing protein 18; May be involved in transcriptional regulation; SCAN domain containing |
| UPF1 protein network | https://string-db.org/network/9606.ENSP00000470142 | Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translatio [...] |
| DTNA protein network | https://string-db.org/network/9606.ENSP00000470152 | Dystrobrevin alpha; May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors; Belongs to the dystrophin family. [...] |
| CT45A1 protein network | https://string-db.org/network/9606.ENSP00000470185 | Cancer/testis antigen family 45 member A1; Belongs to the CT45 family |
| ZNF257 protein network | https://string-db.org/network/9606.ENSP00000470209 | Zinc finger protein 257; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF836 protein network | https://string-db.org/network/9606.ENSP00000470239 | Zinc finger protein 836; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| PRICKLE3 protein network | https://string-db.org/network/9606.ENSP00000470248 | Prickle planar cell polarity protein 3; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gas [...] |
| SUPT5H protein network | https://string-db.org/network/9606.ENSP00000470252 | Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. D [...] |
| ENSG00000268500 protein network | https://string-db.org/network/9606.ENSP00000470259 | Sialic acid-binding Ig-like lectin 5; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sial [...] |
| TRAPPC5 protein network | https://string-db.org/network/9606.ENSP00000470262 | Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily |
| MYH14 protein network | https://string-db.org/network/9606.ENSP00000470298 | Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Deafness associated genes |
| ZNF329 protein network | https://string-db.org/network/9606.ENSP00000470323 | Zinc finger protein 329; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF468 protein network | https://string-db.org/network/9606.ENSP00000470381 | Zinc finger protein 468; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ENSG00000268465 protein network | https://string-db.org/network/9606.ENSP00000470383 | Cytohesin-2 |
| ENSG00000268714 protein network | https://string-db.org/network/9606.ENSP00000470389 | annotation not available |
| LOC646862 protein network | https://string-db.org/network/9606.ENSP00000470441 | RING finger protein 225; Uncharacterized protein LOC646862 |
| LOC388210 protein network | https://string-db.org/network/9606.ENSP00000470478 | Putative uncharacterized protein LOC400499; Protein LOC101929274 |
| ZNF432 protein network | https://string-db.org/network/9606.ENSP00000470488 | Zinc finger protein 432; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FBN3 protein network | https://string-db.org/network/9606.ENSP00000470498 | Fibrillin-3; Fibrillin-3: Fibrillins are structural components of 10- 12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. [...] |
| PET100 protein network | https://string-db.org/network/9606.ENSP00000470539 | Protein PET100 homolog, mitochondrial; PET100 homolog; Belongs to the PET100 family |
| KLK13 protein network | https://string-db.org/network/9606.ENSP00000470555 | Kallikrein-13; Kallikrein related peptidase 13; Kallikreins |
| EMG1 protein network | https://string-db.org/network/9606.ENSP00000470560 | Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. I [...] |
| SPANXN2 protein network | https://string-db.org/network/9606.ENSP00000470584 | Sperm protein associated with the nucleus on the X chromosome N2; SPANX family member N2 |
| SLC35E1 protein network | https://string-db.org/network/9606.ENSP00000470652 | Solute carrier family 35 member E1; Putative transporter; Solute carriers |
| ZSCAN5DP protein network | https://string-db.org/network/9606.ENSP00000470691 | Zinc finger and SCAN domain containing 5D pseudogene |
| ZNF841 protein network | https://string-db.org/network/9606.ENSP00000470746 | Zinc finger protein 841; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| IL12RB1 protein network | https://string-db.org/network/9606.ENSP00000470788 | Interleukin-12 receptor subunit beta-1; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a [...] |
| SLC6A14 protein network | https://string-db.org/network/9606.ENSP00000470801 | Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+); Mediates the uptake of a broad range of neutral and cationic amino acids (with the exception of proline) in a Na(+)/ [...] |
| CGB7 protein network | https://string-db.org/network/9606.ENSP00000470813 | Choriogonadotropin subunit beta 7; Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalen [...] |
| TMEM59L protein network | https://string-db.org/network/9606.ENSP00000470879 | Transmembrane protein 59-like; Modulates the O-glycosylation and complex N- glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and furthe [...] |
| FAM231C protein network | https://string-db.org/network/9606.ENSP00000470910 | Protein FAM231B; Family with sequence similarity 231 member C; Belongs to the FAM231 family |
| RPS19 protein network | https://string-db.org/network/9606.ENSP00000470972 | 40S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family |
| ZNF616 protein network | https://string-db.org/network/9606.ENSP00000471000 | Zinc finger protein 616; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MAGEA9 protein network | https://string-db.org/network/9606.ENSP00000471017 | Melanoma-associated antigen 9; Not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family |
| SMIM17 protein network | https://string-db.org/network/9606.ENSP00000471126 | Small integral membrane protein 17 |
| NUP62 protein network | https://string-db.org/network/9606.ENSP00000471191 | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein i [...] |
| DMRTC1 protein network | https://string-db.org/network/9606.ENSP00000471224 | Doublesex- and mab-3-related transcription factor C1; DMRT like family C1; Belongs to the DMRT family |
| FARP1 protein network | https://string-db.org/network/9606.ENSP00000471242 | FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disass [...] |
| ANKRD24 protein network | https://string-db.org/network/9606.ENSP00000471252 | Ankyrin repeat domain-containing protein 24; Ankyrin repeat domain containing |
| FAM71E1 protein network | https://string-db.org/network/9606.ENSP00000471272 | Protein FAM71E1; Family with sequence similarity 71 member E1 |
| ZNF558 protein network | https://string-db.org/network/9606.ENSP00000471277 | Zinc finger protein 558; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| MAGIX protein network | https://string-db.org/network/9606.ENSP00000471299 | PDZ domain-containing protein MAGIX; MAGI family member, X-linked; PDZ domain containing |
| FAM234A protein network | https://string-db.org/network/9606.ENSP00000471331 | cDNA FLJ60496; Protein ITFG3; Uncharacterized protein; cDNA FLJ60496 |
| ANKDD1B protein network | https://string-db.org/network/9606.ENSP00000471417 | Ankyrin repeat and death domain containing 1B |
| CT45A3 protein network | https://string-db.org/network/9606.ENSP00000471418 | Cancer/testis antigen family 45 member A3; Belongs to the CT45 family |
| CCDC61 protein network | https://string-db.org/network/9606.ENSP00000471454 | Coiled-coil domain containing 61 |
| CCDC124 protein network | https://string-db.org/network/9606.ENSP00000471455 | Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages; Belongs to the CCDC124 family |
| MYO9B protein network | https://string-db.org/network/9606.ENSP00000471457 | Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absenc [...] |
| C19orf48 protein network | https://string-db.org/network/9606.ENSP00000471463 | Uncharacterized protein C19orf48; Chromosome 19 open reading frame 48; Minor histocompatibility antigens |
| FGF21 protein network | https://string-db.org/network/9606.ENSP00000471477 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity re [...] |
| FPR1 protein network | https://string-db.org/network/9606.ENSP00000471493 | fMet-Leu-Phe receptor; High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular c [...] |
| LRRC4B protein network | https://string-db.org/network/9606.ENSP00000471502 | Leucine-rich repeat-containing protein 4B; Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation [...] |
| ZNF726 protein network | https://string-db.org/network/9606.ENSP00000471516 | Zinc finger protein 726; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MARCH2 protein network | https://string-db.org/network/9606.ENSP00000471536 | E3 ubiquitin-protein ligase MARCH2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicu [...] |
| ZNF615 protein network | https://string-db.org/network/9606.ENSP00000471549 | Zinc finger protein 615; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MBD3L1 protein network | https://string-db.org/network/9606.ENSP00000471575 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor |
| ZNF728 protein network | https://string-db.org/network/9606.ENSP00000471593 | Zinc finger protein 728; Zinc fingers C2H2-type |
| TEX13A protein network | https://string-db.org/network/9606.ENSP00000471604 | Testis-expressed protein 13A; Zinc fingers RANBP2-type ; Belongs to the TEX13 family |
| ENSG00000268861 protein network | https://string-db.org/network/9606.ENSP00000471635 | Uncharacterized protein; Rho guanine nucleotide exchange factor 18 |
| SCGB1C2 protein network | https://string-db.org/network/9606.ENSP00000471646 | Secretoglobin, family 1C, member 1-like precursor |
| SLC38A5 protein network | https://string-db.org/network/9606.ENSP00000471683 | Sodium-coupled neutral amino acid transporter 5; Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH- sensitive, and electrogenic cot [...] |
| PPP5D1 protein network | https://string-db.org/network/9606.ENSP00000471730 | Protein PPP5D1; PPP5 tetratricopeptide repeat domain containing 1 |
| MPND protein network | https://string-db.org/network/9606.ENSP00000471735 | Probable protease (By similarity). Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation . |
| ZNF480 protein network | https://string-db.org/network/9606.ENSP00000471754 | Zinc finger protein 480; Involved in transcriptional regulation as an activator; Zinc fingers C2H2-type |
| HAMP protein network | https://string-db.org/network/9606.ENSP00000471894 | Hepcidin; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, [...] |
| IRF3 protein network | https://string-db.org/network/9606.ENSP00000471896 | Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA v [...] |
| ZNF17 protein network | https://string-db.org/network/9606.ENSP00000471905 | Zinc finger protein 17; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| SPIB protein network | https://string-db.org/network/9606.ENSP00000471921 | Transcription factor Spi-B; Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes [...] |
| TMEM185A protein network | https://string-db.org/network/9606.ENSP00000471932 | Transmembrane protein 185A; Belongs to the TMEM185 family |
| C5orf58 protein network | https://string-db.org/network/9606.ENSP00000471984 | Putative uncharacterized protein C5orf58; Chromosome 5 open reading frame 58 |
| TEAD2 protein network | https://string-db.org/network/9606.ENSP00000472109 | Transcriptional enhancer factor TEF-4; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting pr [...] |
| MAGED4 protein network | https://string-db.org/network/9606.ENSP00000472118 | Melanoma-associated antigen D4; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of [...] |
| GMFG protein network | https://string-db.org/network/9606.ENSP00000472249 | Glia maturation factor gamma |
| SUGP2 protein network | https://string-db.org/network/9606.ENSP00000472286 | SURP and G-patch domain-containing protein 2; May play a role in mRNA splicing; G-patch domain containing |
| ZNF358 protein network | https://string-db.org/network/9606.ENSP00000472305 | Zinc finger protein 358; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| TEX101 protein network | https://string-db.org/network/9606.ENSP00000472308 | Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct (By similarity). May play a role in sig [...] |
| ENSG00000268221 protein network | https://string-db.org/network/9606.ENSP00000472316 | annotation not available |
| ARL14EPL protein network | https://string-db.org/network/9606.ENSP00000472409 | ARL14 effector protein-like; ADP ribosylation factor like GTPase 14 effector protein like |
| ENSG00000269035 protein network | https://string-db.org/network/9606.ENSP00000472415 | Uncharacterized protein |
| ENSG00000269547 protein network | https://string-db.org/network/9606.ENSP00000472465 | Uncharacterized protein; Serine--tRNA ligase, mitochondrial |
| CXCL17 protein network | https://string-db.org/network/9606.ENSP00000472467 | C-X-C motif chemokine 17; Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. Plays a role in angiogenesis and possibly in the development of tumors. Acts as an [...] |
| RPS28 protein network | https://string-db.org/network/9606.ENSP00000472469 | Ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family |
| IL4I1 protein network | https://string-db.org/network/9606.ENSP00000472474 | L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation (By similarity); Belongs t [...] |
| PLA2G4C protein network | https://string-db.org/network/9606.ENSP00000472546 | Cytosolic phospholipase A2 gamma; Has a preference for arachidonic acid at the sn-2 position of phosphatidylcholine as compared with palmitic acid; Phospholipases |
| ZNF83 protein network | https://string-db.org/network/9606.ENSP00000472619 | Zinc finger protein 83; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| C5AR2 protein network | https://string-db.org/network/9606.ENSP00000472620 | C5a anaphylatoxin chemotactic receptor 2; Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C [...] |
| ASCL5 protein network | https://string-db.org/network/9606.ENSP00000472681 | Achaete-scute homolog 5; Achaete-scute family bHLH transcription factor 5; Basic helix-loop-helix proteins |
| ENSG00000268361 protein network | https://string-db.org/network/9606.ENSP00000472698 | annotation not available |
| ENSG00000269590 protein network | https://string-db.org/network/9606.ENSP00000472710 | Uncharacterized protein |
| ENSG00000158164 protein network | https://string-db.org/network/9606.ENSP00000472749 | Thymosin beta-15A; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); B [...] |
| ZNF446 protein network | https://string-db.org/network/9606.ENSP00000472802 | Zinc finger protein 446; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ZNF473 protein network | https://string-db.org/network/9606.ENSP00000472808 | Zinc finger protein 473; Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but h [...] |
| KXD1 protein network | https://string-db.org/network/9606.ENSP00000472836 | KxDL motif-containing protein 1; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BOR [...] |
| SARS2 protein network | https://string-db.org/network/9606.ENSP00000472847 | Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), w [...] |
| ZIK1 protein network | https://string-db.org/network/9606.ENSP00000472867 | Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor; Zinc fingers C2H2-type |
| ENSG00000268133 protein network | https://string-db.org/network/9606.ENSP00000472894 | Uncharacterized protein |
| ERVV-2 protein network | https://string-db.org/network/9606.ENSP00000472919 | Endogenous retrovirus group V member 2, envelope; Belongs to the gamma type-C retroviral envelope protein family |
| VAV1 protein network | https://string-db.org/network/9606.ENSP00000472929 | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation; Pleckstrin homology domain containing |
| ZNF730 protein network | https://string-db.org/network/9606.ENSP00000472959 | Putative zinc finger protein 730; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZNF99 protein network | https://string-db.org/network/9606.ENSP00000472969 | Zinc finger protein 99; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| RPS5 protein network | https://string-db.org/network/9606.ENSP00000472985 | Ribosomal protein S5; Belongs to the universal ribosomal protein uS7 family |
| SNRNP70 protein network | https://string-db.org/network/9606.ENSP00000472998 | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome [...] |
| FCHO1 protein network | https://string-db.org/network/9606.ENSP00000473001 | F-BAR domain only protein 1; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formati [...] |
| PNMAL2 protein network | https://string-db.org/network/9606.ENSP00000473036 | Paraneoplastic antigen-like protein 8B; Paraneoplastic Ma antigen family-like 2 |
| KLK11 protein network | https://string-db.org/network/9606.ENSP00000473047 | Kallikrein-11; Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin [...] |
| ZNF320 protein network | https://string-db.org/network/9606.ENSP00000473091 | Zinc finger protein 320; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MAGEA3 protein network | https://string-db.org/network/9606.ENSP00000473093 | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and [...] |
| ERVV-1 protein network | https://string-db.org/network/9606.ENSP00000473153 | Endogenous retrovirus group V member 1, envelope; Belongs to the gamma type-C retroviral envelope protein family |
| FFAR2 protein network | https://string-db.org/network/9606.ENSP00000473159 | Free fatty acid receptor 2; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulatio [...] |
| FAM231B protein network | https://string-db.org/network/9606.ENSP00000473163 | Family with sequence similarity 231, member B; Belongs to the FAM231 family |
| RUVBL2 protein network | https://string-db.org/network/9606.ENSP00000473172 | RuvB-like 2; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes; Belongs to the RuvB family |
| SEPW1 protein network | https://string-db.org/network/9606.ENSP00000473185 | Selenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity); B [...] |
| ENSG00000239665 protein network | https://string-db.org/network/9606.ENSP00000473200 | Protein LOC101928524 |
| GPR42 protein network | https://string-db.org/network/9606.ENSP00000473212 | G-protein coupled receptor 42; Probable G protein-coupled receptor that may be activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that may play a ro [...] |
| ENSG00000142539 protein network | https://string-db.org/network/9606.ENSP00000473233 | annotation not available |
| NELFCD protein network | https://string-db.org/network/9606.ENSP00000473290 | Negative elongation factor C/D; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via [...] |
| H6PD protein network | https://string-db.org/network/9606.ENSP00000473348 | GDH/6PGL endoplasmic bifunctional protein; Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates; In the C-terminal section; belongs to the glucosamine/galactosamine-6-ph [...] |
| MEI4 protein network | https://string-db.org/network/9606.ENSP00000473370 | Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and R [...] |
| OAZ1 protein network | https://string-db.org/network/9606.ENSP00000473381 | Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increa [...] |
| FBLL1 protein network | https://string-db.org/network/9606.ENSP00000473383 | rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA pro [...] |
| BIVM-ERCC5 protein network | https://string-db.org/network/9606.ENSP00000473384 | BIVM-ERCC5 readthrough |
| COMMD3-BMI1 protein network | https://string-db.org/network/9606.ENSP00000473391 | annotation not available |
| ENSG00000270136 protein network | https://string-db.org/network/9606.ENSP00000473411 | Neuroblastoma suppressor of tumorigenicity 1; MINOS1-NBL1 readthrough |
| SDR42E2 protein network | https://string-db.org/network/9606.ENSP00000473474 | Short chain dehydrogenase/reductase family 42E, member 2; Belongs to the 3-beta-HSD family |
| MAGEB5 protein network | https://string-db.org/network/9606.ENSP00000473493 | Melanoma-associated antigen B5; MAGE family member B5 |
| CSNK2A3 protein network | https://string-db.org/network/9606.ENSP00000473553 | Casein kinase II subunit alpha 3; Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic [...] |
| DENND4C protein network | https://string-db.org/network/9606.ENSP00000473565 | DENN domain-containing protein 4C; Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound fo [...] |
| DNAJC3 protein network | https://string-db.org/network/9606.ENSP00000473631 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by pr [...] |
| ENSG00000269948 protein network | https://string-db.org/network/9606.ENSP00000473658 | Protein CC2D2B |
| MTRNR2L6 protein network | https://string-db.org/network/9606.ENSP00000473686 | Humanin-like 6; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| EBLN1 protein network | https://string-db.org/network/9606.ENSP00000473842 | Endogenous Bornavirus-like nucleoprotein 1; May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity) |
| MMP28 protein network | https://string-db.org/network/9606.ENSP00000473853 | Matrix metalloproteinase-28; Can degrade casein. Could play a role in tissues homeostasis and repair; Belongs to the peptidase M10A family |
| FXYD3 protein network | https://string-db.org/network/9606.ENSP00000473929 | FXYD domain-containing ion transport regulator 3; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into [...] |
| HEATR9 protein network | https://string-db.org/network/9606.ENSP00000473941 | Protein HEATR9; Armadillo-like helical domain containing |
| TMEM120A protein network | https://string-db.org/network/9606.ENSP00000473983 | Transmembrane protein 120A; Necessary for efficient adipogenesis; Belongs to the TMEM120 family |
| ALDH3B1 protein network | https://string-db.org/network/9606.ENSP00000473990 | Aldehyde dehydrogenase family 3 member B1; Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyph [...] |
| TRIM77 protein network | https://string-db.org/network/9606.ENSP00000474003 | Tripartite motif containing 77; Belongs to the TRIM/RBCC family |
| DYNC2LI1 protein network | https://string-db.org/network/9606.ENSP00000474032 | Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioni [...] |
| CCDC120 protein network | https://string-db.org/network/9606.ENSP00000474071 | Coiled-coil domain-containing protein 120; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC68, cooperate wi [...] |
| UPP2 protein network | https://string-db.org/network/9606.ENSP00000474090 | Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized a [...] |
| TAF15 protein network | https://string-db.org/network/9606.ENSP00000474096 | TATA-binding protein-associated factor 2N; RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex to [...] |
| ENSG00000259680 protein network | https://string-db.org/network/9606.ENSP00000474135 | Uncharacterized protein |
| LEKR1 protein network | https://string-db.org/network/9606.ENSP00000474182 | Leucine-, glutamate- and lysine-rich protein 1; Leucine, glutamate and lysine rich 1 |
| RASL10B protein network | https://string-db.org/network/9606.ENSP00000474230 | Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small G [...] |
| IZUMO3 protein network | https://string-db.org/network/9606.ENSP00000474246 | Izumo sperm-egg fusion protein 3; IZUMO family member 3 |
| ADAM21 protein network | https://string-db.org/network/9606.ENSP00000474385 | Disintegrin and metalloproteinase domain-containing protein 21; May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing [...] |
| CTAGE6 protein network | https://string-db.org/network/9606.ENSP00000474388 | CTAGE family member 6 |
| CCL5 protein network | https://string-db.org/network/9606.ENSP00000474412 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several c [...] |
| NBPF1 protein network | https://string-db.org/network/9606.ENSP00000474456 | Neuroblastoma breakpoint family member 1; NBPF member 1 |
| LIX1L protein network | https://string-db.org/network/9606.ENSP00000474487 | LIX1-like protein; Limb and CNS expressed 1 like; Belongs to the LIX1 family |
| GAS2L2 protein network | https://string-db.org/network/9606.ENSP00000474529 | GAS2-like protein 2; Seems to be involved in the cross-linking of microtubules and microfilaments |
| HSPE1-MOB4 protein network | https://string-db.org/network/9606.ENSP00000474534 | HSPE1-MOB4 readthrough; Belongs to the GroES chaperonin family |
| HADH protein network | https://string-db.org/network/9606.ENSP00000474560 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-Co [...] |
| MTRNR2L13 protein network | https://string-db.org/network/9606.ENSP00000474570 | Humanin-like 13; Plays a role as a neuroprotective and antiapoptotic factor |
| CT45A2 protein network | https://string-db.org/network/9606.ENSP00000474632 | Cancer/testis antigen family 45 member A2 |
| ARMCX5 protein network | https://string-db.org/network/9606.ENSP00000474720 | Armadillo repeat containing, X-linked 5 |
| ENSG00000249884 protein network | https://string-db.org/network/9606.ENSP00000474823 | annotation not available |
| MTRNR2L9 protein network | https://string-db.org/network/9606.ENSP00000474840 | Humanin-like 9; Plays a role as a neuroprotective and antiapoptotic factor; Belongs to the humanin family |
| TRIM49D1 protein network | https://string-db.org/network/9606.ENSP00000474850 | Tripartite motif containing 49D1; Belongs to the TRIM/RBCC family |
| MTRNR2L11 protein network | https://string-db.org/network/9606.ENSP00000474861 | Humanin-like 11; Plays a role as a neuroprotective and antiapoptotic factor |
| TPBGL protein network | https://string-db.org/network/9606.ENSP00000474988 | Trophoblast glycoprotein like |
| TLX1NB protein network | https://string-db.org/network/9606.ENSP00000475001 | TLX1 neighbor |
| TLCD4-RWDD3 protein network | https://string-db.org/network/9606.ENSP00000475025 | TMEM56-RWDD3 readthrough |
| RPS10-NUDT3 protein network | https://string-db.org/network/9606.ENSP00000475027 | RPS10-NUDT3 readthrough |
| UGT2A2 protein network | https://string-db.org/network/9606.ENSP00000475028 | UDP glucuronosyltransferase 2 family, polypeptide A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid [...] |
| SMAGP protein network | https://string-db.org/network/9606.ENSP00000475068 | Small cell adhesion glycoprotein; May play a role in epithelial cell-cell contacts. May play a role in tumor invasiveness and metastasis formation |
| DUOX2 protein network | https://string-db.org/network/9606.ENSP00000475084 | Dual oxidase 2; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-me [...] |
| C17orf50 protein network | https://string-db.org/network/9606.ENSP00000475146 | Uncharacterized protein C17orf50; Chromosome 17 open reading frame 50 |
| RER1 protein network | https://string-db.org/network/9606.ENSP00000475168 | Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment |
| ANKRD34A protein network | https://string-db.org/network/9606.ENSP00000475189 | Ankyrin repeat domain-containing protein 34A; Ankyrin repeat domain containing; Belongs to the ANKRD34 family |
| KPRP protein network | https://string-db.org/network/9606.ENSP00000475216 | Keratinocyte proline rich protein |
| A3GALT2 protein network | https://string-db.org/network/9606.ENSP00000475261 | Alpha-1,3-galactosyltransferase 2; Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of [...] |
| LCE1C protein network | https://string-db.org/network/9606.ENSP00000475270 | Late cornified envelope protein 1C; Precursors of the cornified envelope of the stratum corneum |
| APLNR protein network | https://string-db.org/network/9606.ENSP00000475344 | Apelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early d [...] |
| ENSG00000275740 protein network | https://string-db.org/network/9606.ENSP00000475384 | RNA-binding protein 27 |
| CHURC1 protein network | https://string-db.org/network/9606.ENSP00000475473 | Protein Churchill; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement (By similarity). Does not bind DNA by itself |
| MPHOSPH9 protein network | https://string-db.org/network/9606.ENSP00000475489 | M-phase phosphoprotein 9 |
| OR2T7 protein network | https://string-db.org/network/9606.ENSP00000475521 | Olfactory receptor 2T7; Odorant receptor; Olfactory receptors, family 2 |
| ENSG00000242631 protein network | https://string-db.org/network/9606.ENSP00000475594 | Zinc finger protein 462 |
| CWC15 protein network | https://string-db.org/network/9606.ENSP00000475615 | Spliceosome-associated protein CWC15 homolog; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing |
| ENSG00000258881 protein network | https://string-db.org/network/9606.ENSP00000475641 | Uncharacterized protein |
| ENSG00000259316 protein network | https://string-db.org/network/9606.ENSP00000475686 | Casein kinase I isoform gamma-1 |
| TM2D1 protein network | https://string-db.org/network/9606.ENSP00000475700 | TM2 domain-containing protein 1; May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42 |
| ENSG00000204422 protein network | https://string-db.org/network/9606.ENSP00000475702 | Lymphocyte antigen 6 family member G6E |
| TBC1D7 protein network | https://string-db.org/network/9606.ENSP00000475727 | TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protei [...] |
| HEBP2 protein network | https://string-db.org/network/9606.ENSP00000475750 | Heme-binding protein 2; Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions |
| HIST2H2AA3 protein network | https://string-db.org/network/9606.ENSP00000475814 | Histone H2A type 2-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| CDC42SE1 protein network | https://string-db.org/network/9606.ENSP00000475845 | CDC42 small effector protein 1; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape ch [...] |
| CNKSR3 protein network | https://string-db.org/network/9606.ENSP00000475915 | Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport throug [...] |
| POLDIP2 protein network | https://string-db.org/network/9606.ENSP00000475924 | DNA polymerase delta interacting protein 2 |
| DNAH11 protein network | https://string-db.org/network/9606.ENSP00000475939 | Dynein heavy chain 11, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke [...] |
| DCP1A protein network | https://string-db.org/network/9606.ENSP00000476046 | mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7- methyl guanine cap structure from mRNA molecules [...] |
| GTF2H5 protein network | https://string-db.org/network/9606.ENSP00000476100 | General transcription factor IIH subunit 5; Component of the TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription [...] |
| WDR18 protein network | https://string-db.org/network/9606.ENSP00000476117 | WD repeat-containing protein 18; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoyla [...] |
| NUDT3 protein network | https://string-db.org/network/9606.ENSP00000476119 | Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol te [...] |
| HIST1H2BJ protein network | https://string-db.org/network/9606.ENSP00000476136 | Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| UQCC2 protein network | https://string-db.org/network/9606.ENSP00000476140 | Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b- [...] |
| MT1HL1 protein network | https://string-db.org/network/9606.ENSP00000476141 | Metallothionein 1H-like protein 1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals an [...] |
| FRK protein network | https://string-db.org/network/9606.ENSP00000476145 | Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr [...] |
| SLC37A4 protein network | https://string-db.org/network/9606.ENSP00000476176 | Glucose-6-phosphate exchanger SLC37A4; Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6- phosphate into the lumen of the endop [...] |
| ENSG00000271786 protein network | https://string-db.org/network/9606.ENSP00000476221 | Uncharacterized protein |
| SIRT5 protein network | https://string-db.org/network/9606.ENSP00000476228 | NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on tar [...] |
| ENSG00000271810 protein network | https://string-db.org/network/9606.ENSP00000476252 | Rho-related GTP-binding protein RhoC |
| SRRM5 protein network | https://string-db.org/network/9606.ENSP00000476253 | Serine/arginine repetitive matrix 5 |
| CDYL2 protein network | https://string-db.org/network/9606.ENSP00000476295 | Chromodomain Y like 2 |
| BHLHA15 protein network | https://string-db.org/network/9606.ENSP00000476312 | Class A basic helix-loop-helix protein 15; Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may [...] |
| OR8G1 protein network | https://string-db.org/network/9606.ENSP00000476313 | Olfactory receptor 8G1; Odorant receptor; Olfactory receptors, family 8 |
| FBXW2 protein network | https://string-db.org/network/9606.ENSP00000476369 | F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex; F-box and WD repeat domain containing |
| SCX protein network | https://string-db.org/network/9606.ENSP00000476384 | Basic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages; Basic hel [...] |
| ZBTB8B protein network | https://string-db.org/network/9606.ENSP00000476499 | Zinc finger and BTB domain-containing protein 8B; May be involved in transcriptional regulation; BTB domain containing |
| LYPD4 protein network | https://string-db.org/network/9606.ENSP00000476510 | LY6/PLAUR domain containing 4 |
| KCNN1 protein network | https://string-db.org/network/9606.ENSP00000476519 | Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...] |
| ENSG00000279624 protein network | https://string-db.org/network/9606.ENSP00000476535 | annotation not available |
| ENSG00000259060 protein network | https://string-db.org/network/9606.ENSP00000476537 | Ribonuclease A family member 11 |
| GPRIN3 protein network | https://string-db.org/network/9606.ENSP00000476603 | G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth |
| RPEL1 protein network | https://string-db.org/network/9606.ENSP00000476672 | Ribulose-phosphate 3-epimerase-like protein 1; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate |
| ENSG00000273049 protein network | https://string-db.org/network/9606.ENSP00000476742 | Uncharacterized protein |
| ZBTB25 protein network | https://string-db.org/network/9606.ENSP00000476746 | Zinc finger and BTB domain-containing protein 25; May be involved in transcriptional regulation; BTB domain containing |
| PPP1R12B protein network | https://string-db.org/network/9606.ENSP00000476755 | Protein phosphatase 1 regulatory subunit 12B; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus; Ankyrin repeat domain containing |
| FKBP8 protein network | https://string-db.org/network/9606.ENSP00000476767 | Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitoc [...] |
| ENSG00000263136 protein network | https://string-db.org/network/9606.ENSP00000476774 | PAXIP1-associated glutamate-rich protein 1; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in associa [...] |
| RGAG4 protein network | https://string-db.org/network/9606.ENSP00000476792 | Retrotransposon Gag-like protein 5; Retrotransposon gag domain containing 4 |
| GAN protein network | https://string-db.org/network/9606.ENSP00000476795 | Gigaxonin; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein li [...] |
| SLC25A16 protein network | https://string-db.org/network/9606.ENSP00000476815 | Graves disease carrier protein; Required for the accumulation of coenzyme A in the mitochondrial matrix; Solute carriers |
| TRABD2B protein network | https://string-db.org/network/9606.ENSP00000476820 | Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N- terminal residues of a subset of Wnt proteins. Followin [...] |
| KRTAP10-7 protein network | https://string-db.org/network/9606.ENSP00000476821 | Keratin-associated protein 10-7; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which [...] |
| RPAP2 protein network | https://string-db.org/network/9606.ENSP00000476948 | Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphoryl [...] |
| NCBP2L protein network | https://string-db.org/network/9606.ENSP00000476955 | Nuclear cap binding protein subunit 2 like; Belongs to the RRM NCBP2 family |
| HIST2H3PS2 protein network | https://string-db.org/network/9606.ENSP00000476960 | Histone cluster 2 H3 pseudogene 2 |
| OR8G5 protein network | https://string-db.org/network/9606.ENSP00000477014 | Olfactory receptor 8G5; Odorant receptor; Olfactory receptors, family 8 |
| SMIM5 protein network | https://string-db.org/network/9606.ENSP00000477017 | Small integral membrane protein 5 |
| ENSG00000241489 protein network | https://string-db.org/network/9606.ENSP00000477056 | Iduronate 2-sulfatase (Hunter syndrome), isoform CRA_e; Iduronate 2-sulfatase 14 kDa chain; Uncharacterized protein; cDNA FLJ42669 fis, clone BRAMY2022168, highly similar to IDURONATE 2-SULFATASE [...] |
| XKR7 protein network | https://string-db.org/network/9606.ENSP00000477059 | XK-related protein 7; XK related family |
| FRRS1L protein network | https://string-db.org/network/9606.ENSP00000477141 | DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway |
| APBB1 protein network | https://string-db.org/network/9606.ENSP00000477213 | Amyloid-beta A4 precursor protein-binding family B member 1; Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally act [...] |
| DYNLL2 protein network | https://string-db.org/network/9606.ENSP00000477310 | Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to [...] |
| PCDHB16 protein network | https://string-db.org/network/9606.ENSP00000477314 | Protocadherin beta-16; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadher [...] |
| PPM1K protein network | https://string-db.org/network/9606.ENSP00000477341 | Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development; Belongs to the PP2C family |
| SYT6 protein network | https://string-db.org/network/9606.ENSP00000477344 | Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of ves [...] |
| SCOC protein network | https://string-db.org/network/9606.ENSP00000477352 | Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family |
| ZNF595 protein network | https://string-db.org/network/9606.ENSP00000477392 | Zinc finger protein 595; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| KCNJ6 protein network | https://string-db.org/network/9606.ENSP00000477437 | G protein-activated inward rectifier potassium channel 2; This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protei [...] |
| OR10G6 protein network | https://string-db.org/network/9606.ENSP00000477445 | Olfactory receptor 10G6; Odorant receptor; Olfactory receptors, family 10 |
| GRIN2B protein network | https://string-db.org/network/9606.ENSP00000477455 | Glutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sens [...] |
| NOMO2 protein network | https://string-db.org/network/9606.ENSP00000477502 | Nodal modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN |
| C14orf169 protein network | https://string-db.org/network/9606.ENSP00000477507 | Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of hist [...] |
| NBPF11 protein network | https://string-db.org/network/9606.ENSP00000477509 | Neuroblastoma breakpoint family member 11; NBPF member 11; Belongs to the NBPF family |
| DGKK protein network | https://string-db.org/network/9606.ENSP00000477515 | Diacylglycerol kinase kappa; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) |
| HIST1H2BO protein network | https://string-db.org/network/9606.ENSP00000477527 | Histone H2B type 1-O; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| F8A3 protein network | https://string-db.org/network/9606.ENSP00000477530 | Coagulation factor VIII-associated 3; Not known. Possible housekeeping role |
| NAP1L1 protein network | https://string-db.org/network/9606.ENSP00000477538 | Nucleosome assembly protein 1-like 1; May be involved in modulating chromatin formation and contribute to regulation of cell proliferation; Belongs to the nucleosome assembly protein (NAP) family |
| HCRTR2 protein network | https://string-db.org/network/9606.ENSP00000477548 | Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding; Hypoc [...] |
| MR1 protein network | https://string-db.org/network/9606.ENSP00000477563 | Major histocompatibility complex class I-related gene protein; Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of [...] |
| SCARF2 protein network | https://string-db.org/network/9606.ENSP00000477564 | Scavenger receptor class F member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of a [...] |
| CYP4F8 protein network | https://string-db.org/network/9606.ENSP00000477567 | Cytochrome P450 4F8; Hydroxylates arachidonic acid (20:4n-6) to (18R)- hydroxyarachidonate. Shows little activity against prostaglandin (PG) D2, PGE1, PGE2, PGF2alpha, and leukotriene B4. Catalyz [...] |
| HMOX2 protein network | https://string-db.org/network/9606.ENSP00000477572 | Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiologic [...] |
| SRD5A2 protein network | https://string-db.org/network/9606.ENSP00000477587 | 3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It pl [...] |
| CPNE3 protein network | https://string-db.org/network/9606.ENSP00000477590 | Copine-3; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation; Belongs to the copine family |
| ENSG00000273154 protein network | https://string-db.org/network/9606.ENSP00000477596 | annotation not available |
| MROH2A protein network | https://string-db.org/network/9606.ENSP00000477597 | Maestro heat like repeat family member 2A |
| ELOVL1 protein network | https://string-db.org/network/9606.ENSP00000477602 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic retic [...] |
| BIRC2 protein network | https://string-db.org/network/9606.ENSP00000477613 | Baculoviral IAP repeat-containing protein 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase sig [...] |
| TMC4 protein network | https://string-db.org/network/9606.ENSP00000477627 | Transmembrane channel-like protein 4; Probable ion channel; Transmembrane channel likes |
| NAGK protein network | https://string-db.org/network/9606.ENSP00000477639 | N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosph [...] |
| DUSP14 protein network | https://string-db.org/network/9606.ENSP00000477653 | Dual specificity protein phosphatase 14; Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases; Atypical dual specificity phosphatases |
| C18orf54 protein network | https://string-db.org/network/9606.ENSP00000477654 | Lung adenoma susceptibility protein 2; Might play a role in cell proliferation |
| AQP6 protein network | https://string-db.org/network/9606.ENSP00000477688 | Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism; Aquaporins |
| ANKRD20A1 protein network | https://string-db.org/network/9606.ENSP00000477695 | Ankyrin repeat domain-containing protein 20A1; Ankyrin repeat domain 20 family member A1 |
| ZNF316 protein network | https://string-db.org/network/9606.ENSP00000477706 | Zinc finger protein 316; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| NR1H3 protein network | https://string-db.org/network/9606.ENSP00000477707 | Oxysterols receptor LXR-alpha; Nuclear receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses [...] |
| CPEB1 protein network | https://string-db.org/network/9606.ENSP00000477715 | Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, e [...] |
| ZNF8 protein network | https://string-db.org/network/9606.ENSP00000477716 | Zinc finger protein 8; Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins; Belongs to the krueppel C2H2-type zinc-finger prot [...] |
| KANK1 protein network | https://string-db.org/network/9606.ENSP00000477725 | KN motif and ankyrin repeat domain-containing protein 1; Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. I [...] |
| ANAPC16 protein network | https://string-db.org/network/9606.ENSP00000477760 | Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| SRGAP2B protein network | https://string-db.org/network/9606.ENSP00000477776 | SLIT-ROBO Rho GTPase-activating protein 2B; May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2; F-BAR domain containing |
| TPT1 protein network | https://string-db.org/network/9606.ENSP00000477781 | Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization |
| LRRC41 protein network | https://string-db.org/network/9606.ENSP00000477792 | Leucine-rich repeat-containing protein 41; Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination an [...] |
| C1orf158 protein network | https://string-db.org/network/9606.ENSP00000477802 | Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158 |
| PTCRA protein network | https://string-db.org/network/9606.ENSP00000477815 | Pre T-cell antigen receptor alpha; The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development |
| PTPDC1 protein network | https://string-db.org/network/9606.ENSP00000477817 | Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance; CDC14 phosphatases |
| LHX1 protein network | https://string-db.org/network/9606.ENSP00000477829 | LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis; LIM class homeoboxes |
| ZNF282 protein network | https://string-db.org/network/9606.ENSP00000477841 | Zinc finger protein 282; Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and ex [...] |
| CLEC18C protein network | https://string-db.org/network/9606.ENSP00000477846 | C-type lectin domain family 18 member C; Binds polysaccharidesin a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containing |
| AATF protein network | https://string-db.org/network/9606.ENSP00000477848 | Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F tar [...] |
| GGTLC3 protein network | https://string-db.org/network/9606.ENSP00000477856 | Gamma-glutamyltransferase light chain family member 3; Gamma-glutamyltransferases |
| TOX4 protein network | https://string-db.org/network/9606.ENSP00000477868 | TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transitio [...] |
| HIST1H4G protein network | https://string-db.org/network/9606.ENSP00000477870 | Histone H4-like protein type G; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a templa [...] |
| HIST1H2BM protein network | https://string-db.org/network/9606.ENSP00000477907 | Histone H2B type 1-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| CCL3 protein network | https://string-db.org/network/9606.ENSP00000477908 | C-C motif chemokine 3; Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-a [...] |
| GIMAP5 protein network | https://string-db.org/network/9606.ENSP00000477920 | GTPase IMAP family member 5; Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence (By similarity); GTPases, IMAP |
| SSX2B protein network | https://string-db.org/network/9606.ENSP00000477922 | Synovial sarcoma, X breakpoint 2B; SSX family member 2B |
| TMPRSS4 protein network | https://string-db.org/network/9606.ENSP00000477949 | Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC (By similarity); Scavenger receptor cysteine rich domain containing |
| STAG3 protein network | https://string-db.org/network/9606.ENSP00000477973 | Cohesin subunit SA-3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently fo [...] |
| NBPF9 protein network | https://string-db.org/network/9606.ENSP00000477979 | Neuroblastoma breakpoint family member 20; NBPF member 9; Belongs to the NBPF family |
| ENSG00000273398 protein network | https://string-db.org/network/9606.ENSP00000477980 | WD repeat-containing protein 92; Seems to act as a modulator of apoptosis; WD repeat domain containing |
| SLC25A14 protein network | https://string-db.org/network/9606.ENSP00000477981 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family |
| NOS1 protein network | https://string-db.org/network/9606.ENSP00000477999 | Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many pro [...] |
| LOC649330 protein network | https://string-db.org/network/9606.ENSP00000478017 | Heterogeneous nuclear ribonucleoprotein C-like |
| CCL16 protein network | https://string-db.org/network/9606.ENSP00000478024 | C-C motif chemokine 16; Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor c [...] |
| ANXA8 protein network | https://string-db.org/network/9606.ENSP00000478026 | Annexin A8; Annexins |
| ENSG00000214026 protein network | https://string-db.org/network/9606.ENSP00000478035 | Mitochondrial ribosomal protein L23 |
| STIM1 protein network | https://string-db.org/network/9606.ENSP00000478059 | Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endo [...] |
| MARCKS protein network | https://string-db.org/network/9606.ENSP00000478061 | Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F [...] |
| CWC25 protein network | https://string-db.org/network/9606.ENSP00000478070 | CWC25 spliceosome associated protein homolog; Spliceosomal Bact complex |
| VPS13D protein network | https://string-db.org/network/9606.ENSP00000478104 | Vacuolar protein sorting 13 homolog D; Belongs to the VPS13 family |
| TCEB1 protein network | https://string-db.org/network/9606.ENSP00000478121 | Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A [...] |
| CASP8AP2 protein network | https://string-db.org/network/9606.ENSP00000478179 | CASP8-associated protein 2; Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- [...] |
| CRY2 protein network | https://string-db.org/network/9606.ENSP00000478187 | Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes thr [...] |
| AKAP1 protein network | https://string-db.org/network/9606.ENSP00000478212 | A-kinase anchor protein 1, mitochondrial; Binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane; A-kinase anc [...] |
| GGNBP2 protein network | https://string-db.org/network/9606.ENSP00000478220 | Gametogenetin-binding protein 2; May be involved in spermatogenesis |
| MTHFD1L protein network | https://string-db.org/network/9606.ENSP00000478253 | Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon fol [...] |
| ABCB1 protein network | https://string-db.org/network/9606.ENSP00000478255 | Multidrug resistance protein 1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; ATP binding cassette subfamily B |
| CCNI2 protein network | https://string-db.org/network/9606.ENSP00000478257 | Cyclin-I2; Cyclin I family member 2; Cyclins |
| PCDHGB5 protein network | https://string-db.org/network/9606.ENSP00000478258 | Protocadherin gamma-B5; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadhe [...] |
| IGHV4-38-2 protein network | https://string-db.org/network/9606.ENSP00000478289 | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoprotei [...] |
| SRGAP2C protein network | https://string-db.org/network/9606.ENSP00000478290 | SLIT-ROBO Rho GTPase-activating protein 2C; Involved in dendritic spine maturation through interaction with and inhibition of SRGAP2. Reduces the rate of spine maturation and indirectly increases [...] |
| SPPL2B protein network | https://string-db.org/network/9606.ENSP00000478298 | Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and [...] |
| POLR2E protein network | https://string-db.org/network/9606.ENSP00000478303 | DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Com [...] |
| SMOX protein network | https://string-db.org/network/9606.ENSP00000478305 | Spermine oxidase; Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isof [...] |
| PRAMEF26 protein network | https://string-db.org/network/9606.ENSP00000478309 | Belongs to the PRAME family |
| SPCS1 protein network | https://string-db.org/network/9606.ENSP00000478310 | Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endopla [...] |
| GREM1 protein network | https://string-db.org/network/9606.ENSP00000478319 | Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining [...] |
| ATXN3 protein network | https://string-db.org/network/9606.ENSP00000478320 | Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long pol [...] |
| ZNF714 protein network | https://string-db.org/network/9606.ENSP00000478345 | Zinc finger protein 714; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FOXI3 protein network | https://string-db.org/network/9606.ENSP00000478384 | Forkhead box protein I3; Possible transcriptional factor |
| NATD1 protein network | https://string-db.org/network/9606.ENSP00000478388 | Protein NATD1; N-acetyltransferase domain containing 1 |
| TTI2 protein network | https://string-db.org/network/9606.ENSP00000478396 | TELO2-interacting protein 2; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein [...] |
| PPP6R2 protein network | https://string-db.org/network/9606.ENSP00000478417 | Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphor [...] |
| MT1A protein network | https://string-db.org/network/9606.ENSP00000478425 | Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoi [...] |
| TBC1D3D protein network | https://string-db.org/network/9606.ENSP00000478426 | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| PLCL2 protein network | https://string-db.org/network/9606.ENSP00000478458 | Inactive phospholipase C-like protein 2; May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum; C2 domain containing phospholipases |
| UBE2F protein network | https://string-db.org/network/9606.ENSP00000478474 | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3- NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the [...] |
| GOLGA6L1 protein network | https://string-db.org/network/9606.ENSP00000478478 | Golgin subfamily A member 6-like protein 1; Golgin A6 family-like 1; Belongs to the GOLGA6 family |
| RAB18 protein network | https://string-db.org/network/9606.ENSP00000478479 | Ras-related protein Rab-18; RAB18, member RAS oncogene family |
| YTHDF3 protein network | https://string-db.org/network/9606.ENSP00000478490 | YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs and promotes RNA translation efficiency. M6A is a modification present at intern [...] |
| CYSLTR1 protein network | https://string-db.org/network/9606.ENSP00000478492 | Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and prol [...] |
| ANAPC10 protein network | https://string-db.org/network/9606.ENSP00000478501 | Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the [...] |
| NLRP1 protein network | https://string-db.org/network/9606.ENSP00000478516 | NACHT, LRR and PYD domains-containing protein 1; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other da [...] |
| ZNF274 protein network | https://string-db.org/network/9606.ENSP00000478533 | Neurotrophin receptor-interacting factor homolog; Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such [...] |
| ZNF787 protein network | https://string-db.org/network/9606.ENSP00000478557 | Zinc finger protein 787; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CYP1B1 protein network | https://string-db.org/network/9606.ENSP00000478561 | Cytochrome P450 1B1; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| GAGE2E protein network | https://string-db.org/network/9606.ENSP00000478568 | G antigen 2E |
| VEGFA protein network | https://string-db.org/network/9606.ENSP00000478570 | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits a [...] |
| TTC25 protein network | https://string-db.org/network/9606.ENSP00000478589 | Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility; Tetratricopeptide repeat domain containing |
| NEURL3 protein network | https://string-db.org/network/9606.ENSP00000478591 | E3 ubiquitin-protein ligase NEURL3; E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not invo [...] |
| LEPREL2 protein network | https://string-db.org/network/9606.ENSP00000478600 | Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-l [...] |
| PCDHB9 protein network | https://string-db.org/network/9606.ENSP00000478606 | Protocadherin beta-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadheri [...] |
| NBPF12 protein network | https://string-db.org/network/9606.ENSP00000478609 | Neuroblastoma breakpoint family member 1; NBPF member 12 |
| ENSG00000263020 protein network | https://string-db.org/network/9606.ENSP00000478610 | Chimera CSNK2B-LY6G5B splicing isoform 991 |
| SYT16 protein network | https://string-db.org/network/9606.ENSP00000478637 | Synaptotagmin-16; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Synaptotagmins |
| SLC1A7 protein network | https://string-db.org/network/9606.ENSP00000478639 | Amino acid transporter; Solute carrier family 1 member 7 |
| ICA1L protein network | https://string-db.org/network/9606.ENSP00000478645 | Islet cell autoantigen 1-like protein; Classical BAR domain containing |
| CNTNAP3B protein network | https://string-db.org/network/9606.ENSP00000478671 | Contactin-associated protein-like 3B; Contactin associated protein like 3B |
| RAG2 protein network | https://string-db.org/network/9606.ENSP00000478672 | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles [...] |
| TBC1D3 protein network | https://string-db.org/network/9606.ENSP00000478683 | TBC1 domain family, member 3; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 |
| TNFRSF9 protein network | https://string-db.org/network/9606.ENSP00000478699 | Tumor necrosis factor receptor superfamily member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation; CD molecules |
| RYK protein network | https://string-db.org/network/9606.ENSP00000478721 | Tyrosine-protein kinase RYK; May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establish [...] |
| IGHV3-11 protein network | https://string-db.org/network/9606.ENSP00000478725 | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoprotei [...] |
| NBPF19 protein network | https://string-db.org/network/9606.ENSP00000478752 | Neuroblastoma breakpoint family, member 14; Belongs to the NBPF family |
| DDX6 protein network | https://string-db.org/network/9606.ENSP00000478754 | Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-rela [...] |
| SEC14L2 protein network | https://string-db.org/network/9606.ENSP00000478755 | SEC14-like protein 2; Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also bin [...] |
| PPP1R9B protein network | https://string-db.org/network/9606.ENSP00000478767 | Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and sh [...] |
| LTN1 protein network | https://string-db.org/network/9606.ENSP00000478783 | E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extractio [...] |
| POTEB3 protein network | https://string-db.org/network/9606.ENSP00000478796 | POTE ankyrin domain family member B |
| PTMS protein network | https://string-db.org/network/9606.ENSP00000478828 | Parathymosin; Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections |
| TMPRSS7 protein network | https://string-db.org/network/9606.ENSP00000478830 | Transmembrane protease serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position; Belongs to the peptidase S1 family |
| TEX28 protein network | https://string-db.org/network/9606.ENSP00000478834 | Testis-specific protein TEX28; Testis expressed 28; Belongs to the TEX28 family |
| CAMK1D protein network | https://string-db.org/network/9606.ENSP00000478874 | Calcium/calmodulin-dependent protein kinase type 1D; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, act [...] |
| ADRM1 protein network | https://string-db.org/network/9606.ENSP00000478877 | Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| CPNE4 protein network | https://string-db.org/network/9606.ENSP00000478878 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family |
| C17orf78 protein network | https://string-db.org/network/9606.ENSP00000478886 | Uncharacterized protein C17orf78; Chromosome 17 open reading frame 78 |
| GNAZ protein network | https://string-db.org/network/9606.ENSP00000478892 | Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems |
| ENSG00000274847 protein network | https://string-db.org/network/9606.ENSP00000478910 | annotation not available |
| YAP1 protein network | https://string-db.org/network/9606.ENSP00000478927 | Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway t [...] |
| AIFM2 protein network | https://string-db.org/network/9606.ENSP00000478931 | Apoptosis-inducing factor 2; Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial e [...] |
| LOC102724488 protein network | https://string-db.org/network/9606.ENSP00000478933 | Uncharacterized protein; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues; Synaptotagmins |
| ENSG00000233757 protein network | https://string-db.org/network/9606.ENSP00000478941 | annotation not available |
| UPK1A protein network | https://string-db.org/network/9606.ENSP00000478942 | Uroplakin-1a; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal blad [...] |
| CBY1 protein network | https://string-db.org/network/9606.ENSP00000478962 | Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF tran [...] |
| USP17L15 protein network | https://string-db.org/network/9606.ENSP00000478980 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 15; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may includ [...] |
| RPP38 protein network | https://string-db.org/network/9606.ENSP00000478982 | Ribonuclease P protein subunit p38; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. RPP38 may associate transiently with RNase P RNA [...] |
| GPHB5 protein network | https://string-db.org/network/9606.ENSP00000478993 | Glycoprotein hormone beta-5; Functions as a heterodimeric glycoprotein hormone with GPHA2 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP prod [...] |
| CCDC28A protein network | https://string-db.org/network/9606.ENSP00000479060 | Coiled-coil domain containing 28A |
| GJA9-MYCBP protein network | https://string-db.org/network/9606.ENSP00000479064 | Uncharacterized protein; GJA9-MYCBP readthrough |
| ELOA3B protein network | https://string-db.org/network/9606.ENSP00000479069 | SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcr [...] |
| OSCAR protein network | https://string-db.org/network/9606.ENSP00000479089 | Osteoclast-associated immunoglobulin-like receptor; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation; Belongs to the leukocyte recepto [...] |
| CCL14 protein network | https://string-db.org/network/9606.ENSP00000479097 | C-C motif chemokine ligand 14 |
| ENC1 protein network | https://string-db.org/network/9606.ENSP00000479101 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor [...] |
| SVOP protein network | https://string-db.org/network/9606.ENSP00000479104 | Synaptic vesicle 2-related protein; SV2 related protein |
| HIST1H4A protein network | https://string-db.org/network/9606.ENSP00000479106 | Histone cluster 1 H4 family member a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| GABRG3 protein network | https://string-db.org/network/9606.ENSP00000479113 | Gamma-aminobutyric acid receptor subunit gamma-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor [...] |
| ENSG00000278782 protein network | https://string-db.org/network/9606.ENSP00000479119 | annotation not available |
| ACSF3 protein network | https://string-db.org/network/9606.ENSP00000479130 | Acyl-CoA synthetase family member 3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into the [...] |
| FMN1 protein network | https://string-db.org/network/9606.ENSP00000479134 | Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables; Belongs to the formin homology family. Cappuccino subfamily |
| A26B3 protein network | https://string-db.org/network/9606.ENSP00000479139 | Homo sapiens POTE ankyrin domain family member D-like (LOC100288966), mRNA |
| EHD1 protein network | https://string-db.org/network/9606.ENSP00000479153 | EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts i [...] |
| PRH1 protein network | https://string-db.org/network/9606.ENSP00000479168 | Uncharacterized protein; PRP's act as highly potent inhibitors of crystal growth of calcium phosphates. They provide a protective and reparative environment for dental enamel which is important f [...] |
| HIST1H2BH protein network | https://string-db.org/network/9606.ENSP00000479169 | Histone H2B type 1-H; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| HNRNPCP5 protein network | https://string-db.org/network/9606.ENSP00000479203 | Heterogeneous nuclear ribonucleoprotein C-like 2; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs |
| TCEB3CL protein network | https://string-db.org/network/9606.ENSP00000479206 | Putative elongin-A3 member C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresti [...] |
| GALNTL5 protein network | https://string-db.org/network/9606.ENSP00000479207 | Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5; Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acr [...] |
| UBXN8 protein network | https://string-db.org/network/9606.ENSP00000479216 | UBX domain-containing protein 8; Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. M [...] |
| PINLYP protein network | https://string-db.org/network/9606.ENSP00000479240 | Phospholipase A2 inhibitor and LY6/PLAUR domain containing; Belongs to the CNF-like-inhibitor family |
| ECSCR protein network | https://string-db.org/network/9606.ENSP00000479243 | Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilita [...] |
| JAKMIP2 protein network | https://string-db.org/network/9606.ENSP00000479248 | Janus kinase and microtubule interacting protein 2; Belongs to the JAKMIP family |
| TRIL protein network | https://string-db.org/network/9606.ENSP00000479256 | TLR4 interactor with leucine rich repeats; Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion |
| PANO protein network | https://string-db.org/network/9606.ENSP00000479258 | Proapoptotic nucleolar protein 1; Apoptosis-inducing protein that modulates the tumor suppressor function of CDKN2A/p14ARF. Enhances the stability of CDKN2A/p14ARF protein by protecting it from d [...] |
| BORA protein network | https://string-db.org/network/9606.ENSP00000479266 | Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis |
| FLJ44313 protein network | https://string-db.org/network/9606.ENSP00000479281 | Uncharacterized protein LOC400658 |
| HIST3H2BB protein network | https://string-db.org/network/9606.ENSP00000479284 | Histone H2B type 3-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| NBPF8 protein network | https://string-db.org/network/9606.ENSP00000479291 | Neuroblastoma breakpoint family member 20; NBPF member 8 |
| CLIP1 protein network | https://string-db.org/network/9606.ENSP00000479322 | CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. [...] |
| RIMBP3B protein network | https://string-db.org/network/9606.ENSP00000479326 | Probable component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development |
| LENG9 protein network | https://string-db.org/network/9606.ENSP00000479355 | Leukocyte receptor cluster member 9 |
| GOLGA6L10 protein network | https://string-db.org/network/9606.ENSP00000479362 | Golgin subfamily A member 6-like protein 10; Golgin A6 family-like 10; Belongs to the GOLGA6 family |
| HNRNPCL1 protein network | https://string-db.org/network/9606.ENSP00000479365 | Heterogeneous nuclear ribonucleoprotein C-like 1; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs; RNA binding motif containing |
| GUCD1 protein network | https://string-db.org/network/9606.ENSP00000479370 | Protein GUCD1; Guanylyl cyclase domain containing 1 |
| ENSG00000274175 protein network | https://string-db.org/network/9606.ENSP00000479378 | annotation not available |
| C17orf98 protein network | https://string-db.org/network/9606.ENSP00000479396 | Uncharacterized protein C17orf98; Chromosome 17 open reading frame 98 |
| ZNF700 protein network | https://string-db.org/network/9606.ENSP00000479449 | Zinc finger protein 700; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| HIST1H4D protein network | https://string-db.org/network/9606.ENSP00000479461 | Histone cluster 1 H4 family member d; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| PHB protein network | https://string-db.org/network/9606.ENSP00000479488 | Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitoc [...] |
| PCID2 protein network | https://string-db.org/network/9606.ENSP00000479494 | PCI domain containing 2; Transcription and export complex 2 |
| DDX52 protein network | https://string-db.org/network/9606.ENSP00000479504 | Probable ATP-dependent RNA helicase DDX52; DExD-box helicase 52; Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily |
| MYO19 protein network | https://string-db.org/network/9606.ENSP00000479518 | Unconventional myosin-XIX; Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments (By [...] |
| DPF3 protein network | https://string-db.org/network/9606.ENSP00000479526 | Zinc finger protein DPF3; Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodel [...] |
| CD177 protein network | https://string-db.org/network/9606.ENSP00000479536 | CD177 antigen; In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production. I [...] |
| KIZ protein network | https://string-db.org/network/9606.ENSP00000479542 | Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle forma [...] |
| GIMAP6 protein network | https://string-db.org/network/9606.ENSP00000479580 | GTPase, IMAP family member 6 |
| LYNX1 protein network | https://string-db.org/network/9606.ENSP00000479586 | Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent [...] |
| RHNO1 protein network | https://string-db.org/network/9606.ENSP00000479598 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1; Plays a role in DNA damage response (DDR) signaling upon genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to [...] |
| CLTC protein network | https://string-db.org/network/9606.ENSP00000479606 | Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma me [...] |
| ENSG00000278289 protein network | https://string-db.org/network/9606.ENSP00000479608 | Cancer/testis antigen family 45 member A6 |
| UHRF1 protein network | https://string-db.org/network/9606.ENSP00000479617 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethyl [...] |
| MYC protein network | https://string-db.org/network/9606.ENSP00000479618 | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growt [...] |
| F8A1 protein network | https://string-db.org/network/9606.ENSP00000479624 | Factor VIII intron 22 protein; Not known. Possible housekeeping role |
| PLCD3 protein network | https://string-db.org/network/9606.ENSP00000479636 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and in [...] |
| KRTAP7-1 protein network | https://string-db.org/network/9606.ENSP00000479656 | Keratin-associated protein 7-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which a [...] |
| AOAH protein network | https://string-db.org/network/9606.ENSP00000479664 | Acyloxyacyl hydrolase; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides. By breaking down LPS, terminates the host response to [...] |
| RPS6KA5 protein network | https://string-db.org/network/9606.ENSP00000479667 | Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the reg [...] |
| CAB39L protein network | https://string-db.org/network/9606.ENSP00000479669 | Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO [...] |
| IGHV3-15 protein network | https://string-db.org/network/9606.ENSP00000479675 | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoprotei [...] |
| KCP protein network | https://string-db.org/network/9606.ENSP00000479679 | Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity) |
| NBPF26 protein network | https://string-db.org/network/9606.ENSP00000479693 | Neuroblastoma breakpoint family member 14; NBPF member 14 |
| MAL2 protein network | https://string-db.org/network/9606.ENSP00000479708 | Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order [...] |
| DNAJC28 protein network | https://string-db.org/network/9606.ENSP00000479716 | DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone; DNAJ heat shock proteins |
| LRCOL1 protein network | https://string-db.org/network/9606.ENSP00000479730 | Leucine-rich colipase-like protein 1; Leucine rich colipase like 1 |
| PRSS56 protein network | https://string-db.org/network/9606.ENSP00000479745 | Serine protease 56; Serine protease required during eye development |
| RAB7B protein network | https://string-db.org/network/9606.ENSP00000479762 | Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL [...] |
| CFAP57 protein network | https://string-db.org/network/9606.ENSP00000479773 | Cilia and flagella associated protein 57 |
| HIST1H4K protein network | https://string-db.org/network/9606.ENSP00000479794 | Histone cluster 1 H4 family member k; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| CNTNAP4 protein network | https://string-db.org/network/9606.ENSP00000479811 | Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory [...] |
| DENND1B protein network | https://string-db.org/network/9606.ENSP00000479816 | DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchang [...] |
| RASGRP4 protein network | https://string-db.org/network/9606.ENSP00000479844 | RAS guanyl-releasing protein 4; Functions as a cation- and diacylglycerol (DAG)- regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mas [...] |
| ALG1L2 protein network | https://string-db.org/network/9606.ENSP00000479850 | Putative glycosyltransferase ALG1L2; Putative glycosyltransferase; Glycosyl transferases group 1 domain containing |
| CIB1 protein network | https://string-db.org/network/9606.ENSP00000479860 | Calcium and integrin binding 1; EF-hand domain containing |
| SEPT2 protein network | https://string-db.org/network/9606.ENSP00000479861 | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPT12, SEPT6, SEPT2 and probably SEPT4 at the sperm annulus which is required for the structural integrity and [...] |
| ALOX5AP protein network | https://string-db.org/network/9606.ENSP00000479870 | Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essentia [...] |
| ZNF229 protein network | https://string-db.org/network/9606.ENSP00000479884 | Zinc finger protein 229; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ZMYM2 protein network | https://string-db.org/network/9606.ENSP00000479904 | Zinc finger MYM-type protein 2; May function as a transcription factor; Zinc fingers MYM-type |
| MLLT6 protein network | https://string-db.org/network/9606.ENSP00000479910 | Protein AF-17; MLLT6, PHD finger containing |
| SH3GLB1 protein network | https://string-db.org/network/9606.ENSP00000479919 | Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins t [...] |
| ENSG00000273748 protein network | https://string-db.org/network/9606.ENSP00000479921 | annotation not available |
| LRRC8E protein network | https://string-db.org/network/9606.ENSP00000479953 | Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cel [...] |
| CCL18 protein network | https://string-db.org/network/9606.ENSP00000479955 | C-C motif chemokine 18; Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T- [...] |
| SLC4A1AP protein network | https://string-db.org/network/9606.ENSP00000479964 | Kanadaptin; Solute carrier family 4 member 1 adaptor protein |
| C19orf80 protein network | https://string-db.org/network/9606.ENSP00000479969 | Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: requi [...] |
| C11orf96 protein network | https://string-db.org/network/9606.ENSP00000479976 | Uncharacterized protein C11orf96; Chromosome 11 open reading frame 96 |
| EPHX1 protein network | https://string-db.org/network/9606.ENSP00000480004 | Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By [...] |
| ENSG00000258555 protein network | https://string-db.org/network/9606.ENSP00000480012 | annotation not available |
| HEMGN protein network | https://string-db.org/network/9606.ENSP00000480020 | Hemogen; Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell [...] |
| PRAMEF11 protein network | https://string-db.org/network/9606.ENSP00000480027 | Belongs to the PRAME family |
| VEGFC protein network | https://string-db.org/network/9606.ENSP00000480043 | Vascular endothelial growth factor C; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of [...] |
| SYN2 protein network | https://string-db.org/network/9606.ENSP00000480050 | Synapsin-2; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradren [...] |
| GPIHBP1 protein network | https://string-db.org/network/9606.ENSP00000480053 | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LP [...] |
| METTL8 protein network | https://string-db.org/network/9606.ENSP00000480056 | Methyltransferase-like protein 8; Probable methyltransferase; Belongs to the methyltransferase superfamily. METL family |
| P3R3URF protein network | https://string-db.org/network/9606.ENSP00000480059 | annotation not available |
| ENSG00000273554 protein network | https://string-db.org/network/9606.ENSP00000480079 | annotation not available |
| PKD1L3 protein network | https://string-db.org/network/9606.ENSP00000480090 | Polycystic kidney disease protein 1-like 3; Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution [...] |
| NMRK2 protein network | https://string-db.org/network/9606.ENSP00000480091 | Nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucl [...] |
| PRAMEF5 protein network | https://string-db.org/network/9606.ENSP00000480122 | PRAME family member 5; Belongs to the PRAME family |
| NCAM1 protein network | https://string-db.org/network/9606.ENSP00000480132 | Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc; CD molecules |
| SRSF8 protein network | https://string-db.org/network/9606.ENSP00000480140 | Serine/arginine-rich splicing factor 8; Involved in pre-mRNA alternative splicing; Serine and arginine rich splicing factors |
| HYOU1 protein network | https://string-db.org/network/9606.ENSP00000480150 | Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein foldi [...] |
| PIK3R6 protein network | https://string-db.org/network/9606.ENSP00000480157 | Phosphoinositide 3-kinase regulatory subunit 6; Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 he [...] |
| POLR2A protein network | https://string-db.org/network/9606.ENSP00000480158 | DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and cataly [...] |
| POLD2 protein network | https://string-db.org/network/9606.ENSP00000480186 | DNA polymerase delta subunit 2; As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replic [...] |
| ZNF761 protein network | https://string-db.org/network/9606.ENSP00000480218 | Zinc finger protein 761; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ANXA8L1 protein network | https://string-db.org/network/9606.ENSP00000480221 | Annexin A8 like 1; Belongs to the annexin family |
| ZNF48 protein network | https://string-db.org/network/9606.ENSP00000480262 | Zinc finger protein 48; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| USH1G protein network | https://string-db.org/network/9606.ENSP00000480279 | Usher syndrome type-1G protein; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH [...] |
| HNF1B protein network | https://string-db.org/network/9606.ENSP00000480291 | Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family |
| ZNF2 protein network | https://string-db.org/network/9606.ENSP00000480297 | Zinc finger protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| IQSEC1 protein network | https://string-db.org/network/9606.ENSP00000480301 | IQ motif and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP bind [...] |
| GATD3B protein network | https://string-db.org/network/9606.ENSP00000480313 | Belongs to the GATD3 family |
| C19orf68 protein network | https://string-db.org/network/9606.ENSP00000480314 | Uncharacterized protein ZSWIM9; Chromosome 19 open reading frame 68 |
| TUBGCP5 protein network | https://string-db.org/network/9606.ENSP00000480316 | Gamma-tubulin complex component 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome |
| ENSG00000183706 protein network | https://string-db.org/network/9606.ENSP00000480318 | Olfactory receptor; Odorant receptor; Olfactory receptors, family 4 |
| CD99L2 protein network | https://string-db.org/network/9606.ENSP00000480322 | CD99 antigen-like protein 2; Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PE [...] |
| TRAPPC3 protein network | https://string-db.org/network/9606.ENSP00000480332 | Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Trafficking protein particle complex |
| SLC22A24 protein network | https://string-db.org/network/9606.ENSP00000480336 | Solute carrier family 22 member 24 |
| ENSG00000026036 protein network | https://string-db.org/network/9606.ENSP00000480348 | annotation not available |
| CXorf49 protein network | https://string-db.org/network/9606.ENSP00000480355 | Chromosome X open reading frame 49 |
| PDLIM5 protein network | https://string-db.org/network/9606.ENSP00000480359 | PDZ and LIM domain protein 5; May play an important role in the heart development by scaffolding PKC to the Z-disk region. May play a role in the regulation of cardiomyocyte expansion. Overexpres [...] |
| WBSCR16 protein network | https://string-db.org/network/9606.ENSP00000480364 | RCC1-like G exchanging factor-like protein; Williams-Beuren syndrome chromosome region 16 |
| GOLGA6L6 protein network | https://string-db.org/network/9606.ENSP00000480376 | Golgin subfamily A member 6-like protein 6; Golgin A6 family-like 6; Belongs to the GOLGA6 family |
| MTERF4 protein network | https://string-db.org/network/9606.ENSP00000480378 | Transcription termination factor 4, mitochondrial; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA meth [...] |
| ZNF205 protein network | https://string-db.org/network/9606.ENSP00000480401 | Zinc finger protein 205; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| GPR1 protein network | https://string-db.org/network/9606.ENSP00000480405 | G-protein coupled receptor 1; Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Can act as [...] |
| SRRT protein network | https://string-db.org/network/9606.ENSP00000480421 | Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to t [...] |
| B4GALT3 protein network | https://string-db.org/network/9606.ENSP00000480428 | Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Beta 4-glycosy [...] |
| DHRS3 protein network | https://string-db.org/network/9606.ENSP00000480439 | Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH; Short chain dehydrogenase/reductase superfamily |
| HSD11B1L protein network | https://string-db.org/network/9606.ENSP00000480443 | Hydroxysteroid 11-beta-dehydrogenase 1-like protein; Short chain dehydrogenase/reductase superfamily; Belongs to the short-chain dehydrogenases/reductases (SDR) family |
| MSANTD3 protein network | https://string-db.org/network/9606.ENSP00000480445 | Myb/SANT-like DNA-binding domain-containing protein 3; Myb/SANT DNA binding domain containing 3; Belongs to the MSANTD3 family |
| IFNA13 protein network | https://string-db.org/network/9606.ENSP00000480467 | Interferon alpha-1/13; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interf [...] |
| COL19A1 protein network | https://string-db.org/network/9606.ENSP00000480474 | Collagen alpha-1(XIX) chain; May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in or [...] |
| OPLAH protein network | https://string-db.org/network/9606.ENSP00000480476 | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate |
| NRN1 protein network | https://string-db.org/network/9606.ENSP00000480483 | Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells |
| TCHH protein network | https://string-db.org/network/9606.ENSP00000480484 | Trichohyalin; Intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the gran [...] |
| PDZD7 protein network | https://string-db.org/network/9606.ENSP00000480489 | PDZ domain-containing protein 7; Deafness associated genes |
| TSPAN10 protein network | https://string-db.org/network/9606.ENSP00000480492 | Tetraspanin-10; Regulates maturation of the transmembrane metalloprotease ADAM10; Belongs to the tetraspanin (TM4SF) family |
| ITCH protein network | https://string-db.org/network/9606.ENSP00000480499 | E3 ubiquitin-protein ligase Itchy homolog; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly tran [...] |
| TMCO1 protein network | https://string-db.org/network/9606.ENSP00000480514 | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmi [...] |
| GTF2IRD2B protein network | https://string-db.org/network/9606.ENSP00000480524 | General transcription factor II-I repeat domain-containing protein 2B; GTF2I repeat domain containing 2B; Belongs to the TFII-I family |
| ENSG00000256514 protein network | https://string-db.org/network/9606.ENSP00000480527 | annotation not available |
| DNAI1 protein network | https://string-db.org/network/9606.ENSP00000480538 | Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia; Belongs to the dynein intermediate chain family |
| ZNF718 protein network | https://string-db.org/network/9606.ENSP00000480556 | Zinc finger protein 718; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| CCL3L3 protein network | https://string-db.org/network/9606.ENSP00000480558 | C-C motif chemokine 3-like 1; Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fol [...] |
| CYP3A7 protein network | https://string-db.org/network/9606.ENSP00000480571 | Cytochrome P450 3A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a var [...] |
| ADRA2B protein network | https://string-db.org/network/9606.ENSP00000480573 | Alpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agoni [...] |
| OR52E5 protein network | https://string-db.org/network/9606.ENSP00000480583 | Olfactory receptor 52E5; Odorant receptor; Olfactory receptors, family 52 |
| CFAP99 protein network | https://string-db.org/network/9606.ENSP00000480601 | Cilia and flagella associated protein 99 |
| ENSG00000255819 protein network | https://string-db.org/network/9606.ENSP00000480609 | annotation not available |
| ANTXRL protein network | https://string-db.org/network/9606.ENSP00000480615 | Anthrax toxin receptor like |
| ORAI1 protein network | https://string-db.org/network/9606.ENSP00000480616 | Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and cha [...] |
| PRDM11 protein network | https://string-db.org/network/9606.ENSP00000480626 | PR domain-containing protein 11; May be involved in transcription regulation; Belongs to the class V-like SAM-binding methyltransferase superfamily |
| MAGEA6 protein network | https://string-db.org/network/9606.ENSP00000480637 | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and [...] |
| GRIP2 protein network | https://string-db.org/network/9606.ENSP00000480660 | Glutamate receptor-interacting protein 2; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners a [...] |
| SLC46A1 protein network | https://string-db.org/network/9606.ENSP00000480703 | Proton-coupled folate transporter; Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake fr [...] |
| COPZ2 protein network | https://string-db.org/network/9606.ENSP00000480707 | Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosyn [...] |
| IQCE protein network | https://string-db.org/network/9606.ENSP00000480715 | IQ domain-containing protein E; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling |
| NUDT18 protein network | https://string-db.org/network/9606.ENSP00000480722 | 8-oxo-dGDP phosphatase NUDT18; Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside di [...] |
| LRRC39 protein network | https://string-db.org/network/9606.ENSP00000480740 | Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via [...] |
| ZNF385C protein network | https://string-db.org/network/9606.ENSP00000480744 | Zinc finger protein 385C |
| ZAN protein network | https://string-db.org/network/9606.ENSP00000480750 | Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling |
| EPHA5 protein network | https://string-db.org/network/9606.ENSP00000480763 | Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling [...] |
| FGF1 protein network | https://string-db.org/network/9606.ENSP00000480791 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. [...] |
| NDFIP2 protein network | https://string-db.org/network/9606.ENSP00000480798 | NEDD4 family-interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability o [...] |
| LSR protein network | https://string-db.org/network/9606.ENSP00000480821 | Lipolysis-stimulated lipoprotein receptor; Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows [...] |
| PKIB protein network | https://string-db.org/network/9606.ENSP00000480824 | cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme aft [...] |
| HIST1H3A protein network | https://string-db.org/network/9606.ENSP00000480826 | Histone cluster 1 H3 family member a; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| FDFT1 protein network | https://string-db.org/network/9606.ENSP00000480828 | Squalene synthase; Farnesyl-diphosphate farnesyltransferase 1 |
| NOP16 protein network | https://string-db.org/network/9606.ENSP00000480832 | NOP16 nucleolar protein; Belongs to the NOP16 family |
| BCL2L13 protein network | https://string-db.org/network/9606.ENSP00000480836 | Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis; BCL2 family |
| SRRM3 protein network | https://string-db.org/network/9606.ENSP00000480851 | Serine/arginine repetitive matrix 3; Belongs to the CWC21 family |
| VPS29 protein network | https://string-db.org/network/9606.ENSP00000480853 | Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective [...] |
| ST3GAL6 protein network | https://string-db.org/network/9606.ENSP00000480884 | Type 2 lactosamine alpha-2,3-sialyltransferase; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Ga [...] |
| SLC6A6 protein network | https://string-db.org/network/9606.ENSP00000480890 | Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake; Solute carriers |
| SPAST protein network | https://string-db.org/network/9606.ENSP00000480893 | Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with [...] |
| C20orf195 protein network | https://string-db.org/network/9606.ENSP00000480914 | Fibronectin type III domain-containing protein 11; Chromosome 20 open reading frame 195 |
| SLC9A7 protein network | https://string-db.org/network/9606.ENSP00000480916 | Sodium/hydrogen exchanger 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to Golgi volume and cation homeostasis; Solute carriers |
| SETSIP protein network | https://string-db.org/network/9606.ENSP00000480946 | Protein SETSIP; Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cell [...] |
| ZNF280B protein network | https://string-db.org/network/9606.ENSP00000480958 | Zinc finger protein 280B; May function as a transcription factor |
| HIST1H4L protein network | https://string-db.org/network/9606.ENSP00000480960 | Histone cluster 1 H4 family member l; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| P2RY6 protein network | https://string-db.org/network/9606.ENSP00000480966 | P2Y purinoceptor 6; Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; P2Y [...] |
| SSTR3 protein network | https://string-db.org/network/9606.ENSP00000480971 | Somatostatin receptor type 3; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase |
| ZCCHC17 protein network | https://string-db.org/network/9606.ENSP00000480986 | Nucleolar protein of 40 kDa; Zinc finger CCHC-type containing 17 |
| MCM3 protein network | https://string-db.org/network/9606.ENSP00000480987 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiat [...] |
| CHST9 protein network | https://string-db.org/network/9606.ENSP00000480991 | Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynth [...] |
| BHLHE23 protein network | https://string-db.org/network/9606.ENSP00000480998 | Class E basic helix-loop-helix protein 23; May function as transcriptional repressor. May modulate the expression of genes required for the differentiation and/or maintenance of pancreatic and ne [...] |
| PLP1 protein network | https://string-db.org/network/9606.ENSP00000481006 | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; [...] |
| GAS2L1 protein network | https://string-db.org/network/9606.ENSP00000481012 | GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments |
| SHFM1 protein network | https://string-db.org/network/9606.ENSP00000481021 | Putative protein SEM1, isoform 2; Split hand/foot malformation (ectrodactyly) type 1 |
| SCAMP1 protein network | https://string-db.org/network/9606.ENSP00000481022 | Secretory carrier-associated membrane protein 1; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family |
| PSMC3 protein network | https://string-db.org/network/9606.ENSP00000481029 | 26S proteasome regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in [...] |
| CYFIP1 protein network | https://string-db.org/network/9606.ENSP00000481038 | Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit [...] |
| TESK1 protein network | https://string-db.org/network/9606.ENSP00000481045 | Dual specificity testis-specific protein kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and [...] |
| PHOSPHO2 protein network | https://string-db.org/network/9606.ENSP00000481046 | Pyridoxal phosphate phosphatase PHOSPHO2; Phosphatase that has high activity toward pyridoxal 5'- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), [...] |
| RAB44 protein network | https://string-db.org/network/9606.ENSP00000481054 | Ras-related protein Rab-44; RAB44, member RAS oncogene family |
| FCGBP protein network | https://string-db.org/network/9606.ENSP00000481056 | Fc fragment of IgG binding protein |
| GOLGA6L9 protein network | https://string-db.org/network/9606.ENSP00000481078 | Golgin subfamily A member 6-like protein 9; Golgin A6 family-like 9; Belongs to the GOLGA6 family |
| TADA2A protein network | https://string-db.org/network/9606.ENSP00000481091 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domain [...] |
| MGAT4C protein network | https://string-db.org/network/9606.ENSP00000481096 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- [...] |
| E2F8 protein network | https://string-db.org/network/9606.ENSP00000481103 | Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription [...] |
| SGK223 protein network | https://string-db.org/network/9606.ENSP00000481109 | Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth [...] |
| FAM83D protein network | https://string-db.org/network/9606.ENSP00000481110 | Protein FAM83D; Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the [...] |
| FOLR3 protein network | https://string-db.org/network/9606.ENSP00000481114 | Folate receptor gamma; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate |
| VPS11 protein network | https://string-db.org/network/9606.ENSP00000481126 | Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pa [...] |
| PRODH protein network | https://string-db.org/network/9606.ENSP00000481127 | Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate; Belongs to the proline oxidase family |
| ANKRD36B protein network | https://string-db.org/network/9606.ENSP00000481149 | Ankyrin repeat domain-containing protein 36B; Ankyrin repeat domain containing; Belongs to the ANKRD36 family |
| IGHV3-43D protein network | https://string-db.org/network/9606.ENSP00000481152 | V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoprotei [...] |
| CT45A4 protein network | https://string-db.org/network/9606.ENSP00000481184 | Cancer/testis antigen family 45 member A3 |
| GRIFIN protein network | https://string-db.org/network/9606.ENSP00000481185 | Grifin; Galectin-related inter-fiber protein |
| SHISA8 protein network | https://string-db.org/network/9606.ENSP00000481203 | Putative protein shisa-8; Shisa family member 8 |
| FXYD1 protein network | https://string-db.org/network/9606.ENSP00000481244 | Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in [...] |
| SOCS2 protein network | https://string-db.org/network/9606.ENSP00000481249 | Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in [...] |
| TBC1D3I protein network | https://string-db.org/network/9606.ENSP00000481258 | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| SLC38A3 protein network | https://string-db.org/network/9606.ENSP00000481301 | Sodium-coupled neutral amino acid transporter 3; Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recogn [...] |
| SNX12 protein network | https://string-db.org/network/9606.ENSP00000481314 | Sorting nexin-12; May be involved in several stages of intracellular trafficking; Sorting nexins |
| GABRR3 protein network | https://string-db.org/network/9606.ENSP00000481321 | Gamma-aminobutyric acid receptor subunit rho-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor an [...] |
| SAP25 protein network | https://string-db.org/network/9606.ENSP00000481351 | Histone deacetylase complex subunit SAP25; Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex |
| CCL23 protein network | https://string-db.org/network/9606.ENSP00000481357 | C-C motif chemokine ligand 23 |
| TMEM191B protein network | https://string-db.org/network/9606.ENSP00000481358 | Transmembrane protein 191B |
| SLC22A31 protein network | https://string-db.org/network/9606.ENSP00000481421 | Putative solute carrier family 22 member 31; Organic anion transporter that mediates the uptake of ions; Solute carriers |
| AMY2A protein network | https://string-db.org/network/9606.ENSP00000481450 | Pancreatic alpha-amylase; Amylase, alpha 2A |
| TRIM49B protein network | https://string-db.org/network/9606.ENSP00000481457 | Putative tripartite motif-containing protein 49B; Tripartite motif containing 49B; Belongs to the TRIM/RBCC family |
| HIST1H4I protein network | https://string-db.org/network/9606.ENSP00000481486 | Histone cluster 1 H4 family member i; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| DDX24 protein network | https://string-db.org/network/9606.ENSP00000481495 | ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily |
| ENSG00000273136 protein network | https://string-db.org/network/9606.ENSP00000481542 | Neuroblastoma breakpoint family member 1 |
| GRIA3 protein network | https://string-db.org/network/9606.ENSP00000481554 | Glutamate receptor 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate [...] |
| MRM1 protein network | https://string-db.org/network/9606.ENSP00000481559 | rRNA methyltransferase 1, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O- methylguanosine at position 1145 (Gm1145) in the 16S [...] |
| TNFAIP3 protein network | https://string-db.org/network/9606.ENSP00000481570 | Tumor necrosis factor alpha-induced protein 3; Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled b [...] |
| POM121C protein network | https://string-db.org/network/9606.ENSP00000481575 | Nuclear envelope pore membrane protein POM 121C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to [...] |
| FOXD1 protein network | https://string-db.org/network/9606.ENSP00000481581 | Forkhead box protein D1; Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionaliza [...] |
| SMIM22 protein network | https://string-db.org/network/9606.ENSP00000481592 | May modulate lipid droplet formation throught interaction with SQLE |
| HTD2 protein network | https://string-db.org/network/9606.ENSP00000481593 | Hydroxyacyl-thioester dehydratase type 2, mitochondrial; Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis; Belongs to the HTD2 family |
| OR56A5 protein network | https://string-db.org/network/9606.ENSP00000481594 | Olfactory receptor 56A5; Odorant receptor; Olfactory receptors, family 56 |
| POM121L1P protein network | https://string-db.org/network/9606.ENSP00000481613 | annotation not available |
| H2BFS protein network | https://string-db.org/network/9606.ENSP00000481622 | Histone H2B type F-S; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| C18orf25 protein network | https://string-db.org/network/9606.ENSP00000481626 | Uncharacterized protein C18orf25; Chromosome 18 open reading frame 25 |
| RPS10 protein network | https://string-db.org/network/9606.ENSP00000481646 | 40S ribosomal protein S10; Component of the 40S ribosomal subunit; Belongs to the eukaryotic ribosomal protein eS10 family |
| SPRY1 protein network | https://string-db.org/network/9606.ENSP00000481675 | Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis |
| FADS6 protein network | https://string-db.org/network/9606.ENSP00000481684 | Fatty acid desaturase 6; Belongs to the fatty acid desaturase type 1 family |
| SLC35E2B protein network | https://string-db.org/network/9606.ENSP00000481694 | Solute carrier family 35 member E2B; Putative transporter; Solute carriers |
| RSRC1 protein network | https://string-db.org/network/9606.ENSP00000481697 | Serine/Arginine-related protein 53; Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site du [...] |
| SERPINI2 protein network | https://string-db.org/network/9606.ENSP00000481699 | Serpin peptidase inhibitors |
| TBC1D2 protein network | https://string-db.org/network/9606.ENSP00000481721 | TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of ca [...] |
| ABCG4 protein network | https://string-db.org/network/9606.ENSP00000481728 | ATP-binding cassette sub-family G member 4; May be involved in macrophage lipid homeostasis; ATP binding cassette subfamily G |
| FMO1 protein network | https://string-db.org/network/9606.ENSP00000481732 | Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenatio [...] |
| AP5S1 protein network | https://string-db.org/network/9606.ENSP00000481750 | AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862, it is required for efficient homol [...] |
| CSDE1 protein network | https://string-db.org/network/9606.ENSP00000481762 | Cold shock domain-containing protein E1; RNA-binding protein. Required for internal initiation of translation of human rhinovirus RNA. May be involved in translationally coupled mRNA turnover. Im [...] |
| ZNF568 protein network | https://string-db.org/network/9606.ENSP00000481819 | Zinc finger protein 568; Has transcriptional repression activity, partially through the recuitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Es [...] |
| ENSG00000223953 protein network | https://string-db.org/network/9606.ENSP00000481824 | Membrane frizzled-related protein; May play a role in eye development; C1q and TNF related |
| SAP18 protein network | https://string-db.org/network/9606.ENSP00000481842 | Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can [...] |
| KCNN3 protein network | https://string-db.org/network/9606.ENSP00000481848 | Small conductance calcium-activated potassium channel protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolariza [...] |
| JADE3 protein network | https://string-db.org/network/9606.ENSP00000481850 | Protein Jade-3; Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acety [...] |
| FAM13C protein network | https://string-db.org/network/9606.ENSP00000481854 | Protein FAM13C; Family with sequence similarity 13 member C; Belongs to the FAM13 family |
| ARHGAP23 protein network | https://string-db.org/network/9606.ENSP00000481862 | Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state; PDZ domain containing |
| GNB1 protein network | https://string-db.org/network/9606.ENSP00000481878 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling sys [...] |
| CHST12 protein network | https://string-db.org/network/9606.ENSP00000481912 | Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate [...] |
| SEZ6L2 protein network | https://string-db.org/network/9606.ENSP00000481917 | Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons; Belongs to the SEZ6 family |
| MED6 protein network | https://string-db.org/network/9606.ENSP00000481920 | Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Me [...] |
| ZHX1-C8orf76 protein network | https://string-db.org/network/9606.ENSP00000481928 | Zinc fingers and homeoboxes protein 1, isoform 2; ZHX1-C8orf76 readthrough |
| ARHGAP11B protein network | https://string-db.org/network/9606.ENSP00000481934 | Rho GTPase-activating protein 11B; Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the [...] |
| CEACAM20 protein network | https://string-db.org/network/9606.ENSP00000481937 | Carcinoembryonic antigen-related cell adhesion molecule 20; Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a [...] |
| CREB3L1 protein network | https://string-db.org/network/9606.ENSP00000481956 | Cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. In the absence [...] |
| EPHB6 protein network | https://string-db.org/network/9606.ENSP00000481994 | Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negat [...] |
| NR4A3 protein network | https://string-db.org/network/9606.ENSP00000482027 | Nuclear receptor subfamily 4 group A member 3; Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces ge [...] |
| IP6K1 protein network | https://string-db.org/network/9606.ENSP00000482032 | Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4; B [...] |
| PCGF2 protein network | https://string-db.org/network/9606.ENSP00000482063 | Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell prolifer [...] |
| PTGES3 protein network | https://string-db.org/network/9606.ENSP00000482075 | Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localiz [...] |
| PER3 protein network | https://string-db.org/network/9606.ENSP00000482093 | Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processe [...] |
| LOC102724159 protein network | https://string-db.org/network/9606.ENSP00000482107 | annotation not available |
| IQCA1P1 protein network | https://string-db.org/network/9606.ENSP00000482119 | IQ and AAA domain-containing protein 1-like; IQ motif containing with AAA domain 1 pseudogene 1; Belongs to the AAA ATPase family |
| CPEB3 protein network | https://string-db.org/network/9606.ENSP00000482128 | Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimul [...] |
| SYNJ2BP-COX16 protein network | https://string-db.org/network/9606.ENSP00000482133 | SYNJ2BP-COX16 readthrough |
| FAM156A protein network | https://string-db.org/network/9606.ENSP00000482142 | Protein FAM156A/FAM156B; Family with sequence similarity 156 member A |
| NEFL protein network | https://string-db.org/network/9606.ENSP00000482169 | Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber |
| C11orf95 protein network | https://string-db.org/network/9606.ENSP00000482180 | Uncharacterized protein C11orf95; Chromosome 11 open reading frame 95 |
| ZCCHC18 protein network | https://string-db.org/network/9606.ENSP00000482195 | Zinc finger CCHC-type containing 18; Belongs to the ZCCHC12 family |
| PIGW protein network | https://string-db.org/network/9606.ENSP00000482202 | Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol rin [...] |
| BCL2L12 protein network | https://string-db.org/network/9606.ENSP00000482218 | Bcl-2-like protein 12; BCL2 like 12 |
| PLEKHA2 protein network | https://string-db.org/network/9606.ENSP00000482228 | Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins [...] |
| SOCS7 protein network | https://string-db.org/network/9606.ENSP00000482229 | Suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 [...] |
| CGA protein network | https://string-db.org/network/9606.ENSP00000482232 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family |
| ENSG00000273696 protein network | https://string-db.org/network/9606.ENSP00000482241 | annotation not available |
| DACH1 protein network | https://string-db.org/network/9606.ENSP00000482245 | Dachshund homolog 1; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in [...] |
| CCL4 protein network | https://string-db.org/network/9606.ENSP00000482259 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a d [...] |
| ENSG00000277666 protein network | https://string-db.org/network/9606.ENSP00000482263 | annotation not available |
| DGAT1 protein network | https://string-db.org/network/9606.ENSP00000482264 | Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it i [...] |
| CXorf49B protein network | https://string-db.org/network/9606.ENSP00000482270 | Uncharacterized protein CXorf49; Chromosome X open reading frame 49B |
| HIST1H3E protein network | https://string-db.org/network/9606.ENSP00000482271 | Histone cluster 1 H3 family member e; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| C8orf31 protein network | https://string-db.org/network/9606.ENSP00000482282 | Uncharacterized protein C8orf31; Chromosome 8 open reading frame 31 |
| IFFO1 protein network | https://string-db.org/network/9606.ENSP00000482285 | Intermediate filament family orphan 1; Belongs to the intermediate filament family |
| C2orf48 protein network | https://string-db.org/network/9606.ENSP00000482286 | Uncharacterized protein C2orf48; Chromosome 2 open reading frame 48 |
| ZP4 protein network | https://string-db.org/network/9606.ENSP00000482304 | Zona pellucida sperm-binding protein 4; The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy [...] |
| TTC8 protein network | https://string-db.org/network/9606.ENSP00000482306 | Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is requ [...] |
| RECQL4 protein network | https://string-db.org/network/9606.ENSP00000482313 | ATP-dependent DNA helicase Q4; DNA-dependent ATPase. May modulate chromosome segregation; Belongs to the helicase family. RecQ subfamily |
| ANKRD20A3 protein network | https://string-db.org/network/9606.ENSP00000482325 | Ankyrin repeat domain-containing protein 20A3; Ankyrin repeat domain 20 family member A3 |
| MAP7 protein network | https://string-db.org/network/9606.ENSP00000482335 | Ensconsin; Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with micro [...] |
| ENSG00000278299 protein network | https://string-db.org/network/9606.ENSP00000482345 | annotation not available |
| PRSS57 protein network | https://string-db.org/network/9606.ENSP00000482358 | Serine protease 57; Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues; Belongs to the peptidase S1 [...] |
| TMEM99 protein network | https://string-db.org/network/9606.ENSP00000482364 | Transmembrane protein 99 |
| FLJ22184 protein network | https://string-db.org/network/9606.ENSP00000482374 | Proline-rich protein 36; Putative uncharacterized protein FLJ22184 |
| LRP5L protein network | https://string-db.org/network/9606.ENSP00000482378 | Low-density lipoprotein receptor-related protein 5-like protein; LDL receptor related protein 5 like |
| IRX4 protein network | https://string-db.org/network/9606.ENSP00000482393 | Iroquois-class homeodomain protein IRX-4; Likely to be an important mediator of ventricular differentiation during cardiac development; TALE class homeoboxes and pseudogenes |
| ALG9 protein network | https://string-db.org/network/9606.ENSP00000482396 | Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family |
| JRK protein network | https://string-db.org/network/9606.ENSP00000482410 | Jerky protein homolog; May bind DNA; Belongs to the tigger transposable element derived protein family |
| HIST1H2AK protein network | https://string-db.org/network/9606.ENSP00000482431 | Histone cluster 1 H2A family member k; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| DIBD1 protein network | https://string-db.org/network/9606.ENSP00000482437 | Mannosyltransferase; Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; Belongs to the glycosyltransferase 22 family |
| MED22 protein network | https://string-db.org/network/9606.ENSP00000482438 | Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. M [...] |
| FXYD6 protein network | https://string-db.org/network/9606.ENSP00000482442 | FXYD domain containing ion transport regulator 6; Belongs to the FXYD family |
| FAM213A protein network | https://string-db.org/network/9606.ENSP00000482445 | Redox-regulatory protein FAM213A; Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bo [...] |
| PLCG2 protein network | https://string-db.org/network/9606.ENSP00000482457 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by acti [...] |
| LPP protein network | https://string-db.org/network/9606.ENSP00000482472 | Lipoma-preferred partner; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in sign [...] |
| FAM228B protein network | https://string-db.org/network/9606.ENSP00000482482 | HCG1820835, isoform CRA_a; Family with sequence similarity 228 member B |
| RFPL3S protein network | https://string-db.org/network/9606.ENSP00000482492 | Putative protein RFPL3S; RFPL3 antisense |
| TYW1B protein network | https://string-db.org/network/9606.ENSP00000482502 | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found [...] |
| NR2E3 protein network | https://string-db.org/network/9606.ENSP00000482504 | Photoreceptor-specific nuclear receptor; Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. [...] |
| ENSG00000183628 protein network | https://string-db.org/network/9606.ENSP00000482514 | Protein DGCR6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches; Belongs to the gonadal family |
| SPATS2L protein network | https://string-db.org/network/9606.ENSP00000482515 | SPATS2-like protein; Spermatogenesis associated serine rich 2 like; Belongs to the SPATS2 family |
| CDRT4 protein network | https://string-db.org/network/9606.ENSP00000482523 | CMT1A duplicated region transcript 4 |
| HIST1H2AL protein network | https://string-db.org/network/9606.ENSP00000482538 | Histone H2A type 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones [...] |
| ZNF658 protein network | https://string-db.org/network/9606.ENSP00000482540 | Zinc finger protein 658; Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory [...] |
| REC8 protein network | https://string-db.org/network/9606.ENSP00000482546 | Meiotic recombination protein REC8 homolog; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin duri [...] |
| PIP4K2B protein network | https://string-db.org/network/9606.ENSP00000482548 | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate |
| FAM170A protein network | https://string-db.org/network/9606.ENSP00000482552 | Protein FAM170A; Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE) |
| H2AFB3 protein network | https://string-db.org/network/9606.ENSP00000482564 | Histone H2A-Bbd type 2/3; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact [...] |
| AGPAT9 protein network | https://string-db.org/network/9606.ENSP00000482571 | Glycerol-3-phosphate acyltransferase 3; May transfer the acyl-group from acyl-coA to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Also transfers the [...] |
| ZMYM1 protein network | https://string-db.org/network/9606.ENSP00000482579 | Zinc finger MYM-type containing 1 |
| TWIST2 protein network | https://string-db.org/network/9606.ENSP00000482581 | Twist-related protein 2; Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of [...] |
| TBC1D3F protein network | https://string-db.org/network/9606.ENSP00000482590 | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| METTL23 protein network | https://string-db.org/network/9606.ENSP00000482599 | Methyltransferase-like protein 23; Probable methyltransferase |
| GCNT7 protein network | https://string-db.org/network/9606.ENSP00000482600 | Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; Glycosyltransferase; Glucosaminyl transferases/xylosyltransferases |
| HSH2D protein network | https://string-db.org/network/9606.ENSP00000482604 | Hematopoietic SH2 domain-containing protein; May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosi [...] |
| ZNF322 protein network | https://string-db.org/network/9606.ENSP00000482607 | Zinc finger protein 322; Involved in transcriptional regulation as an activator; Belongs to the krueppel C2H2-type zinc-finger protein family |
| PEX12 protein network | https://string-db.org/network/9606.ENSP00000482609 | Peroxisome assembly protein 12; Required for protein import into peroxisomes; Peroxins |
| HMGN3 protein network | https://string-db.org/network/9606.ENSP00000482613 | High mobility group nucleosomal binding domain 3 |
| RAB11FIP4 protein network | https://string-db.org/network/9606.ENSP00000482620 | Rab11 family-interacting protein 4; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'addre [...] |
| TBC1D3H protein network | https://string-db.org/network/9606.ENSP00000482630 | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| ZNF501 protein network | https://string-db.org/network/9606.ENSP00000482632 | Zinc finger protein 501; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| MGST2 protein network | https://string-db.org/network/9606.ENSP00000482639 | Microsomal glutathione S-transferase 2; Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathion [...] |
| MAP3K14 protein network | https://string-db.org/network/9606.ENSP00000482657 | Mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promo [...] |
| HIST1H2BB protein network | https://string-db.org/network/9606.ENSP00000482674 | Histone H2B type 1-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| DHRS11 protein network | https://string-db.org/network/9606.ENSP00000482704 | Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and th [...] |
| ALG1L protein network | https://string-db.org/network/9606.ENSP00000482705 | Putative glycosyltransferase ALG1-like; Putative glycosyltransferase; Glycosyl transferases group 1 domain containing |
| PTPN9 protein network | https://string-db.org/network/9606.ENSP00000482732 | Tyrosine-protein phosphatase non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus; Belongs to the [...] |
| TPSB2 protein network | https://string-db.org/network/9606.ENSP00000482743 | Tryptase beta 2; Belongs to the peptidase S1 family |
| ZNF227 protein network | https://string-db.org/network/9606.ENSP00000482749 | Zinc finger protein 227; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| C9orf72 protein network | https://string-db.org/network/9606.ENSP00000482753 | Guanine nucleotide exchange C9orf72; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 [...] |
| PCSK6 protein network | https://string-db.org/network/9606.ENSP00000482760 | Proprotein convertase subtilisin/kexin type 6; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely fu [...] |
| LARP4B protein network | https://string-db.org/network/9606.ENSP00000482767 | La-related protein 4B; Stimulates mRNA translation; La ribonucleoprotein domain containing |
| FTCDNL1 protein network | https://string-db.org/network/9606.ENSP00000482786 | Formiminotransferase cyclodeaminase N-terminal like |
| MILR1 protein network | https://string-db.org/network/9606.ENSP00000482801 | Allergin-1; Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE- mediated mast cell activation and suppresses the type I immediate [...] |
| ENSG00000160202 protein network | https://string-db.org/network/9606.ENSP00000482816 | Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress co [...] |
| ZNF343 protein network | https://string-db.org/network/9606.ENSP00000482819 | Zinc finger protein 343; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family |
| NAPB protein network | https://string-db.org/network/9606.ENSP00000482826 | Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus |
| SIK1B protein network | https://string-db.org/network/9606.ENSP00000482829 | Probable serine/threonine-protein kinase. |
| AP2B1 protein network | https://string-db.org/network/9606.ENSP00000482835 | AP-2 complex subunit beta; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways [...] |
| CRABP2 protein network | https://string-db.org/network/9606.ENSP00000482841 | Cellular retinoic acid-binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors; Fatty acid binding protein family |
| PTPRQ protein network | https://string-db.org/network/9606.ENSP00000482885 | Phosphatidylinositol phosphatase PTPRQ; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5-bisphosphate (PIP2) level in t [...] |
| PAMR1 protein network | https://string-db.org/network/9606.ENSP00000482899 | Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle; Belongs to the peptidase S1 family |
| PPIP5K2 protein network | https://string-db.org/network/9606.ENSP00000482907 | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphos [...] |
| DOC2B protein network | https://string-db.org/network/9606.ENSP00000482950 | Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE- dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and [...] |
| PRLR protein network | https://string-db.org/network/9606.ENSP00000482954 | Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC [...] |
| FAM65B protein network | https://string-db.org/network/9606.ENSP00000482957 | Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte [...] |
| ALMS1 protein network | https://string-db.org/network/9606.ENSP00000482968 | Alstrom syndrome protein 1; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for p [...] |
| TRIM52 protein network | https://string-db.org/network/9606.ENSP00000483005 | Tripartite motif containing 52; Ring finger proteins |
| ABO protein network | https://string-db.org/network/9606.ENSP00000483018 | Histo-blood group ABO system transferase; This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB indivi [...] |
| SLC2A11 protein network | https://string-db.org/network/9606.ENSP00000483038 | Solute carrier family 2, facilitated glucose transporter member 11; Facilitative glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose [...] |
| ELK1 protein network | https://string-db.org/network/9606.ENSP00000483056 | ETS domain-containing protein Elk-1; Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) [...] |
| NR2C2 protein network | https://string-db.org/network/9606.ENSP00000483059 | Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways suc [...] |
| ZNF74 protein network | https://string-db.org/network/9606.ENSP00000483077 | Zinc finger protein 74; May play a role in RNA metabolism; Belongs to the krueppel C2H2-type zinc-finger protein family |
| ENSG00000278522 protein network | https://string-db.org/network/9606.ENSP00000483103 | Homo sapiens POTE ankyrin domain family, member B-like (LOC102724631), transcript variant 1, mRNA; Belongs to the POTE family |
| TAC3 protein network | https://string-db.org/network/9606.ENSP00000483110 | Tachykinin-3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscle [...] |
| ACD protein network | https://string-db.org/network/9606.ENSP00000483117 | Adrenocortical dysplasia protein homolog; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of d [...] |
| PADI6 protein network | https://string-db.org/network/9606.ENSP00000483125 | Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo |
| ZNF865 protein network | https://string-db.org/network/9606.ENSP00000483134 | Zinc finger protein 865; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| FAM71D protein network | https://string-db.org/network/9606.ENSP00000483154 | Protein FAM71D; Family with sequence similarity 71 member D |
| SMEK2 protein network | https://string-db.org/network/9606.ENSP00000483228 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule org [...] |
| DCAF7 protein network | https://string-db.org/network/9606.ENSP00000483236 | DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The acti [...] |
| HIST1H2BE protein network | https://string-db.org/network/9606.ENSP00000483237 | Histone H2B type 1-C/E/F/G/I; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template [...] |
| OR4M2 protein network | https://string-db.org/network/9606.ENSP00000483239 | Olfactory receptor 4M2; Odorant receptor; Olfactory receptors, family 4 |
| TMEM106A protein network | https://string-db.org/network/9606.ENSP00000483246 | Transmembrane protein 106A; Belongs to the TMEM106 family |
| HNRNPDL protein network | https://string-db.org/network/9606.ENSP00000483254 | Heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity [...] |
| TMEM222 protein network | https://string-db.org/network/9606.ENSP00000483276 | Transmembrane protein 222 |
| MAFIP protein network | https://string-db.org/network/9606.ENSP00000483280 | MaFF-interacting protein; Acts as coactivator of MAFF transcriptional activity. Inhibits cell growth and colony-forming efficiency; Belongs to the tektin family |
| HIST1H3I protein network | https://string-db.org/network/9606.ENSP00000483283 | Histone cluster 1 H3 family member i; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| ACACA protein network | https://string-db.org/network/9606.ENSP00000483300 | Acetyl-CoA carboxylase 1; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and ca [...] |
| WDR38 protein network | https://string-db.org/network/9606.ENSP00000483312 | WD repeat-containing protein 38; WD repeat domain containing |
| WASF2 protein network | https://string-db.org/network/9606.ENSP00000483313 | Wiskott-Aldrich syndrome protein family member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. [...] |
| POLR2J3 protein network | https://string-db.org/network/9606.ENSP00000483328 | DNA-directed RNA polymerase II subunit RPB11-b2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of R [...] |
| SKOR2 protein network | https://string-db.org/network/9606.ENSP00000483333 | SKI family transcriptional corepressor 2; Exhibits transcriptional repressor activity (By similarity). Acts as a TGF-beta antagonist in the nervous system; SKI transcriptional corepressors |
| HDGFRP2 protein network | https://string-db.org/network/9606.ENSP00000483345 | Hepatoma-derived growth factor-related protein 2; Involved in cellular growth control, through the regulation of cyclin D1 expression; Belongs to the HDGF family |
| RIBC2 protein network | https://string-db.org/network/9606.ENSP00000483356 | RIB43A domain with coiled-coils 2 |
| TCTN3 protein network | https://string-db.org/network/9606.ENSP00000483364 | Tectonic-3; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). May be involved in apoptosis regula [...] |
| GALE protein network | https://string-db.org/network/9606.ENSP00000483375 | UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine t [...] |
| RIMBP3 protein network | https://string-db.org/network/9606.ENSP00000483386 | RIMS-binding protein 3A; Component of the manchette, a microtubule-based structure which plays a key role in sperm head morphogenesis during late stages of sperm development. Important for male f [...] |
| GHR protein network | https://string-db.org/network/9606.ENSP00000483403 | Growth hormone receptor; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity); Belongs to [...] |
| RBM26 protein network | https://string-db.org/network/9606.ENSP00000483408 | RNA-binding protein 26; Protein phosphatase 1 regulatory subunits |
| ENSG00000197584 protein network | https://string-db.org/network/9606.ENSP00000483415 | Calcium-activated potassium channel subunit beta-2; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, [...] |
| MARK1 protein network | https://string-db.org/network/9606.ENSP00000483424 | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell [...] |
| IFI27 protein network | https://string-db.org/network/9606.ENSP00000483430 | Interferon alpha-inducible protein 27, mitochondrial; Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and act [...] |
| SYNRG protein network | https://string-db.org/network/9606.ENSP00000483453 | Synergin gamma; May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins |
| SBK3 protein network | https://string-db.org/network/9606.ENSP00000483467 | Uncharacterized serine/threonine-protein kinase SBK3; SH3 domain binding kinase family member 3 |
| GPR179 protein network | https://string-db.org/network/9606.ENSP00000483469 | Probable G-protein coupled receptor 179; Orphan receptor, involved in vision. Required for signal transduction through retinal depolarizing bipolar cells; Belongs to the G-protein coupled recepto [...] |
| NSA2 protein network | https://string-db.org/network/9606.ENSP00000483484 | Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity) |
| ARFRP1 protein network | https://string-db.org/network/9606.ENSP00000483486 | ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipid [...] |
| NTMT1 protein network | https://string-db.org/network/9606.ENSP00000483489 | N-terminal Xaa-Pro-Lys N-methyltransferase 1; Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys wh [...] |
| OXA1L protein network | https://string-db.org/network/9606.ENSP00000483491 | Mitochondrial inner membrane protein OXA1L; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome o [...] |
| R3HCC1L protein network | https://string-db.org/network/9606.ENSP00000483494 | Coiled-coil domain-containing protein R3HCC1L; R3H domain and coiled-coil containing 1 like |
| DDX27 protein network | https://string-db.org/network/9606.ENSP00000483495 | Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 4 [...] |
| HAO2 protein network | https://string-db.org/network/9606.ENSP00000483507 | Hydroxyacid oxidase 2; Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family |
| LEPROT protein network | https://string-db.org/network/9606.ENSP00000483521 | Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor [...] |
| NOL4L protein network | https://string-db.org/network/9606.ENSP00000483523 | Nucleolar protein 4 like |
| C11orf65 protein network | https://string-db.org/network/9606.ENSP00000483537 | Uncharacterized protein C11orf65; Chromosome 11 open reading frame 65 |
| MID1IP1 protein network | https://string-db.org/network/9606.ENSP00000483547 | Mid1-interacting protein 1; Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacy [...] |
| RDM1 protein network | https://string-db.org/network/9606.ENSP00000483549 | RAD52 motif-containing protein 1; May confer resistance to the antitumor agent cisplatin. Binds to DNA and RNA; RNA binding motif containing |
| FURIN protein network | https://string-db.org/network/9606.ENSP00000483552 | Furin; Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif; Proprotein convertase subt [...] |
| SALL2 protein network | https://string-db.org/network/9606.ENSP00000483562 | Sal-like protein 2; Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure; Zinc fingers C2H2-type |
| BTK protein network | https://string-db.org/network/9606.ENSP00000483570 | Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) trigge [...] |
| SPON2 protein network | https://string-db.org/network/9606.ENSP00000483599 | Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage [...] |
| CCL4L1 protein network | https://string-db.org/network/9606.ENSP00000483609 | C-C motif chemokine 4-like; Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5 |
| CABYR protein network | https://string-db.org/network/9606.ENSP00000483621 | Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 [...] |
| CLECL1 protein network | https://string-db.org/network/9606.ENSP00000483624 | C-type lectin-like domain family 1; May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role [...] |
| USP27X protein network | https://string-db.org/network/9606.ENSP00000483631 | Ubiquitin carboxyl-terminal hydrolase 27; Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK- degradation signal. By acting [...] |
| ENSG00000271449 protein network | https://string-db.org/network/9606.ENSP00000483637 | Cancer/testis antigen family 45 member A2 |
| CHD1 protein network | https://string-db.org/network/9606.ENSP00000483667 | Chromodomain-helicase-DNA-binding protein 1; ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) [...] |
| GOLGA6L22 protein network | https://string-db.org/network/9606.ENSP00000483673 | Golgin subfamily A member 6-like protein 22 ; Belongs to the GOLGA6 family |
| PSMB3 protein network | https://string-db.org/network/9606.ENSP00000483688 | Proteasome subunit beta type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles wi [...] |
| KLRF1 protein network | https://string-db.org/network/9606.ENSP00000483713 | Killer cell lectin-like receptor subfamily F member 1; Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts; C-type lectin domain containing |
| ZNF107 protein network | https://string-db.org/network/9606.ENSP00000483720 | Zinc finger protein 107; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ADCYAP1R1 protein network | https://string-db.org/network/9606.ENSP00000483721 | Pituitary adenylate cyclase-activating polypeptide type I receptor; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl c [...] |
| MTUS2 protein network | https://string-db.org/network/9606.ENSP00000483729 | Microtubule-associated tumor suppressor candidate 2; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynam [...] |
| ENSG00000277117 protein network | https://string-db.org/network/9606.ENSP00000483732 | ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and diffe [...] |
| DAOA protein network | https://string-db.org/network/9606.ENSP00000483757 | D-amino acid oxidase activator; Seems to activate D-amino acid oxidase |
| TRIM64 protein network | https://string-db.org/network/9606.ENSP00000483764 | Tripartite motif containing 64; Belongs to the TRIM/RBCC family |
| CISD3 protein network | https://string-db.org/network/9606.ENSP00000483781 | CDGSH iron-sulfur domain-containing protein 3, mitochondrial; CDGSH iron sulfur domain containing; Belongs to the CISD protein family |
| HPCAL1 protein network | https://string-db.org/network/9606.ENSP00000483786 | Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family |
| FXYD4 protein network | https://string-db.org/network/9606.ENSP00000483791 | FXYD domain containing ion transport regulator 4 |
| GAGE13 protein network | https://string-db.org/network/9606.ENSP00000483811 | G antigen 13 |
| NPRL3 protein network | https://string-db.org/network/9606.ENSP00000483814 | GATOR complex protein NPRL3; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrol [...] |
| IKBKG protein network | https://string-db.org/network/9606.ENSP00000483825 | NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and u [...] |
| HIST1H2AB protein network | https://string-db.org/network/9606.ENSP00000483842 | Histone H2A type 1-B/E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Hist [...] |
| TSPAN33 protein network | https://string-db.org/network/9606.ENSP00000483872 | Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficki [...] |
| XKR5 protein network | https://string-db.org/network/9606.ENSP00000483879 | XK-related protein 5; XK related family; Belongs to the XK family |
| LYZL6 protein network | https://string-db.org/network/9606.ENSP00000483897 | Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus [...] |
| HIST1H2BN protein network | https://string-db.org/network/9606.ENSP00000483903 | Histone H2B type 1-N; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histon [...] |
| SSBP2 protein network | https://string-db.org/network/9606.ENSP00000483921 | Single stranded DNA binding protein 2 |
| FAM200B protein network | https://string-db.org/network/9606.ENSP00000483930 | Protein FAM200B; Family with sequence similarity 200 member B; Belongs to the FAM200 family |
| SYTL3 protein network | https://string-db.org/network/9606.ENSP00000483936 | Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity); Synaptotagmin like tande [...] |
| PHF19 protein network | https://string-db.org/network/9606.ENSP00000483946 | PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an acti [...] |
| TBC1D3E protein network | https://string-db.org/network/9606.ENSP00000483965 | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| TCEB3CL2 protein network | https://string-db.org/network/9606.ENSP00000483981 | Elongin-A3 member D; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. [...] |
| CD24 protein network | https://string-db.org/network/9606.ENSP00000483985 | Signal transducer CD24; May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and [...] |
| ENSG00000260300 protein network | https://string-db.org/network/9606.ENSP00000484042 | Uncharacterized protein |
| ZCCHC3 protein network | https://string-db.org/network/9606.ENSP00000484056 | Zinc finger CCHC-type containing 3 |
| PACSIN1 protein network | https://string-db.org/network/9606.ENSP00000484060 | Protein kinase C and casein kinase substrate in neurons protein 1; Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule sta [...] |
| CCL15 protein network | https://string-db.org/network/9606.ENSP00000484078 | C-C motif chemokine 15; Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15 [...] |
| HIST1H3F protein network | https://string-db.org/network/9606.ENSP00000484095 | Histone cluster 1 H3 family member f; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| PRIM2 protein network | https://string-db.org/network/9606.ENSP00000484105 | DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication |
| ARFIP2 protein network | https://string-db.org/network/9606.ENSP00000484121 | Arfaptin-2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling; Classical BAR domain containing |
| COLCA2 protein network | https://string-db.org/network/9606.ENSP00000484135 | Colorectal cancer associated 2 |
| ENSG00000273637 protein network | https://string-db.org/network/9606.ENSP00000484144 | annotation not available |
| SEMA3B protein network | https://string-db.org/network/9606.ENSP00000484146 | Semaphorin-3B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Belongs to the semaphorin family |
| CLEC18A protein network | https://string-db.org/network/9606.ENSP00000484176 | C-type lectin domain family 18 member A; Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans; C-type lectin domain containin [...] |
| TBC1D3K protein network | https://string-db.org/network/9606.ENSP00000484181 | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| ATRAID protein network | https://string-db.org/network/9606.ENSP00000484228 | All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 e [...] |
| PRAMEF7 protein network | https://string-db.org/network/9606.ENSP00000484237 | PRAME family member 7; Belongs to the PRAME family |
| TSGA10IP protein network | https://string-db.org/network/9606.ENSP00000484252 | Testis specific 10 interacting protein |
| H2AFB1 protein network | https://string-db.org/network/9606.ENSP00000484261 | Histone H2A-Bbd type 1; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact D [...] |
| TMEM114 protein network | https://string-db.org/network/9606.ENSP00000484263 | Transmembrane protein 114 |
| LIG4 protein network | https://string-db.org/network/9606.ENSP00000484288 | DNA ligase 4; Efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double- [...] |
| MREG protein network | https://string-db.org/network/9606.ENSP00000484331 | Melanoregulin; Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity) |
| NEB protein network | https://string-db.org/network/9606.ENSP00000484342 | Nebulin |
| SERPINB6 protein network | https://string-db.org/network/9606.ENSP00000484343 | Serpin B6; May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May pl [...] |
| SMTN protein network | https://string-db.org/network/9606.ENSP00000484398 | Smoothelin; Structural protein of the cytoskeleton; Belongs to the smoothelin family |
| TPTE protein network | https://string-db.org/network/9606.ENSP00000484403 | Putative tyrosine-protein phosphatase TPTE; Could be involved in signal transduction; C2 tensin-type domain containing |
| HOXA3 protein network | https://string-db.org/network/9606.ENSP00000484411 | Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterio [...] |
| NT5C3A protein network | https://string-db.org/network/9606.ENSP00000484415 | Cytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrat [...] |
| CD48 protein network | https://string-db.org/network/9606.ENSP00000484431 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation |
| NEK3 protein network | https://string-db.org/network/9606.ENSP00000484443 | Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contribute [...] |
| EPPK1 protein network | https://string-db.org/network/9606.ENSP00000484472 | Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is ass [...] |
| IFNA5 protein network | https://string-db.org/network/9606.ENSP00000484479 | Interferon alpha-5; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase; Interfero [...] |
| C8orf59 protein network | https://string-db.org/network/9606.ENSP00000484492 | Uncharacterized protein C8orf59; Chromosome 8 open reading frame 59 |
| OVCH2 protein network | https://string-db.org/network/9606.ENSP00000484497 | Ovochymase-2; Ovochymase 2 |
| CTDP1 protein network | https://string-db.org/network/9606.ENSP00000484525 | RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase I [...] |
| MIS12 protein network | https://string-db.org/network/9606.ENSP00000484532 | Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore m [...] |
| ENSG00000275217 protein network | https://string-db.org/network/9606.ENSP00000484537 | annotation not available |
| GJA5 protein network | https://string-db.org/network/9606.ENSP00000484552 | Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a [...] |
| TBC1D3B protein network | https://string-db.org/network/9606.ENSP00000484556 | TBC1 domain family member 3B; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) |
| PPP1R2 protein network | https://string-db.org/network/9606.ENSP00000484580 | Protein phosphatase inhibitor 2; Inhibitor of protein-phosphatase 1 |
| GLYAT protein network | https://string-db.org/network/9606.ENSP00000484592 | Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrate [...] |
| CT45A10 protein network | https://string-db.org/network/9606.ENSP00000484601 | Cancer/testis antigen family 45 member A5 |
| OBP2B protein network | https://string-db.org/network/9606.ENSP00000484615 | Odorant-binding protein 2b; Probably binds and transports small hydrophobic volatile molecules; Belongs to the calycin superfamily. Lipocalin family |
| APELA protein network | https://string-db.org/network/9606.ENSP00000484618 | Apelin receptor early endogenous ligand; Hormone required for endoderm differentiation and heart morphogenesis during early development and for the adult cardiovascular system development by acti [...] |
| PMP22 protein network | https://string-db.org/network/9606.ENSP00000484631 | Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family |
| LRRC6 protein network | https://string-db.org/network/9606.ENSP00000484634 | Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility |
| HIST1H3G protein network | https://string-db.org/network/9606.ENSP00000484638 | Histone cluster 1 H3 family member g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| B3GNT6 protein network | https://string-db.org/network/9606.ENSP00000484640 | Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that synthesizes the core 3 structure of the O-glycan, an important [...] |
| NXF2B protein network | https://string-db.org/network/9606.ENSP00000484645 | Nuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm |
| MDFIC protein network | https://string-db.org/network/9606.ENSP00000484656 | MyoD family inhibitor domain-containing protein; Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nucl [...] |
| HIST1H3C protein network | https://string-db.org/network/9606.ENSP00000484658 | Histone cluster 1 H3 family member c; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a [...] |
| GAGE1 protein network | https://string-db.org/network/9606.ENSP00000484668 | G antigen 1; Belongs to the GAGE family |
| CPSF1 protein network | https://string-db.org/network/9606.ENSP00000484669 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, rec [...] |
| ZNHIT3 protein network | https://string-db.org/network/9606.ENSP00000484687 | Zinc finger HIT-type containing 3 |
| IFITM2 protein network | https://string-db.org/network/9606.ENSP00000484689 | Interferon-induced transmembrane protein 2; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral f [...] |
| C17orf96 protein network | https://string-db.org/network/9606.ENSP00000484710 | Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine- tune the transcriptional status of Polycomb group (PcG) target g [...] |
| KIAA1033 protein network | https://string-db.org/network/9606.ENSP00000484713 | WASH complex subunit 4; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in [...] |
| SRCIN1 protein network | https://string-db.org/network/9606.ENSP00000484715 | SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Reg [...] |
| GATSL2 protein network | https://string-db.org/network/9606.ENSP00000484732 | Cytosolic arginine sensor for mTORC1 subunit 2; Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, dir [...] |
| HIST1H4E protein network | https://string-db.org/network/9606.ENSP00000484789 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby [...] |
| FOXP1 protein network | https://string-db.org/network/9606.ENSP00000484803 | Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specifi [...] |
| ARMC9 protein network | https://string-db.org/network/9606.ENSP00000484804 | LisH domain-containing protein ARMC9; Armadillo repeat containing 9 |
| SPATA31A7 protein network | https://string-db.org/network/9606.ENSP00000484807 | Spermatogenesis-associated protein 31A7; May play a role in spermatogenesis |
| MUC1 protein network | https://string-db.org/network/9606.ENSP00000484824 | Mucin-1; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme [...] |
| HIST1H3B protein network | https://string-db.org/network/9606.ENSP00000484841 | Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones there [...] |
| ZNF283 protein network | https://string-db.org/network/9606.ENSP00000484852 | Zinc finger protein 283; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| EXOC5 protein network | https://string-db.org/network/9606.ENSP00000484855 | Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane |
| ADAM29 protein network | https://string-db.org/network/9606.ENSP00000484862 | Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein; ADAM metallopeptida [...] |
| FOXD4L6 protein network | https://string-db.org/network/9606.ENSP00000484875 | Forkhead box D4 like 6 |
| C10orf126 protein network | https://string-db.org/network/9606.ENSP00000484883 | Putative uncharacterized protein C10orf126; Chromosome 10 open reading frame 126 |
| NUTM2D protein network | https://string-db.org/network/9606.ENSP00000484887 | NUT family member 2D; Belongs to the NUT family |
| PIGBOS1 protein network | https://string-db.org/network/9606.ENSP00000484893 | Protein PIGBOS1; PIGB opposite strand 1 |
| MRPL45 protein network | https://string-db.org/network/9606.ENSP00000484903 | Mitochondrial ribosomal protein L45 |
| CAPS protein network | https://string-db.org/network/9606.ENSP00000484912 | Calcyphosin; Calcium-binding protein. May play a role in cellular signaling events (Potential); EF-hand domain containing |
| CDH4 protein network | https://string-db.org/network/9606.ENSP00000484928 | Cadherin-4; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the s [...] |
| ZSCAN26 protein network | https://string-db.org/network/9606.ENSP00000484931 | Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing |
| PRAC2 protein network | https://string-db.org/network/9606.ENSP00000484945 | PRAC2 small nuclear protein |
| CIITA protein network | https://string-db.org/network/9606.ENSP00000485010 | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected [...] |
| ENSG00000160201 protein network | https://string-db.org/network/9606.ENSP00000485022 | Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required fo [...] |
| MUC13 protein network | https://string-db.org/network/9606.ENSP00000485028 | Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling; Mucins |
| DEFB133 protein network | https://string-db.org/network/9606.ENSP00000485031 | Beta-defensin 133; Has antibacterial activity; Defensins, beta |
| OR10C1 protein network | https://string-db.org/network/9606.ENSP00000485032 | Olfactory receptor 10C1; Odorant receptor; Olfactory receptors, family 10 |
| ENSG00000279508 protein network | https://string-db.org/network/9606.ENSP00000485043 | annotation not available |
| ENSG00000280178 protein network | https://string-db.org/network/9606.ENSP00000485053 | PP13850 |
| SLC27A3 protein network | https://string-db.org/network/9606.ENSP00000485061 | Long-chain fatty acid transport protein 3; Has acyl-CoA ligase activity for long-chain and very- long-chain fatty acids. Does not exhibit fatty acid transport activity (By similarity); Acyl-CoA s [...] |
| OR2S2 protein network | https://string-db.org/network/9606.ENSP00000485066 | Olfactory receptor 2S2; Odorant receptor; Olfactory receptors, family 2 |
| ERVK-10 protein network | https://string-db.org/network/9606.ENSP00000485075 | May possess a function in tumorigenesis |
| OR52B4 protein network | https://string-db.org/network/9606.ENSP00000485078 | Olfactory receptor 52B4; Odorant receptor; Olfactory receptors, family 52 |
| TRIM49D2P protein network | https://string-db.org/network/9606.ENSP00000485097 | Tripartite motif containing 49D2, pseudogene; Belongs to the TRIM/RBCC family |
| PKD1L2 protein network | https://string-db.org/network/9606.ENSP00000485105 | Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor; C-type lectin domain containing |
| UBTFL1 protein network | https://string-db.org/network/9606.ENSP00000485108 | Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development |
| ENSG00000279342 protein network | https://string-db.org/network/9606.ENSP00000485115 | annotation not available |
| SPATA31A3 protein network | https://string-db.org/network/9606.ENSP00000485118 | Spermatogenesis-associated protein 31A3; May play a role in spermatogenesis |
| KCNE1B protein network | https://string-db.org/network/9606.ENSP00000485125 | annotation not available |
| ENSG00000279392 protein network | https://string-db.org/network/9606.ENSP00000485133 | Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because [...] |
| ENSG00000279058 protein network | https://string-db.org/network/9606.ENSP00000485140 | annotation not available |
| DEFB131B protein network | https://string-db.org/network/9606.ENSP00000485141 | Has antibacterial activity |
| ENSG00000280108 protein network | https://string-db.org/network/9606.ENSP00000485142 | annotation not available |
| OR11H2 protein network | https://string-db.org/network/9606.ENSP00000485150 | Olfactory receptor 11H2; Odorant receptor; Olfactory receptors, family 11 |
| ENSG00000279890 protein network | https://string-db.org/network/9606.ENSP00000485172 | May function as an ion-channel regulator. May function as a G-protein-coupled receptor |
| BAGE5 protein network | https://string-db.org/network/9606.ENSP00000485185 | Unknown. Candidate gene encoding tumor antigens |
| OR4X2 protein network | https://string-db.org/network/9606.ENSP00000485191 | Olfactory receptor 4X2; Odorant receptor; Olfactory receptors, family 4 |
| ZNF735P protein network | https://string-db.org/network/9606.ENSP00000485193 | May be involved in transcriptional regulation |
| ENSG00000279316 protein network | https://string-db.org/network/9606.ENSP00000485194 | Chromosome 15 open reading frame 32 |
| PPIAL4B protein network | https://string-db.org/network/9606.ENSP00000485206 | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) |
| OR8B4 protein network | https://string-db.org/network/9606.ENSP00000485212 | Olfactory receptor 8B4; Odorant receptor; Olfactory receptors, family 8 |
| LINC00116 protein network | https://string-db.org/network/9606.ENSP00000485216 | Uncharacterized protein encoded by LINC00116; Long intergenic non-protein coding RNA 116 |
| ERVK-24 protein network | https://string-db.org/network/9606.ENSP00000485226 | May possess a function in tumorigenesis |
| SPDYE6 protein network | https://string-db.org/network/9606.ENSP00000485230 | speedy/RINGO cell cycle regulator family member E6 |
| USP17L4 protein network | https://string-db.org/network/9606.ENSP00000485243 | Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 4; Ubiquitin specific peptidase 17-like family member 4 |
| PRAMEF25 protein network | https://string-db.org/network/9606.ENSP00000485258 | PRAME family member 25 |
| ENSG00000278882 protein network | https://string-db.org/network/9606.ENSP00000485259 | annotation not available |
| ENSG00000164096 protein network | https://string-db.org/network/9606.ENSP00000485260 | Chromosome 4 open reading frame 3 |
| ENSG00000279533 protein network | https://string-db.org/network/9606.ENSP00000485261 | annotation not available |
| ENSG00000279168 protein network | https://string-db.org/network/9606.ENSP00000485271 | annotation not available |
| USP17L8 protein network | https://string-db.org/network/9606.ENSP00000485306 | Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 8; Ubiquitin specific peptidase 17-like family member 8 |
| LINC00493 protein network | https://string-db.org/network/9606.ENSP00000485316 | Small integral membrane protein 26; Long intergenic non-protein coding RNA 493 |
| USP17L3 protein network | https://string-db.org/network/9606.ENSP00000485323 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 3; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...] |
| OR2AG1 protein network | https://string-db.org/network/9606.ENSP00000485326 | Olfactory receptor 2AG1; Odorant receptor; Olfactory receptors, family 2 |
| USP17L7 protein network | https://string-db.org/network/9606.ENSP00000485337 | Inactive ubiquitin carboxyl-terminal hydrolase 17-like protein 7; Ubiquitin specific peptidase 17-like family member 7 |
| ENSG00000280297 protein network | https://string-db.org/network/9606.ENSP00000485342 | annotation not available |
| HMCN2 protein network | https://string-db.org/network/9606.ENSP00000485357 | Hemicentin-2; Immunoglobulin like domain containing; Fibulins |
| USP17L1P protein network | https://string-db.org/network/9606.ENSP00000485364 | Ubiquitin carboxyl-terminal hydrolase 17-like protein 1; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include [...] |
| ENSG00000279132 protein network | https://string-db.org/network/9606.ENSP00000485366 | Protein FAM231A; Family with sequence similarity 231, member A; Belongs to the FAM231 family |
| FAM25HP protein network | https://string-db.org/network/9606.ENSP00000485370 | Protein FAM25A; Family with sequence similarity 25, member H pseudogene; Belongs to the FAM25 family |
| TRIM39-RPP21 protein network | https://string-db.org/network/9606.ENSP00000485378 | Ribonuclease P protein subunit p21; TRIM39-RPP21 readthrough |
| ENSG00000279576 protein network | https://string-db.org/network/9606.ENSP00000485396 | Metastasis-associated lung adenocarcinoma transcript 1 |
| SPDYE5 protein network | https://string-db.org/network/9606.ENSP00000485398 | speedy/RINGO cell cycle regulator family member E5 |
| C11orf44 protein network | https://string-db.org/network/9606.ENSP00000485399 | Uncharacterized protein C11orf44; Chromosome 11 open reading frame 44 |
| UQCRHL protein network | https://string-db.org/network/9606.ENSP00000485401 | May be a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formati [...] |
| OR5AR1 protein network | https://string-db.org/network/9606.ENSP00000485424 | Olfactory receptor 5AR1; Odorant receptor; Olfactory receptors, family 5 |
| WASH2P protein network | https://string-db.org/network/9606.ENSP00000485442 | Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules [...] |
| PRSS3P2 protein network | https://string-db.org/network/9606.ENSP00000485444 | Trypsin-2; In the ileum, may be involved in defensin processing, including DEFA5; Belongs to the peptidase S1 family |
| ZNF727P protein network | https://string-db.org/network/9606.ENSP00000485448 | Putative zinc finger protein 727; May be involved in transcriptional regulation |
| HNRNPCL2 protein network | https://string-db.org/network/9606.ENSP00000485450 | Heterogeneous nuclear ribonucleoprotein C-like 3; May play a role in nucleosome assembly by neutralizing basic proteins such as A and B core hnRNPs |
| DUX4L8 protein network | https://string-db.org/network/9606.ENSP00000485452 | Double homeodomain protein DUX4-s; PRD class homeoboxes and pseudogenes |
| ENSG00000279928 protein network | https://string-db.org/network/9606.ENSP00000485457 | annotation not available |
| ENSG00000205457 protein network | https://string-db.org/network/9606.ENSP00000485467 | TP53 target 3C; May play a significant role in p53/TP53-mediating signaling pathway |
| PRAMEF18 protein network | https://string-db.org/network/9606.ENSP00000485473 | PRAME family member 18; Belongs to the PRAME family |
| CDHR1 protein network | https://string-db.org/network/9606.ENSP00000485478 | Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity); [...] |
| FER1L5 protein network | https://string-db.org/network/9606.ENSP00000485487 | Fer-1-like protein 5; Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation; Belongs to the ferlin family |
| C5orf64 protein network | https://string-db.org/network/9606.ENSP00000485493 | Uncharacterized protein C5orf64; Chromosome 5 open reading frame 64 |
| QRFP protein network | https://string-db.org/network/9606.ENSP00000485512 | Orexigenic neuropeptide QRFP; Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by t [...] |
| DCHS2 protein network | https://string-db.org/network/9606.ENSP00000485514 | Protocadherin-23; Calcium-dependent cell-adhesion protein; Cadherin related |
| ENSG00000279515 protein network | https://string-db.org/network/9606.ENSP00000485520 | HCG1732469; Putative uncharacterized protein FLJ20019 |
| ADSL protein network | https://string-db.org/network/9606.ENSP00000485525 | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5- [...] |
| RASSF10 protein network | https://string-db.org/network/9606.ENSP00000485526 | Ras association domain family member 10 |
| ENSG00000279906 protein network | https://string-db.org/network/9606.ENSP00000485529 | annotation not available |
| OR2F1 protein network | https://string-db.org/network/9606.ENSP00000485535 | Olfactory receptor 2F1; Odorant receptor; Olfactory receptors, family 2 |
| MAGEA2 protein network | https://string-db.org/network/9606.ENSP00000485541 | Melanoma-associated antigen 2; Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiqui [...] |
| SAA2-SAA4 protein network | https://string-db.org/network/9606.ENSP00000485552 | SAA2-SAA4 readthrough |
| ENSG00000229117 protein network | https://string-db.org/network/9606.ENSP00000485567 | 60S ribosomal protein L41; Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII; L ribosomal proteins |
| CERS1 protein network | https://string-db.org/network/9606.ENSP00000485582 | annotation not available |
| SLC35G4P protein network | https://string-db.org/network/9606.ENSP00000485584 | Solute carrier family 35, member G4, pseudogene |
| NXF2 protein network | https://string-db.org/network/9606.ENSP00000485586 | Nuclear RNA export factor 2; Involved in the export of mRNA from the nucleus to the cytoplasm; Belongs to the NXF family |
| ENSG00000261832 protein network | https://string-db.org/network/9606.ENSP00000485589 | Battenin isoform d |
| ENSG00000198590 protein network | https://string-db.org/network/9606.ENSP00000485610 | Chromosome 3 open reading frame 35 |
| ZNF518A protein network | https://string-db.org/network/9606.ENSP00000485614 | Zinc finger protein 518A; May be involved in transcriptional regulation; Zinc fingers C2H2-type |
| ENSG00000280433 protein network | https://string-db.org/network/9606.ENSP00000485615 | TMEM1 protein |
| WASH1 protein network | https://string-db.org/network/9606.ENSP00000485627 | WASH complex subunit 1; Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key r [...] |
| GVQW2 protein network | https://string-db.org/network/9606.ENSP00000485629 | Uncharacterized protein LOC100507462 |
| ENSG00000276612 protein network | https://string-db.org/network/9606.ENSP00000485630 | annotation not available |
| ENSG00000278848 protein network | https://string-db.org/network/9606.ENSP00000485635 | annotation not available |
| ENSG00000279782 protein network | https://string-db.org/network/9606.ENSP00000485638 | annotation not available |
| ENSG00000280267 protein network | https://string-db.org/network/9606.ENSP00000485656 | annotation not available |
| MUC5AC protein network | https://string-db.org/network/9606.ENSP00000485659 | Mucin-5AC; Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that ar [...] |
| EIF3L protein network | https://string-db.org/network/9606.ENSP00000485663 | Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein [...] |
| ENSG00000279493 protein network | https://string-db.org/network/9606.ENSP00000485664 | annotation not available |
| LINC02203 protein network | https://string-db.org/network/9606.ENSP00000485668 | annotation not available |
| OR6Q1 protein network | https://string-db.org/network/9606.ENSP00000485678 | Olfactory receptor 6Q1; Odorant receptor; Olfactory receptors, family 6 |